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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXA5

Z-value: 1.44

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Transcription factors associated with HOXA5

Gene Symbol Gene ID Gene Info
HOXA5
ENSG00000106004.5 HOXA5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA5hg38_v1_chr7_-_27143672_27143719-0.291.1e-05Click!

Activity profile of HOXA5 motif

Sorted Z-values of HOXA5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_+_30427950 15.46 ENST00000436446.1
UBE2L5
ubiquitin conjugating enzyme E2 L5
chr20_+_4686320 9.96 ENST00000430350.2
PRNP
prion protein
chr20_+_4686448 7.93 ENST00000379440.9
ENST00000424424.2
ENST00000457586.2
PRNP
prion protein
chr8_-_27838034 7.33 ENST00000522944.5
PBK
PDZ binding kinase
chr1_-_45542726 5.96 ENST00000676549.1
PRDX1
peroxiredoxin 1
chr11_-_33722710 5.37 ENST00000415002.7
ENST00000437761.6
ENST00000445143.6
CD59
CD59 molecule (CD59 blood group)
chr14_+_77708076 5.14 ENST00000238688.9
ENST00000557342.6
ENST00000557623.5
ENST00000557431.5
ENST00000556831.5
ENST00000556375.5
ENST00000553981.1
SLIRP
SRA stem-loop interacting RNA binding protein
chr1_+_84144260 4.26 ENST00000370685.7
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr3_+_35679614 3.81 ENST00000474696.5
ENST00000412048.5
ENST00000396482.6
ENST00000432682.5
ARPP21
cAMP regulated phosphoprotein 21
chr11_-_11353241 3.75 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr3_+_130850585 3.61 ENST00000505330.5
ENST00000504381.5
ENST00000507488.6
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr5_+_72848115 3.43 ENST00000679378.1
TNPO1
transportin 1
chr18_-_36129305 3.41 ENST00000269187.10
ENST00000590986.5
ENST00000440549.6
SLC39A6
solute carrier family 39 member 6
chr12_-_54259531 3.36 ENST00000550411.5
ENST00000439541.6
CBX5
chromobox 5
chr11_-_33722941 3.33 ENST00000652678.1
CD59
CD59 molecule (CD59 blood group)
chr6_-_116254063 3.16 ENST00000420283.3
TSPYL4
TSPY like 4
chr6_-_17706852 3.00 ENST00000262077.3
NUP153
nucleoporin 153
chr19_+_41262480 2.96 ENST00000352456.7
ENST00000595018.5
ENST00000597725.5
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U like 1
chr16_-_66730216 2.87 ENST00000569320.5
DYNC1LI2
dynein cytoplasmic 1 light intermediate chain 2
chr3_+_36993798 2.86 ENST00000455445.6
ENST00000539477.6
ENST00000435176.5
ENST00000429117.5
ENST00000441265.6
MLH1
mutL homolog 1
chr16_+_14833713 2.73 ENST00000287667.12
ENST00000620755.4
ENST00000610363.4
NOMO1
NODAL modulator 1
chr4_-_102825526 2.73 ENST00000504211.5
ENST00000508476.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr8_-_140764386 2.73 ENST00000520151.5
ENST00000519024.5
ENST00000519465.5
PTK2
protein tyrosine kinase 2
chr4_-_102825854 2.66 ENST00000350435.11
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr3_-_79019444 2.64 ENST00000618833.4
ENST00000436010.6
ENST00000618846.4
ROBO1
roundabout guidance receptor 1
chrX_+_40581035 2.62 ENST00000447485.6
ATP6AP2
ATPase H+ transporting accessory protein 2
chr14_+_65411845 2.58 ENST00000556518.5
ENST00000557164.5
FUT8
fucosyltransferase 8
chr11_+_9384621 2.58 ENST00000379719.8
ENST00000527431.1
ENST00000630083.1
IPO7
importin 7
chr8_-_47960126 2.55 ENST00000314191.7
ENST00000338368.7
PRKDC
protein kinase, DNA-activated, catalytic subunit
chrX_-_77634229 2.51 ENST00000675732.1
ATRX
ATRX chromatin remodeler
chr1_-_170074568 2.51 ENST00000367767.5
ENST00000361580.7
ENST00000538366.5
KIFAP3
kinesin associated protein 3
chr7_-_23470469 2.43 ENST00000258729.8
IGF2BP3
insulin like growth factor 2 mRNA binding protein 3
chr11_+_9664061 2.42 ENST00000447399.6
ENST00000318950.11
SWAP70
switching B cell complex subunit SWAP70
chr6_-_154356735 2.37 ENST00000367220.8
ENST00000265198.8
ENST00000520261.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr5_-_135399863 2.33 ENST00000510038.1
ENST00000304332.8
MACROH2A1
macroH2A.1 histone
chr6_+_122779707 2.29 ENST00000368444.8
ENST00000356535.4
FABP7
fatty acid binding protein 7
chr11_-_6683282 2.27 ENST00000532203.1
ENST00000288937.7
MRPL17
mitochondrial ribosomal protein L17
chr1_+_204870831 2.22 ENST00000404076.5
ENST00000539706.6
NFASC
neurofascin
chr3_+_172039556 2.20 ENST00000415807.7
ENST00000421757.5
FNDC3B
fibronectin type III domain containing 3B
chr3_+_196744 2.17 ENST00000256509.7
ENST00000397491.6
CHL1
cell adhesion molecule L1 like
chr4_-_102825767 2.13 ENST00000505207.5
ENST00000502404.5
ENST00000507845.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr1_-_247458105 2.12 ENST00000641149.1
ENST00000641527.1
OR2B11
olfactory receptor family 2 subfamily B member 11
chr7_+_32979445 1.89 ENST00000418354.5
ENST00000490776.3
FKBP9
FKBP prolyl isomerase 9
chr16_-_21278282 1.80 ENST00000572914.2
CRYM
crystallin mu
chr10_-_20897288 1.80 ENST00000377122.9
NEBL
nebulette
chr11_-_115504389 1.76 ENST00000545380.5
ENST00000452722.7
ENST00000331581.11
ENST00000537058.5
ENST00000536727.5
ENST00000542447.6
CADM1
cell adhesion molecule 1
chr22_-_41286168 1.69 ENST00000356244.8
RANGAP1
Ran GTPase activating protein 1
chr7_-_100119840 1.65 ENST00000437822.6
TAF6
TATA-box binding protein associated factor 6
chr10_-_125816510 1.64 ENST00000650587.1
UROS
uroporphyrinogen III synthase
chr1_+_154257071 1.63 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2 like
chr2_-_157444044 1.61 ENST00000264192.8
CYTIP
cytohesin 1 interacting protein
chr4_+_73740541 1.57 ENST00000401931.1
ENST00000307407.8
CXCL8
C-X-C motif chemokine ligand 8
chr7_+_2354810 1.54 ENST00000360876.9
ENST00000413917.5
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3 subunit B
chr18_-_63644250 1.43 ENST00000341074.10
ENST00000436264.1
SERPINB4
serpin family B member 4
chr7_-_100119323 1.28 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chr10_+_74176741 1.26 ENST00000673027.1
ENST00000372734.5
ENST00000541550.6
ADK
adenosine kinase
chrX_+_100644183 1.15 ENST00000640889.1
ENST00000373004.5
SRPX2
sushi repeat containing protein X-linked 2
chr9_-_14321948 1.11 ENST00000635877.1
ENST00000636432.1
ENST00000646622.1
NFIB
nuclear factor I B
chr12_+_25052732 1.02 ENST00000547044.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chrX_+_54807599 0.96 ENST00000375053.6
ENST00000627068.2
ENST00000375068.6
ENST00000347546.8
MAGED2
MAGE family member D2
chr15_+_77420880 0.91 ENST00000336216.9
ENST00000558176.1
HMG20A
high mobility group 20A
chr10_+_17228215 0.88 ENST00000544301.7
VIM
vimentin
chr4_-_163613505 0.85 ENST00000339875.9
MARCHF1
membrane associated ring-CH-type finger 1
chr3_+_173398438 0.84 ENST00000457714.5
NLGN1
neuroligin 1
chr7_-_22193824 0.83 ENST00000401957.6
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr18_-_55588184 0.82 ENST00000354452.8
ENST00000565908.6
ENST00000635822.2
TCF4
transcription factor 4
chr13_-_46897021 0.80 ENST00000542664.4
ENST00000543956.5
HTR2A
5-hydroxytryptamine receptor 2A
chr19_+_15949008 0.79 ENST00000322107.1
OR10H4
olfactory receptor family 10 subfamily H member 4
chr2_+_113406368 0.75 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr17_-_76737321 0.58 ENST00000359995.10
ENST00000508921.7
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
SRSF2
serine and arginine rich splicing factor 2
chr10_-_102120246 0.57 ENST00000425280.2
LDB1
LIM domain binding 1
chr11_-_72112068 0.53 ENST00000537644.5
ENST00000538919.5
ENST00000539395.1
ENST00000542531.5
ANAPC15
anaphase promoting complex subunit 15
chr13_+_97222296 0.52 ENST00000343600.8
ENST00000376673.7
ENST00000679496.1
ENST00000345429.10
MBNL2
muscleblind like splicing regulator 2
chr6_+_26365215 0.51 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
BTN3A2
butyrophilin subfamily 3 member A2
chr2_+_165239432 0.49 ENST00000636071.2
ENST00000636985.2
SCN2A
sodium voltage-gated channel alpha subunit 2
chr5_+_70025247 0.46 ENST00000380751.9
ENST00000380750.8
ENST00000503931.5
ENST00000506542.1
SERF1B
small EDRK-rich factor 1B
chr17_-_51046868 0.44 ENST00000510283.5
ENST00000510855.1
SPAG9
sperm associated antigen 9
chr6_+_26365176 0.39 ENST00000377708.7
BTN3A2
butyrophilin subfamily 3 member A2
chr12_+_25052634 0.38 ENST00000548766.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr7_-_22194709 0.36 ENST00000458533.5
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr10_+_18260715 0.36 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr18_+_34710307 0.33 ENST00000679796.1
DTNA
dystrobrevin alpha
chr1_+_177170916 0.32 ENST00000361539.5
BRINP2
BMP/retinoic acid inducible neural specific 2
chr7_+_142384328 0.30 ENST00000390361.3
TRBV7-3
T cell receptor beta variable 7-3
chr12_+_110614097 0.27 ENST00000471804.7
ENST00000377654.5
ENST00000614115.5
ENST00000397655.7
ENST00000549123.6
ENST00000679401.1
ENST00000397659.9
ENST00000680445.1
TCTN1
tectonic family member 1
chr18_+_44697118 0.22 ENST00000677077.1
SETBP1
SET binding protein 1
chr12_-_14961559 0.21 ENST00000228945.9
ENST00000541546.5
ARHGDIB
Rho GDP dissociation inhibitor beta
chr2_+_165294031 0.21 ENST00000283256.10
SCN2A
sodium voltage-gated channel alpha subunit 2
chr3_+_12351470 0.19 ENST00000287820.10
PPARG
peroxisome proliferator activated receptor gamma
chr18_+_3252267 0.16 ENST00000536605.1
ENST00000580887.5
MYL12A
myosin light chain 12A
chr1_+_115029823 0.14 ENST00000256592.3
TSHB
thyroid stimulating hormone subunit beta
chr14_+_23556253 0.12 ENST00000556015.5
ENST00000554970.1
ENST00000288014.7
ENST00000554789.1
THTPA
thiamine triphosphatase
chr2_+_165239388 0.08 ENST00000424833.5
ENST00000375437.7
ENST00000631182.3
SCN2A
sodium voltage-gated channel alpha subunit 2
chr2_-_206218024 0.06 ENST00000407325.6
ENST00000612892.4
ENST00000411719.1
GPR1
G protein-coupled receptor 1
chr4_+_70430487 0.05 ENST00000413702.5
MUC7
mucin 7, secreted
chr5_-_177783398 0.03 ENST00000510276.5
FAM153A
family with sequence similarity 153 member A
chr16_+_10877181 0.01 ENST00000618207.4
ENST00000618327.4
ENST00000324288.14
ENST00000381835.9
CIITA
class II major histocompatibility complex transactivator
chr22_-_28306645 0.01 ENST00000612946.4
TTC28
tetratricopeptide repeat domain 28
chr5_+_140848360 0.01 ENST00000532602.2
PCDHA9
protocadherin alpha 9
chr1_+_197268204 0.00 ENST00000535699.5
ENST00000538660.5
CRB1
crumbs cell polarity complex component 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 17.9 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535)
1.7 8.7 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
1.3 5.1 GO:0000961 negative regulation of mitochondrial RNA catabolic process(GO:0000961)
1.0 3.0 GO:0075732 viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594)
0.9 2.6 GO:0036071 N-glycan fucosylation(GO:0036071)
0.8 2.5 GO:0099403 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.8 2.5 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.8 2.4 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.7 2.9 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.7 4.3 GO:0097338 response to clozapine(GO:0097338)
0.7 2.6 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.6 3.6 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.5 1.4 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.4 2.5 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.4 1.7 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.4 1.6 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.4 3.4 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.3 1.3 GO:0006169 adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216)
0.3 1.8 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 2.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 2.6 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 3.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 0.8 GO:0099543 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.2 2.7 GO:0038007 netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964)
0.2 0.6 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.2 1.6 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 6.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 1.5 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.2 0.8 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 7.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 1.6 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.1 2.4 GO:0015671 oxygen transport(GO:0015671)
0.1 1.8 GO:0006554 lysine catabolic process(GO:0006554) thyroid hormone transport(GO:0070327)
0.1 1.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 1.1 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 1.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 7.9 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.1 2.3 GO:0060134 prepulse inhibition(GO:0060134)
0.1 0.9 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 1.8 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 0.2 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.8 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 2.3 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.1 0.4 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 2.9 GO:0051642 centrosome localization(GO:0051642)
0.1 2.2 GO:0035640 exploration behavior(GO:0035640)
0.1 0.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 1.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.9 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 2.6 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 3.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 3.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 3.0 GO:0051028 mRNA transport(GO:0051028)
0.0 3.0 GO:0030307 positive regulation of cell growth(GO:0030307)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 26.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.8 2.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.8 2.5 GO:0016939 kinesin II complex(GO:0016939)
0.7 2.9 GO:0005715 late recombination nodule(GO:0005715)
0.6 1.7 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.5 2.5 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.4 2.2 GO:0097454 Schwann cell microvillus(GO:0097454)
0.3 3.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.2 4.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 3.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 1.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 2.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 2.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.6 GO:0035061 interchromatin granule(GO:0035061)
0.1 1.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.8 GO:0070852 cell body fiber(GO:0070852)
0.1 3.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 4.3 GO:0036126 sperm flagellum(GO:0036126)
0.1 1.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.8 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 6.0 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 2.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.6 GO:0005643 nuclear pore(GO:0005643)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.0 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 6.5 GO:0010008 endosome membrane(GO:0010008)
0.0 3.6 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 17.9 GO:1903135 cupric ion binding(GO:1903135)
0.9 2.6 GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.8 2.5 GO:0015616 DNA translocase activity(GO:0015616)
0.7 6.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.5 2.5 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.5 1.8 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.4 1.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.3 2.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 1.3 GO:0004001 adenosine kinase activity(GO:0004001)
0.3 4.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 8.7 GO:0001848 complement binding(GO:0001848)
0.2 2.9 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.2 2.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 2.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 0.9 GO:1990254 keratin filament binding(GO:1990254)
0.2 3.2 GO:0008432 JUN kinase binding(GO:0008432)
0.2 3.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 7.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 2.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 3.0 GO:0043495 protein anchor(GO:0043495)
0.1 7.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 3.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.6 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 1.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.1 2.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 3.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 2.5 GO:0019894 kinesin binding(GO:0019894)
0.0 0.8 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 9.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 2.5 GO:0005516 calmodulin binding(GO:0005516)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.2 2.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 10.1 PID BARD1 PATHWAY BARD1 signaling events
0.1 3.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 7.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 6.0 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 2.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 4.2 PID AURORA B PATHWAY Aurora B signaling
0.0 1.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 18.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.2 7.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 3.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 3.4 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 2.5 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 4.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 2.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 2.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.5 REACTOME KINESINS Genes involved in Kinesins
0.1 2.6 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 3.0 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 2.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 3.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.8 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 1.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.7 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 2.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 3.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones