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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HINFP1

Z-value: 4.10

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Transcription factors associated with HINFP1

Gene Symbol Gene ID Gene Info

Activity profile of HINFP1 motif

Sorted Z-values of HINFP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HINFP1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_+_12308232 15.20 ENST00000590103.5
ENST00000591909.5
ENST00000586653.5
ENST00000317702.10
ENST00000592683.5
ENST00000590967.5
ENST00000591208.1
ENST00000591463.1
TUBB6
tubulin beta 6 class V
chr2_-_233854566 15.11 ENST00000432087.5
ENST00000441687.5
ENST00000414924.5
HJURP
Holliday junction recognition protein
chr5_+_155013755 13.38 ENST00000435029.6
KIF4B
kinesin family member 4B
chr2_-_233854506 11.97 ENST00000411486.7
HJURP
Holliday junction recognition protein
chr2_+_130182224 10.13 ENST00000651060.1
ENST00000409255.1
ENST00000281871.11
ENST00000455239.1
MZT2B
mitotic spindle organizing protein 2B
chr18_+_11981488 9.82 ENST00000269159.8
IMPA2
inositol monophosphatase 2
chr7_-_32495238 7.08 ENST00000409952.3
ENST00000409909.7
LSM5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr3_+_133574434 6.57 ENST00000508481.5
ENST00000420115.6
ENST00000504867.5
ENST00000507408.5
ENST00000511392.5
ENST00000515421.1
CDV3
CDV3 homolog
chr18_+_11981548 5.79 ENST00000588927.5
IMPA2
inositol monophosphatase 2
chr2_-_130181542 5.63 ENST00000441135.1
ENST00000680679.1
ENST00000680401.1
ENST00000351288.10
ENST00000680298.1
ENST00000431183.6
SMPD4
sphingomyelin phosphodiesterase 4
chr3_+_133573915 5.61 ENST00000431519.6
CDV3
CDV3 homolog
chr6_-_144095556 5.55 ENST00000367569.4
SF3B5
splicing factor 3b subunit 5
chr3_+_133574007 5.36 ENST00000503932.5
CDV3
CDV3 homolog
chr1_+_42456525 4.75 ENST00000372560.3
ENST00000372561.4
ENST00000372556.3
PPCS
phosphopantothenoylcysteine synthetase
chr1_+_147928420 4.44 ENST00000314163.12
ENST00000468618.6
GPR89B
G protein-coupled receptor 89B
chr2_+_130181662 4.40 ENST00000425361.5
ENST00000457492.5
MZT2B
mitotic spindle organizing protein 2B
chr1_+_42456090 4.31 ENST00000372562.1
PPCS
phosphopantothenoylcysteine synthetase
chr10_-_95693893 4.15 ENST00000371209.5
ENST00000680144.1
ENST00000430368.6
ENST00000371217.10
TCTN3
tectonic family member 3
chr12_+_19129779 3.98 ENST00000539256.5
ENST00000299275.10
ENST00000538714.5
PLEKHA5
pleckstrin homology domain containing A5
chr12_+_19129689 3.81 ENST00000429027.7
ENST00000540972.5
PLEKHA5
pleckstrin homology domain containing A5
chr21_+_34073569 3.10 ENST00000399312.3
ENST00000381151.5
ENST00000362077.4
MRPS6
SLC5A3
ENSG00000272657.1
mitochondrial ribosomal protein S6
solute carrier family 5 member 3
novel transcript
chr9_-_91423819 2.86 ENST00000297689.4
NFIL3
nuclear factor, interleukin 3 regulated
chr3_+_138608700 2.68 ENST00000360570.7
FAIM
Fas apoptotic inhibitory molecule
chr10_-_95693936 2.60 ENST00000680709.1
ENST00000680353.1
ENST00000679566.1
ENST00000614499.5
TCTN3
tectonic family member 3
chr9_-_109498251 2.56 ENST00000374541.4
ENST00000262539.7
PTPN3
protein tyrosine phosphatase non-receptor type 3
chr6_-_56843638 2.38 ENST00000421834.6
ENST00000370788.6
DST
dystonin
chr11_+_95066913 2.10 ENST00000587424.3
SRSF8
serine and arginine rich splicing factor 8
chr12_-_120265719 2.04 ENST00000637617.2
ENST00000267257.11
ENST00000228307.11
ENST00000424649.6
PXN
paxillin
chr9_-_83980578 1.84 ENST00000376281.8
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr15_+_84981834 1.57 ENST00000394553.6
PDE8A
phosphodiesterase 8A
chr1_-_42766978 0.53 ENST00000372526.2
ENST00000236040.8
ENST00000296388.10
ENST00000397054.7
P3H1
prolyl 3-hydroxylase 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 15.6 GO:0006021 inositol biosynthetic process(GO:0006021)
1.0 3.1 GO:0015798 myo-inositol transport(GO:0015798)
0.8 13.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.8 27.1 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.5 5.6 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.5 1.8 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.3 9.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.3 2.6 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902)
0.2 2.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.5 GO:1901874 negative regulation of post-translational protein modification(GO:1901874)
0.2 7.1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 4.4 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 1.7 GO:0007172 signal complex assembly(GO:0007172)
0.1 2.9 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 6.7 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 15.2 GO:0007017 microtubule-based process(GO:0007017)
0.0 7.8 GO:0061458 reproductive system development(GO:0061458)
0.0 7.7 GO:0008380 RNA splicing(GO:0008380)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 14.5 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
1.0 7.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.4 2.2 GO:0031673 H zone(GO:0031673)
0.3 5.5 GO:0005686 U2 snRNP(GO:0005686)
0.2 13.4 GO:0005871 kinesin complex(GO:0005871)
0.2 27.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 3.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 6.7 GO:0060170 ciliary membrane(GO:0060170)
0.1 2.0 GO:0005875 microtubule associated complex(GO:0005875)
0.0 4.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 15.2 GO:0005874 microtubule(GO:0005874)
0.0 1.5 GO:0002102 podosome(GO:0002102)
0.0 5.6 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.9 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.6 7.8 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.6 5.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.5 13.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.4 3.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.3 9.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 4.4 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.1 0.5 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1 27.1 GO:0042393 histone binding(GO:0042393)
0.1 2.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.0 GO:0017166 vinculin binding(GO:0017166)
0.1 13.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 2.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.8 GO:0003697 single-stranded DNA binding(GO:0003697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 27.1 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 9.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.5 15.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.5 13.4 REACTOME KINESINS Genes involved in Kinesins
0.4 7.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 5.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 5.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 3.1 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 1.8 REACTOME MRNA SPLICING Genes involved in mRNA Splicing