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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXA2_HOXB1

Z-value: 2.07

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol Gene ID Gene Info
HOXA2
ENSG00000105996.7 HOXA2
HOXB1
ENSG00000120094.9 HOXB1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB1hg38_v1_chr17_-_48530910_485310260.483.3e-14Click!
HOXA2hg38_v1_chr7_-_27102669_271026910.429.8e-11Click!

Activity profile of HOXA2_HOXB1 motif

Sorted Z-values of HOXA2_HOXB1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_151239951 19.81 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chrX_-_13817346 16.48 ENST00000356942.9
GPM6B
glycoprotein M6B
chr11_-_111911759 16.30 ENST00000650687.2
CRYAB
crystallin alpha B
chr6_+_151240368 16.04 ENST00000253332.5
AKAP12
A-kinase anchoring protein 12
chr14_-_21048431 15.86 ENST00000555026.5
NDRG2
NDRG family member 2
chr4_-_89836213 14.98 ENST00000618500.4
ENST00000508895.5
SNCA
synuclein alpha
chrX_-_13817027 12.26 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
GPM6B
glycoprotein M6B
chr16_+_7510102 10.90 ENST00000682918.1
ENST00000683326.1
ENST00000570626.2
RBFOX1
RNA binding fox-1 homolog 1
chr4_-_89835617 10.38 ENST00000611107.1
ENST00000345009.8
ENST00000505199.5
ENST00000502987.5
SNCA
synuclein alpha
chr7_+_86643902 10.10 ENST00000361669.7
GRM3
glutamate metabotropic receptor 3
chr3_+_150546765 9.03 ENST00000406576.7
ENST00000460851.6
ENST00000482093.5
ENST00000273435.9
EIF2A
eukaryotic translation initiation factor 2A
chr10_-_121596117 9.01 ENST00000351936.11
FGFR2
fibroblast growth factor receptor 2
chr12_-_14885845 8.37 ENST00000539261.6
ENST00000228938.5
MGP
matrix Gla protein
chr12_+_21526287 8.00 ENST00000256969.7
SPX
spexin hormone
chr16_+_15502266 7.98 ENST00000452191.6
BMERB1
bMERB domain containing 1
chr20_+_36154630 7.84 ENST00000338074.7
ENST00000636016.2
ENST00000373945.5
EPB41L1
erythrocyte membrane protein band 4.1 like 1
chr3_-_187670385 7.70 ENST00000287641.4
SST
somatostatin
chr18_+_59220149 7.51 ENST00000256857.7
ENST00000529320.2
ENST00000420468.6
GRP
gastrin releasing peptide
chr19_-_49441508 6.43 ENST00000221485.8
SLC17A7
solute carrier family 17 member 7
chrX_+_83508284 6.06 ENST00000644024.2
POU3F4
POU class 3 homeobox 4
chr3_+_189789672 6.00 ENST00000434928.5
TP63
tumor protein p63
chr17_-_39197652 5.79 ENST00000394303.8
CACNB1
calcium voltage-gated channel auxiliary subunit beta 1
chr12_+_101594849 5.68 ENST00000547405.5
ENST00000452455.6
ENST00000392934.7
ENST00000547509.5
ENST00000361685.6
ENST00000549145.5
ENST00000361466.7
ENST00000553190.5
ENST00000545503.6
ENST00000536007.5
ENST00000541119.5
ENST00000551300.5
ENST00000550270.1
MYBPC1
myosin binding protein C1
chr8_+_103140692 5.64 ENST00000438105.2
ENST00000309982.10
ENST00000297574.6
BAALC
BAALC binder of MAP3K1 and KLF4
chr5_-_126595185 5.21 ENST00000510111.6
ENST00000635851.1
ENST00000637964.1
ENST00000413020.6
ENST00000637782.1
ENST00000409134.8
ENST00000637272.1
ENST00000636879.1
ENST00000636743.1
ENST00000636886.1
ENST00000509270.2
ALDH7A1
aldehyde dehydrogenase 7 family member A1
chr8_-_142879820 5.16 ENST00000377675.3
ENST00000517471.5
ENST00000292427.10
CYP11B1
cytochrome P450 family 11 subfamily B member 1
chr12_+_57216779 4.92 ENST00000349394.6
NXPH4
neurexophilin 4
chr8_+_142449430 4.77 ENST00000643448.1
ENST00000517894.5
ADGRB1
adhesion G protein-coupled receptor B1
chr1_-_66924791 4.72 ENST00000371023.7
ENST00000371022.3
ENST00000371026.8
DNAI4
dynein axonemal intermediate chain 4
chr17_-_39197696 4.66 ENST00000394310.7
ENST00000622445.4
ENST00000344140.5
CACNB1
calcium voltage-gated channel auxiliary subunit beta 1
chr19_-_12887188 4.48 ENST00000264834.6
KLF1
Kruppel like factor 1
chr7_-_126533850 4.27 ENST00000444921.3
GRM8
glutamate metabotropic receptor 8
chrX_+_70062457 4.16 ENST00000338352.3
OTUD6A
OTU deubiquitinase 6A
chr8_-_142917843 4.14 ENST00000323110.2
CYP11B2
cytochrome P450 family 11 subfamily B member 2
chr19_+_37506931 4.06 ENST00000627814.3
ENST00000587143.5
ZNF793
zinc finger protein 793
chr10_-_103855406 3.88 ENST00000355946.6
ENST00000369774.8
SH3PXD2A
SH3 and PX domains 2A
chr2_-_44361555 3.84 ENST00000409957.5
PREPL
prolyl endopeptidase like
chr6_+_68635273 3.84 ENST00000370598.6
ADGRB3
adhesion G protein-coupled receptor B3
chr10_+_94089067 3.78 ENST00000371375.1
ENST00000675218.1
PLCE1
phospholipase C epsilon 1
chr10_+_94089034 3.60 ENST00000676102.1
ENST00000371385.8
PLCE1
phospholipase C epsilon 1
chr2_+_68734861 3.58 ENST00000467265.5
ARHGAP25
Rho GTPase activating protein 25
chr11_+_57597563 3.52 ENST00000619430.2
ENST00000457869.1
ENST00000340687.10
ENST00000278407.9
ENST00000378323.8
ENST00000378324.6
ENST00000403558.1
SERPING1
serpin family G member 1
chr6_-_32128191 3.44 ENST00000453203.2
ENST00000375203.8
ENST00000375201.8
ATF6B
activating transcription factor 6 beta
chr17_-_48530910 3.30 ENST00000577092.1
ENST00000239174.7
HOXB1
homeobox B1
chr16_-_49856105 3.27 ENST00000563137.7
ZNF423
zinc finger protein 423
chrX_+_41724174 3.15 ENST00000302548.5
GPR82
G protein-coupled receptor 82
chr3_+_156142962 3.01 ENST00000471742.5
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr13_-_77919390 2.96 ENST00000475537.2
ENST00000646605.1
EDNRB
endothelin receptor type B
chr12_-_57742120 2.94 ENST00000257897.7
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chrX_+_77447387 2.86 ENST00000439435.3
FGF16
fibroblast growth factor 16
chr1_-_223363337 2.85 ENST00000608996.5
SUSD4
sushi domain containing 4
chr11_-_2140967 2.75 ENST00000381389.5
IGF2
insulin like growth factor 2
chrX_-_66033664 2.73 ENST00000427538.5
VSIG4
V-set and immunoglobulin domain containing 4
chr12_-_48999363 2.68 ENST00000421952.3
DDN
dendrin
chr19_+_44141547 2.58 ENST00000426739.7
ENST00000592437.5
ZNF234
zinc finger protein 234
chr12_+_7130341 2.55 ENST00000266546.11
CLSTN3
calsyntenin 3
chr2_-_212124901 2.52 ENST00000402597.6
ERBB4
erb-b2 receptor tyrosine kinase 4
chr10_+_18400562 2.50 ENST00000377315.5
ENST00000650685.1
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr5_-_126595237 2.47 ENST00000637206.1
ENST00000553117.5
ALDH7A1
aldehyde dehydrogenase 7 family member A1
chrX_-_47650488 2.46 ENST00000247161.7
ENST00000376983.8
ENST00000343894.8
ELK1
ETS transcription factor ELK1
chr11_+_26188836 2.43 ENST00000672621.1
ANO3
anoctamin 3
chr7_-_27130733 2.41 ENST00000428284.2
ENST00000360046.10
ENST00000610970.1
HOXA4
homeobox A4
chr7_-_13989891 2.39 ENST00000405218.6
ETV1
ETS variant transcription factor 1
chr8_+_23528947 2.36 ENST00000519973.6
SLC25A37
solute carrier family 25 member 37
chr6_+_32038382 2.33 ENST00000478281.5
ENST00000471671.4
ENST00000435122.3
ENST00000644719.2
CYP21A2
cytochrome P450 family 21 subfamily A member 2
chr2_-_152098810 2.22 ENST00000636442.1
ENST00000638005.1
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr9_-_70414657 2.06 ENST00000377126.4
KLF9
Kruppel like factor 9
chrX_+_96684801 2.02 ENST00000324765.13
DIAPH2
diaphanous related formin 2
chr17_+_16381083 2.01 ENST00000535788.1
ENST00000302182.8
UBB
ubiquitin B
chr2_-_153478753 1.97 ENST00000325926.4
RPRM
reprimo, TP53 dependent G2 arrest mediator homolog
chr7_+_80135694 1.95 ENST00000457358.7
GNAI1
G protein subunit alpha i1
chr13_-_77919459 1.88 ENST00000643890.1
EDNRB
endothelin receptor type B
chr9_-_124507382 1.84 ENST00000373588.9
ENST00000620110.4
NR5A1
nuclear receptor subfamily 5 group A member 1
chr15_-_74209019 1.82 ENST00000323940.9
STRA6
signaling receptor and transporter of retinol STRA6
chr10_-_99235783 1.78 ENST00000370546.5
ENST00000614306.1
HPSE2
heparanase 2 (inactive)
chr9_+_26947039 1.73 ENST00000519968.5
ENST00000433700.5
IFT74
intraflagellar transport 74
chr17_+_60677822 1.63 ENST00000407086.8
ENST00000589222.5
ENST00000626960.2
ENST00000390652.9
BCAS3
BCAS3 microtubule associated cell migration factor
chr10_+_122560679 1.62 ENST00000657942.1
DMBT1
deleted in malignant brain tumors 1
chr12_+_56007484 1.62 ENST00000262032.9
IKZF4
IKAROS family zinc finger 4
chr1_-_109041986 1.59 ENST00000400794.7
ENST00000528747.1
ENST00000361054.7
WDR47
WD repeat domain 47
chr10_+_122560639 1.58 ENST00000344338.7
ENST00000330163.8
ENST00000652446.2
ENST00000666315.1
ENST00000368955.7
ENST00000368909.7
ENST00000368956.6
ENST00000619379.1
DMBT1
deleted in malignant brain tumors 1
chr18_+_21363593 1.55 ENST00000580732.6
GREB1L
GREB1 like retinoic acid receptor coactivator
chr10_+_35175586 1.52 ENST00000494479.5
ENST00000463314.5
ENST00000342105.7
ENST00000495301.1
CREM
cAMP responsive element modulator
chr17_+_39668447 1.47 ENST00000269582.3
ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr12_+_57089094 1.46 ENST00000342556.6
ENST00000300131.8
NAB2
NGFI-A binding protein 2
chr15_-_74208969 1.45 ENST00000423167.6
ENST00000432245.6
STRA6
signaling receptor and transporter of retinol STRA6
chr11_+_68460712 1.38 ENST00000528635.5
ENST00000533127.5
ENST00000529907.5
ENST00000529344.5
ENST00000534534.5
ENST00000524845.5
ENST00000393800.7
ENST00000265637.8
ENST00000524904.5
ENST00000393801.7
ENST00000265636.9
ENST00000529710.5
PPP6R3
protein phosphatase 6 regulatory subunit 3
chr10_+_122560751 1.32 ENST00000338354.10
ENST00000664692.1
ENST00000653442.1
ENST00000664974.1
DMBT1
deleted in malignant brain tumors 1
chr20_+_36214373 1.32 ENST00000432603.1
EPB41L1
erythrocyte membrane protein band 4.1 like 1
chr16_-_67393486 1.30 ENST00000562206.1
ENST00000393957.7
ENST00000290942.9
TPPP3
tubulin polymerization promoting protein family member 3
chr10_-_99235846 1.20 ENST00000370552.8
ENST00000370549.5
ENST00000628193.2
HPSE2
heparanase 2 (inactive)
chr14_+_22516273 1.18 ENST00000390510.1
TRAJ27
T cell receptor alpha joining 27
chr7_-_13989658 1.10 ENST00000430479.6
ENST00000433547.1
ENST00000405192.6
ETV1
ETS variant transcription factor 1
chr10_+_49988318 1.05 ENST00000374056.10
ENST00000679810.1
AGAP6
ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
chr7_-_27095972 1.04 ENST00000355633.5
ENST00000643460.2
HOXA1
homeobox A1
chr10_-_77637444 1.01 ENST00000639205.1
ENST00000639498.1
ENST00000372408.7
ENST00000372403.9
ENST00000640626.1
ENST00000404857.6
ENST00000638252.1
ENST00000640029.1
ENST00000640934.1
ENST00000639823.1
ENST00000372437.6
ENST00000639344.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr13_+_35476740 1.01 ENST00000537702.5
NBEA
neurobeachin
chr10_-_77637789 1.00 ENST00000481070.1
ENST00000640969.1
ENST00000286628.14
ENST00000638991.1
ENST00000639913.1
ENST00000480683.2
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr10_-_45847763 0.96 ENST00000616763.5
AGAP4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chr18_-_55403682 0.94 ENST00000564228.5
ENST00000630828.2
TCF4
transcription factor 4
chr9_-_26947222 0.90 ENST00000520884.5
ENST00000397292.8
PLAA
phospholipase A2 activating protein
chr6_-_112254485 0.90 ENST00000521398.5
ENST00000424408.6
ENST00000243219.7
LAMA4
laminin subunit alpha 4
chr9_+_137241277 0.86 ENST00000340384.5
TUBB4B
tubulin beta 4B class IVb
chr17_+_39667964 0.85 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr1_-_160579439 0.85 ENST00000368054.8
ENST00000368048.7
ENST00000311224.8
ENST00000368051.3
ENST00000534968.5
CD84
CD84 molecule
chr11_-_128842467 0.80 ENST00000392664.2
KCNJ1
potassium inwardly rectifying channel subfamily J member 1
chr19_+_35358821 0.75 ENST00000594310.1
FFAR3
free fatty acid receptor 3
chr7_+_20330893 0.74 ENST00000222573.5
ITGB8
integrin subunit beta 8
chr8_-_78805306 0.69 ENST00000639719.1
ENST00000263851.9
IL7
interleukin 7
chr10_-_73697881 0.61 ENST00000443782.6
AGAP5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr3_+_189789734 0.61 ENST00000437221.5
ENST00000392463.6
ENST00000392461.7
ENST00000449992.5
ENST00000456148.1
TP63
tumor protein p63
chr6_-_112254647 0.60 ENST00000455073.1
ENST00000522006.5
ENST00000519932.5
LAMA4
laminin subunit alpha 4
chrX_-_111412162 0.57 ENST00000637570.1
ENST00000356220.8
ENST00000636035.2
ENST00000637453.1
ENST00000635795.1
DCX
doublecortin
chr10_-_45847473 0.57 ENST00000448048.7
AGAP4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chrX_-_10677720 0.50 ENST00000453318.6
MID1
midline 1
chr3_+_148827800 0.49 ENST00000282957.9
ENST00000468341.1
CPB1
carboxypeptidase B1
chr19_+_51571249 0.47 ENST00000262259.7
ENST00000545217.5
ENST00000596504.1
ZNF175
zinc finger protein 175
chr10_-_77637558 0.47 ENST00000372421.10
ENST00000639370.1
ENST00000640773.1
ENST00000638895.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr8_+_23528995 0.46 ENST00000523930.1
SLC25A37
solute carrier family 25 member 37
chr4_-_122621011 0.45 ENST00000611104.2
ENST00000648588.1
IL21
interleukin 21
chr8_-_78805515 0.29 ENST00000379113.6
ENST00000541183.2
IL7
interleukin 7
chrX_+_96684712 0.28 ENST00000373049.8
DIAPH2
diaphanous related formin 2
chr17_+_41819201 0.28 ENST00000455106.1
FKBP10
FKBP prolyl isomerase 10
chr12_-_114406133 0.25 ENST00000405440.7
TBX5
T-box transcription factor 5
chr10_-_47523638 0.24 ENST00000452145.6
AGAP9
ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
chr7_-_151167692 0.22 ENST00000297537.5
GBX1
gastrulation brain homeobox 1
chr10_-_77637721 0.22 ENST00000638848.1
ENST00000639406.1
ENST00000618048.2
ENST00000639120.1
ENST00000640834.1
ENST00000639601.1
ENST00000638514.1
ENST00000457953.6
ENST00000639090.1
ENST00000639489.1
ENST00000372440.6
ENST00000404771.8
ENST00000638203.1
ENST00000638306.1
ENST00000638351.1
ENST00000638606.1
ENST00000639591.1
ENST00000640182.1
ENST00000640605.1
ENST00000640141.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr10_-_77637902 0.21 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr10_-_73698109 0.19 ENST00000374094.9
AGAP5
ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
chr12_+_56021005 0.17 ENST00000547167.6
IKZF4
IKAROS family zinc finger 4
chr6_-_112254555 0.11 ENST00000230538.12
ENST00000389463.9
ENST00000368638.5
ENST00000431543.6
ENST00000453937.2
LAMA4
laminin subunit alpha 4
chr3_+_189789643 0.11 ENST00000354600.10
TP63
tumor protein p63
chr10_-_77637633 0.10 ENST00000638223.1
ENST00000639544.1
ENST00000640807.1
ENST00000434208.6
ENST00000626620.3
ENST00000638575.1
ENST00000638759.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr18_+_58196736 0.08 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 54.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
3.0 35.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
2.6 7.7 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
2.3 9.0 GO:1990928 response to amino acid starvation(GO:1990928)
2.1 6.4 GO:0042137 sequestering of neurotransmitter(GO:0042137)
1.7 6.7 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
1.5 7.7 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
1.5 9.0 GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
1.5 7.5 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
1.4 4.2 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
1.3 8.0 GO:1904304 regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
1.3 3.9 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
1.2 7.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
1.2 3.5 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.0 4.8 GO:0035645 enteric smooth muscle cell differentiation(GO:0035645)
1.0 3.8 GO:0099558 maintenance of synapse structure(GO:0099558)
1.0 16.3 GO:0007021 tubulin complex assembly(GO:0007021)
1.0 2.9 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.9 2.8 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.9 15.9 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.9 9.3 GO:0035865 cellular response to potassium ion(GO:0035865)
0.8 14.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.8 2.5 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.8 3.3 GO:0021571 rhombomere 5 development(GO:0021571)
0.8 2.4 GO:0061590 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.8 2.3 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.5 3.3 GO:0061143 alveolar primary septum development(GO:0061143)
0.5 1.8 GO:0007538 primary sex determination(GO:0007538)
0.4 4.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.4 5.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.4 2.7 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.4 2.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.3 8.4 GO:0001502 cartilage condensation(GO:0001502)
0.3 0.8 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.3 3.0 GO:0034465 response to carbon monoxide(GO:0034465)
0.3 2.1 GO:0051414 response to cortisol(GO:0051414)
0.3 2.6 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.3 3.0 GO:0060539 diaphragm development(GO:0060539)
0.2 4.7 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2 3.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.2 0.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.2 2.0 GO:1902527 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) fat pad development(GO:0060613) positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) positive regulation of protein monoubiquitination(GO:1902527)
0.2 2.5 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.2 12.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.2 0.8 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.2 1.5 GO:1902949 positive regulation of tau-protein kinase activity(GO:1902949)
0.2 2.3 GO:0008212 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.2 2.0 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1 9.2 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 3.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 2.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.0 GO:0021603 cranial nerve formation(GO:0021603)
0.1 8.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.7 GO:0003334 keratinocyte development(GO:0003334)
0.1 3.8 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.1 0.2 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.1 1.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 3.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 4.5 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.1 4.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.9 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.7 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 3.0 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 1.0 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 2.9 GO:0030449 regulation of complement activation(GO:0030449)
0.0 1.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 1.3 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.4 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 2.9 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.0 0.9 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.0 16.3 GO:0097512 cardiac myofibril(GO:0097512)
0.8 6.4 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.7 25.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 8.0 GO:0031045 dense core granule(GO:0031045)
0.4 3.0 GO:1990635 proximal dendrite(GO:1990635)
0.3 4.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.3 3.8 GO:0043083 synaptic cleft(GO:0043083)
0.2 0.7 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.2 15.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 5.7 GO:0032982 myosin filament(GO:0032982)
0.1 1.3 GO:0097427 microtubule bundle(GO:0097427)
0.1 2.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 14.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 3.9 GO:0002102 podosome(GO:0002102)
0.1 46.8 GO:0005938 cell cortex(GO:0005938)
0.1 15.9 GO:0030426 growth cone(GO:0030426)
0.1 42.2 GO:0045121 membrane raft(GO:0045121)
0.1 1.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.6 GO:0005605 basal lamina(GO:0005605)
0.1 2.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 6.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 11.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 10.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 9.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 12.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 10.2 GO:0043025 neuronal cell body(GO:0043025)
0.0 3.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 5.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 9.5 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 25.4 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
3.4 10.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
3.1 9.3 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
2.0 35.9 GO:0008179 adenylate cyclase binding(GO:0008179)
1.5 4.5 GO:0035375 zymogen binding(GO:0035375)
1.3 6.4 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
1.0 3.0 GO:0030305 heparanase activity(GO:0030305)
0.8 9.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.7 4.8 GO:0004962 endothelin receptor activity(GO:0004962)
0.5 16.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.5 1.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.5 6.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.5 3.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.5 15.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 15.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 5.7 GO:0031432 titin binding(GO:0031432)
0.3 3.0 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.3 7.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.3 4.7 GO:0003680 AT DNA binding(GO:0003680)
0.3 7.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 2.8 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.2 9.0 GO:0000049 tRNA binding(GO:0000049)
0.2 3.4 GO:0035497 cAMP response element binding(GO:0035497)
0.2 0.7 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.2 2.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 2.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 3.8 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 2.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 3.0 GO:0070402 NADPH binding(GO:0070402)
0.1 1.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 4.3 GO:0008066 glutamate receptor activity(GO:0008066)
0.1 9.9 GO:0005179 hormone activity(GO:0005179)
0.1 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 2.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 8.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 3.3 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.9 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 10.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 4.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 3.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 9.8 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 1.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 8.9 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 0.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 6.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 25.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 2.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 7.4 PID RAS PATHWAY Regulation of Ras family activation
0.2 12.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 9.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 2.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 3.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 8.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 9.0 PID FGF PATHWAY FGF signaling pathway
0.1 15.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 6.8 PID ENDOTHELIN PATHWAY Endothelins
0.1 6.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 6.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 14.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.6 11.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.5 25.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.4 9.0 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.2 6.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 13.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 7.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 3.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 9.2 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 3.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 5.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 12.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 3.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 7.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.8 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway