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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HNF4A

Z-value: 5.87

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Transcription factors associated with HNF4A

Gene Symbol Gene ID Gene Info
ENSG00000101076.18 HNF4A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF4Ahg38_v1_chr20_+_44401269_444013010.598.4e-22Click!

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_-_42811884 26.99 ENST00000514985.6
ENST00000511224.5
ENST00000507920.5
ENST00000510965.1
selenoprotein P
chr6_+_31982057 23.68 ENST00000428956.7
ENST00000498271.1
complement C4A (Rodgers blood group)
chr6_+_32014795 23.22 ENST00000435363.7
ENST00000425700.3
complement C4B (Chido blood group)
chr9_-_101442403 20.66 ENST00000648758.1
aldolase, fructose-bisphosphate B
chr1_-_15585015 20.64 ENST00000375826.4
agmatinase
chr16_+_8674605 17.83 ENST00000268251.13
4-aminobutyrate aminotransferase
chr20_+_57561103 17.10 ENST00000319441.6
phosphoenolpyruvate carboxykinase 1
chr17_+_43780425 16.53 ENST00000449302.8
CFAP97 domain containing 1
chr6_+_31946086 13.35 ENST00000425368.7
complement factor B
chr9_+_136945234 12.45 ENST00000371634.7
complement C8 gamma chain
chr5_-_131797030 12.42 ENST00000615660.4
folliculin interacting protein 1
chr17_+_42900791 11.56 ENST00000592383.5
ENST00000253801.7
ENST00000585489.1
glucose-6-phosphatase catalytic subunit 1
chr10_-_17129786 11.01 ENST00000377833.10
cubilin
chr19_-_35812838 10.65 ENST00000653904.2
proline dehydrogenase 2
chr17_+_29043124 10.64 ENST00000323372.9
pipecolic acid and sarcosine oxidase
chr3_-_194351290 10.55 ENST00000429275.1
ENST00000323830.4
carboxypeptidase N subunit 2
chr10_+_94762673 10.52 ENST00000480405.2
ENST00000371321.9
cytochrome P450 family 2 subfamily C member 19
chr19_+_44946043 10.51 ENST00000252490.7
ENST00000591597.5
apolipoprotein C2
chr3_+_37243333 10.18 ENST00000431105.1
golgin A4
chr6_+_43298254 9.89 ENST00000372585.10
ENST00000449231.5
ENST00000372589.7
solute carrier family 22 member 7
chr20_+_59300402 9.84 ENST00000311585.11
ENST00000371028.6
endothelin 3
chr10_+_94683722 9.35 ENST00000285979.11
cytochrome P450 family 2 subfamily C member 18
chr1_+_20633450 9.06 ENST00000321556.5
PTEN induced kinase 1
chr19_+_35138993 8.97 ENST00000612146.4
ENST00000589209.5
FXYD domain containing ion transport regulator 1
chr19_+_41088450 8.70 ENST00000330436.4
cytochrome P450 family 2 subfamily A member 13
chr1_+_94418467 8.56 ENST00000315713.5
ATP binding cassette subfamily D member 3
chr17_+_4771878 8.55 ENST00000270560.4
transmembrane 4 L six family member 5
chr3_-_9878488 8.42 ENST00000443115.1
cell death inducing DFFA like effector c
chr6_+_30626842 8.31 ENST00000318999.11
ENST00000376485.8
ENST00000330083.6
ENST00000319027.9
ENST00000376483.8
ENST00000329992.12
alpha tubulin acetyltransferase 1
chr2_-_221572272 8.18 ENST00000409854.5
ENST00000443796.5
ENST00000281821.7
EPH receptor A4
chr12_+_108880085 8.15 ENST00000228476.8
ENST00000547768.5
D-amino acid oxidase
chr2_+_44275473 8.10 ENST00000260649.11
solute carrier family 3 member 1
chr9_-_133739920 8.02 ENST00000371872.8
ENST00000298628.6
sarcosine dehydrogenase
chr19_-_15125095 7.99 ENST00000600984.5
ilvB acetolactate synthase like
chr1_+_180632001 7.97 ENST00000367590.9
ENST00000367589.3
xenotropic and polytropic retrovirus receptor 1
chr19_+_44946009 7.97 ENST00000592257.5
apolipoprotein C2
chr2_-_227379297 7.96 ENST00000304568.4
transmembrane 4 L six family member 20
chr19_+_1205761 7.91 ENST00000326873.12
ENST00000586243.5
serine/threonine kinase 11
chr1_+_78045956 7.85 ENST00000370759.4
GIPC PDZ domain containing family member 2
chr7_-_126533850 7.75 ENST00000444921.3
glutamate metabotropic receptor 8
chr17_-_7179348 7.59 ENST00000573083.1
ENST00000574388.5
ENST00000269299.8
asialoglycoprotein receptor 1
chr20_+_59300547 7.50 ENST00000644821.1
endothelin 3
chr5_+_80654644 7.50 ENST00000265081.7
mutS homolog 3
chr19_+_35138778 7.50 ENST00000351325.9
ENST00000586871.5
ENST00000592174.1
FXYD domain containing ion transport regulator 1
novel transcript
chr17_+_45962338 7.47 ENST00000415613.6
ENST00000420682.6
ENST00000431008.7
ENST00000571987.5
ENST00000574436.5
microtubule associated protein tau
chr11_+_27055215 7.33 ENST00000525090.1
gamma-butyrobetaine hydroxylase 1
chr16_-_16223467 7.30 ENST00000575728.1
ENST00000574094.6
ENST00000205557.12
ATP binding cassette subfamily C member 6
chr10_-_95069489 7.15 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
cytochrome P450 family 2 subfamily C member 8
chr3_-_124934735 7.13 ENST00000478191.1
ENST00000616727.4
mucin 13, cell surface associated
chr12_-_53727428 7.12 ENST00000548263.5
ENST00000430117.6
ENST00000549173.5
ENST00000550804.6
ENST00000551900.5
ENST00000546619.5
ENST00000548177.5
ENST00000549349.5
calcium binding and coiled-coil domain 1
chr1_-_161223408 7.11 ENST00000491350.1
apolipoprotein A2
chr13_+_113122791 6.82 ENST00000375559.8
ENST00000409306.5
ENST00000375551.7
coagulation factor X
chr15_+_100602519 6.76 ENST00000332783.12
ENST00000558747.5
ENST00000343276.4
ankyrin repeat and SOCS box containing 7
chr3_-_9878765 6.72 ENST00000430427.6
ENST00000383817.5
ENST00000679265.1
cell death inducing DFFA like effector c
chr5_+_31639104 6.67 ENST00000438447.2
PDZ domain containing 2
chr6_-_149484965 6.65 ENST00000409806.8
zinc finger CCCH-type containing 12D
chr10_+_94938649 6.64 ENST00000461906.1
ENST00000260682.8
cytochrome P450 family 2 subfamily C member 9
chr12_-_53727476 6.62 ENST00000549784.5
ENST00000262059.8
calcium binding and coiled-coil domain 1
chr2_-_42792558 6.56 ENST00000431905.1
ENST00000294973.11
3-hydroxyanthranilate 3,4-dioxygenase
chr13_+_113105782 6.50 ENST00000541084.5
ENST00000346342.8
ENST00000375581.3
coagulation factor VII
chrX_-_43882411 6.50 ENST00000378069.5
monoamine oxidase B
chr22_-_42130800 6.42 ENST00000645361.2
ENST00000359033.4
cytochrome P450 family 2 subfamily D member 6
chr17_-_7179544 6.35 ENST00000619926.4
asialoglycoprotein receptor 1
chr1_-_161223559 6.23 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
apolipoprotein A2
chr7_+_45888360 6.23 ENST00000457280.5
insulin like growth factor binding protein 1
chr18_+_32190015 6.20 ENST00000581447.1
meprin A subunit beta
chr17_+_1742836 6.11 ENST00000324015.7
ENST00000450523.6
ENST00000453723.5
ENST00000453066.6
ENST00000382061.5
serpin family F member 2
chr18_+_32190033 6.09 ENST00000269202.11
meprin A subunit beta
chr3_-_42875871 5.90 ENST00000316161.6
ENST00000437102.1
cytochrome P450 family 8 subfamily B member 1
chr17_-_37745018 5.84 ENST00000613727.4
ENST00000614313.4
ENST00000617811.5
ENST00000621123.4
HNF1 homeobox B
chr7_-_87475839 5.69 ENST00000359206.8
ATP binding cassette subfamily B member 4
chr19_+_15641280 5.67 ENST00000585846.1
cytochrome P450 family 4 subfamily F member 3
chr1_+_28369705 5.61 ENST00000373839.8
phosphatase and actin regulator 4
chr1_-_201399525 5.57 ENST00000367313.4
ladinin 1
chr4_-_10021490 5.49 ENST00000264784.8
solute carrier family 2 member 9
chr19_-_38812936 5.47 ENST00000307751.9
ENST00000594209.1
galectin 4
chr12_+_55720405 5.44 ENST00000548082.1
retinol dehydrogenase 5
chr15_-_40828699 5.40 ENST00000299174.10
ENST00000427255.2
protein phosphatase 1 regulatory inhibitor subunit 14D
chr1_-_161238085 5.37 ENST00000512372.5
ENST00000437437.6
ENST00000412844.6
ENST00000428574.6
ENST00000442691.6
ENST00000505005.5
ENST00000508740.5
ENST00000367981.7
ENST00000502985.5
ENST00000504010.5
ENST00000508387.5
ENST00000511676.5
ENST00000511748.5
ENST00000511944.5
ENST00000515621.5
ENST00000367984.8
ENST00000367985.7
nuclear receptor subfamily 1 group I member 3
chr4_-_119322128 5.36 ENST00000274024.4
fatty acid binding protein 2
chr4_+_112231748 5.34 ENST00000274000.10
ENST00000309703.10
adaptor related protein complex 1 associated regulatory protein
chr12_+_55720367 5.33 ENST00000547072.5
ENST00000552930.5
ENST00000257895.10
retinol dehydrogenase 5
chr1_+_196888014 5.23 ENST00000367416.6
ENST00000608469.6
ENST00000251424.8
ENST00000367418.2
complement factor H related 4
chr7_+_45888479 5.21 ENST00000275525.8
ENST00000468955.1
insulin like growth factor binding protein 1
chr18_+_56651385 5.21 ENST00000615645.4
WD repeat domain 7
chr18_+_56651335 5.09 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WD repeat domain 7
chr19_+_4639505 5.06 ENST00000327473.9
TNF alpha induced protein 8 like 1
chr20_-_45857196 4.95 ENST00000457981.5
ENST00000426915.1
ENST00000217455.9
acyl-CoA thioesterase 8
chr16_+_66844408 4.91 ENST00000338437.7
carbonic anhydrase 7
chr2_+_218568809 4.88 ENST00000273064.11
CCR4-NOT transcription complex subunit 9
chr20_+_59300589 4.81 ENST00000337938.7
ENST00000371025.7
endothelin 3
chr20_+_59300703 4.77 ENST00000395654.3
endothelin 3
chrX_+_118974608 4.63 ENST00000304778.11
ENST00000371628.8
LON peptidase N-terminal domain and ring finger 3
chr19_+_39125769 4.56 ENST00000602004.1
ENST00000599470.5
ENST00000321944.8
ENST00000593480.5
ENST00000358301.7
ENST00000593690.5
ENST00000599386.5
p21 (RAC1) activated kinase 4
chr11_-_74009077 4.55 ENST00000314032.9
ENST00000426995.2
uncoupling protein 3
chr2_-_62506136 4.53 ENST00000335390.6
transmembrane protein 17
chr7_+_100949525 4.48 ENST00000379458.9
ENST00000483366.5
mucin 3A, cell surface associated
chr16_+_83998252 4.47 ENST00000564166.1
N-terminal EF-hand calcium binding protein 2
chr17_+_75610690 4.41 ENST00000642007.1
myosin XVB
chr19_+_48552159 4.40 ENST00000201586.7
sulfotransferase family 2B member 1
chr1_+_43389889 4.37 ENST00000562955.2
ENST00000634258.3
SZT2 subunit of KICSTOR complex
chr17_-_46818680 4.35 ENST00000225512.6
Wnt family member 3
chr2_-_27890348 4.34 ENST00000302188.8
ribokinase
chr1_-_161238163 4.32 ENST00000367982.8
nuclear receptor subfamily 1 group I member 3
chr11_+_75159780 4.28 ENST00000525845.5
ENST00000534186.5
ENST00000428359.6
solute carrier organic anion transporter family member 2B1
chrX_+_38352573 4.27 ENST00000039007.5
ornithine transcarbamylase
chr1_-_161238196 4.26 ENST00000367983.9
ENST00000506209.5
ENST00000367980.6
ENST00000628566.2
nuclear receptor subfamily 1 group I member 3
chr17_+_63477052 4.24 ENST00000290866.10
ENST00000428043.5
angiotensin I converting enzyme
chr3_+_124094663 4.15 ENST00000460856.5
ENST00000240874.7
kalirin RhoGEF kinase
chr11_+_63369779 4.13 ENST00000279178.4
solute carrier family 22 member 9
chr11_-_45917867 4.12 ENST00000378750.10
peroxisomal biogenesis factor 16
chr19_+_10086305 4.12 ENST00000253110.16
ENST00000591813.5
shiftless antiviral inhibitor of ribosomal frameshifting
chr2_+_218568558 4.08 ENST00000627282.2
ENST00000542068.5
CCR4-NOT transcription complex subunit 9
chr20_+_64063105 4.03 ENST00000395053.7
ENST00000343484.10
ENST00000339217.8
transcription elongation factor A2
chr19_-_40750302 3.99 ENST00000598485.6
ENST00000378313.7
ENST00000470681.5
chromosome 19 open reading frame 54
chr2_+_172860038 3.97 ENST00000538974.5
ENST00000540783.5
Rap guanine nucleotide exchange factor 4
chr19_-_48835823 3.95 ENST00000595764.1
hydroxysteroid 17-beta dehydrogenase 14
chr3_+_46877705 3.93 ENST00000449590.6
parathyroid hormone 1 receptor
chr14_+_102922639 3.93 ENST00000299155.10
amnion associated transmembrane protein
chr19_+_39391323 3.91 ENST00000615911.4
ENST00000315588.11
ENST00000594368.5
ENST00000596297.1
mediator complex subunit 29
chr16_+_66844914 3.69 ENST00000394069.3
carbonic anhydrase 7
chr2_+_48568981 3.65 ENST00000394754.5
STON1-GTF2A1L readthrough
chr3_-_120682215 3.57 ENST00000283871.10
homogentisate 1,2-dioxygenase
chr9_+_27109135 3.54 ENST00000519097.5
ENST00000615002.4
TEK receptor tyrosine kinase
chr1_-_145707387 3.54 ENST00000451928.6
PDZ domain containing 1
chr17_-_29176752 3.41 ENST00000533112.5
myosin XVIIIA
chr16_-_87936529 3.39 ENST00000649794.3
ENST00000649158.1
ENST00000648177.1
carbonic anhydrase 5A
chr7_-_87475647 3.36 ENST00000649586.2
ENST00000265723.8
ATP binding cassette subfamily B member 4
chr14_+_39267055 3.31 ENST00000396158.6
ENST00000280083.7
ENST00000341502.9
MIA SH3 domain ER export factor 2
chr9_+_27109200 3.25 ENST00000380036.10
TEK receptor tyrosine kinase
chr1_-_155301423 3.19 ENST00000342741.6
pyruvate kinase L/R
chr1_-_145707345 3.19 ENST00000417171.6
PDZ domain containing 1
chr3_+_124094696 3.17 ENST00000360013.7
ENST00000684186.1
ENST00000684276.1
kalirin RhoGEF kinase
chrX_+_154411519 3.17 ENST00000612460.5
ENST00000601016.6
ENST00000613002.4
ENST00000475699.6
ENST00000612012.5
ENST00000369776.8
ENST00000439735.2
ENST00000616020.5
ENST00000652358.1
ENST00000652390.1
tafazzin
chr18_+_59225492 3.14 ENST00000456142.3
ENST00000530323.1
gastrin releasing peptide
chr11_+_63888515 3.10 ENST00000509502.6
ENST00000512060.1
microtubule affinity regulating kinase 2
chr16_+_19417875 2.97 ENST00000542583.7
transmembrane channel like 5
chr4_-_81215185 2.97 ENST00000264399.6
protein kinase cGMP-dependent 2
chr1_-_161238223 2.96 ENST00000515452.1
nuclear receptor subfamily 1 group I member 3
chr3_+_63912588 2.92 ENST00000522345.2
ataxin 7
chr3_+_119782094 2.90 ENST00000393716.8
nuclear receptor subfamily 1 group I member 2
chr17_-_2711633 2.86 ENST00000435359.5
clustered mitochondria homolog
chr14_+_100019375 2.69 ENST00000544450.6
Enah/Vasp-like
chrX_+_66162663 2.67 ENST00000519389.6
hephaestin
chr1_+_241532370 2.65 ENST00000366559.9
ENST00000366557.8
kynurenine 3-monooxygenase
chr11_-_45917823 2.64 ENST00000533151.5
ENST00000241041.7
peroxisomal biogenesis factor 16
chr3_+_63911929 2.62 ENST00000487717.5
ataxin 7
chr10_-_102056116 2.59 ENST00000370033.9
ENST00000311122.5
armadillo like helical domain containing 3
chr3_+_108822759 2.47 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr11_-_707063 2.47 ENST00000683307.1
DEAF1 transcription factor
chr3_+_108822778 2.43 ENST00000295756.11
T cell receptor associated transmembrane adaptor 1
chr12_+_120978686 2.41 ENST00000541395.5
ENST00000544413.2
HNF1 homeobox A
chr5_-_32444722 2.37 ENST00000265069.13
zinc finger RNA binding protein
chr17_-_2711736 2.34 ENST00000651024.2
ENST00000576885.5
ENST00000574426.7
clustered mitochondria homolog
chr5_-_16508951 2.26 ENST00000682628.1
reticulophagy regulator 1
chr17_+_80178499 2.23 ENST00000570421.5
ENST00000344227.6
caspase recruitment domain family member 14
chr1_+_241532121 2.21 ENST00000366558.7
kynurenine 3-monooxygenase
chr5_-_16508812 2.19 ENST00000683414.1
reticulophagy regulator 1
chr2_-_208129824 2.18 ENST00000282141.4
crystallin gamma C
chr19_-_35852495 2.15 ENST00000378910.10
NPHS1 adhesion molecule, nephrin
chr12_-_7018465 2.13 ENST00000261407.9
lysophosphatidylcholine acyltransferase 3
chr5_-_16508858 2.09 ENST00000684456.1
reticulophagy regulator 1
chr2_-_31414694 2.07 ENST00000379416.4
xanthine dehydrogenase
chr1_+_200027702 2.06 ENST00000367362.8
nuclear receptor subfamily 5 group A member 2
chr19_+_42269219 2.06 ENST00000681038.1
capicua transcriptional repressor
chr8_-_66667138 2.03 ENST00000310421.5
valosin containing protein interacting protein 1
chr10_+_18400562 2.01 ENST00000377315.5
ENST00000650685.1
calcium voltage-gated channel auxiliary subunit beta 2
chr6_+_43298326 1.99 ENST00000372574.7
solute carrier family 22 member 7
chr5_-_16508990 1.98 ENST00000399793.6
reticulophagy regulator 1
chr7_-_15561986 1.87 ENST00000342526.8
alkylglycerol monooxygenase
chr19_+_35371290 1.86 ENST00000597214.1
G protein-coupled receptor 42
chr6_+_30163188 1.82 ENST00000619857.4
tripartite motif containing 15
chrX_-_77786198 1.80 ENST00000624032.3
ENST00000624668.3
ENST00000373344.11
ENST00000395603.7
ENST00000624166.3
ENST00000623321.3
ENST00000622960.1
ATRX chromatin remodeler
chr10_-_20897288 1.73 ENST00000377122.9
nebulette
chr6_+_31959130 1.72 ENST00000375394.7
ENST00000628157.1
Ski2 like RNA helicase
chr17_-_17591658 1.66 ENST00000435340.6
ENST00000255389.10
ENST00000395781.6
phosphatidylethanolamine N-methyltransferase
chr5_-_16508788 1.65 ENST00000682142.1
reticulophagy regulator 1
chr10_+_94683771 1.62 ENST00000339022.6
cytochrome P450 family 2 subfamily C member 18
chr12_+_53103479 1.58 ENST00000301466.8
ENST00000551896.5
sterol O-acyltransferase 2
chr12_-_6556034 1.51 ENST00000619571.5
ENST00000336604.8
ENST00000396840.6
ENST00000356896.8
intermediate filament family orphan 1
chr1_-_40665435 1.48 ENST00000372683.1
regulating synaptic membrane exocytosis 3
chr11_-_45918014 1.47 ENST00000525192.5
peroxisomal biogenesis factor 16
chr3_-_187291882 1.42 ENST00000392470.6
ENST00000169293.10
ENST00000439271.1
ENST00000392472.6
ENST00000392475.2
mannan binding lectin serine peptidase 1
chr15_+_81196871 1.28 ENST00000559383.5
ENST00000394660.6
ENST00000683961.1
interleukin 16
chr1_-_155300979 1.27 ENST00000392414.7
pyruvate kinase L/R
chr19_+_751104 1.23 ENST00000215582.8
mitotic spindle positioning
chr6_+_46793379 1.23 ENST00000230588.9
ENST00000611727.2
meprin A subunit alpha
chr6_-_31897200 1.15 ENST00000395728.7
ENST00000375528.8
euchromatic histone lysine methyltransferase 2
chr3_+_50269140 1.13 ENST00000616701.5
ENST00000433753.4
ENST00000611067.4
semaphorin 3B
chr14_+_38207893 1.09 ENST00000267377.3
somatostatin receptor 1
chr19_-_58511981 1.08 ENST00000263093.7
ENST00000601355.1
solute carrier family 27 member 5
chr19_+_10086787 1.05 ENST00000590378.5
ENST00000397881.7
shiftless antiviral inhibitor of ribosomal frameshifting
chr19_+_15615211 1.01 ENST00000617645.4
ENST00000612078.5
cytochrome P450 family 4 subfamily F member 8
chr20_-_3663399 1.00 ENST00000290417.7
ENST00000319242.8
GDNF family receptor alpha 4
chr1_+_200027605 0.90 ENST00000236914.7
nuclear receptor subfamily 5 group A member 2
chr20_-_7940444 0.88 ENST00000378789.4
hydroxyacid oxidase 1
chr16_+_81238682 0.80 ENST00000258168.7
ENST00000564552.1
beta-carotene oxygenase 1
chr2_+_73214233 0.77 ENST00000389501.9
ENST00000629411.2
SMYD family member 5
chr17_-_3636239 0.74 ENST00000225519.5
sedoheptulokinase
chr2_+_190927649 0.72 ENST00000409428.5
ENST00000409215.5
glutaminase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.1 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
4.7 18.8 GO:0006562 proline catabolic process(GO:0006562)
4.5 31.8 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
4.5 9.0 GO:1905237 response to cyclosporin A(GO:1905237)
4.5 17.8 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
4.3 46.9 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
4.1 20.6 GO:1901162 primary amino compound biosynthetic process(GO:1901162)
3.8 26.9 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
3.4 20.7 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
3.4 27.0 GO:0001887 selenium compound metabolic process(GO:0001887)
3.4 23.6 GO:0016098 monoterpenoid metabolic process(GO:0016098)
3.3 16.5 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
2.9 8.6 GO:0035565 regulation of pronephros size(GO:0035565)
2.9 11.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
2.7 16.5 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
2.7 8.2 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
2.7 8.0 GO:1901053 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
2.7 10.6 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
2.5 12.4 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
2.2 9.0 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
2.1 8.2 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
1.9 5.6 GO:0061386 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.8 7.2 GO:0002933 lipid hydroxylation(GO:0002933)
1.7 8.6 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
1.7 10.2 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.6 6.5 GO:0033594 response to hydroxyisoflavone(GO:0033594)
1.5 4.4 GO:0000103 sulfate assimilation(GO:0000103)
1.4 8.7 GO:0009804 coumarin metabolic process(GO:0009804)
1.4 4.3 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
1.4 4.3 GO:0097272 ammonia homeostasis(GO:0097272)
1.3 25.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.3 10.2 GO:0061709 reticulophagy(GO:0061709)
1.2 14.9 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
1.2 8.1 GO:0015811 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
1.1 3.4 GO:1903028 positive regulation of opsonization(GO:1903028)
1.1 7.9 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
1.1 4.5 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021)
1.1 6.5 GO:0045915 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
1.1 4.2 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
1.0 11.0 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.0 3.0 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.9 5.7 GO:0036102 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.9 6.5 GO:0072501 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.9 0.9 GO:0009441 glycolate metabolic process(GO:0009441)
0.9 6.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.9 4.3 GO:0019323 pentose catabolic process(GO:0019323)
0.9 6.8 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.8 6.8 GO:0048014 Tie signaling pathway(GO:0048014)
0.8 7.3 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.8 15.1 GO:0034389 lipid particle organization(GO:0034389)
0.7 7.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.7 4.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.7 8.3 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.7 2.1 GO:0006145 purine nucleobase catabolic process(GO:0006145) xanthine metabolic process(GO:0046110)
0.6 3.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.6 3.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.6 1.8 GO:0099404 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.6 3.0 GO:0061113 pancreas morphogenesis(GO:0061113)
0.6 2.9 GO:0046618 drug export(GO:0046618)
0.6 20.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.6 4.5 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.6 5.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.5 7.5 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.5 5.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.5 1.5 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.5 5.5 GO:0046415 urate metabolic process(GO:0046415)
0.5 1.9 GO:0046485 ether lipid metabolic process(GO:0046485)
0.5 7.7 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.4 3.6 GO:0006572 tyrosine catabolic process(GO:0006572)
0.4 11.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.4 6.7 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.4 5.0 GO:0016559 peroxisome fission(GO:0016559)
0.4 7.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.4 11.6 GO:0042572 retinol metabolic process(GO:0042572)
0.3 2.0 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.3 4.5 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 4.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.3 6.7 GO:0015879 carnitine transport(GO:0015879)
0.2 0.7 GO:0035963 cellular response to interleukin-13(GO:0035963)
0.2 12.3 GO:1901998 toxin transport(GO:1901998)
0.2 13.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 1.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.2 1.7 GO:0050747 sphingomyelin biosynthetic process(GO:0006686) positive regulation of lipoprotein metabolic process(GO:0050747)
0.2 2.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 2.0 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.2 1.7 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.2 4.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 7.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.2 16.9 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.2 5.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 3.9 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 1.6 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.1 15.8 GO:0030449 regulation of complement activation(GO:0030449)
0.1 5.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 13.7 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.1 0.7 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 1.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 4.5 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.1 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.1 2.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 2.5 GO:0033599 regulation of mammary gland epithelial cell proliferation(GO:0033599)
0.1 3.1 GO:0051646 mitochondrion localization(GO:0051646)
0.1 0.4 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 0.7 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 3.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.5 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 1.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.1 4.3 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 1.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.6 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 4.6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.2 GO:1904970 brush border assembly(GO:1904970)
0.0 1.5 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 5.2 GO:0060996 dendritic spine development(GO:0060996)
0.0 7.9 GO:0007601 visual perception(GO:0007601)
0.0 4.5 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.5 GO:0035855 megakaryocyte development(GO:0035855)
0.0 1.1 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.0 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 2.2 GO:0031295 T cell costimulation(GO:0031295)
0.0 8.0 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.0 1.0 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 2.3 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 17.8 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
2.6 18.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
1.8 11.0 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.6 7.9 GO:0036398 TCR signalosome(GO:0036398)
1.6 12.5 GO:0005579 membrane attack complex(GO:0005579)
1.5 7.5 GO:0032302 MutSbeta complex(GO:0032302)
1.3 27.0 GO:0031089 platelet dense granule lumen(GO:0031089)
1.2 7.5 GO:0045298 tubulin complex(GO:0045298)
1.2 13.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
1.1 9.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
1.0 11.4 GO:0097427 microtubule bundle(GO:0097427)
0.9 16.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.9 9.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.6 4.4 GO:1990130 Iml1 complex(GO:1990130)
0.6 1.8 GO:0031933 telomeric heterochromatin(GO:0031933)
0.6 1.7 GO:0055087 Ski complex(GO:0055087)
0.5 6.1 GO:0005577 fibrinogen complex(GO:0005577)
0.5 20.7 GO:0034451 centriolar satellite(GO:0034451)
0.3 8.2 GO:0044295 axonal growth cone(GO:0044295)
0.3 62.7 GO:0072562 blood microparticle(GO:0072562)
0.3 8.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.3 21.1 GO:0031526 brush border membrane(GO:0031526)
0.3 2.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.3 4.3 GO:1990909 Wnt signalosome(GO:1990909)
0.3 4.5 GO:0036038 MKS complex(GO:0036038)
0.2 6.8 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.2 10.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 7.9 GO:0009925 basal plasma membrane(GO:0009925)
0.2 4.9 GO:0042101 T cell receptor complex(GO:0042101)
0.2 10.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 18.1 GO:0005796 Golgi lumen(GO:0005796)
0.1 15.1 GO:0005811 lipid particle(GO:0005811)
0.1 3.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 2.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 30.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 3.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 5.6 GO:0005604 basement membrane(GO:0005604)
0.1 11.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 10.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 14.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.3 GO:0030133 transport vesicle(GO:0030133)
0.0 2.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 42.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.6 GO:0016592 mediator complex(GO:0016592)
0.0 5.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 42.5 GO:0005615 extracellular space(GO:0005615)
0.0 11.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 16.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 4.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 6.7 GO:0030027 lamellipodium(GO:0030027)
0.0 3.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 7.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 33.3 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 7.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.0 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 20.7 GO:0061609 fructose-1-phosphate aldolase activity(GO:0061609)
5.7 17.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
4.6 18.5 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
4.5 26.9 GO:0031708 endothelin B receptor binding(GO:0031708)
4.5 17.8 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
3.4 23.7 GO:0001849 complement component C1q binding(GO:0001849)
3.1 12.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
2.8 16.9 GO:0004882 androgen receptor activity(GO:0004882)
2.8 13.8 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
2.7 8.0 GO:0008480 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
2.7 13.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
2.4 7.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
2.2 27.0 GO:0008430 selenium binding(GO:0008430)
2.1 10.6 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
2.0 8.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
2.0 13.9 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
1.9 5.7 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
1.9 30.2 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
1.9 49.0 GO:0001848 complement binding(GO:0001848)
1.9 7.5 GO:0099609 microtubule lateral binding(GO:0099609)
1.8 5.3 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
1.7 6.7 GO:0005124 scavenger receptor binding(GO:0005124)
1.7 5.0 GO:0052815 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
1.5 9.0 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
1.5 7.5 GO:0032181 double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
1.5 4.5 GO:0031687 A2A adenosine receptor binding(GO:0031687)
1.4 8.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.4 20.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
1.2 8.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
1.1 4.5 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.1 4.5 GO:0004743 pyruvate kinase activity(GO:0004743)
1.1 5.5 GO:0016936 galactoside binding(GO:0016936)
1.1 9.6 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
1.0 11.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.9 4.5 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.9 8.0 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.8 4.2 GO:0008241 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
0.8 11.0 GO:0031419 cobalamin binding(GO:0031419)
0.8 9.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.8 8.2 GO:0042731 PH domain binding(GO:0042731)
0.8 23.7 GO:0071949 FAD binding(GO:0071949)
0.8 4.0 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.8 3.9 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.8 5.3 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.7 7.4 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) aromatase activity(GO:0070330)
0.7 12.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.6 6.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.6 16.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.6 4.4 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.6 1.8 GO:0015616 DNA translocase activity(GO:0015616)
0.6 3.0 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.6 13.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.6 10.8 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.6 5.6 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.6 1.7 GO:0080101 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.5 1.6 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.5 2.1 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.5 7.3 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.5 4.3 GO:0042301 phosphate ion binding(GO:0042301)
0.4 0.9 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.4 5.9 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.4 10.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 10.9 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 2.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 7.9 GO:0030275 LRR domain binding(GO:0030275)
0.3 4.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 1.9 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 16.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 0.7 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.2 7.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 1.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 4.8 GO:0048018 receptor agonist activity(GO:0048018)
0.2 2.2 GO:0050700 CARD domain binding(GO:0050700)
0.2 5.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 7.7 GO:0008066 glutamate receptor activity(GO:0008066)
0.2 9.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 2.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 4.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.0 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 2.7 GO:0005522 profilin binding(GO:0005522)
0.1 1.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.7 GO:0004359 glutaminase activity(GO:0004359)
0.1 3.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 13.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 4.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 1.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 3.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0030249 cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.1 5.4 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.7 GO:0031005 filamin binding(GO:0031005)
0.1 6.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 2.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 4.0 GO:0030552 cAMP binding(GO:0030552)
0.1 3.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 5.9 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.4 GO:0043531 ADP binding(GO:0043531)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 6.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 14.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 5.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 5.3 GO:0004519 endonuclease activity(GO:0004519)
0.0 4.4 GO:0003774 motor activity(GO:0003774)
0.0 3.1 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 8.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.7 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 62.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.6 13.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.4 10.8 PID CONE PATHWAY Visual signal transduction: Cones
0.4 7.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 7.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.3 26.9 PID ENDOTHELIN PATHWAY Endothelins
0.2 8.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 6.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 12.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 11.0 PID LKB1 PATHWAY LKB1 signaling events
0.2 13.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 11.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 16.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 6.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 4.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 4.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 18.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 20.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.3 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 50.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
2.0 38.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
1.6 11.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
1.4 31.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.1 17.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
1.0 20.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.8 11.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.8 14.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.7 12.0 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.7 13.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.6 7.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.5 12.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.5 11.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 17.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.4 25.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.4 5.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.4 7.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 7.9 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.3 7.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 5.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 4.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 7.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 22.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 13.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 4.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 4.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 5.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.2 2.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 8.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 8.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 37.4 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 2.1 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 3.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 4.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 7.6 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.1 2.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 24.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 8.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 3.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 6.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.1 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 1.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors