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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXB6_PRRX2

Z-value: 7.91

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Transcription factors associated with HOXB6_PRRX2

Gene Symbol Gene ID Gene Info
ENSG00000108511.10 HOXB6
ENSG00000167157.11 PRRX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRRX2hg38_v1_chr9_+_129665603_1296656720.523.0e-16Click!
HOXB6hg38_v1_chr17_-_48604959_48605000-0.082.5e-01Click!

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr12_-_16608073 181.25 ENST00000441439.6
LIM domain only 3
chr12_-_16608183 171.95 ENST00000354662.5
ENST00000538051.5
LIM domain only 3
chr4_-_175812746 154.44 ENST00000393658.6
glycoprotein M6A
chr2_-_2324323 136.23 ENST00000648339.1
ENST00000647694.1
myelin transcription factor 1 like
chr2_-_2324642 86.94 ENST00000650485.1
ENST00000649207.1
myelin transcription factor 1 like
chr2_-_174846405 84.97 ENST00000409597.5
ENST00000413882.6
chimerin 1
chr12_-_16606795 80.48 ENST00000447609.5
LIM domain only 3
chr5_-_88883701 73.54 ENST00000636998.1
myocyte enhancer factor 2C
chr16_+_7332839 73.07 ENST00000355637.9
RNA binding fox-1 homolog 1
chr16_+_7303245 71.50 ENST00000674626.1
RNA binding fox-1 homolog 1
chr16_+_7332744 71.15 ENST00000436368.6
ENST00000311745.9
ENST00000340209.8
ENST00000620507.4
RNA binding fox-1 homolog 1
chr2_-_49974155 68.95 ENST00000635519.1
neurexin 1
chr18_-_55422492 66.25 ENST00000561992.5
ENST00000630712.2
transcription factor 4
chr2_-_49974182 65.00 ENST00000412315.5
ENST00000378262.7
neurexin 1
chr12_-_16606102 63.29 ENST00000537304.6
LIM domain only 3
chr1_+_50103903 62.66 ENST00000371827.5
ELAV like RNA binding protein 4
chr12_-_16605939 61.94 ENST00000541295.5
ENST00000535535.5
LIM domain only 3
chr1_+_50108856 57.40 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAV like RNA binding protein 4
chr4_+_157220691 55.64 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
glutamate ionotropic receptor AMPA type subunit 2
chr8_+_79611036 54.63 ENST00000220876.12
ENST00000518111.5
stathmin 2
chr8_-_18887018 49.66 ENST00000523619.5
pleckstrin and Sec7 domain containing 3
chr7_-_31340678 48.24 ENST00000297142.4
neuronal differentiation 6
chr13_-_35855627 46.58 ENST00000379893.5
doublecortin like kinase 1
chr2_-_223602284 43.14 ENST00000421386.1
ENST00000305409.3
ENST00000433889.1
secretogranin II
chr18_-_55351977 42.93 ENST00000643689.1
transcription factor 4
chr3_+_159069252 42.12 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1 readthrough
chr3_+_111998915 41.20 ENST00000478951.6
transgelin 3
chr12_+_78864768 40.27 ENST00000261205.9
ENST00000457153.6
synaptotagmin 1
chr18_-_55322215 40.06 ENST00000457482.7
transcription factor 4
chr2_-_49974083 40.05 ENST00000636345.1
neurexin 1
chr13_-_35855758 39.92 ENST00000615680.4
doublecortin like kinase 1
chr3_+_111999189 39.86 ENST00000455401.6
transgelin 3
chr12_-_91182652 39.73 ENST00000552145.5
ENST00000546745.5
decorin
chr3_+_111998739 39.69 ENST00000393917.6
ENST00000273368.8
transgelin 3
chr4_+_157220654 39.37 ENST00000393815.6
glutamate ionotropic receptor AMPA type subunit 2
chrX_-_13817346 38.90 ENST00000356942.9
glycoprotein M6B
chr5_+_36606355 37.49 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
solute carrier family 1 member 3
chr3_+_111999326 37.32 ENST00000494932.1
transgelin 3
chr18_-_55321986 37.24 ENST00000570287.6
transcription factor 4
chr12_-_91182784 36.16 ENST00000547568.6
ENST00000052754.10
ENST00000552962.5
decorin
chr6_-_6006878 35.28 ENST00000244766.7
neuritin 1
chr8_+_84705920 34.92 ENST00000523850.5
ENST00000521376.1
RALY RNA binding protein like
chr18_-_55422306 34.60 ENST00000566777.5
ENST00000626584.2
transcription factor 4
chr6_-_6007511 34.51 ENST00000616243.1
neuritin 1
chr6_-_46325641 34.16 ENST00000330430.10
ENST00000405162.2
regulator of calcineurin 2
chr3_+_35679614 33.69 ENST00000474696.5
ENST00000412048.5
ENST00000396482.6
ENST00000432682.5
cAMP regulated phosphoprotein 21
chr1_+_204870831 33.20 ENST00000404076.5
ENST00000539706.6
neurofascin
chr3_+_159839847 32.96 ENST00000445224.6
schwannomin interacting protein 1
chr5_-_88883420 32.83 ENST00000437473.6
myocyte enhancer factor 2C
chr5_+_67004618 32.67 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr16_+_7510102 32.62 ENST00000682918.1
ENST00000683326.1
ENST00000570626.2
RNA binding fox-1 homolog 1
chr5_-_24644968 31.92 ENST00000264463.8
cadherin 10
chr1_+_65264694 31.87 ENST00000263441.11
ENST00000395325.7
DnaJ heat shock protein family (Hsp40) member C6
chr18_-_55587335 31.81 ENST00000638154.3
transcription factor 4
chrX_-_13817027 31.39 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr2_+_183078736 31.22 ENST00000354221.5
dual specificity phosphatase 19
chr13_-_44436801 30.33 ENST00000261489.6
TSC22 domain family member 1
chr8_-_119638780 30.09 ENST00000522826.5
ENST00000520066.5
ENST00000259486.10
ENST00000075322.11
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr3_-_114758940 30.01 ENST00000464560.5
zinc finger and BTB domain containing 20
chr2_-_49973939 29.13 ENST00000630656.1
neurexin 1
chr8_-_101790934 29.00 ENST00000523645.5
ENST00000520346.1
ENST00000220931.11
ENST00000522448.5
ENST00000522951.5
ENST00000522252.5
ENST00000519098.5
neurocalcin delta
chr12_+_78863962 28.80 ENST00000393240.7
synaptotagmin 1
chr4_+_41256921 28.60 ENST00000284440.9
ENST00000508768.5
ENST00000512788.1
ubiquitin C-terminal hydrolase L1
chr11_-_31804067 28.23 ENST00000639548.1
ENST00000640125.1
ENST00000481563.6
ENST00000639079.1
ENST00000638762.1
ENST00000638346.1
paired box 6
chr3_-_114759115 28.03 ENST00000471418.5
zinc finger and BTB domain containing 20
chr2_-_2331336 27.76 ENST00000648933.1
ENST00000644820.1
myelin transcription factor 1 like
chr2_+_200440649 27.70 ENST00000366118.2
spermatogenesis associated serine rich 2 like
chr11_+_131370478 26.80 ENST00000374791.7
ENST00000683400.1
ENST00000436745.5
neurotrimin
chr2_+_172860038 26.72 ENST00000538974.5
ENST00000540783.5
Rap guanine nucleotide exchange factor 4
chr2_-_174847015 26.49 ENST00000650938.1
chimerin 1
chr15_+_92900189 25.90 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
chromodomain helicase DNA binding protein 2
chr14_+_28766755 25.59 ENST00000313071.7
forkhead box G1
chr2_+_161416273 25.57 ENST00000389554.8
T-box brain transcription factor 1
chr4_-_152352800 25.44 ENST00000393956.9
F-box and WD repeat domain containing 7
chr18_-_55510753 25.09 ENST00000543082.5
transcription factor 4
chr2_-_2331225 24.93 ENST00000648627.1
ENST00000649663.1
ENST00000650560.1
ENST00000428368.7
ENST00000648316.1
ENST00000648665.1
ENST00000649313.1
ENST00000399161.7
ENST00000647738.2
myelin transcription factor 1 like
chrX_+_136196750 24.82 ENST00000539015.5
four and a half LIM domains 1
chr11_-_111923722 24.81 ENST00000527950.5
crystallin alpha B
chr11_-_129192291 24.56 ENST00000682385.1
Rho GTPase activating protein 32
chr18_-_24311495 24.56 ENST00000357041.8
oxysterol binding protein like 1A
chr4_+_113116676 24.50 ENST00000671971.1
ENST00000672240.1
ENST00000673240.1
ENST00000673363.1
ankyrin 2
chr13_+_35476740 24.29 ENST00000537702.5
neurobeachin
chr7_-_126533850 24.21 ENST00000444921.3
glutamate metabotropic receptor 8
chr7_-_27140195 24.14 ENST00000522788.5
ENST00000317201.7
homeobox A3
chr1_+_151060357 24.04 ENST00000368921.5
MLLT11 transcription factor 7 cofactor
chr17_-_55511434 23.95 ENST00000636752.1
small integral membrane protein 36
chr20_+_10218808 23.92 ENST00000254976.7
ENST00000304886.6
synaptosome associated protein 25
chr18_-_55423757 23.66 ENST00000675707.1
transcription factor 4
chr16_-_29899532 23.60 ENST00000308713.9
ENST00000617533.5
seizure related 6 homolog like 2
chr1_-_56579555 23.60 ENST00000371250.4
phospholipid phosphatase 3
chrX_+_136197039 23.27 ENST00000370683.6
four and a half LIM domains 1
chr2_-_174847525 23.14 ENST00000295497.12
ENST00000652036.1
ENST00000444394.6
ENST00000650731.1
chimerin 1
chr16_+_8712943 22.84 ENST00000561870.5
ENST00000396600.6
4-aminobutyrate aminotransferase
chr1_+_92168915 22.79 ENST00000637221.2
BTB domain containing 8
chr4_+_113049479 22.62 ENST00000671727.1
ENST00000671762.1
ENST00000672366.1
ENST00000672502.1
ENST00000672045.1
ENST00000672251.1
ENST00000672854.1
ankyrin 2
chrX_+_136197020 22.56 ENST00000370676.7
four and a half LIM domains 1
chr14_+_22508602 22.49 ENST00000390504.1
T cell receptor alpha joining 33
chr18_-_55403682 22.37 ENST00000564228.5
ENST00000630828.2
transcription factor 4
chr1_+_84164370 22.23 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
protein kinase cAMP-activated catalytic subunit beta
chr12_+_79045625 22.02 ENST00000552744.5
synaptotagmin 1
chr11_-_111911759 22.01 ENST00000650687.2
crystallin alpha B
chr2_-_60553409 21.71 ENST00000358510.6
ENST00000643004.1
BAF chromatin remodeling complex subunit BCL11A
chr2_+_148978361 21.45 ENST00000678720.1
ENST00000678856.1
ENST00000677080.1
kinesin family member 5C
chr11_-_129192198 21.44 ENST00000310343.13
Rho GTPase activating protein 32
chr5_+_72107453 21.06 ENST00000296755.12
ENST00000511641.2
microtubule associated protein 1B
chr2_-_144517663 20.96 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
zinc finger E-box binding homeobox 2
chr2_-_2326378 20.91 ENST00000647618.1
myelin transcription factor 1 like
chr4_+_113292838 20.74 ENST00000672411.1
ENST00000673231.1
ankyrin 2
chr2_+_165572329 20.43 ENST00000342316.8
cysteine and serine rich nuclear protein 3
chr3_-_58627567 20.33 ENST00000649301.1
family with sequence similarity 107 member A
chr11_-_31803960 19.74 ENST00000640872.1
ENST00000639109.1
ENST00000638629.1
ENST00000639386.2
paired box 6
chr4_+_113292925 19.63 ENST00000673353.1
ENST00000505342.6
ENST00000672915.1
ENST00000509550.5
ankyrin 2
chr6_+_12957301 19.15 ENST00000676234.1
phosphatase and actin regulator 1
chr14_-_100569780 18.83 ENST00000355173.7
brain enriched guanylate kinase associated
chr18_-_55589795 18.81 ENST00000568740.5
ENST00000629387.2
transcription factor 4
chr18_-_55402187 18.77 ENST00000630268.2
ENST00000570177.6
transcription factor 4
chr3_+_35680994 18.73 ENST00000441454.5
cAMP regulated phosphoprotein 21
chr4_+_113049616 18.27 ENST00000504454.5
ENST00000357077.9
ENST00000394537.7
ENST00000672779.1
ENST00000264366.10
ankyrin 2
chr5_+_171309239 18.22 ENST00000296921.6
T cell leukemia homeobox 3
chr16_+_6483379 18.18 ENST00000552089.5
RNA binding fox-1 homolog 1
chr7_-_27143672 18.17 ENST00000222726.4
homeobox A5
chr8_-_18684093 18.13 ENST00000428502.6
pleckstrin and Sec7 domain containing 3
chr2_+_209579598 17.88 ENST00000445941.5
ENST00000673860.1
microtubule associated protein 2
chr2_+_209579399 17.83 ENST00000360351.8
microtubule associated protein 2
chr10_-_60389833 17.81 ENST00000280772.7
ankyrin 3
chr9_+_100442271 17.78 ENST00000502978.1
MSANTD3-TMEFF1 readthrough
chr12_-_91180365 17.74 ENST00000547937.5
decorin
chr18_-_55589836 17.74 ENST00000537578.5
ENST00000564403.6
transcription factor 4
chr11_+_123525822 17.69 ENST00000322282.11
ENST00000529750.5
GRAM domain containing 1B
chr2_+_209580024 17.47 ENST00000392194.5
microtubule associated protein 2
chrX_+_136169624 17.45 ENST00000394153.6
four and a half LIM domains 1
chr2_+_165294031 17.43 ENST00000283256.10
sodium voltage-gated channel alpha subunit 2
chr5_+_68290637 17.39 ENST00000336483.9
phosphoinositide-3-kinase regulatory subunit 1
chr5_+_161850597 17.33 ENST00000634335.1
ENST00000635880.1
gamma-aminobutyric acid type A receptor subunit alpha1
chr18_-_55321640 17.31 ENST00000637169.2
transcription factor 4
chr17_+_43211835 17.21 ENST00000588693.5
ENST00000588659.5
ENST00000541594.5
ENST00000536052.5
ENST00000612339.4
transmembrane protein 106A
chr4_-_185956652 17.12 ENST00000355634.9
sorbin and SH3 domain containing 2
chr5_+_162067458 17.07 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
gamma-aminobutyric acid type A receptor subunit gamma2
chr1_+_50106265 16.92 ENST00000357083.8
ELAV like RNA binding protein 4
chr6_-_169253835 16.84 ENST00000649844.1
ENST00000617924.6
thrombospondin 2
chr12_+_80716906 16.65 ENST00000228644.4
myogenic factor 5
chr22_-_35840577 16.60 ENST00000405409.6
RNA binding fox-1 homolog 2
chr18_-_55589770 16.56 ENST00000565018.6
ENST00000636400.2
transcription factor 4
chr1_+_155859550 16.51 ENST00000368324.5
synaptotagmin 11
chr11_-_117877463 16.50 ENST00000527717.5
FXYD domain containing ion transport regulator 6
chr4_+_87975667 16.35 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
secreted phosphoprotein 1
chr15_+_74130551 16.33 ENST00000453268.3
immunoglobulin superfamily containing leucine rich repeat 2
chr2_+_66435558 16.29 ENST00000488550.5
Meis homeobox 1
chr6_+_45328203 16.28 ENST00000371432.7
ENST00000647337.2
ENST00000371438.5
RUNX family transcription factor 2
chr11_-_117876892 16.27 ENST00000539526.5
FXYD domain containing ion transport regulator 6
chr12_-_91146195 16.24 ENST00000548218.1
decorin
chr12_-_51217671 16.15 ENST00000333640.11
ENST00000550824.6
POU class 6 homeobox 1
chr11_-_123654939 16.13 ENST00000657191.1
sodium voltage-gated channel beta subunit 3
chr9_-_14300231 16.07 ENST00000636735.1
nuclear factor I B
chr2_-_212538841 15.99 ENST00000436443.5
erb-b2 receptor tyrosine kinase 4
chr1_+_162632454 15.97 ENST00000367921.8
ENST00000367922.7
discoidin domain receptor tyrosine kinase 2
chr2_-_151973780 15.95 ENST00000637514.1
ENST00000636350.1
ENST00000434468.2
ENST00000637762.1
ENST00000637779.1
ENST00000637547.1
ENST00000636901.1
ENST00000397327.7
ENST00000636721.1
ENST00000636380.1
ENST00000637284.1
ENST00000636617.1
ENST00000636947.1
ENST00000638091.1
ENST00000636108.1
ENST00000638040.1
ENST00000636773.1
ENST00000637418.1
ENST00000637216.1
calcium voltage-gated channel auxiliary subunit beta 4
chr12_+_101666203 15.74 ENST00000549608.1
myosin binding protein C1
chr4_+_112818088 15.62 ENST00000673044.1
ENST00000672696.1
ENST00000672315.1
ENST00000672088.1
ENST00000671793.1
ENST00000672402.1
ENST00000671825.1
ENST00000672312.1
ENST00000672830.1
ENST00000672731.1
ENST00000671854.1
ENST00000672350.1
ENST00000672684.1
ENST00000672934.1
ENST00000673546.1
ENST00000673573.1
ENST00000503423.6
ENST00000673255.1
ENST00000671893.1
ENST00000672246.1
ENST00000672930.1
ENST00000673334.1
ENST00000673453.1
ENST00000673555.1
ENST00000672880.1
ENST00000672990.1
ENST00000673430.1
ENST00000673298.1
ENST00000672068.1
ENST00000672362.1
ENST00000672793.1
ENST00000672209.1
ENST00000671756.1
ENST00000671809.1
ENST00000671906.1
ENST00000672090.1
ENST00000672177.1
ENST00000672759.1
ENST00000672965.1
ENST00000673109.1
ENST00000503271.5
ENST00000506722.5
ENST00000673536.1
ENST00000672986.1
ankyrin 2
chr12_+_54053815 15.54 ENST00000430889.3
homeobox C4
chr9_-_14307928 15.49 ENST00000637640.1
ENST00000493697.1
ENST00000636057.1
nuclear factor I B
chr6_-_56851888 15.43 ENST00000312431.10
ENST00000520645.5
dystonin
chr11_-_84923162 15.42 ENST00000524982.5
discs large MAGUK scaffold protein 2
chr14_-_68794597 15.32 ENST00000336440.3
ZFP36 ring finger protein like 1
chr5_-_161546671 15.32 ENST00000517547.5
gamma-aminobutyric acid type A receptor subunit beta2
chr4_+_112818032 15.21 ENST00000672356.1
ENST00000672955.1
ankyrin 2
chr5_+_162067500 15.18 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
gamma-aminobutyric acid type A receptor subunit gamma2
chr8_+_103880412 15.12 ENST00000436393.6
regulating synaptic membrane exocytosis 2
chr4_+_41612892 15.12 ENST00000509454.5
ENST00000396595.7
ENST00000381753.8
LIM and calponin homology domains 1
chr4_+_87975829 14.87 ENST00000614857.5
secreted phosphoprotein 1
chr2_+_209579429 14.83 ENST00000361559.8
microtubule associated protein 2
chr5_+_141430499 14.82 ENST00000252085.4
protocadherin gamma subfamily A, 12
chr16_-_29899245 14.71 ENST00000537485.5
seizure related 6 homolog like 2
chr3_-_114624193 14.69 ENST00000481632.5
zinc finger and BTB domain containing 20
chr5_+_161848112 14.67 ENST00000393943.10
gamma-aminobutyric acid type A receptor subunit alpha1
chr5_-_88883147 14.66 ENST00000513252.5
ENST00000506554.5
ENST00000508569.5
ENST00000637732.1
ENST00000504921.7
ENST00000637481.1
ENST00000510942.5
myocyte enhancer factor 2C
chr4_-_185956348 14.59 ENST00000431902.5
ENST00000284776.11
ENST00000415274.5
sorbin and SH3 domain containing 2
chr3_+_129528632 14.54 ENST00000296271.4
rhodopsin
chr2_-_2326210 14.29 ENST00000647755.1
myelin transcription factor 1 like
chr7_-_42152444 14.22 ENST00000479210.1
GLI family zinc finger 3
chr13_+_95433593 14.18 ENST00000376873.7
claudin 10
chr3_-_127822455 14.09 ENST00000265052.10
monoglyceride lipase
chr4_+_71339014 14.09 ENST00000340595.4
solute carrier family 4 member 4
chr12_-_9115907 14.05 ENST00000318602.12
alpha-2-macroglobulin
chrX_+_49879475 14.04 ENST00000621775.2
ubiquitin specific peptidase 27 X-linked
chr12_-_49897056 13.93 ENST00000552863.5
Fas apoptotic inhibitory molecule 2
chr8_-_27258414 13.89 ENST00000523048.5
stathmin 4
chr4_+_87832917 13.83 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr1_+_76867469 13.81 ENST00000477717.6
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr7_+_90709816 13.75 ENST00000436577.3
cyclin dependent kinase 14
chr18_-_55635948 13.72 ENST00000565124.4
ENST00000398339.5
transcription factor 4
chr5_-_11589019 13.69 ENST00000511377.5
catenin delta 2
chr15_+_33968484 13.67 ENST00000383263.7
cholinergic receptor muscarinic 5
chr18_-_55585773 13.54 ENST00000563824.5
ENST00000626425.2
ENST00000566514.5
ENST00000568673.5
ENST00000562847.5
ENST00000568147.5
transcription factor 4
chr2_+_54558348 13.44 ENST00000333896.5
spectrin beta, non-erythrocytic 1
chr5_-_138875290 13.26 ENST00000521094.2
ENST00000274711.7
leucine rich repeat transmembrane neuronal 2
chr16_-_21278282 13.21 ENST00000572914.2
crystallin mu
chr3_+_115623502 13.19 ENST00000305124.11
ENST00000393780.3
growth associated protein 43
chr7_-_42152396 13.18 ENST00000642432.1
ENST00000647255.1
ENST00000677288.1
GLI family zinc finger 3
chrX_+_136169891 13.14 ENST00000449474.5
four and a half LIM domains 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
79.8 558.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
30.4 91.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
19.1 210.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
16.8 134.6 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
13.7 136.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
13.7 54.6 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
10.4 31.2 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
10.0 129.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
9.1 27.4 GO:0060873 subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875)
8.6 34.4 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
8.6 34.3 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
8.5 25.4 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
8.3 8.3 GO:0021779 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
8.2 32.7 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
7.9 282.9 GO:0048665 neuron fate specification(GO:0048665)
7.1 28.5 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
6.6 33.1 GO:0021764 amygdala development(GO:0021764)
6.5 13.1 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
6.3 107.7 GO:0003322 pancreatic A cell development(GO:0003322)
6.2 74.1 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
6.0 60.3 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
6.0 161.0 GO:0071420 cellular response to histamine(GO:0071420)
5.7 28.6 GO:0007412 axon target recognition(GO:0007412)
5.7 34.0 GO:0097338 response to clozapine(GO:0097338)
5.7 45.3 GO:0021767 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
5.5 16.5 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422) negative regulation of membrane invagination(GO:1905154)
5.3 26.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
5.1 15.3 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
5.1 40.6 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
4.9 14.6 GO:0060435 bronchiole development(GO:0060435)
4.7 4.7 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
4.7 14.1 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
4.4 8.8 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
4.1 45.3 GO:2000795 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
4.1 40.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
4.0 27.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
3.9 3.9 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
3.9 143.6 GO:0008045 motor neuron axon guidance(GO:0008045)
3.8 45.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
3.7 18.5 GO:0016198 axon choice point recognition(GO:0016198)
3.7 29.5 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
3.4 85.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
3.4 95.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
3.3 13.1 GO:0099558 maintenance of synapse structure(GO:0099558)
3.3 32.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
3.2 6.5 GO:0051866 general adaptation syndrome(GO:0051866)
3.1 129.7 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
3.1 9.2 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
3.0 9.0 GO:0036292 DNA rewinding(GO:0036292)
2.8 5.6 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
2.8 46.8 GO:0007021 tubulin complex assembly(GO:0007021)
2.7 2.7 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
2.7 19.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
2.7 29.7 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
2.7 8.0 GO:0060018 astrocyte fate commitment(GO:0060018)
2.7 31.9 GO:0016191 synaptic vesicle uncoating(GO:0016191)
2.6 21.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
2.6 193.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
2.6 12.8 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
2.5 47.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
2.4 31.7 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
2.4 155.5 GO:0003254 regulation of membrane depolarization(GO:0003254)
2.4 12.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
2.4 2.4 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
2.3 11.7 GO:0061032 cardiac right ventricle formation(GO:0003219) visceral serous pericardium development(GO:0061032)
2.3 105.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.3 16.3 GO:0002051 osteoblast fate commitment(GO:0002051)
2.3 21.0 GO:0008354 germ cell migration(GO:0008354)
2.3 30.1 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
2.3 20.8 GO:0008090 retrograde axonal transport(GO:0008090)
2.3 9.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
2.3 59.7 GO:0021542 dentate gyrus development(GO:0021542)
2.3 2.3 GO:0042640 anagen(GO:0042640)
2.2 11.2 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
2.2 8.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
2.2 8.6 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
2.1 6.4 GO:0060364 frontal suture morphogenesis(GO:0060364)
2.1 10.3 GO:0060385 axonogenesis involved in innervation(GO:0060385)
2.0 12.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
2.0 19.9 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
2.0 7.9 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
1.9 3.9 GO:1902285 sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285)
1.9 19.3 GO:0021681 cerebellar granular layer development(GO:0021681)
1.9 30.8 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
1.9 21.2 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
1.9 1.9 GO:1902232 regulation of positive thymic T cell selection(GO:1902232)
1.9 93.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.9 5.7 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
1.9 32.0 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
1.8 5.5 GO:1990418 response to insulin-like growth factor stimulus(GO:1990418)
1.8 7.3 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.8 5.5 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.8 3.6 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
1.8 3.6 GO:1900145 regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900175)
1.8 7.2 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
1.8 7.0 GO:0048318 axial mesoderm development(GO:0048318)
1.8 12.3 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
1.8 10.6 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.7 5.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
1.7 6.7 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
1.7 21.8 GO:0007258 JUN phosphorylation(GO:0007258)
1.7 3.3 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
1.7 6.7 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
1.7 10.0 GO:1990034 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
1.7 8.3 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
1.6 6.5 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
1.6 6.5 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
1.6 21.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
1.6 4.8 GO:0072674 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
1.6 27.0 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
1.6 3.2 GO:0007356 thorax and anterior abdomen determination(GO:0007356)
1.6 14.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.6 18.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
1.5 6.2 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
1.5 3.1 GO:0030035 microspike assembly(GO:0030035)
1.5 4.6 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
1.5 4.6 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
1.5 6.0 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.5 1.5 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
1.4 5.8 GO:0021800 cerebral cortex tangential migration(GO:0021800)
1.4 27.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
1.4 12.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
1.4 11.0 GO:0061709 reticulophagy(GO:0061709)
1.4 26.1 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
1.4 378.0 GO:0065004 protein-DNA complex assembly(GO:0065004)
1.3 8.1 GO:0006543 glutamine catabolic process(GO:0006543)
1.3 4.0 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
1.3 2.6 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
1.3 92.8 GO:0006501 C-terminal protein lipidation(GO:0006501)
1.3 7.7 GO:0060594 mammary gland specification(GO:0060594)
1.3 2.5 GO:0061113 pancreas morphogenesis(GO:0061113)
1.3 16.6 GO:0006554 lysine catabolic process(GO:0006554)
1.3 6.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.2 3.7 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
1.2 3.7 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
1.2 5.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.2 2.5 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
1.2 8.5 GO:0018095 protein polyglutamylation(GO:0018095)
1.2 2.4 GO:0021571 rhombomere 5 development(GO:0021571)
1.2 2.4 GO:0097325 melanocyte proliferation(GO:0097325)
1.2 3.5 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
1.2 4.7 GO:0042441 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
1.2 16.2 GO:0061162 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
1.2 37.1 GO:0007019 microtubule depolymerization(GO:0007019)
1.1 4.6 GO:0060023 soft palate development(GO:0060023)
1.1 8.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
1.1 56.8 GO:0021954 central nervous system neuron development(GO:0021954)
1.1 5.7 GO:0016926 protein desumoylation(GO:0016926)
1.1 4.5 GO:0046485 ether lipid metabolic process(GO:0046485)
1.1 9.0 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
1.1 12.8 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
1.1 5.3 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
1.0 4.2 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.0 4.2 GO:0036269 swimming behavior(GO:0036269)
1.0 87.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.0 3.1 GO:0097272 ammonia homeostasis(GO:0097272)
1.0 11.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
1.0 7.1 GO:0015811 L-cystine transport(GO:0015811)
1.0 7.0 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
1.0 7.0 GO:0070166 enamel mineralization(GO:0070166)
1.0 6.0 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.0 22.1 GO:0015874 norepinephrine transport(GO:0015874)
1.0 58.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
1.0 1.9 GO:0086053 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
1.0 3.8 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
1.0 5.7 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
1.0 5.7 GO:0071105 response to interleukin-11(GO:0071105)
1.0 2.9 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.9 6.5 GO:0036343 psychomotor behavior(GO:0036343) motor behavior(GO:0061744)
0.9 4.6 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.9 4.6 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.9 143.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9 2.7 GO:0061743 motor learning(GO:0061743)
0.9 21.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.9 4.5 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.9 3.6 GO:0001519 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.9 37.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.9 7.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.9 31.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.9 0.9 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.9 4.4 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.9 13.8 GO:0018298 protein-chromophore linkage(GO:0018298)
0.8 7.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.8 4.1 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.8 7.4 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263)
0.8 4.9 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.8 12.2 GO:0007638 mechanosensory behavior(GO:0007638)
0.8 3.3 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.8 6.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.8 24.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.8 9.4 GO:0034465 response to carbon monoxide(GO:0034465)
0.8 3.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.8 6.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.8 16.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.8 6.8 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.8 6.0 GO:0015824 proline transport(GO:0015824)
0.8 2.3 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.7 1.5 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.7 6.0 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.7 9.6 GO:0035878 nail development(GO:0035878)
0.7 39.8 GO:0015701 bicarbonate transport(GO:0015701)
0.7 2.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.7 1.5 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.7 2.2 GO:0002326 B cell lineage commitment(GO:0002326)
0.7 3.6 GO:0010748 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.7 4.9 GO:0060013 righting reflex(GO:0060013)
0.7 25.2 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.7 4.1 GO:0050955 thermoception(GO:0050955)
0.7 6.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.7 26.1 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.6 3.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.6 3.1 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.6 3.0 GO:0014807 regulation of somitogenesis(GO:0014807)
0.6 3.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.6 16.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.6 3.5 GO:0021781 glial cell fate commitment(GO:0021781)
0.6 0.6 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.6 5.3 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.6 2.9 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.6 4.6 GO:0070995 NADPH oxidation(GO:0070995)
0.6 10.9 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.6 2.3 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.6 2.8 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.6 25.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.6 6.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.5 6.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.5 1.6 GO:0043416 positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416)
0.5 2.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.5 3.2 GO:0035865 cellular response to potassium ion(GO:0035865)
0.5 5.3 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.5 6.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.5 2.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.5 16.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.5 8.2 GO:0016048 detection of temperature stimulus(GO:0016048) sensory perception of temperature stimulus(GO:0050951)
0.5 2.0 GO:0018343 protein farnesylation(GO:0018343)
0.5 8.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.5 10.0 GO:0014047 glutamate secretion(GO:0014047)
0.5 15.5 GO:0042572 retinol metabolic process(GO:0042572)
0.5 16.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.4 6.3 GO:0006527 arginine catabolic process(GO:0006527)
0.4 7.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.4 4.4 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.4 31.9 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.4 3.9 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.4 8.5 GO:0071625 vocalization behavior(GO:0071625)
0.4 3.4 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.4 2.9 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.4 5.8 GO:0097152 mesenchymal cell apoptotic process(GO:0097152)
0.4 2.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.4 3.6 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.4 3.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 5.2 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.4 5.5 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.4 4.7 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 18.5 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.4 27.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.4 4.2 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.4 2.8 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.4 4.2 GO:0071285 cellular response to lithium ion(GO:0071285)
0.4 2.1 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.4 1.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.3 65.4 GO:0007411 axon guidance(GO:0007411)
0.3 1.7 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.3 1.7 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.3 3.4 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.3 15.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.3 4.5 GO:0006020 inositol metabolic process(GO:0006020)
0.3 1.0 GO:0016999 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.3 1.6 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.3 1.5 GO:0030070 insulin processing(GO:0030070)
0.3 1.5 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.3 2.4 GO:0015747 urate transport(GO:0015747)
0.3 7.2 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.3 2.4 GO:0006069 ethanol oxidation(GO:0006069)
0.3 1.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.3 5.1 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.3 4.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.3 3.8 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.3 7.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 30.9 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 5.7 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.2 13.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 3.6 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.7 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.2 5.4 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.2 1.5 GO:0001865 NK T cell differentiation(GO:0001865)
0.2 1.7 GO:0042908 xenobiotic transport(GO:0042908)
0.2 3.8 GO:0021591 ventricular system development(GO:0021591)
0.2 0.4 GO:0070459 prolactin secretion(GO:0070459)
0.2 1.3 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.2 8.4 GO:1901998 toxin transport(GO:1901998)
0.2 1.2 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.2 12.3 GO:0032508 DNA duplex unwinding(GO:0032508)
0.2 2.3 GO:1903859 regulation of dendrite extension(GO:1903859)
0.2 2.7 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 3.0 GO:0006198 cAMP catabolic process(GO:0006198)
0.2 0.9 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 0.5 GO:0060197 cloacal septation(GO:0060197)
0.2 4.7 GO:0060612 adipose tissue development(GO:0060612)
0.2 2.7 GO:0005513 detection of calcium ion(GO:0005513)
0.2 1.9 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.2 1.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 0.6 GO:0001692 histamine metabolic process(GO:0001692)
0.2 0.9 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 2.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 9.7 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 2.1 GO:0090278 negative regulation of insulin secretion(GO:0046676) negative regulation of peptide hormone secretion(GO:0090278)
0.1 1.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 5.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.1 1.1 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.1 3.2 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.7 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.1 2.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 1.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 2.2 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 12.1 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 2.7 GO:0010761 fibroblast migration(GO:0010761)
0.1 0.8 GO:0070141 response to UV-A(GO:0070141) cellular response to UV-A(GO:0071492)
0.1 0.3 GO:2000342 ERK5 cascade(GO:0070375) negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1 2.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 1.3 GO:0032232 negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497)
0.1 3.5 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 0.3 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 8.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 3.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.7 GO:0034378 chylomicron assembly(GO:0034378)
0.1 0.5 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.1 0.5 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 1.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 2.0 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.1 1.6 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 3.0 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.1 1.8 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 4.6 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 0.5 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 0.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.8 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.1 1.3 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 1.9 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.4 GO:0045655 regulation of monocyte differentiation(GO:0045655)
0.0 1.0 GO:0048536 spleen development(GO:0048536)
0.0 0.6 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.2 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.3 GO:0007379 segment specification(GO:0007379)
0.0 1.7 GO:0042073 intraciliary transport(GO:0042073)
0.0 1.6 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 2.8 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 6.2 GO:0009408 response to heat(GO:0009408)
0.0 1.1 GO:0002548 monocyte chemotaxis(GO:0002548)
0.0 1.1 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.9 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.1 GO:0070409 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) cellular response to oleic acid(GO:0071400) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.0 0.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.1 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 3.3 GO:0007568 aging(GO:0007568)
0.0 0.8 GO:0009060 aerobic respiration(GO:0009060)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
31.7 95.0 GO:0098843 postsynaptic endocytic zone(GO:0098843)
18.2 91.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
9.7 126.6 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
9.0 72.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
8.0 31.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
6.6 33.2 GO:0097454 Schwann cell microvillus(GO:0097454)
6.5 26.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
6.2 154.1 GO:0044295 axonal growth cone(GO:0044295)
6.0 23.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
5.7 22.8 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
4.7 18.8 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
4.7 32.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
4.4 177.5 GO:1902711 GABA-A receptor complex(GO:1902711)
4.2 20.8 GO:0031673 H zone(GO:0031673)
4.1 102.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
3.5 205.3 GO:0031430 M band(GO:0031430)
3.5 41.7 GO:0016013 syntrophin complex(GO:0016013)
3.3 16.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
2.6 13.2 GO:0032584 growth cone membrane(GO:0032584)
2.5 299.1 GO:0042734 presynaptic membrane(GO:0042734)
2.4 43.1 GO:0031045 dense core granule(GO:0031045)
2.3 72.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
2.2 45.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
2.0 36.1 GO:0043194 axon initial segment(GO:0043194)
1.9 29.0 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
1.7 16.5 GO:0045180 basal cortex(GO:0045180)
1.6 21.4 GO:0035253 ciliary rootlet(GO:0035253)
1.6 34.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.6 328.9 GO:0032993 protein-DNA complex(GO:0032993)
1.5 4.6 GO:0005592 collagen type XI trimer(GO:0005592)
1.4 7.0 GO:0032444 activin responsive factor complex(GO:0032444)
1.2 22.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
1.1 20.3 GO:0005922 connexon complex(GO:0005922)
1.1 10.0 GO:0032591 dendritic spine membrane(GO:0032591)
1.1 27.4 GO:0097546 ciliary base(GO:0097546)
1.1 76.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.1 2.1 GO:0005955 calcineurin complex(GO:0005955)
1.1 10.5 GO:0097433 dense body(GO:0097433)
1.0 8.1 GO:0005579 membrane attack complex(GO:0005579)
1.0 4.9 GO:0032280 symmetric synapse(GO:0032280)
1.0 4.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.9 300.9 GO:0060076 excitatory synapse(GO:0060076)
0.9 4.7 GO:0072534 perineuronal net(GO:0072534)
0.9 10.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.9 237.1 GO:0005802 trans-Golgi network(GO:0005802)
0.9 9.0 GO:0043596 nuclear replication fork(GO:0043596)
0.9 6.3 GO:0071565 nBAF complex(GO:0071565)
0.9 12.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.8 2.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.8 128.8 GO:0031225 anchored component of membrane(GO:0031225)
0.7 172.3 GO:0043209 myelin sheath(GO:0043209)
0.7 3.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.7 10.5 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.7 162.2 GO:0098794 postsynapse(GO:0098794)
0.7 5.9 GO:0005614 interstitial matrix(GO:0005614)
0.6 9.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.6 6.3 GO:0030673 axolemma(GO:0030673)
0.6 3.1 GO:0043198 dendritic shaft(GO:0043198)
0.6 4.3 GO:0016342 catenin complex(GO:0016342)
0.6 75.2 GO:0030427 site of polarized growth(GO:0030427)
0.6 1.8 GO:0014802 terminal cisterna(GO:0014802)
0.6 3.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.5 61.6 GO:0030018 Z disc(GO:0030018)
0.5 5.7 GO:0030137 COPI-coated vesicle(GO:0030137)
0.5 2.0 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.5 2.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.5 10.0 GO:0048786 presynaptic active zone(GO:0048786)
0.5 6.9 GO:0000124 SAGA complex(GO:0000124)
0.5 3.8 GO:0030478 actin cap(GO:0030478)
0.5 10.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.4 2.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.4 9.0 GO:0035371 microtubule plus-end(GO:0035371)
0.4 1.9 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.4 28.9 GO:0043204 perikaryon(GO:0043204)
0.4 2.3 GO:0097209 epidermal lamellar body(GO:0097209)
0.4 2.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.4 4.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.4 19.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 4.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 4.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 13.3 GO:0034707 chloride channel complex(GO:0034707)
0.3 3.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 0.9 GO:0060198 clathrin-sculpted vesicle(GO:0060198) clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.3 13.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 22.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.3 2.4 GO:0071438 invadopodium membrane(GO:0071438)
0.3 1.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 5.1 GO:0005657 replication fork(GO:0005657)
0.3 3.0 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128)
0.2 11.9 GO:0005771 multivesicular body(GO:0005771)
0.2 2.7 GO:0005921 gap junction(GO:0005921)
0.2 8.3 GO:0030133 transport vesicle(GO:0030133)
0.2 12.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 6.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 49.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 3.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 1.5 GO:0097060 synaptic membrane(GO:0097060)
0.2 1.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 1.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 15.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 22.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 60.8 GO:0043005 neuron projection(GO:0043005)
0.1 140.8 GO:0005694 chromosome(GO:0005694)
0.1 5.7 GO:0015030 Cajal body(GO:0015030)
0.1 2.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 22.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 18.1 GO:0005770 late endosome(GO:0005770)
0.1 24.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 3.4 GO:0034451 centriolar satellite(GO:0034451)
0.1 39.0 GO:0045202 synapse(GO:0045202)
0.1 10.9 GO:0030027 lamellipodium(GO:0030027)
0.1 3.8 GO:0016235 aggresome(GO:0016235)
0.1 9.6 GO:0005814 centriole(GO:0005814)
0.1 1.3 GO:0097225 sperm midpiece(GO:0097225)
0.1 3.4 GO:0005581 collagen trimer(GO:0005581)
0.1 4.4 GO:0005604 basement membrane(GO:0005604)
0.1 2.4 GO:0036126 sperm flagellum(GO:0036126)
0.1 8.7 GO:0031968 organelle outer membrane(GO:0031968)
0.1 2.8 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 5.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 155.8 GO:0016021 integral component of membrane(GO:0016021)
0.0 1.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0031674 I band(GO:0031674)
0.0 0.4 GO:0031904 endosome lumen(GO:0031904)
0.0 1.0 GO:0030139 endocytic vesicle(GO:0030139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
21.6 453.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
18.2 91.1 GO:0030348 syntaxin-3 binding(GO:0030348)
12.3 98.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
8.8 210.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
8.6 146.7 GO:0003680 AT DNA binding(GO:0003680)
7.5 30.1 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
7.5 44.8 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
5.9 95.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
5.7 22.8 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
5.5 22.1 GO:0005334 norepinephrine:sodium symporter activity(GO:0005334)
4.8 28.6 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
4.7 14.1 GO:0019959 interleukin-8 binding(GO:0019959)
4.6 13.8 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
4.4 115.2 GO:0002162 dystroglycan binding(GO:0002162)
3.9 23.6 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
3.9 35.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
3.6 146.7 GO:0017091 AU-rich element binding(GO:0017091)
3.6 28.5 GO:0050816 phosphothreonine binding(GO:0050816)
3.5 13.8 GO:1990430 extracellular matrix protein binding(GO:1990430)
3.4 27.3 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
3.3 13.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
3.3 3.3 GO:0070052 collagen V binding(GO:0070052)
3.1 31.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
3.1 43.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
2.9 8.8 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
2.9 41.0 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
2.9 75.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
2.9 26.1 GO:0046935 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
2.8 95.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.7 16.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.6 160.6 GO:0030507 spectrin binding(GO:0030507)
2.5 15.0 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
2.5 12.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
2.5 9.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
2.4 12.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
2.3 164.0 GO:0070412 R-SMAD binding(GO:0070412)
2.2 6.7 GO:0001596 angiotensin type I receptor activity(GO:0001596)
2.2 104.8 GO:0046875 ephrin receptor binding(GO:0046875)
2.1 34.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
2.1 14.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
2.0 169.9 GO:0050840 extracellular matrix binding(GO:0050840)
1.9 11.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.9 1.9 GO:0071253 connexin binding(GO:0071253)
1.9 17.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
1.9 20.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
1.9 363.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.8 14.8 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
1.8 38.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.7 55.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.7 11.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
1.7 5.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.7 21.8 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.6 177.7 GO:0005262 calcium channel activity(GO:0005262)
1.6 25.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
1.5 4.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
1.5 15.0 GO:0004064 arylesterase activity(GO:0004064)
1.5 44.2 GO:0005212 structural constituent of eye lens(GO:0005212)
1.4 5.8 GO:0008142 oxysterol binding(GO:0008142)
1.4 7.2 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
1.4 22.5 GO:0031432 titin binding(GO:0031432)
1.3 8.1 GO:0004359 glutaminase activity(GO:0004359)
1.3 15.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
1.2 5.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.2 24.8 GO:0051010 microtubule plus-end binding(GO:0051010)
1.2 7.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
1.2 38.3 GO:0008066 glutamate receptor activity(GO:0008066)
1.2 35.3 GO:0017080 sodium channel regulator activity(GO:0017080)
1.2 7.3 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.2 8.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
1.2 3.5 GO:0017098 sulfonylurea receptor binding(GO:0017098)
1.2 54.3 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
1.2 4.6 GO:0005148 prolactin receptor binding(GO:0005148)
1.1 34.5 GO:0017075 syntaxin-1 binding(GO:0017075)
1.1 11.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
1.1 9.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
1.1 2.1 GO:0005137 interleukin-5 receptor binding(GO:0005137)
1.0 12.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
1.0 7.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
1.0 2.0 GO:0004660 protein farnesyltransferase activity(GO:0004660)
1.0 3.0 GO:0032093 SAM domain binding(GO:0032093)
0.9 182.3 GO:0044325 ion channel binding(GO:0044325)
0.9 5.7 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.9 14.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.9 2.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.9 6.5 GO:0001515 opioid peptide activity(GO:0001515)
0.9 6.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.9 3.6 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.9 4.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.9 27.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.9 1.7 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.9 28.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.9 21.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.8 11.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.8 14.0 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.8 9.0 GO:0036310 annealing helicase activity(GO:0036310)
0.8 9.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.8 6.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.8 16.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.8 15.9 GO:0071837 HMG box domain binding(GO:0071837)
0.8 7.5 GO:0022821 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.7 24.4 GO:0015248 sterol transporter activity(GO:0015248)
0.7 11.1 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.7 2.2 GO:0030305 heparanase activity(GO:0030305)
0.7 3.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.7 8.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.7 8.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.7 4.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.7 4.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.7 2.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.7 10.1 GO:0004000 adenosine deaminase activity(GO:0004000)
0.7 11.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.7 3.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.7 3.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.7 5.3 GO:0005243 gap junction channel activity(GO:0005243)
0.7 110.9 GO:0005057 receptor signaling protein activity(GO:0005057)
0.7 185.3 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.7 50.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.7 15.7 GO:0005523 tropomyosin binding(GO:0005523)
0.6 3.2 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.6 7.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.6 4.5 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.6 1.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 23.1 GO:0030552 cAMP binding(GO:0030552)
0.6 5.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.6 16.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.6 22.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.6 11.6 GO:0030506 ankyrin binding(GO:0030506)
0.6 1.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.6 1.7 GO:0055100 adiponectin binding(GO:0055100)
0.6 2.9 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.6 1.7 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.6 3.9 GO:0008046 axon guidance receptor activity(GO:0008046)
0.6 34.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.5 1.6 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.5 4.4 GO:0070410 co-SMAD binding(GO:0070410)
0.5 8.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.5 5.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.5 5.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.5 56.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 8.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 4.6 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.5 7.1 GO:0001968 fibronectin binding(GO:0001968)
0.5 2.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.5 4.3 GO:0035198 miRNA binding(GO:0035198)
0.5 3.6 GO:0016015 morphogen activity(GO:0016015)
0.4 3.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.4 2.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.4 6.0 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.4 48.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.4 78.4 GO:0051015 actin filament binding(GO:0051015)
0.4 1.6 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.4 3.9 GO:0019534 toxin transporter activity(GO:0019534)
0.4 4.5 GO:0008199 ferric iron binding(GO:0008199)
0.4 1.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.4 1.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.4 1.1 GO:0052815 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
0.4 62.8 GO:0005516 calmodulin binding(GO:0005516)
0.3 2.3 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.3 3.6 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.3 1.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 0.9 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.3 2.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.3 12.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 7.9 GO:0042056 chemoattractant activity(GO:0042056)
0.3 32.8 GO:0001618 virus receptor activity(GO:0001618)
0.3 2.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 4.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 3.6 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.3 0.5 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.3 1.6 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.3 3.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 12.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.3 7.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.3 3.6 GO:0031419 cobalamin binding(GO:0031419)
0.3 13.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 7.3 GO:0003785 actin monomer binding(GO:0003785)
0.2 11.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.2 5.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 1.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 5.1 GO:0071949 FAD binding(GO:0071949)
0.2 64.2 GO:0015631 tubulin binding(GO:0015631)
0.2 1.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 7.2 GO:0003774 motor activity(GO:0003774)
0.2 3.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 1.0 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.2 1.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.2 1.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 1.1 GO:0031433 telethonin binding(GO:0031433)
0.2 2.9 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.2 8.7 GO:0008009 chemokine activity(GO:0008009)
0.2 3.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 1.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.2 20.6 GO:0008201 heparin binding(GO:0008201)
0.2 4.2 GO:0003951 NAD+ kinase activity(GO:0003951)
0.2 1.0 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.2 6.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 0.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 3.9 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 2.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 20.1 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.3 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.6 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 8.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 2.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 3.0 GO:0016248 channel inhibitor activity(GO:0016248)
0.1 3.6 GO:0005109 frizzled binding(GO:0005109)
0.1 0.7 GO:0042301 phosphate ion binding(GO:0042301)
0.1 4.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 12.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 2.1 GO:0001848 complement binding(GO:0001848)
0.1 3.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 30.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 6.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 8.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 3.1 GO:0043022 ribosome binding(GO:0043022)
0.1 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 3.0 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 38.0 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.9 GO:0001671 ATPase activator activity(GO:0001671)
0.1 3.6 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 0.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 0.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0030955 potassium ion binding(GO:0030955)
0.0 2.8 GO:0005254 chloride channel activity(GO:0005254)
0.0 4.4 GO:0004519 endonuclease activity(GO:0004519)
0.0 2.3 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.8 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 301.2 PID AR PATHWAY Coregulation of Androgen receptor activity
2.3 148.9 PID NCADHERIN PATHWAY N-cadherin signaling events
2.0 123.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
1.9 118.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.9 112.9 SIG CD40PATHWAYMAP Genes related to CD40 signaling
1.8 134.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
1.1 74.7 PID FGF PATHWAY FGF signaling pathway
1.1 34.0 PID IL3 PATHWAY IL3-mediated signaling events
0.9 74.9 PID LKB1 PATHWAY LKB1 signaling events
0.9 21.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.9 81.1 PID CDC42 PATHWAY CDC42 signaling events
0.9 32.7 PID MYC PATHWAY C-MYC pathway
0.7 12.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.7 30.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.7 25.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.6 10.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.6 5.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.6 36.8 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.6 27.3 SIG CHEMOTAXIS Genes related to chemotaxis
0.6 36.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.6 10.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.5 7.6 PID AP1 PATHWAY AP-1 transcription factor network
0.5 31.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.4 2.1 PID IL5 PATHWAY IL5-mediated signaling events
0.4 3.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.3 3.6 PID EPO PATHWAY EPO signaling pathway
0.3 13.9 PID FAS PATHWAY FAS (CD95) signaling pathway
0.3 10.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.3 24.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.3 26.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 17.4 PID BMP PATHWAY BMP receptor signaling
0.3 11.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.3 9.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 16.0 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.3 2.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 8.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 7.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 7.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 8.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 3.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.2 6.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.2 2.1 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.2 28.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 1.5 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 0.9 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 5.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 2.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 1.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 28.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 21.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 8.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.1 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.1 PID IGF1 PATHWAY IGF1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 592.5 REACTOME MYOGENESIS Genes involved in Myogenesis
6.6 144.7 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
4.7 178.9 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
3.8 102.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
3.6 93.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
3.1 124.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
2.7 71.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
2.5 106.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.8 71.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
1.8 3.6 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
1.7 26.6 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
1.4 5.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.4 20.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
1.3 45.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
1.3 26.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.3 13.8 REACTOME OPSINS Genes involved in Opsins
1.2 8.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
1.1 20.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
1.1 8.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
1.0 26.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
1.0 22.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
1.0 21.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.9 19.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.9 11.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.9 68.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.9 15.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.9 10.7 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.8 31.9 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.8 59.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.8 1.6 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.8 29.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.7 128.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.7 18.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.6 24.7 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.6 17.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.5 34.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.5 12.3 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.5 9.0 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5 4.6 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.5 12.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.4 4.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.4 3.9 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
0.4 7.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 18.0 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.4 16.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.4 8.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 3.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.3 1.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.3 10.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 16.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.3 3.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.3 7.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 4.9 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.3 8.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.2 7.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 2.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 3.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 3.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 5.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 18.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 20.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 3.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 1.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 6.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 4.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 4.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 6.6 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 3.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 15.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.4 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 3.1 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.1 5.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 4.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 13.6 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 1.6 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 1.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 1.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 5.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 3.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors