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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXA1

Z-value: 4.23

Motif logo

Transcription factors associated with HOXA1

Gene Symbol Gene ID Gene Info
ENSG00000105991.10 HOXA1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA1hg38_v1_chr7_-_27095972_27096039-0.129.0e-02Click!

Activity profile of HOXA1 motif

Sorted Z-values of HOXA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr8_+_103140692 56.49 ENST00000438105.2
ENST00000309982.10
ENST00000297574.6
BAALC binder of MAP3K1 and KLF4
chr20_-_23637933 39.95 ENST00000398411.5
cystatin C
chr16_+_83968244 34.18 ENST00000305202.9
N-terminal EF-hand calcium binding protein 2
chr20_-_23637947 33.11 ENST00000376925.8
cystatin C
chr8_-_27611325 27.65 ENST00000523500.5
clusterin
chr5_-_42825884 25.85 ENST00000506577.5
selenoprotein P
chr17_-_44911281 21.83 ENST00000638304.1
ENST00000591880.2
ENST00000586125.2
ENST00000639921.1
glial fibrillary acidic protein
chr8_-_27605271 20.52 ENST00000522098.1
clusterin
chr8_-_27258414 19.91 ENST00000523048.5
stathmin 4
chr8_-_27611424 19.68 ENST00000405140.7
clusterin
chr20_+_45408276 18.38 ENST00000372710.5
ENST00000443296.1
dysbindin domain containing 2
chr1_+_2073986 17.87 ENST00000461106.6
protein kinase C zeta
chr14_+_99684283 16.37 ENST00000261835.8
cytochrome P450 family 46 subfamily A member 1
chr8_-_27258386 16.36 ENST00000350889.8
ENST00000519997.5
ENST00000519614.5
ENST00000522908.1
ENST00000265770.11
stathmin 4
chr2_+_24049705 14.81 ENST00000380986.9
ENST00000452109.1
FKBP prolyl isomerase 1B
chrX_-_13817027 14.73 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr6_+_39792993 14.29 ENST00000538976.5
dishevelled associated activator of morphogenesis 2
chr11_-_72642407 14.21 ENST00000376450.7
phosphodiesterase 2A
chr6_+_39793008 13.97 ENST00000398904.6
dishevelled associated activator of morphogenesis 2
chr11_-_72642450 13.94 ENST00000444035.6
ENST00000544570.5
phosphodiesterase 2A
chr4_+_165378998 13.57 ENST00000402744.9
carboxypeptidase E
chr7_+_154305105 13.40 ENST00000332007.7
dipeptidyl peptidase like 6
chr2_-_50347789 13.25 ENST00000628364.2
neurexin 1
chrX_-_73214793 12.57 ENST00000373517.4
nucleosome assembly protein 1 like 2
chr20_+_36154630 12.38 ENST00000338074.7
ENST00000636016.2
ENST00000373945.5
erythrocyte membrane protein band 4.1 like 1
chr4_+_113049616 12.20 ENST00000504454.5
ENST00000357077.9
ENST00000394537.7
ENST00000672779.1
ENST00000264366.10
ankyrin 2
chr7_-_137343688 11.62 ENST00000348225.7
pleiotrophin
chr17_-_1229706 11.42 ENST00000574139.7
ABR activator of RhoGEF and GTPase
chr16_+_15502266 11.27 ENST00000452191.6
bMERB domain containing 1
chr11_-_5227063 11.09 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
hemoglobin subunit beta
chr3_+_159839847 10.52 ENST00000445224.6
schwannomin interacting protein 1
chr2_+_24049673 10.31 ENST00000380991.8
FKBP prolyl isomerase 1B
chr3_+_150546765 10.18 ENST00000406576.7
ENST00000460851.6
ENST00000482093.5
ENST00000273435.9
eukaryotic translation initiation factor 2A
chr16_+_23835946 9.99 ENST00000321728.12
ENST00000643927.1
protein kinase C beta
chr2_+_230864921 9.87 ENST00000326427.11
ENST00000335005.10
ENST00000326407.10
integral membrane protein 2C
chr7_-_137343752 9.85 ENST00000393083.2
pleiotrophin
chr4_+_113049479 9.84 ENST00000671727.1
ENST00000671762.1
ENST00000672366.1
ENST00000672502.1
ENST00000672045.1
ENST00000672251.1
ENST00000672854.1
ankyrin 2
chr4_+_153257339 9.68 ENST00000676374.1
ENST00000676196.1
ENST00000674935.1
ENST00000674769.1
ENST00000674896.1
ENST00000676191.1
ENST00000675312.1
ENST00000675456.1
ENST00000674847.1
ENST00000675977.1
ENST00000676264.1
ENST00000674726.1
ENST00000676252.1
ENST00000674730.1
ENST00000675738.1
ENST00000482578.3
tripartite motif containing 2
chr11_+_26188836 9.18 ENST00000672621.1
anoctamin 3
chr4_-_86101922 8.79 ENST00000472236.5
ENST00000641881.1
mitogen-activated protein kinase 10
chr11_-_104164126 8.52 ENST00000393158.7
platelet derived growth factor D
chr1_+_65264694 8.34 ENST00000263441.11
ENST00000395325.7
DnaJ heat shock protein family (Hsp40) member C6
chr3_+_159852933 8.27 ENST00000482804.1
schwannomin interacting protein 1
chr2_-_44361555 7.76 ENST00000409957.5
prolyl endopeptidase like
chr8_-_90082871 7.75 ENST00000265431.7
calbindin 1
chr2_-_50347710 7.54 ENST00000342183.9
ENST00000401710.5
neurexin 1
chr4_+_70721953 7.52 ENST00000381006.8
ENST00000226328.8
RUN and FYVE domain containing 3
chr12_-_91146195 7.30 ENST00000548218.1
decorin
chr5_+_140834230 7.16 ENST00000356878.5
ENST00000525929.2
protocadherin alpha 7
chr6_+_32024278 6.73 ENST00000647698.1
complement C4B (Chido blood group)
chr20_+_9514562 6.34 ENST00000246070.3
lysosomal associated membrane protein family member 5
chr6_+_17393576 6.18 ENST00000229922.7
ENST00000611958.4
cyclase associated actin cytoskeleton regulatory protein 2
chr11_-_104164361 5.98 ENST00000302251.9
platelet derived growth factor D
chr6_+_17393505 5.94 ENST00000616440.4
cyclase associated actin cytoskeleton regulatory protein 2
chr1_+_205504592 5.89 ENST00000506784.5
ENST00000360066.6
cyclin dependent kinase 18
chr6_+_17393607 5.79 ENST00000489374.5
ENST00000378990.6
cyclase associated actin cytoskeleton regulatory protein 2
chr10_+_7703340 5.54 ENST00000429820.5
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chrM_+_4467 5.52 ENST00000361453.3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
chr1_-_13201409 5.50 ENST00000625019.3
PRAME family member 13
chr11_+_125904467 5.50 ENST00000263576.11
ENST00000530414.5
ENST00000530129.6
DEAD-box helicase 25
chr12_+_12725897 5.24 ENST00000326765.10
apolipoprotein L domain containing 1
chr9_-_94640130 5.09 ENST00000414122.1
fructose-bisphosphatase 1
chrX_-_57910458 4.88 ENST00000358697.6
zinc finger X-linked duplicated A
chr9_-_94640248 4.88 ENST00000415431.5
fructose-bisphosphatase 1
chr5_-_784691 4.85 ENST00000508859.8
ENST00000652055.1
ENST00000651083.1
zinc finger DHHC-type containing 11B
chr3_+_38496467 4.83 ENST00000453767.1
exo/endonuclease G
chr1_-_13347134 4.79 ENST00000334600.7
PRAME family member 14
chr7_-_22193824 4.73 ENST00000401957.6
Rap guanine nucleotide exchange factor 5
chr8_+_22275309 4.72 ENST00000356766.11
ENST00000521356.5
piwi like RNA-mediated gene silencing 2
chr9_-_10612966 4.72 ENST00000381196.9
protein tyrosine phosphatase receptor type D
chr6_-_13487593 4.62 ENST00000379287.4
ENST00000603223.1
glucose-fructose oxidoreductase domain containing 1
chr2_-_152098810 4.54 ENST00000636442.1
ENST00000638005.1
calcium voltage-gated channel auxiliary subunit beta 4
chr9_-_83956677 4.52 ENST00000376344.8
chromosome 9 open reading frame 64
chr7_-_22193728 4.39 ENST00000620335.4
Rap guanine nucleotide exchange factor 5
chr8_+_142449430 4.36 ENST00000643448.1
ENST00000517894.5
adhesion G protein-coupled receptor B1
chr7_+_80135694 4.36 ENST00000457358.7
G protein subunit alpha i1
chr3_-_129893551 4.31 ENST00000505616.5
ENST00000426664.6
ENST00000648771.1
ENST00000393238.8
transmembrane and coiled-coil domain family 1
chrX_-_6227180 4.31 ENST00000381093.6
neuroligin 4 X-linked
chr1_-_201399525 4.16 ENST00000367313.4
ladinin 1
chr3_+_4493442 4.13 ENST00000456211.8
ENST00000443694.5
ENST00000648266.1
inositol 1,4,5-trisphosphate receptor type 1
chr10_+_7703300 4.13 ENST00000358415.9
inter-alpha-trypsin inhibitor heavy chain 2
chr19_+_840991 4.12 ENST00000234347.10
proteinase 3
chr3_+_4493471 4.11 ENST00000544951.6
ENST00000650294.1
inositol 1,4,5-trisphosphate receptor type 1
chr6_+_151239951 3.95 ENST00000402676.7
A-kinase anchoring protein 12
chr16_+_75222609 3.94 ENST00000495583.1
chymotrypsinogen B1
chr11_-_89065969 3.92 ENST00000305447.5
glutamate metabotropic receptor 5
chr3_+_4493340 3.88 ENST00000357086.10
ENST00000354582.12
ENST00000649015.2
ENST00000467056.6
inositol 1,4,5-trisphosphate receptor type 1
chr5_-_20575850 3.85 ENST00000507958.5
cadherin 18
chr19_+_13764502 3.82 ENST00000040663.8
ENST00000319545.12
methylthioribose-1-phosphate isomerase 1
chrX_+_57592011 3.80 ENST00000374888.3
zinc finger X-linked duplicated B
chr12_-_54984667 3.79 ENST00000524668.5
ENST00000533607.1
ENST00000449076.6
thymocyte expressed, positive selection associated 1
chr5_+_134526100 3.65 ENST00000395003.5
jade family PHD finger 2
chr10_+_94089034 3.60 ENST00000676102.1
ENST00000371385.8
phospholipase C epsilon 1
chr13_+_35476740 3.55 ENST00000537702.5
neurobeachin
chr1_-_7853054 3.51 ENST00000361696.10
urotensin 2
chr5_-_137736066 3.47 ENST00000309755.9
kelch like family member 3
chr9_+_33795551 3.46 ENST00000379405.4
serine protease 3
chr19_+_5681000 3.37 ENST00000581893.5
ENST00000411793.6
ENST00000301382.8
ENST00000581773.5
ENST00000339423.7
ENST00000423665.6
ENST00000583928.5
ENST00000342970.6
ENST00000422535.6
ENST00000581521.5
hydroxysteroid 11-beta dehydrogenase 1 like
chr5_-_126595185 3.37 ENST00000510111.6
ENST00000635851.1
ENST00000637964.1
ENST00000413020.6
ENST00000637782.1
ENST00000409134.8
ENST00000637272.1
ENST00000636879.1
ENST00000636743.1
ENST00000636886.1
ENST00000509270.2
aldehyde dehydrogenase 7 family member A1
chr6_+_101393699 3.35 ENST00000369134.9
ENST00000684068.1
ENST00000683903.1
ENST00000681975.1
glutamate ionotropic receptor kainate type subunit 2
chr17_-_15598797 3.34 ENST00000354433.7
CMT1A duplicated region transcript 1
chr16_-_66550112 3.25 ENST00000544898.6
ENST00000620035.5
ENST00000545043.6
thymidine kinase 2
chr7_+_94509793 3.06 ENST00000297273.9
CAS1 domain containing 1
chr5_-_134367144 3.05 ENST00000265334.9
cyclin dependent kinase like 3
chr17_-_75405486 2.98 ENST00000392562.5
growth factor receptor bound protein 2
chr12_-_101210232 2.98 ENST00000536262.3
solute carrier family 5 member 8
chr19_-_38878247 2.93 ENST00000591812.2
Ras and Rab interactor like
chr16_-_10942443 2.91 ENST00000570440.2
ENST00000331808.5
Dexi homolog
chrX_-_43973382 2.77 ENST00000642620.1
ENST00000647044.1
norrin cystine knot growth factor NDP
chrX_+_71223216 2.67 ENST00000361726.7
gap junction protein beta 1
chr11_-_70717994 2.65 ENST00000659264.1
SH3 and multiple ankyrin repeat domains 2
chr17_-_15598618 2.64 ENST00000583965.5
CMT1A duplicated region transcript 1
chr12_-_84912783 2.63 ENST00000680892.1
ENST00000266682.10
ENST00000680714.1
ENST00000552192.5
solute carrier family 6 member 15
chr16_+_29662923 2.63 ENST00000395389.2
sialophorin
chr12_+_124993633 2.57 ENST00000341446.9
ENST00000671775.2
BRI3 binding protein
chr12_+_8123899 2.56 ENST00000641376.1
C-type lectin domain family 4 member A
chr17_-_3292600 2.51 ENST00000615105.1
olfactory receptor family 3 subfamily A member 1
chr17_-_27893339 2.48 ENST00000460380.6
ENST00000379102.8
ENST00000508862.5
ENST00000582441.1
LYR motif containing 9
novel protein
chr1_-_110519175 2.38 ENST00000369771.4
potassium voltage-gated channel subfamily A member 10
chr9_-_6645712 2.37 ENST00000321612.8
glycine decarboxylase
chr1_-_100249815 2.35 ENST00000370131.3
ENST00000681617.1
ENST00000681780.1
ENST00000370132.8
dihydrolipoamide branched chain transacylase E2
chr13_+_91398613 2.35 ENST00000377067.9
glypican 5
chr6_+_151240368 2.35 ENST00000253332.5
A-kinase anchoring protein 12
chrX_+_15790446 2.31 ENST00000380308.7
ENST00000307771.8
zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
chr12_+_57216779 2.26 ENST00000349394.6
neurexophilin 4
chr16_-_67393486 2.22 ENST00000562206.1
ENST00000393957.7
ENST00000290942.9
tubulin polymerization promoting protein family member 3
chrX_+_54808359 2.18 ENST00000375058.5
ENST00000375060.5
MAGE family member D2
chr16_+_29663219 2.13 ENST00000436527.5
ENST00000360121.4
ENST00000652691.1
ENST00000449759.2
sialophorin
quinolinate phosphoribosyltransferase
chr2_-_60550900 2.12 ENST00000643222.1
ENST00000643459.1
ENST00000489516.7
BAF chromatin remodeling complex subunit BCL11A
chr8_-_40897814 2.12 ENST00000297737.11
ENST00000315769.11
zinc finger matrin-type 4
chr1_+_162632454 2.11 ENST00000367921.8
ENST00000367922.7
discoidin domain receptor tyrosine kinase 2
chr12_-_84912705 2.10 ENST00000679933.1
ENST00000680260.1
ENST00000551010.2
ENST00000679453.1
ENST00000681281.1
solute carrier family 6 member 15
chr5_-_126595237 2.09 ENST00000637206.1
ENST00000553117.5
aldehyde dehydrogenase 7 family member A1
chr6_+_13013513 2.07 ENST00000675203.1
phosphatase and actin regulator 1
chr22_+_35299800 2.07 ENST00000456128.5
ENST00000411850.5
ENST00000425375.5
ENST00000449058.7
target of myb1 membrane trafficking protein
chr17_+_70075215 2.04 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
potassium inwardly rectifying channel subfamily J member 16
chr1_+_156154371 2.04 ENST00000368282.1
semaphorin 4A
chr19_-_40226682 2.03 ENST00000430325.7
ENST00000599263.6
cyclin P
chr1_-_100895132 2.02 ENST00000535414.5
exostosin like glycosyltransferase 2
chr13_-_77919390 1.97 ENST00000475537.2
ENST00000646605.1
endothelin receptor type B
chr6_-_47042260 1.81 ENST00000371243.2
adhesion G protein-coupled receptor F1
chr1_+_3698027 1.80 ENST00000378290.4
tumor protein p73
chr19_+_15049469 1.79 ENST00000427043.4
caspase 14
chr22_-_38794111 1.78 ENST00000406622.5
ENST00000216068.9
ENST00000406199.3
Sad1 and UNC84 domain containing 2
dynein axonemal light chain 4
chr3_+_44874606 1.76 ENST00000296125.9
transglutaminase 4
chr17_+_28473278 1.73 ENST00000444914.7
solute carrier family 13 member 2
chrX_+_37780049 1.70 ENST00000378588.5
cytochrome b-245 beta chain
chr12_-_21774688 1.70 ENST00000240662.3
potassium inwardly rectifying channel subfamily J member 8
chr11_-_89063631 1.68 ENST00000455756.6
glutamate metabotropic receptor 5
chr1_-_112956063 1.68 ENST00000538576.5
ENST00000369626.8
ENST00000458229.6
solute carrier family 16 member 1
chr15_-_58014097 1.63 ENST00000559517.5
aldehyde dehydrogenase 1 family member A2
chr11_+_68460712 1.62 ENST00000528635.5
ENST00000533127.5
ENST00000529907.5
ENST00000529344.5
ENST00000534534.5
ENST00000524845.5
ENST00000393800.7
ENST00000265637.8
ENST00000524904.5
ENST00000393801.7
ENST00000265636.9
ENST00000529710.5
protein phosphatase 6 regulatory subunit 3
chr7_-_117323041 1.57 ENST00000491214.1
ENST00000265441.8
Wnt family member 2
chr22_-_50261543 1.55 ENST00000395778.3
ENST00000215659.13
mitogen-activated protein kinase 12
chrX_+_83508284 1.53 ENST00000644024.2
POU class 3 homeobox 4
chr1_-_3796478 1.43 ENST00000378251.3
leucine rich repeat containing 47
chr9_-_21368057 1.41 ENST00000449498.2
interferon alpha 13
chr11_-_2140967 1.38 ENST00000381389.5
insulin like growth factor 2
chr2_-_199458689 1.37 ENST00000443023.5
SATB homeobox 2
chr20_-_63537361 1.33 ENST00000217185.3
ENST00000542869.3
protein tyrosine kinase 6
chr21_+_31873010 1.32 ENST00000270112.7
hormonally up-regulated Neu-associated kinase
chr10_+_18400562 1.32 ENST00000377315.5
ENST00000650685.1
calcium voltage-gated channel auxiliary subunit beta 2
chr5_-_134367070 1.31 ENST00000521118.5
cyclin dependent kinase like 3
chr17_-_3595831 1.27 ENST00000399759.7
transient receptor potential cation channel subfamily V member 1
chr1_+_17308194 1.21 ENST00000375453.5
ENST00000375448.4
peptidyl arginine deiminase 4
chr7_-_101165558 1.19 ENST00000611537.1
ENST00000249330.3
VGF nerve growth factor inducible
chr14_+_24232921 1.17 ENST00000557854.5
ENST00000399440.7
ENST00000559104.5
ENST00000456667.7
guanosine monophosphate reductase 2
chr7_-_44141285 1.16 ENST00000458240.5
ENST00000223364.7
myosin light chain 7
chr11_+_3645105 1.14 ENST00000250693.2
ADP-ribosyltransferase 1
chr7_-_44141074 1.13 ENST00000457314.5
ENST00000447951.1
ENST00000431007.1
myosin light chain 7
chr9_-_5304713 1.10 ENST00000381627.4
relaxin 2
chr1_-_23217482 1.09 ENST00000374619.2
5-hydroxytryptamine receptor 1D
chr1_+_18630839 1.03 ENST00000420770.7
paired box 7
chr14_+_24310134 1.02 ENST00000533293.2
ENST00000543919.1
leukotriene B4 receptor 2
chrX_+_15507302 1.01 ENST00000342014.6
BMX non-receptor tyrosine kinase
chr9_-_113221243 1.01 ENST00000238256.8
FKBP prolyl isomerase family member 15
chrX_+_54808334 1.00 ENST00000218439.8
MAGE family member D2
chr16_+_71626175 0.99 ENST00000268485.8
ENST00000565261.1
ENST00000299952.4
MARVEL domain containing 3
chrY_-_13986473 0.97 ENST00000250825.5
variable charge Y-linked
chr16_+_30069539 0.96 ENST00000565355.1
aldolase, fructose-bisphosphate A
chr17_-_44199834 0.93 ENST00000587097.6
ataxin 7 like 3
chr1_+_36156096 0.93 ENST00000474796.2
ENST00000373150.8
ENST00000373151.6
MAP7 domain containing 1
chr11_-_101583503 0.92 ENST00000348423.8
ENST00000360497.4
ENST00000532133.5
transient receptor potential cation channel subfamily C member 6
chrX_+_48597482 0.92 ENST00000218056.9
ENST00000376729.10
WD repeat domain 13
chr10_-_103855406 0.89 ENST00000355946.6
ENST00000369774.8
SH3 and PX domains 2A
chr16_+_16379055 0.87 ENST00000530217.2
nuclear pore complex interacting protein family member A7
chr13_+_29428603 0.87 ENST00000380808.6
microtubule associated scaffold protein 2
chr13_-_20161038 0.84 ENST00000241125.4
gap junction protein alpha 3
chr19_-_42423100 0.84 ENST00000597001.1
lipase E, hormone sensitive type
chr12_-_96400365 0.83 ENST00000261211.8
ENST00000543119.6
cyclin dependent kinase 17
chr1_-_24143112 0.82 ENST00000270800.2
interleukin 22 receptor subunit alpha 1
chr16_-_28471175 0.79 ENST00000435324.3
nuclear pore complex interacting protein family member B7
chr17_-_46818680 0.74 ENST00000225512.6
Wnt family member 3
chr7_+_139829242 0.70 ENST00000455353.6
ENST00000458722.6
ENST00000448866.7
ENST00000411653.6
thromboxane A synthase 1
chr19_+_47019800 0.69 ENST00000602212.6
ENST00000602189.5
neuronal PAS domain protein 1
chr19_-_49451793 0.69 ENST00000262265.10
PIH1 domain containing 1
chr1_+_43300971 0.69 ENST00000372476.8
ENST00000538015.1
tyrosine kinase with immunoglobulin like and EGF like domains 1
chr16_-_55833186 0.68 ENST00000361503.8
ENST00000422046.6
carboxylesterase 1
chr8_-_96235533 0.68 ENST00000518406.5
ENST00000287022.10
ENST00000523920.1
ubiquinol-cytochrome c reductase binding protein
chr6_+_25754699 0.65 ENST00000439485.6
ENST00000377905.9
solute carrier family 17 member 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.1 84.5 GO:0060313 negative regulation of blood vessel remodeling(GO:0060313)
13.6 67.9 GO:1902847 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
8.5 34.2 GO:1904021 regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021)
7.2 21.5 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
7.0 28.2 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
4.8 14.5 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
3.7 11.1 GO:0030185 nitric oxide transport(GO:0030185)
3.6 17.9 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
3.2 25.9 GO:0001887 selenium compound metabolic process(GO:0001887)
3.1 9.2 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
2.9 17.3 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
2.7 13.6 GO:0030070 insulin processing(GO:0030070)
2.5 10.2 GO:1990928 response to amino acid starvation(GO:1990928)
2.5 25.1 GO:0048680 positive regulation of axon regeneration(GO:0048680) negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
2.5 10.0 GO:0005986 sucrose biosynthetic process(GO:0005986)
2.2 22.0 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.0 10.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.9 20.8 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
1.8 5.5 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
1.8 3.5 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
1.6 16.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
1.6 4.8 GO:0002884 negative regulation of hypersensitivity(GO:0002884)
1.5 21.8 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
1.4 5.6 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) regulation of intracellular calcium activated chloride channel activity(GO:1902938)
1.3 12.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
1.2 14.7 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.0 7.7 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
1.0 6.7 GO:0070294 renal sodium ion absorption(GO:0070294)
0.9 9.0 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.9 9.9 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.8 4.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.7 33.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.7 8.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.7 6.7 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.6 3.8 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.6 3.6 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.6 8.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.6 5.2 GO:0042118 endothelial cell activation(GO:0042118)
0.6 1.7 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.6 7.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.6 2.8 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 3.2 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.5 2.1 GO:1904799 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.5 2.4 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.5 4.7 GO:0015820 leucine transport(GO:0015820)
0.4 2.0 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.4 1.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.4 2.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.3 1.0 GO:0014813 skeletal muscle satellite cell commitment(GO:0014813)
0.3 4.4 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.3 16.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.3 1.3 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.3 3.8 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.3 1.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.3 0.9 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.3 1.4 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.3 7.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 2.3 GO:1904954 canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.3 5.8 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.2 2.7 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.2 1.7 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.2 3.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 1.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 0.7 GO:1903939 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.2 28.3 GO:0007368 determination of left/right symmetry(GO:0007368)
0.2 0.6 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.2 12.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.2 1.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 1.6 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 3.0 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.2 7.8 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.2 7.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 3.0 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2 9.7 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.8 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.4 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 1.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.7 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 1.5 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1 4.4 GO:0097484 dendrite extension(GO:0097484)
0.1 1.1 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.1 0.5 GO:0086100 enteric smooth muscle cell differentiation(GO:0035645) endothelin receptor signaling pathway(GO:0086100)
0.1 11.2 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.1 4.3 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 4.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 1.0 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 5.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 5.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 1.0 GO:1902414 protein localization to cell junction(GO:1902414)
0.1 2.6 GO:0060292 long term synaptic depression(GO:0060292)
0.1 0.9 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 2.0 GO:0010107 potassium ion import(GO:0010107)
0.1 0.5 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 4.5 GO:0006400 tRNA modification(GO:0006400)
0.1 1.2 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 2.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 0.7 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 1.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.3 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 1.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.5 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 1.0 GO:0002021 response to dietary excess(GO:0002021)
0.1 2.0 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 0.7 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.1 0.1 GO:1903626 apoptotic process involved in embryonic digit morphogenesis(GO:1902263) positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.1 0.5 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 15.2 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.1 0.4 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.9 GO:0006828 manganese ion transport(GO:0006828)
0.0 1.7 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.2 GO:0043101 purine nucleobase metabolic process(GO:0006144) purine-containing compound salvage(GO:0043101)
0.0 0.7 GO:0042711 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0 0.1 GO:0034137 regulation of toll-like receptor 2 signaling pathway(GO:0034135) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0042377 pressure natriuresis(GO:0003095) menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.0 0.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.5 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 3.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 2.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.6 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 2.3 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 2.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 7.2 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.0 1.1 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 1.4 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.5 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.3 GO:0051873 innate immune response in mucosa(GO:0002227) killing by host of symbiont cells(GO:0051873)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.1 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 1.7 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 0.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 2.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.7 GO:0045026 plasma membrane fusion(GO:0045026)
0.0 0.1 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 1.8 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.2 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.3 GO:0050873 brown fat cell differentiation(GO:0050873)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 67.9 GO:0097418 neurofibrillary tangle(GO:0097418)
2.8 11.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
2.5 10.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
2.2 17.9 GO:0045179 apical cortex(GO:0045179)
1.3 25.9 GO:0031089 platelet dense granule lumen(GO:0031089)
1.2 4.7 GO:0071546 pi-body(GO:0071546)
1.1 12.1 GO:0005955 calcineurin complex(GO:0005955)
1.1 6.3 GO:0032584 growth cone membrane(GO:0032584)
1.0 73.1 GO:0005771 multivesicular body(GO:0005771)
0.8 5.5 GO:0033391 chromatoid body(GO:0033391)
0.6 2.4 GO:0005960 glycine cleavage complex(GO:0005960)
0.6 7.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.5 1.4 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.5 2.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.5 2.3 GO:0089701 U2AF(GO:0089701)
0.4 54.5 GO:0042734 presynaptic membrane(GO:0042734)
0.4 26.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.4 3.0 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.4 22.1 GO:0031430 M band(GO:0031430)
0.3 91.1 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 29.8 GO:0005604 basement membrane(GO:0005604)
0.2 42.2 GO:0030426 growth cone(GO:0030426)
0.2 1.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 18.4 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 1.2 GO:1902560 GMP reductase complex(GO:1902560)
0.2 2.2 GO:0097427 microtubule bundle(GO:0097427)
0.2 11.1 GO:0043195 terminal bouton(GO:0043195)
0.2 1.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 0.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 16.6 GO:0005882 intermediate filament(GO:0005882)
0.1 2.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 4.4 GO:0099738 cell cortex region(GO:0099738)
0.1 13.6 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 13.0 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 40.9 GO:0030424 axon(GO:0030424)
0.1 1.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 5.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 5.7 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 3.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.3 GO:0031672 A band(GO:0031672)
0.1 0.7 GO:0070761 pre-snoRNP complex(GO:0070761)
0.1 3.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 22.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 4.3 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.7 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 2.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.5 GO:0030914 STAGA complex(GO:0030914)
0.0 5.3 GO:0001726 ruffle(GO:0001726)
0.0 1.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 1.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.8 GO:0005901 caveola(GO:0005901)
0.0 5.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 4.2 GO:0005938 cell cortex(GO:0005938)
0.0 1.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.1 GO:0071682 endocytic vesicle lumen(GO:0071682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.4 34.2 GO:0031687 A2A adenosine receptor binding(GO:0031687)
5.4 21.5 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
4.2 25.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
3.0 67.9 GO:0051787 misfolded protein binding(GO:0051787)
2.8 28.2 GO:0030911 TPR domain binding(GO:0030911)
2.5 10.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
2.5 10.0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
2.2 25.9 GO:0008430 selenium binding(GO:0008430)
1.6 11.1 GO:0030492 hemoglobin binding(GO:0030492)
1.5 12.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.3 24.2 GO:0008179 adenylate cyclase binding(GO:0008179)
1.1 17.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.9 4.7 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.9 5.6 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.9 76.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.9 20.9 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.9 20.8 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.8 5.3 GO:0005499 vitamin D binding(GO:0005499)
0.7 14.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.7 8.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.7 2.0 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.7 9.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.6 9.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.6 2.3 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.6 1.7 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.6 1.7 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.5 3.2 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.4 15.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.4 2.6 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.4 3.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 22.0 GO:0030507 spectrin binding(GO:0030507)
0.4 2.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 3.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 2.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.3 1.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.3 7.8 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.3 1.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 0.8 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.3 4.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.3 5.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 7.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.3 4.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 3.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 1.3 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.3 10.2 GO:0000049 tRNA binding(GO:0000049)
0.2 1.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 0.7 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.2 1.2 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.2 3.5 GO:0005243 gap junction channel activity(GO:0005243)
0.2 1.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.2 0.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 4.8 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 0.8 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 6.7 GO:0001848 complement binding(GO:0001848)
0.2 2.4 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.2 26.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 5.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 29.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 5.1 GO:0005109 frizzled binding(GO:0005109)
0.2 4.9 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 4.7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.6 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 1.7 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 2.4 GO:0016594 glycine binding(GO:0016594)
0.1 1.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 0.7 GO:0004771 sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 1.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 2.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.5 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
0.1 0.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 2.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 11.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.5 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 5.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.5 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.8 GO:0043495 protein anchor(GO:0043495)
0.1 0.7 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1 1.1 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 9.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 6.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.7 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 2.8 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 5.5 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 1.2 GO:0004707 MAP kinase activity(GO:0004707)
0.1 27.8 GO:0015631 tubulin binding(GO:0015631)
0.1 1.0 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 0.6 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 12.0 GO:0042393 histone binding(GO:0042393)
0.1 0.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 7.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.6 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.1 GO:0097259 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 3.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 2.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.0 3.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.0 2.1 GO:0030276 clathrin binding(GO:0030276)
0.0 1.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 6.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 10.0 GO:0008270 zinc ion binding(GO:0008270)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 21.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.7 34.4 PID RAS PATHWAY Regulation of Ras family activation
0.5 67.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.4 14.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4 25.6 ST ADRENERGIC Adrenergic Pathway
0.3 87.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 13.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 14.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 10.2 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.2 11.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 4.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 1.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.9 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 3.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 64.4 REACTOME AMYLOIDS Genes involved in Amyloids
1.4 16.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.8 17.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.6 26.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.6 13.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 75.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 17.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.3 8.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 21.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 7.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.2 3.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 4.4 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 3.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 3.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 11.4 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 3.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 10.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 4.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 7.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.8 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 4.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 0.9 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 4.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 5.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.7 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 1.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 3.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.3 REACTOME DEFENSINS Genes involved in Defensins
0.1 1.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 2.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 4.4 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 6.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 3.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 6.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 3.6 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 2.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport