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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXD10

Z-value: 0.43

Motif logo

Transcription factors associated with HOXD10

Gene Symbol Gene ID Gene Info
ENSG00000128710.6 HOXD10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD10hg38_v1_chr2_+_176116768_176116794-0.195.8e-03Click!

Activity profile of HOXD10 motif

Sorted Z-values of HOXD10 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD10

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_-_32589833 15.20 ENST00000360004.5
major histocompatibility complex, class II, DR beta 1
chr1_+_198638968 12.96 ENST00000348564.11
ENST00000530727.5
ENST00000442510.8
ENST00000645247.1
ENST00000367367.8
ENST00000367364.5
ENST00000413409.6
protein tyrosine phosphatase receptor type C
chr4_-_83114715 11.31 ENST00000426923.2
ENST00000311507.9
ENST00000509973.5
placenta associated 8
chr6_-_32530268 11.15 ENST00000374975.4
major histocompatibility complex, class II, DR beta 5
chr4_+_40196907 9.71 ENST00000622175.4
ENST00000619474.4
ENST00000615083.4
ENST00000610353.4
ENST00000614836.1
ras homolog family member H
chr8_-_100706763 9.57 ENST00000517990.5
poly(A) binding protein cytoplasmic 1
chr1_-_111200633 9.33 ENST00000357640.9
DENN domain containing 2D
chr1_+_159008978 8.79 ENST00000447473.6
interferon gamma inducible protein 16
chr8_-_100706931 8.35 ENST00000520868.5
poly(A) binding protein cytoplasmic 1
chr13_-_40982880 7.68 ENST00000635415.1
E74 like ETS transcription factor 1
chr18_+_3252267 7.06 ENST00000536605.1
ENST00000580887.5
myosin light chain 12A
chr4_+_40197023 6.78 ENST00000381799.10
ras homolog family member H
chr2_-_89085787 6.77 ENST00000390252.2
immunoglobulin kappa variable 3-15
chr12_-_91153149 6.64 ENST00000550758.1
decorin
chr12_+_21372899 6.34 ENST00000240652.8
ENST00000542023.1
ENST00000537593.1
islet amyloid polypeptide
chr15_-_55270280 6.34 ENST00000564609.5
RAB27A, member RAS oncogene family
chr8_-_100722731 5.87 ENST00000521865.6
ENST00000520804.2
ENST00000522720.2
ENST00000521067.1
poly(A) binding protein cytoplasmic 1
chr8_-_100722587 5.86 ENST00000523555.6
poly(A) binding protein cytoplasmic 1
chr6_-_32668368 5.76 ENST00000399084.5
major histocompatibility complex, class II, DQ beta 1
chr2_+_87338511 5.64 ENST00000421835.2
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr16_-_24930952 5.59 ENST00000571406.1
Rho GTPase activating protein 17
chr2_+_90234809 5.50 ENST00000443397.5
immunoglobulin kappa variable 3D-7
chr11_+_60455839 5.49 ENST00000532491.5
ENST00000532073.5
ENST00000345732.9
ENST00000534668.6
ENST00000528313.1
ENST00000533306.6
ENST00000674194.1
membrane spanning 4-domains A1
chr5_+_168486462 5.49 ENST00000231572.8
ENST00000626454.1
arginyl-tRNA synthetase 1
chrX_+_23667461 5.48 ENST00000379341.9
ENST00000379331.3
peroxiredoxin 4
chr1_+_40738834 5.33 ENST00000525290.5
ENST00000530965.5
ENST00000416859.6
ENST00000308733.9
nuclear transcription factor Y subunit gamma
chr6_-_36547400 5.24 ENST00000229812.8
serine/threonine kinase 38
chr6_-_25042003 5.10 ENST00000510784.8
RHO family interacting cell polarization regulator 2
chr6_+_26103922 4.97 ENST00000377803.4
H4 clustered histone 3
chr3_+_30606574 4.93 ENST00000295754.10
ENST00000359013.4
transforming growth factor beta receptor 2
chr2_+_68734773 4.93 ENST00000409202.8
Rho GTPase activating protein 25
chrX_-_154371210 4.86 ENST00000369856.8
ENST00000422373.6
ENST00000360319.9
filamin A
chr3_-_123980727 4.85 ENST00000620893.4
rhophilin associated tail protein 1
chr3_-_185923893 4.72 ENST00000259043.11
transformer 2 beta homolog
chr8_+_73991345 4.71 ENST00000284818.7
ENST00000518893.1
lymphocyte antigen 96
chr5_+_163503075 4.59 ENST00000280969.9
methionine adenosyltransferase 2B
chr2_+_68365274 4.28 ENST00000234313.8
pleckstrin
chr6_+_26365215 4.26 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr6_+_26365176 4.24 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr11_+_17295322 4.19 ENST00000458064.6
ENST00000622082.4
nucleobindin 2
chr12_-_9869345 4.18 ENST00000228438.3
C-type lectin domain family 2 member B
chr7_+_77840122 4.10 ENST00000450574.5
ENST00000248550.7
putative homeodomain transcription factor 2
chr2_-_88979016 4.05 ENST00000390247.2
immunoglobulin kappa variable 3-7 (non-functional)
chr17_-_10549652 3.93 ENST00000245503.10
myosin heavy chain 2
chr12_-_7503744 3.90 ENST00000396620.7
ENST00000432237.3
CD163 molecule
chr2_+_101839815 3.89 ENST00000421882.5
mitogen-activated protein kinase kinase kinase kinase 4
chr6_-_132763424 3.87 ENST00000532012.1
ENST00000525270.5
ENST00000530536.5
ENST00000524919.5
vanin 2
chr17_-_10549612 3.84 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
myosin heavy chain 2
chr10_+_78035506 3.81 ENST00000645195.1
ribosomal protein S24
chr12_-_7503841 3.80 ENST00000359156.8
CD163 molecule
chr15_+_64387828 3.76 ENST00000261884.8
thyroid hormone receptor interactor 4
chr6_-_149746497 3.75 ENST00000367404.8
ENST00000340413.7
ENST00000543637.1
nucleoporin 43
chrX_-_101617921 3.67 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
armadillo repeat containing X-linked 6
chr3_+_158571215 3.67 ENST00000498592.6
ENST00000478894.7
myeloid leukemia factor 1
chr6_+_143677935 3.63 ENST00000440869.6
ENST00000367582.7
ENST00000451827.6
phosphatase and actin regulator 2
chr2_+_90172802 3.62 ENST00000390277.3
immunoglobulin kappa variable 3D-11
chrX_+_37780049 3.59 ENST00000378588.5
cytochrome b-245 beta chain
chr17_-_10549694 3.51 ENST00000622564.4
myosin heavy chain 2
chr10_-_43396831 3.42 ENST00000443950.6
heterogeneous nuclear ribonucleoprotein F
chr7_+_92057602 3.37 ENST00000491695.2
A-kinase anchoring protein 9
chr7_-_100100716 3.36 ENST00000354230.7
ENST00000425308.5
minichromosome maintenance complex component 7
chr12_+_20810698 3.25 ENST00000540853.5
ENST00000381545.8
solute carrier organic anion transporter family member 1B3
chr4_-_71784046 3.10 ENST00000513476.5
ENST00000273951.13
GC vitamin D binding protein
chr5_+_157180816 3.08 ENST00000422843.8
IL2 inducible T cell kinase
chr12_-_13095628 3.07 ENST00000457134.6
ENST00000537302.5
germ cell associated 1
chr10_-_103153609 3.06 ENST00000675985.1
5'-nucleotidase, cytosolic II
chr11_-_64879709 3.04 ENST00000621096.4
EH domain containing 1
chr12_-_13095798 3.01 ENST00000396302.7
germ cell associated 1
chr1_+_153990749 2.85 ENST00000651669.1
ribosomal protein S27
chr11_-_64879675 2.77 ENST00000359393.6
ENST00000433803.1
ENST00000411683.1
EH domain containing 1
chr11_+_9575496 2.63 ENST00000681684.1
WEE1 G2 checkpoint kinase
chr2_+_182716227 2.63 ENST00000680258.1
ENST00000680667.1
ENST00000264065.12
ENST00000616986.5
ENST00000679884.1
DnaJ heat shock protein family (Hsp40) member C10
chr1_+_51617079 2.61 ENST00000447887.5
ENST00000428468.6
ENST00000453295.5
oxysterol binding protein like 9
chr10_+_35167516 2.59 ENST00000361599.8
cAMP responsive element modulator
chr12_+_15956585 2.57 ENST00000526530.1
deoxyribose-phosphate aldolase
chr18_+_3252208 2.56 ENST00000578562.6
myosin light chain 12A
chrX_+_154398367 2.49 ENST00000436473.5
ENST00000344746.8
ENST00000369817.7
ENST00000458500.5
ribosomal protein L10
chr1_-_229434086 2.48 ENST00000366684.7
ENST00000684723.1
ENST00000366683.4
actin alpha 1, skeletal muscle
chrX_+_11760087 2.44 ENST00000649271.1
MSL complex subunit 3
chr12_+_103965835 2.40 ENST00000266775.13
ENST00000544861.5
thymine DNA glycosylase
chr12_-_91182784 2.34 ENST00000547568.6
ENST00000052754.10
ENST00000552962.5
decorin
chr8_+_11809135 2.32 ENST00000528643.5
ENST00000525777.5
farnesyl-diphosphate farnesyltransferase 1
chr3_+_136930469 2.30 ENST00000469404.1
ENST00000467911.1
NCK adaptor protein 1
chr7_-_115968302 2.30 ENST00000457268.5
transcription factor EC
chr17_+_50746534 2.29 ENST00000511974.5
LUC7 like 3 pre-mRNA splicing factor
chr3_+_63967738 2.26 ENST00000484332.1
ataxin 7
chr14_+_88594395 2.26 ENST00000318308.10
zinc finger CCCH-type containing 14
chr8_-_123025750 2.21 ENST00000523036.1
derlin 1
chrX_+_11760035 2.21 ENST00000482871.6
ENST00000648013.1
MSL complex subunit 3
chr3_+_158571153 2.18 ENST00000491767.6
ENST00000618075.4
myeloid leukemia factor 1
chr8_+_26293112 2.18 ENST00000523925.5
ENST00000315985.7
protein phosphatase 2 regulatory subunit Balpha
chr15_+_57219411 2.16 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
transcription factor 12
chr7_-_38249572 2.15 ENST00000436911.6
T cell receptor gamma constant 2
chr1_+_45913647 2.14 ENST00000674079.1
microtubule associated serine/threonine kinase 2
chr3_+_123067016 2.13 ENST00000316218.12
protein disulfide isomerase family A member 5
chr1_+_78649818 2.12 ENST00000370747.9
ENST00000438486.1
interferon induced protein 44
chr6_+_25962792 2.01 ENST00000357085.5
tripartite motif containing 38
chr4_-_76007501 2.00 ENST00000264888.6
C-X-C motif chemokine ligand 9
chr2_+_86106217 1.99 ENST00000409783.6
ENST00000254630.12
ENST00000627371.1
pentatricopeptide repeat domain 3
chr10_+_119207560 1.96 ENST00000392870.3
G protein-coupled receptor kinase 5
chr3_-_167474026 1.96 ENST00000466903.1
ENST00000264677.8
serpin family I member 2
chr3_+_158571171 1.93 ENST00000484955.5
ENST00000359117.9
ENST00000619577.5
ENST00000471745.5
ENST00000477042.6
ENST00000650753.1
ENST00000651984.1
ENST00000355893.11
ENST00000466246.7
ENST00000469452.5
ENST00000482628.5
myeloid leukemia factor 1
chr7_-_103344588 1.92 ENST00000426036.6
ENST00000249270.11
ENST00000379263.8
ENST00000454277.5
ENST00000412522.1
DnaJ heat shock protein family (Hsp40) member C2
chr17_-_64505357 1.92 ENST00000583212.2
ENST00000578190.5
ENST00000579091.5
ENST00000583239.6
DEAD-box helicase 5
chr9_-_101435760 1.91 ENST00000647789.2
ENST00000616752.1
aldolase, fructose-bisphosphate B
chr22_+_32475257 1.91 ENST00000397426.5
F-box protein 7
chr6_-_134318097 1.91 ENST00000367858.10
ENST00000533224.1
serum/glucocorticoid regulated kinase 1
chr13_-_75366973 1.88 ENST00000648194.1
TBC1 domain family member 4
chr12_+_14365729 1.86 ENST00000536444.5
activating transcription factor 7 interacting protein
chrX_-_50200988 1.84 ENST00000358526.7
A-kinase anchoring protein 4
chr9_+_4839761 1.78 ENST00000448872.6
ENST00000441844.2
RNA terminal phosphate cyclase like 1
chr19_+_33373694 1.76 ENST00000284000.9
CCAAT enhancer binding protein gamma
chr17_+_50746614 1.75 ENST00000513969.5
ENST00000503728.1
LUC7 like 3 pre-mRNA splicing factor
chr12_-_8949628 1.74 ENST00000000412.8
ENST00000543845.1
ENST00000544245.1
ENST00000536844.5
mannose-6-phosphate receptor, cation dependent
chr4_+_99574812 1.70 ENST00000422897.6
ENST00000265517.10
microsomal triglyceride transfer protein
chr2_-_189179754 1.68 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chr7_+_95485898 1.65 ENST00000428113.5
ankyrin repeat and SOCS box containing 4
chr4_+_118034480 1.62 ENST00000296499.6
N-deacetylase and N-sulfotransferase 3
chr3_-_134250744 1.59 ENST00000620660.4
receptor like tyrosine kinase
chr10_-_75109085 1.57 ENST00000607131.5
dual specificity phosphatase 13
chr11_+_122882683 1.56 ENST00000307257.10
ENST00000227349.7
junctional cadherin complex regulator
chr10_-_93482194 1.55 ENST00000358334.9
ENST00000371488.3
myoferlin
chr3_+_184300564 1.52 ENST00000435761.5
ENST00000439383.5
proteasome 26S subunit, non-ATPase 2
chr14_+_73097027 1.50 ENST00000532192.1
RNA binding motif protein 25
chr11_-_30586866 1.50 ENST00000528686.2
metallophosphoesterase domain containing 2
chr1_+_74235377 1.50 ENST00000326637.8
TNNI3 interacting kinase
chr12_+_64497968 1.45 ENST00000676593.1
ENST00000677093.1
TANK binding kinase 1
novel transcript
chr8_+_109086585 1.45 ENST00000518632.2
thyrotropin releasing hormone receptor
chr11_+_121102666 1.42 ENST00000264037.2
tectorin alpha
chr1_+_153416517 1.42 ENST00000368729.9
S100 calcium binding protein A7A
chr7_-_23347704 1.40 ENST00000619562.4
insulin like growth factor 2 mRNA binding protein 3
chr12_-_118359639 1.40 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr9_-_92424427 1.38 ENST00000375550.5
osteomodulin
chr10_+_96304425 1.38 ENST00000371174.5
DNA nucleotidylexotransferase
chr16_+_4846652 1.35 ENST00000592120.5
ubinuclein 1
chr13_+_77535742 1.35 ENST00000377246.7
sciellin
chr19_-_51082883 1.34 ENST00000650543.2
kallikrein related peptidase 14
chr18_+_616711 1.34 ENST00000579494.1
clusterin like 1
chr3_+_108822759 1.34 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr12_-_13095664 1.33 ENST00000337630.10
ENST00000545699.1
germ cell associated 1
chrX_+_12906612 1.33 ENST00000218032.7
toll like receptor 8
chr13_+_77535669 1.33 ENST00000535157.5
sciellin
chr13_+_77535681 1.33 ENST00000349847.4
sciellin
chr11_-_13495984 1.32 ENST00000282091.6
parathyroid hormone
chr7_+_55365317 1.30 ENST00000254770.3
LanC like 2
chr3_-_99850976 1.28 ENST00000487087.5
filamin A interacting protein 1 like
chr3_-_165078480 1.28 ENST00000264382.8
sucrase-isomaltase
chr18_+_41955186 1.26 ENST00000639914.1
ENST00000262039.9
ENST00000398870.7
ENST00000586545.5
ENST00000585528.5
phosphatidylinositol 3-kinase catalytic subunit type 3
chr8_-_116874746 1.26 ENST00000297338.7
RAD21 cohesin complex component
chr7_-_6826770 1.25 ENST00000626257.2
CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated
chr4_-_67883987 1.24 ENST00000283916.11
transmembrane serine protease 11D
chr2_+_1414382 1.24 ENST00000423320.5
ENST00000346956.7
ENST00000382198.5
thyroid peroxidase
chr3_+_108822778 1.24 ENST00000295756.11
T cell receptor associated transmembrane adaptor 1
chr2_+_218710931 1.23 ENST00000442769.5
ENST00000424644.1
tubulin tyrosine ligase like 4
chr6_+_63521738 1.23 ENST00000648894.1
ENST00000639568.2
protein tyrosine phosphatase 4A1
chr12_-_91178520 1.22 ENST00000425043.5
ENST00000420120.6
ENST00000441303.6
ENST00000456569.2
decorin
chr6_+_118548289 1.22 ENST00000357525.6
phospholamban
chr15_+_94297939 1.20 ENST00000357742.9
multiple C2 and transmembrane domain containing 2
chr13_+_111186773 1.14 ENST00000426073.6
Rho guanine nucleotide exchange factor 7
chr15_-_28174423 1.14 ENST00000569772.1
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr2_+_121755545 1.13 ENST00000536142.5
ENST00000389682.8
translin
chr9_-_92482350 1.11 ENST00000375543.2
asporin
chr17_-_7080275 1.11 ENST00000571664.1
ENST00000254868.8
C-type lectin domain containing 10A
chr6_-_130970428 1.11 ENST00000529208.5
erythrocyte membrane protein band 4.1 like 2
chr6_-_25830557 1.09 ENST00000468082.1
solute carrier family 17 member 1
chr1_+_207104226 1.09 ENST00000367070.8
complement component 4 binding protein alpha
chr16_-_8975320 1.08 ENST00000673704.1
ubiquitin specific peptidase 7
chr3_+_101827982 1.06 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKB inhibitor zeta
chr8_-_94262308 1.04 ENST00000297596.3
ENST00000396194.6
GTP binding protein overexpressed in skeletal muscle
chr18_+_31447732 1.04 ENST00000257189.5
desmoglein 3
chr12_+_75391078 1.03 ENST00000550916.6
ENST00000378692.7
ENST00000320460.8
ENST00000547164.1
GLIPR1 like 2
chr3_+_130850585 1.03 ENST00000505330.5
ENST00000504381.5
ENST00000507488.6
ATPase secretory pathway Ca2+ transporting 1
chr1_-_154627945 1.02 ENST00000681683.1
ENST00000368471.8
ENST00000649042.1
ENST00000680270.1
ENST00000649022.2
ENST00000681056.1
ENST00000649724.1
adenosine deaminase RNA specific
chr7_+_101817601 1.02 ENST00000292535.12
ENST00000546411.7
ENST00000549414.6
ENST00000550008.6
ENST00000556210.1
cut like homeobox 1
chr10_+_94683771 1.00 ENST00000339022.6
cytochrome P450 family 2 subfamily C member 18
chr12_+_53097656 1.00 ENST00000301464.4
insulin like growth factor binding protein 6
chr5_-_59586393 0.99 ENST00000505453.1
ENST00000360047.9
phosphodiesterase 4D
chr8_-_78805515 0.99 ENST00000379113.6
ENST00000541183.2
interleukin 7
chr10_+_60778331 0.98 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
cyclin dependent kinase 1
chr4_+_186227501 0.97 ENST00000446598.6
ENST00000264690.11
ENST00000513864.2
kallikrein B1
chr5_+_31193678 0.97 ENST00000265071.3
cadherin 6
chrX_+_12906639 0.96 ENST00000311912.5
toll like receptor 8
chr6_-_107958165 0.95 ENST00000369002.9
SEC63 homolog, protein translocation regulator
chr6_+_95577465 0.93 ENST00000369293.6
ENST00000683151.1
ENST00000358812.9
mannosidase endo-alpha
chr18_+_616672 0.93 ENST00000338387.11
clusterin like 1
chr1_+_158254414 0.91 ENST00000289429.6
CD1a molecule
chr2_-_164842140 0.91 ENST00000496396.1
ENST00000629362.2
ENST00000445474.2
ENST00000483743.6
cordon-bleu WH2 repeat protein like 1
chr19_-_39391029 0.89 ENST00000221265.8
PAF1 homolog, Paf1/RNA polymerase II complex component
chr5_+_31193739 0.88 ENST00000514738.5
cadherin 6
chr17_-_7916280 0.87 ENST00000324348.9
ring finger protein 227
chr2_-_162152404 0.84 ENST00000375497.3
glucagon
chr16_-_15643024 0.84 ENST00000540441.6
meiosis regulator and mRNA stability factor 1
chr9_-_136439796 0.83 ENST00000676019.1
ENST00000371712.4
inositol polyphosphate-5-phosphatase E
chrX_+_108091752 0.81 ENST00000457035.5
ENST00000372232.8
autophagy related 4A cysteine peptidase
chr15_+_48206286 0.79 ENST00000396577.7
ENST00000380993.8
solute carrier family 12 member 1
chr6_-_26250625 0.77 ENST00000618052.2
H3 clustered histone 7
chr6_+_12717660 0.75 ENST00000674637.1
phosphatase and actin regulator 1
chr6_-_8102481 0.73 ENST00000502429.5
ENST00000429723.6
ENST00000379715.10
ENST00000507463.1
eukaryotic translation elongation factor 1 epsilon 1
chr11_-_13496018 0.73 ENST00000529816.1
parathyroid hormone
chr12_-_130839230 0.72 ENST00000392373.7
ENST00000261653.10
syntaxin 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
3.8 15.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
2.3 29.6 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.6 4.9 GO:0060434 bronchus morphogenesis(GO:0060434)
1.6 4.9 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.4 5.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.2 3.6 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
1.1 4.6 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
1.1 6.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.0 5.1 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
1.0 7.8 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.9 12.8 GO:0001778 plasma membrane repair(GO:0001778)
0.8 10.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.8 2.3 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.7 5.8 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.7 4.3 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.7 4.7 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.6 2.6 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.6 6.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.6 11.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.6 2.4 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.6 2.3 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.5 2.0 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.5 2.5 GO:0090131 mesenchyme migration(GO:0090131)
0.5 1.5 GO:0044565 dendritic cell proliferation(GO:0044565)
0.4 1.3 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.4 1.2 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.4 1.6 GO:0061643 chemorepulsion of dopaminergic neuron axon(GO:0036518) chemorepulsion of axon(GO:0061643)
0.4 2.3 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.4 4.5 GO:0015939 pantothenate metabolic process(GO:0015939)
0.4 2.2 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.4 1.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.4 4.7 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 1.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.3 1.7 GO:2000542 negative regulation of gastrulation(GO:2000542)
0.3 1.3 GO:0051697 protein delipidation(GO:0051697)
0.3 1.9 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.3 1.8 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.3 3.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.3 8.5 GO:0072643 interferon-gamma secretion(GO:0072643)
0.3 7.7 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.3 1.9 GO:0070294 renal sodium ion absorption(GO:0070294)
0.3 1.9 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 1.0 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.3 3.4 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.3 3.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 1.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.3 1.3 GO:0030242 pexophagy(GO:0030242)
0.2 16.5 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 2.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 2.0 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.2 1.8 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.2 0.7 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.2 0.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2 2.0 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 1.3 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.2 3.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.2 1.6 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 1.0 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.2 2.1 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.2 0.9 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.2 1.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 8.8 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
0.2 1.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 1.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 1.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 1.0 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.2 1.0 GO:1900369 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
0.2 0.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 1.7 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.1 17.1 GO:0031295 T cell costimulation(GO:0031295)
0.1 3.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 2.6 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 3.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 1.7 GO:0034378 chylomicron assembly(GO:0034378)
0.1 3.2 GO:0042359 vitamin D metabolic process(GO:0042359)
0.1 2.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.1 GO:1903027 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.1 0.4 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1 0.9 GO:0016584 nucleosome positioning(GO:0016584)
0.1 2.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.4 GO:0022018 subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875)
0.1 2.0 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 0.5 GO:2000317 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.7 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 18.5 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.0 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 4.5 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 2.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.1 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 1.3 GO:0007320 insemination(GO:0007320)
0.1 1.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.1 0.9 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 1.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 7.7 GO:0006953 acute-phase response(GO:0006953)
0.1 10.1 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.9 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.1 4.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.3 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.1 0.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.7 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 3.8 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 5.3 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 3.8 GO:1901998 toxin transport(GO:1901998)
0.1 1.9 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.4 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.1 0.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 5.2 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.1 0.4 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1 5.5 GO:0042100 B cell proliferation(GO:0042100)
0.1 0.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 1.8 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.1 2.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 2.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.9 GO:0033198 response to ATP(GO:0033198)
0.1 1.2 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 6.8 GO:0030449 regulation of complement activation(GO:0030449)
0.1 0.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.1 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.9 GO:0051639 actin filament network formation(GO:0051639)
0.1 2.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 0.4 GO:1901529 positive regulation of anion channel activity(GO:1901529) positive regulation of anion transmembrane transport(GO:1903961)
0.0 0.8 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0 3.4 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349)
0.0 0.6 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.7 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 2.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 1.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 1.0 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0090238 regulation of arachidonic acid secretion(GO:0090237) positive regulation of arachidonic acid secretion(GO:0090238) regulation of store-operated calcium channel activity(GO:1901339)
0.0 0.8 GO:0007143 female meiotic division(GO:0007143)
0.0 0.5 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 3.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 1.4 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 0.1 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.0 2.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.4 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 1.7 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 5.0 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 1.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 1.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 2.7 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.2 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.7 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.0 0.0 GO:0006711 estrogen catabolic process(GO:0006711)
0.0 0.3 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.0 GO:0050893 sensory processing(GO:0050893)
0.0 0.6 GO:0006400 tRNA modification(GO:0006400)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.3 GO:0005826 actomyosin contractile ring(GO:0005826)
1.7 32.1 GO:0042613 MHC class II protein complex(GO:0042613)
1.5 4.6 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
1.2 29.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
1.0 4.9 GO:0031523 Myb complex(GO:0031523)
1.0 5.8 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.8 3.4 GO:0044307 dendritic branch(GO:0044307)
0.8 4.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.8 10.4 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6 1.9 GO:0097414 glial cytoplasmic inclusion(GO:0097409) classical Lewy body(GO:0097414) Lewy neurite(GO:0097462) Lewy body corona(GO:1990038)
0.6 4.5 GO:0072487 MSL complex(GO:0072487)
0.6 1.7 GO:0005588 collagen type V trimer(GO:0005588)
0.6 2.2 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.5 4.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.5 1.5 GO:0034515 proteasome storage granule(GO:0034515)
0.5 6.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.5 5.1 GO:0060171 stereocilium membrane(GO:0060171)
0.4 5.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.4 1.3 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.3 1.3 GO:0000798 nuclear cohesin complex(GO:0000798)
0.3 2.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 3.4 GO:0042555 MCM complex(GO:0042555)
0.2 1.0 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.2 3.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 3.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 1.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 13.8 GO:0001772 immunological synapse(GO:0001772)
0.2 1.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 8.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 1.0 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.1 GO:0000322 storage vacuole(GO:0000322)
0.1 2.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.6 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 2.6 GO:0071141 SMAD protein complex(GO:0071141)
0.1 5.0 GO:0001533 cornified envelope(GO:0001533)
0.1 2.3 GO:0036020 endolysosome membrane(GO:0036020)
0.1 0.6 GO:0005927 muscle tendon junction(GO:0005927)
0.1 10.1 GO:0016459 myosin complex(GO:0016459)
0.1 0.4 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 6.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 11.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.3 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 1.0 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 0.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 12.9 GO:0072562 blood microparticle(GO:0072562)
0.1 0.1 GO:0089701 U2AF(GO:0089701)
0.1 5.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 25.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.1 GO:0008091 spectrin(GO:0008091)
0.1 1.2 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.1 0.7 GO:0005652 nuclear lamina(GO:0005652)
0.1 2.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.0 1.9 GO:0034451 centriolar satellite(GO:0034451)
0.0 23.0 GO:0016607 nuclear speck(GO:0016607)
0.0 1.9 GO:0000791 euchromatin(GO:0000791)
0.0 5.5 GO:0016605 PML body(GO:0016605)
0.0 5.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.0 GO:0051233 spindle midzone(GO:0051233)
0.0 1.3 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0001940 female pronucleus(GO:0001939) male pronucleus(GO:0001940)
0.0 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 2.6 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 4.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.0 0.8 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 4.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.3 GO:0005903 brush border(GO:0005903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
1.3 29.6 GO:0008494 translation activator activity(GO:0008494)
1.1 4.5 GO:0017159 pantetheine hydrolase activity(GO:0017159)
1.0 3.1 GO:1902271 D3 vitamins binding(GO:1902271)
1.0 3.1 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
1.0 4.9 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.8 32.1 GO:0042605 peptide antigen binding(GO:0042605)
0.8 2.4 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.7 5.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.7 16.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.6 1.9 GO:0061609 fructose-1-phosphate aldolase activity(GO:0061609)
0.6 4.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.5 3.9 GO:0004111 creatine kinase activity(GO:0004111)
0.4 1.8 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.4 2.3 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.4 2.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.4 1.9 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.3 10.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3 2.0 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.3 1.9 GO:0035500 MH2 domain binding(GO:0035500)
0.3 1.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.3 1.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 5.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.3 11.3 GO:0000146 microfilament motor activity(GO:0000146)
0.3 1.6 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.3 1.3 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.3 0.8 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.2 1.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 6.3 GO:0031489 myosin V binding(GO:0031489)
0.2 1.6 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.2 5.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 2.6 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.2 7.0 GO:0070717 poly-purine tract binding(GO:0070717)
0.2 3.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.2 2.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 8.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 2.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.2 2.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.5 GO:0031013 troponin I binding(GO:0031013)
0.1 1.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 3.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 2.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 2.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.4 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.1 5.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 1.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 2.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 10.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 2.2 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 1.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1 0.4 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 2.1 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 1.1 GO:0042731 PH domain binding(GO:0042731)
0.1 3.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 3.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 3.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.9 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 16.0 GO:0003823 antigen binding(GO:0003823)
0.1 6.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208)
0.1 3.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.8 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.1 1.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 4.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 2.0 GO:0048018 receptor agonist activity(GO:0048018)
0.1 1.7 GO:0005537 mannose binding(GO:0005537)
0.1 0.7 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 0.7 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.1 3.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.0 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 2.6 GO:0015248 sterol transporter activity(GO:0015248)
0.1 2.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 5.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.3 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 1.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.8 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.1 GO:0032183 SUMO binding(GO:0032183)
0.1 1.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 3.5 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.1 GO:0043531 ADP binding(GO:0043531)
0.0 2.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.7 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 5.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.8 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 1.0 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 2.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 8.8 GO:0001047 core promoter binding(GO:0001047)
0.0 0.1 GO:0035276 ethanol binding(GO:0035276)
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 3.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 14.9 GO:0003682 chromatin binding(GO:0003682)
0.0 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 6.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 5.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 4.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.4 GO:0043621 protein self-association(GO:0043621)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 4.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 39.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.3 3.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 12.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 11.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 4.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 8.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 5.6 PID ALK1 PATHWAY ALK1 signaling events
0.1 5.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 1.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.4 PID ATR PATHWAY ATR signaling pathway
0.1 2.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 3.9 PID TNF PATHWAY TNF receptor signaling pathway
0.1 2.0 PID IL23 PATHWAY IL23-mediated signaling events
0.1 3.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 2.5 PID RHOA PATHWAY RhoA signaling pathway
0.1 2.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.9 PID INSULIN PATHWAY Insulin Pathway
0.1 1.1 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 6.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.7 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 3.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 39.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.8 29.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.4 4.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.3 10.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 4.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 3.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 2.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2 4.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 3.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 5.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 3.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 1.5 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 6.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 4.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 3.8 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 1.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 19.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.6 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.1 2.1 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 6.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.1 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 0.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 1.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 3.6 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 2.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.0 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 4.7 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 3.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.0 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 1.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 4.4 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 1.5 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 1.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides