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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HSF2

Z-value: 1.02

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Transcription factors associated with HSF2

Gene Symbol Gene ID Gene Info
HSF2
ENSG00000025156.13 HSF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HSF2hg38_v1_chr6_+_122399536_122399568,
hg38_v1_chr6_+_122399621_122399692		0.072.8e-01Click!

Activity profile of HSF2 motif

Sorted Z-values of HSF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_76302665 20.50 ENST00000248553.7
ENST00000674638.1
ENST00000674547.1
ENST00000675226.1
ENST00000675538.1
ENST00000676231.1
ENST00000675134.1
ENST00000675906.1
ENST00000674650.1
HSPB1
heat shock protein family B (small) member 1
chr18_-_812230 11.66 ENST00000314574.5
YES1
YES proto-oncogene 1, Src family tyrosine kinase
chr11_-_111910830 9.69 ENST00000526167.5
ENST00000651650.1
CRYAB
crystallin alpha B
chr11_-_111910888 9.67 ENST00000525823.1
ENST00000528961.6
CRYAB
crystallin alpha B
chr6_+_151325665 9.51 ENST00000354675.10
AKAP12
A-kinase anchoring protein 12
chr11_-_111910790 9.50 ENST00000533280.6
CRYAB
crystallin alpha B
chr11_+_75562056 7.72 ENST00000533603.5
SERPINH1
serpin family H member 1
chr12_-_52618559 7.69 ENST00000305748.7
KRT73
keratin 73
chr11_+_75562274 7.67 ENST00000532356.5
ENST00000524558.5
SERPINH1
serpin family H member 1
chr7_+_130486171 7.52 ENST00000341441.9
ENST00000416162.7
MEST
mesoderm specific transcript
chr7_+_130486324 7.50 ENST00000427521.6
ENST00000378576.9
MEST
mesoderm specific transcript
chrX_-_103686687 7.17 ENST00000441076.7
ENST00000422355.5
ENST00000442614.5
ENST00000451301.5
MORF4L2
mortality factor 4 like 2
chrX_+_136197039 6.61 ENST00000370683.6
FHL1
four and a half LIM domains 1
chrX_+_136197020 6.34 ENST00000370676.7
FHL1
four and a half LIM domains 1
chrX_+_136196750 6.29 ENST00000539015.5
FHL1
four and a half LIM domains 1
chr7_+_128830399 6.27 ENST00000325888.13
ENST00000346177.6
FLNC
filamin C
chrX_+_136148440 6.01 ENST00000627383.2
ENST00000630084.2
FHL1
four and a half LIM domains 1
chr5_-_147453888 5.44 ENST00000398514.7
DPYSL3
dihydropyrimidinase like 3
chr18_+_3451647 5.30 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGIF1
TGFB induced factor homeobox 1
chrX_-_103688033 5.29 ENST00000434230.5
ENST00000418819.5
ENST00000360458.5
MORF4L2
mortality factor 4 like 2
chr6_+_31815532 5.15 ENST00000375651.7
ENST00000608703.1
HSPA1A
heat shock protein family A (Hsp70) member 1A
chr10_+_91162958 5.12 ENST00000614189.4
PCGF5
polycomb group ring finger 5
chr18_+_3451585 5.09 ENST00000551541.5
TGIF1
TGFB induced factor homeobox 1
chrX_-_103688090 5.08 ENST00000433176.6
MORF4L2
mortality factor 4 like 2
chr2_+_197500371 5.07 ENST00000409468.1
ENST00000233893.10
HSPE1
heat shock protein family E (Hsp10) member 1
chr14_-_52069228 5.00 ENST00000617139.4
NID2
nidogen 2
chr8_-_140921188 4.95 ENST00000517887.5
PTK2
protein tyrosine kinase 2
chr3_+_159069252 4.77 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr15_+_96325935 4.59 ENST00000421109.6
NR2F2
nuclear receptor subfamily 2 group F member 2
chr9_+_33025265 4.58 ENST00000330899.5
DNAJA1
DnaJ heat shock protein family (Hsp40) member A1
chr12_+_69585434 4.40 ENST00000299300.11
ENST00000544368.6
CCT2
chaperonin containing TCP1 subunit 2
chr14_-_52069039 4.33 ENST00000216286.10
NID2
nidogen 2
chr2_+_197500398 4.29 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr11_-_83285965 4.22 ENST00000529073.5
ENST00000529611.5
CCDC90B
coiled-coil domain containing 90B
chr2_-_197499857 4.13 ENST00000428204.6
ENST00000678170.1
ENST00000676933.1
ENST00000678621.1
HSPD1
heat shock protein family D (Hsp60) member 1
chr7_-_80919017 4.01 ENST00000265361.8
SEMA3C
semaphorin 3C
chr2_-_197499826 3.86 ENST00000439605.2
ENST00000388968.8
ENST00000418022.2
HSPD1
heat shock protein family D (Hsp60) member 1
chr16_+_715092 3.86 ENST00000568223.7
METRN
meteorin, glial cell differentiation regulator
chr12_+_119178953 3.82 ENST00000674542.1
HSPB8
heat shock protein family B (small) member 8
chr2_-_187554351 3.78 ENST00000437725.5
ENST00000409676.5
ENST00000233156.9
ENST00000339091.8
ENST00000420747.1
TFPI
tissue factor pathway inhibitor
chr2_-_177263522 3.75 ENST00000448782.5
ENST00000446151.6
NFE2L2
nuclear factor, erythroid 2 like 2
chr12_+_69585666 3.67 ENST00000543146.2
CCT2
chaperonin containing TCP1 subunit 2
chr12_+_119178920 3.65 ENST00000281938.7
HSPB8
heat shock protein family B (small) member 8
chr19_-_14518383 3.64 ENST00000254322.3
ENST00000595139.2
DNAJB1
DnaJ heat shock protein family (Hsp40) member B1
chr8_+_133113483 3.62 ENST00000521107.1
TG
thyroglobulin
chr9_+_89311187 3.58 ENST00000314355.7
CKS2
CDC28 protein kinase regulatory subunit 2
chr5_-_73448769 3.58 ENST00000615637.3
FOXD1
forkhead box D1
chr9_-_33025052 3.56 ENST00000673248.1
APTX
aprataxin
chr14_-_102087034 3.53 ENST00000216281.13
ENST00000553585.5
HSP90AA1
heat shock protein 90 alpha family class A member 1
chr11_-_27722021 3.46 ENST00000314915.6
BDNF
brain derived neurotrophic factor
chr6_+_31827730 3.31 ENST00000375650.5
HSPA1B
heat shock protein family A (Hsp70) member 1B
chr15_+_42359577 3.18 ENST00000357568.8
CAPN3
calpain 3
chr11_-_83286328 3.10 ENST00000525503.5
CCDC90B
coiled-coil domain containing 90B
chr11_-_83286377 3.09 ENST00000455220.6
ENST00000529689.5
CCDC90B
coiled-coil domain containing 90B
chr9_-_86100123 3.02 ENST00000388711.7
ENST00000466178.1
GOLM1
golgi membrane protein 1
chr7_+_157336961 2.92 ENST00000429029.6
DNAJB6
DnaJ heat shock protein family (Hsp40) member B6
chr2_-_10837977 2.83 ENST00000404824.2
PDIA6
protein disulfide isomerase family A member 6
chr10_-_99913971 2.67 ENST00000543621.6
DNMBP
dynamin binding protein
chr3_+_172040554 2.63 ENST00000336824.8
ENST00000423424.5
FNDC3B
fibronectin type III domain containing 3B
chr7_+_157336988 2.56 ENST00000262177.9
ENST00000417758.5
ENST00000443280.5
DNAJB6
DnaJ heat shock protein family (Hsp40) member B6
chrX_-_153724343 2.56 ENST00000442093.5
ENST00000345046.12
ENST00000645377.1
ENST00000672675.1
ENST00000647529.1
ENST00000429550.5
BCAP31
B cell receptor associated protein 31
chr11_-_123062335 2.48 ENST00000453788.6
ENST00000527387.5
HSPA8
heat shock protein family A (Hsp70) member 8
chr14_+_88594406 2.48 ENST00000555900.5
ZC3H14
zinc finger CCCH-type containing 14
chrX_-_153724044 2.47 ENST00000423827.5
ENST00000458587.8
BCAP31
B cell receptor associated protein 31
chr11_+_66002754 2.47 ENST00000527348.1
BANF1
BAF nuclear assembly factor 1
chr14_+_88594430 2.38 ENST00000406216.7
ENST00000557737.1
ZC3H14
zinc finger CCCH-type containing 14
chr11_-_65557740 2.27 ENST00000526927.5
LTBP3
latent transforming growth factor beta binding protein 3
chr11_-_90223036 2.25 ENST00000320585.11
CHORDC1
cysteine and histidine rich domain containing 1
chr2_-_216695540 2.24 ENST00000233813.5
IGFBP5
insulin like growth factor binding protein 5
chr20_+_4686320 2.11 ENST00000430350.2
PRNP
prion protein
chr14_+_88594395 2.10 ENST00000318308.10
ZC3H14
zinc finger CCCH-type containing 14
chr9_-_33025088 2.07 ENST00000436040.7
APTX
aprataxin
chr11_-_90223059 2.07 ENST00000457199.6
ENST00000530765.5
CHORDC1
cysteine and histidine rich domain containing 1
chr13_-_31161927 2.05 ENST00000380405.7
HSPH1
heat shock protein family H (Hsp110) member 1
chr21_+_34073569 1.99 ENST00000399312.3
ENST00000381151.5
ENST00000362077.4
MRPS6
SLC5A3
ENSG00000272657.1
mitochondrial ribosomal protein S6
solute carrier family 5 member 3
novel transcript
chr20_+_31547367 1.93 ENST00000394552.3
MCTS2P
MCTS family member 2, pseudogene
chr4_-_158723355 1.80 ENST00000307720.4
PPID
peptidylprolyl isomerase D
chr11_+_27040725 1.79 ENST00000529202.5
ENST00000263182.8
BBOX1
gamma-butyrobetaine hydroxylase 1
chr6_-_22297028 1.73 ENST00000306482.2
PRL
prolactin
chr7_-_26200734 1.69 ENST00000354667.8
ENST00000618183.5
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr11_+_66002225 1.67 ENST00000445560.6
ENST00000530204.1
BANF1
BAF nuclear assembly factor 1
chr3_-_48595267 1.63 ENST00000328333.12
ENST00000681320.1
COL7A1
collagen type VII alpha 1 chain
chr3_-_15797930 1.59 ENST00000683139.1
ANKRD28
ankyrin repeat domain 28
chr2_-_187554473 1.57 ENST00000453013.5
ENST00000417013.5
TFPI
tissue factor pathway inhibitor
chr12_+_2794961 1.56 ENST00000001008.6
FKBP4
FKBP prolyl isomerase 4
chr13_-_31161890 1.54 ENST00000320027.10
HSPH1
heat shock protein family H (Hsp110) member 1
chr18_+_24139013 1.52 ENST00000399481.6
ENST00000327201.10
CABYR
calcium binding tyrosine phosphorylation regulated
chr11_-_123062022 1.52 ENST00000532182.5
ENST00000524590.5
ENST00000528292.5
ENST00000533540.5
ENST00000534624.6
ENST00000525463.5
HSPA8
heat shock protein family A (Hsp70) member 8
chr11_+_86302211 1.49 ENST00000533986.5
ENST00000278483.8
HIKESHI
heat shock protein nuclear import factor hikeshi
chr3_+_45026296 1.39 ENST00000296130.5
CLEC3B
C-type lectin domain family 3 member B
chr11_+_66002475 1.37 ENST00000312175.7
ENST00000533166.5
BANF1
BAF nuclear assembly factor 1
chr4_-_152679984 1.37 ENST00000304385.8
ENST00000504064.1
TMEM154
transmembrane protein 154
chr6_+_44247866 1.36 ENST00000371554.2
HSP90AB1
heat shock protein 90 alpha family class B member 1
chr3_-_15798184 1.34 ENST00000624145.3
ANKRD28
ankyrin repeat domain 28
chr8_-_80171106 1.25 ENST00000519303.6
TPD52
tumor protein D52
chr10_-_103153609 1.24 ENST00000675985.1
NT5C2
5'-nucleotidase, cytosolic II
chr15_-_58065703 1.24 ENST00000249750.9
ALDH1A2
aldehyde dehydrogenase 1 family member A2
chr13_-_31162341 1.23 ENST00000445273.6
ENST00000630972.2
HSPH1
heat shock protein family H (Hsp110) member 1
chr1_+_151198536 1.21 ENST00000349792.9
ENST00000409426.5
ENST00000368888.9
ENST00000441902.6
ENST00000368890.8
ENST00000424999.1
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
chr16_+_71358713 1.20 ENST00000349553.9
ENST00000302628.9
ENST00000562305.5
CALB2
calbindin 2
chr6_+_32154131 1.19 ENST00000375143.6
ENST00000324816.11
ENST00000424499.1
PPT2
palmitoyl-protein thioesterase 2
chr11_+_59511368 1.17 ENST00000641278.1
OR4D9
olfactory receptor family 4 subfamily D member 9
chrX_-_119606412 1.14 ENST00000304449.8
NKRF
NFKB repressing factor
chr11_+_66509079 1.14 ENST00000419755.3
ENSG00000256349.1
novel protein
chr4_-_73223082 1.11 ENST00000509867.6
ANKRD17
ankyrin repeat domain 17
chr6_+_32154010 1.09 ENST00000375137.6
PPT2
palmitoyl-protein thioesterase 2
chr9_+_841691 1.06 ENST00000382276.8
DMRT1
doublesex and mab-3 related transcription factor 1
chr3_-_15440560 1.06 ENST00000595627.5
ENST00000597949.1
ENST00000494875.3
ENST00000595975.1
ENST00000598878.1
EAF1-AS1
METTL6
EAF1 antisense RNA 1
methyltransferase like 6
chr1_-_6393750 1.04 ENST00000545482.5
ENST00000361521.9
ACOT7
acyl-CoA thioesterase 7
chr11_+_12674397 1.02 ENST00000527636.7
TEAD1
TEA domain transcription factor 1
chr4_+_76011171 0.97 ENST00000513353.5
ENST00000341029.9
ART3
ADP-ribosyltransferase 3 (inactive)
chr9_-_13279407 0.96 ENST00000546205.5
MPDZ
multiple PDZ domain crumbs cell polarity complex component
chr2_-_85354500 0.87 ENST00000449375.1
ENST00000409984.2
ENST00000295802.9
RETSAT
retinol saturase
chr2_-_96740034 0.82 ENST00000264963.9
ENST00000377079.8
LMAN2L
lectin, mannose binding 2 like
chr1_-_120176450 0.81 ENST00000578049.4
SEC22B
SEC22 homolog B, vesicle trafficking protein
chr15_-_43493105 0.79 ENST00000382039.7
ENST00000450115.6
ENST00000382044.9
TP53BP1
tumor protein p53 binding protein 1
chr6_+_146543824 0.79 ENST00000367495.4
RAB32
RAB32, member RAS oncogene family
chr6_+_32153441 0.77 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
PPT2
palmitoyl-protein thioesterase 2
chr11_+_59511539 0.76 ENST00000641962.1
OR4D9
olfactory receptor family 4 subfamily D member 9
chr21_-_29073565 0.75 ENST00000431234.1
ENST00000286788.9
ENST00000540844.5
CCT8
chaperonin containing TCP1 subunit 8
chr5_+_80035341 0.72 ENST00000350881.6
THBS4
thrombospondin 4
chr17_-_58417521 0.71 ENST00000584437.5
ENST00000407977.7
RNF43
ring finger protein 43
chr11_+_72080803 0.67 ENST00000423494.6
ENST00000539587.6
ENST00000536917.2
ENST00000538478.5
ENST00000324866.11
ENST00000643715.1
ENST00000439209.5
LRTOMT
ENSG00000284922.2
leucine rich transmembrane and O-methyltransferase domain containing
leucine rich transmembrane and O-methyltransferase domain containing
chr11_+_72080595 0.66 ENST00000647530.1
ENST00000539271.6
ENST00000642510.1
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
chr9_-_34710069 0.66 ENST00000378792.1
ENST00000259607.7
CCL21
C-C motif chemokine ligand 21
chr1_-_168729187 0.66 ENST00000367817.4
DPT
dermatopontin
chr1_-_6393339 0.65 ENST00000608083.5
ACOT7
acyl-CoA thioesterase 7
chr6_-_53148822 0.65 ENST00000259803.8
GCM1
glial cells missing transcription factor 1
chr20_+_63235899 0.60 ENST00000217169.8
BIRC7
baculoviral IAP repeat containing 7
chr8_+_109540075 0.59 ENST00000614147.1
ENST00000337573.10
EBAG9
estrogen receptor binding site associated antigen 9
chr4_-_107036302 0.58 ENST00000285311.8
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr6_-_155314444 0.51 ENST00000367166.5
TFB1M
transcription factor B1, mitochondrial
chr17_-_58417547 0.50 ENST00000577716.5
RNF43
ring finger protein 43
chr6_-_32371872 0.47 ENST00000527965.5
ENST00000532023.5
ENST00000447241.6
ENST00000534588.1
TSBP1
testis expressed basic protein 1
chr13_+_49110309 0.44 ENST00000398316.7
FNDC3A
fibronectin type III domain containing 3A
chr8_-_119592954 0.43 ENST00000522167.5
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr20_+_46118300 0.43 ENST00000372285.8
ENST00000372276.7
CD40
CD40 molecule
chr1_-_197775435 0.38 ENST00000620048.6
DENND1B
DENN domain containing 1B
chrX_-_19965142 0.38 ENST00000340625.3
BCLAF3
BCLAF1 and THRAP3 family member 3
chr7_-_42152396 0.35 ENST00000642432.1
ENST00000647255.1
ENST00000677288.1
GLI3
GLI family zinc finger 3
chr2_-_218286763 0.34 ENST00000444881.5
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr3_+_14947568 0.31 ENST00000413118.5
ENST00000425241.5
NR2C2
nuclear receptor subfamily 2 group C member 2
chr6_-_142946312 0.28 ENST00000367604.6
HIVEP2
HIVEP zinc finger 2
chr18_-_46917432 0.25 ENST00000324794.11
ENST00000545673.5
ENST00000585916.6
PIAS2
protein inhibitor of activated STAT 2
chr7_-_42152444 0.23 ENST00000479210.1
GLI3
GLI family zinc finger 3
chr6_-_32371912 0.20 ENST00000612031.4
TSBP1
testis expressed basic protein 1
chr5_-_149063021 0.18 ENST00000515425.6
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr6_-_32371897 0.17 ENST00000442822.6
ENST00000375015.8
ENST00000533191.5
TSBP1
testis expressed basic protein 1
chr6_+_29396555 0.16 ENST00000623183.1
OR12D2
olfactory receptor family 12 subfamily D member 2
chr8_-_80171496 0.16 ENST00000379096.9
ENST00000518937.6
TPD52
tumor protein D52
chr6_-_135054785 0.15 ENST00000367820.6
ENST00000314674.7
ENST00000524715.5
ENST00000415177.6
ENST00000367826.6
ENST00000367837.10
HBS1L
HBS1 like translational GTPase
chr17_-_41505597 0.14 ENST00000336861.7
ENST00000246635.8
ENST00000587544.5
ENST00000587435.1
KRT13
keratin 13
chr3_-_129688691 0.13 ENST00000432054.6
TMCC1
transmembrane and coiled-coil domain family 1
chr2_+_11542662 0.11 ENST00000389825.7
ENST00000381483.6
GREB1
growth regulating estrogen receptor binding 1
chr1_+_26921715 0.09 ENST00000321265.10
NUDC
nuclear distribution C, dynein complex regulator
chr20_+_63235883 0.07 ENST00000342412.10
BIRC7
baculoviral IAP repeat containing 7
chr1_-_184037695 0.05 ENST00000361927.9
ENST00000649786.1
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr6_-_109094819 0.03 ENST00000436639.6
SESN1
sestrin 1
chr5_-_22853320 0.00 ENST00000504376.6
ENST00000382254.6
CDH12
cadherin 12

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 20.5 GO:0099640 axo-dendritic protein transport(GO:0099640)
2.7 8.0 GO:0002368 B cell cytokine production(GO:0002368)
2.1 8.5 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
1.9 15.4 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
1.7 28.9 GO:0007021 tubulin complex assembly(GO:0007021)
1.6 8.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
1.4 4.3 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
1.3 5.0 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
1.2 3.5 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
1.1 4.6 GO:0009956 radial pattern formation(GO:0009956)
1.0 9.4 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.9 3.8 GO:1901377 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.9 3.5 GO:0043335 protein unfolding(GO:0043335)
0.8 4.0 GO:1902904 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.8 9.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.8 2.3 GO:1902462 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.7 2.2 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.7 3.6 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.7 5.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.7 4.0 GO:0003350 pulmonary myocardium development(GO:0003350)
0.7 2.0 GO:0015798 myo-inositol transport(GO:0015798)
0.6 17.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.6 5.3 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.6 5.6 GO:0000012 single strand break repair(GO:0000012)
0.5 8.7 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.5 2.1 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535)
0.5 3.6 GO:0015705 iodide transport(GO:0015705)
0.5 1.4 GO:0036363 transforming growth factor beta activation(GO:0036363) regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
0.4 7.0 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.4 1.7 GO:0036114 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.4 11.7 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.4 1.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.4 5.5 GO:0015074 DNA integration(GO:0015074)
0.4 1.1 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.4 3.2 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.4 4.9 GO:0051964 netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964)
0.3 24.3 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.3 3.0 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.3 9.3 GO:0071711 basement membrane organization(GO:0071711)
0.2 1.7 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 0.7 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.2 5.4 GO:0051764 actin crosslink formation(GO:0051764)
0.2 1.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.2 0.7 GO:0097026 mesangial cell-matrix adhesion(GO:0035759) dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547)
0.2 0.6 GO:0060018 astrocyte fate commitment(GO:0060018)
0.2 1.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 0.6 GO:0060366 subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875)
0.2 1.8 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.4 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 1.2 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.8 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 9.8 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 6.3 GO:0048747 muscle fiber development(GO:0048747)
0.1 0.8 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280) negative regulation of autophagosome assembly(GO:1902902) vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane(GO:1990668)
0.1 3.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 15.0 GO:0007498 mesoderm development(GO:0007498)
0.1 0.7 GO:1903405 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867)
0.1 1.5 GO:0003351 epithelial cilium movement(GO:0003351)
0.1 1.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 1.3 GO:0060117 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) auditory receptor cell development(GO:0060117)
0.1 0.3 GO:1902044 regulation of Fas signaling pathway(GO:1902044) positive regulation of blood vessel remodeling(GO:2000504)
0.1 7.8 GO:0070268 cornification(GO:0070268)
0.1 4.6 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.7 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.7 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.9 GO:0042572 retinol metabolic process(GO:0042572)
0.0 1.0 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 3.9 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 2.8 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.2 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.3 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 1.0 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.4 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.5 GO:0031167 rRNA methylation(GO:0031167)
0.0 2.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.4 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 28.9 GO:0097512 cardiac myofibril(GO:0097512)
0.9 8.0 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) lipopolysaccharide receptor complex(GO:0046696)
0.8 5.0 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.6 8.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.5 17.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.5 1.5 GO:0097229 sperm end piece(GO:0097229)
0.5 4.0 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.5 4.6 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.5 1.4 GO:1990913 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
0.3 1.0 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.3 20.5 GO:1904115 axon cytoplasm(GO:1904115)
0.3 7.7 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.3 2.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 1.4 GO:0001652 granular component(GO:0001652)
0.2 2.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 7.8 GO:0045095 keratin filament(GO:0045095)
0.2 8.5 GO:0016235 aggresome(GO:0016235)
0.2 2.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 0.8 GO:0031905 early endosome lumen(GO:0031905)
0.1 17.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 6.3 GO:0043034 costamere(GO:0043034)
0.1 5.2 GO:0031941 filamentous actin(GO:0031941)
0.1 1.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 5.1 GO:0031519 PcG protein complex(GO:0031519)
0.1 1.6 GO:0044295 axonal growth cone(GO:0044295)
0.1 9.2 GO:0005604 basement membrane(GO:0005604)
0.1 2.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 46.0 GO:0005925 focal adhesion(GO:0005925)
0.1 8.7 GO:0030018 Z disc(GO:0030018)
0.1 1.0 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 1.2 GO:0005921 gap junction(GO:0005921)
0.0 5.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.3 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 3.0 GO:0043202 lysosomal lumen(GO:0043202)
0.0 11.6 GO:0016607 nuclear speck(GO:0016607)
0.0 1.0 GO:0031904 endosome lumen(GO:0031904)
0.0 3.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.8 GO:0005795 Golgi stack(GO:0005795)
0.0 3.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 20.5 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
1.9 5.6 GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity(GO:0033699)
1.5 16.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
1.3 8.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
1.0 28.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.9 3.5 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.6 3.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.6 1.8 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.5 5.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.5 9.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.5 1.4 GO:0002135 CTP binding(GO:0002135)
0.4 1.7 GO:0005148 prolactin receptor binding(GO:0005148)
0.4 2.1 GO:1903135 cupric ion binding(GO:1903135)
0.4 1.2 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.4 1.2 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.4 3.5 GO:0030911 TPR domain binding(GO:0030911)
0.4 1.6 GO:0032767 copper-dependent protein binding(GO:0032767)
0.4 4.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 10.4 GO:0070410 co-SMAD binding(GO:0070410)
0.3 2.0 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.3 36.3 GO:0051082 unfolded protein binding(GO:0051082)
0.3 3.0 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.3 0.8 GO:0035650 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.3 4.9 GO:0008432 JUN kinase binding(GO:0008432)
0.2 4.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 6.3 GO:0030506 ankyrin binding(GO:0030506)
0.2 1.0 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.2 11.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 1.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 3.2 GO:0031432 titin binding(GO:0031432)
0.2 2.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 7.0 GO:0008143 poly(A) binding(GO:0008143)
0.2 5.0 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 0.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 2.8 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 1.7 GO:0097157 pre-mRNA intronic binding(GO:0097157) N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 4.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.2 GO:0016918 retinal binding(GO:0016918)
0.1 1.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.4 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 23.9 GO:0044325 ion channel binding(GO:0044325)
0.1 3.6 GO:0008301 DNA binding, bending(GO:0008301)
0.1 4.8 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 0.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 4.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 8.7 GO:0005518 collagen binding(GO:0005518)
0.1 7.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.6 GO:0039706 co-receptor binding(GO:0039706)
0.0 1.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.8 GO:0005537 mannose binding(GO:0005537)
0.0 1.2 GO:0005109 frizzled binding(GO:0005109)
0.0 5.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 3.6 GO:0005179 hormone activity(GO:0005179)
0.0 2.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.9 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.0 0.9 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 20.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 11.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.2 8.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 8.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.2 10.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 3.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 6.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 11.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 1.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 4.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 4.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 15.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 3.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 5.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID ATM PATHWAY ATM pathway
0.0 4.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.7 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.5 5.5 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.3 27.8 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.3 8.8 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3 4.9 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.3 17.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 4.9 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 5.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 10.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 8.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.3 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1 2.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 5.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 4.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines