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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HAND1

Z-value: 0.17

Motif logo

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Transcription factors associated with HAND1

Gene Symbol Gene ID Gene Info
HAND1
ENSG00000113196.3 HAND1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAND1hg38_v1_chr5_-_154478218_1544782340.212.0e-03Click!

Activity profile of HAND1 motif

Sorted Z-values of HAND1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_35868585 4.59 ENST00000652533.1
APLP1
amyloid beta precursor like protein 1
chr11_-_5243644 4.50 ENST00000643122.1
HBD
hemoglobin subunit delta
chr19_+_35868518 4.38 ENST00000221891.9
APLP1
amyloid beta precursor like protein 1
chr4_+_25160631 4.35 ENST00000510415.1
ENST00000507794.2
ENST00000512921.4
SEPSECS-AS1
PI4K2B
SEPSECS antisense RNA 1 (head to head)
phosphatidylinositol 4-kinase type 2 beta
chr19_-_37210484 3.75 ENST00000527838.5
ENST00000591492.5
ENST00000532828.7
ZNF585B
zinc finger protein 585B
chr1_+_65309517 3.70 ENST00000371069.5
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr5_+_36608146 3.64 ENST00000381918.4
ENST00000513646.1
SLC1A3
solute carrier family 1 member 3
chr10_+_5048748 3.57 ENST00000602997.5
ENST00000439082.7
AKR1C3
aldo-keto reductase family 1 member C3
chr14_-_64942720 3.05 ENST00000557049.1
ENST00000389614.6
GPX2
glutathione peroxidase 2
chr14_-_64942783 2.94 ENST00000612794.1
GPX2
glutathione peroxidase 2
chr10_-_5003850 2.89 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
AKR1C2
aldo-keto reductase family 1 member C2
chr1_-_110064916 2.75 ENST00000649954.1
ALX3
ALX homeobox 3
chr2_+_209579399 2.54 ENST00000360351.8
MAP2
microtubule associated protein 2
chr16_-_28610032 2.52 ENST00000567512.1
SULT1A1
sulfotransferase family 1A member 1
chr20_+_46029165 2.42 ENST00000616201.4
ENST00000616202.4
ENST00000616933.4
ENST00000626937.2
SLC12A5
solute carrier family 12 member 5
chr16_+_6019585 2.38 ENST00000547372.5
RBFOX1
RNA binding fox-1 homolog 1
chr4_+_41613476 2.37 ENST00000508466.1
LIMCH1
LIM and calponin homology domains 1
chr4_+_41612892 2.29 ENST00000509454.5
ENST00000396595.7
ENST00000381753.8
LIMCH1
LIM and calponin homology domains 1
chr16_-_28609992 2.25 ENST00000314752.11
SULT1A1
sulfotransferase family 1A member 1
chr17_-_66220630 2.16 ENST00000585162.1
APOH
apolipoprotein H
chr2_+_209579598 2.16 ENST00000445941.5
ENST00000673860.1
MAP2
microtubule associated protein 2
chr2_+_209579429 2.14 ENST00000361559.8
MAP2
microtubule associated protein 2
chr11_+_125063295 1.93 ENST00000532000.5
ENST00000403796.7
ENST00000308074.4
SLC37A2
solute carrier family 37 member 2
chr2_-_27495185 1.86 ENST00000264703.4
FNDC4
fibronectin type III domain containing 4
chr11_-_2301859 1.82 ENST00000456145.2
ENST00000381153.8
C11orf21
chromosome 11 open reading frame 21
chr16_-_28597042 1.79 ENST00000533150.5
ENST00000335715.9
SULT1A2
sulfotransferase family 1A member 2
chr12_+_40692413 1.77 ENST00000551295.7
ENST00000547702.5
ENST00000551424.5
CNTN1
contactin 1
chr16_-_28609976 1.71 ENST00000566189.5
SULT1A1
sulfotransferase family 1A member 1
chr11_+_2302119 1.68 ENST00000381121.7
TSPAN32
tetraspanin 32
chr1_-_52404387 1.64 ENST00000371566.1
ENST00000371568.8
ORC1
origin recognition complex subunit 1
chr4_+_41612702 1.63 ENST00000509277.5
LIMCH1
LIM and calponin homology domains 1
chr1_+_45012691 1.56 ENST00000469548.5
UROD
uroporphyrinogen decarboxylase
chr17_-_44947637 1.55 ENST00000587309.5
ENST00000593135.6
KIF18B
kinesin family member 18B
chr18_-_46757012 1.54 ENST00000315087.12
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr1_+_27935022 1.53 ENST00000411604.5
ENST00000373888.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr18_-_46756791 1.46 ENST00000538168.5
ENST00000536490.1
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr11_+_72114840 1.42 ENST00000622388.4
FOLR3
folate receptor gamma
chr1_+_207089195 1.42 ENST00000452902.6
C4BPB
complement component 4 binding protein beta
chr17_-_8210203 1.41 ENST00000578549.5
ENST00000582368.5
AURKB
aurora kinase B
chr1_+_45012896 1.40 ENST00000428106.1
UROD
uroporphyrinogen decarboxylase
chr1_+_174877430 1.39 ENST00000392064.6
RABGAP1L
RAB GTPase activating protein 1 like
chr2_+_113058637 1.36 ENST00000346807.7
IL36RN
interleukin 36 receptor antagonist
chr1_+_43979179 1.31 ENST00000434555.7
ENST00000372324.6
ENST00000481924.2
B4GALT2
beta-1,4-galactosyltransferase 2
chr10_+_116590956 1.26 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr12_+_49323236 1.23 ENST00000549275.5
ENST00000551245.5
ENST00000380327.9
ENST00000548311.5
ENST00000257909.8
ENST00000550346.5
ENST00000550709.5
ENST00000549534.1
ENST00000547807.5
ENST00000551567.1
TROAP
trophinin associated protein
chrX_+_71144818 1.22 ENST00000536169.5
ENST00000358741.4
ENST00000395855.6
ENST00000374051.7
NLGN3
neuroligin 3
chr3_+_124094663 1.20 ENST00000460856.5
ENST00000240874.7
KALRN
kalirin RhoGEF kinase
chr1_+_207089233 1.19 ENST00000243611.9
ENST00000367076.7
C4BPB
complement component 4 binding protein beta
chr6_+_101181254 1.19 ENST00000682090.1
ENST00000421544.6
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr1_+_207089283 1.18 ENST00000391923.1
C4BPB
complement component 4 binding protein beta
chr10_+_116591010 1.14 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr16_+_6019663 1.13 ENST00000422070.8
RBFOX1
RNA binding fox-1 homolog 1
chr10_-_116273606 1.13 ENST00000682743.1
GFRA1
GDNF family receptor alpha 1
chr11_-_63563370 1.10 ENST00000255695.2
PLAAT2
phospholipase A and acyltransferase 2
chr7_-_151057848 1.10 ENST00000297518.4
CDK5
cyclin dependent kinase 5
chr7_+_111091119 1.08 ENST00000308478.10
LRRN3
leucine rich repeat neuronal 3
chr7_-_151057880 1.08 ENST00000485972.6
CDK5
cyclin dependent kinase 5
chr14_+_96256194 1.08 ENST00000216629.11
ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr9_-_112332962 1.05 ENST00000458258.5
ENST00000210227.4
PTBP3
polypyrimidine tract binding protein 3
chr6_+_44223770 1.05 ENST00000652453.1
ENST00000393841.6
ENST00000371724.6
ENST00000642777.1
ENST00000645692.1
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr1_+_207088825 1.04 ENST00000367078.8
C4BPB
complement component 4 binding protein beta
chr2_-_42361198 1.03 ENST00000234301.3
COX7A2L
cytochrome c oxidase subunit 7A2 like
chr7_-_142885737 1.00 ENST00000359396.9
ENST00000436401.1
TRPV6
transient receptor potential cation channel subfamily V member 6
chr6_-_53148822 0.98 ENST00000259803.8
GCM1
glial cells missing transcription factor 1
chr4_-_25030922 0.97 ENST00000382114.9
LGI2
leucine rich repeat LGI family member 2
chr6_-_52803807 0.93 ENST00000334575.6
GSTA1
glutathione S-transferase alpha 1
chr3_+_112332500 0.92 ENST00000606471.5
CD200
CD200 molecule
chr7_+_111091006 0.89 ENST00000451085.5
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chr3_-_9769910 0.89 ENST00000256460.8
CAMK1
calcium/calmodulin dependent protein kinase I
chrX_+_15749848 0.86 ENST00000479740.5
ENST00000454127.2
CA5B
carbonic anhydrase 5B
chr19_+_7920313 0.83 ENST00000221573.11
ENST00000595637.1
SNAPC2
small nuclear RNA activating complex polypeptide 2
chr10_+_101354028 0.80 ENST00000393441.8
BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
chr7_+_97005538 0.80 ENST00000518156.3
DLX6
distal-less homeobox 6
chr1_+_1281224 0.79 ENST00000400928.7
SCNN1D
sodium channel epithelial 1 subunit delta
chr11_+_2301987 0.77 ENST00000612299.4
ENST00000182290.9
TSPAN32
tetraspanin 32
chr10_+_101354083 0.73 ENST00000408038.6
ENST00000370187.8
BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
chr2_+_203867764 0.72 ENST00000648405.2
CTLA4
cytotoxic T-lymphocyte associated protein 4
chr20_-_1184981 0.71 ENST00000429036.2
TMEM74B
transmembrane protein 74B
chrX_+_150363258 0.67 ENST00000683696.1
MAMLD1
mastermind like domain containing 1
chr12_-_56360084 0.67 ENST00000314128.9
ENST00000557235.5
ENST00000651915.1
STAT2
signal transducer and activator of transcription 2
chrX_+_150363306 0.64 ENST00000370401.7
ENST00000432680.7
MAMLD1
mastermind like domain containing 1
chr16_+_67893244 0.63 ENST00000291041.6
ENST00000570631.5
PSKH1
protein serine kinase H1
chr17_-_10469558 0.62 ENST00000255381.2
MYH4
myosin heavy chain 4
chr18_+_58045642 0.61 ENST00000676223.1
ENST00000675147.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr1_+_27935110 0.61 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr22_-_23751080 0.60 ENST00000341976.5
ZNF70
zinc finger protein 70
chr16_+_90022600 0.59 ENST00000620723.4
ENST00000268699.9
GAS8
growth arrest specific 8
chr12_+_67648737 0.59 ENST00000344096.4
ENST00000393555.3
DYRK2
dual specificity tyrosine phosphorylation regulated kinase 2
chr1_+_27934980 0.59 ENST00000373894.8
SMPDL3B
sphingomyelin phosphodiesterase acid like 3B
chr3_+_124094696 0.58 ENST00000360013.7
ENST00000684186.1
ENST00000684276.1
KALRN
kalirin RhoGEF kinase
chr10_-_102451536 0.58 ENST00000625129.1
C10orf95
chromosome 10 open reading frame 95
chr15_-_78811415 0.58 ENST00000388820.5
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif 7
chr9_+_77177511 0.55 ENST00000360280.8
ENST00000645632.1
ENST00000643348.1
VPS13A
vacuolar protein sorting 13 homolog A
chr4_-_40629842 0.54 ENST00000295971.12
RBM47
RNA binding motif protein 47
chr22_+_24603147 0.54 ENST00000412658.5
ENST00000445029.5
ENST00000400382.6
ENST00000419133.5
ENST00000438643.6
ENST00000452551.5
ENST00000412898.5
ENST00000400380.5
ENST00000455483.5
ENST00000430289.5
GGT1
gamma-glutamyltransferase 1
chr19_+_12751672 0.49 ENST00000549706.5
BEST2
bestrophin 2
chr1_+_202122910 0.49 ENST00000682545.1
ENST00000367282.6
ENST00000682887.1
GPR37L1
G protein-coupled receptor 37 like 1
chr7_-_117323041 0.48 ENST00000491214.1
ENST00000265441.8
WNT2
Wnt family member 2
chr19_-_12933680 0.45 ENST00000593021.1
ENST00000314606.9
ENST00000587981.1
ENST00000423140.6
FARSA
phenylalanyl-tRNA synthetase subunit alpha
chr7_+_73827737 0.44 ENST00000435050.1
CLDN4
claudin 4
chr7_+_76510516 0.44 ENST00000257632.9
UPK3B
uroplakin 3B
chr2_-_207167220 0.43 ENST00000421199.5
ENST00000457962.5
KLF7
Kruppel like factor 7
chr1_+_11189347 0.41 ENST00000376819.4
ANGPTL7
angiopoietin like 7
chr1_-_205631962 0.41 ENST00000289703.8
ENST00000357992.9
ELK4
ETS transcription factor ELK4
chr8_+_2045037 0.41 ENST00000262113.9
MYOM2
myomesin 2
chr7_-_81770039 0.40 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
HGF
hepatocyte growth factor
chr5_-_41870416 0.39 ENST00000196371.10
OXCT1
3-oxoacid CoA-transferase 1
chr18_+_58045683 0.39 ENST00000592846.5
ENST00000675801.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr16_-_89490479 0.38 ENST00000642600.1
ENST00000301030.10
ANKRD11
ankyrin repeat domain 11
chr1_-_167914089 0.38 ENST00000476818.2
ENST00000367848.1
ENST00000367851.9
ENST00000545172.5
ADCY10
adenylate cyclase 10
chr2_+_203867943 0.37 ENST00000295854.10
ENST00000487393.1
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte associated protein 4
chr10_+_97584347 0.35 ENST00000370649.3
ENST00000370646.9
ENSG00000249967.1
HOGA1
novel protein
4-hydroxy-2-oxoglutarate aldolase 1
chr20_+_1135178 0.35 ENST00000435720.5
PSMF1
proteasome inhibitor subunit 1
chr3_+_46877705 0.35 ENST00000449590.6
PTH1R
parathyroid hormone 1 receptor
chr17_+_6444441 0.31 ENST00000250056.12
ENST00000571373.5
ENST00000570337.6
ENST00000572595.6
ENST00000572447.6
ENST00000576056.5
PIMREG
PICALM interacting mitotic regulator
chr20_+_1135217 0.31 ENST00000381898.5
PSMF1
proteasome inhibitor subunit 1
chr1_+_27392612 0.31 ENST00000374024.4
GPR3
G protein-coupled receptor 3
chr3_-_49093578 0.31 ENST00000424300.5
QRICH1
glutamine rich 1
chr19_+_4304588 0.29 ENST00000221856.11
FSD1
fibronectin type III and SPRY domain containing 1
chr1_-_51878799 0.29 ENST00000354831.11
ENST00000544028.5
NRDC
nardilysin convertase
chr11_+_118956289 0.28 ENST00000264031.3
UPK2
uroplakin 2
chr8_+_2045058 0.27 ENST00000523438.1
MYOM2
myomesin 2
chr17_-_42185452 0.27 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr7_-_81770122 0.26 ENST00000423064.7
HGF
hepatocyte growth factor
chr2_-_196926717 0.23 ENST00000409475.5
ENST00000374738.3
PGAP1
post-GPI attachment to proteins inositol deacylase 1
chr1_+_202122881 0.23 ENST00000683302.1
ENST00000683557.1
GPR37L1
G protein-coupled receptor 37 like 1
chr2_+_201132872 0.21 ENST00000470178.6
CFLAR
CASP8 and FADD like apoptosis regulator
chr3_+_148697784 0.19 ENST00000497524.5
ENST00000418473.7
ENST00000349243.8
ENST00000404754.2
AGTR1
angiotensin II receptor type 1
chr12_+_25958891 0.18 ENST00000381352.7
ENST00000535907.5
ENST00000405154.6
ENST00000615708.4
RASSF8
Ras association domain family member 8
chr21_+_33230073 0.17 ENST00000342101.7
ENST00000413881.5
ENST00000443073.5
IFNAR2
interferon alpha and beta receptor subunit 2
chr1_-_51878711 0.15 ENST00000352171.12
NRDC
nardilysin convertase
chr12_-_10802627 0.13 ENST00000240687.2
TAS2R7
taste 2 receptor member 7
chr11_-_26722051 0.10 ENST00000396005.8
SLC5A12
solute carrier family 5 member 12
chr10_+_50990864 0.10 ENST00000401604.8
PRKG1
protein kinase cGMP-dependent 1
chr6_-_36986122 0.08 ENST00000460219.2
ENST00000373627.10
ENST00000373616.9
MTCH1
mitochondrial carrier 1
chr6_+_6588708 0.08 ENST00000230568.5
LY86
lymphocyte antigen 86
chr13_-_60013178 0.07 ENST00000498416.2
ENST00000465066.5
DIAPH3
diaphanous related formin 3
chr19_+_12751789 0.05 ENST00000553030.6
BEST2
bestrophin 2
chr6_-_87095059 0.05 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
CGA
glycoprotein hormones, alpha polypeptide
chr12_-_68253502 0.02 ENST00000328087.6
ENST00000538666.6
IL22
interleukin 22
chr2_+_227813834 0.01 ENST00000358813.5
ENST00000409189.7
CCL20
C-C motif chemokine ligand 20

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 9.0 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
1.2 3.6 GO:0016487 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.7 2.9 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.6 2.5 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.6 4.8 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.5 1.4 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.4 2.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.4 3.6 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.4 8.3 GO:0006068 ethanol catabolic process(GO:0006068)
0.3 1.0 GO:0060018 astrocyte fate commitment(GO:0060018)
0.3 2.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.3 3.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.3 1.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.3 1.9 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.2 2.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 4.5 GO:0015671 oxygen transport(GO:0015671)
0.2 1.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.2 2.2 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.2 1.1 GO:0015862 uridine transport(GO:0015862)
0.2 1.8 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.2 0.9 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.2 1.4 GO:0019732 antifungal humoral response(GO:0019732)
0.2 3.0 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.1 1.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 3.0 GO:0097503 glycosphingolipid biosynthetic process(GO:0006688) sialylation(GO:0097503)
0.1 0.6 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.7 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 7.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 0.4 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.1 1.2 GO:0051967 regulation of short-term neuronal synaptic plasticity(GO:0048172) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 1.4 GO:0015884 folic acid transport(GO:0015884)
0.1 1.0 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.7 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.1 0.5 GO:0003228 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009) foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.1 0.5 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.1 0.4 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.6 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 1.0 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.5 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 4.3 GO:0007032 endosome organization(GO:0007032)
0.1 2.7 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.1 1.3 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.1 6.9 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 3.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.4 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 1.5 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.2 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 2.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.1 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.4 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 5.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.9 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.7 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.3 GO:0002076 osteoblast development(GO:0002076)
0.0 0.3 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 1.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.4 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.6 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 2.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.3 4.5 GO:0005833 hemoglobin complex(GO:0005833)
0.2 1.4 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 1.5 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.2 0.5 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 1.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 2.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 3.5 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 1.3 GO:0032982 myosin filament(GO:0032982)
0.0 2.4 GO:0043198 dendritic shaft(GO:0043198)
0.0 4.8 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 5.2 GO:0005604 basement membrane(GO:0005604)
0.0 5.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 7.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.5 GO:1990909 Wnt signalosome(GO:1990909)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.7 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.0 GO:0005771 multivesicular body(GO:0005771)
0.0 1.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 5.6 GO:0060076 excitatory synapse(GO:0060076)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.0 GO:0031696 alpha-2C adrenergic receptor binding(GO:0031696)
1.4 8.3 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
1.3 6.5 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.7 3.0 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
0.7 2.2 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.7 4.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 2.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.5 1.9 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.4 3.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.3 1.3 GO:0004461 lactose synthase activity(GO:0004461)
0.3 2.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 4.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 1.4 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 6.8 GO:0002162 dystroglycan binding(GO:0002162)
0.3 3.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 0.7 GO:0036505 prosaposin receptor activity(GO:0036505)
0.2 6.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 2.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 1.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 1.4 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 1.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 2.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.4 GO:0008410 CoA-transferase activity(GO:0008410)
0.1 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.4 GO:0005542 folic acid binding(GO:0005542)
0.1 0.3 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 0.4 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 1.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.8 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 1.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.5 GO:0019894 kinesin binding(GO:0019894)
0.0 1.5 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.5 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.7 GO:0042056 chemoattractant activity(GO:0042056)
0.0 2.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0004905 type I interferon receptor activity(GO:0004905)
0.0 0.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.6 GO:0030145 manganese ion binding(GO:0030145)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.1 PID LKB1 PATHWAY LKB1 signaling events
0.1 4.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.8 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 2.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.4 PID AURORA A PATHWAY Aurora A signaling
0.0 1.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.6 PID E2F PATHWAY E2F transcription factor network
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 4.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 4.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 3.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 3.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 3.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 6.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.1 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 1.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport