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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GZF1

Z-value: 3.54

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Transcription factors associated with GZF1

Gene Symbol Gene ID Gene Info
GZF1
ENSG00000125812.16 GZF1

Activity profile of GZF1 motif

Sorted Z-values of GZF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GZF1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_26280117 28.04 ENST00000319041.6
SH3BGRL3
SH3 domain binding glutamate rich protein like 3
chr1_+_26280059 25.23 ENST00000270792.10
SH3BGRL3
SH3 domain binding glutamate rich protein like 3
chr5_+_171387757 22.26 ENST00000677297.1
ENST00000521672.6
ENST00000679190.1
ENST00000351986.10
ENST00000676589.1
ENST00000679233.1
ENST00000677357.1
ENST00000296930.10
ENST00000393820.2
ENST00000523622.1
NPM1
nucleophosmin 1
chr1_+_32292067 13.86 ENST00000373548.8
ENST00000428704.1
HDAC1
histone deacetylase 1
chr2_-_149587602 13.24 ENST00000428879.5
ENST00000303319.10
ENST00000422782.2
MMADHC
metabolism of cobalamin associated D
chr6_-_36547400 11.50 ENST00000229812.8
STK38
serine/threonine kinase 38
chr15_+_41286011 11.47 ENST00000661438.1
ENSG00000285920.2
novel protein
chr7_+_5045821 10.65 ENST00000353796.7
ENST00000396912.2
ENST00000396904.2
RBAK
RBAK-RBAKDN
RB associated KRAB zinc finger
RBAK-RBAKDN readthrough
chr14_+_20989968 10.48 ENST00000382985.8
ENST00000339374.11
ENST00000556670.6
ENST00000553564.5
ENST00000554751.5
ENST00000554283.1
ENST00000555670.1
METTL17
methyltransferase like 17
chr12_-_102120065 10.44 ENST00000552283.6
ENST00000551744.2
NUP37
nucleoporin 37
chr22_-_42959852 8.84 ENST00000402229.5
ENST00000407585.5
ENST00000453079.1
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr1_+_78649818 8.62 ENST00000370747.9
ENST00000438486.1
IFI44
interferon induced protein 44
chr4_+_26343156 8.11 ENST00000680928.1
ENST00000681260.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr3_+_30606574 7.83 ENST00000295754.10
ENST00000359013.4
TGFBR2
transforming growth factor beta receptor 2
chr6_-_33080710 7.31 ENST00000419277.5
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr6_+_33080445 7.26 ENST00000428835.5
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr10_-_102120246 6.74 ENST00000425280.2
LDB1
LIM domain binding 1
chr10_+_92593112 6.65 ENST00000260731.5
KIF11
kinesin family member 11
chr14_-_21511290 6.58 ENST00000298717.9
METTL3
methyltransferase like 3
chr4_-_47463649 6.49 ENST00000381571.6
COMMD8
COMM domain containing 8
chr16_+_67842277 6.08 ENST00000303596.3
THAP11
THAP domain containing 11
chr7_-_26864573 6.05 ENST00000345317.7
SKAP2
src kinase associated phosphoprotein 2
chr1_+_9651723 6.00 ENST00000377346.9
ENST00000536656.5
ENST00000628140.2
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
chr10_-_125160499 5.77 ENST00000494626.6
ENST00000337195.9
CTBP2
C-terminal binding protein 2
chr10_-_102120318 5.53 ENST00000673968.1
LDB1
LIM domain binding 1
chr3_-_79767987 5.24 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr7_-_93890160 5.11 ENST00000451238.1
TFPI2
tissue factor pathway inhibitor 2
chr11_+_65572349 4.95 ENST00000316409.2
ENST00000449319.2
ENST00000530349.2
FAM89B
family with sequence similarity 89 member B
chrX_+_81202066 4.75 ENST00000373212.6
SH3BGRL
SH3 domain binding glutamate rich protein like
chr10_-_125161019 4.72 ENST00000411419.6
CTBP2
C-terminal binding protein 2
chr9_+_128371343 4.42 ENST00000372850.5
ENST00000372847.1
ENST00000372853.9
ENST00000483206.2
URM1
ubiquitin related modifier 1
chr19_+_926001 4.24 ENST00000263620.8
ARID3A
AT-rich interaction domain 3A
chr3_+_51671175 4.16 ENST00000614067.4
ENST00000457573.5
ENST00000611400.4
ENST00000412249.5
ENST00000425781.5
ENST00000341333.10
ENST00000415259.5
ENST00000395057.5
ENST00000416589.5
TEX264
testis expressed 264, ER-phagy receptor
chr1_-_226186673 3.46 ENST00000366812.6
ACBD3
acyl-CoA binding domain containing 3
chr1_+_40709475 3.27 ENST00000372651.5
NFYC
nuclear transcription factor Y subunit gamma
chr1_+_40709316 3.09 ENST00000372652.5
NFYC
nuclear transcription factor Y subunit gamma
chrX_+_54809060 2.73 ENST00000396224.1
MAGED2
MAGE family member D2
chr10_+_58269132 2.38 ENST00000333926.6
CISD1
CDGSH iron sulfur domain 1
chr1_-_41918858 2.17 ENST00000372583.6
HIVEP3
HIVEP zinc finger 3
chr17_-_31321743 2.11 ENST00000247270.3
EVI2A
ecotropic viral integration site 2A
chr19_-_3786254 2.01 ENST00000585778.5
MATK
megakaryocyte-associated tyrosine kinase
chr19_-_58573555 1.69 ENST00000599369.5
MZF1
myeloid zinc finger 1
chr19_-_58573280 1.53 ENST00000594234.5
ENST00000596039.1
ENST00000215057.7
MZF1
myeloid zinc finger 1
chr1_-_32336224 1.33 ENST00000329421.8
MARCKSL1
MARCKS like 1
chr9_+_134326435 1.08 ENST00000481739.2
RXRA
retinoid X receptor alpha
chr14_+_49620750 1.00 ENST00000305386.4
MGAT2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
chr19_+_12995467 0.90 ENST00000592199.6
NFIX
nuclear factor I X
chr8_-_56113982 0.82 ENST00000311923.1
MOS
MOS proto-oncogene, serine/threonine kinase
chr19_+_35666515 0.74 ENST00000617999.4
ENST00000616789.4
UPK1A
uroplakin 1A
chr1_-_41918666 0.72 ENST00000372584.5
HIVEP3
HIVEP zinc finger 3
chr19_-_3786408 0.40 ENST00000395040.6
MATK
megakaryocyte-associated tyrosine kinase
chr19_+_12995554 0.33 ENST00000397661.6
NFIX
nuclear factor I X
chr12_+_102120172 0.30 ENST00000327680.7
ENST00000541394.5
ENST00000543784.5
PARPBP
PARP1 binding protein
chr14_-_52069039 0.19 ENST00000216286.10
NID2
nidogen 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.3 GO:0043973 histone H3-K4 acetylation(GO:0043973)
2.6 7.8 GO:0060434 bronchus morphogenesis(GO:0060434)
2.5 22.3 GO:0060699 regulation of endoribonuclease activity(GO:0060699)
2.0 13.9 GO:0061198 fungiform papilla formation(GO:0061198)
1.7 5.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
1.3 5.2 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
1.2 6.0 GO:0060374 positive regulation of neutrophil apoptotic process(GO:0033031) mast cell differentiation(GO:0060374)
1.2 8.1 GO:1901189 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
1.1 4.4 GO:0034227 tRNA thio-modification(GO:0034227)
1.1 6.6 GO:1903679 regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
1.0 10.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.9 8.8 GO:0070836 caveola assembly(GO:0070836)
0.7 53.3 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.5 13.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.4 2.7 GO:0070294 renal sodium ion absorption(GO:0070294)
0.4 1.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.3 6.7 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.3 0.8 GO:0051295 meiotic cell cycle phase transition(GO:0044771) establishment of meiotic spindle localization(GO:0051295) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.2 10.4 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 14.6 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.1 5.1 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.1 10.0 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.1 6.4 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 2.4 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 1.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 4.2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 2.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 10.5 GO:0032259 methylation(GO:0032259)
0.0 4.2 GO:0002576 platelet degranulation(GO:0002576)
0.0 3.5 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 6.1 GO:0042113 B cell activation(GO:0042113)
0.0 1.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 6.4 GO:0009615 response to virus(GO:0009615)
0.0 14.4 GO:0045892 negative regulation of transcription, DNA-templated(GO:0045892)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.6 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
1.3 7.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
1.1 22.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.9 8.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.8 14.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.7 13.9 GO:0016580 Sin3 complex(GO:0016580)
0.7 10.5 GO:0097470 ribbon synapse(GO:0097470)
0.6 6.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.6 10.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 6.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 50.5 GO:0030027 lamellipodium(GO:0030027)
0.1 8.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 6.7 GO:0005871 kinesin complex(GO:0005871)
0.1 6.1 GO:0045171 intercellular bridge(GO:0045171)
0.1 6.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 12.3 GO:0031252 cell leading edge(GO:0031252)
0.0 10.5 GO:0005840 ribosome(GO:0005840)
0.0 4.2 GO:0045121 membrane raft(GO:0045121)
0.0 2.4 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 22.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
3.3 53.3 GO:0030215 semaphorin receptor binding(GO:0030215)
2.6 7.8 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
2.2 6.6 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
1.5 10.5 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
1.4 12.3 GO:0030274 LIM domain binding(GO:0030274)
0.9 13.9 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.7 5.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.6 11.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.6 6.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.5 7.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.5 8.1 GO:0000150 recombinase activity(GO:0000150)
0.4 1.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.3 8.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.3 4.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.3 5.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 6.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 7.3 GO:0042605 peptide antigen binding(GO:0042605)
0.2 3.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 2.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 10.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 6.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 9.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 5.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 10.5 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.0 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 10.6 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.4 22.3 PID BARD1 PATHWAY BARD1 signaling events
0.2 6.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 7.8 PID ALK1 PATHWAY ALK1 signaling events
0.1 8.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 8.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 5.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 10.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 22.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.7 14.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.5 8.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 13.9 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.4 7.8 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 10.4 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2 6.7 REACTOME KINESINS Genes involved in Kinesins
0.2 5.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 6.0 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 6.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 6.6 REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.0 1.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi