Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for HOXB13

Z-value: 0.72

Motif logo

logo of

Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.8 HOXB13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg38_v1_chr17_-_48728705_48728756-0.019.1e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_189179754 7.05 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr9_+_73151833 5.08 ENST00000456643.5
ENST00000257497.11
ENST00000415424.5
ANXA1
annexin A1
chr1_+_84164962 4.47 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr18_-_55321986 4.23 ENST00000570287.6
TCF4
transcription factor 4
chr9_+_122370523 4.10 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr18_-_55322215 3.79 ENST00000457482.7
TCF4
transcription factor 4
chr15_-_55249029 3.43 ENST00000566877.5
RAB27A
RAB27A, member RAS oncogene family
chr1_+_84164370 3.21 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr9_+_122371036 3.14 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr6_+_6588708 3.07 ENST00000230568.5
LY86
lymphocyte antigen 86
chr1_+_65992389 2.32 ENST00000423207.6
PDE4B
phosphodiesterase 4B
chr18_+_3252267 2.32 ENST00000536605.1
ENST00000580887.5
MYL12A
myosin light chain 12A
chr2_-_24328113 2.15 ENST00000622089.4
ITSN2
intersectin 2
chr11_+_118530990 2.05 ENST00000411589.6
ENST00000359862.8
ENST00000442938.6
TMEM25
transmembrane protein 25
chr9_+_122371014 1.95 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_-_14180779 1.68 ENST00000380924.1
ENST00000543693.5
NFIB
nuclear factor I B
chr9_-_128067310 1.57 ENST00000373078.5
NAIF1
nuclear apoptosis inducing factor 1
chr16_-_24931090 1.52 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr16_-_24930952 1.48 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17
chr5_+_136160986 1.36 ENST00000507637.1
SMAD5
SMAD family member 5
chr3_-_115071333 1.18 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr1_-_155910881 1.02 ENST00000609492.1
ENST00000368322.7
RIT1
Ras like without CAAX 1
chr14_-_50116553 0.99 ENST00000395860.7
ENST00000395859.2
VCPKMT
valosin containing protein lysine methyltransferase
chr19_+_35143237 0.98 ENST00000586063.5
ENST00000270310.7
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chr19_+_47994625 0.76 ENST00000339841.7
ELSPBP1
epididymal sperm binding protein 1
chr19_+_47994696 0.74 ENST00000596043.5
ENST00000597519.5
ELSPBP1
epididymal sperm binding protein 1
chr1_-_149812359 0.72 ENST00000369167.2
ENST00000545683.1
H2BC18
H2B clustered histone 18
chr2_-_216013517 0.59 ENST00000263268.11
MREG
melanoregulin
chr8_+_96584920 0.59 ENST00000521590.5
SDC2
syndecan 2
chr7_+_16661182 0.55 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
BZW2
basic leucine zipper and W2 domains 2
chr6_-_43053832 0.36 ENST00000265348.9
ENST00000674134.1
ENST00000674100.1
CUL7
cullin 7
chr5_-_140673568 0.35 ENST00000542735.2
DND1
DND microRNA-mediated repression inhibitor 1
chr4_+_67558719 0.32 ENST00000265404.7
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr4_-_163613505 0.32 ENST00000339875.9
MARCHF1
membrane associated ring-CH-type finger 1
chr20_+_58907981 0.32 ENST00000656419.1
GNAS
GNAS complex locus
chr5_+_102808057 0.24 ENST00000684043.1
ENST00000682407.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr1_+_210328244 0.21 ENST00000541565.5
ENST00000413764.6
HHAT
hedgehog acyltransferase
chr18_+_3252208 0.18 ENST00000578562.6
MYL12A
myosin light chain 12A
chr1_+_78303865 0.16 ENST00000370758.5
PTGFR
prostaglandin F receptor
chr21_-_34526850 0.15 ENST00000481448.5
ENST00000381132.6
RCAN1
regulator of calcineurin 1
chr1_+_44405164 0.12 ENST00000355387.6
RNF220
ring finger protein 220
chr1_-_45491150 0.10 ENST00000372086.4
TESK2
testis associated actin remodelling kinase 2
chr11_+_63838902 0.04 ENST00000377810.8
MARK2
microtubule affinity regulating kinase 2
chr17_-_48728705 0.03 ENST00000290295.8
HOXB13
homeobox B13
chr1_+_50105666 0.02 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr17_-_41382298 0.00 ENST00000394001.3
KRT34
keratin 34

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0036292 DNA rewinding(GO:0036292)
1.4 7.0 GO:2000542 negative regulation of gastrulation(GO:2000542)
1.3 7.7 GO:0097338 response to clozapine(GO:0097338)
0.6 3.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.4 9.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 3.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 1.4 GO:0001880 Mullerian duct regression(GO:0001880)
0.2 2.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.7 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.3 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.1 0.6 GO:0008218 bioluminescence(GO:0008218)
0.1 1.5 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.2 GO:0018032 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.1 2.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 1.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 8.0 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 2.8 GO:0070527 platelet aggregation(GO:0070527)
0.0 1.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.4 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.2 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.6 GO:0032402 melanosome transport(GO:0032402)
0.0 1.6 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 1.0 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.2 GO:0018345 protein palmitoylation(GO:0018345)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0005588 collagen type V trimer(GO:0005588)
0.8 5.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.4 7.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 3.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.4 GO:1990393 3M complex(GO:1990393)
0.1 9.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 8.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.2 GO:0016459 myosin complex(GO:0016459)
0.0 3.0 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.0 5.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.5 7.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 8.0 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 3.4 GO:0031489 myosin V binding(GO:0031489)
0.1 1.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 7.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 2.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.2 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 2.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 3.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 1.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.4 GO:0035198 miRNA binding(GO:0035198)
0.0 1.0 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 NABA COLLAGENS Genes encoding collagen proteins
0.1 7.7 PID IL3 PATHWAY IL3-mediated signaling events
0.1 5.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 1.4 PID ALK2 PATHWAY ALK2 signaling events
0.1 8.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 5.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 3.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 8.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 7.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 9.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.7 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.0 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 4.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.6 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 3.1 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 3.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP