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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HNF1A_HNF1B

Z-value: 3.05

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
ENSG00000135100.19 HNF1A
ENSG00000275410.6 HNF1B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg38_v1_chr12_+_120978686_1209787490.529.9e-17Click!
HNF1Bhg38_v1_chr17_-_37745018_377450690.413.8e-10Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_66229380 61.70 ENST00000205948.11
apolipoprotein H
chr4_-_71784046 60.20 ENST00000513476.5
ENST00000273951.13
GC vitamin D binding protein
chr4_+_73436198 50.59 ENST00000395792.7
alpha fetoprotein
chr4_+_73436244 50.18 ENST00000226359.2
alpha fetoprotein
chr6_+_160702238 41.49 ENST00000366924.6
ENST00000308192.14
ENST00000418964.1
plasminogen
chr4_+_154563003 39.31 ENST00000302068.9
ENST00000509493.1
fibrinogen beta chain
chr19_-_35812838 36.87 ENST00000653904.2
proline dehydrogenase 2
chr14_-_94388589 35.71 ENST00000402629.1
ENST00000556091.1
ENST00000393087.9
ENST00000554720.1
serpin family A member 1
chr4_-_154590735 34.86 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
fibrinogen alpha chain
chr4_+_73404255 33.24 ENST00000621628.4
ENST00000621085.4
ENST00000415165.6
ENST00000295897.9
ENST00000503124.5
ENST00000509063.5
ENST00000401494.7
albumin
chr2_+_233760265 32.96 ENST00000305208.10
ENST00000360418.4
UDP glucuronosyltransferase family 1 member A1
chr2_+_233692881 32.06 ENST00000305139.11
UDP glucuronosyltransferase family 1 member A6
chr4_+_73481737 31.88 ENST00000226355.5
afamin
chr9_-_121050264 28.47 ENST00000223642.3
complement C5
chr15_+_58431985 28.13 ENST00000433326.2
ENST00000299022.10
lipase C, hepatic type
chr7_-_50565381 27.92 ENST00000444124.7
dopa decarboxylase
chr16_-_20576277 27.41 ENST00000566384.5
ENST00000565232.5
ENST00000567001.5
ENST00000565322.5
ENST00000569344.5
ENST00000329697.10
ENST00000568882.1
acyl-CoA synthetase medium chain family member 2B
chr1_+_207104226 22.40 ENST00000367070.8
complement component 4 binding protein alpha
chr19_+_49513353 22.03 ENST00000596975.5
Fc fragment of IgG receptor and transporter
chr6_-_160664270 20.74 ENST00000316300.10
lipoprotein(a)
chr7_+_45888360 20.70 ENST00000457280.5
insulin like growth factor binding protein 1
chr16_+_20451461 20.55 ENST00000574251.5
ENST00000573854.6
acyl-CoA synthetase medium chain family member 2A
chr8_-_17895487 20.46 ENST00000427924.5
ENST00000381841.4
fibrinogen like 1
chr2_-_88128049 20.17 ENST00000393750.3
ENST00000295834.8
fatty acid binding protein 1
chr16_+_20451596 19.93 ENST00000575690.5
ENST00000571894.1
acyl-CoA synthetase medium chain family member 2A
chr16_+_20451563 19.55 ENST00000417235.6
ENST00000219054.10
acyl-CoA synthetase medium chain family member 2A
chr14_-_94293071 19.47 ENST00000554723.5
serpin family A member 10
chr14_-_94293024 19.44 ENST00000393096.5
serpin family A member 10
chr2_+_233729042 19.38 ENST00000482026.6
UDP glucuronosyltransferase family 1 member A3
chr19_+_49513154 18.48 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
Fc fragment of IgG receptor and transporter
chr7_+_45888479 18.24 ENST00000275525.8
ENST00000468955.1
insulin like growth factor binding protein 1
chr10_+_113553039 17.88 ENST00000351270.4
hyaluronan binding protein 2
chr5_+_177086867 17.71 ENST00000503708.5
ENST00000393648.6
ENST00000514472.1
ENST00000502906.5
ENST00000292408.9
ENST00000510911.5
fibroblast growth factor receptor 4
chr14_-_94293260 17.70 ENST00000261994.9
serpin family A member 10
chr6_+_31655888 17.55 ENST00000375916.4
apolipoprotein M
chr2_+_87748087 17.20 ENST00000359481.9
plasminogen like B2
chr3_+_186666003 16.73 ENST00000232003.5
histidine rich glycoprotein
chr4_+_3441960 16.06 ENST00000382774.8
ENST00000511533.1
HGF activator
chr14_+_94561435 15.69 ENST00000557004.6
ENST00000555095.5
ENST00000298841.5
ENST00000554220.5
ENST00000553780.5
serpin family A member 4
serpin family A member 5
chr14_-_57493827 15.47 ENST00000526336.1
ENST00000216445.8
coiled-coil domain containing 198
chr6_-_25930611 15.03 ENST00000360488.7
solute carrier family 17 member 2
chr19_+_11239602 14.95 ENST00000252453.12
angiopoietin like 8
chr14_+_20688756 14.83 ENST00000397990.5
ENST00000555597.1
angiogenin
ribonuclease A family member 4
chr17_+_42900791 14.70 ENST00000592383.5
ENST00000253801.7
ENST00000585489.1
glucose-6-phosphatase catalytic subunit 1
chr6_-_25930678 14.24 ENST00000377850.8
solute carrier family 17 member 2
chr11_+_64555684 14.08 ENST00000377585.7
solute carrier family 22 member 11
chr17_+_1742836 13.85 ENST00000324015.7
ENST00000450523.6
ENST00000453723.5
ENST00000453066.6
ENST00000382061.5
serpin family F member 2
chr20_+_43558968 13.31 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
serum/glucocorticoid regulated kinase 2
chr2_-_87021844 13.26 ENST00000355705.4
ENST00000409310.6
plasminogen like B1
chr10_+_133527355 13.20 ENST00000252945.8
ENST00000421586.5
ENST00000418356.1
cytochrome P450 family 2 subfamily E member 1
chr11_-_117824734 13.10 ENST00000292079.7
FXYD domain containing ion transport regulator 2
chr12_-_91180365 13.10 ENST00000547937.5
decorin
chr7_-_44541318 13.07 ENST00000381160.8
NPC1 like intracellular cholesterol transporter 1
chr2_+_233617626 12.83 ENST00000373450.5
UDP glucuronosyltransferase family 1 member A8
chr12_-_91153149 12.60 ENST00000550758.1
decorin
chr4_-_99290975 12.57 ENST00000209668.3
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr11_+_46719193 12.05 ENST00000311907.10
ENST00000530231.5
ENST00000442468.1
coagulation factor II, thrombin
chr11_+_114296347 11.78 ENST00000299964.4
nicotinamide N-methyltransferase
chr11_+_64555924 11.55 ENST00000301891.9
solute carrier family 22 member 11
chr6_-_52763473 11.54 ENST00000493422.3
glutathione S-transferase alpha 2
chr1_+_17580474 11.51 ENST00000375415.5
Rho guanine nucleotide exchange factor 10 like
chrX_-_106038721 11.49 ENST00000372563.2
serpin family A member 7
chr7_-_44541262 11.30 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1 like intracellular cholesterol transporter 1
chr1_+_103750406 11.26 ENST00000370079.3
amylase alpha 1C
chr4_-_99352754 10.68 ENST00000639454.1
alcohol dehydrogenase 1B (class I), beta polypeptide
chr2_+_233718734 10.49 ENST00000373409.8
UDP glucuronosyltransferase family 1 member A4
chr20_+_44355692 10.12 ENST00000316673.8
ENST00000609795.5
ENST00000457232.5
ENST00000609262.5
hepatocyte nuclear factor 4 alpha
chr16_+_20764036 10.07 ENST00000440284.6
acyl-CoA synthetase medium chain family member 3
chr16_-_66918839 10.01 ENST00000565235.2
ENST00000568632.5
ENST00000565796.5
cadherin 16
chr22_-_30574572 10.01 ENST00000402369.5
galactose-3-O-sulfotransferase 1
chr16_-_66918876 9.94 ENST00000570262.5
ENST00000299752.9
ENST00000394055.7
cadherin 16
chr8_-_69833338 9.92 ENST00000524945.5
solute carrier organic anion transporter family member 5A1
chr21_-_46155567 9.89 ENST00000291670.9
ENST00000397748.5
ENST00000397743.1
ENST00000397746.8
formimidoyltransferase cyclodeaminase
chr10_+_99782628 8.56 ENST00000648689.1
ENST00000647814.1
ATP binding cassette subfamily C member 2
chr16_+_20763990 8.33 ENST00000289416.10
acyl-CoA synthetase medium chain family member 3
chr20_-_7940444 8.25 ENST00000378789.4
hydroxyacid oxidase 1
chr4_+_99574812 8.09 ENST00000422897.6
ENST00000265517.10
microsomal triglyceride transfer protein
chr10_-_50885619 8.04 ENST00000373997.8
APOBEC1 complementation factor
chr10_-_50885656 7.91 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
APOBEC1 complementation factor
chr2_+_233712905 7.78 ENST00000373414.4
UDP glucuronosyltransferase family 1 member A5
chr6_+_25754699 7.55 ENST00000439485.6
ENST00000377905.9
solute carrier family 17 member 4
chr17_-_352784 7.47 ENST00000577079.5
ENST00000331302.12
ENST00000618002.4
ENST00000536489.6
rabphilin 3A like (without C2 domains)
chr2_-_227379297 7.44 ENST00000304568.4
transmembrane 4 L six family member 20
chr8_-_94208548 7.33 ENST00000027335.8
ENST00000441892.6
ENST00000521491.1
cadherin 17
chr1_+_119368773 7.17 ENST00000457318.5
ENST00000622548.4
ENST00000325945.4
hydroxyacid oxidase 2
chr6_+_131250375 6.95 ENST00000474850.2
A-kinase anchoring protein 7
chr4_-_68670648 6.92 ENST00000338206.6
UDP glucuronosyltransferase family 2 member B15
chr4_-_99352730 6.75 ENST00000510055.5
ENST00000515683.6
ENST00000511397.3
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr5_+_176549323 6.70 ENST00000261944.9
cadherin related family member 2
chr17_+_28473278 6.65 ENST00000444914.7
solute carrier family 13 member 2
chr7_+_141995872 6.65 ENST00000497673.5
ENST00000620571.1
ENST00000475668.6
maltase-glucoamylase
chr4_-_1173168 6.61 ENST00000514490.5
ENST00000431380.5
ENST00000503765.5
spondin 2
chr12_-_102480638 6.38 ENST00000392904.5
insulin like growth factor 1
chr1_-_19815270 6.22 ENST00000375121.4
ring finger protein 186
chr1_+_62597510 6.09 ENST00000371129.4
angiopoietin like 3
chr4_-_109801978 5.92 ENST00000510800.1
ENST00000512148.5
ENST00000394634.7
ENST00000394635.8
ENST00000645635.1
complement factor I
novel protein
chr21_+_38256698 5.90 ENST00000613499.4
ENST00000612702.4
ENST00000398925.5
ENST00000398928.5
ENST00000328656.8
ENST00000443341.5
potassium inwardly rectifying channel subfamily J member 15
chr6_-_25874212 5.86 ENST00000361703.10
ENST00000397060.8
solute carrier family 17 member 3
chr7_+_141995826 5.81 ENST00000549489.6
maltase-glucoamylase
chr15_+_48206286 5.78 ENST00000396577.7
ENST00000380993.8
solute carrier family 12 member 1
chr9_-_91950201 5.72 ENST00000375708.4
receptor tyrosine kinase like orphan receptor 2
chr1_+_56854764 5.71 ENST00000361249.4
complement C8 alpha chain
chr20_+_44401397 5.68 ENST00000682427.1
ENST00000681977.1
ENST00000684136.1
ENST00000684046.1
ENST00000684476.1
ENST00000619550.5
ENST00000682169.1
hepatocyte nuclear factor 4 alpha
chrX_-_15601077 5.67 ENST00000680121.1
angiotensin I converting enzyme 2
chr13_+_33016415 5.45 ENST00000380099.4
klotho
chr12_-_102480604 5.32 ENST00000392905.7
insulin like growth factor 1
chr17_+_28473635 5.30 ENST00000314669.10
ENST00000545060.2
solute carrier family 13 member 2
chr2_-_162074394 5.29 ENST00000676810.1
dipeptidyl peptidase 4
chr12_+_100473916 5.28 ENST00000549996.5
nuclear receptor subfamily 1 group H member 4
chr12_-_102480552 5.26 ENST00000337514.11
ENST00000307046.8
insulin like growth factor 1
chr12_+_100503352 5.19 ENST00000551379.5
ENST00000188403.7
nuclear receptor subfamily 1 group H member 4
chr19_+_1205761 5.15 ENST00000326873.12
ENST00000586243.5
serine/threonine kinase 11
chr6_+_167291329 5.00 ENST00000366829.2
unc-93 homolog A
chr19_+_41797147 4.99 ENST00000596544.1
CEA cell adhesion molecule 3
chr21_+_38256984 4.85 ENST00000398938.7
potassium inwardly rectifying channel subfamily J member 15
chr14_+_64704380 4.84 ENST00000247226.13
ENST00000394691.7
pleckstrin homology and RhoGEF domain containing G3
chr2_-_162074182 4.71 ENST00000360534.8
dipeptidyl peptidase 4
chr16_+_89630263 4.66 ENST00000261615.5
dipeptidase 1
chrX_-_15600953 4.66 ENST00000679212.1
ENST00000679278.1
ENST00000678046.1
ENST00000252519.8
angiotensin I converting enzyme 2
chr2_-_162074050 4.62 ENST00000676768.1
dipeptidyl peptidase 4
chr8_-_86743626 4.56 ENST00000320005.6
cyclic nucleotide gated channel subunit beta 3
chr7_-_27180230 4.55 ENST00000396344.4
homeobox A10
chr12_+_100473951 4.35 ENST00000648861.1
ENST00000546380.1
nuclear receptor subfamily 1 group H member 4
chr14_-_64942720 4.27 ENST00000557049.1
ENST00000389614.6
glutathione peroxidase 2
chr3_-_138174879 4.24 ENST00000260803.9
debranching RNA lariats 1
chr6_-_116060859 4.17 ENST00000606080.2
fyn related Src family tyrosine kinase
chr22_+_44702186 4.14 ENST00000336985.11
ENST00000403696.5
ENST00000457960.5
ENST00000361473.9
proline rich 5
PRR5-ARHGAP8 readthrough
chr4_+_186266183 4.11 ENST00000403665.7
ENST00000492972.6
ENST00000264692.8
coagulation factor XI
chr2_+_27496830 4.09 ENST00000264717.7
glucokinase regulator
chr6_+_31739948 4.05 ENST00000375755.8
ENST00000425703.5
ENST00000375750.9
ENST00000375703.7
ENST00000375740.7
mutS homolog 5
chr12_+_21131187 3.96 ENST00000256958.3
solute carrier organic anion transporter family member 1B1
chr14_-_64942783 3.92 ENST00000612794.1
glutathione peroxidase 2
chr14_+_39233908 3.91 ENST00000280082.4
MIA SH3 domain ER export factor 2
chr8_+_22053543 3.86 ENST00000519850.5
ENST00000381470.7
dematin actin binding protein
chrX_+_16650155 3.84 ENST00000380200.3
S100 calcium binding protein G
chr1_+_103617427 3.83 ENST00000423678.2
ENST00000414303.7
amylase alpha 2A
chr17_+_70075317 3.75 ENST00000589377.1
potassium inwardly rectifying channel subfamily J member 16
chr7_-_150323489 3.75 ENST00000683684.1
ENST00000478393.5
actin related protein 3C
chr12_-_110920568 3.71 ENST00000548438.1
ENST00000228841.15
myosin light chain 2
chr8_-_123737378 3.60 ENST00000419625.6
ENST00000262219.10
annexin A13
chr12_-_18090141 3.60 ENST00000536890.1
RERG like
chr22_-_21982748 3.57 ENST00000398793.6
ENST00000437929.5
ENST00000456075.5
ENST00000434517.1
ENST00000424393.5
ENST00000357179.10
ENST00000449704.5
ENST00000437103.1
DNA topoisomerase III beta
chr6_+_125749623 3.50 ENST00000368364.4
hes related family bHLH transcription factor with YRPW motif 2
chr19_+_41796616 3.43 ENST00000344550.4
CEA cell adhesion molecule 3
chr13_-_103066411 3.43 ENST00000245312.5
solute carrier family 10 member 2
chr22_+_30607072 3.41 ENST00000450638.5
transcobalamin 2
chr12_+_100473708 3.41 ENST00000548884.5
ENST00000392986.8
nuclear receptor subfamily 1 group H member 4
chr19_+_41796580 3.40 ENST00000357396.8
ENST00000630848.2
CEA cell adhesion molecule 3
chr6_-_29045175 3.37 ENST00000377175.2
olfactory receptor family 2 subfamily W member 1
chr10_-_70888546 3.31 ENST00000299299.4
pterin-4 alpha-carbinolamine dehydratase 1
chr22_+_30607145 3.24 ENST00000405742.7
transcobalamin 2
chr13_+_95433593 3.23 ENST00000376873.7
claudin 10
chr22_+_30607167 3.21 ENST00000215838.8
transcobalamin 2
chr17_+_70075215 3.20 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
potassium inwardly rectifying channel subfamily J member 16
chr2_-_74328166 3.18 ENST00000358683.8
solute carrier family 4 member 5
chr15_+_58138368 3.16 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr9_+_100099233 3.08 ENST00000262457.7
ENST00000262456.6
ENST00000374921.3
inversin
chr7_+_130486171 2.97 ENST00000341441.9
ENST00000416162.7
mesoderm specific transcript
chr1_-_207032749 2.88 ENST00000359470.6
ENST00000461135.2
chromosome 1 open reading frame 116
chr12_-_18090185 2.73 ENST00000229002.6
ENST00000538724.6
RERG like
chr4_-_69653223 2.72 ENST00000286604.8
ENST00000505512.1
ENST00000514019.1
UDP glucuronosyltransferase family 2 member A1 complex locus
chr7_+_130486324 2.69 ENST00000427521.6
ENST00000378576.9
mesoderm specific transcript
chr12_+_18242955 2.65 ENST00000676171.1
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr6_+_167291309 2.64 ENST00000230256.8
unc-93 homolog A
chr5_+_132369691 2.60 ENST00000245407.8
solute carrier family 22 member 5
chr1_+_207088825 2.56 ENST00000367078.8
complement component 4 binding protein beta
chr14_+_24120956 2.53 ENST00000558325.2
novel protein
chr1_+_207089283 2.50 ENST00000391923.1
complement component 4 binding protein beta
chr6_-_117425905 2.49 ENST00000368507.8
ROS proto-oncogene 1, receptor tyrosine kinase
chr6_+_106086316 2.49 ENST00000369091.6
ENST00000369096.9
PR/SET domain 1
chr6_-_117425855 2.38 ENST00000368508.7
ROS proto-oncogene 1, receptor tyrosine kinase
chr16_-_87936529 2.36 ENST00000649794.3
ENST00000649158.1
ENST00000648177.1
carbonic anhydrase 5A
chr19_-_41627051 2.25 ENST00000221954.6
ENST00000600925.1
CEA cell adhesion molecule 4
chr4_+_119135825 2.19 ENST00000307128.6
myozenin 2
chr4_+_168092530 2.09 ENST00000359299.8
annexin A10
chr12_+_25052732 2.08 ENST00000547044.5
inositol 1,4,5-triphosphate receptor associated 2
chr6_+_167122742 1.97 ENST00000341935.9
ENST00000349984.6
C-C motif chemokine receptor 6
chr7_-_123199960 1.89 ENST00000194130.7
solute carrier family 13 member 1
chr1_+_207089233 1.87 ENST00000243611.9
ENST00000367076.7
complement component 4 binding protein beta
chr15_-_55408018 1.84 ENST00000569205.5
cell cycle progression 1
chr12_-_8540873 1.77 ENST00000545274.5
ENST00000446457.6
ENST00000299663.8
C-type lectin domain family 4 member E
chr11_+_560956 1.68 ENST00000397582.7
ENST00000397583.8
Ras association domain family member 7
chr3_+_38265802 1.65 ENST00000311856.9
solute carrier family 22 member 13
chr12_+_20810698 1.58 ENST00000540853.5
ENST00000381545.8
solute carrier organic anion transporter family member 1B3
chr10_-_37857582 1.47 ENST00000395867.8
ENST00000611278.4
zinc finger protein 248
chr5_-_35195236 1.35 ENST00000509839.5
prolactin receptor
chr15_+_85380565 1.34 ENST00000559362.5
ENST00000394518.7
A-kinase anchoring protein 13
chrX_+_1591590 1.31 ENST00000313871.9
ENST00000381261.8
A-kinase anchoring protein 17A
chr8_-_107498041 1.25 ENST00000297450.7
angiopoietin 1
chr4_-_993430 1.24 ENST00000361661.6
ENST00000622731.4
solute carrier family 26 member 1
chr22_+_32043253 1.20 ENST00000266088.9
solute carrier family 5 member 1
chr20_+_44401222 1.12 ENST00000316099.9
hepatocyte nuclear factor 4 alpha
chr1_-_197067234 1.09 ENST00000367412.2
coagulation factor XIII B chain
chr7_-_115968302 1.05 ENST00000457268.5
transcription factor EC
chr10_-_99930893 1.05 ENST00000636706.1
dynamin binding protein
chr11_-_83682385 1.04 ENST00000426717.6
discs large MAGUK scaffold protein 2
chr8_-_107497909 0.98 ENST00000517746.6
angiopoietin 1
chr3_-_192727500 0.97 ENST00000430714.5
ENST00000418610.1
ENST00000445105.7
ENST00000684728.1
ENST00000448795.5
ENST00000683935.1
ENST00000684282.1
ENST00000683451.1
fibroblast growth factor 12
chr1_-_113887574 0.92 ENST00000393316.8
BCL2 like 15
chr11_-_83682414 0.91 ENST00000404783.7
discs large MAGUK scaffold protein 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.6 145.8 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
13.5 40.5 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
12.3 36.9 GO:0010133 proline catabolic process to glutamate(GO:0010133)
11.1 33.2 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
9.6 115.5 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
9.4 56.6 GO:0008218 bioluminescence(GO:0008218)
9.3 27.9 GO:0042427 serotonin biosynthetic process(GO:0042427) phytoalexin metabolic process(GO:0052314)
7.3 80.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
7.1 28.5 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
6.0 60.0 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
5.6 100.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
4.6 18.2 GO:0090293 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
4.4 13.2 GO:0016999 antibiotic metabolic process(GO:0016999)
4.4 17.5 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
4.1 33.1 GO:0015747 urate transport(GO:0015747)
4.0 8.1 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
3.7 29.3 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
3.5 17.7 GO:1903412 response to bile acid(GO:1903412)
3.4 10.3 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
3.4 17.0 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
3.3 9.9 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
3.1 15.7 GO:0061107 seminal vesicle development(GO:0061107)
3.1 12.5 GO:0000023 maltose metabolic process(GO:0000023)
2.7 8.2 GO:0009441 glycolate metabolic process(GO:0009441)
2.7 16.0 GO:0016554 cytidine to uridine editing(GO:0016554)
2.6 13.2 GO:0010193 response to ozone(GO:0010193)
2.6 23.4 GO:0055091 phospholipid homeostasis(GO:0055091)
2.5 30.0 GO:0006069 ethanol oxidation(GO:0006069)
2.5 14.8 GO:0006651 diacylglycerol biosynthetic process(GO:0006651) activation of phospholipase A2 activity(GO:0032431)
2.4 7.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
2.2 6.7 GO:0090675 intermicrovillar adhesion(GO:0090675)
2.1 25.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
2.1 48.9 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
2.1 14.6 GO:0036343 psychomotor behavior(GO:0036343)
2.0 59.2 GO:0042359 vitamin D metabolic process(GO:0042359)
1.8 20.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
1.8 36.8 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
1.4 5.7 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
1.4 4.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.4 24.4 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
1.3 15.5 GO:0070327 thyroid hormone transport(GO:0070327)
1.2 4.9 GO:0010966 regulation of phosphate transport(GO:0010966)
1.2 38.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
1.2 3.5 GO:2000722 regulation of cardiac vascular smooth muscle cell differentiation(GO:2000722)
1.2 15.0 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
1.1 10.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
1.1 3.2 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
1.1 3.2 GO:0015722 canalicular bile acid transport(GO:0015722)
1.0 3.9 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.9 9.5 GO:0052695 cellular glucuronidation(GO:0052695)
0.9 4.5 GO:0044245 polysaccharide digestion(GO:0044245)
0.9 13.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.9 5.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.8 2.5 GO:1990654 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.8 9.9 GO:0006824 cobalt ion transport(GO:0006824)
0.7 2.2 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.7 11.8 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.7 4.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.7 2.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.6 3.9 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.6 31.9 GO:0051180 vitamin transport(GO:0051180)
0.5 11.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.5 2.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.5 3.6 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.5 34.7 GO:0006953 acute-phase response(GO:0006953)
0.5 4.1 GO:0051026 chiasma assembly(GO:0051026)
0.4 3.3 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.4 14.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.4 11.5 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.4 15.4 GO:0010107 potassium ion import(GO:0010107)
0.4 5.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 3.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.3 45.8 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.3 1.3 GO:0038161 prolactin signaling pathway(GO:0038161)
0.3 1.3 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.3 4.1 GO:0038203 TORC2 signaling(GO:0038203)
0.3 3.6 GO:0006265 DNA topological change(GO:0006265)
0.2 3.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 1.8 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 4.6 GO:0060065 uterus development(GO:0060065)
0.2 1.2 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.2 6.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.2 1.0 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.1 0.4 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 3.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 9.8 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.1 8.2 GO:1990748 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.1 17.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 2.6 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 7.2 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 5.6 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.1 0.4 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 1.9 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 4.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 5.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.1 GO:0036233 glycine import(GO:0036233)
0.0 2.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 5.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 4.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 3.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 5.2 GO:0007498 mesoderm development(GO:0007498)
0.0 1.8 GO:0002292 T cell differentiation involved in immune response(GO:0002292)
0.0 0.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 2.2 GO:0030239 myofibril assembly(GO:0030239)
0.0 11.1 GO:0006979 response to oxidative stress(GO:0006979)
0.0 11.8 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 7.4 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.0 3.1 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 108.5 GO:0005577 fibrinogen complex(GO:0005577)
6.9 41.5 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
5.2 15.7 GO:0036027 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
4.4 17.5 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
4.3 34.2 GO:0005579 membrane attack complex(GO:0005579)
4.0 16.0 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
3.2 61.7 GO:0031089 platelet dense granule lumen(GO:0031089)
2.5 20.2 GO:0045179 apical cortex(GO:0045179)
2.5 14.8 GO:0032311 angiogenin-PRI complex(GO:0032311)
2.3 23.2 GO:0046581 intercellular canaliculus(GO:0046581)
2.2 33.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
2.1 17.0 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
2.0 25.7 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.2 9.9 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.1 6.7 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
1.0 5.2 GO:0036398 TCR signalosome(GO:0036398)
0.9 313.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.7 13.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.7 131.2 GO:0072562 blood microparticle(GO:0072562)
0.5 18.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.5 34.0 GO:0031526 brush border membrane(GO:0031526)
0.4 20.7 GO:0034358 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.3 4.7 GO:0031528 microvillus membrane(GO:0031528)
0.3 15.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 3.7 GO:0097512 cardiac myofibril(GO:0097512)
0.2 2.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 4.1 GO:0031932 TORC2 complex(GO:0031932)
0.2 4.1 GO:0032300 mismatch repair complex(GO:0032300)
0.2 3.5 GO:0016580 Sin3 complex(GO:0016580)
0.2 90.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 3.9 GO:0031095 spectrin-associated cytoskeleton(GO:0014731) platelet dense tubular network membrane(GO:0031095)
0.1 27.9 GO:0008021 synaptic vesicle(GO:0008021)
0.1 56.8 GO:0016324 apical plasma membrane(GO:0016324)
0.1 7.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 11.8 GO:0035579 specific granule membrane(GO:0035579)
0.1 25.2 GO:0030133 transport vesicle(GO:0030133)
0.1 37.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 3.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 9.9 GO:0043202 lysosomal lumen(GO:0043202)
0.1 13.2 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 1.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 6.9 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1 8.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 59.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 4.2 GO:0035580 specific granule lumen(GO:0035580)
0.1 4.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 2.2 GO:0005902 microvillus(GO:0005902)
0.0 6.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 52.8 GO:0005615 extracellular space(GO:0005615)
0.0 1.3 GO:0031904 endosome lumen(GO:0031904)
0.0 3.2 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 40.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.9 GO:0009986 cell surface(GO:0009986)
0.0 2.2 GO:0030018 Z disc(GO:0030018)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.0 GO:0005795 Golgi stack(GO:0005795)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
20.1 60.2 GO:1902271 D3 vitamins binding(GO:1902271)
15.4 61.7 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
10.6 31.9 GO:0008431 vitamin E binding(GO:0008431)
10.6 105.8 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
10.1 40.5 GO:0019770 IgG receptor activity(GO:0019770)
5.2 41.5 GO:1990405 protein antigen binding(GO:1990405)
5.1 15.4 GO:0052853 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
4.6 18.2 GO:0038181 bile acid receptor activity(GO:0038181) chenodeoxycholic acid binding(GO:1902122)
4.2 12.5 GO:0004339 glucan 1,4-alpha-glucosidase activity(GO:0004339)
4.0 11.9 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
3.7 30.0 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
3.5 38.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
3.5 31.5 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
3.4 130.3 GO:0001972 retinoic acid binding(GO:0001972)
3.1 36.8 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
3.0 14.8 GO:0004522 ribonuclease A activity(GO:0004522)
2.9 20.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
2.3 9.3 GO:0005499 vitamin D binding(GO:0005499)
2.2 33.2 GO:0015643 toxic substance binding(GO:0015643)
2.1 10.3 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
2.0 9.9 GO:0016841 ammonia-lyase activity(GO:0016841)
1.9 5.8 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
1.9 48.9 GO:0034185 apolipoprotein binding(GO:0034185)
1.6 4.7 GO:0070573 metallodipeptidase activity(GO:0070573)
1.5 17.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.5 7.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
1.3 134.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.3 3.8 GO:0004556 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
1.3 36.9 GO:0071949 FAD binding(GO:0071949)
1.3 10.0 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
1.2 3.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
1.1 3.2 GO:0015265 urea channel activity(GO:0015265)
1.0 4.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
1.0 13.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
1.0 12.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.9 24.4 GO:0031489 myosin V binding(GO:0031489)
0.9 17.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.9 2.6 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.9 3.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.8 7.5 GO:0030274 LIM domain binding(GO:0030274)
0.8 3.3 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.8 5.7 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.8 4.6 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.8 9.9 GO:0031419 cobalamin binding(GO:0031419)
0.7 13.2 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.7 17.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.7 8.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.6 13.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.6 14.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.6 28.5 GO:0008009 chemokine activity(GO:0008009)
0.5 10.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.5 27.9 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.4 3.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.4 2.2 GO:0051373 FATZ binding(GO:0051373)
0.3 11.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 39.3 GO:0051087 chaperone binding(GO:0051087)
0.3 1.3 GO:0004925 prolactin receptor activity(GO:0004925)
0.3 20.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 25.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 17.5 GO:0016209 antioxidant activity(GO:0016209)
0.3 2.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 8.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 0.7 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 6.6 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.2 6.1 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.2 6.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 5.2 GO:0030275 LRR domain binding(GO:0030275)
0.2 4.1 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.2 3.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 4.7 GO:0001848 complement binding(GO:0001848)
0.2 3.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 18.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 4.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 40.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 4.2 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.2 20.2 GO:0005179 hormone activity(GO:0005179)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 2.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 2.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 16.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 8.1 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 5.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 11.8 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 2.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 3.9 GO:0030507 spectrin binding(GO:0030507)
0.1 15.7 GO:0030674 protein binding, bridging(GO:0030674)
0.1 4.9 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 4.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.3 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 3.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 4.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 202.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
2.0 115.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.7 190.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5 25.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 10.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 18.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 20.2 PID CD40 PATHWAY CD40/CD40L signaling
0.2 3.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 17.0 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 6.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 4.6 PID CONE PATHWAY Visual signal transduction: Cones
0.2 5.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 12.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 4.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 6.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 8.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 19.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 5.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 4.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 2.6 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 5.1 PID FGF PATHWAY FGF signaling pathway
0.0 7.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 8.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 87.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
4.7 118.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
3.4 80.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
3.0 30.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
2.6 42.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
2.4 28.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
1.7 60.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
1.6 36.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.6 68.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
1.6 28.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
1.4 27.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
1.3 20.7 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
1.0 17.7 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
1.0 25.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.9 14.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.7 13.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.7 50.7 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.6 17.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.5 17.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 14.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 49.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 4.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 3.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 13.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 8.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 10.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 3.9 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.2 5.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.2 2.0 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 2.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 2.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 20.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 4.1 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 2.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 4.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 3.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 19.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 16.0 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 10.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 3.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 5.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.4 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds