Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for HDX

Z-value: 1.09

Motif logo

logo of

Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.14 HDX

Activity profile of HDX motif

Sorted Z-values of HDX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_142800957 8.03 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr1_-_169711603 6.01 ENST00000236147.6
ENST00000650983.1
SELL
selectin L
chr1_-_153390976 5.98 ENST00000368732.5
ENST00000368733.4
S100A8
S100 calcium binding protein A8
chr1_+_84164370 3.21 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr2_-_112836702 2.52 ENST00000416750.1
ENST00000263341.7
ENST00000418817.5
IL1B
interleukin 1 beta
chr12_+_10307950 2.40 ENST00000543420.5
ENST00000543777.5
KLRD1
killer cell lectin like receptor D1
chr12_+_10307818 1.98 ENST00000350274.9
ENST00000336164.9
KLRD1
killer cell lectin like receptor D1
chr12_-_118359639 1.62 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr3_-_51499950 1.43 ENST00000423656.5
ENST00000504652.5
ENST00000684031.1
DCAF1
DDB1 and CUL4 associated factor 1
chr5_-_35230332 1.19 ENST00000504500.5
PRLR
prolactin receptor
chr22_+_40044802 0.90 ENST00000441751.5
ENST00000301923.13
TNRC6B
trinucleotide repeat containing adaptor 6B
chr18_+_31447732 0.88 ENST00000257189.5
DSG3
desmoglein 3
chr2_+_169069537 0.68 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
DHRS9
dehydrogenase/reductase 9
chr9_+_6215786 0.56 ENST00000417746.6
ENST00000682010.1
IL33
interleukin 33
chr14_+_79279906 0.56 ENST00000428277.6
NRXN3
neurexin 3
chr2_-_191020960 0.51 ENST00000432058.1
STAT1
signal transducer and activator of transcription 1
chr1_+_62597510 0.50 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr7_-_135728177 0.47 ENST00000682651.1
ENST00000354042.8
SLC13A4
solute carrier family 13 member 4
chr5_-_35230467 0.40 ENST00000515839.1
ENST00000618457.5
PRLR
prolactin receptor
chr3_-_165837412 0.39 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
BCHE
butyrylcholinesterase
chr5_-_135954962 0.39 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
LECT2
leukocyte cell derived chemotaxin 2
chr3_+_54123452 0.38 ENST00000620722.4
ENST00000490478.5
CACNA2D3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr12_+_56763316 0.32 ENST00000322165.1
HSD17B6
hydroxysteroid 17-beta dehydrogenase 6
chr8_+_24294044 0.30 ENST00000265769.9
ADAM28
ADAM metallopeptidase domain 28
chr14_+_79279339 0.29 ENST00000557594.5
NRXN3
neurexin 3
chr6_+_32969345 0.28 ENST00000678250.1
BRD2
bromodomain containing 2
chr7_+_129368123 0.26 ENST00000460109.5
ENST00000474594.5
AHCYL2
adenosylhomocysteinase like 2
chr14_+_79279403 0.25 ENST00000281127.11
NRXN3
neurexin 3
chr11_+_9664061 0.23 ENST00000447399.6
ENST00000318950.11
SWAP70
switching B cell complex subunit SWAP70
chr1_-_110519175 0.20 ENST00000369771.4
KCNA10
potassium voltage-gated channel subfamily A member 10
chr9_+_35538619 0.07 ENST00000455600.1
RUSC2
RUN and SH3 domain containing 2
chr3_+_107522936 0.04 ENST00000415149.6
ENST00000402543.5
ENST00000325805.13
ENST00000427402.5
BBX
BBX high mobility group box domain containing
chr14_+_79279681 0.02 ENST00000679122.1
NRXN3
neurexin 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.6 6.0 GO:0032119 sequestering of zinc ion(GO:0032119)
0.5 3.2 GO:0097338 response to clozapine(GO:0097338)
0.3 1.6 GO:0038161 prolactin signaling pathway(GO:0038161)
0.3 1.4 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.2 0.5 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.1 6.0 GO:0033198 response to ATP(GO:0033198)
0.1 0.4 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 8.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.6 GO:0061518 microglial cell activation involved in immune response(GO:0002282) macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518)
0.1 0.7 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.2 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 1.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.9 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 0.5 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.1 0.3 GO:0006710 androgen catabolic process(GO:0006710)
0.1 4.4 GO:0002228 natural killer cell mediated immunity(GO:0002228)
0.0 0.5 GO:0008272 sulfate transport(GO:0008272)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 1.1 GO:0090129 positive regulation of synapse maturation(GO:0090129)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 8.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.9 GO:0030057 desmosome(GO:0030057)
0.0 10.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 6.0 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.6 GO:0031904 endosome lumen(GO:0031904)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.2 6.0 GO:0043208 glycosphingolipid binding(GO:0043208)
0.9 4.4 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.4 1.6 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 3.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 1.4 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 8.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 2.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 1.0 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 0.5 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 1.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.5 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 6.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 3.2 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.6 PID ERBB4 PATHWAY ErbB4 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.2 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 1.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 2.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.9 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin