ISMARA results: HOXC12

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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXC12_HOXD12

Z-value: 6.21

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Transcription factors associated with HOXC12_HOXD12

Gene Symbol	Gene ID	Gene Info
HOXC12 Ensembl NCBI GeneCards UniProt	ENSG00000123407.4	HOXC12
HOXD12 Ensembl NCBI GeneCards UniProt	ENSG00000170178.7	HOXD12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXD12	hg38_v1_chr2_+_176099787_176099812	-0.46	5.7e-13	Click!

Activity profile of HOXC12_HOXD12 motif

Sorted Z-values of HOXC12_HOXD12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC12_HOXD12

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr22_-_36528897 Show fit	32.98	ENST00000405442.5 ENST00000402116.2	EIF3D Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 3 subunit D
chr22_-_36529136 Show fit	29.74	ENST00000216190.13 ENST00000455547.5	EIF3D Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 3 subunit D
chr3_-_131502946 Show fit	27.14	ENST00000512877.1 ENST00000264995.8 ENST00000511168.5 ENST00000425847.6	MRPL3 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L3
chr1_-_220046432 Show fit	23.89	ENST00000609181.5 ENST00000366923.8	EPRS1 Ensembl NCBI GeneCards UniProt Show fit	glutamyl-prolyl-tRNA synthetase 1
chr2_+_171922442 Show fit	23.26	ENST00000264108.5	HAT1 Ensembl NCBI GeneCards UniProt Show fit	histone acetyltransferase 1
chr13_+_52455972 Show fit	21.57	ENST00000490903.5 ENST00000480747.1	CKAP2 Ensembl NCBI GeneCards UniProt Show fit	cytoskeleton associated protein 2
chr1_-_244862381 Show fit	21.45	ENST00000640001.1 ENST00000639628.1	HNRNPU Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein U
chr13_+_52455429 Show fit	20.33	ENST00000468284.1 ENST00000378034.7 ENST00000378037.9 ENST00000258607.10	CKAP2 Ensembl NCBI GeneCards UniProt Show fit	cytoskeleton associated protein 2
chr1_-_246507237 Show fit	19.30	ENST00000490107.6	SMYD3 Ensembl NCBI GeneCards UniProt Show fit	SET and MYND domain containing 3
chr7_+_65373839 Show fit	17.99	ENST00000431504.1 ENST00000328747.12	ZNF92 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 92
chr7_+_65373873 Show fit	17.63	ENST00000450302.2	ZNF92 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 92
chr7_+_65373799 Show fit	16.79	ENST00000357512.3	ZNF92 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 92
chr2_-_224497816 Show fit	16.64	ENST00000451538.1	CUL3 Ensembl NCBI GeneCards UniProt Show fit	cullin 3
chr5_-_181243370 Show fit	16.24	ENST00000502844.5	RACK1 Ensembl NCBI GeneCards UniProt Show fit	receptor for activated C kinase 1
chr12_+_6494087 Show fit	15.74	ENST00000382457.8 ENST00000315579.10	NCAPD2 Ensembl NCBI GeneCards UniProt Show fit	non-SMC condensin I complex subunit D2
chr1_-_156338226 Show fit	13.96	ENST00000496684.6 ENST00000368259.6 ENST00000472765.6 ENST00000295688.8 ENST00000533194.5 ENST00000478640.6	CCT3 Ensembl NCBI GeneCards UniProt Show fit	chaperonin containing TCP1 subunit 3
chr6_-_8102481 Show fit	13.34	ENST00000502429.5 ENST00000429723.6 ENST00000379715.10 ENST00000507463.1	EEF1E1 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation elongation factor 1 epsilon 1
chr11_+_112025367 Show fit	12.87	ENST00000679614.1 ENST00000679878.1 ENST00000280346.11 ENST00000681339.1 ENST00000681328.1 ENST00000681316.1 ENST00000531306.2 ENST00000680331.1 ENST00000393051.5	DLAT Ensembl NCBI GeneCards UniProt Show fit	dihydrolipoamide S-acetyltransferase
chr15_+_66505289 Show fit	12.36	ENST00000565627.5 ENST00000564179.5 ENST00000307897.10	ZWILCH Ensembl NCBI GeneCards UniProt Show fit	zwilch kinetochore protein
chr1_-_85708382 Show fit	12.30	ENST00000370574.4 ENST00000431532.6	ZNHIT6 Ensembl NCBI GeneCards UniProt Show fit	zinc finger HIT-type containing 6
chr10_+_123154414 Show fit	12.16	ENST00000368858.9	BUB3 Ensembl NCBI GeneCards UniProt Show fit	BUB3 mitotic checkpoint protein
chr15_+_66504959 Show fit	11.58	ENST00000535141.6 ENST00000613446.4 ENST00000446801.6	ZWILCH Ensembl NCBI GeneCards UniProt Show fit	zwilch kinetochore protein
chr8_-_143617498 Show fit	11.48	ENST00000425753.7	GFUS Ensembl NCBI GeneCards UniProt Show fit	GDP-L-fucose synthase
chr19_+_21082224 Show fit	11.42	ENST00000620627.1	ZNF714 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 714
chr5_+_169583636 Show fit	11.22	ENST00000506574.5 ENST00000515224.5 ENST00000629457.2 ENST00000508247.5 ENST00000265295.9 ENST00000513941.5	SPDL1 Ensembl NCBI GeneCards UniProt Show fit	spindle apparatus coiled-coil protein 1
chr12_+_69239592 Show fit	11.17	ENST00000456847.7 ENST00000266679.8	CPSF6 Ensembl NCBI GeneCards UniProt Show fit	cleavage and polyadenylation specific factor 6
chr1_-_154608705 Show fit	11.00	ENST00000649749.1 ENST00000648871.1	ADAR Ensembl NCBI GeneCards UniProt Show fit	adenosine deaminase RNA specific
chr7_+_138460238 Show fit	10.99	ENST00000343526.9	TRIM24 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 24
chr13_+_33818122 Show fit	10.95	ENST00000380071.8	RFC3 Ensembl NCBI GeneCards UniProt Show fit	replication factor C subunit 3
chr3_-_25664877 Show fit	10.71	ENST00000264331.9 ENST00000424225.1	TOP2B Ensembl NCBI GeneCards UniProt Show fit	DNA topoisomerase II beta
chr18_-_812516 Show fit	10.70	ENST00000584307.5	YES1 Ensembl NCBI GeneCards UniProt Show fit	YES proto-oncogene 1, Src family tyrosine kinase
chr1_+_149477960 Show fit	10.67	ENST00000369227.7	NBPF19 Ensembl NCBI GeneCards UniProt Show fit	NBPF member 19
chr18_+_12703003 Show fit	10.57	ENST00000590217.5 ENST00000317615.11	PSMG2 Ensembl NCBI GeneCards UniProt Show fit	proteasome assembly chaperone 2
chr5_+_154941063 Show fit	10.55	ENST00000523037.6 ENST00000265229.12 ENST00000439747.7 ENST00000522038.5	MRPL22 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein L22
chr6_+_34757473 Show fit	10.48	ENST00000244520.10 ENST00000374018.5 ENST00000374017.3	SNRPC Ensembl NCBI GeneCards UniProt Show fit	small nuclear ribonucleoprotein polypeptide C
chr1_+_159005953 Show fit	10.22	ENST00000426592.6	IFI16 Ensembl NCBI GeneCards UniProt Show fit	interferon gamma inducible protein 16
chr18_+_9103959 Show fit	10.06	ENST00000400033.1	NDUFV2 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase core subunit V2
chr8_-_143617457 Show fit	9.84	ENST00000529048.5 ENST00000529064.5	GFUS Ensembl NCBI GeneCards UniProt Show fit	GDP-L-fucose synthase
chr11_+_35139162 Show fit	9.81	ENST00000415148.6 ENST00000263398.11 ENST00000428726.8 ENST00000526669.6 ENST00000433892.6 ENST00000525211.6 ENST00000278386.10 ENST00000434472.6 ENST00000352818.8 ENST00000442151.6	CD44 Ensembl NCBI GeneCards UniProt Show fit	CD44 molecule (Indian blood group)
chr12_+_104215772 Show fit	9.66	ENST00000429002.6 ENST00000525566.6	TXNRD1 Ensembl NCBI GeneCards UniProt Show fit	thioredoxin reductase 1
chr5_-_177006581 Show fit	9.39	ENST00000506128.5	UIMC1 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin interaction motif containing 1
chr10_-_73096974 Show fit	8.98	ENST00000440381.5 ENST00000263556.3	P4HA1 Ensembl NCBI GeneCards UniProt Show fit	prolyl 4-hydroxylase subunit alpha 1
chr10_+_123154364 Show fit	8.96	ENST00000368859.6 ENST00000368865.9	BUB3 Ensembl NCBI GeneCards UniProt Show fit	BUB3 mitotic checkpoint protein
chr4_-_82844418 Show fit	8.88	ENST00000503937.5	SEC31A Ensembl NCBI GeneCards UniProt Show fit	SEC31 homolog A, COPII coat complex component
chr12_+_32679269 Show fit	8.83	ENST00000358214.9 ENST00000553257.6 ENST00000549701.6 ENST00000266481.10 ENST00000551476.5 ENST00000550154.5 ENST00000547312.5 ENST00000381000.8 ENST00000548750.5	DNM1L Ensembl NCBI GeneCards UniProt Show fit	dynamin 1 like
chr6_-_36547400 Show fit	8.79	ENST00000229812.8	STK38 Ensembl NCBI GeneCards UniProt Show fit	serine/threonine kinase 38
chr4_-_102868869 Show fit	8.48	ENST00000338145.7 ENST00000357194.10	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr4_-_39366342 Show fit	8.39	ENST00000503784.1 ENST00000349703.7 ENST00000381897.5	RFC1 Ensembl NCBI GeneCards UniProt Show fit	replication factor C subunit 1
chr11_-_107858777 Show fit	8.33	ENST00000525815.6	SLC35F2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 35 member F2
chr12_+_32679200 Show fit	8.32	ENST00000452533.6 ENST00000414834.6	DNM1L Ensembl NCBI GeneCards UniProt Show fit	dynamin 1 like
chr11_+_126327863 Show fit	8.29	ENST00000648516.1	DCPS Ensembl NCBI GeneCards UniProt Show fit	decapping enzyme, scavenger
chr1_-_63523175 Show fit	8.16	ENST00000371092.7 ENST00000271002.15	ITGB3BP Ensembl NCBI GeneCards UniProt Show fit	integrin subunit beta 3 binding protein
chr6_+_30328889 Show fit	8.14	ENST00000396547.5 ENST00000623385.3	TRIM39 Ensembl NCBI GeneCards UniProt Show fit TRIM39-RPP21 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 39 TRIM39-RPP21 readthrough
chr17_+_47209375 Show fit	8.07	ENST00000572303.1	MYL4 Ensembl NCBI GeneCards UniProt Show fit	myosin light chain 4
chr1_-_165768835 Show fit	7.99	ENST00000481278.5	TMCO1 Ensembl NCBI GeneCards UniProt Show fit	transmembrane and coiled-coil domains 1
chr17_+_58692563 Show fit	7.92	ENST00000461271.5 ENST00000583539.5 ENST00000337432.9 ENST00000421782.3	RAD51C Ensembl NCBI GeneCards UniProt Show fit	RAD51 paralog C
chr7_+_150368189 Show fit	7.80	ENST00000519397.1 ENST00000479668.5	REPIN1 Ensembl NCBI GeneCards UniProt Show fit	replication initiator 1
chr3_-_25783381 Show fit	7.70	ENST00000308710.9 ENST00000676225.1	NGLY1 Ensembl NCBI GeneCards UniProt Show fit	N-glycanase 1
chr14_-_35121950 Show fit	7.50	ENST00000554361.5 ENST00000261475.10	PPP2R3C Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2 regulatory subunit B''gamma
chr7_-_128409973 Show fit	7.43	ENST00000338791.11 ENST00000354269.9 ENST00000348127.10 ENST00000497868.5	IMPDH1 Ensembl NCBI GeneCards UniProt Show fit	inosine monophosphate dehydrogenase 1
chr4_-_83284752 Show fit	7.37	ENST00000311461.7 ENST00000647002.2 ENST00000311469.9	COQ2 Ensembl NCBI GeneCards UniProt Show fit	coenzyme Q2, polyprenyltransferase
chr19_+_48993864 Show fit	7.28	ENST00000595090.6	RUVBL2 Ensembl NCBI GeneCards UniProt Show fit	RuvB like AAA ATPase 2
chr2_+_200889327 Show fit	7.27	ENST00000426253.5 ENST00000454952.1 ENST00000651500.1 ENST00000409020.6 ENST00000359683.8	NIF3L1 Ensembl NCBI GeneCards UniProt Show fit	NGG1 interacting factor 3 like 1
chr1_-_68497030 Show fit	7.27	ENST00000456315.7 ENST00000525124.1 ENST00000370966.9	DEPDC1 Ensembl NCBI GeneCards UniProt Show fit	DEP domain containing 1
chr15_-_66504832 Show fit	7.10	ENST00000569438.2 ENST00000569696.5 ENST00000307961.11	RPL4 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L4
chr2_+_27212866 Show fit	7.05	ENST00000419744.1	ATRAID Ensembl NCBI GeneCards UniProt Show fit	all-trans retinoic acid induced differentiation factor
chr16_-_88811897 Show fit	7.04	ENST00000569616.1 ENST00000563655.5 ENST00000567713.5 ENST00000426324.6 ENST00000378364.8	APRT Ensembl NCBI GeneCards UniProt Show fit	adenine phosphoribosyltransferase
chr12_-_46372763 Show fit	6.83	ENST00000256689.10	SLC38A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 38 member 2
chr19_-_46846138 Show fit	6.67	ENST00000597020.5	AP2S1 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 2 subunit sigma 1
chr2_+_27212320 Show fit	6.59	ENST00000405489.7	ATRAID Ensembl NCBI GeneCards UniProt Show fit	all-trans retinoic acid induced differentiation factor
chr16_+_396713 Show fit	6.58	ENST00000397722.5	NME4 Ensembl NCBI GeneCards UniProt Show fit	NME/NM23 nucleoside diphosphate kinase 4
chr10_+_49942048 Show fit	6.56	ENST00000651259.3 ENST00000652716.1	TIMM23B Ensembl NCBI GeneCards UniProt Show fit	translocase of inner mitochondrial membrane 23 homolog B
chr10_-_73096850 Show fit	6.52	ENST00000307116.6 ENST00000373008.6 ENST00000394890.7	P4HA1 Ensembl NCBI GeneCards UniProt Show fit	prolyl 4-hydroxylase subunit alpha 1
chr16_-_85799503 Show fit	6.50	ENST00000253457.8	EMC8 Ensembl NCBI GeneCards UniProt Show fit	ER membrane protein complex subunit 8
chr9_+_131190119 Show fit	6.50	ENST00000483497.6	NUP214 Ensembl NCBI GeneCards UniProt Show fit	nucleoporin 214
chr6_+_63571702 Show fit	6.48	ENST00000672924.1	PTP4A1 Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase 4A1
chr1_+_158930778 Show fit	6.42	ENST00000458222.5	PYHIN1 Ensembl NCBI GeneCards UniProt Show fit	pyrin and HIN domain family member 1
chr2_+_200889411 Show fit	6.38	ENST00000409357.5 ENST00000409129.2	NIF3L1 Ensembl NCBI GeneCards UniProt Show fit	NGG1 interacting factor 3 like 1
chr2_+_73828916 Show fit	6.32	ENST00000339566.7 ENST00000683349.1 ENST00000682157.1 ENST00000682851.1 ENST00000394070.7 ENST00000409707.6 ENST00000684585.1 ENST00000683434.1 ENST00000682352.1 ENST00000424659.6 ENST00000536064.2 ENST00000684355.1 ENST00000682998.1 ENST00000682799.1 ENST00000394073.6 ENST00000682848.1 ENST00000683877.1 ENST00000682351.1 ENST00000683818.1 ENST00000683391.1 ENST00000682558.1	STAMBP Ensembl NCBI GeneCards UniProt Show fit	STAM binding protein
chr10_+_45972482 Show fit	6.17	ENST00000580018.4	TIMM23 Ensembl NCBI GeneCards UniProt Show fit	translocase of inner mitochondrial membrane 23
chr4_+_87422800 Show fit	6.16	ENST00000440591.6	NUDT9 Ensembl NCBI GeneCards UniProt Show fit	nudix hydrolase 9
chr16_-_18896874 Show fit	6.13	ENST00000565324.5 ENST00000561947.5	SMG1 Ensembl NCBI GeneCards UniProt Show fit	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
chr19_+_48993525 Show fit	6.09	ENST00000601968.5 ENST00000596837.5	RUVBL2 Ensembl NCBI GeneCards UniProt Show fit	RuvB like AAA ATPase 2
chr2_+_86907953 Show fit	5.90	ENST00000409776.6	RGPD1 Ensembl NCBI GeneCards UniProt Show fit	RANBP2 like and GRIP domain containing 1
chr16_+_397209 Show fit	5.83	ENST00000382940.8	NME4 Ensembl NCBI GeneCards UniProt Show fit	NME/NM23 nucleoside diphosphate kinase 4
chr1_+_146959859 Show fit	5.73	ENST00000617614.4 ENST00000439206.6 ENST00000617864.3 ENST00000613714.2 ENST00000579935.8	NBPF12 Ensembl NCBI GeneCards UniProt Show fit	NBPF member 12
chr7_-_41703062 Show fit	5.65	ENST00000242208.5	INHBA Ensembl NCBI GeneCards UniProt Show fit	inhibin subunit beta A
chr2_+_161136901 Show fit	5.54	ENST00000259075.6 ENST00000432002.5	TANK Ensembl NCBI GeneCards UniProt Show fit	TRAF family member associated NFKB activator
chr4_+_121801311 Show fit	5.45	ENST00000379663.7 ENST00000243498.10 ENST00000509800.5	EXOSC9 Ensembl NCBI GeneCards UniProt Show fit	exosome component 9
chr7_-_27180230 Show fit	5.45	ENST00000396344.4	HOXA10 Ensembl NCBI GeneCards UniProt Show fit	homeobox A10
chr14_+_23306958 Show fit	5.41	ENST00000554635.1 ENST00000557008.2	BCL2L2 Ensembl NCBI GeneCards UniProt Show fit BCL2L2-PABPN1 Ensembl NCBI GeneCards UniProt Show fit	BCL2 like 2 BCL2L2-PABPN1 readthrough
chr11_+_67606894 Show fit	5.36	ENST00000532303.5 ENST00000532244.5 ENST00000528328.1 ENST00000322776.11 ENST00000529927.5 ENST00000532343.5 ENST00000415352.6 ENST00000533075.5 ENST00000529867.5 ENST00000530638.1	NDUFV1 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase core subunit V1
chr4_-_73223082 Show fit	5.32	ENST00000509867.6	ANKRD17 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat domain 17
chr11_-_18526885 Show fit	5.30	ENST00000251968.4 ENST00000536719.5	TSG101 Ensembl NCBI GeneCards UniProt Show fit	tumor susceptibility 101
chr7_-_106112525 Show fit	5.18	ENST00000011473.6	SYPL1 Ensembl NCBI GeneCards UniProt Show fit	synaptophysin like 1
chr19_+_7348930 Show fit	5.07	ENST00000668164.2	ARHGEF18 Ensembl NCBI GeneCards UniProt Show fit	Rho/Rac guanine nucleotide exchange factor 18
chr17_+_18856299 Show fit	5.07	ENST00000432893.6 ENST00000610773.4 ENST00000414602.5 ENST00000574522.5 ENST00000570450.5 ENST00000419071.6	PRPSAP2 Ensembl NCBI GeneCards UniProt Show fit	phosphoribosyl pyrophosphate synthetase associated protein 2
chr7_-_128409901 Show fit	5.05	ENST00000419067.6	IMPDH1 Ensembl NCBI GeneCards UniProt Show fit	inosine monophosphate dehydrogenase 1
chr5_-_177006692 Show fit	5.00	ENST00000507513.1 ENST00000511320.6	UIMC1 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin interaction motif containing 1
chr19_-_23758877 Show fit	4.96	ENST00000402377.3	ZNF681 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 681
chr17_+_47651061 Show fit	4.96	ENST00000540627.5	KPNB1 Ensembl NCBI GeneCards UniProt Show fit	karyopherin subunit beta 1
chr12_-_14961559 Show fit	4.96	ENST00000228945.9 ENST00000541546.5	ARHGDIB Ensembl NCBI GeneCards UniProt Show fit	Rho GDP dissociation inhibitor beta
chr17_-_59707404 Show fit	4.89	ENST00000393038.3	PTRH2 Ensembl NCBI GeneCards UniProt Show fit	peptidyl-tRNA hydrolase 2
chr1_+_35931076 Show fit	4.89	ENST00000397828.3 ENST00000373191.9	AGO3 Ensembl NCBI GeneCards UniProt Show fit	argonaute RISC catalytic component 3
chr14_-_49852760 Show fit	4.88	ENST00000555970.5 ENST00000298310.10 ENST00000554626.5 ENST00000556672.1	NEMF Ensembl NCBI GeneCards UniProt Show fit	nuclear export mediator factor
chr12_+_67269328 Show fit	4.85	ENST00000545606.6	CAND1 Ensembl NCBI GeneCards UniProt Show fit	cullin associated and neddylation dissociated 1
chr15_-_34039042 Show fit	4.83	ENST00000306730.8	AVEN Ensembl NCBI GeneCards UniProt Show fit	apoptosis and caspase activation inhibitor
chr5_-_176388563 Show fit	4.83	ENST00000509257.1 ENST00000616685.1 ENST00000614830.5	NOP16 Ensembl NCBI GeneCards UniProt Show fit	NOP16 nucleolar protein
chr6_+_10694916 Show fit	4.81	ENST00000379568.4	PAK1IP1 Ensembl NCBI GeneCards UniProt Show fit	PAK1 interacting protein 1
chr8_-_13276491 Show fit	4.76	ENST00000512044.6	DLC1 Ensembl NCBI GeneCards UniProt Show fit	DLC1 Rho GTPase activating protein
chr1_-_169711603 Show fit	4.68	ENST00000236147.6 ENST00000650983.1	SELL Ensembl NCBI GeneCards UniProt Show fit	selectin L
chr6_+_32844789 Show fit	4.62	ENST00000414474.5	PSMB9 Ensembl NCBI GeneCards UniProt Show fit	proteasome 20S subunit beta 9
chr14_+_73167829 Show fit	4.56	ENST00000406768.1	PSEN1 Ensembl NCBI GeneCards UniProt Show fit	presenilin 1
chr6_-_31714062 Show fit	4.51	ENST00000409239.5	LY6G6E Ensembl NCBI GeneCards UniProt Show fit	lymphocyte antigen 6 family member G6E
chr19_-_45424364 Show fit	4.51	ENST00000589165.5	ERCC1 Ensembl NCBI GeneCards UniProt Show fit	ERCC excision repair 1, endonuclease non-catalytic subunit
chr19_+_13774438 Show fit	4.31	ENST00000588234.6 ENST00000221576.4	C19orf53 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 53
chr16_+_8642375 Show fit	4.30	ENST00000562973.1	METTL22 Ensembl NCBI GeneCards UniProt Show fit	methyltransferase like 22
chr9_-_5437908 Show fit	4.21	ENST00000223864.7	PLGRKT Ensembl NCBI GeneCards UniProt Show fit	plasminogen receptor with a C-terminal lysine
chr5_-_90409720 Show fit	4.20	ENST00000522864.5 ENST00000283122.8 ENST00000522083.5 ENST00000522565.5 ENST00000522842.1	CETN3 Ensembl NCBI GeneCards UniProt Show fit	centrin 3
chrX_-_119791620 Show fit	4.16	ENST00000361575.4	RPL39 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L39
chr8_-_33513077 Show fit	4.13	ENST00000360742.9 ENST00000523305.1 ENST00000431156.7 ENST00000613904.1	TTI2 Ensembl NCBI GeneCards UniProt Show fit	TELO2 interacting protein 2
chr2_-_85418421 Show fit	4.12	ENST00000409275.1	CAPG Ensembl NCBI GeneCards UniProt Show fit	capping actin protein, gelsolin like
chr6_+_30571393 Show fit	4.09	ENST00000376545.7 ENST00000441867.6 ENST00000468958.1 ENST00000326195.13	ABCF1 Ensembl NCBI GeneCards UniProt Show fit	ATP binding cassette subfamily F member 1
chr14_+_24232892 Show fit	4.04	ENST00000420554.6	GMPR2 Ensembl NCBI GeneCards UniProt Show fit	guanosine monophosphate reductase 2
chr2_+_27211992 Show fit	4.03	ENST00000380171.8 ENST00000611786.4	ATRAID Ensembl NCBI GeneCards UniProt Show fit	all-trans retinoic acid induced differentiation factor
chr6_-_89352706 Show fit	4.01	ENST00000435041.3	UBE2J1 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 J1
chr6_-_131000722 Show fit	4.00	ENST00000528282.5	EPB41L2 Ensembl NCBI GeneCards UniProt Show fit	erythrocyte membrane protein band 4.1 like 2
chr1_+_147242654 Show fit	3.99	ENST00000652587.1 ENST00000361293.10 ENST00000369258.8 ENST00000369259.4 ENST00000650714.1 ENST00000639534.1	CHD1L Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 1 like
chr19_+_2785481 Show fit	3.98	ENST00000307741.11 ENST00000585338.1	THOP1 Ensembl NCBI GeneCards UniProt Show fit	thimet oligopeptidase 1
chr3_+_179604785 Show fit	3.95	ENST00000611971.4 ENST00000493866.5 ENST00000259037.8 ENST00000472629.5 ENST00000482604.5	NDUFB5 Ensembl NCBI GeneCards UniProt Show fit	NADH:ubiquinone oxidoreductase subunit B5
chr19_+_21082140 Show fit	3.94	ENST00000616183.1 ENST00000596053.5	ZNF714 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 714
chr15_+_76931704 Show fit	3.93	ENST00000320963.9 ENST00000394885.8 ENST00000394883.3	RCN2 Ensembl NCBI GeneCards UniProt Show fit	reticulocalbin 2
chr1_-_165768848 Show fit	3.83	ENST00000367881.11 ENST00000464650.5 ENST00000612311.4 ENST00000628579.1	TMCO1 Ensembl NCBI GeneCards UniProt Show fit	transmembrane and coiled-coil domains 1
chr3_-_197184131 Show fit	3.73	ENST00000452595.5	DLG1 Ensembl NCBI GeneCards UniProt Show fit	discs large MAGUK scaffold protein 1
chr2_-_136118142 Show fit	3.72	ENST00000241393.4	CXCR4 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine receptor 4
chr17_+_68525795 Show fit	3.72	ENST00000592800.5	PRKAR1A Ensembl NCBI GeneCards UniProt Show fit	protein kinase cAMP-dependent type I regulatory subunit alpha
chr12_-_30735014 Show fit	3.56	ENST00000433722.6	CAPRIN2 Ensembl NCBI GeneCards UniProt Show fit	caprin family member 2
chr3_-_172523460 Show fit	3.56	ENST00000420541.6	TNFSF10 Ensembl NCBI GeneCards UniProt Show fit	TNF superfamily member 10
chr7_+_138460400 Show fit	3.51	ENST00000415680.6	TRIM24 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 24
chr1_+_239386556 Show fit	3.48	ENST00000676153.1	CHRM3 Ensembl NCBI GeneCards UniProt Show fit	cholinergic receptor muscarinic 3
chr10_-_96271553 Show fit	3.47	ENST00000224337.10	BLNK Ensembl NCBI GeneCards UniProt Show fit	B cell linker
chr1_-_23559490 Show fit	3.40	ENST00000374561.6	ID3 Ensembl NCBI GeneCards UniProt Show fit	inhibitor of DNA binding 3, HLH protein
chr12_-_14803462 Show fit	3.36	ENST00000261167.7 ENST00000535328.1	WBP11 Ensembl NCBI GeneCards UniProt Show fit	WW domain binding protein 11
chr12_+_4649097 Show fit	3.31	ENST00000648836.1 ENST00000266544.10	ENSG00000255639.3 Ensembl NCBI GeneCards UniProt Show fit NDUFA9 Ensembl NCBI GeneCards UniProt Show fit	novel protein NADH:ubiquinone oxidoreductase subunit A9
chr11_-_64778747 Show fit	3.30	ENST00000227503.13 ENST00000377394.7 ENST00000334944.9	SF1 Ensembl NCBI GeneCards UniProt Show fit	splicing factor 1
chr11_-_67508091 Show fit	3.26	ENST00000531506.1	CDK2AP2 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase 2 associated protein 2
chr4_+_47485268 Show fit	3.24	ENST00000273859.8 ENST00000504445.1	ATP10D Ensembl NCBI GeneCards UniProt Show fit	ATPase phospholipid transporting 10D (putative)
chr16_+_396743 Show fit	3.17	ENST00000454619.5	NME4 Ensembl NCBI GeneCards UniProt Show fit	NME/NM23 nucleoside diphosphate kinase 4
chr2_-_136116165 Show fit	3.15	ENST00000409817.1	CXCR4 Ensembl NCBI GeneCards UniProt Show fit	C-X-C motif chemokine receptor 4
chr4_-_110198650 Show fit	3.14	ENST00000394607.7	ELOVL6 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 6
chr16_+_67873036 Show fit	3.07	ENST00000358933.10	EDC4 Ensembl NCBI GeneCards UniProt Show fit	enhancer of mRNA decapping 4
chr3_-_165837412 Show fit	2.92	ENST00000479451.5 ENST00000488954.1 ENST00000264381.8	BCHE Ensembl NCBI GeneCards UniProt Show fit	butyrylcholinesterase
chr11_-_102798148 Show fit	2.86	ENST00000315274.7	MMP1 Ensembl NCBI GeneCards UniProt Show fit	matrix metallopeptidase 1
chr13_-_40771105 Show fit	2.86	ENST00000323563.8	MRPS31 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein S31
chr15_+_78149354 Show fit	2.84	ENST00000558554.5 ENST00000557826.5 ENST00000561279.5 ENST00000299518.7 ENST00000559186.5 ENST00000560770.5 ENST00000559881.5 ENST00000559205.1 ENST00000629769.2	IDH3A Ensembl NCBI GeneCards UniProt Show fit	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha
chr1_-_53220589 Show fit	2.81	ENST00000294360.5	CZIB Ensembl NCBI GeneCards UniProt Show fit	CXXC motif containing zinc binding protein
chr1_+_192575765 Show fit	2.73	ENST00000469578.2 ENST00000367459.8	RGS1 Ensembl NCBI GeneCards UniProt Show fit	regulator of G protein signaling 1
chr12_-_71157872 Show fit	2.72	ENST00000546561.2	TSPAN8 Ensembl NCBI GeneCards UniProt Show fit	tetraspanin 8
chr8_+_7730739 Show fit	2.66	ENST00000648174.1	FAM90A16P Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 90 member A16, pseudogene
chr14_+_24232612 Show fit	2.63	ENST00000560139.5 ENST00000559910.5 ENST00000348719.11	GMPR2 Ensembl NCBI GeneCards UniProt Show fit	guanosine monophosphate reductase 2
chr11_-_9314564 Show fit	2.62	ENST00000611268.4 ENST00000528080.6 ENST00000527813.5 ENST00000533723.1	TMEM41B Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 41B
chr14_+_24232921 Show fit	2.58	ENST00000557854.5 ENST00000399440.7 ENST00000559104.5 ENST00000456667.7	GMPR2 Ensembl NCBI GeneCards UniProt Show fit	guanosine monophosphate reductase 2
chr6_-_106325616 Show fit	2.56	ENST00000360666.6	ATG5 Ensembl NCBI GeneCards UniProt Show fit	autophagy related 5
chr21_-_14546297 Show fit	2.52	ENST00000400566.6 ENST00000400564.5	SAMSN1 Ensembl NCBI GeneCards UniProt Show fit	SAM domain, SH3 domain and nuclear localization signals 1
chr16_+_10743786 Show fit	2.48	ENST00000574334.5 ENST00000283027.10 ENST00000433392.6	NUBP1 Ensembl NCBI GeneCards UniProt Show fit	nucleotide binding protein 1
chr10_+_5048748 Show fit	2.45	ENST00000602997.5 ENST00000439082.7	AKR1C3 Ensembl NCBI GeneCards UniProt Show fit	aldo-keto reductase family 1 member C3
chrX_-_134658450 Show fit	2.41	ENST00000359237.9	PLAC1 Ensembl NCBI GeneCards UniProt Show fit	placenta enriched 1
chr6_-_73523757 Show fit	2.38	ENST00000455918.2 ENST00000677236.1	EEF1A1 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation elongation factor 1 alpha 1
chr6_-_34888004 Show fit	2.35	ENST00000650109.1 ENST00000361288.9 ENST00000420584.3	TAF11 Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor 11
chr3_+_100709382 Show fit	2.32	ENST00000620299.5	TFG Ensembl NCBI GeneCards UniProt Show fit	trafficking from ER to golgi regulator
chr1_-_101025763 Show fit	2.28	ENST00000342173.11 ENST00000488176.1 ENST00000370109.8	DPH5 Ensembl NCBI GeneCards UniProt Show fit	diphthamide biosynthesis 5
chr19_-_48993300 Show fit	2.28	ENST00000323798.8 ENST00000263276.6	GYS1 Ensembl NCBI GeneCards UniProt Show fit	glycogen synthase 1
chr7_-_134459089 Show fit	2.24	ENST00000285930.9	AKR1B1 Ensembl NCBI GeneCards UniProt Show fit	aldo-keto reductase family 1 member B
chr11_-_33717409 Show fit	2.23	ENST00000651485.1	CD59 Ensembl NCBI GeneCards UniProt Show fit	CD59 molecule (CD59 blood group)
chr11_-_796185 Show fit	2.22	ENST00000533385.5 ENST00000528936.5 ENST00000629634.2 ENST00000625752.2 ENST00000528606.5 ENST00000320230.9	SLC25A22 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 25 member 22
chr2_-_229921316 Show fit	2.20	ENST00000428959.5 ENST00000675423.1	TRIP12 Ensembl NCBI GeneCards UniProt Show fit	thyroid hormone receptor interactor 12
chr3_+_112990956 Show fit	2.16	ENST00000383678.8 ENST00000383677.7 ENST00000619116.4	GTPBP8 Ensembl NCBI GeneCards UniProt Show fit	GTP binding protein 8 (putative)
chr12_-_71157992 Show fit	2.16	ENST00000247829.8	TSPAN8 Ensembl NCBI GeneCards UniProt Show fit	tetraspanin 8
chr6_+_13272709 Show fit	2.15	ENST00000379335.8	PHACTR1 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 1
chr13_-_78659124 Show fit	2.12	ENST00000282003.7	OBI1 Ensembl NCBI GeneCards UniProt Show fit	ORC ubiquitin ligase 1
chr2_+_137964279 Show fit	2.09	ENST00000329366.8	HNMT Ensembl NCBI GeneCards UniProt Show fit	histamine N-methyltransferase
chrX_+_11760087 Show fit	2.06	ENST00000649271.1	MSL3 Ensembl NCBI GeneCards UniProt Show fit	MSL complex subunit 3
chr7_+_74650224 Show fit	2.06	ENST00000652150.1 ENST00000650807.1	GTF2I Ensembl NCBI GeneCards UniProt Show fit	general transcription factor IIi
chr4_-_110198579 Show fit	2.03	ENST00000302274.8	ELOVL6 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 6
chr3_-_172523423 Show fit	2.03	ENST00000241261.7	TNFSF10 Ensembl NCBI GeneCards UniProt Show fit	TNF superfamily member 10
chr14_+_24232422 Show fit	2.01	ENST00000620807.4 ENST00000355299.8 ENST00000559836.5	GMPR2 Ensembl NCBI GeneCards UniProt Show fit	guanosine monophosphate reductase 2
chr14_-_24232332 Show fit	1.99	ENST00000534348.5 ENST00000524927.1 ENST00000250495.10	NEDD8-MDP1 Ensembl NCBI GeneCards UniProt Show fit NEDD8 Ensembl NCBI GeneCards UniProt Show fit	NEDD8-MDP1 readthrough NEDD8 ubiquitin like modifier
chr14_+_89955895 Show fit	1.99	ENST00000393452.7 ENST00000554180.5 ENST00000335725.9 ENST00000393454.6 ENST00000553617.5 ENST00000556867.1 ENST00000553527.1	TDP1 Ensembl NCBI GeneCards UniProt Show fit	tyrosyl-DNA phosphodiesterase 1
chr8_-_42207667 Show fit	1.97	ENST00000352041.7 ENST00000679151.1 ENST00000679300.1	PLAT Ensembl NCBI GeneCards UniProt Show fit	plasminogen activator, tissue type
chr19_+_21142024 Show fit	1.94	ENST00000600692.5 ENST00000599296.5 ENST00000594425.5 ENST00000311048.11	ZNF431 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 431
chr1_+_23791138 Show fit	1.92	ENST00000374514.8 ENST00000420982.5 ENST00000374505.6	LYPLA2 Ensembl NCBI GeneCards UniProt Show fit	lysophospholipase 2
chr3_-_52770856 Show fit	1.91	ENST00000461689.5 ENST00000535191.5 ENST00000383721.8 ENST00000233027.10	NEK4 Ensembl NCBI GeneCards UniProt Show fit	NIMA related kinase 4
chr21_-_14546351 Show fit	1.90	ENST00000619120.4	SAMSN1 Ensembl NCBI GeneCards UniProt Show fit	SAM domain, SH3 domain and nuclear localization signals 1
chr5_-_88785493 Show fit	1.89	ENST00000503554.4	MEF2C Ensembl NCBI GeneCards UniProt Show fit	myocyte enhancer factor 2C
chr1_+_23791203 Show fit	1.88	ENST00000374503.7 ENST00000374502.7	LYPLA2 Ensembl NCBI GeneCards UniProt Show fit	lysophospholipase 2
chr6_+_26199509 Show fit	1.87	ENST00000356530.5	H2BC7 Ensembl NCBI GeneCards UniProt Show fit	H2B clustered histone 7
chr9_+_130693756 Show fit	1.85	ENST00000546165.5 ENST00000372352.7 ENST00000372358.10 ENST00000372351.7 ENST00000372350.7 ENST00000495699.2	EXOSC2 Ensembl NCBI GeneCards UniProt Show fit	exosome component 2
chr12_+_65169546 Show fit	1.85	ENST00000308330.3	LEMD3 Ensembl NCBI GeneCards UniProt Show fit	LEM domain containing 3
chr8_+_7768977 Show fit	1.80	ENST00000533716.2	FAM90A10P Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 90 member A10, pseudogene
chr6_-_56851888 Show fit	1.79	ENST00000312431.10 ENST00000520645.5	DST Ensembl NCBI GeneCards UniProt Show fit	dystonin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
20.9	62.7	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
5.7	17.2	GO:0090149	synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
5.5	16.6	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
3.3	13.4	GO:0090202	transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
2.9	23.3	GO:0006348	chromatin silencing at telomere(GO:0006348)
2.8	8.3	GO:0036245	cellular response to menadione(GO:0036245)
2.6	15.7	GO:0010032	meiotic chromosome condensation(GO:0010032)
2.5	12.5	GO:0006177	GMP biosynthetic process(GO:0006177)
2.2	10.9	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
2.1	14.5	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
2.1	14.4	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)
2.0	12.3	GO:0048254	snoRNA localization(GO:0048254)
2.0	16.2	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051343)
1.9	5.7	GO:0060279	regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.8	11.0	GO:1900368	regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
1.8	7.3	GO:0000467	exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038)
1.8	5.3	GO:2000395	ubiquitin-dependent endocytosis(GO:0070086) positive regulation of viral budding via host ESCRT complex(GO:1903774) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
1.7	15.5	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
1.7	5.0	GO:0071461	cellular response to redox state(GO:0071461)
1.5	6.2	GO:0009181	purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
1.5	21.4	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
1.4	7.0	GO:0044209	AMP salvage(GO:0044209)
1.3	7.9	GO:0051177	meiotic sister chromatid cohesion(GO:0051177)
1.3	42.4	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
1.2	9.7	GO:0001887	selenium compound metabolic process(GO:0001887)
1.2	10.5	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
1.1	5.3	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
1.0	14.0	GO:1904871	regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
1.0	5.0	GO:0031291	Ran protein signal transduction(GO:0031291)
1.0	6.8	GO:0032328	alanine transport(GO:0032328)
1.0	2.9	GO:0014016	neuroblast differentiation(GO:0014016)
1.0	13.3	GO:2000774	positive regulation of cellular senescence(GO:2000774)
0.9	6.6	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.9	42.2	GO:0031577	spindle checkpoint(GO:0031577)
0.9	7.5	GO:0002759	regulation of antimicrobial humoral response(GO:0002759)
0.9	5.5	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.9	4.6	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.9	10.7	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)
0.9	2.6	GO:2000619	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) negative regulation of histone H4-K16 acetylation(GO:2000619)
0.8	15.6	GO:0006183	GTP biosynthetic process(GO:0006183)
0.8	2.4	GO:0016487	sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.8	12.7	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.8	11.8	GO:0006983	ER overload response(GO:0006983)
0.8	9.8	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.8	4.5	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.7	2.2	GO:0006059	hexitol metabolic process(GO:0006059)
0.7	17.7	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.7	12.9	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.7	3.5	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.7	6.9	GO:0044800	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.7	3.3	GO:2000035	regulation of stem cell division(GO:2000035)
0.6	5.2	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.6	6.3	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.6	4.9	GO:2000210	positive regulation of anoikis(GO:2000210)
0.6	10.7	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.6	8.9	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.5	4.8	GO:0010265	SCF complex assembly(GO:0010265)
0.5	40.5	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.5	7.7	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.5	4.0	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.5	3.8	GO:0002084	protein depalmitoylation(GO:0002084)
0.5	3.3	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.5	11.3	GO:0043101	purine-containing compound salvage(GO:0043101)
0.5	1.4	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.5	2.7	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.4	2.2	GO:0001971	negative regulation of activation of membrane attack complex(GO:0001971)
0.4	5.2	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.4	2.1	GO:0014886	transition between slow and fast fiber(GO:0014886)
0.4	19.3	GO:0014904	myotube cell development(GO:0014904)
0.4	1.6	GO:2000393	negative regulation of lamellipodium morphogenesis(GO:2000393)
0.4	10.4	GO:0036120	cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.4	4.2	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.4	3.0	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.4	1.8	GO:0044821	meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.4	9.5	GO:0042276	error-prone translesion synthesis(GO:0042276) error-free translesion synthesis(GO:0070987)
0.3	3.1	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3	2.6	GO:0050713	negative regulation of interleukin-1 beta secretion(GO:0050713)
0.3	1.9	GO:0001302	replicative cell aging(GO:0001302)
0.3	1.3	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.3	1.6	GO:1990426	homologous recombination-dependent replication fork processing(GO:1990426)
0.3	2.2	GO:1900045	negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.3	5.6	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.3	6.5	GO:0072697	protein localization to cell cortex(GO:0072697)
0.3	3.4	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.3	0.9	GO:0072717	cellular response to actinomycin D(GO:0072717)
0.3	19.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3	3.7	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.3	6.7	GO:0032802	low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.2	3.7	GO:1903760	regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.2	8.2	GO:0031055	chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.2	1.9	GO:0003185	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) positive regulation of macrophage apoptotic process(GO:2000111)
0.2	10.2	GO:0032731	positive regulation of interleukin-1 beta production(GO:0032731)
0.2	4.1	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.2	1.1	GO:0097461	ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2	2.0	GO:0000012	single strand break repair(GO:0000012)
0.2	5.9	GO:0000042	protein targeting to Golgi(GO:0000042)
0.2	8.5	GO:0035666	TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.2	3.6	GO:0031639	plasminogen activation(GO:0031639)
0.2	8.7	GO:0002026	regulation of the force of heart contraction(GO:0002026)
0.2	3.4	GO:0030903	notochord development(GO:0030903)
0.2	2.4	GO:0060712	spongiotrophoblast layer development(GO:0060712)
0.2	5.4	GO:0060065	uterus development(GO:0060065)
0.2	24.8	GO:0007093	mitotic cell cycle checkpoint(GO:0007093)
0.2	2.4	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.2	4.0	GO:0006293	nucleotide-excision repair, preincision complex stabilization(GO:0006293)
0.2	1.4	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.2	10.0	GO:0043631	mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.2	1.7	GO:0021730	trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1	1.8	GO:0008090	retrograde axonal transport(GO:0008090)
0.1	6.5	GO:0006409	tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1	2.0	GO:0045116	protein neddylation(GO:0045116)
0.1	4.7	GO:0033198	response to ATP(GO:0033198)
0.1	0.7	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.1	0.7	GO:0035803	egg coat formation(GO:0035803)
0.1	9.6	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.1	2.2	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1	4.4	GO:0050869	negative regulation of B cell activation(GO:0050869)
0.1	2.6	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	3.2	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1	5.4	GO:0030195	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1	2.3	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.1	2.9	GO:0032461	positive regulation of protein oligomerization(GO:0032461)
0.1	1.5	GO:0002227	innate immune response in mucosa(GO:0002227)
0.1	0.3	GO:0010979	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.1	1.1	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.1	3.6	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1	7.1	GO:0002181	cytoplasmic translation(GO:0002181)
0.1	0.6	GO:0009804	coumarin metabolic process(GO:0009804) flavone metabolic process(GO:0051552)
0.1	2.8	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.1	2.2	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.1	0.2	GO:0034444	regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.1	0.8	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.7	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.1	1.4	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.1	0.3	GO:0019376	galactolipid catabolic process(GO:0019376)
0.1	1.6	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1	0.4	GO:2000253	positive regulation of feeding behavior(GO:2000253)
0.1	4.6	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1	5.5	GO:0006406	mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1	0.6	GO:0051601	exocyst localization(GO:0051601)
0.1	0.4	GO:2000768	glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.0	0.8	GO:0060009	Sertoli cell development(GO:0060009)
0.0	4.9	GO:0051168	nuclear export(GO:0051168)
0.0	1.0	GO:0051764	actin crosslink formation(GO:0051764)
0.0	4.8	GO:0030183	B cell differentiation(GO:0030183)
0.0	2.3	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0	0.7	GO:0039703	viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0	0.8	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	1.2	GO:0003341	cilium movement(GO:0003341)
0.0	0.9	GO:0002076	osteoblast development(GO:0002076)
0.0	0.3	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	1.4	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	2.5	GO:0030038	contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0	0.5	GO:0006337	nucleosome disassembly(GO:0006337)
0.0	3.5	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.7	GO:0006656	phosphatidylcholine biosynthetic process(GO:0006656)
0.0	0.1	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.5	GO:0045599	negative regulation of fat cell differentiation(GO:0045599)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.0	21.1	GO:0033597	mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
6.3	62.7	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
6.0	23.9	GO:1990423	RZZ complex(GO:1990423)
5.2	15.7	GO:0000799	nuclear condensin complex(GO:0000799)
5.2	15.5	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
2.9	14.5	GO:0005726	perichromatin fibrils(GO:0005726)
2.8	19.3	GO:0005663	DNA replication factor C complex(GO:0005663)
2.3	11.3	GO:1902560	GMP reductase complex(GO:1902560)
2.2	13.3	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
2.1	12.9	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
2.1	16.6	GO:0005827	polar microtubule(GO:0005827)
2.0	10.1	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
1.9	5.7	GO:0043511	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.8	16.2	GO:1990630	IRE1-RACK1-PP2A complex(GO:1990630)
1.8	12.3	GO:0070761	pre-snoRNP complex(GO:0070761)
1.7	13.4	GO:0097255	R2TP complex(GO:0097255)
1.6	6.5	GO:1990876	cytoplasmic side of nuclear pore(GO:1990876)
1.6	11.0	GO:0044530	supraspliceosomal complex(GO:0044530)
1.4	21.4	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
1.3	5.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
1.2	9.9	GO:0000243	commitment complex(GO:0000243)
1.1	10.0	GO:0042382	paraspeckles(GO:0042382)
1.1	14.0	GO:0002199	zona pellucida receptor complex(GO:0002199)
1.0	14.4	GO:0070531	BRCA1-A complex(GO:0070531)
1.0	12.7	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.9	37.7	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.9	11.2	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.9	9.8	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.7	6.5	GO:0072546	ER membrane protein complex(GO:0072546)
0.7	7.8	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.7	4.6	GO:1990111	spermatoproteasome complex(GO:1990111)
0.6	5.3	GO:0000813	ESCRT I complex(GO:0000813)
0.6	3.5	GO:0032279	asymmetric synapse(GO:0032279)
0.6	4.5	GO:0070522	nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.6	7.3	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.5	6.6	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.5	3.2	GO:0033063	DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.5	1.6	GO:0033593	BRCA2-MAGE-D1 complex(GO:0033593)
0.5	2.6	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.5	4.6	GO:0070765	gamma-secretase complex(GO:0070765)
0.5	8.9	GO:0030127	COPII vesicle coat(GO:0030127)
0.5	37.3	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.4	2.2	GO:0097454	Schwann cell microvillus(GO:0097454)
0.4	1.8	GO:0031673	H zone(GO:0031673)
0.3	4.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.3	5.2	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3	6.7	GO:0036020	endolysosome membrane(GO:0036020)
0.3	2.6	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.3	2.1	GO:0072487	MSL complex(GO:0072487)
0.2	17.2	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2	1.4	GO:0097165	nuclear stress granule(GO:0097165)
0.2	4.0	GO:0008091	spectrin(GO:0008091)
0.2	2.4	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2	12.6	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2	5.0	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.2	19.6	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.2	3.7	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.2	23.3	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.2	3.7	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	2.9	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	1.4	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1	9.0	GO:0000792	heterochromatin(GO:0000792)
0.1	13.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	9.2	GO:0031672	A band(GO:0031672)
0.1	19.2	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1	2.9	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1	2.3	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.1	9.6	GO:0000502	proteasome complex(GO:0000502)
0.1	2.5	GO:0031305	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1	1.8	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1	8.2	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.1	6.3	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	0.8	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.1	1.7	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.1	0.6	GO:0035976	AP1 complex(GO:0035976)
0.1	7.6	GO:0005814	centriole(GO:0005814)
0.1	1.4	GO:0030992	intraciliary transport particle B(GO:0030992)
0.1	5.2	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.1	0.2	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.1	25.4	GO:0016607	nuclear speck(GO:0016607)
0.1	0.7	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1	1.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	27.5	GO:0005635	nuclear envelope(GO:0005635)
0.1	7.7	GO:0001650	fibrillar center(GO:0001650)
0.1	1.6	GO:0043218	compact myelin(GO:0043218)
0.1	7.5	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	4.2	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.6	GO:0000145	exocyst(GO:0000145)
0.0	1.2	GO:0030286	dynein complex(GO:0030286)
0.0	8.0	GO:0005770	late endosome(GO:0005770)
0.0	3.2	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.3	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	2.7	GO:0070821	tertiary granule membrane(GO:0070821)
0.0	6.7	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	5.3	GO:0042383	sarcolemma(GO:0042383)
0.0	0.4	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	3.3	GO:0005681	spliceosomal complex(GO:0005681)
0.0	0.5	GO:0043198	dendritic shaft(GO:0043198)
0.0	1.3	GO:0005875	microtubule associated complex(GO:0005875)
0.0	0.8	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	1.0	GO:0070382	exocytic vesicle(GO:0070382)
0.0	1.1	GO:0043197	dendritic spine(GO:0043197)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
20.9	62.7	GO:0098808	mRNA cap binding(GO:0098808)
5.5	16.6	GO:0031208	POZ domain binding(GO:0031208)
3.6	10.7	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
3.2	12.9	GO:0016418	S-acetyltransferase activity(GO:0016418)
3.1	12.5	GO:0003938	IMP dehydrogenase activity(GO:0003938)
3.1	15.5	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
2.8	11.2	GO:0043515	kinetochore binding(GO:0043515)
2.8	19.3	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.7	13.4	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
2.3	11.3	GO:0003920	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
1.9	19.3	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.8	7.0	GO:0002060	purine nucleobase binding(GO:0002060)
1.7	10.5	GO:1990446	U1 snRNP binding(GO:1990446)
1.6	9.9	GO:0032038	myosin II heavy chain binding(GO:0032038)
1.6	4.9	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
1.6	16.2	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
1.6	14.5	GO:0034056	estrogen response element binding(GO:0034056)
1.6	12.7	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
1.5	16.8	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
1.4	11.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
1.3	23.8	GO:0051400	BH domain binding(GO:0051400)
1.1	7.9	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
1.1	3.3	GO:0045131	pre-mRNA branch point binding(GO:0045131)
1.1	24.7	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
1.0	4.9	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
1.0	15.6	GO:1901612	cardiolipin binding(GO:1901612)
0.9	4.7	GO:0043208	glycosphingolipid binding(GO:0043208)
0.9	5.5	GO:0035800	deubiquitinase activator activity(GO:0035800)
0.9	8.3	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.9	9.7	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.9	2.6	GO:0032089	NACHT domain binding(GO:0032089)
0.8	5.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.8	2.4	GO:0045550	geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.8	6.4	GO:0070699	type II activin receptor binding(GO:0070699)
0.7	0.7	GO:0098847	sequence-specific single stranded DNA binding(GO:0098847)
0.7	2.2	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.7	2.9	GO:0033265	acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.7	21.4	GO:0070034	telomerase RNA binding(GO:0070034)
0.7	2.8	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.7	3.5	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.7	2.0	GO:0070259	tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.7	4.6	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.6	5.2	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.6	5.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6	14.4	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.6	6.9	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.5	2.6	GO:0019776	Atg8 ligase activity(GO:0019776)
0.5	8.8	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.4	6.5	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.4	22.7	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4	5.3	GO:0046790	virion binding(GO:0046790)
0.4	4.0	GO:0042731	PH domain binding(GO:0042731)
0.4	14.0	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.3	2.2	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3	7.4	GO:0004659	prenyltransferase activity(GO:0004659)
0.3	15.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.3	6.7	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3	4.8	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3	1.1	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3	0.8	GO:0019150	D-ribulokinase activity(GO:0019150)
0.3	9.8	GO:0005540	hyaluronic acid binding(GO:0005540)
0.3	1.3	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.2	0.7	GO:0052739	phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.2	49.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	2.3	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.2	10.7	GO:0004364	glutathione transferase activity(GO:0004364)
0.2	7.3	GO:0000175	3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.2	3.7	GO:0097016	L27 domain binding(GO:0097016)
0.2	3.7	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2	2.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2	20.4	GO:0043130	ubiquitin binding(GO:0043130)
0.2	4.6	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2	1.4	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1	2.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.1	4.8	GO:0017025	TBP-class protein binding(GO:0017025)
0.1	1.6	GO:0033038	bitter taste receptor activity(GO:0033038)
0.1	0.3	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	5.2	GO:0042169	SH2 domain binding(GO:0042169)
0.1	6.1	GO:0042162	telomeric DNA binding(GO:0042162)
0.1	2.3	GO:0042809	vitamin D receptor binding(GO:0042809)
0.1	3.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.1	1.9	GO:0003680	AT DNA binding(GO:0003680)
0.1	5.0	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.1	5.0	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	6.3	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1	1.0	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.1	4.0	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.1	8.9	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	2.4	GO:0003746	translation elongation factor activity(GO:0003746)
0.1	2.7	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.1	18.3	GO:0042393	histone binding(GO:0042393)
0.1	2.2	GO:0001848	complement binding(GO:0001848)
0.1	0.7	GO:0032190	acrosin binding(GO:0032190)
0.1	1.7	GO:0008198	ferrous iron binding(GO:0008198)
0.1	2.2	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.1	1.8	GO:0051010	microtubule plus-end binding(GO:0051010)
0.1	4.0	GO:0005504	fatty acid binding(GO:0005504)
0.1	1.2	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1	3.4	GO:0050699	WW domain binding(GO:0050699)
0.1	3.0	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	4.3	GO:0016278	lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1	6.8	GO:0015171	amino acid transmembrane transporter activity(GO:0015171)
0.1	2.2	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.1	5.4	GO:0042826	histone deacetylase binding(GO:0042826)
0.1	10.2	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	1.4	GO:0017091	AU-rich element binding(GO:0017091)
0.1	2.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	10.0	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0	4.1	GO:0008135	translation factor activity, RNA binding(GO:0008135)
0.0	0.6	GO:0030280	structural constituent of epidermis(GO:0030280)
0.0	3.6	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0	0.7	GO:0016805	dipeptidase activity(GO:0016805)
0.0	1.9	GO:0030145	manganese ion binding(GO:0030145)
0.0	0.3	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.0	1.8	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.6	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.6	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	2.5	GO:0008013	beta-catenin binding(GO:0008013)
0.0	4.9	GO:0005178	integrin binding(GO:0005178)
0.0	0.1	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	1.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	1.5	GO:0002020	protease binding(GO:0002020)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	32.4	PID AURORA B PATHWAY	Aurora B signaling
0.4	14.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	12.5	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	17.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.3	11.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	20.1	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.3	8.4	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.3	13.4	PID MYC PATHWAY	C-MYC pathway
0.2	9.4	PID ATM PATHWAY	ATM pathway
0.2	4.6	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.2	15.2	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	5.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	3.7	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	6.5	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.2	4.8	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2	20.3	PID P73PATHWAY	p73 transcription factor network
0.2	13.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.2	5.6	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	5.7	PID ALK1 PATHWAY	ALK1 signaling events
0.1	8.2	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.1	2.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	3.6	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	12.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.9	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	2.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.8	PID P53 REGULATION PATHWAY	p53 pathway
0.0	0.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	1.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	2.7	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	1.9	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	13.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
1.3	15.6	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
1.1	6.9	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.8	12.5	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.8	58.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.8	25.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.8	18.3	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.8	12.9	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.8	5.3	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.8	21.1	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.7	12.7	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
0.7	10.9	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.7	24.5	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.7	10.4	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.6	13.4	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.5	5.7	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.4	14.0	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4	9.8	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.3	5.0	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.3	4.5	REACTOME TRANSCRIPTION COUPLED NER TC NER	Genes involved in Transcription-coupled NER (TC-NER)
0.3	9.5	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.3	8.9	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3	3.5	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3	8.5	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3	5.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3	6.5	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.3	22.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.3	6.7	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.3	4.8	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.2	13.9	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.2	23.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	6.8	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.2	7.8	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.2	5.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	2.8	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.2	6.1	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2	3.1	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2	32.6	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.2	2.9	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2	15.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	4.4	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1	2.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	3.7	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	2.9	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.0	REACTOME DOUBLE STRAND BREAK REPAIR	Genes involved in Double-Strand Break Repair
0.1	24.9	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	7.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	3.7	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.1	8.0	REACTOME APOPTOTIC EXECUTION PHASE	Genes involved in Apoptotic execution phase
0.1	1.7	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	2.2	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	3.2	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	1.4	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1	1.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	1.9	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	4.7	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.0	1.0	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	1.1	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	6.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	3.6	REACTOME HEMOSTASIS	Genes involved in Hemostasis
0.0	0.6	REACTOME DEFENSINS	Genes involved in Defensins
0.0	0.7	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.7	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	1.4	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production

Results for HOXC12_HOXD12

Z-value: 6.21

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Transcription factors associated with HOXC12_HOXD12

Activity-expression correlation:

Activity profile of HOXC12_HOXD12 motif

Sorted Z-values of HOXC12_HOXD12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXC12_HOXD12

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: