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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXA4

Z-value: 1.37

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
HOXA4
ENSG00000197576.14 HOXA4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg38_v1_chr7_-_27130733_27130780-0.282.9e-05Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_74788542 10.40 ENST00000567571.5
CSK
C-terminal Src kinase
chr13_-_46142834 9.34 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr12_+_49750598 7.04 ENST00000552370.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr3_-_52452828 6.67 ENST00000496590.1
TNNC1
troponin C1, slow skeletal and cardiac type
chr13_-_41019289 6.61 ENST00000239882.7
ELF1
E74 like ETS transcription factor 1
chr2_-_43226594 5.90 ENST00000282388.4
ZFP36L2
ZFP36 ring finger protein like 2
chr10_+_11005301 5.88 ENST00000416382.6
ENST00000631460.1
ENST00000631816.1
CELF2
CUGBP Elav-like family member 2
chr19_-_42302766 5.42 ENST00000595530.5
ENST00000538771.5
ENST00000601865.5
PAFAH1B3
platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr12_+_56128217 5.09 ENST00000267113.4
ENST00000394048.10
ESYT1
extended synaptotagmin 1
chr15_+_80059635 4.75 ENST00000559157.5
ZFAND6
zinc finger AN1-type containing 6
chrX_-_123623155 4.74 ENST00000618150.4
THOC2
THO complex 2
chr6_+_32439866 4.63 ENST00000374982.5
ENST00000395388.7
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr17_-_10549652 4.58 ENST00000245503.10
MYH2
myosin heavy chain 2
chr17_-_10549612 4.53 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
MYH2
myosin heavy chain 2
chr15_+_80059568 4.42 ENST00000613266.4
ENST00000561060.5
ZFAND6
zinc finger AN1-type containing 6
chr6_+_63211446 4.26 ENST00000370659.1
FKBP1C
FKBP prolyl isomerase family member 1C
chr17_-_10549694 4.21 ENST00000622564.4
MYH2
myosin heavy chain 2
chr12_+_53454764 4.16 ENST00000439930.7
ENST00000548933.5
PCBP2
poly(rC) binding protein 2
chr7_+_95485898 4.04 ENST00000428113.5
ASB4
ankyrin repeat and SOCS box containing 4
chr10_-_119178791 3.95 ENST00000298510.4
PRDX3
peroxiredoxin 3
chr17_+_44957907 3.75 ENST00000678938.1
NMT1
N-myristoyltransferase 1
chr1_+_155689074 3.72 ENST00000343043.7
ENST00000421487.6
ENST00000535183.5
ENST00000368336.10
ENST00000465375.5
ENST00000470830.5
DAP3
death associated protein 3
chr22_+_22588155 3.69 ENST00000390302.3
IGLV2-33
immunoglobulin lambda variable 2-33 (non-functional)
chr12_+_53454819 3.50 ENST00000562264.5
PCBP2
poly(rC) binding protein 2
chr15_+_80059651 3.47 ENST00000561012.5
ENST00000261749.11
ENST00000564367.5
ENST00000558494.5
ZFAND6
zinc finger AN1-type containing 6
chr18_+_3247778 3.43 ENST00000217652.8
ENST00000578611.5
ENST00000583449.1
MYL12A
myosin light chain 12A
chr6_+_12716801 3.39 ENST00000674595.1
PHACTR1
phosphatase and actin regulator 1
chr12_-_56643499 3.27 ENST00000551570.5
ATP5F1B
ATP synthase F1 subunit beta
chr6_+_12716554 3.25 ENST00000676159.1
PHACTR1
phosphatase and actin regulator 1
chr3_+_107522936 3.23 ENST00000415149.6
ENST00000402543.5
ENST00000325805.13
ENST00000427402.5
BBX
BBX high mobility group box domain containing
chr7_-_141014629 3.19 ENST00000393008.7
MRPS33
mitochondrial ribosomal protein S33
chr6_+_12716760 3.07 ENST00000332995.12
PHACTR1
phosphatase and actin regulator 1
chr12_+_53454718 2.96 ENST00000552819.5
ENST00000455667.7
PCBP2
poly(rC) binding protein 2
chr11_-_62545629 2.88 ENST00000528508.5
ENST00000533365.5
AHNAK
AHNAK nucleoprotein
chr8_-_94436926 2.75 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr3_+_69084929 2.74 ENST00000273258.4
ARL6IP5
ADP ribosylation factor like GTPase 6 interacting protein 5
chr17_-_10518536 2.63 ENST00000226207.6
MYH1
myosin heavy chain 1
chr11_+_128693887 2.51 ENST00000281428.12
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr11_-_69819410 2.46 ENST00000334134.4
FGF3
fibroblast growth factor 3
chr11_-_13495984 2.41 ENST00000282091.6
PTH
parathyroid hormone
chr7_-_29195186 2.37 ENST00000449801.5
ENST00000409850.5
CPVL
carboxypeptidase vitellogenic like
chr17_-_50707855 2.33 ENST00000285243.7
ANKRD40
ankyrin repeat domain 40
chr1_-_41918858 2.27 ENST00000372583.6
HIVEP3
HIVEP zinc finger 3
chr14_-_36519679 2.25 ENST00000498187.6
NKX2-1
NK2 homeobox 1
chr1_+_167329044 2.21 ENST00000367862.9
POU2F1
POU class 2 homeobox 1
chr20_+_58889143 2.21 ENST00000470512.6
ENST00000464788.6
ENST00000469431.6
ENST00000478585.6
ENST00000604005.6
GNAS
GNAS complex locus
chr8_+_22567038 2.16 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr20_+_58889100 2.01 ENST00000477931.5
ENST00000485673.6
GNAS
GNAS complex locus
chr18_-_63158208 1.98 ENST00000678301.1
BCL2
BCL2 apoptosis regulator
chr1_-_193106048 1.96 ENST00000367440.3
GLRX2
glutaredoxin 2
chr11_+_128694052 1.91 ENST00000527786.7
ENST00000534087.3
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr20_+_58888779 1.89 ENST00000488546.6
ENST00000667293.2
ENST00000481039.6
ENST00000467321.6
GNAS
GNAS complex locus
chr3_+_69084973 1.87 ENST00000478935.1
ARL6IP5
ADP ribosylation factor like GTPase 6 interacting protein 5
chr3_-_120682215 1.84 ENST00000283871.10
HGD
homogentisate 1,2-dioxygenase
chr11_-_13496018 1.83 ENST00000529816.1
PTH
parathyroid hormone
chr7_+_100676112 1.74 ENST00000412215.5
ENST00000393924.1
GNB2
G protein subunit beta 2
chr10_+_113125536 1.70 ENST00000349937.7
TCF7L2
transcription factor 7 like 2
chr10_-_100065394 1.61 ENST00000441382.1
CPN1
carboxypeptidase N subunit 1
chr12_-_86256299 1.60 ENST00000552808.6
ENST00000547225.5
MGAT4C
MGAT4 family member C
chr19_+_33373694 1.44 ENST00000284000.9
CEBPG
CCAAT enhancer binding protein gamma
chr17_-_79950828 1.42 ENST00000572862.5
ENST00000573782.5
ENST00000574427.1
ENST00000570373.5
ENST00000340848.11
ENST00000576768.5
TBC1D16
TBC1 domain family member 16
chr5_-_59430600 1.41 ENST00000636120.1
PDE4D
phosphodiesterase 4D
chr1_+_160190567 1.39 ENST00000368078.8
CASQ1
calsequestrin 1
chr6_+_50818857 1.33 ENST00000393655.4
TFAP2B
transcription factor AP-2 beta
chr17_-_10469558 1.28 ENST00000255381.2
MYH4
myosin heavy chain 4
chr1_-_113871665 1.22 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chrX_+_37780049 1.22 ENST00000378588.5
CYBB
cytochrome b-245 beta chain
chr3_-_57199938 1.21 ENST00000473921.2
ENST00000295934.8
HESX1
HESX homeobox 1
chr10_-_104085847 1.20 ENST00000648076.2
COL17A1
collagen type XVII alpha 1 chain
chr12_-_86256267 1.18 ENST00000620241.4
MGAT4C
MGAT4 family member C
chr8_-_42501224 1.14 ENST00000520262.6
ENST00000517366.1
SLC20A2
solute carrier family 20 member 2
chr15_+_89088417 1.12 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
ABHD2
abhydrolase domain containing 2, acylglycerol lipase
chr6_-_55875583 1.11 ENST00000370830.4
BMP5
bone morphogenetic protein 5
chr1_+_213987929 1.09 ENST00000498508.6
ENST00000366958.9
PROX1
prospero homeobox 1
chr14_+_39265278 1.07 ENST00000554392.5
ENST00000555716.5
ENST00000341749.7
ENST00000557038.5
MIA2
MIA SH3 domain ER export factor 2
chr7_+_129375643 1.05 ENST00000490911.5
AHCYL2
adenosylhomocysteinase like 2
chr1_-_41918666 1.02 ENST00000372584.5
HIVEP3
HIVEP zinc finger 3
chr1_+_213988501 1.01 ENST00000261454.8
ENST00000435016.2
PROX1
prospero homeobox 1
chr4_-_65670339 0.98 ENST00000273854.7
EPHA5
EPH receptor A5
chr5_+_159916475 0.97 ENST00000306675.5
ADRA1B
adrenoceptor alpha 1B
chr20_+_33562365 0.96 ENST00000346541.7
ENST00000397800.5
ENST00000492345.5
CBFA2T2
CBFA2/RUNX1 partner transcriptional co-repressor 2
chr17_-_41382298 0.94 ENST00000394001.3
KRT34
keratin 34
chr2_+_127645864 0.93 ENST00000544369.5
GPR17
G protein-coupled receptor 17
chr2_+_54456311 0.91 ENST00000615901.4
ENST00000356805.9
SPTBN1
spectrin beta, non-erythrocytic 1
chr12_-_91004965 0.91 ENST00000261172.8
EPYC
epiphycan
chr6_-_26234978 0.90 ENST00000244534.7
H1-3
H1.3 linker histone, cluster member
chr12_-_23951020 0.89 ENST00000441133.2
ENST00000545921.5
SOX5
SRY-box transcription factor 5
chr18_-_55351977 0.87 ENST00000643689.1
TCF4
transcription factor 4
chr4_-_65670478 0.78 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPHA5
EPH receptor A5
chr7_-_13986498 0.75 ENST00000420159.6
ENST00000399357.7
ENST00000403527.5
ETV1
ETS variant transcription factor 1
chrX_-_120311408 0.75 ENST00000309720.9
TMEM255A
transmembrane protein 255A
chr17_-_48593748 0.73 ENST00000239151.6
HOXB5
homeobox B5
chr12_-_119803383 0.69 ENST00000392520.2
ENST00000678677.1
ENST00000679249.1
ENST00000676849.1
CIT
citron rho-interacting serine/threonine kinase
chr5_-_1882902 0.69 ENST00000231357.7
IRX4
iroquois homeobox 4
chr7_+_107470050 0.68 ENST00000304402.6
GPR22
G protein-coupled receptor 22
chr17_-_10421944 0.67 ENST00000403437.2
MYH8
myosin heavy chain 8
chr6_+_50818701 0.61 ENST00000344788.7
TFAP2B
transcription factor AP-2 beta
chr3_+_122384167 0.57 ENST00000232125.9
ENST00000477892.5
ENST00000469967.1
FAM162A
family with sequence similarity 162 member A
chr10_-_33334382 0.56 ENST00000374823.9
ENST00000374821.9
ENST00000374816.7
NRP1
neuropilin 1
chr3_-_179266971 0.53 ENST00000349697.2
ENST00000497599.5
KCNMB3
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr17_+_39738317 0.53 ENST00000394211.7
GRB7
growth factor receptor bound protein 7
chr6_+_151690492 0.51 ENST00000404742.5
ENST00000440973.5
ESR1
estrogen receptor 1
chr6_+_99606833 0.44 ENST00000369215.5
PRDM13
PR/SET domain 13
chrX_-_120311533 0.44 ENST00000440464.5
ENST00000519908.1
TMEM255A
transmembrane protein 255A
chr19_-_1021114 0.38 ENST00000333175.9
ENST00000356663.8
TMEM259
transmembrane protein 259
chr6_+_31546845 0.37 ENST00000376146.8
NFKBIL1
NFKB inhibitor like 1
chr17_+_42844573 0.36 ENST00000253799.8
ENST00000452774.2
AOC2
amine oxidase copper containing 2
chr10_-_90921079 0.35 ENST00000371697.4
ANKRD1
ankyrin repeat domain 1
chr2_-_55334529 0.35 ENST00000645860.1
ENST00000642563.1
ENST00000647396.1
CCDC88A
coiled-coil domain containing 88A
chr2_+_127646145 0.35 ENST00000486700.2
ENST00000272644.7
GPR17
G protein-coupled receptor 17
chr3_-_62374293 0.33 ENST00000486811.5
FEZF2
FEZ family zinc finger 2
chr14_+_36661852 0.33 ENST00000361487.7
PAX9
paired box 9
chr12_+_53425070 0.32 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor type 2
chr5_+_53480619 0.32 ENST00000396947.7
ENST00000256759.8
FST
follistatin
chr7_-_13986439 0.31 ENST00000443608.5
ENST00000438956.5
ETV1
ETS variant transcription factor 1
chr20_+_58889168 0.29 ENST00000480975.5
ENST00000480232.6
ENST00000484504.5
GNAS
GNAS complex locus
chr1_+_81306096 0.28 ENST00000370721.5
ENST00000370727.5
ENST00000370725.5
ENST00000370723.5
ENST00000370728.5
ENST00000370730.5
ADGRL2
adhesion G protein-coupled receptor L2
chr11_+_121101243 0.23 ENST00000392793.6
ENST00000642222.1
TECTA
tectorin alpha
chr14_-_37595224 0.19 ENST00000250448.5
FOXA1
forkhead box A1
chr10_-_73655984 0.19 ENST00000394810.3
SYNPO2L
synaptopodin 2 like
chr5_-_146182475 0.18 ENST00000674158.1
ENST00000674191.1
ENST00000274562.13
LARS1
leucyl-tRNA synthetase 1
chrX_-_120311452 0.18 ENST00000371369.9
TMEM255A
transmembrane protein 255A
chr2_-_68871382 0.17 ENST00000295379.2
BMP10
bone morphogenetic protein 10
chrX_-_85379659 0.17 ENST00000262753.9
POF1B
POF1B actin binding protein
chr9_-_110579880 0.15 ENST00000401783.6
ENST00000374461.1
SVEP1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chrX_+_130339941 0.11 ENST00000218197.9
SLC25A14
solute carrier family 25 member 14
chr12_+_29223730 0.11 ENST00000547116.5
FAR2
fatty acyl-CoA reductase 2
chr12_-_10807286 0.10 ENST00000240615.3
TAS2R8
taste 2 receptor member 8
chr2_-_190062721 0.09 ENST00000260950.5
MSTN
myostatin
chr12_+_29223659 0.08 ENST00000182377.8
FAR2
fatty acyl-CoA reductase 2
chr7_-_13989658 0.07 ENST00000430479.6
ENST00000433547.1
ENST00000405192.6
ETV1
ETS variant transcription factor 1
chr6_-_116126120 0.06 ENST00000452729.1
ENST00000651968.1
ENST00000243222.8
COL10A1
collagen type X alpha 1 chain
chr5_-_146182591 0.04 ENST00000510191.5
ENST00000674277.1
ENST00000674447.1
ENST00000674270.1
ENST00000394434.7
ENST00000674290.1
ENST00000674398.1
ENST00000674174.1
LARS1
leucyl-tRNA synthetase 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0002086 diaphragm contraction(GO:0002086)
1.7 10.4 GO:0042997 negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
1.5 4.6 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.3 4.0 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
1.2 7.0 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.1 4.2 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.9 3.8 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
0.9 13.3 GO:0001778 plasma membrane repair(GO:0001778)
0.8 4.6 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.7 5.9 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.7 2.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.6 1.9 GO:0097272 ammonia homeostasis(GO:0097272)
0.6 10.6 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.6 2.2 GO:0021759 globus pallidus development(GO:0021759)
0.5 2.0 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.4 12.6 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.4 8.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.4 1.2 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.4 6.4 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.4 4.7 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.4 1.1 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.3 1.6 GO:0030070 insulin processing(GO:0030070)
0.3 7.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 1.0 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.2 4.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 1.8 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 0.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.2 4.4 GO:0035855 megakaryocyte development(GO:0035855)
0.2 2.0 GO:0042262 DNA protection(GO:0042262)
0.2 1.4 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.2 1.4 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 1.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.9 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 1.7 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.6 GO:1905040 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1 5.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.4 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.5 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 1.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 6.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.2 GO:0030916 otic vesicle formation(GO:0030916)
0.1 1.8 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 3.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.3 GO:0043697 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 9.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 0.3 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.1 0.2 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.4 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.2 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) prostate gland stromal morphogenesis(GO:0060741) epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 5.1 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 1.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 3.4 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.9 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.9 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.0 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 1.7 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 1.4 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 1.9 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 2.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.4 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 2.2 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.0 3.7 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 2.5 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.3 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 0.5 GO:0034063 stress granule assembly(GO:0034063)
0.0 3.1 GO:0060348 bone development(GO:0060348)
0.0 0.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.4 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.0 0.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 13.3 GO:0005826 actomyosin contractile ring(GO:0005826)
1.1 6.7 GO:1990584 cardiac Troponin complex(GO:1990584)
0.5 4.7 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.5 4.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.4 9.3 GO:0001891 phagocytic cup(GO:0001891)
0.3 4.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 6.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 4.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 5.1 GO:0044232 organelle membrane contact site(GO:0044232)
0.2 1.4 GO:0014802 terminal cisterna(GO:0014802)
0.2 4.6 GO:0032982 myosin filament(GO:0032982)
0.2 0.9 GO:0032437 cuticular plate(GO:0032437)
0.1 1.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 6.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.0 GO:0046930 pore complex(GO:0046930)
0.1 1.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 10.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 1.2 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 3.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.7 GO:0043034 costamere(GO:0043034)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 15.4 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 2.5 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 1.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 2.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 10.6 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
1.1 5.4 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
1.0 7.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.9 3.8 GO:0019107 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.7 6.7 GO:0031013 troponin I binding(GO:0031013)
0.5 4.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.4 2.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 15.3 GO:0000146 microfilament motor activity(GO:0000146)
0.4 10.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.3 4.6 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 1.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.3 5.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 2.0 GO:0030614 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
0.3 9.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 7.8 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.2 1.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.2 2.1 GO:0050692 DBD domain binding(GO:0050692)
0.2 12.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 4.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 1.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 2.0 GO:0051434 BH3 domain binding(GO:0051434)
0.2 4.2 GO:0048018 receptor agonist activity(GO:0048018)
0.1 1.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 3.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 2.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 2.9 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 5.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.3 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.4 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.1 0.5 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 2.2 GO:0017166 vinculin binding(GO:0017166)
0.1 1.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 2.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.6 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.3 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.1 3.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 1.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.8 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 1.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 3.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 6.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.3 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 11.5 GO:0051020 GTPase binding(GO:0051020)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 1.7 GO:0003774 motor activity(GO:0003774)
0.0 0.3 GO:0048185 activin binding(GO:0048185)
0.0 0.4 GO:0051959 protein kinase B binding(GO:0043422) dynein light intermediate chain binding(GO:0051959)
0.0 3.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 5.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 15.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 7.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 5.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.7 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 1.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 4.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.5 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 4.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 8.1 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.2 10.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 7.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 5.7 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.5 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 2.2 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 1.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 2.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 3.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 4.2 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects