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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXB4_LHX9

Z-value: 3.05

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Transcription factors associated with HOXB4_LHX9

Gene Symbol Gene ID Gene Info
ENSG00000182742.6 HOXB4
ENSG00000143355.16 LHX9

Activity profile of HOXB4_LHX9 motif

Sorted Z-values of HOXB4_LHX9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB4_LHX9

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_+_168497066 23.85 ENST00000261509.10
palladin, cytoskeletal associated protein
chr4_+_168497044 20.59 ENST00000505667.6
palladin, cytoskeletal associated protein
chr15_-_72231583 18.41 ENST00000566809.1
ENST00000567087.5
ENST00000569050.1
ENST00000568883.5
pyruvate kinase M1/2
chr14_+_34993240 16.51 ENST00000677647.1
signal recognition particle 54
chr15_-_60398733 15.51 ENST00000559818.6
annexin A2
chr7_-_88226987 14.87 ENST00000394641.7
sorcin
chr7_-_88226965 14.82 ENST00000490437.5
ENST00000431660.5
sorcin
chr14_+_61697622 14.41 ENST00000539097.2
hypoxia inducible factor 1 subunit alpha
chr3_-_64019334 14.05 ENST00000480205.5
proteasome 26S subunit, non-ATPase 6
chr6_-_38703066 13.26 ENST00000373365.5
glyoxalase I
chr17_+_68515399 12.56 ENST00000588188.6
protein kinase cAMP-dependent type I regulatory subunit alpha
chr7_+_141738321 12.52 ENST00000612337.4
single stranded DNA binding protein 1
chr5_+_154941063 12.20 ENST00000523037.6
ENST00000265229.12
ENST00000439747.7
ENST00000522038.5
mitochondrial ribosomal protein L22
chr15_-_60397964 11.82 ENST00000558998.5
ENST00000560165.5
ENST00000557986.5
ENST00000559467.5
ENST00000677968.1
ENST00000678450.1
ENST00000332680.8
ENST00000396024.7
ENST00000557906.6
ENST00000558558.6
ENST00000559113.6
ENST00000559780.6
ENST00000559956.6
ENST00000560468.6
ENST00000678870.1
ENST00000678061.1
ENST00000451270.7
ENST00000421017.6
ENST00000560466.5
ENST00000558132.5
ENST00000559370.5
ENST00000559725.5
ENST00000558985.6
ENST00000679109.1
annexin A2
chr18_-_36798482 11.59 ENST00000590258.2
tubulin polyglutamylase complex subunit 2
chr11_-_107858777 10.69 ENST00000525815.6
solute carrier family 35 member F2
chr4_-_102828022 10.62 ENST00000502690.5
ubiquitin conjugating enzyme E2 D3
chr17_+_47651061 10.31 ENST00000540627.5
karyopherin subunit beta 1
chr6_+_113857333 9.97 ENST00000612661.2
myristoylated alanine rich protein kinase C substrate
chr3_+_158801926 9.48 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
major facilitator superfamily domain containing 1
chr3_+_138621225 9.17 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr12_+_64404338 8.87 ENST00000332707.10
exportin for tRNA
chr9_+_69145463 8.84 ENST00000636438.1
tight junction protein 2
chr4_-_102828048 8.46 ENST00000508249.1
ubiquitin conjugating enzyme E2 D3
chrX_-_16869840 8.24 ENST00000380084.8
RB binding protein 7, chromatin remodeling factor
chr2_+_101839815 7.10 ENST00000421882.5
mitogen-activated protein kinase kinase kinase kinase 4
chr1_-_212791762 7.08 ENST00000626725.1
ENST00000366977.8
ENST00000366976.3
NSL1 component of MIS12 kinetochore complex
chr7_+_141738343 7.06 ENST00000498107.5
ENST00000265304.11
ENST00000467681.5
ENST00000465582.5
ENST00000463093.5
single stranded DNA binding protein 1
chr3_+_138621207 6.99 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr5_-_126595237 6.85 ENST00000637206.1
ENST00000553117.5
aldehyde dehydrogenase 7 family member A1
chr3_+_23810436 6.84 ENST00000467766.5
ENST00000424381.5
ubiquitin conjugating enzyme E2 E1
chr1_-_197146620 6.71 ENST00000367409.9
ENST00000680265.1
assembly factor for spindle microtubules
chr11_-_63608542 6.54 ENST00000540943.1
phospholipase A and acyltransferase 3
chr5_-_177462379 6.53 ENST00000512501.1
drebrin 1
chr14_-_106470788 6.51 ENST00000434710.1
immunoglobulin heavy variable 3-43
chr4_+_112647059 6.51 ENST00000511529.1
La ribonucleoprotein 7, transcriptional regulator
chr13_+_30422487 6.48 ENST00000638137.1
ENST00000635918.2
ubiquitin conjugating enzyme E2 L5
chr11_-_11353241 6.46 ENST00000528848.3
casein kinase 2 alpha 3
chrX_+_101408198 6.32 ENST00000316594.6
heterogeneous nuclear ribonucleoprotein H2
chr8_-_89984231 6.31 ENST00000517337.1
ENST00000409330.5
nibrin
chr8_-_89984609 6.19 ENST00000519426.5
ENST00000265433.8
nibrin
chr17_+_50746614 5.89 ENST00000513969.5
ENST00000503728.1
LUC7 like 3 pre-mRNA splicing factor
chr17_+_50746534 5.85 ENST00000511974.5
LUC7 like 3 pre-mRNA splicing factor
chr20_-_1466904 5.83 ENST00000476071.5
NSFL1 cofactor
chr21_-_29061351 5.82 ENST00000432178.5
chaperonin containing TCP1 subunit 8
chr18_+_58341038 5.55 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chrX_-_101407893 5.48 ENST00000676156.1
ENST00000675592.1
ENST00000674634.2
ENST00000649178.1
ENST00000218516.4
galactosidase alpha
chr20_-_1466822 5.28 ENST00000353088.6
ENST00000216879.9
NSFL1 cofactor
chr2_-_74392025 5.07 ENST00000440727.1
ENST00000409240.5
dynactin subunit 1
chr1_+_155308748 5.06 ENST00000611010.4
ENST00000447866.5
ENST00000368356.9
ENST00000467076.5
ENST00000491013.5
ENST00000356657.10
farnesyl diphosphate synthase
chr2_+_27663880 4.99 ENST00000618046.4
ENST00000613517.4
solute carrier family 4 member 1 adaptor protein
chr15_+_64387828 4.96 ENST00000261884.8
thyroid hormone receptor interactor 4
chr3_-_149377637 4.88 ENST00000305366.8
transmembrane 4 L six family member 1
chr1_+_155308930 4.79 ENST00000465559.5
ENST00000612683.1
farnesyl diphosphate synthase
chr17_+_68249200 4.79 ENST00000577985.5
archaelysin family metallopeptidase 2
chr7_+_116222804 4.69 ENST00000393481.6
testin LIM domain protein
chr12_+_49227874 4.66 ENST00000541364.5
tubulin alpha 1c
chr13_-_23433676 4.65 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
sacsin molecular chaperone
chr13_-_23433735 4.59 ENST00000423156.2
ENST00000683210.1
ENST00000682775.1
ENST00000684497.1
ENST00000682944.1
ENST00000683489.1
ENST00000684385.1
ENST00000683680.1
sacsin molecular chaperone
chr20_+_19886506 4.58 ENST00000648440.1
Ras and Rab interactor 2
chr3_+_148991408 4.46 ENST00000627418.2
ENST00000296048.10
ENST00000483267.5
ENST00000345003.9
ENST00000484197.5
glycogenin 1
chr20_-_44504850 4.37 ENST00000411544.5
serine incorporator 3
chr4_-_102828159 4.32 ENST00000394803.9
ubiquitin conjugating enzyme E2 D3
chr18_-_49492305 4.18 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
ribosomal protein L17
RPL17-C18orf32 readthrough
chr4_-_102827723 4.10 ENST00000349311.12
ubiquitin conjugating enzyme E2 D3
chr2_-_89085787 4.09 ENST00000390252.2
immunoglobulin kappa variable 3-15
chr4_-_102827948 4.07 ENST00000394804.6
ENST00000394801.8
ubiquitin conjugating enzyme E2 D3
chr1_-_197146688 4.06 ENST00000294732.11
assembly factor for spindle microtubules
chr11_-_95923763 4.06 ENST00000497683.6
ENST00000470293.6
ENST00000674968.1
ENST00000484818.6
ENST00000675454.1
ENST00000675981.1
ENST00000674924.1
ENST00000676166.1
ENST00000676440.1
ENST00000675807.1
ENST00000495134.6
ENST00000675196.1
myotubularin related protein 2
chr2_+_218245426 4.02 ENST00000456575.1
actin related protein 2/3 complex subunit 2
chr5_+_65926556 3.91 ENST00000380943.6
ENST00000416865.6
ENST00000380935.5
ENST00000284037.10
erbb2 interacting protein
chr11_+_35180279 3.91 ENST00000531873.5
CD44 molecule (Indian blood group)
chr6_+_63521738 3.90 ENST00000648894.1
ENST00000639568.2
protein tyrosine phosphatase 4A1
chr12_-_56741535 3.83 ENST00000647707.1
novel protein
chr2_+_86907953 3.70 ENST00000409776.6
RANBP2 like and GRIP domain containing 1
chr13_-_30464234 3.65 ENST00000399489.5
ENST00000339872.8
high mobility group box 1
chr2_+_27663441 3.58 ENST00000326019.10
ENST00000613058.4
solute carrier family 4 member 1 adaptor protein
chr6_+_30720335 3.55 ENST00000327892.13
tubulin beta class I
chr9_+_122370523 3.53 ENST00000643810.1
ENST00000540753.6
prostaglandin-endoperoxide synthase 1
chr2_+_186590022 3.51 ENST00000261023.8
ENST00000374907.7
integrin subunit alpha V
chr2_-_70293675 3.51 ENST00000454893.1
ENST00000272348.7
small nuclear ribonucleoprotein polypeptide G
chr20_+_45416551 3.50 ENST00000639292.1
phosphatidylinositol glycan anchor biosynthesis class T
chr15_-_34343112 3.47 ENST00000557912.1
ENST00000328848.6
NOP10 ribonucleoprotein
chr11_-_18526885 3.46 ENST00000251968.4
ENST00000536719.5
tumor susceptibility 101
chr3_+_136930469 3.45 ENST00000469404.1
ENST00000467911.1
NCK adaptor protein 1
chr6_-_82247697 3.44 ENST00000306270.12
ENST00000610980.4
inhibitor of Bruton tyrosine kinase
chr17_+_35587478 3.43 ENST00000618940.4
adaptor related protein complex 2 subunit beta 1
chr3_-_146528750 3.40 ENST00000483300.5
phospholipid scramblase 1
chrX_+_85003863 3.34 ENST00000373173.7
apolipoprotein O like
chr16_+_15395745 3.22 ENST00000287594.7
ENST00000396385.4
ENST00000568766.1
MPV17 mitochondrial inner membrane protein like
novel protein
chr1_-_88891496 3.22 ENST00000448623.5
ENST00000370500.10
ENST00000418217.1
general transcription factor IIB
chr3_-_142029108 3.21 ENST00000497579.5
transcription factor Dp-2
chr20_-_35147285 3.16 ENST00000374491.3
ENST00000374492.8
ER degradation enhancing alpha-mannosidase like protein 2
chr14_-_67412112 3.13 ENST00000216446.9
pleckstrin 2
chr1_-_154627945 3.13 ENST00000681683.1
ENST00000368471.8
ENST00000649042.1
ENST00000680270.1
ENST00000649022.2
ENST00000681056.1
ENST00000649724.1
adenosine deaminase RNA specific
chr17_+_35587239 3.08 ENST00000621914.4
ENST00000621668.4
ENST00000616681.4
ENST00000612035.4
ENST00000610402.5
ENST00000614600.4
ENST00000590432.5
ENST00000612116.5
adaptor related protein complex 2 subunit beta 1
chr7_-_22822829 3.08 ENST00000358435.9
ENST00000621567.1
translocase of outer mitochondrial membrane 7
chr7_-_22822779 3.07 ENST00000372879.8
translocase of outer mitochondrial membrane 7
chr14_-_103921494 3.06 ENST00000557040.5
ENST00000414262.6
ENST00000555030.5
ENST00000554713.2
ENST00000286953.8
ENST00000553430.5
ATP synthase membrane subunit j
chr2_-_74391837 3.05 ENST00000417090.1
ENST00000409868.5
ENST00000680606.1
dynactin subunit 1
chr3_+_139344530 2.89 ENST00000478464.5
mitochondrial ribosomal protein S22
chr20_+_58907981 2.88 ENST00000656419.1
GNAS complex locus
chr8_+_103298433 2.84 ENST00000522566.5
frizzled class receptor 6
chr8_-_48921419 2.75 ENST00000020945.4
snail family transcriptional repressor 2
chr3_-_125520165 2.75 ENST00000251775.9
sorting nexin 4
chr4_-_75724386 2.66 ENST00000677606.1
ENST00000678798.1
ENST00000677970.1
ENST00000677620.1
ENST00000679281.1
ENST00000677333.1
ENST00000676470.1
ENST00000499709.3
ENST00000511868.6
ENST00000678971.1
ENST00000677265.1
ENST00000677952.1
ENST00000678122.1
ENST00000678100.1
ENST00000678062.1
ENST00000676666.1
G3BP stress granule assembly factor 2
chr2_+_237085875 2.63 ENST00000392008.6
ENST00000409334.5
ENST00000354371.7
COP9 signalosome subunit 8
chr16_-_66730216 2.61 ENST00000569320.5
dynein cytoplasmic 1 light intermediate chain 2
chr7_+_107583919 2.58 ENST00000491150.5
B cell receptor associated protein 29
chr10_-_104085847 2.57 ENST00000648076.2
collagen type XVII alpha 1 chain
chr7_+_23106267 2.56 ENST00000409689.5
ENST00000410047.1
kelch like family member 7
chr6_+_36594354 2.56 ENST00000373715.11
serine and arginine rich splicing factor 3
chr14_+_35122722 2.50 ENST00000605870.5
ENST00000557404.3
protein only RNase P catalytic subunit
chr6_+_30617825 2.45 ENST00000259873.5
mitochondrial ribosomal protein S18B
chr2_-_206159410 2.42 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NADH:ubiquinone oxidoreductase core subunit S1
chr13_+_48037692 2.41 ENST00000258662.3
nudix hydrolase 15
chr7_-_87220567 2.36 ENST00000433078.5
transmembrane protein 243
chr15_-_19988117 2.33 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr11_+_57712574 2.24 ENST00000278422.9
ENST00000378312.8
thioredoxin related transmembrane protein 2
chr5_+_36151989 2.22 ENST00000274254.9
S-phase kinase associated protein 2
chr10_+_120851341 2.19 ENST00000263461.11
WD repeat domain 11
chr13_-_75366973 2.19 ENST00000648194.1
TBC1 domain family member 4
chr17_-_41586887 2.19 ENST00000167586.7
keratin 14
chr1_+_81306096 2.16 ENST00000370721.5
ENST00000370727.5
ENST00000370725.5
ENST00000370723.5
ENST00000370728.5
ENST00000370730.5
adhesion G protein-coupled receptor L2
chr2_+_233729042 2.15 ENST00000482026.6
UDP glucuronosyltransferase family 1 member A3
chr7_-_80919017 2.14 ENST00000265361.8
semaphorin 3C
chr6_-_53510445 2.13 ENST00000509541.5
glutamate-cysteine ligase catalytic subunit
chr1_-_23344314 2.11 ENST00000374612.5
ENST00000675048.1
ENST00000478691.5
heterogeneous nuclear ribonucleoprotein R
chr6_+_26365215 2.08 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr2_-_151289613 2.03 ENST00000243346.10
N-myc and STAT interactor
chr6_-_109381739 2.03 ENST00000504373.2
CD164 molecule
chr1_+_54715837 2.03 ENST00000371281.4
tetratricopeptide repeat domain 4
chr7_+_117014881 2.02 ENST00000422922.5
ENST00000432298.5
suppression of tumorigenicity 7
chr14_-_35121950 2.02 ENST00000554361.5
ENST00000261475.10
protein phosphatase 2 regulatory subunit B''gamma
chr11_-_95924067 1.96 ENST00000676027.1
ENST00000675489.1
ENST00000409459.5
ENST00000676261.1
ENST00000352297.11
ENST00000346299.10
ENST00000676272.1
ENST00000393223.8
ENST00000675022.1
ENST00000675362.1
ENST00000675174.1
ENST00000674989.1
ENST00000675848.1
ENST00000675652.1
ENST00000481642.6
myotubularin related protein 2
chr1_-_109041986 1.92 ENST00000400794.7
ENST00000528747.1
ENST00000361054.7
WD repeat domain 47
chr2_+_90172802 1.89 ENST00000390277.3
immunoglobulin kappa variable 3D-11
chr1_-_109042093 1.88 ENST00000369962.8
ENST00000357672.7
ENST00000531337.1
ENST00000529074.1
ENST00000369965.8
WD repeat domain 47
chrX_-_101617921 1.88 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
armadillo repeat containing X-linked 6
chr5_-_140346596 1.88 ENST00000230990.7
heparin binding EGF like growth factor
chr4_+_109815503 1.87 ENST00000394631.7
GAR1 ribonucleoprotein
chr4_-_39977836 1.87 ENST00000303538.13
ENST00000503396.5
PDS5 cohesin associated factor A
chr8_-_30812773 1.84 ENST00000221138.9
protein phosphatase 2 catalytic subunit beta
chr2_-_88979016 1.83 ENST00000390247.2
immunoglobulin kappa variable 3-7 (non-functional)
chr14_-_106593319 1.79 ENST00000390627.3
immunoglobulin heavy variable 3-53
chr1_-_66801276 1.79 ENST00000304526.3
insulin like 5
chr3_-_149576203 1.78 ENST00000472417.1
WW domain containing transcription regulator 1
chr20_+_63739751 1.77 ENST00000266077.5
SLC2A4 regulator
chr10_+_99732211 1.76 ENST00000370476.10
ENST00000370472.4
cutC copper transporter
chr1_-_23344259 1.73 ENST00000476451.2
ENST00000302271.11
ENST00000606561.5
ENST00000374616.7
heterogeneous nuclear ribonucleoprotein R
chr17_+_41966787 1.66 ENST00000393892.8
ENST00000587679.1
2',3'-cyclic nucleotide 3' phosphodiesterase
chr22_+_22375984 1.66 ENST00000390296.2
immunoglobulin lambda variable 5-45
chr2_+_132416795 1.60 ENST00000329321.4
G protein-coupled receptor 39
chr6_+_26365176 1.60 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr15_+_67125707 1.58 ENST00000540846.6
SMAD family member 3
chr4_+_168631597 1.56 ENST00000504519.5
ENST00000512127.5
palladin, cytoskeletal associated protein
chr2_+_90234809 1.54 ENST00000443397.5
immunoglobulin kappa variable 3D-7
chr1_-_13116854 1.52 ENST00000621994.3
heterogeneous nuclear ribonucleoprotein C like 2
chr5_+_90474848 1.51 ENST00000651687.1
RNA polymerase III subunit G
chrX_+_109535775 1.48 ENST00000218004.5
nuclear transport factor 2 like export factor 2
chr17_+_41966814 1.47 ENST00000393888.1
ENST00000441615.2
2',3'-cyclic nucleotide 3' phosphodiesterase
chr1_-_77219399 1.44 ENST00000359130.1
ENST00000370812.8
ENST00000445065.5
phosphatidylinositol glycan anchor biosynthesis class K
chr8_+_10095704 1.42 ENST00000382490.9
methionine sulfoxide reductase A
chr12_+_20810698 1.41 ENST00000540853.5
ENST00000381545.8
solute carrier organic anion transporter family member 1B3
chr5_+_90474879 1.40 ENST00000504930.5
ENST00000514483.5
RNA polymerase III subunit G
chr6_-_110179995 1.38 ENST00000392586.5
ENST00000419252.1
ENST00000359451.6
ENST00000392588.5
WASP family member 1
chr8_+_10095551 1.37 ENST00000522907.5
ENST00000528246.5
methionine sulfoxide reductase A
chr11_-_105035113 1.35 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
caspase 1
chr10_-_32935511 1.35 ENST00000423113.5
integrin subunit beta 1
chr5_+_179732811 1.28 ENST00000292599.4
mastermind like transcriptional coactivator 1
chr22_+_22811737 1.20 ENST00000390315.3
immunoglobulin lambda variable 3-10
chr3_+_44799187 1.13 ENST00000425755.5
kinesin family member 15
chr17_-_44066595 1.12 ENST00000585388.2
ENST00000293406.8
LSM12 homolog
chr18_-_3219849 1.09 ENST00000261606.11
myomesin 1
chr14_+_35122660 1.08 ENST00000603544.5
protein only RNase P catalytic subunit
chr3_-_165078480 1.08 ENST00000264382.8
sucrase-isomaltase
chr22_-_32255344 1.04 ENST00000266086.6
solute carrier family 5 member 4
chr5_-_16916400 1.04 ENST00000513882.5
myosin X
chr5_+_36152077 1.04 ENST00000546211.6
ENST00000620197.5
ENST00000678270.1
ENST00000679015.1
ENST00000678580.1
ENST00000274255.11
ENST00000508514.5
S-phase kinase associated protein 2
chr5_-_150449676 1.02 ENST00000312037.6
ribosomal protein S14
chr1_-_211134061 1.02 ENST00000639602.1
ENST00000638498.1
ENST00000367007.5
novel protein
potassium voltage-gated channel subfamily H member 1
chr13_+_35476740 1.00 ENST00000537702.5
neurobeachin
chr16_-_10942443 0.95 ENST00000570440.2
ENST00000331808.5
Dexi homolog
chr8_-_100559702 0.93 ENST00000520311.5
ENST00000520552.5
ENST00000521345.1
ENST00000523000.5
ENST00000335659.7
ENST00000358990.3
ENST00000519597.5
ankyrin repeat domain 46
chr5_-_150449731 0.91 ENST00000407193.7
ribosomal protein S14
chr15_+_89088417 0.90 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
abhydrolase domain containing 2, acylglycerol lipase
chr12_+_26195647 0.86 ENST00000535504.1
sarcospan
chr2_-_224947030 0.86 ENST00000409592.7
dedicator of cytokinesis 10
chrX_+_77910656 0.85 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr22_-_17774482 0.84 ENST00000399765.5
ENST00000614949.4
ENST00000399767.6
BH3 interacting domain death agonist
chr20_+_18507520 0.82 ENST00000336714.8
ENST00000646240.1
ENST00000450074.6
ENST00000262544.6
SEC23 homolog B, COPII coat complex component
chr21_-_26843012 0.82 ENST00000517777.6
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr14_+_23469681 0.81 ENST00000408901.8
ENST00000397154.7
ENST00000555128.5
neuroguidin
chr16_+_24537693 0.79 ENST00000564314.5
ENST00000567686.5
RB binding protein 6, ubiquitin ligase
chr19_-_6424802 0.78 ENST00000600480.2
KH-type splicing regulatory protein
chr6_-_52994248 0.78 ENST00000457564.1
ENST00000370960.5
glutathione S-transferase alpha 4
chr2_+_87338511 0.77 ENST00000421835.2
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr14_-_106211453 0.76 ENST00000390606.3
immunoglobulin heavy variable 3-20
chr18_-_55423757 0.69 ENST00000675707.1
transcription factor 4
chr17_-_39451243 0.69 ENST00000300651.11
ENST00000394287.7
mediator complex subunit 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 27.3 GO:0044111 development involved in symbiotic interaction(GO:0044111)
4.2 29.7 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
4.1 16.5 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
3.6 10.8 GO:0009786 regulation of asymmetric cell division(GO:0009786)
2.5 12.5 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
2.4 17.1 GO:0051541 elastin metabolic process(GO:0051541)
2.4 46.0 GO:0003334 keratinocyte development(GO:0003334)
2.3 18.4 GO:0042866 pyruvate biosynthetic process(GO:0042866)
2.3 6.9 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
2.2 13.3 GO:0009438 methylglyoxal metabolic process(GO:0009438)
2.1 10.3 GO:0031291 Ran protein signal transduction(GO:0031291)
2.0 9.9 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
1.8 5.3 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
1.6 8.2 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
1.4 19.6 GO:0051096 positive regulation of helicase activity(GO:0051096)
1.4 8.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
1.3 6.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
1.2 3.5 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
1.2 3.5 GO:2000397 ubiquitin-dependent endocytosis(GO:0070086) positive regulation of viral budding via host ESCRT complex(GO:1903774) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
1.2 3.5 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
1.1 8.8 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
1.1 6.5 GO:0010643 cell communication by chemical coupling(GO:0010643)
1.1 3.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
1.1 3.2 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
1.0 12.6 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.9 2.8 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.9 2.7 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
0.9 3.6 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.9 6.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.7 2.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.7 2.1 GO:0044752 response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.7 5.5 GO:0016139 glycoside catabolic process(GO:0016139)
0.7 6.2 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.7 2.0 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.7 6.0 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.6 4.9 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.6 28.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.6 2.9 GO:0070425 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433)
0.6 9.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.5 3.3 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.5 3.1 GO:1900368 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
0.5 5.6 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.5 1.4 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.4 3.6 GO:0009597 detection of virus(GO:0009597)
0.4 2.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.4 2.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.4 1.3 GO:0003162 atrioventricular node development(GO:0003162)
0.4 3.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.4 5.8 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.4 10.0 GO:0051764 actin crosslink formation(GO:0051764)
0.4 3.2 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.3 2.8 GO:0030091 protein repair(GO:0030091)
0.3 11.1 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.3 2.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 2.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 2.4 GO:0006203 dGTP catabolic process(GO:0006203)
0.3 3.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 1.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.3 3.3 GO:0042407 cristae formation(GO:0042407)
0.3 1.3 GO:0010710 regulation of collagen catabolic process(GO:0010710)
0.3 11.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 1.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.3 2.0 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.2 17.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 1.8 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.2 7.1 GO:0030033 microvillus assembly(GO:0030033)
0.2 1.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 0.6 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.2 4.0 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.2 1.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 0.6 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.2 8.9 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 2.9 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.2 2.2 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 2.6 GO:0000338 protein deneddylation(GO:0000338)
0.2 0.7 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) regulation of G0 to G1 transition(GO:0070316)
0.2 2.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 4.2 GO:0061157 mRNA destabilization(GO:0061157)
0.2 1.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 14.1 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.1 0.7 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 4.5 GO:0000272 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 5.0 GO:1901998 toxin transport(GO:1901998)
0.1 3.5 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 3.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 7.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 1.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 3.4 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 2.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 0.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 6.6 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902)
0.1 0.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 1.5 GO:0060347 heart trabecula formation(GO:0060347)
0.1 2.6 GO:0051642 centrosome localization(GO:0051642)
0.1 0.6 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 1.3 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 9.3 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.1 6.5 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.1 0.8 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 1.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 2.4 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.0 1.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.9 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.0 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 2.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 4.7 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 4.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 4.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 6.5 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.8 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 2.5 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 1.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.0 0.5 GO:0006833 water transport(GO:0006833)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 6.3 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 2.6 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.2 GO:0051028 mRNA transport(GO:0051028)
0.0 0.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.0 GO:0051919 positive regulation of fibrinolysis(GO:0051919)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 29.7 GO:0044326 dendritic spine neck(GO:0044326)
3.9 27.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
2.8 11.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)
1.8 16.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
1.3 4.0 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.2 4.9 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
1.2 10.8 GO:0036449 microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687)
1.2 7.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
1.2 3.5 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
1.1 12.5 GO:0030870 Mre11 complex(GO:0030870)
0.9 9.2 GO:0070852 cell body fiber(GO:0070852)
0.9 46.0 GO:0002102 podosome(GO:0002102)
0.8 6.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.8 5.3 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.7 15.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.7 2.1 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.6 12.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.6 8.1 GO:0005869 dynactin complex(GO:0005869)
0.6 3.3 GO:0061617 MICOS complex(GO:0061617)
0.5 2.4 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.5 14.1 GO:0005838 proteasome regulatory particle(GO:0005838)
0.5 1.4 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.4 1.3 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.4 5.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.4 3.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.4 6.6 GO:0043073 germ cell nucleus(GO:0043073)
0.4 10.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.4 3.5 GO:0000813 ESCRT I complex(GO:0000813)
0.4 19.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 8.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 3.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.3 3.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 12.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 3.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.3 6.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 6.5 GO:0030056 hemidesmosome(GO:0030056)
0.3 1.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.3 1.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.3 14.4 GO:1904115 axon cytoplasm(GO:1904115)
0.2 5.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 6.5 GO:0005921 gap junction(GO:0005921)
0.2 0.6 GO:0018444 translation release factor complex(GO:0018444)
0.2 3.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 5.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 3.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 9.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 1.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 0.7 GO:0035363 histone locus body(GO:0035363)
0.1 1.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 2.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 21.6 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 1.4 GO:0031209 SCAR complex(GO:0031209)
0.1 3.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.4 GO:0071920 cleavage body(GO:0071920)
0.1 0.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 2.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 3.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 8.9 GO:0005643 nuclear pore(GO:0005643)
0.1 1.9 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 0.5 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 3.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 2.6 GO:0045095 keratin filament(GO:0045095)
0.1 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 2.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 5.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 1.0 GO:0031527 filopodium membrane(GO:0031527)
0.1 5.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 2.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.2 GO:0005771 multivesicular body(GO:0005771)
0.0 0.6 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 23.4 GO:0010008 endosome membrane(GO:0010008)
0.0 4.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 6.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 3.2 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 13.5 GO:0005874 microtubule(GO:0005874)
0.0 3.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 12.2 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 0.8 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 1.8 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 27.3 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
4.6 18.4 GO:0004743 pyruvate kinase activity(GO:0004743)
2.8 16.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
2.0 9.9 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.9 43.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
1.5 4.5 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.4 6.8 GO:0042296 ISG15 transferase activity(GO:0042296)
1.2 4.9 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
1.1 5.5 GO:0016936 galactoside binding(GO:0016936)
0.9 13.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.9 7.1 GO:0004111 creatine kinase activity(GO:0004111)
0.9 3.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.8 2.4 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.8 5.3 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.7 29.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.7 2.1 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.7 31.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.6 12.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.6 3.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.6 2.8 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.6 6.6 GO:0015266 protein channel activity(GO:0015266)
0.5 2.7 GO:1990460 leptin receptor binding(GO:1990460)
0.5 2.2 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.5 3.6 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.4 2.2 GO:1990254 keratin filament binding(GO:1990254)
0.4 24.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.4 3.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.4 3.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.4 4.4 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 3.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.3 9.2 GO:0070628 proteasome binding(GO:0070628)
0.3 6.5 GO:0005522 profilin binding(GO:0005522)
0.3 5.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.3 6.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 0.8 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.3 6.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 1.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.3 1.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.3 6.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 3.5 GO:0046790 virion binding(GO:0046790)
0.2 2.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 3.9 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 1.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 3.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 8.0 GO:0070840 dynein complex binding(GO:0070840)
0.2 8.9 GO:0000049 tRNA binding(GO:0000049)
0.2 1.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.2 1.0 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 2.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 9.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 8.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 8.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 3.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 10.0 GO:0005080 protein kinase C binding(GO:0005080)
0.2 1.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 2.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 5.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 9.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 2.9 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.6 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 5.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 1.4 GO:0050700 CARD domain binding(GO:0050700)
0.1 1.0 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 18.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 2.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 21.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.6 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 2.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 25.5 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 10.9 GO:0043130 ubiquitin binding(GO:0043130)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 4.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 3.2 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 4.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 2.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.2 GO:0003973 (S)-2-hydroxy-acid oxidase activity(GO:0003973) oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 3.0 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 1.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 1.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.5 GO:0015250 water channel activity(GO:0015250)
0.0 0.3 GO:0089720 caspase binding(GO:0089720)
0.0 0.8 GO:0005123 death receptor binding(GO:0005123)
0.0 1.8 GO:0005507 copper ion binding(GO:0005507)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.8 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 6.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 7.8 GO:0016887 ATPase activity(GO:0016887)
0.0 1.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 44.1 PID BARD1 PATHWAY BARD1 signaling events
0.6 14.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 11.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 13.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 8.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 7.4 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.2 10.6 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 13.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 22.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 8.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 2.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.6 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 2.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 2.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 4.2 PID BCR 5PATHWAY BCR signaling pathway
0.1 3.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 1.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 2.6 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 3.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 2.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID ATM PATHWAY ATM pathway
0.0 1.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 46.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.9 14.0 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.8 10.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.5 3.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.5 12.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 10.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.4 6.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.4 8.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 11.2 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 10.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3 6.5 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 9.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 3.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 20.6 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 3.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 3.5 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.2 4.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 3.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 4.9 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 11.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 3.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 22.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 6.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 12.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 2.9 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.1 1.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 3.1 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 1.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.6 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.1 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 2.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis