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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXB6_PRRX2
Z-value: 7.91
Motif logo
Transcription factors associated with HOXB6_PRRX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HOXB6
|
ENSG00000108511.10 | HOXB6 |
|
PRRX2
|
ENSG00000167157.11 | PRRX2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRRX2 | hg38_v1_chr9_+_129665603_129665672 | 0.52 | 3.0e-16 | Click! |
| HOXB6 | hg38_v1_chr17_-_48604959_48605000 | -0.08 | 2.5e-01 | Click! |
Activity profile of HOXB6_PRRX2 motif
Sorted Z-values of HOXB6_PRRX2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB6_PRRX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 79.8 | 558.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 30.4 | 91.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 19.1 | 210.3 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 16.8 | 134.6 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 13.7 | 136.6 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 13.7 | 54.6 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 10.4 | 31.2 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 10.0 | 129.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 9.1 | 27.4 | GO:0060873 | subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875) |
| 8.6 | 34.4 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 8.6 | 34.3 | GO:1903860 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 8.5 | 25.4 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
| 8.3 | 8.3 | GO:0021779 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 8.2 | 32.7 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 7.9 | 282.9 | GO:0048665 | neuron fate specification(GO:0048665) |
| 7.1 | 28.5 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 6.6 | 33.1 | GO:0021764 | amygdala development(GO:0021764) |
| 6.5 | 13.1 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 6.3 | 107.7 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 6.2 | 74.1 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 6.0 | 60.3 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 6.0 | 161.0 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 5.7 | 28.6 | GO:0007412 | axon target recognition(GO:0007412) |
| 5.7 | 34.0 | GO:0097338 | response to clozapine(GO:0097338) |
| 5.7 | 45.3 | GO:0021767 | mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 5.5 | 16.5 | GO:1903422 | negative regulation of synaptic vesicle recycling(GO:1903422) negative regulation of membrane invagination(GO:1905154) |
| 5.3 | 26.4 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 5.1 | 15.3 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582) |
| 5.1 | 40.6 | GO:0098814 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 4.9 | 14.6 | GO:0060435 | bronchiole development(GO:0060435) |
| 4.7 | 4.7 | GO:0048690 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 4.7 | 14.1 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 4.4 | 8.8 | GO:0072275 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 4.1 | 45.3 | GO:2000795 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 4.1 | 40.8 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 4.0 | 27.9 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 3.9 | 3.9 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 3.9 | 143.6 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 3.8 | 45.2 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 3.7 | 18.5 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 3.7 | 29.5 | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 3.4 | 85.9 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 3.4 | 95.4 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 3.3 | 13.1 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 3.3 | 32.5 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 3.2 | 6.5 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 3.1 | 129.7 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 3.1 | 9.2 | GO:0014873 | response to muscle activity involved in regulation of muscle adaptation(GO:0014873) |
| 3.0 | 9.0 | GO:0036292 | DNA rewinding(GO:0036292) |
| 2.8 | 5.6 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 2.8 | 46.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 2.7 | 2.7 | GO:1902725 | negative regulation of satellite cell differentiation(GO:1902725) |
| 2.7 | 19.2 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 2.7 | 29.7 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 2.7 | 8.0 | GO:0060018 | astrocyte fate commitment(GO:0060018) |
| 2.7 | 31.9 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 2.6 | 21.1 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 2.6 | 193.5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 2.6 | 12.8 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 2.5 | 47.7 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 2.4 | 31.7 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 2.4 | 155.5 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 2.4 | 12.1 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
| 2.4 | 2.4 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
| 2.3 | 11.7 | GO:0061032 | cardiac right ventricle formation(GO:0003219) visceral serous pericardium development(GO:0061032) |
| 2.3 | 105.5 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 2.3 | 16.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 2.3 | 21.0 | GO:0008354 | germ cell migration(GO:0008354) |
| 2.3 | 30.1 | GO:2000394 | positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 2.3 | 20.8 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 2.3 | 9.2 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 2.3 | 59.7 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 2.3 | 2.3 | GO:0042640 | anagen(GO:0042640) |
| 2.2 | 11.2 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
| 2.2 | 8.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 2.2 | 8.6 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 2.1 | 6.4 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 2.1 | 10.3 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 2.0 | 12.2 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 2.0 | 19.9 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
| 2.0 | 7.9 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 1.9 | 3.9 | GO:1902285 | sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) |
| 1.9 | 19.3 | GO:0021681 | cerebellar granular layer development(GO:0021681) |
| 1.9 | 30.8 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 1.9 | 21.2 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 1.9 | 1.9 | GO:1902232 | regulation of positive thymic T cell selection(GO:1902232) |
| 1.9 | 93.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 1.9 | 5.7 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 1.9 | 32.0 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 1.8 | 5.5 | GO:1990418 | response to insulin-like growth factor stimulus(GO:1990418) |
| 1.8 | 7.3 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 1.8 | 5.5 | GO:0016103 | diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) |
| 1.8 | 3.6 | GO:0021514 | ventral spinal cord interneuron differentiation(GO:0021514) |
| 1.8 | 3.6 | GO:1900145 | regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900175) |
| 1.8 | 7.2 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 1.8 | 7.0 | GO:0048318 | axial mesoderm development(GO:0048318) |
| 1.8 | 12.3 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731) |
| 1.8 | 10.6 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 1.7 | 5.1 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 1.7 | 6.7 | GO:0086097 | phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097) |
| 1.7 | 21.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 1.7 | 3.3 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
| 1.7 | 6.7 | GO:1902159 | regulation of cyclic nucleotide-gated ion channel activity(GO:1902159) |
| 1.7 | 10.0 | GO:1990034 | calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034) |
| 1.7 | 8.3 | GO:0060054 | positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054) |
| 1.6 | 6.5 | GO:2000504 | positive regulation of blood vessel remodeling(GO:2000504) |
| 1.6 | 6.5 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 1.6 | 21.1 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 1.6 | 4.8 | GO:0072674 | macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 1.6 | 27.0 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 1.6 | 3.2 | GO:0007356 | thorax and anterior abdomen determination(GO:0007356) |
| 1.6 | 14.1 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 1.6 | 18.7 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 1.5 | 6.2 | GO:0048294 | negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 1.5 | 3.1 | GO:0030035 | microspike assembly(GO:0030035) |
| 1.5 | 4.6 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 1.5 | 4.6 | GO:0035502 | metanephric part of ureteric bud development(GO:0035502) |
| 1.5 | 6.0 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 1.5 | 1.5 | GO:0061152 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 1.4 | 5.8 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 1.4 | 27.1 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 1.4 | 12.8 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 1.4 | 11.0 | GO:0061709 | reticulophagy(GO:0061709) |
| 1.4 | 26.1 | GO:1900103 | positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103) |
| 1.4 | 378.0 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.3 | 8.1 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 1.3 | 4.0 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
| 1.3 | 2.6 | GO:0002309 | T cell proliferation involved in immune response(GO:0002309) |
| 1.3 | 92.8 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 1.3 | 7.7 | GO:0060594 | mammary gland specification(GO:0060594) |
| 1.3 | 2.5 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 1.3 | 16.6 | GO:0006554 | lysine catabolic process(GO:0006554) |
| 1.3 | 6.3 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 1.2 | 3.7 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099) |
| 1.2 | 3.7 | GO:0033082 | regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654) |
| 1.2 | 5.0 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.2 | 2.5 | GO:0060298 | positive regulation of sarcomere organization(GO:0060298) |
| 1.2 | 8.5 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 1.2 | 2.4 | GO:0021571 | rhombomere 5 development(GO:0021571) |
| 1.2 | 2.4 | GO:0097325 | melanocyte proliferation(GO:0097325) |
| 1.2 | 3.5 | GO:0072233 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
| 1.2 | 4.7 | GO:0042441 | eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) |
| 1.2 | 16.2 | GO:0061162 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 1.2 | 37.1 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 1.1 | 4.6 | GO:0060023 | soft palate development(GO:0060023) |
| 1.1 | 8.0 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 1.1 | 56.8 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 1.1 | 5.7 | GO:0016926 | protein desumoylation(GO:0016926) |
| 1.1 | 4.5 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 1.1 | 9.0 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 1.1 | 12.8 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 1.1 | 5.3 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 1.0 | 4.2 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 1.0 | 4.2 | GO:0036269 | swimming behavior(GO:0036269) |
| 1.0 | 87.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 1.0 | 3.1 | GO:0097272 | ammonia homeostasis(GO:0097272) |
| 1.0 | 11.2 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 1.0 | 7.1 | GO:0015811 | L-cystine transport(GO:0015811) |
| 1.0 | 7.0 | GO:0090324 | negative regulation of oxidative phosphorylation(GO:0090324) |
| 1.0 | 7.0 | GO:0070166 | enamel mineralization(GO:0070166) |
| 1.0 | 6.0 | GO:0071477 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 1.0 | 22.1 | GO:0015874 | norepinephrine transport(GO:0015874) |
| 1.0 | 58.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 1.0 | 1.9 | GO:0086053 | SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053) |
| 1.0 | 3.8 | GO:0050916 | sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917) |
| 1.0 | 5.7 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
| 1.0 | 5.7 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 1.0 | 2.9 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.9 | 6.5 | GO:0036343 | psychomotor behavior(GO:0036343) motor behavior(GO:0061744) |
| 0.9 | 4.6 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.9 | 4.6 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
| 0.9 | 143.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.9 | 2.7 | GO:0061743 | motor learning(GO:0061743) |
| 0.9 | 21.6 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.9 | 4.5 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.9 | 3.6 | GO:0001519 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 0.9 | 37.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.9 | 7.1 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.9 | 31.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.9 | 0.9 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.9 | 4.4 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
| 0.9 | 13.8 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.8 | 7.5 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.8 | 4.1 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.8 | 7.4 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263) |
| 0.8 | 4.9 | GO:0060484 | lung-associated mesenchyme development(GO:0060484) |
| 0.8 | 12.2 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.8 | 3.3 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.8 | 6.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.8 | 24.7 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.8 | 9.4 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.8 | 3.1 | GO:0071286 | cellular response to magnesium ion(GO:0071286) |
| 0.8 | 6.9 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.8 | 16.7 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.8 | 6.8 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.8 | 6.0 | GO:0015824 | proline transport(GO:0015824) |
| 0.8 | 2.3 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
| 0.7 | 1.5 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.7 | 6.0 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) |
| 0.7 | 9.6 | GO:0035878 | nail development(GO:0035878) |
| 0.7 | 39.8 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.7 | 2.2 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.7 | 1.5 | GO:0060133 | somatotropin secreting cell development(GO:0060133) |
| 0.7 | 2.2 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.7 | 3.6 | GO:0010748 | regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
| 0.7 | 4.9 | GO:0060013 | righting reflex(GO:0060013) |
| 0.7 | 25.2 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.7 | 4.1 | GO:0050955 | thermoception(GO:0050955) |
| 0.7 | 6.6 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.7 | 26.1 | GO:0086010 | membrane depolarization during action potential(GO:0086010) |
| 0.6 | 3.1 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.6 | 3.1 | GO:0031069 | hair follicle morphogenesis(GO:0031069) |
| 0.6 | 3.0 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.6 | 3.6 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.6 | 16.5 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.6 | 3.5 | GO:0021781 | glial cell fate commitment(GO:0021781) |
| 0.6 | 0.6 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.6 | 5.3 | GO:0015865 | purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868) |
| 0.6 | 2.9 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.6 | 4.6 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.6 | 10.9 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.6 | 2.3 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.6 | 2.8 | GO:0071670 | smooth muscle cell chemotaxis(GO:0071670) |
| 0.6 | 25.0 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.6 | 6.1 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.5 | 6.5 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.5 | 1.6 | GO:0043416 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.5 | 2.1 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.5 | 3.2 | GO:0035865 | cellular response to potassium ion(GO:0035865) |
| 0.5 | 5.3 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.5 | 6.8 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.5 | 2.1 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.5 | 16.1 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.5 | 8.2 | GO:0016048 | detection of temperature stimulus(GO:0016048) sensory perception of temperature stimulus(GO:0050951) |
| 0.5 | 2.0 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.5 | 8.1 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.5 | 10.0 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.5 | 15.5 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.5 | 16.3 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.4 | 6.3 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.4 | 7.6 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.4 | 4.4 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.4 | 31.9 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.4 | 3.9 | GO:1902109 | negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109) |
| 0.4 | 8.5 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.4 | 3.4 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.4 | 2.9 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
| 0.4 | 5.8 | GO:0097152 | mesenchymal cell apoptotic process(GO:0097152) |
| 0.4 | 2.1 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.4 | 3.6 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.4 | 3.1 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.4 | 5.2 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.4 | 5.5 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.4 | 4.7 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.4 | 18.5 | GO:1903779 | regulation of cardiac conduction(GO:1903779) |
| 0.4 | 27.7 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.4 | 4.2 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.4 | 2.8 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.4 | 4.2 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.4 | 2.1 | GO:0032815 | negative regulation of natural killer cell activation(GO:0032815) |
| 0.4 | 1.8 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.3 | 65.4 | GO:0007411 | axon guidance(GO:0007411) |
| 0.3 | 1.7 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.3 | 1.7 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.3 | 3.4 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.3 | 15.9 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.3 | 4.5 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.3 | 1.0 | GO:0016999 | antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) |
| 0.3 | 1.6 | GO:0006127 | glycerophosphate shuttle(GO:0006127) |
| 0.3 | 1.5 | GO:0030070 | insulin processing(GO:0030070) |
| 0.3 | 1.5 | GO:1901529 | positive regulation of anion channel activity(GO:1901529) |
| 0.3 | 2.4 | GO:0015747 | urate transport(GO:0015747) |
| 0.3 | 7.2 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.3 | 2.4 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.3 | 1.2 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) |
| 0.3 | 5.1 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.3 | 4.5 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.3 | 3.8 | GO:0010991 | regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.3 | 7.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.2 | 30.9 | GO:0019722 | calcium-mediated signaling(GO:0019722) |
| 0.2 | 5.7 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.2 | 13.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 3.6 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.2 | 1.8 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.2 | 1.7 | GO:0010832 | negative regulation of myotube differentiation(GO:0010832) |
| 0.2 | 5.4 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.2 | 1.5 | GO:0001865 | NK T cell differentiation(GO:0001865) |
| 0.2 | 1.7 | GO:0042908 | xenobiotic transport(GO:0042908) |
| 0.2 | 3.8 | GO:0021591 | ventricular system development(GO:0021591) |
| 0.2 | 0.4 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.2 | 1.3 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.2 | 8.4 | GO:1901998 | toxin transport(GO:1901998) |
| 0.2 | 1.2 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.2 | 12.3 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.2 | 2.3 | GO:1903859 | regulation of dendrite extension(GO:1903859) |
| 0.2 | 2.7 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 0.2 | 3.0 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.2 | 0.9 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.2 | 0.5 | GO:0060197 | cloacal septation(GO:0060197) |
| 0.2 | 4.7 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.2 | 2.7 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.2 | 1.9 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.2 | 1.4 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.2 | 0.6 | GO:0001692 | histamine metabolic process(GO:0001692) |
| 0.2 | 0.9 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.2 | 2.1 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.2 | 9.7 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.1 | 2.1 | GO:0090278 | negative regulation of insulin secretion(GO:0046676) negative regulation of peptide hormone secretion(GO:0090278) |
| 0.1 | 1.7 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 5.9 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.1 | 1.1 | GO:0061298 | retina vasculature development in camera-type eye(GO:0061298) |
| 0.1 | 3.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 1.7 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
| 0.1 | 2.2 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 1.6 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.1 | 2.2 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.1 | 12.1 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 2.7 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.1 | 0.8 | GO:0070141 | response to UV-A(GO:0070141) cellular response to UV-A(GO:0071492) |
| 0.1 | 0.3 | GO:2000342 | ERK5 cascade(GO:0070375) negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342) |
| 0.1 | 2.4 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 1.3 | GO:0032232 | negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497) |
| 0.1 | 3.5 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.1 | 0.3 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
| 0.1 | 8.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 0.1 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.1 | 3.0 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 0.7 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.1 | 0.5 | GO:0045657 | positive regulation of monocyte differentiation(GO:0045657) |
| 0.1 | 0.5 | GO:0002933 | lipid hydroxylation(GO:0002933) |
| 0.1 | 1.2 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.1 | 2.0 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.1 | 1.6 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.1 | 0.7 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 3.0 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.1 | 1.8 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.1 | 4.6 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.1 | 0.5 | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation(GO:0010801) |
| 0.1 | 0.3 | GO:0072502 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.1 | 1.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 0.8 | GO:0034374 | low-density lipoprotein particle remodeling(GO:0034374) |
| 0.1 | 1.3 | GO:0035825 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.1 | 1.9 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 0.4 | GO:0045655 | regulation of monocyte differentiation(GO:0045655) |
| 0.0 | 1.0 | GO:0048536 | spleen development(GO:0048536) |
| 0.0 | 0.6 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.2 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 0.3 | GO:0007379 | segment specification(GO:0007379) |
| 0.0 | 1.7 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.0 | 1.6 | GO:0001958 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 2.8 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.0 | 0.7 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 6.2 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 1.1 | GO:0002548 | monocyte chemotaxis(GO:0002548) |
| 0.0 | 1.1 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.0 | 0.9 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 0.0 | 0.1 | GO:0070409 | carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) cellular response to oleic acid(GO:0071400) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718) |
| 0.0 | 0.1 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.0 | 0.1 | GO:0042090 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.0 | 3.3 | GO:0007568 | aging(GO:0007568) |
| 0.0 | 0.8 | GO:0009060 | aerobic respiration(GO:0009060) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.7 | 95.0 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 18.2 | 91.1 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 9.7 | 126.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 9.0 | 72.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 8.0 | 31.9 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 6.6 | 33.2 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 6.5 | 26.1 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 6.2 | 154.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 6.0 | 23.9 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 5.7 | 22.8 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 4.7 | 18.8 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 4.7 | 32.7 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 4.4 | 177.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 4.2 | 20.8 | GO:0031673 | H zone(GO:0031673) |
| 4.1 | 102.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 3.5 | 205.3 | GO:0031430 | M band(GO:0031430) |
| 3.5 | 41.7 | GO:0016013 | syntrophin complex(GO:0016013) |
| 3.3 | 16.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 2.6 | 13.2 | GO:0032584 | growth cone membrane(GO:0032584) |
| 2.5 | 299.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 2.4 | 43.1 | GO:0031045 | dense core granule(GO:0031045) |
| 2.3 | 72.1 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 2.2 | 45.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 2.0 | 36.1 | GO:0043194 | axon initial segment(GO:0043194) |
| 1.9 | 29.0 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 1.7 | 16.5 | GO:0045180 | basal cortex(GO:0045180) |
| 1.6 | 21.4 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 1.6 | 34.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 1.6 | 328.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 1.5 | 4.6 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 1.4 | 7.0 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 1.2 | 22.3 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 1.1 | 20.3 | GO:0005922 | connexon complex(GO:0005922) |
| 1.1 | 10.0 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 1.1 | 27.4 | GO:0097546 | ciliary base(GO:0097546) |
| 1.1 | 76.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 1.1 | 2.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 1.1 | 10.5 | GO:0097433 | dense body(GO:0097433) |
| 1.0 | 8.1 | GO:0005579 | membrane attack complex(GO:0005579) |
| 1.0 | 4.9 | GO:0032280 | symmetric synapse(GO:0032280) |
| 1.0 | 4.8 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.9 | 300.9 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.9 | 4.7 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.9 | 10.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.9 | 237.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.9 | 9.0 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.9 | 6.3 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.9 | 12.3 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.8 | 2.4 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.8 | 128.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.7 | 172.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.7 | 3.6 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.7 | 10.5 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.7 | 162.2 | GO:0098794 | postsynapse(GO:0098794) |
| 0.7 | 5.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.6 | 9.0 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.6 | 6.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.6 | 3.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.6 | 4.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.6 | 75.2 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.6 | 1.8 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.6 | 3.9 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.5 | 61.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 5.7 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.5 | 2.0 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.5 | 2.5 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.5 | 10.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.5 | 6.9 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.5 | 3.8 | GO:0030478 | actin cap(GO:0030478) |
| 0.5 | 10.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.4 | 2.7 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.4 | 9.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.4 | 1.9 | GO:0000835 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.4 | 28.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.4 | 2.3 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.4 | 2.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.4 | 4.3 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.4 | 19.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.3 | 4.9 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.3 | 4.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.3 | 13.3 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.3 | 3.2 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.3 | 0.9 | GO:0060198 | clathrin-sculpted vesicle(GO:0060198) clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083) |
| 0.3 | 13.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.3 | 22.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.3 | 2.4 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.3 | 1.6 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.3 | 5.1 | GO:0005657 | replication fork(GO:0005657) |
| 0.3 | 3.0 | GO:0030128 | clathrin coat of endocytic vesicle(GO:0030128) |
| 0.2 | 11.9 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.2 | 2.7 | GO:0005921 | gap junction(GO:0005921) |
| 0.2 | 8.3 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.2 | 12.1 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.2 | 6.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 49.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 3.0 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.2 | 1.5 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.2 | 1.0 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.2 | 1.1 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.2 | 15.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 22.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 60.8 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 140.8 | GO:0005694 | chromosome(GO:0005694) |
| 0.1 | 5.7 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 2.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 22.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 18.1 | GO:0005770 | late endosome(GO:0005770) |
| 0.1 | 24.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 3.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 39.0 | GO:0045202 | synapse(GO:0045202) |
| 0.1 | 10.9 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 3.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 9.6 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 1.3 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 3.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 4.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 2.4 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.1 | 8.7 | GO:0031968 | organelle outer membrane(GO:0031968) |
| 0.1 | 2.8 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 0.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 5.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.5 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 1.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 155.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 1.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.1 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 0.4 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.0 | 1.0 | GO:0030139 | endocytic vesicle(GO:0030139) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.6 | 453.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 18.2 | 91.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 12.3 | 98.0 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 8.8 | 210.3 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 8.6 | 146.7 | GO:0003680 | AT DNA binding(GO:0003680) |
| 7.5 | 30.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 7.5 | 44.8 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 5.9 | 95.1 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 5.7 | 22.8 | GO:0047298 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
| 5.5 | 22.1 | GO:0005334 | norepinephrine:sodium symporter activity(GO:0005334) |
| 4.8 | 28.6 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 4.7 | 14.1 | GO:0019959 | interleukin-8 binding(GO:0019959) |
| 4.6 | 13.8 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 4.4 | 115.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 3.9 | 23.6 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 3.9 | 35.2 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 3.6 | 146.7 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 3.6 | 28.5 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 3.5 | 13.8 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 3.4 | 27.3 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 3.3 | 13.2 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 3.3 | 3.3 | GO:0070052 | collagen V binding(GO:0070052) |
| 3.1 | 31.5 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 3.1 | 43.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 2.9 | 8.8 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 2.9 | 41.0 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 2.9 | 75.6 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 2.9 | 26.1 | GO:0046935 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 2.8 | 95.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 2.7 | 16.0 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 2.6 | 160.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 2.5 | 15.0 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 2.5 | 12.4 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 2.5 | 9.8 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 2.4 | 12.1 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 2.3 | 164.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 2.2 | 6.7 | GO:0001596 | angiotensin type I receptor activity(GO:0001596) |
| 2.2 | 104.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 2.1 | 34.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 2.1 | 14.4 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 2.0 | 169.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.9 | 11.7 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 1.9 | 1.9 | GO:0071253 | connexin binding(GO:0071253) |
| 1.9 | 17.2 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 1.9 | 20.9 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 1.9 | 363.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.8 | 14.8 | GO:0030345 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 1.8 | 38.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 1.7 | 55.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 1.7 | 11.9 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 1.7 | 5.1 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 1.7 | 21.8 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 1.6 | 177.7 | GO:0005262 | calcium channel activity(GO:0005262) |
| 1.6 | 25.4 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 1.5 | 4.6 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 1.5 | 15.0 | GO:0004064 | arylesterase activity(GO:0004064) |
| 1.5 | 44.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 1.4 | 5.8 | GO:0008142 | oxysterol binding(GO:0008142) |
| 1.4 | 7.2 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
| 1.4 | 22.5 | GO:0031432 | titin binding(GO:0031432) |
| 1.3 | 8.1 | GO:0004359 | glutaminase activity(GO:0004359) |
| 1.3 | 15.1 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 1.2 | 5.0 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 1.2 | 24.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 1.2 | 7.4 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 1.2 | 38.3 | GO:0008066 | glutamate receptor activity(GO:0008066) |
| 1.2 | 35.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 1.2 | 7.3 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 1.2 | 8.5 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 1.2 | 3.5 | GO:0017098 | sulfonylurea receptor binding(GO:0017098) |
| 1.2 | 54.3 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 1.2 | 4.6 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 1.1 | 34.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 1.1 | 11.9 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 1.1 | 9.6 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 1.1 | 2.1 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 1.0 | 12.3 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 1.0 | 7.1 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 1.0 | 2.0 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 1.0 | 3.0 | GO:0032093 | SAM domain binding(GO:0032093) |
| 0.9 | 182.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.9 | 5.7 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.9 | 14.1 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.9 | 2.8 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
| 0.9 | 6.5 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.9 | 6.3 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.9 | 3.6 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.9 | 4.4 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
| 0.9 | 27.8 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.9 | 1.7 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.9 | 28.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.9 | 21.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.8 | 11.6 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.8 | 14.0 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.8 | 9.0 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.8 | 9.0 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.8 | 6.5 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.8 | 16.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.8 | 15.9 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.8 | 7.5 | GO:0022821 | sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821) |
| 0.7 | 24.4 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.7 | 11.1 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.7 | 2.2 | GO:0030305 | heparanase activity(GO:0030305) |
| 0.7 | 3.7 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.7 | 8.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.7 | 8.6 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.7 | 4.9 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.7 | 4.2 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.7 | 2.1 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.7 | 10.1 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.7 | 11.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.7 | 3.4 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.7 | 3.3 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.7 | 5.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.7 | 110.9 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.7 | 185.3 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.7 | 50.4 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.7 | 15.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.6 | 3.2 | GO:0005298 | proline:sodium symporter activity(GO:0005298) |
| 0.6 | 7.7 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.6 | 4.5 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.6 | 1.3 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.6 | 23.1 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.6 | 5.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.6 | 16.5 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.6 | 22.3 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.6 | 11.6 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.6 | 1.7 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.6 | 1.7 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.6 | 2.9 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.6 | 1.7 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.6 | 3.9 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.6 | 34.2 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.5 | 1.6 | GO:0090555 | phosphatidylethanolamine-translocating ATPase activity(GO:0090555) |
| 0.5 | 4.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.5 | 8.1 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.5 | 5.8 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.5 | 5.7 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.5 | 56.6 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.5 | 8.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.5 | 4.6 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.5 | 7.1 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.5 | 2.0 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.5 | 4.3 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.5 | 3.6 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.4 | 3.1 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.4 | 2.1 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.4 | 6.0 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.4 | 48.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.4 | 78.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 1.6 | GO:0052591 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.4 | 3.9 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.4 | 4.5 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.4 | 1.1 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.4 | 1.1 | GO:0005260 | channel-conductance-controlling ATPase activity(GO:0005260) |
| 0.4 | 1.1 | GO:0052815 | medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816) |
| 0.4 | 62.8 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 2.3 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.3 | 3.6 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.3 | 1.2 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.3 | 0.9 | GO:0015222 | serotonin transmembrane transporter activity(GO:0015222) |
| 0.3 | 2.1 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.3 | 12.3 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.3 | 7.9 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.3 | 32.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.3 | 2.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.3 | 4.5 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.3 | 3.6 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.3 | 0.5 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.3 | 1.6 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.3 | 3.0 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.3 | 12.8 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.3 | 7.1 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.3 | 3.6 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.3 | 13.6 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 7.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 11.9 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.2 | 5.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.2 | 1.2 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.2 | 5.1 | GO:0071949 | FAD binding(GO:0071949) |
| 0.2 | 64.2 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.2 | 1.9 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.2 | 7.2 | GO:0003774 | motor activity(GO:0003774) |
| 0.2 | 3.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 1.0 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.2 | 1.5 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.2 | 1.5 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.2 | 1.1 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.2 | 2.9 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.2 | 8.7 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.2 | 3.8 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.2 | 1.2 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.2 | 20.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 4.2 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.2 | 1.0 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.2 | 6.1 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.2 | 0.5 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.2 | 3.9 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.2 | 2.3 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 20.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 0.3 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 0.6 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.1 | 8.2 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 2.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 3.0 | GO:0016248 | channel inhibitor activity(GO:0016248) |
| 0.1 | 3.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 0.7 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.1 | 4.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 12.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 3.7 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.1 | 2.1 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 3.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 1.9 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 0.7 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 2.4 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 30.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 2.0 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.1 | 1.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 6.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 8.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 3.1 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.1 | 1.4 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.1 | 2.1 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 3.0 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.1 | 38.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 0.8 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 1.9 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 3.6 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.1 | 0.7 | GO:0005548 | phospholipid transporter activity(GO:0005548) |
| 0.1 | 0.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 2.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.4 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.0 | 2.8 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 4.4 | GO:0004519 | endonuclease activity(GO:0004519) |
| 0.0 | 2.3 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
| 0.0 | 0.8 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 0.1 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.0 | 0.8 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 0.1 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 0.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 301.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 2.3 | 148.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 2.0 | 123.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 1.9 | 118.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 1.9 | 112.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 1.8 | 134.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 1.1 | 74.7 | PID FGF PATHWAY | FGF signaling pathway |
| 1.1 | 34.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.9 | 74.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.9 | 21.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.9 | 81.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.9 | 32.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.7 | 12.2 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.7 | 30.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.7 | 25.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.6 | 10.1 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.6 | 5.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.6 | 36.8 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.6 | 27.3 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.6 | 36.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.6 | 10.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.5 | 7.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.5 | 31.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.4 | 2.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.4 | 3.5 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.3 | 3.6 | PID EPO PATHWAY | EPO signaling pathway |
| 0.3 | 13.9 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.3 | 10.6 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.3 | 24.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 26.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.3 | 17.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.3 | 11.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.3 | 9.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.3 | 16.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.3 | 2.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.2 | 8.3 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 7.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 7.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 8.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 3.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.2 | 6.4 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.2 | 2.1 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 28.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 1.5 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 2.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 0.9 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 5.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 2.3 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 1.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 28.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 21.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 1.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 8.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 2.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.7 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.1 | PID IGF1 PATHWAY | IGF1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 592.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 6.6 | 144.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 4.7 | 178.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 3.8 | 102.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 3.6 | 93.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 3.1 | 124.2 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 2.7 | 71.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 2.5 | 106.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.8 | 71.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.8 | 3.6 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 1.7 | 26.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 1.4 | 5.7 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 1.4 | 20.5 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 1.3 | 45.3 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 1.3 | 26.2 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 1.3 | 13.8 | REACTOME OPSINS | Genes involved in Opsins |
| 1.2 | 8.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 1.1 | 20.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 1.1 | 8.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 1.0 | 26.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 1.0 | 22.8 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 1.0 | 21.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.9 | 19.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.9 | 11.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.9 | 68.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.9 | 15.3 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.9 | 10.7 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.8 | 31.9 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.8 | 59.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.8 | 1.6 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.8 | 29.2 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.7 | 128.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.7 | 18.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.6 | 24.7 | REACTOME CELL CELL JUNCTION ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.6 | 17.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.5 | 34.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.5 | 12.3 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.5 | 9.0 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.5 | 4.6 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.5 | 12.6 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.4 | 4.5 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.4 | 3.9 | REACTOME SIGNALING BY WNT | Genes involved in Signaling by Wnt |
| 0.4 | 7.4 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.4 | 18.0 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.4 | 16.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.4 | 8.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 3.2 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.3 | 1.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 10.6 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.3 | 16.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 3.2 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.3 | 7.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 4.9 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.3 | 8.8 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.2 | 7.0 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 2.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 3.3 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.2 | 3.1 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.2 | 5.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 18.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 20.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 3.7 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 1.0 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.2 | 6.0 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.2 | 4.6 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 4.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 6.6 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.1 | 3.4 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 1.9 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 15.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 5.4 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.1 | 3.1 | REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
| 0.1 | 5.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 1.1 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.1 | 4.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.1 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 13.6 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 1.6 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 1.3 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.1 | 1.9 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 1.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 5.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 3.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.0 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.6 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 0.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.4 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 1.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.7 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |