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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXA10_HOXB9
Z-value: 1.42
Motif logo
Transcription factors associated with HOXA10_HOXB9
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HOXA10
|
ENSG00000253293.5 | HOXA10 |
|
HOXB9
|
ENSG00000170689.10 | HOXB9 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB9 | hg38_v1_chr17_-_48626325_48626379 | -0.27 | 5.0e-05 | Click! |
| HOXA10 | hg38_v1_chr7_-_27174274_27174335, hg38_v1_chr7_-_27174253_27174267 | -0.13 | 5.0e-02 | Click! |
Activity profile of HOXA10_HOXB9 motif
Sorted Z-values of HOXA10_HOXB9 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA10_HOXB9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 6.3 | GO:0061011 | hepatic duct development(GO:0061011) |
| 1.7 | 10.3 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 1.6 | 9.8 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 1.5 | 15.2 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 1.2 | 3.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 1.1 | 6.7 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.1 | 3.2 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.9 | 2.6 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
| 0.9 | 2.6 | GO:0034092 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.5 | 3.8 | GO:0090170 | regulation of Golgi inheritance(GO:0090170) |
| 0.5 | 2.1 | GO:0071418 | cellular response to amine stimulus(GO:0071418) |
| 0.5 | 1.5 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.5 | 4.3 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 0.4 | 1.3 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
| 0.4 | 9.5 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.4 | 2.1 | GO:1903936 | cellular response to sodium arsenite(GO:1903936) |
| 0.4 | 4.4 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.4 | 7.9 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.4 | 5.7 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.4 | 1.1 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.4 | 4.1 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.3 | 2.8 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.3 | 4.1 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.3 | 5.8 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.3 | 2.0 | GO:2000470 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 0.3 | 1.0 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 0.3 | 1.3 | GO:0034628 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 0.3 | 1.0 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.3 | 1.3 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.3 | 1.9 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.3 | 1.9 | GO:0038016 | insulin receptor internalization(GO:0038016) |
| 0.3 | 3.1 | GO:0003402 | planar cell polarity pathway involved in axis elongation(GO:0003402) |
| 0.3 | 3.7 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.3 | 0.9 | GO:1901388 | regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389) |
| 0.3 | 0.8 | GO:0021779 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.3 | 2.2 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.3 | 2.5 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.3 | 2.3 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.2 | 4.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.2 | 0.7 | GO:0060661 | submandibular salivary gland formation(GO:0060661) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 0.2 | 1.8 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.2 | 1.1 | GO:0033058 | directional locomotion(GO:0033058) |
| 0.2 | 3.8 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.2 | 2.4 | GO:1903358 | Golgi to lysosome transport(GO:0090160) regulation of Golgi organization(GO:1903358) |
| 0.2 | 2.5 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.2 | 0.5 | GO:0018282 | metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) |
| 0.2 | 2.5 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.2 | 0.7 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.2 | 0.8 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.2 | 1.2 | GO:0009441 | glycolate metabolic process(GO:0009441) |
| 0.2 | 10.1 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 1.6 | GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine(GO:0008612) |
| 0.1 | 2.4 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103) |
| 0.1 | 0.5 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.1 | 0.8 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 0.7 | GO:0032383 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 0.1 | 0.8 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.1 | 0.6 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 1.1 | GO:0097267 | omega-hydroxylase P450 pathway(GO:0097267) |
| 0.1 | 0.5 | GO:0010841 | positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) |
| 0.1 | 0.8 | GO:0033029 | neutrophil apoptotic process(GO:0001781) regulation of neutrophil apoptotic process(GO:0033029) |
| 0.1 | 0.4 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 0.1 | 1.1 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.1 | 2.6 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) positive regulation of synapse maturation(GO:0090129) |
| 0.1 | 5.6 | GO:0061512 | protein localization to cilium(GO:0061512) |
| 0.1 | 0.8 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
| 0.1 | 0.3 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.1 | 0.3 | GO:0070857 | regulation of bile acid biosynthetic process(GO:0070857) |
| 0.1 | 1.3 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.1 | 1.3 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 1.1 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.1 | 2.2 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 2.1 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.1 | 0.3 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.1 | 4.7 | GO:0050850 | positive regulation of calcium-mediated signaling(GO:0050850) |
| 0.1 | 3.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 0.4 | GO:2000320 | T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.1 | 1.1 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.3 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.1 | 1.0 | GO:0031573 | DNA replication checkpoint(GO:0000076) intra-S DNA damage checkpoint(GO:0031573) |
| 0.1 | 1.2 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.1 | 2.3 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.1 | 2.6 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.1 | 1.6 | GO:0032402 | melanosome transport(GO:0032402) |
| 0.1 | 0.5 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.1 | 1.3 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.0 | 3.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 4.0 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.9 | GO:0086069 | bundle of His cell to Purkinje myocyte communication(GO:0086069) |
| 0.0 | 0.2 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 0.0 | 0.2 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.0 | 0.6 | GO:1904322 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.0 | 0.7 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.6 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.0 | 3.1 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.0 | 0.1 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 0.0 | 2.5 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 1.1 | GO:0008089 | anterograde axonal transport(GO:0008089) |
| 0.0 | 1.6 | GO:0014072 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.0 | 2.4 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.0 | 3.0 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 0.1 | GO:0050720 | interleukin-1 beta biosynthetic process(GO:0050720) |
| 0.0 | 0.6 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 0.7 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.0 | 0.4 | GO:0098534 | centriole replication(GO:0007099) centriole assembly(GO:0098534) |
| 0.0 | 0.2 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 0.0 | 1.8 | GO:0050771 | negative regulation of axonogenesis(GO:0050771) |
| 0.0 | 1.6 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 0.1 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.0 | 1.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 1.3 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 0.3 | GO:0010623 | programmed cell death involved in cell development(GO:0010623) |
| 0.0 | 1.6 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.0 | 1.2 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.2 | GO:0007379 | segment specification(GO:0007379) |
| 0.0 | 0.3 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.0 | 0.1 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.0 | 0.4 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 3.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.9 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 0.8 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 1.0 | GO:1902017 | regulation of cilium assembly(GO:1902017) |
| 0.0 | 1.9 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 0.8 | GO:1901224 | positive regulation of NIK/NF-kappaB signaling(GO:1901224) |
| 0.0 | 2.4 | GO:0010389 | regulation of G2/M transition of mitotic cell cycle(GO:0010389) |
| 0.0 | 0.5 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.0 | 0.3 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 1.4 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 1.6 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 0.1 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 0.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.7 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 1.1 | 3.2 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.9 | 2.6 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.8 | 10.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.8 | 7.6 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.7 | 3.6 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.6 | 2.6 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 0.6 | 2.4 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.5 | 9.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.5 | 4.1 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.4 | 2.9 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.4 | 2.5 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.4 | 2.4 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.3 | 6.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 0.9 | GO:1990917 | sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917) |
| 0.3 | 2.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.3 | 0.8 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 0.2 | 3.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 1.5 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.2 | 2.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 2.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.2 | 3.4 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.1 | 1.8 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex III(GO:0045275) |
| 0.1 | 0.8 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
| 0.1 | 0.7 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 3.1 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 1.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 2.3 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.1 | 1.0 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.1 | 3.7 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 3.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 0.7 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.1 | 1.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 1.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 1.1 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.3 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.1 | 1.3 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.1 | 0.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 3.4 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 4.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.2 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 9.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 4.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 2.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.5 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 2.5 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 2.4 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 2.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.9 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 1.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 1.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 2.2 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 12.4 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 0.4 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 1.2 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 4.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 1.4 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 6.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.6 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 2.2 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 1.6 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.3 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 1.0 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.9 | 2.6 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.8 | 7.6 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.7 | 2.2 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.7 | 3.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.5 | 2.1 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.4 | 1.3 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.4 | 1.7 | GO:0061752 | telomeric repeat-containing RNA binding(GO:0061752) |
| 0.4 | 6.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.4 | 1.2 | GO:0052854 | (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854) |
| 0.4 | 10.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.3 | 2.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 2.0 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.3 | 9.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.3 | 4.0 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.3 | 6.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.3 | 1.3 | GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) |
| 0.3 | 0.9 | GO:0002135 | CTP binding(GO:0002135) |
| 0.3 | 2.4 | GO:0046935 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.3 | 1.3 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.2 | 1.0 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.2 | 1.9 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 0.2 | 6.7 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.2 | 0.7 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.2 | 1.8 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 0.7 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.2 | 1.1 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.2 | 0.7 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.2 | 0.9 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.2 | 1.3 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.2 | 0.8 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.2 | 4.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 0.8 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 0.2 | 4.4 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.2 | 2.8 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 2.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.2 | 1.2 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.2 | 3.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 0.6 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 1.3 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 1.3 | GO:0005549 | odorant binding(GO:0005549) |
| 0.1 | 0.8 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 5.4 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.1 | 2.7 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 1.7 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.1 | 0.6 | GO:0051998 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.1 | 0.8 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.1 | 1.1 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 4.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 0.7 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 1.8 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 2.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 6.1 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 1.3 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 0.9 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.1 | 0.8 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 0.2 | GO:0003826 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
| 0.1 | 1.3 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 1.3 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 0.4 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 0.3 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.1 | 4.7 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 1.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.5 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 1.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.6 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.1 | 1.1 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 1.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.3 | GO:0051373 | protein phosphatase 2B binding(GO:0030346) FATZ binding(GO:0051373) |
| 0.0 | 0.5 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.0 | 1.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 1.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 8.4 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 0.7 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 1.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.2 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 0.6 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 5.6 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 0.3 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577) |
| 0.0 | 3.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 3.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.5 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.0 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.0 | 1.6 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 1.7 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.0 | 1.6 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 1.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.1 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.0 | 1.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.3 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 0.6 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 0.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 13.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 3.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 7.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 1.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 2.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 7.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 2.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 0.8 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 9.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 0.7 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.1 | 5.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 2.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.1 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 1.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 4.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 3.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.8 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 2.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.4 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.0 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.8 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 0.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 2.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.3 | 3.8 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.2 | 4.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 7.0 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 3.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 14.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 5.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.2 | 10.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 5.5 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 2.1 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 1.2 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.1 | 2.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.3 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |
| 0.1 | 2.6 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 5.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.8 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 1.3 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 1.1 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 1.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 1.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 0.9 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 2.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.7 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 1.4 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 3.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.6 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 3.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.8 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 2.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.1 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 1.0 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 4.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.6 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.6 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 1.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.5 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.0 | 0.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 1.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.8 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 0.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.4 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |