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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GUAACAG

Z-value: 1.81

Motif logo

logo of

miRNA associated with seed GUAACAG

NamemiRBASE accession
hsa-miR-194-5p
MIMAT0000460

Activity profile of GUAACAG motif

Sorted Z-values of GUAACAG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GUAACAG

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_149971109 6.43 ENST00000239940.11
PFN2
profilin 2
chr17_-_64662290 5.85 ENST00000262435.14
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr20_-_45348414 5.22 ENST00000372733.3
SDC4
syndecan 4
chr1_-_225653045 4.81 ENST00000366843.6
ENST00000366844.7
ENAH
ENAH actin regulator
chrX_+_120604084 4.15 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr14_+_61695777 4.07 ENST00000323441.10
HIF1A
hypoxia inducible factor 1 subunit alpha
chr11_-_115504389 3.91 ENST00000545380.5
ENST00000452722.7
ENST00000331581.11
ENST00000537058.5
ENST00000536727.5
ENST00000542447.6
CADM1
cell adhesion molecule 1
chr9_+_128683645 3.77 ENST00000372692.8
SET
SET nuclear proto-oncogene
chr11_+_74949241 3.76 ENST00000610881.4
ENST00000530257.5
ENST00000526361.1
ENST00000532972.5
ENST00000263672.11
SPCS2
signal peptidase complex subunit 2
chr17_-_59707404 3.76 ENST00000393038.3
PTRH2
peptidyl-tRNA hydrolase 2
chr3_+_62319037 3.60 ENST00000494481.5
C3orf14
chromosome 3 open reading frame 14
chr12_-_29381141 3.44 ENST00000546839.5
ENST00000552155.5
ENST00000360150.9
ENST00000550353.5
ENST00000548441.1
ENST00000552132.5
ERGIC2
ERGIC and golgi 2
chr8_+_48008409 3.29 ENST00000523432.5
ENST00000521346.5
ENST00000523111.7
ENST00000517630.5
UBE2V2
ubiquitin conjugating enzyme E2 V2
chr12_+_123584523 3.25 ENST00000438031.2
ENST00000262225.8
TMED2
transmembrane p24 trafficking protein 2
chr16_-_58734299 3.23 ENST00000245206.10
ENST00000434819.2
GOT2
glutamic-oxaloacetic transaminase 2
chr1_-_202808406 3.15 ENST00000650569.1
ENST00000367265.9
ENST00000649770.1
KDM5B
lysine demethylase 5B
chr1_-_205750167 3.13 ENST00000367142.5
NUCKS1
nuclear casein kinase and cyclin dependent kinase substrate 1
chr5_+_72816643 3.11 ENST00000337273.10
ENST00000523768.5
TNPO1
transportin 1
chr2_-_229921963 3.06 ENST00000343290.5
ENST00000389044.8
ENST00000675453.1
ENST00000675903.1
ENST00000283943.9
TRIP12
thyroid hormone receptor interactor 12
chr3_-_72446623 3.01 ENST00000477973.4
RYBP
RING1 and YY1 binding protein
chr5_+_177592182 2.92 ENST00000332598.7
TMED9
transmembrane p24 trafficking protein 9
chr19_+_34428353 2.63 ENST00000590048.6
ENST00000246548.9
UBA2
ubiquitin like modifier activating enzyme 2
chr18_+_9913979 2.61 ENST00000400000.7
ENST00000340541.4
VAPA
VAMP associated protein A
chr1_-_11060000 2.54 ENST00000376957.7
SRM
spermidine synthase
chr2_+_84971093 2.50 ENST00000456682.1
ENST00000409785.9
KCMF1
potassium channel modulatory factor 1
chr3_-_113746218 2.42 ENST00000497255.1
ENST00000240922.8
ENST00000478020.1
ENST00000493900.5
NAA50
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr1_+_26921715 2.39 ENST00000321265.10
NUDC
nuclear distribution C, dynein complex regulator
chr3_+_180912656 2.38 ENST00000357559.9
ENST00000491062.5
ENST00000468861.5
ENST00000445140.6
ENST00000484958.5
FXR1
FMR1 autosomal homolog 1
chr1_+_51236252 2.27 ENST00000242719.4
RNF11
ring finger protein 11
chr2_-_173965356 2.21 ENST00000310015.12
SP3
Sp3 transcription factor
chr7_+_77537258 2.19 ENST00000248594.11
PTPN12
protein tyrosine phosphatase non-receptor type 12
chr17_+_68512379 2.12 ENST00000392711.5
ENST00000585427.5
ENST00000589228.6
ENST00000536854.6
ENST00000588702.5
ENST00000589309.5
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr8_-_130443581 2.03 ENST00000357668.2
ENST00000518721.6
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr3_-_57597325 1.99 ENST00000496292.5
ENST00000489843.1
ENST00000303436.11
ARF4
ADP ribosylation factor 4
chr1_+_93345893 1.94 ENST00000370272.9
ENST00000370267.1
DR1
down-regulator of transcription 1
chr15_-_37098281 1.93 ENST00000559085.5
ENST00000397624.7
MEIS2
Meis homeobox 2
chr21_-_15064934 1.89 ENST00000400199.5
ENST00000400202.5
ENST00000318948.7
NRIP1
nuclear receptor interacting protein 1
chr11_+_102110437 1.83 ENST00000282441.10
ENST00000526343.5
ENST00000537274.5
ENST00000345877.6
ENST00000615667.4
YAP1
Yes1 associated transcriptional regulator
chr9_-_72364504 1.81 ENST00000237937.7
ENST00000343431.6
ENST00000376956.3
ZFAND5
zinc finger AN1-type containing 5
chr12_-_76031588 1.65 ENST00000602540.5
PHLDA1
pleckstrin homology like domain family A member 1
chr3_-_58433810 1.59 ENST00000474765.1
ENST00000485460.5
ENST00000302746.11
ENST00000383714.8
PDHB
pyruvate dehydrogenase E1 subunit beta
chr1_-_51990679 1.54 ENST00000371655.4
RAB3B
RAB3B, member RAS oncogene family
chr15_+_96330691 1.47 ENST00000394166.8
NR2F2
nuclear receptor subfamily 2 group F member 2
chr5_-_140346596 1.47 ENST00000230990.7
HBEGF
heparin binding EGF like growth factor
chr3_+_9397602 1.44 ENST00000402198.7
SETD5
SET domain containing 5
chr14_-_54489003 1.43 ENST00000554908.5
ENST00000616146.4
GMFB
glia maturation factor beta
chr2_-_157874976 1.42 ENST00000682025.1
ENST00000683487.1
ENST00000682300.1
ENST00000683441.1
ENST00000684595.1
ENST00000683426.1
ENST00000683820.1
ENST00000263640.7
ACVR1
activin A receptor type 1
chr17_+_2593628 1.39 ENST00000397195.10
PAFAH1B1
platelet activating factor acetylhydrolase 1b regulatory subunit 1
chr18_-_28177102 1.39 ENST00000413878.2
ENST00000269141.8
CDH2
cadherin 2
chr10_-_33334625 1.37 ENST00000374875.5
ENST00000374822.8
ENST00000374867.7
NRP1
neuropilin 1
chr10_+_103967105 1.37 ENST00000369755.4
ENST00000335753.8
SLK
STE20 like kinase
chr22_-_30246739 1.32 ENST00000403987.3
ENST00000249075.4
LIF
LIF interleukin 6 family cytokine
chr7_-_88220025 1.29 ENST00000419179.5
ENST00000265729.7
SRI
sorcin
chr4_+_39698109 1.28 ENST00000510934.5
ENST00000261427.10
UBE2K
ubiquitin conjugating enzyme E2 K
chr4_-_24584517 1.25 ENST00000336812.5
DHX15
DEAH-box helicase 15
chr6_+_20401864 1.22 ENST00000346618.8
ENST00000613242.4
E2F3
E2F transcription factor 3
chr1_-_211579064 1.20 ENST00000367001.5
SLC30A1
solute carrier family 30 member 1
chr15_-_58933668 1.16 ENST00000380516.7
SLTM
SAFB like transcription modulator
chr16_-_11915878 1.15 ENST00000439887.6
ENST00000434724.7
GSPT1
G1 to S phase transition 1
chr4_+_127782270 1.15 ENST00000508549.5
ENST00000296464.9
HSPA4L
heat shock protein family A (Hsp70) member 4 like
chr3_+_153162196 1.11 ENST00000323534.5
RAP2B
RAP2B, member of RAS oncogene family
chr17_-_75182949 1.10 ENST00000314523.7
ENST00000420826.7
SUMO2
small ubiquitin like modifier 2
chr1_-_153986329 1.10 ENST00000368575.5
RAB13
RAB13, member RAS oncogene family
chr15_+_39581068 1.06 ENST00000397591.2
ENST00000260356.6
THBS1
thrombospondin 1
chr3_+_150408314 1.02 ENST00000361875.7
TSC22D2
TSC22 domain family member 2
chr15_-_59689283 1.00 ENST00000607373.6
ENST00000612191.4
ENST00000267859.8
BNIP2
BCL2 interacting protein 2
chr12_-_26125023 0.98 ENST00000242728.5
BHLHE41
basic helix-loop-helix family member e41
chr10_-_86521737 0.91 ENST00000298767.10
WAPL
WAPL cohesin release factor
chr1_+_81800368 0.91 ENST00000674489.1
ENST00000674442.1
ENST00000674419.1
ENST00000674407.1
ENST00000674168.1
ENST00000674307.1
ENST00000674209.1
ENST00000370715.5
ENST00000370713.5
ENST00000319517.10
ENST00000627151.2
ENST00000370717.6
ADGRL2
adhesion G protein-coupled receptor L2
chr14_-_21437235 0.90 ENST00000430710.8
ENST00000646340.1
ENST00000646063.1
CHD8
chromodomain helicase DNA binding protein 8
chr21_-_33588624 0.85 ENST00000437395.5
ENST00000453626.5
ENST00000303113.10
ENST00000303071.10
ENST00000432378.5
DONSON
DNA replication fork stabilization factor DONSON
chr10_-_70888546 0.84 ENST00000299299.4
PCBD1
pterin-4 alpha-carbinolamine dehydratase 1
chr6_-_111483190 0.84 ENST00000368802.8
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr10_-_13348270 0.83 ENST00000378614.8
ENST00000327347.10
ENST00000545675.5
SEPHS1
selenophosphate synthetase 1
chr22_+_40951364 0.80 ENST00000216225.9
RBX1
ring-box 1
chr14_+_54567612 0.79 ENST00000251091.9
ENST00000392067.7
ENST00000631086.2
SAMD4A
sterile alpha motif domain containing 4A
chr16_+_53054973 0.79 ENST00000447540.6
ENST00000615216.4
ENST00000566029.5
CHD9
chromodomain helicase DNA binding protein 9
chr6_-_136289824 0.78 ENST00000527536.5
ENST00000529826.5
ENST00000531224.6
ENST00000353331.8
ENST00000628517.2
BCLAF1
BCL2 associated transcription factor 1
chr16_-_73048104 0.71 ENST00000268489.10
ZFHX3
zinc finger homeobox 3
chr8_-_115668966 0.71 ENST00000395715.8
TRPS1
transcriptional repressor GATA binding 1
chr14_-_57268810 0.67 ENST00000413566.6
ENST00000340918.11
ENST00000621441.5
EXOC5
exocyst complex component 5
chr2_+_46698909 0.67 ENST00000650611.1
ENST00000306503.5
LINC01118
SOCS5
long intergenic non-protein coding RNA 1118
suppressor of cytokine signaling 5
chr6_+_133953210 0.66 ENST00000367869.1
ENST00000237264.9
ENST00000674115.1
TBPL1
ENSG00000288529.1
TATA-box binding protein like 1
novel protein
chr3_+_37861926 0.66 ENST00000443503.6
CTDSPL
CTD small phosphatase like
chr4_-_65670339 0.65 ENST00000273854.7
EPHA5
EPH receptor A5
chr22_-_21867610 0.65 ENST00000215832.11
ENST00000398822.7
MAPK1
mitogen-activated protein kinase 1
chr20_-_543770 0.64 ENST00000460062.7
ENST00000645187.1
ENST00000647348.1
ENST00000217244.9
ENST00000349736.10
CSNK2A1
casein kinase 2 alpha 1
chrX_-_41922992 0.58 ENST00000646120.2
ENST00000421587.8
ENST00000644770.1
ENST00000645566.1
ENST00000378166.9
ENST00000378158.6
ENST00000644219.1
ENST00000442742.7
ENST00000644347.1
CASK
calcium/calmodulin dependent serine protein kinase
chr18_-_26090584 0.52 ENST00000415083.7
SS18
SS18 subunit of BAF chromatin remodeling complex
chr12_+_93571664 0.49 ENST00000622746.4
ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2
chr14_-_37595224 0.47 ENST00000250448.5
FOXA1
forkhead box A1
chr17_-_35089212 0.41 ENST00000584655.5
ENST00000447669.6
ENST00000315249.11
RFFL
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr3_-_98901656 0.41 ENST00000326840.11
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr17_+_50719565 0.39 ENST00000625349.2
ENST00000393227.6
ENST00000240304.5
ENST00000505658.6
ENST00000505619.5
ENST00000510984.5
LUC7L3
LUC7 like 3 pre-mRNA splicing factor
chr3_-_122514876 0.37 ENST00000493510.1
ENST00000476916.5
ENST00000344337.11
ENST00000465882.5
KPNA1
karyopherin subunit alpha 1
chr12_+_72272360 0.35 ENST00000547300.2
ENST00000261180.10
TRHDE
thyrotropin releasing hormone degrading enzyme
chr3_+_196739839 0.31 ENST00000327134.7
PAK2
p21 (RAC1) activated kinase 2
chr9_-_136050502 0.31 ENST00000371753.5
NACC2
NACC family member 2
chr17_-_82273681 0.29 ENST00000392334.6
ENST00000314028.10
CSNK1D
casein kinase 1 delta
chr4_-_139177185 0.28 ENST00000394235.6
ELF2
E74 like ETS transcription factor 2
chrX_+_38801451 0.26 ENST00000378474.3
ENST00000336949.7
MID1IP1
MID1 interacting protein 1
chr11_+_95790459 0.24 ENST00000325486.9
ENST00000325542.10
ENST00000544522.5
ENST00000541365.5
CEP57
centrosomal protein 57
chr9_+_4679555 0.20 ENST00000381858.5
ENST00000381854.4
CDC37L1
cell division cycle 37 like 1
chr12_-_389249 0.20 ENST00000535014.5
ENST00000543507.1
ENST00000544760.1
ENST00000399788.7
KDM5A
lysine demethylase 5A
chr20_-_57710001 0.20 ENST00000341744.8
PMEPA1
prostate transmembrane protein, androgen induced 1
chr5_-_137754327 0.19 ENST00000314940.7
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr12_-_6607334 0.19 ENST00000645645.1
ENST00000357008.7
ENST00000544484.6
ENST00000544040.7
CHD4
chromodomain helicase DNA binding protein 4
chr11_+_35662739 0.19 ENST00000299413.7
TRIM44
tripartite motif containing 44
chr7_-_519239 0.18 ENST00000354513.9
ENST00000402802.7
PDGFA
platelet derived growth factor subunit A
chr3_-_115071333 0.18 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_243255170 0.17 ENST00000366542.6
CEP170
centrosomal protein 170
chr8_-_28386417 0.17 ENST00000521185.5
ENST00000520290.5
ENST00000344423.10
ZNF395
zinc finger protein 395
chr2_-_11344580 0.15 ENST00000616279.4
ENST00000315872.11
ROCK2
Rho associated coiled-coil containing protein kinase 2
chr4_-_56435581 0.14 ENST00000264220.6
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr12_-_54280087 0.13 ENST00000209875.9
CBX5
chromobox 5
chr3_-_116445458 0.11 ENST00000490035.7
LSAMP
limbic system associated membrane protein
chrX_-_120560947 0.11 ENST00000674137.11
ENST00000371322.11
ENST00000681090.1
CUL4B
cullin 4B
chr5_-_84384871 0.09 ENST00000296591.10
EDIL3
EGF like repeats and discoidin domains 3
chr10_+_100745711 0.08 ENST00000370296.6
ENST00000428433.5
PAX2
paired box 2
chr14_+_85530127 0.07 ENST00000330753.6
FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_+_77420880 0.05 ENST00000336216.9
ENST00000558176.1
HMG20A
high mobility group 20A
chr20_+_58651228 0.04 ENST00000361830.7
ENST00000458280.5
ENST00000355957.9
ENST00000312283.12
ENST00000412911.5
ENST00000359617.8
ENST00000371141.8
STX16
syntaxin 16
chr3_+_14125042 0.04 ENST00000306077.5
TMEM43
transmembrane protein 43
chr7_-_99144053 0.03 ENST00000361125.1
ENST00000361368.7
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr15_+_64151706 0.02 ENST00000325881.9
SNX22
sorting nexin 22

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.2 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
1.5 5.8 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
1.1 3.2 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
1.0 3.1 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
1.0 4.2 GO:0002188 translation reinitiation(GO:0002188)
0.9 5.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.8 5.5 GO:0051541 elastin metabolic process(GO:0051541)
0.7 3.3 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.7 2.6 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.6 3.9 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.5 2.0 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.5 6.4 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.5 1.4 GO:0061445 endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445)
0.5 3.8 GO:2000210 positive regulation of anoikis(GO:2000210)
0.5 1.4 GO:0090176 microtubule cytoskeleton organization involved in establishment of planar polarity(GO:0090176)
0.4 1.3 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.4 2.9 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.4 1.5 GO:0051586 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.4 1.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.4 1.5 GO:0009956 radial pattern formation(GO:0009956)
0.4 2.5 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.4 1.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752)
0.3 1.4 GO:1904835 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.3 0.9 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) regulation of chromosome condensation(GO:0060623) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.3 1.1 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.2 2.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.2 1.2 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.2 1.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.2 2.4 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.2 2.0 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 0.7 GO:0019858 cytosine metabolic process(GO:0019858)
0.2 3.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 1.3 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2 2.4 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.2 1.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.2 1.6 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.2 1.4 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.2 1.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 2.1 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.1 0.7 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.7 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.8 GO:0010265 SCF complex assembly(GO:0010265)
0.1 3.8 GO:0006465 signal peptide processing(GO:0006465)
0.1 1.8 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.1 0.5 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 3.8 GO:0006337 nucleosome disassembly(GO:0006337) negative regulation of histone acetylation(GO:0035067)
0.1 0.7 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 1.9 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 0.7 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.1 3.3 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 2.3 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 0.8 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 0.8 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 0.9 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 2.4 GO:2000637 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.1 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.0 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1 1.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 1.8 GO:0003016 respiratory system process(GO:0003016)
0.0 0.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.2 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.2 GO:0072553 terminal button organization(GO:0072553)
0.0 2.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.7 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 1.9 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 1.9 GO:0008542 visual learning(GO:0008542)
0.0 0.8 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 1.2 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 3.8 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.8 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.8 GO:0033260 nuclear DNA replication(GO:0033260)
0.0 0.1 GO:0021634 optic nerve formation(GO:0021634) optic chiasma development(GO:0061360) nephric duct formation(GO:0072179) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597)
0.0 0.3 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 1.3 GO:0090109 regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.3 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.7 GO:0006893 Golgi to plasma membrane transport(GO:0006893)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.6 1.8 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.4 3.8 GO:0005787 signal peptidase complex(GO:0005787)
0.4 1.2 GO:0018444 translation release factor complex(GO:0018444)
0.4 1.4 GO:0048179 activin receptor complex(GO:0048179)
0.3 2.4 GO:0031415 NatA complex(GO:0031415)
0.3 3.3 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.3 1.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2 3.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.2 1.3 GO:0044326 dendritic spine neck(GO:0044326)
0.1 1.4 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 1.4 GO:0097443 sorting endosome(GO:0097443)
0.1 0.8 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.1 1.6 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 1.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 7.5 GO:0043034 costamere(GO:0043034)
0.1 2.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.9 GO:0008278 cohesin complex(GO:0008278)
0.1 1.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 4.2 GO:0002102 podosome(GO:0002102)
0.1 0.7 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 1.3 GO:0032433 filopodium tip(GO:0032433)
0.1 1.4 GO:0016342 catenin complex(GO:0016342)
0.1 4.1 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.8 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 6.4 GO:0043195 terminal bouton(GO:0043195)
0.1 4.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 4.8 GO:0030175 filopodium(GO:0030175)
0.0 2.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 3.6 GO:0005811 lipid particle(GO:0005811)
0.0 3.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.6 GO:0005652 nuclear lamina(GO:0005652)
0.0 2.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.7 GO:0055037 recycling endosome(GO:0055037)
0.0 2.5 GO:0043204 perikaryon(GO:0043204)
0.0 0.5 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 2.0 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.2 GO:0030315 T-tubule(GO:0030315)
0.0 5.2 GO:0045121 membrane raft(GO:0045121)
0.0 2.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.7 GO:0005902 microvillus(GO:0005902)
0.0 0.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.8 2.5 GO:0004766 spermidine synthase activity(GO:0004766)
0.8 3.8 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.7 3.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.4 5.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.4 1.6 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.4 1.1 GO:0070052 collagen V binding(GO:0070052)
0.3 2.6 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.2 1.4 GO:0016361 activin receptor activity, type I(GO:0016361)
0.2 1.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 0.9 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.2 0.8 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.2 2.4 GO:0033592 RNA strand annealing activity(GO:0033592)
0.2 1.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 2.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 1.4 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 6.4 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 3.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.0 GO:0043426 MRF binding(GO:0043426)
0.1 5.0 GO:0050699 WW domain binding(GO:0050699)
0.1 1.4 GO:0034452 dynactin binding(GO:0034452)
0.1 1.1 GO:0031386 protein tag(GO:0031386)
0.1 5.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 4.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 3.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 3.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.9 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 3.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.1 1.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 3.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 4.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.5 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 2.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 3.0 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.8 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.9 GO:0001972 retinoic acid binding(GO:0001972)
0.0 2.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 2.6 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.0 GO:0004386 helicase activity(GO:0004386)
0.0 2.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 4.3 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.4 PID ALK2 PATHWAY ALK2 signaling events
0.1 6.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 7.2 PID BMP PATHWAY BMP receptor signaling
0.1 4.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 6.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 1.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 2.0 PID ARF 3PATHWAY Arf1 pathway
0.1 4.8 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 5.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 4.4 PID E2F PATHWAY E2F transcription factor network
0.0 1.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.1 PID FOXO PATHWAY FoxO family signaling
0.0 2.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.8 PID P73PATHWAY p73 transcription factor network
0.0 0.5 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 5.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 9.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 5.8 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 3.1 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 4.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 5.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.5 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 2.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 0.7 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 3.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 7.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis