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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXC11

Z-value: 4.41

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Transcription factors associated with HOXC11

Gene Symbol Gene ID Gene Info
HOXC11
ENSG00000123388.4 HOXC11

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXC11hg38_v1_chr12_+_53973108_53973140-0.313.1e-06Click!

Activity profile of HOXC11 motif

Sorted Z-values of HOXC11 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC11

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_189179754 35.58 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr11_+_67586104 16.01 ENST00000495996.1
GSTP1
glutathione S-transferase pi 1
chr18_+_3252267 13.08 ENST00000536605.1
ENST00000580887.5
MYL12A
myosin light chain 12A
chr7_+_134779625 12.07 ENST00000454108.5
ENST00000361675.7
CALD1
caldesmon 1
chr7_+_134779663 12.00 ENST00000361901.6
CALD1
caldesmon 1
chr2_-_55917699 11.51 ENST00000634374.1
EFEMP1
EGF containing fibulin extracellular matrix protein 1
chr8_+_26293112 9.98 ENST00000523925.5
ENST00000315985.7
PPP2R2A
protein phosphatase 2 regulatory subunit Balpha
chr7_-_93890160 9.69 ENST00000451238.1
TFPI2
tissue factor pathway inhibitor 2
chr12_-_53677397 9.51 ENST00000338662.6
ENST00000552242.5
ATP5MC2
ATP synthase membrane subunit c locus 2
chr1_-_31919093 9.33 ENST00000602683.5
ENST00000470404.5
PTP4A2
protein tyrosine phosphatase 4A2
chr5_-_111756245 9.12 ENST00000447165.6
NREP
neuronal regeneration related protein
chr5_+_102808057 9.01 ENST00000684043.1
ENST00000682407.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr6_+_12290353 8.93 ENST00000379375.6
EDN1
endothelin 1
chr11_-_11353241 8.61 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr14_+_55661272 7.91 ENST00000555573.5
KTN1
kinectin 1
chr2_-_206159509 7.41 ENST00000423725.5
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr15_-_55249029 6.73 ENST00000566877.5
RAB27A
RAB27A, member RAS oncogene family
chr2_-_206159194 6.61 ENST00000455934.6
ENST00000449699.5
ENST00000454195.1
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr2_+_108588453 6.42 ENST00000393310.5
LIMS1
LIM zinc finger domain containing 1
chr1_-_93681829 6.13 ENST00000260502.11
BCAR3
BCAR3 adaptor protein, NSP family member
chr19_+_35545681 5.85 ENST00000392205.2
TMEM147
transmembrane protein 147
chr19_+_35545575 5.80 ENST00000222284.10
ENST00000392204.6
TMEM147
transmembrane protein 147
chr17_-_79950828 5.68 ENST00000572862.5
ENST00000573782.5
ENST00000574427.1
ENST00000570373.5
ENST00000340848.11
ENST00000576768.5
TBC1D16
TBC1 domain family member 16
chr7_-_151520080 5.55 ENST00000496004.5
RHEB
Ras homolog, mTORC1 binding
chr10_+_17229267 5.54 ENST00000224237.9
VIM
vimentin
chr2_-_175181663 5.51 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP5MC3
ATP synthase membrane subunit c locus 3
chr2_+_27217361 5.48 ENST00000264705.9
ENST00000403525.5
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr17_-_41528293 5.41 ENST00000455635.1
ENST00000361566.7
KRT19
keratin 19
chrX_-_10833643 5.30 ENST00000380785.5
ENST00000380787.5
MID1
midline 1
chr18_+_3252208 5.27 ENST00000578562.6
MYL12A
myosin light chain 12A
chr3_-_79767987 5.25 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr4_-_73223082 4.93 ENST00000509867.6
ANKRD17
ankyrin repeat domain 17
chr18_+_58255433 4.87 ENST00000635997.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr18_-_28177102 4.64 ENST00000413878.2
ENST00000269141.8
CDH2
cadherin 2
chr1_+_167329044 4.38 ENST00000367862.9
POU2F1
POU class 2 homeobox 1
chr19_-_45424364 4.32 ENST00000589165.5
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
chr3_-_37174578 4.21 ENST00000336686.9
LRRFIP2
LRR binding FLII interacting protein 2
chr16_-_2264221 4.15 ENST00000566397.5
RNPS1
RNA binding protein with serine rich domain 1
chr1_+_23019415 4.03 ENST00000465864.2
ENST00000356634.7
ENST00000400181.9
KDM1A
lysine demethylase 1A
chrX_-_132219439 4.02 ENST00000370874.2
RAP2C
RAP2C, member of RAS oncogene family
chrX_-_132219473 3.99 ENST00000620646.4
RAP2C
RAP2C, member of RAS oncogene family
chr7_-_41703062 3.69 ENST00000242208.5
INHBA
inhibin subunit beta A
chr11_+_64234569 3.69 ENST00000309422.7
ENST00000426086.3
VEGFB
vascular endothelial growth factor B
chr1_-_9069797 3.64 ENST00000473209.1
SLC2A5
solute carrier family 2 member 5
chr5_-_83720813 3.63 ENST00000515590.1
ENST00000274341.9
HAPLN1
hyaluronan and proteoglycan link protein 1
chr18_+_58341038 3.60 ENST00000679791.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr7_+_22727147 3.47 ENST00000426291.5
ENST00000401651.5
ENST00000258743.10
ENST00000407492.5
ENST00000401630.7
ENST00000406575.1
IL6
interleukin 6
chr6_+_32844789 3.45 ENST00000414474.5
PSMB9
proteasome 20S subunit beta 9
chr4_-_25863537 3.41 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L3
SEL1L family member 3
chr5_-_83673544 3.40 ENST00000503117.1
ENST00000510978.5
HAPLN1
hyaluronan and proteoglycan link protein 1
chr18_-_28177016 3.15 ENST00000430882.6
CDH2
cadherin 2
chr19_-_39433703 2.95 ENST00000602153.5
RPS16
ribosomal protein S16
chr10_+_61901678 2.63 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr14_-_25010604 2.63 ENST00000550887.5
STXBP6
syntaxin binding protein 6
chr8_+_133191029 2.59 ENST00000250160.11
CCN4
cellular communication network factor 4
chr8_+_26577843 2.56 ENST00000311151.9
DPYSL2
dihydropyrimidinase like 2
chr9_+_12693327 2.41 ENST00000388918.10
TYRP1
tyrosinase related protein 1
chr1_-_159714581 2.30 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
CRP
C-reactive protein
chr15_+_67125707 2.27 ENST00000540846.6
SMAD3
SMAD family member 3
chrX_+_108439866 2.27 ENST00000361603.7
COL4A5
collagen type IV alpha 5 chain
chr8_+_103819244 2.04 ENST00000262231.14
ENST00000507740.5
ENST00000408894.6
RIMS2
regulating synaptic membrane exocytosis 2
chrX_-_134658450 1.98 ENST00000359237.9
PLAC1
placenta enriched 1
chr10_+_113854610 1.98 ENST00000369301.3
NHLRC2
NHL repeat containing 2
chr12_+_1691011 1.97 ENST00000357103.5
ADIPOR2
adiponectin receptor 2
chr5_+_149141817 1.92 ENST00000504238.5
ABLIM3
actin binding LIM protein family member 3
chr1_+_12464912 1.92 ENST00000543766.2
VPS13D
vacuolar protein sorting 13 homolog D
chr19_+_926001 1.91 ENST00000263620.8
ARID3A
AT-rich interaction domain 3A
chrX_+_108439779 1.84 ENST00000328300.11
COL4A5
collagen type IV alpha 5 chain
chr16_-_67944113 1.79 ENST00000264005.10
LCAT
lecithin-cholesterol acyltransferase
chr5_-_88785493 1.74 ENST00000503554.4
MEF2C
myocyte enhancer factor 2C
chr11_+_31650024 1.73 ENST00000638317.1
ELP4
elongator acetyltransferase complex subunit 4
chr3_+_173398438 1.56 ENST00000457714.5
NLGN1
neuroligin 1
chr5_-_88823763 1.45 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
MEF2C
myocyte enhancer factor 2C
chr18_-_48950960 1.41 ENST00000262158.8
SMAD7
SMAD family member 7
chr8_-_94436926 1.39 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr18_+_58196736 1.39 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr2_+_227813834 1.37 ENST00000358813.5
ENST00000409189.7
CCL20
C-C motif chemokine ligand 20
chr15_+_84981834 1.35 ENST00000394553.6
PDE8A
phosphodiesterase 8A
chr17_+_81395469 1.35 ENST00000584436.7
BAHCC1
BAH domain and coiled-coil containing 1
chr10_-_29736956 1.32 ENST00000674475.1
SVIL
supervillin
chr11_-_31807617 1.30 ENST00000639920.1
ENST00000640460.1
PAX6
paired box 6
chr17_+_59940908 1.26 ENST00000591035.1
ENSG00000267318.1
novel protein
chrX_-_108439472 1.24 ENST00000372216.8
COL4A6
collagen type IV alpha 6 chain
chr15_+_49423233 1.23 ENST00000560270.1
ENST00000267843.9
ENST00000560979.1
FGF7
fibroblast growth factor 7
chr7_-_27165517 1.17 ENST00000396345.1
ENST00000343483.7
HOXA9
homeobox A9
chr17_+_81395449 1.13 ENST00000675386.2
BAHCC1
BAH domain and coiled-coil containing 1
chr18_-_55351977 1.12 ENST00000643689.1
TCF4
transcription factor 4
chr17_-_81918134 1.04 ENST00000328666.11
SIRT7
sirtuin 7
chr4_+_143433491 1.02 ENST00000512843.1
GAB1
GRB2 associated binding protein 1
chr16_-_18896874 1.01 ENST00000565324.5
ENST00000561947.5
SMG1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
chr19_-_35742431 0.91 ENST00000592537.5
ENST00000246532.6
ENST00000588992.5
IGFLR1
IGF like family receptor 1
chr10_-_113854368 0.87 ENST00000369305.1
DCLRE1A
DNA cross-link repair 1A
chr6_+_46793379 0.87 ENST00000230588.9
ENST00000611727.2
MEP1A
meprin A subunit alpha
chr6_+_31715339 0.83 ENST00000375824.1
ENST00000375825.7
LY6G6D
lymphocyte antigen 6 family member G6D
chr2_+_210556590 0.80 ENST00000233072.10
ENST00000619804.1
CPS1
carbamoyl-phosphate synthase 1
chr1_-_9069572 0.77 ENST00000377414.7
SLC2A5
solute carrier family 2 member 5
chr12_-_27971970 0.70 ENST00000395872.5
ENST00000201015.8
PTHLH
parathyroid hormone like hormone
chr2_-_40512361 0.67 ENST00000403092.5
SLC8A1
solute carrier family 8 member A1
chr1_-_204166334 0.63 ENST00000272190.9
REN
renin
chr1_+_209686173 0.61 ENST00000615289.4
ENST00000367028.6
ENST00000261465.5
HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
chrX_-_106038721 0.52 ENST00000372563.2
SERPINA7
serpin family A member 7
chr2_+_190649062 0.50 ENST00000409581.5
ENST00000337386.10
NAB1
NGFI-A binding protein 1
chr6_+_15246054 0.49 ENST00000341776.7
JARID2
jumonji and AT-rich interaction domain containing 2
chr6_-_90586883 0.48 ENST00000369325.7
ENST00000369327.7
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr7_-_151519891 0.47 ENST00000262187.10
RHEB
Ras homolog, mTORC1 binding
chr7_-_81770039 0.43 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
HGF
hepatocyte growth factor
chr6_-_43053832 0.38 ENST00000265348.9
ENST00000674134.1
ENST00000674100.1
CUL7
cullin 7
chr16_-_15378294 0.37 ENST00000360151.9
ENST00000543801.5
NPIPA5
nuclear pore complex interacting protein family member A5
chr8_+_69466617 0.34 ENST00000525061.5
ENST00000260128.8
ENST00000458141.6
SULF1
sulfatase 1
chr3_-_165078480 0.33 ENST00000264382.8
SI
sucrase-isomaltase
chr20_-_57710539 0.33 ENST00000395816.7
ENST00000347215.8
PMEPA1
prostate transmembrane protein, androgen induced 1
chr7_-_81770122 0.31 ENST00000423064.7
HGF
hepatocyte growth factor
chr1_+_209704836 0.31 ENST00000367027.5
HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
chr2_-_40512423 0.30 ENST00000402441.5
ENST00000448531.1
SLC8A1
solute carrier family 8 member A1
chr7_+_142111739 0.29 ENST00000550469.6
ENST00000477922.3
MGAM2
maltase-glucoamylase 2 (putative)
chr16_+_14937443 0.28 ENST00000328085.10
NPIPA1
nuclear pore complex interacting protein family member A1
chr8_+_133191060 0.24 ENST00000519433.1
ENST00000517423.5
ENST00000220856.6
CCN4
cellular communication network factor 4
chr6_-_90587018 0.24 ENST00000369332.7
ENST00000369329.8
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr8_+_106726012 0.17 ENST00000449762.6
ENST00000297447.10
OXR1
oxidation resistance 1
chr17_+_7630094 0.14 ENST00000441599.6
ENST00000380450.9
ENST00000416273.7
ENST00000575903.5
ENST00000571153.5
ENST00000575618.5
ENST00000576152.1
ENST00000576830.5
SHBG
sex hormone binding globulin
chr17_+_7558296 0.11 ENST00000438470.5
ENST00000436057.5
TNFSF13
TNF superfamily member 13
chr21_-_42350987 0.08 ENST00000291526.5
TFF2
trefoil factor 2
chr12_-_23949642 0.07 ENST00000537393.5
ENST00000451604.7
ENST00000381381.6
SOX5
SRY-box transcription factor 5
chr4_+_159267737 0.05 ENST00000264431.8
RAPGEF2
Rap guanine nucleotide exchange factor 2
chr8_-_58500158 0.04 ENST00000301645.4
CYP7A1
cytochrome P450 family 7 subfamily A member 1
chr12_-_70754631 0.02 ENST00000440835.6
ENST00000549308.5
ENST00000550661.1
ENST00000378778.5
PTPRR
protein tyrosine phosphatase receptor type R
chrX_+_66164210 0.01 ENST00000343002.7
ENST00000336279.9
HEPH
hephaestin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 35.6 GO:2000542 negative regulation of gastrulation(GO:2000542)
5.3 16.0 GO:0035732 nitric oxide storage(GO:0035732)
4.5 8.9 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
2.3 9.0 GO:0001519 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
1.8 5.5 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
1.6 11.5 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
1.3 5.3 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
1.2 3.7 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.1 6.7 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.0 4.0 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
1.0 4.9 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.9 3.5 GO:0002384 hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
0.9 7.8 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.8 9.9 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.6 4.3 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431)
0.5 1.4 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.5 10.0 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.4 1.8 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.4 5.5 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.4 2.6 GO:0032445 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.4 3.7 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.4 5.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 3.2 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.4 1.6 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.4 2.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.4 8.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.3 1.0 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.3 9.7 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.3 1.2 GO:0060437 lung growth(GO:0060437)
0.3 3.0 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.3 1.4 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.3 4.1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.3 2.4 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.3 0.8 GO:0071400 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) cellular response to oleic acid(GO:0071400) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.3 2.6 GO:0051601 exocyst localization(GO:0051601)
0.2 2.0 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.2 2.0 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.2 11.6 GO:0031648 protein destabilization(GO:0031648)
0.2 2.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 6.4 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.2 2.3 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.2 18.3 GO:0070527 platelet aggregation(GO:0070527)
0.2 5.4 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.2 9.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.7 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 2.0 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.1 5.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 1.2 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.0 GO:0044557 relaxation of smooth muscle(GO:0044557)
0.1 0.6 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.1 3.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.9 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 1.3 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 2.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 9.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 2.6 GO:0016577 histone demethylation(GO:0016577)
0.1 0.5 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 2.6 GO:0030516 regulation of axon extension(GO:0030516)
0.0 4.4 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.3 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.0 0.7 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 1.0 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 4.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.9 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 8.6 GO:0030307 positive regulation of cell growth(GO:0030307)
0.0 0.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 3.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.8 GO:1905144 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 7.9 GO:0007018 microtubule-based movement(GO:0007018)
0.0 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 1.9 GO:1902400 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 1.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 2.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.7 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 9.0 GO:0006936 muscle contraction(GO:0006936)
0.0 0.5 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 5.4 GO:0030198 extracellular matrix organization(GO:0030198)
0.0 1.0 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.4 GO:0000281 mitotic cytokinesis(GO:0000281)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.9 35.6 GO:0005588 collagen type V trimer(GO:0005588)
4.0 16.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
3.0 8.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
2.8 14.0 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
1.6 24.1 GO:0030478 actin cap(GO:0030478)
1.2 3.7 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.9 5.4 GO:1990357 terminal web(GO:1990357)
0.7 3.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.7 5.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.6 6.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.5 4.3 GO:0070522 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.5 3.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 8.7 GO:0016342 catenin complex(GO:0016342)
0.4 4.1 GO:0061574 ASAP complex(GO:0061574)
0.3 2.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 10.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 2.5 GO:0005677 chromatin silencing complex(GO:0005677)
0.2 0.4 GO:1990393 3M complex(GO:1990393)
0.2 2.4 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 1.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 2.6 GO:0000145 exocyst(GO:0000145)
0.1 9.9 GO:0005771 multivesicular body(GO:0005771)
0.1 1.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 15.1 GO:0016459 myosin complex(GO:0016459)
0.1 1.6 GO:0032433 NMDA selective glutamate receptor complex(GO:0017146) filopodium tip(GO:0032433)
0.1 8.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 4.0 GO:1990391 DNA repair complex(GO:1990391)
0.1 5.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 6.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 26.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 5.5 GO:0043195 terminal bouton(GO:0043195)
0.1 9.0 GO:0043204 perikaryon(GO:0043204)
0.1 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 2.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 14.5 GO:0005769 early endosome(GO:0005769)
0.0 7.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.9 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 6.0 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.6 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 16.0 GO:0035730 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
2.9 11.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
2.3 9.0 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
1.6 6.3 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.5 8.9 GO:0031708 endothelin B receptor binding(GO:0031708)
1.1 5.5 GO:1990254 keratin filament binding(GO:1990254)
1.0 9.3 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
1.0 4.0 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.9 24.1 GO:0005523 tropomyosin binding(GO:0005523)
0.9 2.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.7 3.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.7 14.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.7 5.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.7 2.0 GO:0055100 adiponectin binding(GO:0055100)
0.6 2.3 GO:0033265 choline binding(GO:0033265)
0.6 57.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 9.9 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.5 4.3 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.5 3.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.5 1.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.4 2.6 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.4 3.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.4 7.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.4 2.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.3 1.0 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.3 0.9 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.3 1.8 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.3 6.7 GO:0031489 myosin V binding(GO:0031489)
0.2 1.0 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2 6.1 GO:0048156 tau protein binding(GO:0048156)
0.2 14.0 GO:0019003 GDP binding(GO:0019003)
0.2 7.6 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.7 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 7.9 GO:0019894 kinesin binding(GO:0019894)
0.1 2.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 3.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.8 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 0.3 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.1 0.3 GO:0004339 glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.1 0.9 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 3.1 GO:0032452 histone demethylase activity(GO:0032452)
0.1 7.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.1 GO:0030275 LRR domain binding(GO:0030275)
0.1 1.2 GO:0048185 activin binding(GO:0048185)
0.0 2.0 GO:0042056 chemoattractant activity(GO:0042056)
0.0 7.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 2.5 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 2.9 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 40.9 NABA COLLAGENS Genes encoding collagen proteins
0.2 9.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 23.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 3.7 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 3.5 ST STAT3 PATHWAY STAT3 Pathway
0.2 2.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 7.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.5 PID ALK1 PATHWAY ALK1 signaling events
0.1 10.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 8.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 8.9 PID ENDOTHELIN PATHWAY Endothelins
0.1 6.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 5.5 PID AURORA B PATHWAY Aurora B signaling
0.1 6.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 4.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 6.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 4.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 5.5 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 10.1 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 4.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 40.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.5 16.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 24.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 6.0 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.3 3.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.3 6.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 3.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 5.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 2.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 3.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 6.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 7.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 1.0 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.2 14.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 5.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 10.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 4.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 4.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 5.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 0.7 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 4.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 4.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 3.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 1.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 3.5 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 1.2 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 8.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.0 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 4.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production