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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRF2_STAT2_IRF8_IRF1

Z-value: 0.43

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Transcription factors associated with IRF2_STAT2_IRF8_IRF1

Gene Symbol Gene ID Gene Info
ENSG00000168310.11 IRF2
ENSG00000170581.14 STAT2
ENSG00000140968.11 IRF8
ENSG00000125347.15 IRF1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF1hg38_v1_chr5_-_132490750_1324908400.809.7e-50Click!
IRF2hg38_v1_chr4_-_184474518_1844745560.711.9e-34Click!
IRF8hg38_v1_chr16_+_85908988_859090330.611.7e-23Click!
STAT2hg38_v1_chr12_-_56360084_563601460.136.1e-02Click!

Activity profile of IRF2_STAT2_IRF8_IRF1 motif

Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF2_STAT2_IRF8_IRF1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_+_32854179 186.54 ENST00000374859.3
proteasome 20S subunit beta 9
chr1_+_1013485 151.93 ENST00000649529.1
ISG15 ubiquitin like modifier
chr2_-_151289613 140.19 ENST00000243346.10
N-myc and STAT interactor
chr11_-_615921 131.75 ENST00000348655.11
ENST00000525445.6
ENST00000330243.9
interferon regulatory factor 7
chr16_-_67936808 124.19 ENST00000358514.9
proteasome 20S subunit beta 10
chr6_+_32844108 113.81 ENST00000458296.2
ENST00000413039.6
ENST00000412095.1
ENST00000395330.5
PSMB8 antisense RNA 1 (head to head)
proteasome 20S subunit beta 9
chr21_+_41361999 112.99 ENST00000436410.5
ENST00000435611.6
ENST00000330714.8
MX dynamin like GTPase 2
chr6_-_32843994 106.79 ENST00000395339.7
ENST00000374882.8
proteasome 20S subunit beta 8
chr12_+_112978386 95.05 ENST00000342315.8
2'-5'-oligoadenylate synthetase 2
chr6_-_33314055 94.81 ENST00000434618.7
TAP binding protein
chr19_+_1077394 94.30 ENST00000590577.2
Rho GTPase activating protein 45
chr19_-_17405554 94.17 ENST00000252593.7
bone marrow stromal cell antigen 2
chr11_-_615570 93.79 ENST00000649187.1
ENST00000647801.1
ENST00000397566.5
ENST00000397570.5
interferon regulatory factor 7
chr1_+_174874434 93.70 ENST00000478442.5
ENST00000465412.5
RAB GTPase activating protein 1 like
chr1_+_159010002 93.69 ENST00000359709.7
interferon gamma inducible protein 16
chr1_+_159009886 90.84 ENST00000340979.10
ENST00000368131.8
ENST00000295809.12
ENST00000368132.7
interferon gamma inducible protein 16
chr13_+_49496355 88.73 ENST00000496612.5
ENST00000357596.7
ENST00000485919.5
ENST00000442195.5
PHD finger protein 11
chr11_+_5689780 86.21 ENST00000379965.8
ENST00000454828.5
tripartite motif containing 22
chr13_+_49495941 85.86 ENST00000378319.8
ENST00000496623.5
ENST00000426879.5
PHD finger protein 11
chr6_-_32853618 81.72 ENST00000354258.5
transporter 1, ATP binding cassette subfamily B member
chr7_+_74773962 80.45 ENST00000289473.10
neutrophil cytosolic factor 1
chr6_-_32853813 79.74 ENST00000643049.2
transporter 1, ATP binding cassette subfamily B member
chr21_+_41420515 75.88 ENST00000398600.6
ENST00000679626.1
MX dynamin like GTPase 1
chr7_-_140062841 75.42 ENST00000263549.8
poly(ADP-ribose) polymerase family member 12
chr6_+_26365215 74.03 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr1_+_78649818 72.73 ENST00000370747.9
ENST00000438486.1
interferon induced protein 44
chr6_+_26365176 72.33 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr2_-_230219944 70.78 ENST00000455674.2
ENST00000392048.7
ENST00000258381.11
ENST00000358662.9
ENST00000258382.10
SP110 nuclear body protein
chr10_-_89414458 68.44 ENST00000371837.5
lipase A, lysosomal acid type
chr6_+_26365159 67.69 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
butyrophilin subfamily 3 member A2
chr15_+_88639009 65.56 ENST00000306072.10
interferon stimulated exonuclease gene 20
chr19_-_46714269 63.31 ENST00000600194.5
protein kinase D2
chr21_+_41426590 62.25 ENST00000679543.1
ENST00000680364.1
MX dynamin like GTPase 1
chr3_-_49813880 61.10 ENST00000333486.4
ubiquitin like modifier activating enzyme 7
chr2_+_201116793 60.76 ENST00000441224.5
CASP8 and FADD like apoptosis regulator
chr2_-_230219902 60.23 ENST00000409815.6
SP110 nuclear body protein
chr21_+_41426031 60.13 ENST00000455164.6
ENST00000681849.1
ENST00000679705.1
ENST00000424365.6
MX dynamin like GTPase 1
chr15_+_44711487 59.02 ENST00000544417.5
ENST00000559916.1
ENST00000648006.3
beta-2-microglobulin
chr12_+_25052512 58.20 ENST00000557489.5
ENST00000354454.7
ENST00000536173.5
inositol 1,4,5-triphosphate receptor associated 2
chr11_-_60952067 56.92 ENST00000681275.1
solute carrier family 15 member 3
chr1_+_12166978 55.77 ENST00000376259.7
ENST00000536782.2
TNF receptor superfamily member 1B
chr11_-_57567617 54.04 ENST00000287156.9
ubiquitin conjugating enzyme E2 L6
chr22_-_17219571 53.72 ENST00000610390.4
adenosine deaminase 2
chr12_-_48925483 53.57 ENST00000550765.6
ENST00000552878.5
ENST00000453172.2
FKBP prolyl isomerase 11
chr1_+_78620722 52.84 ENST00000679848.1
interferon induced protein 44 like
chr14_+_24136152 51.87 ENST00000559123.5
ENST00000206451.11
ENST00000382708.7
ENST00000561435.5
proteasome activator subunit 1
chr12_-_48924919 51.76 ENST00000444214.6
FKBP prolyl isomerase 11
chr11_-_105035113 51.26 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
caspase 1
chr4_+_146175702 50.83 ENST00000296581.11
ENST00000649747.1
ENST00000502781.5
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
chr16_-_88785210 49.39 ENST00000301015.14
piezo type mechanosensitive ion channel component 1
chr11_-_60952134 49.12 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
solute carrier family 15 member 3
chr22_-_17219424 48.96 ENST00000649540.1
ENST00000399837.8
ENST00000543038.1
adenosine deaminase 2
chr17_-_20467535 48.82 ENST00000324290.5
ENST00000423676.8
galectin 9B
chr17_+_27631148 48.60 ENST00000313648.10
ENST00000395473.7
ENST00000577392.5
ENST00000584661.5
galectin 9
chr22_+_39077264 48.15 ENST00000407997.4
apolipoprotein B mRNA editing enzyme catalytic subunit 3G
chr15_+_88638947 47.65 ENST00000559876.2
interferon stimulated exonuclease gene 20
chr16_-_31202733 47.47 ENST00000350605.4
ENST00000247470.10
PYD and CARD domain containing
chr19_+_18173804 46.79 ENST00000407280.4
IFI30 lysosomal thiol reductase
chr11_-_60952559 46.75 ENST00000538739.2
solute carrier family 15 member 3
chr6_+_6588708 46.64 ENST00000230568.5
lymphocyte antigen 86
chr17_+_42289213 45.53 ENST00000677301.1
signal transducer and activator of transcription 5A
chr11_+_314010 45.17 ENST00000680699.1
ENST00000681938.1
ENST00000679380.1
ENST00000680938.1
ENST00000408968.4
ENST00000681180.1
ENST00000681426.1
ENST00000680696.1
interferon induced transmembrane protein 1
chr1_+_179082025 44.46 ENST00000367625.8
ENST00000367627.8
ENST00000352445.10
torsin family 3 member A
chr4_-_184474518 44.05 ENST00000393593.8
interferon regulatory factor 2
chr6_+_26440472 43.62 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
butyrophilin subfamily 3 member A3
chr12_+_112978504 42.95 ENST00000392583.7
2'-5'-oligoadenylate synthetase 2
chr3_-_49104745 42.79 ENST00000635194.1
ENST00000306125.12
ENST00000634602.1
ENST00000414533.5
ENST00000635443.1
ENST00000452739.5
ENST00000635231.1
glutaminyl-tRNA synthetase 1
chr12_+_112978562 42.51 ENST00000680122.1
2'-5'-oligoadenylate synthetase 2
chr1_-_111204343 42.01 ENST00000369752.5
DENN domain containing 2D
chr14_+_58244821 41.90 ENST00000216455.9
ENST00000412908.6
ENST00000557508.5
proteasome 20S subunit alpha 3
chr1_+_78620432 41.79 ENST00000370751.10
ENST00000459784.6
ENST00000680110.1
ENST00000680295.1
interferon induced protein 44 like
chr10_+_89327977 41.65 ENST00000681277.1
interferon induced protein with tetratricopeptide repeats 3
chrX_+_37780049 41.46 ENST00000378588.5
cytochrome b-245 beta chain
chr3_-_146544701 41.15 ENST00000487389.5
phospholipid scramblase 1
chr14_-_100375333 40.58 ENST00000557297.5
ENST00000555813.5
ENST00000392882.7
ENST00000557135.5
ENST00000556698.5
ENST00000554509.5
ENST00000555410.5
tryptophanyl-tRNA synthetase 1
chr10_+_89327989 40.45 ENST00000679923.1
ENST00000680085.1
ENST00000371818.9
ENST00000680779.1
interferon induced protein with tetratricopeptide repeats 3
chr3_-_172523460 40.09 ENST00000420541.6
TNF superfamily member 10
chr21_+_41426197 40.05 ENST00000680942.1
ENST00000288383.11
ENST00000679386.1
MX dynamin like GTPase 1
chr2_+_201116396 39.44 ENST00000395148.6
CASP8 and FADD like apoptosis regulator
chr1_+_158831323 38.04 ENST00000368141.5
myeloid cell nuclear differentiation antigen
chr17_+_48831021 38.02 ENST00000509507.5
ENST00000448105.6
ENST00000570513.5
ENST00000509415.5
ENST00000513119.5
ENST00000416445.6
ENST00000508679.5
ENST00000258947.8
ENST00000505071.5
calcium binding and coiled-coil domain 2
chr1_-_154608140 37.68 ENST00000529168.2
ENST00000368474.9
ENST00000680305.1
ENST00000648231.2
adenosine deaminase RNA specific
chr14_-_100375602 37.29 ENST00000553395.5
ENST00000553545.5
ENST00000344102.9
ENST00000556338.5
ENST00000553934.1
tryptophanyl-tRNA synthetase 1
chr3_-_49104457 36.34 ENST00000635292.1
ENST00000635541.1
ENST00000464962.6
glutaminyl-tRNA synthetase 1
chr21_+_41426168 35.76 ENST00000681266.1
ENST00000417963.6
MX dynamin like GTPase 1
chr1_-_89065200 35.68 ENST00000370473.5
guanylate binding protein 1
chr12_-_9869345 34.26 ENST00000228438.3
C-type lectin domain family 2 member B
chrX_+_123961696 34.10 ENST00000371145.8
ENST00000371157.7
ENST00000371144.7
stromal antigen 2
chr11_+_63536801 33.71 ENST00000255688.8
ENST00000439013.6
phospholipase A and acyltransferase 4
chr3_-_146544636 32.65 ENST00000486631.5
phospholipid scramblase 1
chr19_+_13151975 32.59 ENST00000588173.1
immediate early response 2
chr8_+_143558329 32.17 ENST00000262580.9
ENST00000525721.1
ENST00000534018.5
gasdermin D
chr1_-_151347234 32.13 ENST00000290524.8
ENST00000452671.7
ENST00000437327.5
ENST00000368870.6
regulatory factor X5
chr16_+_11965193 32.11 ENST00000053243.6
ENST00000396495.3
TNF receptor superfamily member 17
chr12_+_94148553 32.07 ENST00000258526.9
plexin C1
chr20_+_408030 31.72 ENST00000640614.1
ENST00000475269.5
RANBP2-type and C3HC4-type zinc finger containing 1
chr3_-_172523423 31.52 ENST00000241261.7
TNF superfamily member 10
chr21_+_41426289 31.40 ENST00000679408.1
ENST00000681039.1
ENST00000681671.1
MX dynamin like GTPase 1
chr19_+_10086305 31.08 ENST00000253110.16
ENST00000591813.5
shiftless antiviral inhibitor of ribosomal frameshifting
chr12_+_25052732 30.89 ENST00000547044.5
inositol 1,4,5-triphosphate receptor associated 2
chr2_-_162318129 30.53 ENST00000679938.1
interferon induced with helicase C domain 1
chr11_+_1853049 29.81 ENST00000311604.8
lymphocyte specific protein 1
chr5_+_96876480 29.75 ENST00000437043.8
ENST00000379904.8
endoplasmic reticulum aminopeptidase 2
chr7_-_77416300 29.44 ENST00000257626.12
gamma-secretase activating protein
chr20_+_408278 29.17 ENST00000356286.10
ENST00000382181.2
ENST00000400247.3
RANBP2-type and C3HC4-type zinc finger containing 1
chr3_-_121660892 29.17 ENST00000428394.6
ENST00000314583.8
hematopoietic cell-specific Lyn substrate 1
chr17_+_6755834 28.80 ENST00000346752.8
XIAP associated factor 1
chr2_-_191014137 28.36 ENST00000673777.1
ENST00000673942.1
ENST00000424722.6
ENST00000392322.7
ENST00000361099.8
ENST00000392323.6
ENST00000673816.1
ENST00000673847.1
ENST00000673952.1
ENST00000540176.6
ENST00000673841.1
signal transducer and activator of transcription 1
chr12_+_25052634 28.33 ENST00000548766.5
inositol 1,4,5-triphosphate receptor associated 2
chr1_+_2556361 27.91 ENST00000355716.5
TNF receptor superfamily member 14
chr19_+_49335396 27.78 ENST00000598095.5
ENST00000426897.6
ENST00000323906.9
ENST00000535669.6
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr1_-_150765785 26.66 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr6_+_37433197 26.66 ENST00000455891.5
ENST00000373451.9
cap methyltransferase 1
chr6_-_32953017 26.60 ENST00000395305.7
ENST00000374843.9
ENST00000395303.7
ENST00000429234.1
major histocompatibility complex, class II, DM alpha
novel protein
chr12_+_53461015 26.55 ENST00000553064.6
ENST00000547859.2
poly(rC) binding protein 2
chr14_+_24161257 26.49 ENST00000396864.8
ENST00000557894.5
ENST00000559284.5
ENST00000560275.5
interferon regulatory factor 9
chr12_+_6452024 26.33 ENST00000266556.8
ENST00000544021.5
TAP binding protein like
chr10_+_89332484 26.14 ENST00000371811.4
ENST00000680037.1
ENST00000679583.1
ENST00000679897.1
interferon induced protein with tetratricopeptide repeats 3
chr6_-_24719146 25.82 ENST00000378119.9
chromosome 6 open reading frame 62
chr1_-_27672178 25.47 ENST00000339145.8
ENST00000361157.11
ENST00000362020.4
ENST00000679644.1
interferon alpha inducible protein 6
chr6_+_25962792 25.44 ENST00000357085.5
tripartite motif containing 38
chr12_-_53200443 25.01 ENST00000550743.6
integrin subunit beta 7
chr5_-_150412743 24.72 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74 molecule
chr16_+_11965234 24.64 ENST00000562385.1
TNF receptor superfamily member 17
chr10_+_89392546 24.55 ENST00000546318.2
ENST00000371804.4
interferon induced protein with tetratricopeptide repeats 1
chr6_-_158818225 24.54 ENST00000337147.11
ezrin
chr7_-_139109337 24.34 ENST00000464606.5
zinc finger CCCH-type containing, antiviral 1
chr2_+_230327218 24.31 ENST00000243810.10
ENST00000396563.8
SP140 nuclear body protein like
chr2_+_230327160 24.26 ENST00000444636.5
ENST00000415673.7
SP140 nuclear body protein like
chr11_-_4393650 24.25 ENST00000254436.8
tripartite motif containing 21
chr9_+_2159672 24.10 ENST00000634343.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_95822711 23.97 ENST00000512469.2
ENST00000379979.8
ENST00000505427.1
ENST00000508780.5
ENST00000237858.11
glutaredoxin
chr11_+_5624987 23.78 ENST00000429814.3
tripartite motif containing 34
chr2_+_85584402 23.77 ENST00000306384.5
vesicle associated membrane protein 5
chr7_-_106284524 23.76 ENST00000681936.1
ENST00000680786.1
ENST00000681550.1
nicotinamide phosphoribosyltransferase
chr3_-_146544538 23.71 ENST00000462666.5
phospholipid scramblase 1
chr5_+_50666660 23.44 ENST00000515175.6
poly(ADP-ribose) polymerase family member 8
chr2_+_86441341 23.44 ENST00000312912.10
ENST00000409064.5
lysine demethylase 3A
chr3_-_30894661 23.38 ENST00000282538.10
ENST00000454381.3
glutamate decarboxylase like 1
chr3_-_146544850 23.24 ENST00000472349.1
phospholipid scramblase 1
chr2_+_201129826 23.10 ENST00000457277.5
CASP8 and FADD like apoptosis regulator
chr17_+_6756035 23.00 ENST00000361842.8
ENST00000574907.5
XIAP associated factor 1
chr15_+_78540405 22.93 ENST00000560217.5
ENST00000559082.5
ENST00000559948.5
ENST00000413382.6
ENST00000559146.5
ENST00000044462.12
ENST00000558281.5
proteasome 20S subunit alpha 4
chr2_+_201116143 22.88 ENST00000443227.5
ENST00000309955.8
ENST00000341222.10
ENST00000341582.10
CASP8 and FADD like apoptosis regulator
chr6_-_109381739 22.57 ENST00000504373.2
CD164 molecule
chr3_-_146544578 22.53 ENST00000342435.9
ENST00000448787.6
phospholipid scramblase 1
chr5_-_143404129 22.50 ENST00000394466.6
nuclear receptor subfamily 3 group C member 1
chr6_-_31357171 22.37 ENST00000412585.7
ENST00000434333.1
major histocompatibility complex, class I, B
chr14_-_24146596 22.18 ENST00000560410.5
ENST00000216802.10
ENST00000615264.4
ENST00000630027.1
proteasome activator subunit 2
chr14_+_34982674 21.88 ENST00000554803.5
ENST00000546080.6
ENST00000555746.6
ENST00000678963.1
signal recognition particle 54
chr9_-_32526185 21.79 ENST00000379883.3
ENST00000379868.6
ENST00000679859.1
DExD/H-box helicase 58
chr16_+_29820394 21.53 ENST00000563915.5
ENST00000395353.5
major vault protein
chr18_+_3262956 21.50 ENST00000584539.1
myosin light chain 12B
chr12_+_112906949 21.27 ENST00000679971.1
ENST00000675868.2
ENST00000550883.2
ENST00000553152.2
ENST00000202917.10
ENST00000679467.1
ENST00000680659.1
ENST00000540589.3
ENST00000552526.2
ENST00000681228.1
ENST00000680934.1
ENST00000681700.1
ENST00000679987.1
2'-5'-oligoadenylate synthetase 1
chr2_+_201257980 21.13 ENST00000447616.5
ENST00000358485.8
ENST00000392266.7
caspase 8
chr1_-_24964984 21.10 ENST00000338888.3
ENST00000399916.5
RUNX family transcription factor 3
chr9_-_98119184 21.05 ENST00000342043.3
ENST00000375098.7
ENST00000341469.7
tripartite motif containing 14
chr4_-_82844418 20.96 ENST00000503937.5
SEC31 homolog A, COPII coat complex component
chr15_-_79971164 20.77 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2 related protein A1
chr12_+_112907006 20.50 ENST00000680455.1
ENST00000551241.6
ENST00000550689.2
ENST00000679841.1
ENST00000679494.1
ENST00000553185.2
2'-5'-oligoadenylate synthetase 1
chr5_+_119354771 20.45 ENST00000503646.1
TNF alpha induced protein 8
chr16_-_75647655 20.38 ENST00000570215.1
ENST00000319410.9
ENST00000302445.8
lysyl-tRNA synthetase 1
chr16_+_29820436 20.32 ENST00000357402.10
ENST00000566066.5
ENST00000563558.5
major vault protein
chr4_+_37891060 20.03 ENST00000261439.9
ENST00000508802.5
ENST00000402522.1
TBC1 domain family member 1
chr5_-_96807899 20.00 ENST00000503921.5
ENST00000508227.5
ENST00000507154.1
ENST00000443439.7
endoplasmic reticulum aminopeptidase 1
chr17_+_18476737 19.95 ENST00000581545.5
ENST00000582333.5
ENST00000328114.11
ENST00000583322.5
ENST00000584941.5
galectin 9C
chr12_+_112906777 19.88 ENST00000452357.7
ENST00000445409.7
2'-5'-oligoadenylate synthetase 1
chr11_-_67401782 19.87 ENST00000527663.6
ENST00000312989.11
ENST00000376745.9
ENST00000358239.8
protein phosphatase 1 catalytic subunit alpha
chr2_-_191013955 19.80 ENST00000409465.5
signal transducer and activator of transcription 1
chr14_+_91114431 19.63 ENST00000428926.6
ENST00000517362.5
D-glutamate cyclase
chr4_-_102827114 19.53 ENST00000343106.9
ubiquitin conjugating enzyme E2 D3
chr14_+_91114667 19.21 ENST00000523894.5
ENST00000522322.5
ENST00000523771.5
D-glutamate cyclase
chr12_-_31326111 19.15 ENST00000539409.5
SIN3-HDAC complex associated factor
chr2_+_201129318 19.12 ENST00000417748.1
CASP8 and FADD like apoptosis regulator
chr2_+_201129483 18.87 ENST00000440180.5
CASP8 and FADD like apoptosis regulator
chr1_-_153946652 18.82 ENST00000361217.9
DENN domain containing 4B
chr3_+_107522936 18.80 ENST00000415149.6
ENST00000402543.5
ENST00000325805.13
ENST00000427402.5
BBX high mobility group box domain containing
chr12_-_31326142 18.74 ENST00000337682.9
SIN3-HDAC complex associated factor
chr14_+_34982963 18.72 ENST00000678627.1
ENST00000216774.11
ENST00000555557.5
signal recognition particle 54
chr16_-_75647624 18.71 ENST00000568378.5
ENST00000568682.5
lysyl-tRNA synthetase 1
chr11_+_60455839 18.70 ENST00000532491.5
ENST00000532073.5
ENST00000345732.9
ENST00000534668.6
ENST00000528313.1
ENST00000533306.6
ENST00000674194.1
membrane spanning 4-domains A1
chr3_+_42149222 18.49 ENST00000449246.5
ENST00000613405.4
trafficking kinesin protein 1
chr17_-_42112674 18.44 ENST00000251642.8
ENST00000591220.5
DExH-box helicase 58
chr1_+_211326615 18.31 ENST00000336184.6
TNF receptor associated factor 5
chr21_+_41426232 17.96 ENST00000398598.8
ENST00000681896.1
ENST00000680629.1
ENST00000680760.1
ENST00000680176.1
ENST00000680776.1
ENST00000681607.1
ENST00000680536.1
MX dynamin like GTPase 1
chr12_+_103930600 17.89 ENST00000680316.1
ENST00000679861.1
heat shock protein 90 beta family member 1
chr1_+_211326787 17.75 ENST00000261464.10
TNF receptor associated factor 5
chr14_+_73097027 17.66 ENST00000532192.1
RNA binding motif protein 25
chr3_+_152299392 17.54 ENST00000498502.5
ENST00000545754.5
ENST00000357472.7
ENST00000324196.9
muscleblind like splicing regulator 1
chr22_-_36160773 17.36 ENST00000531095.1
ENST00000349314.6
ENST00000397293.6
apolipoprotein L3
chr10_-_121975168 17.27 ENST00000369017.5
ENST00000369023.8
NSE4 homolog A, SMC5-SMC6 complex component
chr11_-_73976952 17.00 ENST00000545212.1
uncoupling protein 2
chr11_+_313391 16.97 ENST00000680802.1
ENST00000528780.5
ENST00000681761.1
ENST00000681821.1
ENST00000328221.5
interferon induced transmembrane protein 1
chr6_-_26056460 16.76 ENST00000343677.4
H1.2 linker histone, cluster member
chr18_+_50879056 16.74 ENST00000321341.11
ENST00000638937.1
ENST00000382927.3
ENST00000639850.1
ENST00000638410.1
ENST00000639255.1
ENST00000640965.1
malic enzyme 2
chr11_-_104968533 16.31 ENST00000444739.7
caspase 4
chr6_+_26402237 16.28 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
butyrophilin subfamily 3 member A1
chr11_-_65614195 16.03 ENST00000309100.8
ENST00000529839.1
ENST00000526293.1
mitogen-activated protein kinase kinase kinase 11
chr4_-_25863537 15.65 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L family member 3
chr11_+_308408 15.65 ENST00000399815.2
novel protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
52.4 157.1 GO:0046967 cytosol to ER transport(GO:0046967)
51.5 154.4 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
45.1 225.5 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
37.7 113.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
33.4 267.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
31.4 94.2 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
29.5 59.0 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
23.2 116.1 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
21.8 436.4 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
19.4 154.8 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
19.2 96.1 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
18.1 180.5 GO:0018377 protein myristoylation(GO:0018377)
17.3 51.9 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
16.4 180.1 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
16.1 48.2 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
15.7 62.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
15.2 91.1 GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane(GO:1990668)
13.8 41.5 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
12.9 77.3 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
12.0 36.1 GO:0034769 basement membrane disassembly(GO:0034769)
11.0 66.2 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
10.7 32.2 GO:0035915 pore formation in membrane of other organism(GO:0035915)
10.1 40.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
9.0 27.1 GO:1990108 protein linear deubiquitination(GO:1990108)
8.9 26.6 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
8.7 886.1 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
8.6 102.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
8.5 51.2 GO:0070383 DNA cytosine deamination(GO:0070383)
8.3 74.4 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
8.2 24.5 GO:0051097 negative regulation of helicase activity(GO:0051097)
8.2 228.3 GO:0072643 interferon-gamma secretion(GO:0072643)
7.8 23.4 GO:0046292 formaldehyde metabolic process(GO:0046292)
7.8 163.9 GO:0035455 response to interferon-alpha(GO:0035455)
7.5 67.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
7.3 29.2 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
7.0 63.3 GO:0089700 protein kinase D signaling(GO:0089700)
7.0 27.9 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
6.7 26.9 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
6.6 33.0 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
6.6 26.4 GO:0039516 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
6.5 45.5 GO:0000255 allantoin metabolic process(GO:0000255)
6.3 56.8 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
6.3 25.0 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
5.6 39.5 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
5.0 15.0 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
4.7 28.1 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
4.6 18.5 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
4.6 64.1 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
4.5 22.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
4.3 12.8 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
4.2 16.7 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
4.2 199.2 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
4.1 33.2 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
4.1 20.4 GO:1902044 Fas signaling pathway(GO:0036337) regulation of Fas signaling pathway(GO:1902044)
4.0 11.9 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
3.8 26.7 GO:0080009 mRNA methylation(GO:0080009)
3.8 34.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
3.8 15.2 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
3.7 14.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
3.6 14.5 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
3.6 10.7 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
3.4 13.6 GO:0006272 leading strand elongation(GO:0006272)
3.2 9.6 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
3.1 12.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
3.1 18.8 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
3.1 55.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
3.1 36.7 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
3.0 21.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
3.0 14.9 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
2.8 11.3 GO:0033625 positive regulation of integrin activation(GO:0033625)
2.8 11.3 GO:0005986 sucrose biosynthetic process(GO:0005986)
2.8 8.3 GO:0045062 extrathymic T cell selection(GO:0045062)
2.8 13.8 GO:0006741 NADP biosynthetic process(GO:0006741)
2.7 16.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
2.7 16.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.5 32.5 GO:0010623 programmed cell death involved in cell development(GO:0010623)
2.5 41.8 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
2.4 17.0 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
2.4 31.5 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
2.4 16.7 GO:1902031 regulation of NADP metabolic process(GO:1902031)
2.3 7.0 GO:2000753 regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755)
2.3 9.3 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
2.3 9.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
2.3 9.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
2.2 13.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
2.2 99.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
2.1 12.9 GO:0042256 mature ribosome assembly(GO:0042256)
2.1 19.2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
2.1 55.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
2.0 12.2 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
2.0 16.0 GO:0007256 activation of JNKK activity(GO:0007256)
2.0 2.0 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
2.0 29.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
2.0 25.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.9 11.6 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
1.9 7.7 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.9 7.7 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
1.9 105.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
1.9 7.6 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
1.9 7.4 GO:0002384 hepatic immune response(GO:0002384)
1.8 7.2 GO:0016554 cytidine to uridine editing(GO:0016554)
1.8 1.8 GO:2000152 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) regulation of ubiquitin-specific protease activity(GO:2000152) negative regulation of ubiquitin-specific protease activity(GO:2000157)
1.7 13.8 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
1.7 3.4 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
1.7 10.1 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
1.7 5.1 GO:1903028 positive regulation of opsonization(GO:1903028)
1.6 4.8 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
1.6 38.3 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
1.5 6.2 GO:2000653 regulation of genetic imprinting(GO:2000653)
1.5 9.0 GO:0031437 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.5 26.5 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.4 10.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.4 170.7 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
1.4 5.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.3 65.3 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
1.3 23.8 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
1.3 19.7 GO:0035456 response to interferon-beta(GO:0035456)
1.3 16.9 GO:0043983 histone H4-K12 acetylation(GO:0043983)
1.3 9.1 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
1.3 9.0 GO:0016584 nucleosome positioning(GO:0016584)
1.3 24.0 GO:0045838 positive regulation of membrane potential(GO:0045838)
1.2 6.0 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
1.2 21.0 GO:0032897 negative regulation of viral transcription(GO:0032897)
1.2 106.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
1.2 8.1 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
1.1 8.9 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
1.1 5.5 GO:1904764 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
1.1 2.2 GO:0034756 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
1.1 16.6 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
1.1 8.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
1.1 3.3 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) negative regulation of mitotic cell cycle DNA replication(GO:1903464) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.1 4.4 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
1.1 3.3 GO:0061386 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.1 43.9 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
1.1 2.1 GO:0071283 cellular response to iron(III) ion(GO:0071283)
1.1 53.8 GO:0002260 lymphocyte homeostasis(GO:0002260)
1.1 4.2 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
1.0 5.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
1.0 38.7 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
1.0 7.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.0 2.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
1.0 4.1 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.0 3.0 GO:0006059 hexitol metabolic process(GO:0006059)
1.0 4.0 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
1.0 6.0 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
1.0 144.3 GO:0015992 proton transport(GO:0015992)
1.0 11.7 GO:0001675 acrosome assembly(GO:0001675)
1.0 4.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
1.0 4.8 GO:0035566 regulation of metanephros size(GO:0035566)
0.9 4.7 GO:0070842 aggresome assembly(GO:0070842)
0.9 15.0 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.9 12.1 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.9 6.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.9 2.7 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.9 4.4 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.9 2.7 GO:0009720 detection of hormone stimulus(GO:0009720)
0.9 24.6 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.9 6.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.9 5.2 GO:0070836 caveola assembly(GO:0070836)
0.9 18.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.9 11.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.9 12.8 GO:0016180 snRNA processing(GO:0016180)
0.8 11.7 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.8 13.3 GO:0016578 histone deubiquitination(GO:0016578)
0.8 35.8 GO:0002456 T cell mediated immunity(GO:0002456)
0.8 6.6 GO:0015886 heme transport(GO:0015886)
0.8 9.7 GO:0034138 toll-like receptor 3 signaling pathway(GO:0034138)
0.8 6.3 GO:0002353 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.8 19.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.8 7.0 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.8 7.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.8 4.5 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.7 10.9 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.7 2.1 GO:0090309 regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.7 0.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.7 2.1 GO:0007518 myoblast fate determination(GO:0007518)
0.7 20.4 GO:0042100 B cell proliferation(GO:0042100)
0.7 4.8 GO:0046449 creatinine metabolic process(GO:0046449)
0.7 2.7 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.7 2.0 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.7 19.0 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.7 16.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.6 2.6 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.6 7.6 GO:0015939 pantothenate metabolic process(GO:0015939)
0.6 2.4 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.6 1.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.6 1.8 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.6 1.8 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.6 31.8 GO:0006298 mismatch repair(GO:0006298)
0.6 1.1 GO:2000525 negative regulation of regulatory T cell differentiation(GO:0045590) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.6 3.4 GO:0097338 response to clozapine(GO:0097338)
0.6 3.9 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.5 5.5 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.5 12.0 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.5 11.4 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.5 1.6 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.5 4.7 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.5 6.2 GO:0010225 response to UV-C(GO:0010225)
0.5 6.0 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.5 1.0 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.5 10.3 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.5 1.0 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252) regulation of forebrain neuron differentiation(GO:2000977)
0.5 0.5 GO:1990791 dorsal root ganglion development(GO:1990791)
0.5 1.9 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.5 9.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.5 4.5 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.4 3.1 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.4 3.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.4 5.6 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.4 2.1 GO:0090385 phagosome acidification(GO:0090383) phagosome-lysosome fusion(GO:0090385)
0.4 0.8 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.4 26.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.4 2.4 GO:0043248 proteasome assembly(GO:0043248)
0.4 2.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.4 5.9 GO:0097320 membrane tubulation(GO:0097320)
0.4 5.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.4 3.8 GO:0033227 dsRNA transport(GO:0033227)
0.4 14.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.4 2.6 GO:0032480 negative regulation of type I interferon production(GO:0032480)
0.4 0.7 GO:0021553 olfactory nerve development(GO:0021553)
0.4 2.9 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.4 1.4 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916) chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.4 3.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.3 2.1 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.3 2.4 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.3 0.7 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693)
0.3 4.4 GO:0006828 manganese ion transport(GO:0006828)
0.3 14.9 GO:0019731 antibacterial humoral response(GO:0019731)
0.3 1.6 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.3 3.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 2.1 GO:0015866 ADP transport(GO:0015866)
0.3 10.0 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3 12.5 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.3 13.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 20.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 4.6 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.3 0.9 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.3 5.3 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.3 4.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.3 1.6 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.3 2.1 GO:0045901 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.3 38.0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 9.9 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.3 5.7 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.3 1.3 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.2 2.2 GO:0009249 protein lipoylation(GO:0009249)
0.2 6.4 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.2 12.4 GO:0051972 regulation of telomerase activity(GO:0051972)
0.2 40.6 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.2 1.4 GO:0015755 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.2 2.9 GO:0070914 UV-damage excision repair(GO:0070914)
0.2 9.8 GO:0051205 protein insertion into membrane(GO:0051205)
0.2 2.6 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.2 7.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 3.7 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.2 1.8 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.2 0.9 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.2 0.9 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 2.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.2 3.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 3.9 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.2 3.0 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.2 0.4 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.2 11.1 GO:0045576 mast cell activation(GO:0045576)
0.2 1.0 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.2 10.7 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.2 18.7 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.2 2.0 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.2 2.4 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.2 14.0 GO:0006334 nucleosome assembly(GO:0006334)
0.2 4.8 GO:0006491 N-glycan processing(GO:0006491)
0.2 28.8 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.2 11.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 5.0 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.2 3.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 94.4 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.2 14.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.2 4.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 2.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 7.2 GO:0048477 oogenesis(GO:0048477)
0.2 1.3 GO:0035989 tendon development(GO:0035989)
0.2 2.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 0.8 GO:0021764 amygdala development(GO:0021764)
0.2 0.5 GO:1903412 response to bile acid(GO:1903412) cellular response to bile acid(GO:1903413)
0.1 2.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 9.3 GO:0002200 somatic diversification of immune receptors(GO:0002200)
0.1 2.8 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.1 9.2 GO:0006968 cellular defense response(GO:0006968)
0.1 30.2 GO:0009615 response to virus(GO:0009615)
0.1 19.7 GO:0006310 DNA recombination(GO:0006310)
0.1 0.8 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.1 0.4 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.1 6.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 4.1 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 2.1 GO:0032418 lysosome localization(GO:0032418)
0.1 0.6 GO:0090168 Golgi reassembly(GO:0090168)
0.1 4.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 1.7 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 4.3 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 0.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.7 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) histone H2A K63-linked ubiquitination(GO:0070535) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.3 GO:0097272 ammonia homeostasis(GO:0097272)
0.1 4.7 GO:0030641 regulation of cellular pH(GO:0030641)
0.1 4.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 2.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 3.8 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 1.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 2.9 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 0.8 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 5.3 GO:0007498 mesoderm development(GO:0007498)
0.1 0.3 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 0.7 GO:0006105 succinate metabolic process(GO:0006105)
0.0 1.1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.0 0.2 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 1.6 GO:0030317 sperm motility(GO:0030317)
0.0 2.6 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 3.6 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 1.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.3 GO:0030183 B cell differentiation(GO:0030183)
0.0 2.0 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.3 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.6 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 1.7 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.2 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 1.2 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.1 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.8 GO:0007286 spermatid development(GO:0007286)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
75.9 531.3 GO:1990111 spermatoproteasome complex(GO:1990111)
49.6 248.2 GO:0042825 TAP complex(GO:0042825)
23.5 117.6 GO:0097169 AIM2 inflammasome complex(GO:0097169)
20.7 82.9 GO:0008537 proteasome activator complex(GO:0008537)
12.8 51.4 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
11.8 59.0 GO:0031905 early endosome lumen(GO:0031905)
11.2 67.2 GO:0071797 LUBAC complex(GO:0071797)
10.2 30.5 GO:0044393 microspike(GO:0044393)
9.4 47.0 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
9.2 202.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
8.9 80.4 GO:0032010 phagolysosome(GO:0032010)
6.9 82.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
6.8 47.6 GO:0043196 varicosity(GO:0043196)
6.3 25.0 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
5.8 23.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
5.6 39.1 GO:0030905 retromer, tubulation complex(GO:0030905)
5.4 37.7 GO:0044530 supraspliceosomal complex(GO:0044530)
5.0 14.9 GO:0071756 IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
4.5 40.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
4.5 40.2 GO:0043020 NADPH oxidase complex(GO:0043020)
4.5 13.4 GO:0036398 TCR signalosome(GO:0036398)
4.4 57.0 GO:0005688 U6 snRNP(GO:0005688)
4.0 24.0 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
3.9 27.4 GO:0036021 endolysosome lumen(GO:0036021)
3.6 10.7 GO:1990622 CHOP-ATF3 complex(GO:1990622)
3.4 50.3 GO:0035631 CD40 receptor complex(GO:0035631)
3.2 9.6 GO:1902737 dendritic filopodium(GO:1902737)
3.0 23.6 GO:0072487 MSL complex(GO:0072487)
2.9 202.5 GO:0015030 Cajal body(GO:0015030)
2.9 11.7 GO:0020003 symbiont-containing vacuole(GO:0020003)
2.7 13.6 GO:0070557 PCNA-p21 complex(GO:0070557)
2.7 51.3 GO:0042613 MHC class II protein complex(GO:0042613)
2.7 29.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
2.6 23.6 GO:0097452 GAIT complex(GO:0097452)
2.2 6.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
2.0 264.5 GO:0035578 azurophil granule lumen(GO:0035578)
1.9 19.0 GO:0070552 BRISC complex(GO:0070552)
1.8 32.0 GO:0005840 ribosome(GO:0005840)
1.8 7.0 GO:0044307 dendritic branch(GO:0044307)
1.6 12.5 GO:0044754 autolysosome(GO:0044754)
1.5 13.7 GO:0042382 paraspeckles(GO:0042382)
1.5 11.9 GO:0005827 polar microtubule(GO:0005827)
1.5 7.4 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.5 180.3 GO:0005643 nuclear pore(GO:0005643)
1.3 5.3 GO:0033391 chromatoid body(GO:0033391)
1.3 7.7 GO:0070765 gamma-secretase complex(GO:0070765)
1.3 9.0 GO:0016589 NURF complex(GO:0016589)
1.3 80.4 GO:0035577 azurophil granule membrane(GO:0035577)
1.3 10.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
1.2 6.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
1.2 3.7 GO:0005674 transcription factor TFIIF complex(GO:0005674)
1.2 20.5 GO:0030127 COPII vesicle coat(GO:0030127)
1.2 17.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
1.2 22.4 GO:0098553 integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
1.2 12.8 GO:0032039 integrator complex(GO:0032039)
1.2 12.7 GO:0030870 Mre11 complex(GO:0030870)
1.2 38.0 GO:0000421 autophagosome membrane(GO:0000421)
1.2 458.9 GO:0031965 nuclear membrane(GO:0031965)
1.1 53.8 GO:0031258 lamellipodium membrane(GO:0031258)
1.1 5.5 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.1 4.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
1.0 5.2 GO:0097165 nuclear stress granule(GO:0097165)
1.0 3.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.8 7.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.8 6.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.8 10.0 GO:0005577 fibrinogen complex(GO:0005577)
0.8 7.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.8 4.0 GO:0031519 PcG protein complex(GO:0031519)
0.8 3.1 GO:0000243 commitment complex(GO:0000243)
0.7 25.1 GO:0016514 SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564)
0.7 9.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.7 23.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.7 19.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.7 4.1 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.7 3.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 10.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.6 17.4 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.6 1.8 GO:0034455 t-UTP complex(GO:0034455)
0.6 6.4 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.6 16.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.6 5.6 GO:0005677 chromatin silencing complex(GO:0005677)
0.5 6.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 6.0 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.5 24.5 GO:0097542 ciliary tip(GO:0097542)
0.5 229.8 GO:0016607 nuclear speck(GO:0016607)
0.5 10.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.5 6.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.5 13.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 5.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.4 28.3 GO:0001772 immunological synapse(GO:0001772)
0.4 6.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.4 13.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.4 20.9 GO:0099738 cell cortex region(GO:0099738)
0.4 2.7 GO:0035861 site of double-strand break(GO:0035861)
0.4 2.2 GO:0033269 internode region of axon(GO:0033269)
0.4 14.0 GO:0016235 aggresome(GO:0016235)
0.4 7.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 10.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 7.8 GO:0000502 proteasome complex(GO:0000502)
0.4 16.3 GO:0032838 cell projection cytoplasm(GO:0032838) axon cytoplasm(GO:1904115)
0.3 17.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 15.9 GO:0005876 spindle microtubule(GO:0005876)
0.3 4.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 4.9 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 20.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 33.2 GO:0031985 Golgi cisterna(GO:0031985)
0.3 2.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 12.6 GO:0005776 autophagosome(GO:0005776)
0.3 44.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.3 1.4 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.3 4.2 GO:0043083 synaptic cleft(GO:0043083)
0.3 0.8 GO:0005592 collagen type XI trimer(GO:0005592)
0.3 16.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 4.4 GO:0045171 intercellular bridge(GO:0045171)
0.3 47.5 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 9.2 GO:0031201 SNARE complex(GO:0031201)
0.2 20.0 GO:0005814 centriole(GO:0005814)
0.2 121.8 GO:0005730 nucleolus(GO:0005730)
0.2 5.9 GO:0005681 spliceosomal complex(GO:0005681)
0.2 58.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 34.5 GO:0005802 trans-Golgi network(GO:0005802)
0.2 75.6 GO:0000790 nuclear chromatin(GO:0000790)
0.2 22.0 GO:0005635 nuclear envelope(GO:0005635)
0.2 33.3 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.1 GO:0032009 early phagosome(GO:0032009)
0.2 669.5 GO:0005654 nucleoplasm(GO:0005654)
0.2 7.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 12.6 GO:0005667 transcription factor complex(GO:0005667)
0.2 12.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 1.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 7.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 1.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 180.6 GO:0005739 mitochondrion(GO:0005739)
0.1 10.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 6.7 GO:0035580 specific granule lumen(GO:0035580)
0.1 5.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.0 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.7 GO:0000815 ESCRT III complex(GO:0000815)
0.1 23.1 GO:0005769 early endosome(GO:0005769)
0.1 0.6 GO:0032059 bleb(GO:0032059)
0.1 3.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 30.5 GO:0000139 Golgi membrane(GO:0000139)
0.1 7.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 4.9 GO:0005604 basement membrane(GO:0005604)
0.1 4.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.1 GO:0043195 terminal bouton(GO:0043195)
0.0 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
42.1 252.5 GO:0046979 TAP2 binding(GO:0046979)
37.7 113.2 GO:0008859 exoribonuclease II activity(GO:0008859)
25.5 152.8 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
22.3 623.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
16.4 213.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
16.2 48.6 GO:0048030 disaccharide binding(GO:0048030)
15.8 47.5 GO:0032090 Pyrin domain binding(GO:0032090)
13.7 68.4 GO:0004771 sterol esterase activity(GO:0004771)
11.8 82.9 GO:0061133 endopeptidase activator activity(GO:0061133)
11.4 102.7 GO:0031685 adenosine receptor binding(GO:0031685)
11.0 55.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
10.9 151.9 GO:0031386 protein tag(GO:0031386)
10.9 54.3 GO:0042296 ISG15 transferase activity(GO:0042296)
10.3 61.9 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
10.1 80.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
9.2 275.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
9.1 145.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
8.1 48.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
7.8 23.4 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
6.8 34.2 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
6.8 40.6 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
5.8 17.5 GO:0001069 regulatory region RNA binding(GO:0001069)
5.3 26.7 GO:0008174 mRNA methyltransferase activity(GO:0008174)
5.2 36.1 GO:0031996 thioesterase binding(GO:0031996)
5.0 15.1 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
4.8 24.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
4.8 23.8 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
4.5 13.6 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
4.5 99.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
4.3 17.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
4.1 16.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
4.0 24.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
4.0 16.0 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
4.0 11.9 GO:0031208 POZ domain binding(GO:0031208)
4.0 19.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
3.8 103.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
3.8 15.1 GO:0098770 FBXO family protein binding(GO:0098770)
3.7 14.9 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
3.3 16.7 GO:0008948 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
3.3 13.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
3.2 12.9 GO:0043273 CTPase activity(GO:0043273)
3.1 24.9 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
3.1 9.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
3.0 9.1 GO:0042008 interleukin-18 receptor activity(GO:0042008)
3.0 36.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
2.9 108.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
2.8 11.3 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
2.8 19.3 GO:0042289 MHC class II protein binding(GO:0042289)
2.7 70.8 GO:0004697 protein kinase C activity(GO:0004697)
2.7 24.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
2.6 7.9 GO:0031849 olfactory receptor binding(GO:0031849)
2.6 117.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
2.6 79.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
2.5 7.4 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
2.5 41.9 GO:0019864 IgG binding(GO:0019864)
2.3 27.5 GO:0004000 adenosine deaminase activity(GO:0004000)
2.2 11.1 GO:1990460 leptin receptor binding(GO:1990460)
2.2 15.2 GO:0004849 uridine kinase activity(GO:0004849)
2.1 32.2 GO:1901612 cardiolipin binding(GO:1901612)
2.1 8.5 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
2.1 35.6 GO:0017154 semaphorin receptor activity(GO:0017154)
2.1 27.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
2.0 90.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
2.0 6.0 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
2.0 31.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.9 7.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
1.9 3.8 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
1.8 5.5 GO:0047756 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) chondroitin 4-sulfotransferase activity(GO:0047756)
1.8 50.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
1.7 12.2 GO:0019863 IgE binding(GO:0019863)
1.7 20.4 GO:0070087 chromo shadow domain binding(GO:0070087)
1.7 13.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.7 205.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
1.7 28.1 GO:0034452 dynactin binding(GO:0034452)
1.6 4.9 GO:0004556 alpha-amylase activity(GO:0004556)
1.6 14.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
1.6 6.4 GO:0032184 SUMO polymer binding(GO:0032184)
1.5 6.2 GO:0000405 bubble DNA binding(GO:0000405)
1.4 4.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.4 7.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
1.4 5.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.4 6.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
1.3 9.4 GO:0001849 complement component C1q binding(GO:0001849)
1.3 3.9 GO:0004531 deoxyribonuclease II activity(GO:0004531)
1.3 29.7 GO:0044548 S100 protein binding(GO:0044548)
1.3 232.8 GO:0001047 core promoter binding(GO:0001047)
1.3 9.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.3 24.0 GO:0051400 BH domain binding(GO:0051400)
1.2 438.0 GO:0003924 GTPase activity(GO:0003924)
1.2 36.1 GO:0001968 fibronectin binding(GO:0001968)
1.1 11.9 GO:0046790 virion binding(GO:0046790)
1.1 6.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.1 9.6 GO:0033592 RNA strand annealing activity(GO:0033592)
1.1 40.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.1 7.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
1.0 54.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.0 7.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
1.0 12.0 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
1.0 19.8 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
1.0 14.8 GO:0042834 peptidoglycan binding(GO:0042834)
1.0 20.6 GO:0001093 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) TFIIB-class transcription factor binding(GO:0001093)
1.0 22.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
1.0 19.5 GO:0032036 myosin heavy chain binding(GO:0032036)
1.0 9.7 GO:0035325 Toll-like receptor binding(GO:0035325)
1.0 27.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.9 7.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.9 15.0 GO:0042288 MHC class I protein binding(GO:0042288)
0.9 82.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.9 32.6 GO:0008143 poly(A) binding(GO:0008143)
0.9 6.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.9 14.5 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.9 2.7 GO:0034437 glycoprotein transporter activity(GO:0034437)
0.9 18.5 GO:0050811 GABA receptor binding(GO:0050811)
0.9 43.9 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.9 5.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.8 6.6 GO:0015232 heme transporter activity(GO:0015232)
0.8 31.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.8 13.6 GO:0005522 profilin binding(GO:0005522)
0.7 6.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.7 2.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.7 32.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.7 6.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.7 8.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.7 2.6 GO:0004074 biliverdin reductase activity(GO:0004074)
0.6 107.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.6 10.3 GO:0048156 tau protein binding(GO:0048156)
0.6 3.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.6 11.6 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.6 2.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.6 35.7 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.6 3.9 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.5 14.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 4.7 GO:0019211 phosphatase activator activity(GO:0019211)
0.5 9.2 GO:0004407 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.5 21.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.4 4.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 2.2 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.4 1.7 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.4 13.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.4 9.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 26.6 GO:0035064 methylated histone binding(GO:0035064)
0.4 17.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.4 1.6 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.4 5.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 6.2 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.4 5.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.4 3.4 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.4 28.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.4 5.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.4 2.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 2.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.3 197.6 GO:0003712 transcription cofactor activity(GO:0003712)
0.3 1.9 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 15.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.3 31.4 GO:0005525 GTP binding(GO:0005525)
0.3 8.4 GO:0048038 quinone binding(GO:0048038)
0.3 9.0 GO:0031491 nucleosome binding(GO:0031491)
0.3 5.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.3 0.9 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.3 2.1 GO:0005347 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.3 33.3 GO:0019903 protein phosphatase binding(GO:0019903)
0.3 4.7 GO:0070628 proteasome binding(GO:0070628)
0.3 3.6 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.3 1.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.3 1.6 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 4.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 56.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 4.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.3 3.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 5.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 1.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 3.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 21.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 4.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 1.4 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.2 4.7 GO:0008301 DNA binding, bending(GO:0008301)
0.2 9.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 4.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 1.8 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.2 2.5 GO:0016208 AMP binding(GO:0016208)
0.2 0.6 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.2 4.5 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.2 2.7 GO:0016805 dipeptidase activity(GO:0016805)
0.2 48.6 GO:0005096 GTPase activator activity(GO:0005096)
0.2 4.5 GO:0003951 NAD+ kinase activity(GO:0003951)
0.2 4.8 GO:0001848 complement binding(GO:0001848)
0.2 1.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.2 50.0 GO:0030246 carbohydrate binding(GO:0030246)
0.2 8.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 4.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 13.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 2.4 GO:0004985 opioid receptor activity(GO:0004985)
0.2 3.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 3.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.7 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 3.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 3.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 5.9 GO:0019894 kinesin binding(GO:0019894)
0.1 5.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 11.0 GO:0005254 chloride channel activity(GO:0005254)
0.1 2.6 GO:0043531 ADP binding(GO:0043531)
0.1 2.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 23.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 5.4 GO:0019902 phosphatase binding(GO:0019902)
0.1 36.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 4.4 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 2.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.8 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.9 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 8.6 GO:0005319 lipid transporter activity(GO:0005319)
0.1 0.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.1 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.3 GO:0042301 phosphate ion binding(GO:0042301)
0.1 2.5 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.0 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.2 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 1.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.7 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 1.0 GO:0032947 protein complex scaffold(GO:0032947)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 209.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
4.2 58.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
2.7 139.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
2.7 67.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
2.4 66.1 PID TRAIL PATHWAY TRAIL signaling pathway
2.4 213.9 PID RAC1 PATHWAY RAC1 signaling pathway
2.3 51.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
2.1 141.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
1.8 280.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
1.5 15.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
1.1 43.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
1.1 205.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
1.0 25.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
1.0 70.7 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.9 35.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.9 25.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.9 155.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.8 46.9 PID PLK1 PATHWAY PLK1 signaling events
0.8 37.7 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.7 15.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.7 13.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.7 26.0 PID ALK1 PATHWAY ALK1 signaling events
0.7 41.9 PID AURORA B PATHWAY Aurora B signaling
0.7 31.0 PID RHOA PATHWAY RhoA signaling pathway
0.6 2.9 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.6 21.6 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.5 19.2 PID BCR 5PATHWAY BCR signaling pathway
0.5 9.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.5 24.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.5 4.2 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.5 14.0 PID PI3KCI PATHWAY Class I PI3K signaling events
0.4 6.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.4 12.1 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.4 35.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 5.3 PID AURORA A PATHWAY Aurora A signaling
0.3 10.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 12.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.2 8.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 3.4 PID IL3 PATHWAY IL3-mediated signaling events
0.2 4.8 ST GA13 PATHWAY G alpha 13 Pathway
0.2 10.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.2 9.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 14.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 8.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 2.0 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.1 4.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 3.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 4.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 1.6 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 20.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 2.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 1.0 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.7 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.6 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
22.6 225.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
19.0 95.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
16.1 48.2 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
13.2 1422.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
10.2 757.0 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
8.3 266.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
6.8 67.9 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
5.6 101.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
5.4 260.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
2.8 50.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
2.6 57.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
2.3 43.9 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
2.1 35.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
2.0 62.7 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
1.6 129.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
1.5 38.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
1.5 17.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
1.3 9.3 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
1.1 16.9 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.0 15.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
1.0 23.3 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
1.0 4.8 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.9 41.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.9 42.0 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.9 11.1 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.8 4.2 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.8 7.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.8 6.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.7 24.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.7 36.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.7 29.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.7 3.3 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.6 45.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.6 14.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.6 13.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 48.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.6 34.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.6 50.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.5 3.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.5 5.7 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.5 5.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.5 10.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.4 12.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.4 55.1 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.4 10.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.4 10.7 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.4 25.8 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.4 4.5 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.4 5.7 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.3 8.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 10.6 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.3 21.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 8.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 13.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 11.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.3 27.6 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 8.4 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.3 46.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 3.0 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 11.4 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.2 13.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 6.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 2.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 4.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 3.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 20.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 7.8 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 1.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 3.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 20.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.2 6.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 8.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 6.4 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 1.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 1.3 REACTOME KERATAN SULFATE KERATIN METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.1 4.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 4.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 1.0 REACTOME DEFENSINS Genes involved in Defensins
0.1 2.1 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 5.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.1 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels