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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXB3

Z-value: 1.80

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Transcription factors associated with HOXB3

Gene Symbol Gene ID Gene Info
ENSG00000120093.12 HOXB3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB3hg38_v1_chr17_-_48590231_485902580.432.4e-11Click!

Activity profile of HOXB3 motif

Sorted Z-values of HOXB3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_+_25160631 17.11 ENST00000510415.1
ENST00000507794.2
ENST00000512921.4
SEPSECS antisense RNA 1 (head to head)
phosphatidylinositol 4-kinase type 2 beta
chr8_-_30812867 9.79 ENST00000518243.5
protein phosphatase 2 catalytic subunit beta
chr5_+_36608146 9.05 ENST00000381918.4
ENST00000513646.1
solute carrier family 1 member 3
chrX_-_13817027 8.67 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr4_+_112860981 7.18 ENST00000671704.1
ankyrin 2
chr1_-_230745574 6.97 ENST00000681269.1
angiotensinogen
chr4_+_112860912 6.95 ENST00000671951.1
ankyrin 2
chr8_+_22275309 6.86 ENST00000356766.11
ENST00000521356.5
piwi like RNA-mediated gene silencing 2
chr19_+_17527250 6.75 ENST00000599164.6
ENST00000449408.6
ENST00000600871.5
ENST00000599124.1
niban apoptosis regulator 3
chr4_+_112861053 6.73 ENST00000672221.1
ankyrin 2
chr5_+_36606355 6.66 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
solute carrier family 1 member 3
chr3_+_319683 6.42 ENST00000620033.4
cell adhesion molecule L1 like
chr4_-_175812746 6.13 ENST00000393658.6
glycoprotein M6A
chr6_-_52840843 5.96 ENST00000370989.6
glutathione S-transferase alpha 5
chr11_+_121576760 5.92 ENST00000532694.5
ENST00000534286.5
sortilin related receptor 1
chr6_-_62286161 5.67 ENST00000281156.5
KH RNA binding domain containing, signal transduction associated 2
chr17_+_1771688 5.44 ENST00000572048.1
ENST00000573763.1
serpin family F member 1
chr11_-_117877463 5.40 ENST00000527717.5
FXYD domain containing ion transport regulator 6
chr11_+_95789965 5.36 ENST00000537677.5
centrosomal protein 57
chr5_+_140848360 5.34 ENST00000532602.2
protocadherin alpha 9
chr19_+_9185594 5.32 ENST00000344248.4
olfactory receptor family 7 subfamily D member 2
chr1_+_9943428 5.09 ENST00000403197.5
ENST00000377205.6
nicotinamide nucleotide adenylyltransferase 1
chrX_-_108736556 5.03 ENST00000372129.4
insulin receptor substrate 4
chr20_+_9514562 4.77 ENST00000246070.3
lysosomal associated membrane protein family member 5
chr9_-_76906041 4.54 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
prune homolog 2 with BCH domain
chr15_+_78438279 4.46 ENST00000560440.5
iron responsive element binding protein 2
chr1_-_207052980 4.45 ENST00000367084.1
YOD1 deubiquitinase
chr1_+_207053229 4.44 ENST00000367080.8
ENST00000367079.3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr6_-_32128191 4.35 ENST00000453203.2
ENST00000375203.8
ENST00000375201.8
activating transcription factor 6 beta
chr17_+_42458844 4.26 ENST00000393829.6
ENST00000537728.5
ENST00000343619.9
ENST00000264649.10
ENST00000585525.5
ENST00000544137.5
ENST00000589727.5
ENST00000587824.5
ATPase H+ transporting V0 subunit a1
chr2_+_54123179 4.25 ENST00000606865.1
acylphosphatase 2
chr16_+_6019016 4.19 ENST00000550418.6
RNA binding fox-1 homolog 1
chr6_+_160121859 4.12 ENST00000324965.8
ENST00000457470.6
solute carrier family 22 member 1
chr7_+_2519763 4.08 ENST00000222725.10
ENST00000359574.7
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr3_+_131026844 4.07 ENST00000510769.5
ENST00000383366.9
ENST00000510688.5
ENST00000511262.5
NIMA related kinase 11
chr19_+_57320461 3.95 ENST00000321545.5
zinc finger protein 543
chr11_-_129024157 3.80 ENST00000392657.7
Rho GTPase activating protein 32
chr11_+_24496988 3.80 ENST00000336930.11
leucine zipper protein 2
chr16_+_6019071 3.79 ENST00000547605.5
ENST00000553186.5
RNA binding fox-1 homolog 1
chr7_+_5879827 3.77 ENST00000416608.5
oncomodulin
chr6_+_160121809 3.66 ENST00000366963.9
solute carrier family 22 member 1
chr10_+_18260715 3.59 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
calcium voltage-gated channel auxiliary subunit beta 2
chr17_-_35063648 3.57 ENST00000394597.7
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr14_-_72894091 3.56 ENST00000556509.6
double PHD fingers 3
chr2_-_101308681 3.55 ENST00000295317.4
ring finger protein 149
chr2_+_165239432 3.55 ENST00000636071.2
ENST00000636985.2
sodium voltage-gated channel alpha subunit 2
chr14_-_24242600 3.50 ENST00000646753.1
ENST00000558566.1
ENST00000267415.12
ENST00000559019.1
ENST00000399423.8
ENST00000626689.2
TERF1 interacting nuclear factor 2
chr17_-_46579651 3.48 ENST00000573185.5
ENST00000570550.5
ENST00000445552.6
ENST00000329240.10
ENST00000622488.6
ENST00000336125.6
ADP ribosylation factor like GTPase 17A
chr7_+_26291850 3.45 ENST00000338523.9
ENST00000446848.6
sorting nexin 10
chr4_+_127632926 3.44 ENST00000335251.11
inturned planar cell polarity protein
chr15_+_78438199 3.40 ENST00000258886.13
iron responsive element binding protein 2
chr22_+_30396991 3.39 ENST00000617837.4
ENST00000615189.5
ENST00000405717.7
ENST00000402592.7
SEC14 like lipid binding 2
chr8_+_27311471 3.38 ENST00000397501.5
protein tyrosine kinase 2 beta
chr19_+_54137740 3.33 ENST00000644245.1
ENST00000646002.1
ENST00000221232.11
ENST00000440571.6
ENST00000617930.2
CCR4-NOT transcription complex subunit 3
chr3_-_105869035 3.26 ENST00000447441.6
ENST00000403724.5
ENST00000405772.5
Cbl proto-oncogene B
chr12_-_11395556 3.24 ENST00000565533.1
ENST00000389362.6
ENST00000546254.3
proline rich protein BstNI subfamily 2
proline rich protein BstNI subfamily 1
chr14_+_32329256 3.21 ENST00000280979.9
A-kinase anchoring protein 6
chr16_+_590056 3.18 ENST00000248139.8
ENST00000568586.5
ENST00000538492.5
RAB40C, member RAS oncogene family
chr1_-_51331315 3.11 ENST00000262676.9
tetratricopeptide repeat domain 39A
chr14_+_69398683 3.07 ENST00000556605.5
ENST00000031146.8
ENST00000336643.10
solute carrier family 39 member 9
chr3_-_44477639 3.03 ENST00000396077.8
zinc finger protein 445
chr2_+_113059194 2.99 ENST00000393200.7
interleukin 36 receptor antagonist
chr8_-_85341659 2.95 ENST00000522389.5
carbonic anhydrase 1
chr19_+_49527988 2.93 ENST00000270645.8
reticulocalbin 3
chr2_+_165239388 2.89 ENST00000424833.5
ENST00000375437.7
ENST00000631182.3
sodium voltage-gated channel alpha subunit 2
chr1_-_92486916 2.88 ENST00000294702.6
growth factor independent 1 transcriptional repressor
chr4_+_94974984 2.88 ENST00000672698.1
bone morphogenetic protein receptor type 1B
chr8_-_17722217 2.87 ENST00000381861.7
microtubule associated scaffold protein 1
chr19_-_14848922 2.82 ENST00000641129.1
olfactory receptor family 7 subfamily A member 10
chr15_+_62561361 2.81 ENST00000561311.5
talin 2
chr8_-_85341705 2.78 ENST00000517618.5
carbonic anhydrase 1
chrX_+_139530730 2.76 ENST00000218099.7
coagulation factor IX
chr3_-_131026726 2.72 ENST00000514044.5
ENST00000264992.8
asteroid homolog 1
chr6_-_110179995 2.70 ENST00000392586.5
ENST00000419252.1
ENST00000359451.6
ENST00000392588.5
WASP family member 1
chr2_+_113058637 2.67 ENST00000346807.7
interleukin 36 receptor antagonist
chr18_-_24311495 2.65 ENST00000357041.8
oxysterol binding protein like 1A
chr9_+_128149447 2.64 ENST00000277480.7
ENST00000372998.1
lipocalin 2
chr11_-_120120880 2.60 ENST00000526881.1
tripartite motif containing 29
chr4_-_145180496 2.58 ENST00000447906.8
OTU deubiquitinase 4
chr3_-_39280021 2.55 ENST00000399220.3
C-X3-C motif chemokine receptor 1
chr6_+_26204552 2.54 ENST00000615164.2
H4 clustered histone 5
chr13_-_109786567 2.52 ENST00000375856.5
insulin receptor substrate 2
chr17_-_64130813 2.48 ENST00000606895.2
endoplasmic reticulum to nucleus signaling 1
chr17_-_46361718 2.45 ENST00000575960.5
ENST00000575698.5
ENST00000571246.5
ENST00000434041.6
ENST00000656849.1
ENST00000570618.5
ENST00000450673.4
ENST00000622877.4
ADP ribosylation factor like GTPase 17B
chr12_-_118359105 2.43 ENST00000541186.5
ENST00000539872.5
TAO kinase 3
chr1_+_15236509 2.34 ENST00000683790.1
forkhead associated phosphopeptide binding domain 1
chr1_+_197268222 2.34 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
crumbs cell polarity complex component 1
chr2_-_169031317 2.31 ENST00000650372.1
ATP binding cassette subfamily B member 11
chr3_-_161105224 2.27 ENST00000651254.1
ENST00000651178.1
ENST00000476999.6
ENST00000652596.1
ENST00000651305.1
ENST00000652111.1
ENST00000651292.1
ENST00000651282.1
ENST00000651380.1
ENST00000494173.7
ENST00000484127.5
ENST00000650733.1
ENST00000494818.6
ENST00000492353.5
ENST00000652143.1
ENST00000473142.5
ENST00000651147.1
ENST00000468268.5
ENST00000460353.2
ENST00000651953.1
ENST00000651972.1
ENST00000652730.1
ENST00000651460.1
ENST00000652059.1
ENST00000651509.1
ENST00000651801.1
ENST00000651686.1
ENST00000320474.10
ENST00000392781.7
ENST00000392779.6
ENST00000651791.1
ENST00000651117.1
ENST00000652032.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr9_-_5339874 2.27 ENST00000223862.2
relaxin 1
chr11_+_94973640 2.25 ENST00000335080.6
ENST00000536741.1
lysine demethylase 4D
chr14_+_61187544 2.20 ENST00000555185.5
ENST00000557294.5
ENST00000556778.5
protein kinase C eta
chr5_-_22853320 2.19 ENST00000504376.6
ENST00000382254.6
cadherin 12
chr1_-_51330527 2.16 ENST00000439482.6
tetratricopeptide repeat domain 39A
chr12_+_93677556 2.15 ENST00000542893.2
CASP2 and RIPK1 domain containing adaptor with death domain
chr12_-_7936177 2.14 ENST00000544291.1
ENST00000075120.12
solute carrier family 2 member 3
chr12_+_6310669 2.14 ENST00000684764.1
pleckstrin homology and RhoGEF domain containing G6
chr6_+_26045374 2.10 ENST00000612966.3
H3 clustered histone 3
chr3_-_151329539 2.07 ENST00000325602.6
purinergic receptor P2Y13
chr11_-_60183011 2.07 ENST00000533023.5
ENST00000420732.6
ENST00000528851.6
membrane spanning 4-domains A6A
chrX_-_6535118 2.06 ENST00000381089.7
ENST00000612369.4
ENST00000398729.1
variable charge X-linked 3A
chr8_-_42768602 2.04 ENST00000534622.5
cholinergic receptor nicotinic alpha 6 subunit
chr14_+_32329341 2.03 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
A-kinase anchoring protein 6
chr14_+_94174334 2.01 ENST00000328839.3
protein phosphatase 4 regulatory subunit 4
chr4_-_99290975 2.01 ENST00000209668.3
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr12_-_122716790 2.00 ENST00000528880.3
hydroxycarboxylic acid receptor 3
chr6_-_169250825 1.98 ENST00000676869.1
ENST00000676760.1
thrombospondin 2
chr12_+_20695553 1.98 ENST00000545102.1
solute carrier organic anion transporter family member 1C1
chr5_+_129748091 1.95 ENST00000564719.2
membrane integral NOTCH2 associated receptor 2
chrX_+_15749848 1.93 ENST00000479740.5
ENST00000454127.2
carbonic anhydrase 5B
chr18_-_46964408 1.92 ENST00000676383.1
elongin A3 family member D
chr2_+_199955770 1.90 ENST00000435773.2
matrix AAA peptidase interacting protein 1
chr12_+_18261511 1.88 ENST00000538779.6
ENST00000433979.6
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr5_-_34043205 1.86 ENST00000382065.8
ENST00000231338.7
C1q and TNF related 3
chr2_+_90038848 1.85 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr11_-_84317296 1.81 ENST00000280241.12
ENST00000398301.6
discs large MAGUK scaffold protein 2
chr2_+_88885397 1.80 ENST00000390243.2
immunoglobulin kappa variable 4-1
chr11_-_60183191 1.79 ENST00000412309.6
membrane spanning 4-domains A6A
chr11_+_24497155 1.75 ENST00000529015.5
ENST00000533227.5
leucine zipper protein 2
chr4_+_37453914 1.74 ENST00000381980.9
ENST00000508175.5
chromosome 4 open reading frame 19
chr2_-_119525301 1.72 ENST00000627145.1
secretin receptor
chr1_-_248277976 1.69 ENST00000641220.1
olfactory receptor family 2 subfamily T member 33
chr2_-_119524483 1.66 ENST00000019103.8
secretin receptor
chr3_-_161105399 1.66 ENST00000652593.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr14_+_94174284 1.65 ENST00000304338.8
protein phosphatase 4 regulatory subunit 4
chr1_-_1778399 1.63 ENST00000341426.9
NAD kinase
chr1_+_197268204 1.61 ENST00000535699.5
ENST00000538660.5
crumbs cell polarity complex component 1
chr3_+_122183664 1.60 ENST00000639785.2
calcium sensing receptor
chr12_-_122703346 1.60 ENST00000328880.6
hydroxycarboxylic acid receptor 2
chr2_+_233671879 1.59 ENST00000354728.5
UDP glucuronosyltransferase family 1 member A9
chr2_-_165203870 1.58 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
sodium voltage-gated channel alpha subunit 3
chr3_-_161105070 1.57 ENST00000651430.1
ENST00000650695.1
ENST00000651689.1
ENST00000651916.1
ENST00000488170.5
ENST00000652377.1
ENST00000652669.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr21_-_36542600 1.56 ENST00000399136.5
claudin 14
chr7_-_100167284 1.47 ENST00000413800.5
galactose-3-O-sulfotransferase 4
chr11_-_118264282 1.45 ENST00000278937.7
myelin protein zero like 2
chr1_-_1778790 1.44 ENST00000341991.7
NAD kinase
chr21_-_14546297 1.44 ENST00000400566.6
ENST00000400564.5
SAM domain, SH3 domain and nuclear localization signals 1
chr11_+_2301987 1.44 ENST00000612299.4
ENST00000182290.9
tetraspanin 32
chr1_+_174700413 1.41 ENST00000529145.6
ENST00000325589.9
RAB GTPase activating protein 1 like
chr12_-_23584600 1.41 ENST00000396007.6
SRY-box transcription factor 5
chr12_-_52652207 1.40 ENST00000309680.4
keratin 2
chrX_+_37349287 1.40 ENST00000466533.5
ENST00000542554.5
ENST00000543642.5
ENST00000484460.5
ENST00000378628.9
ENST00000449135.6
ENST00000463135.1
ENST00000465127.1
proline rich and Gla domain 1
novel proline rich Gla (G-carboxyglutamic acid) 1 (PRRG1) and tetraspanin 7 (TSPAN7) protein
chr7_+_143954844 1.37 ENST00000641412.1
olfactory receptor family 2 subfamily F member 1
chr11_+_17260353 1.37 ENST00000530527.5
nucleobindin 2
chr1_+_160190567 1.34 ENST00000368078.8
calsequestrin 1
chr5_-_32444722 1.33 ENST00000265069.13
zinc finger RNA binding protein
chr2_+_29113989 1.33 ENST00000404424.5
CAP-Gly domain containing linker protein family member 4
chr1_+_15617415 1.31 ENST00000480945.6
DNA damage inducible 1 homolog 2
chr2_+_64988469 1.30 ENST00000531327.5
solute carrier family 1 member 4
chr6_+_110180418 1.27 ENST00000368930.5
ENST00000307731.2
cell division cycle 40
chr6_-_110815408 1.25 ENST00000368911.8
cyclin dependent kinase 19
chr1_-_51330553 1.24 ENST00000680483.1
ENST00000371747.7
tetratricopeptide repeat domain 39A
chr15_-_78234513 1.24 ENST00000558130.1
ENST00000258873.9
acyl-CoA synthetase bubblegum family member 1
chr20_-_45972171 1.24 ENST00000322927.3
zinc finger protein 335
chr7_-_135211313 1.22 ENST00000682802.1
ENST00000683848.1
ENST00000354475.5
WD repeat domain 91
chr2_-_88861258 1.21 ENST00000390240.2
immunoglobulin kappa joining 3
chr8_+_49911396 1.19 ENST00000642720.2
syntrophin gamma 1
chr12_+_119668109 1.18 ENST00000229328.10
ENST00000630317.1
protein kinase AMP-activated non-catalytic subunit beta 1
chr14_+_100019375 1.17 ENST00000544450.6
Enah/Vasp-like
chr16_-_29505820 1.16 ENST00000550665.5
nuclear pore complex interacting protein family member B12
chr17_-_42185452 1.16 ENST00000293330.1
hypocretin neuropeptide precursor
chr6_+_150368892 1.15 ENST00000229447.9
ENST00000392256.6
iodotyrosine deiodinase
chrX_+_136648214 1.13 ENST00000370628.2
CD40 ligand
chr6_+_29461440 1.13 ENST00000396792.2
olfactory receptor family 2 subfamily H member 1
chr1_-_13285154 1.12 ENST00000357367.6
ENST00000614831.1
PRAME family member 8
chr12_-_91058016 1.02 ENST00000266719.4
keratocan
chr1_-_66801276 1.00 ENST00000304526.3
insulin like 5
chr16_+_48244264 0.99 ENST00000285737.9
lon peptidase 2, peroxisomal
chr1_+_192636121 0.98 ENST00000543215.5
ENST00000391995.7
regulator of G protein signaling 13
chr14_+_20781139 0.98 ENST00000304677.3
ribonuclease A family member k6
chr11_+_15073562 0.96 ENST00000533448.1
ENST00000324229.11
calcitonin related polypeptide beta
chr2_+_48314637 0.95 ENST00000413569.5
ENST00000340553.8
forkhead box N2
chr2_+_137964446 0.93 ENST00000280096.5
ENST00000280097.5
histamine N-methyltransferase
chr3_-_165078480 0.92 ENST00000264382.8
sucrase-isomaltase
chr11_+_65787056 0.92 ENST00000335987.8
ovo like transcriptional repressor 1
chr3_+_122055355 0.91 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86 molecule
chr5_+_149357999 0.91 ENST00000274569.9
prenylcysteine oxidase 1 like
chr16_-_28363508 0.90 ENST00000532254.1
nuclear pore complex interacting protein family member B6
chr22_+_22811737 0.90 ENST00000390315.3
immunoglobulin lambda variable 3-10
chr12_-_118359639 0.90 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr19_-_5286163 0.90 ENST00000592099.5
ENST00000588012.5
ENST00000262963.10
ENST00000587303.5
ENST00000590509.5
protein tyrosine phosphatase receptor type S
chr2_+_233636445 0.84 ENST00000344644.9
UDP glucuronosyltransferase family 1 member A10
chr3_-_151316795 0.81 ENST00000260843.5
G protein-coupled receptor 87
chr16_-_29404029 0.81 ENST00000524087.5
nuclear pore complex interacting protein family member B11
chr16_+_50696999 0.79 ENST00000300589.6
nucleotide binding oligomerization domain containing 2
chr3_+_43690928 0.79 ENST00000644371.2
abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
chr22_+_22720615 0.78 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr21_-_26051023 0.78 ENST00000415997.1
amyloid beta precursor protein
chr8_+_49911604 0.78 ENST00000642164.1
ENST00000644093.1
ENST00000643999.1
ENST00000647073.1
ENST00000646880.1
syntrophin gamma 1
chr2_+_233636502 0.77 ENST00000373445.1
UDP glucuronosyltransferase family 1 member A10
chr17_+_46295099 0.75 ENST00000393465.7
ENST00000320254.5
leucine rich repeat containing 37A
chr2_+_137964279 0.75 ENST00000329366.8
histamine N-methyltransferase
chr16_+_28638065 0.73 ENST00000683297.1
nuclear pore complex interacting protein family member B8
chr11_-_63608542 0.73 ENST00000540943.1
phospholipase A and acyltransferase 3
chr10_-_114144599 0.72 ENST00000428953.1
coiled-coil domain containing 186
chr3_-_105868964 0.72 ENST00000394030.8
Cbl proto-oncogene B
chr16_+_11965234 0.72 ENST00000562385.1
TNF receptor superfamily member 17
chr6_-_25042003 0.71 ENST00000510784.8
RHO family interacting cell polarization regulator 2
chr16_+_31873772 0.70 ENST00000394846.7
ENST00000300870.15
zinc finger protein 267
chr17_-_10469558 0.66 ENST00000255381.2
myosin heavy chain 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
2.3 6.9 GO:0060903 positive regulation of meiosis I(GO:0060903)
2.1 20.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.0 5.9 GO:1902769 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
1.6 15.7 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.5 4.4 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
1.3 5.1 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
1.1 3.4 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
1.1 7.8 GO:0048241 epinephrine transport(GO:0048241)
1.0 2.9 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.9 3.5 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.9 5.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.8 4.1 GO:0007386 compartment pattern specification(GO:0007386)
0.8 5.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.7 4.4 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
0.7 8.7 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.7 2.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.7 3.6 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.7 5.7 GO:0019732 antifungal humoral response(GO:0019732)
0.6 2.5 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.6 3.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.6 2.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.6 2.3 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.5 6.4 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.5 2.6 GO:0015688 response to mycotoxin(GO:0010046) iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.5 3.6 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.5 2.5 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.5 3.2 GO:0051552 flavone metabolic process(GO:0051552)
0.4 0.9 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.4 2.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.4 2.9 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.4 2.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.4 1.4 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.4 2.5 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.3 3.5 GO:0070162 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.3 4.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.3 4.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 2.8 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.3 0.9 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.3 0.9 GO:0002665 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.3 0.9 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.3 4.0 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.3 1.7 GO:0052805 histamine metabolic process(GO:0001692) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.3 1.9 GO:0015811 L-cystine transport(GO:0015811)
0.2 5.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 1.9 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 1.4 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.2 6.4 GO:0035640 exploration behavior(GO:0035640)
0.2 0.8 GO:0035419 detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 0.8 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.2 2.1 GO:0006069 ethanol oxidation(GO:0006069)
0.2 4.7 GO:0034453 microtubule anchoring(GO:0034453)
0.2 3.9 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.2 1.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 2.0 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 12.4 GO:0007032 endosome organization(GO:0007032)
0.2 0.6 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 3.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 2.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 1.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.2 6.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 2.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 1.3 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 7.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 3.7 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 9.4 GO:0046677 response to antibiotic(GO:0046677)
0.1 12.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.0 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 3.1 GO:0006829 zinc II ion transport(GO:0006829)
0.1 6.0 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.1 0.6 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.1 3.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 8.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.8 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 1.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 1.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.0 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.1 1.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 0.5 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 1.2 GO:0035878 nail development(GO:0035878)
0.1 2.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 2.0 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 6.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 2.6 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 1.9 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 1.0 GO:0051546 keratinocyte migration(GO:0051546)
0.1 0.5 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.1 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 8.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 4.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.8 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 1.6 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 5.5 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.0 3.4 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 1.6 GO:0019228 neuronal action potential(GO:0019228)
0.0 2.3 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 1.4 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 1.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.3 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.4 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.2 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.3 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 1.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 2.1 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 4.3 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 2.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.0 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 1.3 GO:0009311 oligosaccharide metabolic process(GO:0009311)
0.0 3.5 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 1.6 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.8 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 1.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 1.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 2.4 GO:0007565 female pregnancy(GO:0007565)
0.0 0.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.9 GO:0071546 pi-body(GO:0071546)
0.8 2.5 GO:1990597 AIP1-IRE1 complex(GO:1990597)
0.8 4.8 GO:0032584 growth cone membrane(GO:0032584)
0.7 5.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.5 5.4 GO:0043203 axon hillock(GO:0043203)
0.5 3.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.4 3.5 GO:0070187 telosome(GO:0070187)
0.4 4.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4 6.4 GO:0033270 paranode region of axon(GO:0033270)
0.4 20.9 GO:0031430 M band(GO:0031430)
0.4 6.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 3.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 1.3 GO:0014802 terminal cisterna(GO:0014802)
0.3 6.1 GO:0044295 axonal growth cone(GO:0044295)
0.2 3.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 9.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 2.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 2.7 GO:0031209 SCAR complex(GO:0031209)
0.2 2.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 3.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 2.0 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.5 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 4.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 3.6 GO:0071565 nBAF complex(GO:0071565)
0.1 3.7 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.1 2.5 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 1.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 2.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.7 GO:0060171 stereocilium membrane(GO:0060171)
0.1 5.7 GO:0005902 microvillus(GO:0005902)
0.1 0.5 GO:0070852 cell body fiber(GO:0070852)
0.1 2.3 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.6 GO:0000813 ESCRT I complex(GO:0000813)
0.1 1.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.9 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 4.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 3.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 10.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.6 GO:0016592 mediator complex(GO:0016592)
0.0 3.4 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.7 GO:0032982 myosin filament(GO:0032982)
0.0 4.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.4 GO:0008305 integrin complex(GO:0008305)
0.0 8.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.1 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.0 2.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 11.7 GO:0043025 neuronal cell body(GO:0043025)
0.0 6.3 GO:0005911 cell-cell junction(GO:0005911)
0.0 3.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.5 GO:0072562 blood microparticle(GO:0072562)
0.0 4.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 11.6 GO:0005615 extracellular space(GO:0005615)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 17.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
2.6 7.9 GO:0030350 iron-responsive element binding(GO:0030350)
1.9 7.8 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
1.5 4.4 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
1.3 5.1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
1.1 5.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
1.1 3.4 GO:0008431 vitamin E binding(GO:0008431)
1.1 15.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.1 5.5 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
1.0 4.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.7 4.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.7 2.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.7 4.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.6 2.5 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.6 1.8 GO:0005174 CD40 receptor binding(GO:0005174)
0.6 5.7 GO:0004064 arylesterase activity(GO:0004064)
0.4 1.3 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.4 6.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.4 7.0 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.4 2.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.3 5.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 20.9 GO:0030507 spectrin binding(GO:0030507)
0.3 3.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.3 3.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.3 1.9 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.3 2.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 4.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 7.5 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.3 8.0 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 2.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 0.6 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 1.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 0.9 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 5.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 3.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 0.5 GO:0030290 sphingolipid activator protein activity(GO:0030290) beta-N-acetylgalactosaminidase activity(GO:0032428)
0.2 3.2 GO:0035497 cAMP response element binding(GO:0035497)
0.2 2.9 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 9.3 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.9 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 4.7 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 12.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 6.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 2.1 GO:0070513 death domain binding(GO:0070513)
0.1 2.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 1.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 9.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 3.1 GO:0003951 NAD+ kinase activity(GO:0003951)
0.1 5.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 3.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 3.4 GO:0001972 retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020)
0.1 0.8 GO:0051425 PTB domain binding(GO:0051425)
0.1 1.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 2.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 3.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 2.6 GO:0015248 sterol transporter activity(GO:0015248)
0.1 2.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 5.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.8 GO:0050700 CARD domain binding(GO:0050700)
0.1 11.3 GO:0002020 protease binding(GO:0002020)
0.1 1.2 GO:0005522 profilin binding(GO:0005522)
0.1 0.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 6.1 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.3 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 2.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.5 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 3.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 2.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 1.7 GO:0043022 ribosome binding(GO:0043022)
0.0 8.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.7 GO:0051117 ATPase binding(GO:0051117)
0.0 22.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.7 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 2.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.9 GO:0015026 coreceptor activity(GO:0015026)
0.0 4.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.8 GO:0051015 actin filament binding(GO:0051015)
0.0 1.0 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.7 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 3.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.3 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.4 GO:0004518 nuclease activity(GO:0004518)
0.0 1.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 7.5 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 3.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 3.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 5.8 PID CD40 PATHWAY CD40/CD40L signaling
0.1 7.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 3.6 PID TNF PATHWAY TNF receptor signaling pathway
0.1 1.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 2.9 PID BMP PATHWAY BMP receptor signaling
0.1 2.1 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 13.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 3.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 5.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 3.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.2 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.8 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 2.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.6 PID ARF 3PATHWAY Arf1 pathway
0.0 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 7.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.0 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 1.9 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 19.0 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.7 9.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.6 9.7 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.5 7.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.4 3.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.2 17.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 2.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 2.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 4.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 6.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 2.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 12.3 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 4.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 2.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 4.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 3.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 3.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.4 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 0.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 4.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 0.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 5.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 12.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 1.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 3.4 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.1 1.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.9 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.6 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 2.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.8 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 1.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 8.2 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.8 REACTOME UNFOLDED PROTEIN RESPONSE Genes involved in Unfolded Protein Response
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis