Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GUAGUGU

Z-value: 0.88

Motif logo

logo of

miRNA associated with seed GUAGUGU

NamemiRBASE accession
hsa-miR-142-3p.1
MIMAT0000434

Activity profile of GUAGUGU motif

Sorted Z-values of GUAGUGU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GUAGUGU

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_38867789 15.30 ENST00000358869.5
FAM114A1
family with sequence similarity 114 member A1
chr2_+_186590022 14.24 ENST00000261023.8
ENST00000374907.7
ITGAV
integrin subunit alpha V
chr3_-_123884290 10.41 ENST00000346322.9
ENST00000360772.7
ENST00000360304.8
MYLK
myosin light chain kinase
chrX_+_135032346 9.40 ENST00000257013.9
RTL8C
retrotransposon Gag like 8C
chr5_+_95731300 9.10 ENST00000379982.8
RHOBTB3
Rho related BTB domain containing 3
chr22_-_35840218 8.83 ENST00000414461.6
ENST00000416721.6
ENST00000449924.6
ENST00000262829.11
ENST00000397305.3
RBFOX2
RNA binding fox-1 homolog 2
chr12_-_43806249 8.72 ENST00000548315.5
ENST00000552521.5
ENST00000546662.5
ENST00000548403.1
ENST00000546506.5
ENST00000395510.7
TWF1
twinfilin actin binding protein 1
chr2_-_86563382 8.19 ENST00000263856.9
CHMP3
charged multivesicular body protein 3
chr12_+_65824475 7.93 ENST00000403681.7
HMGA2
high mobility group AT-hook 2
chr6_-_30744537 7.69 ENST00000259874.6
ENST00000376377.2
IER3
immediate early response 3
chr11_+_9384621 7.65 ENST00000379719.8
ENST00000527431.1
ENST00000630083.1
IPO7
importin 7
chr10_+_61901678 7.14 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr2_+_197500398 7.00 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr11_+_57753243 6.33 ENST00000524630.5
ENST00000529919.5
ENST00000533189.1
CTNND1
catenin delta 1
chr17_-_8630713 6.21 ENST00000411957.1
ENST00000360416.8
MYH10
myosin heavy chain 10
chr3_+_100709473 6.05 ENST00000240851.9
ENST00000675243.1
ENST00000676111.1
ENST00000476228.5
ENST00000463568.6
ENST00000676395.1
TFG
trafficking from ER to golgi regulator
chr10_+_17644126 6.00 ENST00000377524.8
STAM
signal transducing adaptor molecule
chr1_-_77682639 5.82 ENST00000370801.8
ENST00000433749.5
ZZZ3
zinc finger ZZ-type containing 3
chr2_+_197515565 5.65 ENST00000233892.8
ENST00000409916.5
MOB4
MOB family member 4, phocein
chr6_-_134318097 5.51 ENST00000367858.10
ENST00000533224.1
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_7771263 5.34 ENST00000054666.11
VAMP3
vesicle associated membrane protein 3
chrX_-_154019800 5.15 ENST00000444230.5
ENST00000393687.6
ENST00000429936.6
ENST00000369974.6
ENST00000369980.8
IRAK1
interleukin 1 receptor associated kinase 1
chr6_+_34889228 5.11 ENST00000360359.5
ENST00000649117.1
ENST00000650178.1
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr7_+_6374491 4.95 ENST00000348035.9
ENST00000356142.4
RAC1
Rac family small GTPase 1
chr2_-_160493799 4.65 ENST00000348849.8
RBMS1
RNA binding motif single stranded interacting protein 1
chr10_-_79445617 4.62 ENST00000372336.4
ZCCHC24
zinc finger CCHC-type containing 24
chr9_-_14314067 4.62 ENST00000397575.7
NFIB
nuclear factor I B
chrX_-_135052114 4.60 ENST00000370775.3
RTL8A
retrotransposon Gag like 8A
chr1_+_24745396 4.42 ENST00000374379.9
CLIC4
chloride intracellular channel 4
chrX_-_103688033 4.31 ENST00000434230.5
ENST00000418819.5
ENST00000360458.5
MORF4L2
mortality factor 4 like 2
chr6_+_13615322 4.29 ENST00000451315.7
NOL7
nucleolar protein 7
chr2_+_9206762 4.21 ENST00000315273.4
ENST00000281419.8
ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr7_-_6484057 4.18 ENST00000490996.1
ENST00000258739.9
ENST00000436575.5
KDELR2
DAGLB
KDEL endoplasmic reticulum protein retention receptor 2
diacylglycerol lipase beta
chr1_+_224356852 4.03 ENST00000366858.7
ENST00000366857.9
ENST00000465271.6
ENST00000366856.3
CNIH4
cornichon family AMPA receptor auxiliary protein 4
chr19_-_17245889 3.94 ENST00000291442.4
NR2F6
nuclear receptor subfamily 2 group F member 6
chr21_-_43427131 3.77 ENST00000270162.8
SIK1
salt inducible kinase 1
chr2_-_65130090 3.71 ENST00000398529.7
ENST00000409751.1
ENST00000409892.5
ENST00000409784.8
RAB1A
RAB1A, member RAS oncogene family
chr1_+_93448155 3.69 ENST00000370253.6
FNBP1L
formin binding protein 1 like
chr1_-_205750167 3.69 ENST00000367142.5
NUCKS1
nuclear casein kinase and cyclin dependent kinase substrate 1
chr10_+_132537778 3.62 ENST00000368594.8
INPP5A
inositol polyphosphate-5-phosphatase A
chr6_+_53794948 3.46 ENST00000370888.6
LRRC1
leucine rich repeat containing 1
chr11_+_34621065 3.25 ENST00000257831.8
EHF
ETS homologous factor
chr12_-_117190456 3.21 ENST00000330622.9
ENST00000622495.5
ENST00000427718.6
FBXO21
F-box protein 21
chr7_-_151519891 3.19 ENST00000262187.10
RHEB
Ras homolog, mTORC1 binding
chr17_-_50397472 3.18 ENST00000576448.1
ENST00000225972.8
LRRC59
leucine rich repeat containing 59
chr11_+_70398404 2.89 ENST00000346329.7
ENST00000301843.13
ENST00000376561.7
CTTN
cortactin
chr16_-_66751591 2.87 ENST00000440564.6
ENST00000443351.6
ENST00000566150.5
ENST00000258198.7
DYNC1LI2
dynein cytoplasmic 1 light intermediate chain 2
chr3_+_156674579 2.80 ENST00000295924.12
TIPARP
TCDD inducible poly(ADP-ribose) polymerase
chr9_+_36190856 2.69 ENST00000433436.6
ENST00000538225.5
ENST00000540080.5
CLTA
clathrin light chain A
chr3_-_115071333 2.61 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_101407727 2.49 ENST00000539055.5
ENST00000551688.1
ENST00000551671.5
ENST00000261636.13
ARL1
ADP ribosylation factor like GTPase 1
chr8_+_60516947 2.48 ENST00000262646.12
RAB2A
RAB2A, member RAS oncogene family
chr4_-_128287785 2.39 ENST00000296425.10
PGRMC2
progesterone receptor membrane component 2
chr3_-_50359480 2.37 ENST00000266025.4
TMEM115
transmembrane protein 115
chr4_-_138242325 2.36 ENST00000280612.9
SLC7A11
solute carrier family 7 member 11
chr19_+_54190268 2.33 ENST00000429671.7
ENST00000302937.8
ENST00000667261.1
TSEN34
tRNA splicing endonuclease subunit 34
chr10_-_32056376 2.20 ENST00000302418.5
KIF5B
kinesin family member 5B
chr14_-_23034878 1.97 ENST00000493471.2
ENST00000460922.2
ENST00000361611.11
PSMB5
proteasome 20S subunit beta 5
chr20_-_47355657 1.95 ENST00000311275.11
ZMYND8
zinc finger MYND-type containing 8
chr3_-_177196451 1.80 ENST00000430069.5
ENST00000630796.2
ENST00000428970.5
TBL1XR1
TBL1X receptor 1
chr6_-_36986122 1.76 ENST00000460219.2
ENST00000373627.10
ENST00000373616.9
MTCH1
mitochondrial carrier 1
chr1_+_23743153 1.69 ENST00000418390.6
ELOA
elongin A
chr10_-_59906509 1.59 ENST00000263102.7
CCDC6
coiled-coil domain containing 6
chr1_+_115641945 1.58 ENST00000355485.7
ENST00000369510.8
VANGL1
VANGL planar cell polarity protein 1
chr16_-_4116403 1.58 ENST00000294016.8
ADCY9
adenylate cyclase 9
chr9_-_16870662 1.49 ENST00000380672.9
BNC2
basonuclin 2
chr7_-_106112205 1.48 ENST00000470347.1
ENST00000455385.7
SYPL1
synaptophysin like 1
chr5_-_134176920 1.41 ENST00000521216.5
ENST00000353411.11
ENST00000522855.5
ENST00000328392.10
ENST00000519321.5
SKP1
S-phase kinase associated protein 1
chr22_-_36387949 1.38 ENST00000216181.11
MYH9
myosin heavy chain 9
chr3_+_129249594 1.31 ENST00000314797.10
COPG1
COPI coat complex subunit gamma 1
chr15_+_84980440 1.24 ENST00000310298.8
ENST00000557957.5
PDE8A
phosphodiesterase 8A
chr2_-_39437264 1.20 ENST00000263881.8
ENST00000341681.9
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr11_-_86069043 1.20 ENST00000532317.5
ENST00000528256.1
ENST00000393346.8
ENST00000526033.5
PICALM
phosphatidylinositol binding clathrin assembly protein
chr1_+_32179665 1.17 ENST00000373610.8
TXLNA
taxilin alpha
chr5_+_42423433 1.12 ENST00000230882.9
GHR
growth hormone receptor
chr10_+_5684828 1.09 ENST00000328090.9
ENST00000496681.5
TASOR2
transcription activation suppressor family member 2
chr1_-_31065671 1.09 ENST00000440538.6
ENST00000424085.6
ENST00000257075.9
ENST00000373747.7
ENST00000426105.7
ENST00000525843.5
ENST00000373742.6
PUM1
pumilio RNA binding family member 1
chr7_+_100673732 1.07 ENST00000303210.9
ENST00000436220.5
ENST00000424361.5
GNB2
G protein subunit beta 2
chrX_+_28587411 1.06 ENST00000378993.6
IL1RAPL1
interleukin 1 receptor accessory protein like 1
chr5_-_115625972 1.05 ENST00000333314.3
ENST00000456936.4
TMED7-TICAM2
TMED7
TMED7-TICAM2 readthrough
transmembrane p24 trafficking protein 7
chr4_-_101347471 1.05 ENST00000323055.10
ENST00000512215.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr13_+_48975879 1.03 ENST00000492622.6
FNDC3A
fibronectin type III domain containing 3A
chr2_-_11344580 1.00 ENST00000616279.4
ENST00000315872.11
ROCK2
Rho associated coiled-coil containing protein kinase 2
chr2_-_61538313 0.98 ENST00000677803.1
ENST00000677239.1
ENST00000401558.7
XPO1
exportin 1
chr2_+_203328378 0.97 ENST00000430418.5
ENST00000261018.12
ENST00000295851.10
ENST00000424558.5
ENST00000417864.5
ENST00000422511.6
ABI2
abl interactor 2
chr1_+_86704564 0.88 ENST00000616170.4
ENST00000535010.5
ENST00000370558.8
SH3GLB1
SH3 domain containing GRB2 like, endophilin B1
chrX_-_41922992 0.87 ENST00000646120.2
ENST00000421587.8
ENST00000644770.1
ENST00000645566.1
ENST00000378166.9
ENST00000378158.6
ENST00000644219.1
ENST00000442742.7
ENST00000644347.1
CASK
calcium/calmodulin dependent serine protein kinase
chr11_-_65614195 0.80 ENST00000309100.8
ENST00000529839.1
ENST00000526293.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr6_-_33298909 0.79 ENST00000497454.6
RGL2
ral guanine nucleotide dissociation stimulator like 2
chr6_+_33620329 0.76 ENST00000374316.9
ITPR3
inositol 1,4,5-trisphosphate receptor type 3
chr20_-_31722533 0.75 ENST00000677194.1
ENST00000434194.2
ENST00000376062.6
BCL2L1
BCL2 like 1
chr1_+_218345326 0.73 ENST00000366930.9
TGFB2
transforming growth factor beta 2
chr7_-_41703062 0.68 ENST00000242208.5
INHBA
inhibin subunit beta A
chr15_+_65869535 0.66 ENST00000569896.1
RAB11A
RAB11A, member RAS oncogene family
chr14_-_31026363 0.65 ENST00000357479.10
ENST00000355683.9
STRN3
striatin 3
chrX_+_37349287 0.63 ENST00000466533.5
ENST00000542554.5
ENST00000543642.5
ENST00000484460.5
ENST00000378628.9
ENST00000449135.6
ENST00000463135.1
ENST00000465127.1
PRRG1
ENSG00000250349.3
proline rich and Gla domain 1
novel proline rich Gla (G-carboxyglutamic acid) 1 (PRRG1) and tetraspanin 7 (TSPAN7) protein
chrX_+_49922605 0.62 ENST00000376088.7
CLCN5
chloride voltage-gated channel 5
chr6_-_132513045 0.61 ENST00000367941.7
ENST00000367937.4
STX7
syntaxin 7
chr18_-_26090584 0.60 ENST00000415083.7
SS18
SS18 subunit of BAF chromatin remodeling complex
chr5_-_143403611 0.53 ENST00000394464.7
ENST00000231509.7
NR3C1
nuclear receptor subfamily 3 group C member 1
chr5_-_157059109 0.51 ENST00000523175.6
ENST00000522693.5
HAVCR1
hepatitis A virus cellular receptor 1
chr11_-_77820706 0.49 ENST00000440064.2
ENST00000528095.5
ENST00000308488.11
RSF1
remodeling and spacing factor 1
chr3_+_20040437 0.46 ENST00000263754.5
KAT2B
lysine acetyltransferase 2B
chr2_+_42169332 0.45 ENST00000402711.6
ENST00000318522.10
EML4
EMAP like 4
chr6_+_7107941 0.45 ENST00000379938.7
ENST00000467782.5
ENST00000334984.10
ENST00000349384.10
RREB1
ras responsive element binding protein 1
chr3_+_23945271 0.45 ENST00000312521.9
NR1D2
nuclear receptor subfamily 1 group D member 2
chr1_+_27773189 0.45 ENST00000373943.9
ENST00000440806.2
STX12
syntaxin 12
chr3_-_150546403 0.43 ENST00000239944.7
ENST00000491660.1
ENST00000487153.1
SERP1
stress associated endoplasmic reticulum protein 1
chr12_-_54188871 0.41 ENST00000504338.5
ENST00000514685.5
ENST00000504797.1
ENST00000513838.5
ENST00000505128.5
ENST00000337581.7
ENST00000503306.5
ENST00000243112.9
ENST00000514196.5
ENST00000682136.1
ENST00000506169.5
ENST00000507904.5
ENST00000508394.6
SMUG1
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr10_-_118046922 0.36 ENST00000355624.8
RAB11FIP2
RAB11 family interacting protein 2
chr2_+_147845020 0.31 ENST00000241416.12
ACVR2A
activin A receptor type 2A
chr14_+_64986846 0.30 ENST00000246166.3
FNTB
farnesyltransferase, CAAX box, beta
chr14_-_21269451 0.28 ENST00000336053.10
HNRNPC
heterogeneous nuclear ribonucleoprotein C
chr11_+_120336357 0.25 ENST00000397843.7
ARHGEF12
Rho guanine nucleotide exchange factor 12
chr7_-_123748902 0.20 ENST00000223023.5
WASL
WASP like actin nucleation promoting factor
chr18_-_36067524 0.20 ENST00000590898.5
ENST00000357384.8
ENST00000399022.9
ENST00000588737.5
RPRD1A
regulation of nuclear pre-mRNA domain containing 1A
chr13_-_30464234 0.15 ENST00000399489.5
ENST00000339872.8
HMGB1
high mobility group box 1
chr16_-_74666839 0.13 ENST00000576652.1
ENST00000572337.5
ENST00000571750.5
ENST00000572990.5
ENST00000361070.9
RFWD3
ring finger and WD repeat domain 3
chr10_-_15719885 0.13 ENST00000378076.4
ITGA8
integrin subunit alpha 8
chr11_-_76670737 0.10 ENST00000260061.9
ENST00000404995.5
LRRC32
leucine rich repeat containing 32
chr6_-_31660735 0.09 ENST00000375911.2
C6orf47
chromosome 6 open reading frame 47
chr2_-_152175715 0.09 ENST00000263904.5
STAM2
signal transducing adaptor molecule 2
chr3_+_152835122 0.08 ENST00000305097.6
P2RY1
purinergic receptor P2Y1
chr6_-_73653913 0.06 ENST00000355773.6
SLC17A5
solute carrier family 17 member 5
chr11_+_126283059 0.04 ENST00000392679.6
ENST00000392678.7
ENST00000392680.6
TIRAP
TIR domain containing adaptor protein
chr4_-_16084002 0.02 ENST00000447510.7
PROM1
prominin 1
chr15_+_78872809 0.01 ENST00000331268.9
MORF4L1
mortality factor 4 like 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
2.6 7.9 GO:0090402 oncogene-induced cell senescence(GO:0090402)
2.2 8.7 GO:0030047 actin modification(GO:0030047)
2.1 6.2 GO:0021592 fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
1.7 5.0 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
1.6 9.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.3 8.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
1.2 3.7 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.8 8.2 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.8 5.5 GO:0070294 renal sodium ion absorption(GO:0070294)
0.8 3.8 GO:0032792 negative regulation of triglyceride biosynthetic process(GO:0010868) negative regulation of CREB transcription factor activity(GO:0032792)
0.8 6.0 GO:1903551 regulation of extracellular exosome assembly(GO:1903551)
0.7 5.3 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.6 5.1 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.6 2.3 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.5 1.9 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.5 1.4 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
0.4 0.9 GO:1903778 protein localization to vacuolar membrane(GO:1903778)
0.4 4.6 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 4.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.4 4.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.4 2.2 GO:0035617 stress granule disassembly(GO:0035617)
0.3 3.2 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.3 5.3 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.3 2.5 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.3 2.9 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.3 1.0 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.3 1.0 GO:1903347 positive regulation of centrosome duplication(GO:0010825) negative regulation of bicellular tight junction assembly(GO:1903347)
0.2 0.7 GO:0051795 negative regulation of alkaline phosphatase activity(GO:0010693) uterine wall breakdown(GO:0042704) positive regulation of catagen(GO:0051795)
0.2 3.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 0.7 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 3.0 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.2 1.8 GO:0060613 fat pad development(GO:0060613)
0.2 1.2 GO:0035459 cargo loading into vesicle(GO:0035459)
0.2 0.8 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.2 7.1 GO:0060612 adipose tissue development(GO:0060612)
0.2 3.6 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.2 6.3 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.2 0.7 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.2 1.1 GO:0000255 allantoin metabolic process(GO:0000255)
0.2 4.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 3.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.2 1.4 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.4 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.8 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 1.0 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.1 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 0.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 1.1 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 2.7 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.1 0.8 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 8.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 1.0 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 20.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 1.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 2.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 0.6 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.1 0.5 GO:0016584 nucleosome positioning(GO:0016584)
0.1 1.6 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.1 0.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 1.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.5 GO:0043586 tongue development(GO:0043586)
0.1 0.9 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 2.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 1.0 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 1.2 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.4 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.8 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.4 GO:0045008 depyrimidination(GO:0045008)
0.0 0.6 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 5.7 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 8.1 GO:0006457 protein folding(GO:0006457)
0.0 3.0 GO:0090175 Wnt signaling pathway, planar cell polarity pathway(GO:0060071) regulation of establishment of planar polarity(GO:0090175)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.4 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 0.6 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 3.8 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)
0.0 0.3 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.3 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
2.0 6.1 GO:0033565 ESCRT-0 complex(GO:0033565)
1.7 5.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
1.5 7.6 GO:0097513 myosin II filament(GO:0097513)
1.1 7.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.6 8.2 GO:0000815 ESCRT III complex(GO:0000815)
0.5 6.3 GO:0005915 zonula adherens(GO:0005915)
0.5 2.3 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.4 1.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.3 6.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.3 2.7 GO:0071439 clathrin complex(GO:0071439)
0.2 1.2 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 1.4 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.2 0.7 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.2 2.2 GO:0035253 ciliary rootlet(GO:0035253)
0.2 4.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 6.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 2.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 2.9 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 2.4 GO:0017119 Golgi transport complex(GO:0017119)
0.2 14.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 1.0 GO:0005642 annulate lamellae(GO:0005642)
0.2 11.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.7 GO:0070449 elongin complex(GO:0070449)
0.1 2.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 4.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.1 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.1 1.5 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 2.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 9.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.1 0.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 4.4 GO:0005902 microvillus(GO:0005902)
0.1 11.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 7.6 GO:0005643 nuclear pore(GO:0005643)
0.1 7.8 GO:0030175 filopodium(GO:0030175)
0.1 0.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 3.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.9 GO:0005652 nuclear lamina(GO:0005652)
0.0 4.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 1.1 GO:0031201 SNARE complex(GO:0031201)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 2.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 1.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 3.5 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.2 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
2.6 10.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.6 7.9 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
1.4 4.2 GO:0005046 KDEL sequence binding(GO:0005046)
0.9 5.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.7 5.0 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.6 2.3 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.6 2.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.5 2.4 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.5 8.2 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.4 4.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.4 3.6 GO:0042731 inositol-polyphosphate 5-phosphatase activity(GO:0004445) PH domain binding(GO:0042731)
0.3 7.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 3.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 3.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 3.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 2.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 0.8 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 0.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 8.0 GO:0003785 actin monomer binding(GO:0003785)
0.2 8.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 5.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 4.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 2.9 GO:0005522 profilin binding(GO:0005522)
0.1 1.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.0 GO:0034711 inhibin binding(GO:0034711)
0.1 0.5 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 1.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 0.4 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 4.3 GO:0032452 histone demethylase activity(GO:0032452)
0.1 4.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 4.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 2.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 1.2 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.8 GO:0051434 BH3 domain binding(GO:0051434)
0.1 1.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 16.2 GO:0003924 GTPase activity(GO:0003924)
0.0 6.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 4.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 14.0 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.3 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 7.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.4 GO:0005496 steroid binding(GO:0005496)
0.0 1.0 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.0 GO:0035662 Toll-like receptor 4 binding(GO:0035662) Toll-like receptor 2 binding(GO:0035663)
0.0 1.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 19.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.3 15.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 11.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 5.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 9.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 2.7 PID ARF 3PATHWAY Arf1 pathway
0.1 8.7 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 6.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 4.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 4.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 3.1 PID LKB1 PATHWAY LKB1 signaling events
0.1 1.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.7 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.8 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.6 5.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.6 14.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 13.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 10.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 6.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 1.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 4.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.2 REACTOME KINESINS Genes involved in Kinesins
0.1 0.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 2.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 2.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 2.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 3.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.4 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 0.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.0 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation