Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for HOXB5

Z-value: 1.68

Motif logo

logo of

Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.6 HOXB5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg38_v1_chr17_-_48593748_485937860.211.4e-03Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_48521817 11.73 ENST00000446158.5
ENST00000414061.1
EBP
EBP cholestenol delta-isomerase
chrX_+_48521788 7.71 ENST00000651615.1
ENST00000495186.6
ENSG00000286268.1
EBP
novel protein
EBP cholestenol delta-isomerase
chr19_-_49640092 6.22 ENST00000246792.4
RRAS
RAS related
chr14_-_102238439 5.40 ENST00000522534.5
MOK
MOK protein kinase
chr15_+_73926443 4.40 ENST00000261921.8
LOXL1
lysyl oxidase like 1
chr2_-_46941710 3.97 ENST00000409207.5
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr1_-_161223408 3.16 ENST00000491350.1
APOA2
apolipoprotein A2
chr1_-_161223559 3.15 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
APOA2
apolipoprotein A2
chr3_-_127822455 2.64 ENST00000265052.10
MGLL
monoglyceride lipase
chr3_+_51385282 2.29 ENST00000528157.7
MANF
mesencephalic astrocyte derived neurotrophic factor
chr2_-_46941760 2.27 ENST00000444761.6
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr19_-_15934410 2.14 ENST00000326742.12
CYP4F11
cytochrome P450 family 4 subfamily F member 11
chr8_-_132085655 2.11 ENST00000262283.5
ENSG00000258417.3
novel protein
chr12_+_53299682 2.09 ENST00000267103.10
ENST00000548632.5
MYG1
MYG1 exonuclease
chr1_-_16978276 2.01 ENST00000375534.7
MFAP2
microfibril associated protein 2
chr1_+_21981099 1.74 ENST00000400277.2
CELA3B
chymotrypsin like elastase 3B
chr7_+_130381092 1.69 ENST00000484324.1
CPA1
carboxypeptidase A1
chr1_+_154257071 1.68 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2 like
chr16_-_50368920 1.67 ENST00000394688.8
BRD7
bromodomain containing 7
chrX_+_47218232 1.64 ENST00000457458.6
ENST00000522883.1
CDK16
cyclin dependent kinase 16
chr16_-_84618067 1.53 ENST00000262428.5
COTL1
coactosin like F-actin binding protein 1
chr15_-_74725370 1.52 ENST00000567032.5
ENST00000564596.5
ENST00000566503.1
ENST00000395049.8
ENST00000379727.8
ENST00000617691.4
ENST00000395048.6
CYP1A1
cytochrome P450 family 1 subfamily A member 1
chr1_+_40691749 1.51 ENST00000372654.5
NFYC
nuclear transcription factor Y subunit gamma
chr20_-_49568101 1.49 ENST00000244043.5
PTGIS
prostaglandin I2 synthase
chr1_+_155610218 1.41 ENST00000649846.1
ENST00000245564.8
ENST00000368341.8
MSTO1
misato mitochondrial distribution and morphology regulator 1
chr1_+_40691998 1.38 ENST00000534399.5
ENST00000372653.5
NFYC
nuclear transcription factor Y subunit gamma
chr12_+_57591158 1.38 ENST00000422156.7
ENST00000354947.10
ENST00000540759.6
ENST00000551772.5
ENST00000550465.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr1_-_155688294 1.37 ENST00000311573.9
YY1AP1
YY1 associated protein 1
chr19_-_15934521 1.35 ENST00000402119.9
CYP4F11
cytochrome P450 family 4 subfamily F member 11
chr9_-_127937800 1.34 ENST00000373110.4
ENST00000314392.13
DPM2
dolichyl-phosphate mannosyltransferase subunit 2, regulatory
chr16_-_84618041 1.32 ENST00000564057.1
COTL1
coactosin like F-actin binding protein 1
chr17_-_44066595 1.20 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr16_-_1771495 1.12 ENST00000564628.1
ENST00000219302.8
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr17_+_48892761 1.11 ENST00000355938.9
ENST00000393366.7
ENST00000503641.5
ENST00000514808.5
ENST00000506855.1
ATP5MC1
ATP synthase membrane subunit c locus 1
chr1_+_235328959 1.09 ENST00000643758.1
ENST00000497327.1
TBCE
GGPS1
tubulin folding cofactor E
geranylgeranyl diphosphate synthase 1
chr12_+_56521798 0.97 ENST00000262031.10
RBMS2
RNA binding motif single stranded interacting protein 2
chr17_-_30906202 0.91 ENST00000580840.1
ENST00000581216.6
TEFM
transcription elongation factor, mitochondrial
chr1_-_155688475 0.90 ENST00000405763.7
ENST00000368340.9
ENST00000454523.5
ENST00000368339.9
ENST00000443231.5
ENST00000347088.9
ENST00000361831.9
YY1AP1
YY1 associated protein 1
chr20_+_8789517 0.85 ENST00000437439.2
PLCB1
phospholipase C beta 1
chr12_+_56521990 0.79 ENST00000550726.5
ENST00000542360.1
RBMS2
RNA binding motif single stranded interacting protein 2
chr6_-_31541937 0.77 ENST00000456662.5
ENST00000431908.5
ENST00000456976.5
ENST00000428450.5
ENST00000418897.5
ENST00000396172.6
ENST00000419020.1
ENST00000428098.5
DDX39B
DExD-box helicase 39B
chr12_+_56521951 0.75 ENST00000552247.6
RBMS2
RNA binding motif single stranded interacting protein 2
chr3_-_195811889 0.75 ENST00000475231.5
MUC4
mucin 4, cell surface associated
chr19_+_49363730 0.72 ENST00000596402.1
ENST00000221498.7
DKKL1
dickkopf like acrosomal protein 1
chr3_-_195811916 0.72 ENST00000463781.8
MUC4
mucin 4, cell surface associated
chr2_-_97589862 0.71 ENST00000258459.11
ENST00000438709.6
ANKRD36B
ankyrin repeat domain 36B
chr12_-_101407727 0.69 ENST00000539055.5
ENST00000551688.1
ENST00000551671.5
ENST00000261636.13
ARL1
ADP ribosylation factor like GTPase 1
chr1_+_40691689 0.66 ENST00000427410.6
ENST00000447388.7
ENST00000425457.6
ENST00000453631.5
ENST00000456393.6
NFYC
nuclear transcription factor Y subunit gamma
chr3_-_195811857 0.65 ENST00000349607.8
ENST00000346145.8
MUC4
mucin 4, cell surface associated
chr1_-_155688727 0.62 ENST00000404643.5
ENST00000359205.9
ENST00000407221.5
ENST00000355499.9
YY1AP1
YY1 associated protein 1
chr6_-_31542339 0.59 ENST00000458640.5
DDX39B
DExD-box helicase 39B
chr6_-_96837460 0.57 ENST00000229955.4
GPR63
G protein-coupled receptor 63
chr21_-_44262216 0.57 ENST00000270172.7
DNMT3L
DNA methyltransferase 3 like
chr2_-_187565751 0.57 ENST00000421427.5
TFPI
tissue factor pathway inhibitor
chr1_+_4654732 0.55 ENST00000378190.7
AJAP1
adherens junctions associated protein 1
chr19_-_49763295 0.53 ENST00000246801.8
TSKS
testis specific serine kinase substrate
chr1_+_235328399 0.50 ENST00000471812.5
ENST00000358966.6
ENST00000282841.9
ENST00000391855.2
ENST00000647428.1
ENST00000645655.1
ENST00000647186.1
ENST00000646624.1
ENST00000645205.1
ENST00000645351.1
GGPS1
TBCE
geranylgeranyl diphosphate synthase 1
tubulin folding cofactor E
chrX_-_107982370 0.49 ENST00000302917.1
TEX13B
testis expressed 13B
chr19_+_49363923 0.48 ENST00000597546.1
DKKL1
dickkopf like acrosomal protein 1
chr1_+_24502320 0.44 ENST00000538532.6
ENST00000618490.4
RCAN3
RCAN family member 3
chr1_+_116373233 0.36 ENST00000295598.10
ATP1A1
ATPase Na+/K+ transporting subunit alpha 1
chrM_+_12329 0.32 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chrX_+_14529516 0.30 ENST00000218075.9
GLRA2
glycine receptor alpha 2
chr10_-_101843765 0.28 ENST00000370046.5
KCNIP2
potassium voltage-gated channel interacting protein 2
chr8_-_92095598 0.28 ENST00000520724.5
ENST00000518844.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr1_+_161153968 0.27 ENST00000368003.6
UFC1
ubiquitin-fold modifier conjugating enzyme 1
chr14_+_21477177 0.26 ENST00000448790.7
ENST00000673643.1
ENST00000457430.2
ENST00000673911.1
TOX4
TOX high mobility group box family member 4
chr11_-_35419098 0.25 ENST00000606205.6
ENST00000645303.1
SLC1A2
solute carrier family 1 member 2
chr12_-_7665897 0.19 ENST00000229304.5
APOBEC1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
chr1_+_4654601 0.18 ENST00000378191.5
AJAP1
adherens junctions associated protein 1
chr6_+_29459771 0.18 ENST00000377132.1
OR2H1
olfactory receptor family 2 subfamily H member 1
chr1_+_157993601 0.17 ENST00000359209.11
KIRREL1
kirre like nephrin family adhesion molecule 1
chr11_-_128522189 0.15 ENST00000526145.6
ETS1
ETS proto-oncogene 1, transcription factor
chr19_-_13953302 0.09 ENST00000585607.1
ENST00000538517.6
ENST00000587458.1
ENST00000538371.6
PODNL1
podocan like 1
chr10_+_112376193 0.09 ENST00000433418.6
ENST00000356116.6
ENST00000354273.5
ACSL5
acyl-CoA synthetase long chain family member 5
chr7_+_121328991 0.09 ENST00000222462.3
WNT16
Wnt family member 16
chr17_-_7207245 0.08 ENST00000649971.1
DLG4
discs large MAGUK scaffold protein 4
chr16_+_31527876 0.07 ENST00000302312.9
ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr4_-_67754335 0.06 ENST00000420975.2
ENST00000226413.5
GNRHR
gonadotropin releasing hormone receptor
chr8_-_92095215 0.05 ENST00000360348.6
ENST00000520428.5
ENST00000518992.5
ENST00000520556.5
ENST00000518317.5
ENST00000521319.5
ENST00000521375.5
ENST00000518449.5
ENST00000613886.4
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chrX_+_136148440 0.03 ENST00000627383.2
ENST00000630084.2
FHL1
four and a half LIM domains 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 19.4 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
1.6 6.3 GO:0060620 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.9 3.5 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.5 1.6 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.5 1.5 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.3 2.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 2.0 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.3 0.8 GO:0007343 egg activation(GO:0007343)
0.3 1.3 GO:0019348 dolichol metabolic process(GO:0019348)
0.2 1.7 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 1.4 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 6.2 GO:0060325 face morphogenesis(GO:0060325)
0.1 1.4 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 1.5 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.7 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.1 6.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 2.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.9 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.7 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.1 2.9 GO:0050832 defense response to fungus(GO:0050832)
0.1 1.4 GO:0048311 mitochondrion distribution(GO:0048311)
0.1 0.6 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.6 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 4.4 GO:0035904 aorta development(GO:0035904)
0.1 2.3 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 1.1 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 1.6 GO:0030252 growth hormone secretion(GO:0030252)
0.0 3.6 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.4 GO:1903416 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032) response to glycoside(GO:1903416)
0.0 0.3 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 1.7 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:0070383 cytidine to uridine editing(GO:0016554) DNA cytosine deamination(GO:0070383) regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0 0.1 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.0 0.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 1.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.2 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 1.7 GO:0008203 cholesterol metabolic process(GO:0008203)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.4 6.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.3 3.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 2.9 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.7 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 5.4 GO:0097546 ciliary base(GO:0097546)
0.1 1.4 GO:0005688 U6 snRNP(GO:0005688)
0.1 2.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 6.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 4.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.7 GO:0090544 BAF-type complex(GO:0090544)
0.0 20.3 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.9 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.5 GO:0005901 caveola(GO:0005901)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.0 2.9 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 4.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 6.3 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.4 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
1.3 6.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.5 1.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.4 1.3 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.4 2.1 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.3 1.6 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.3 1.5 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.3 0.9 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.2 4.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.2 2.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 1.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 7.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 6.2 GO:0019003 GDP binding(GO:0019003)
0.1 3.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.3 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 1.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 3.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.8 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:1990239 sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239)
0.0 1.5 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 19.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 5.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.8 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 3.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.0 PID NOTCH PATHWAY Notch signaling pathway
0.0 5.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 21.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 6.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 6.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.1 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 6.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 6.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)