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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for IRF7
Z-value: 7.59
Motif logo
Transcription factors associated with IRF7
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
IRF7
|
ENSG00000185507.21 | IRF7 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF7 | hg38_v1_chr11_-_615570_615728 | -0.23 | 7.8e-04 | Click! |
Activity profile of IRF7 motif
Sorted Z-values of IRF7 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 25.6 | GO:1901254 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 5.9 | 5.9 | GO:1903895 | negative regulation of IRE1-mediated unfolded protein response(GO:1903895) |
| 5.8 | 58.2 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 4.4 | 17.8 | GO:0009956 | radial pattern formation(GO:0009956) |
| 4.2 | 12.7 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 3.9 | 15.5 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 3.8 | 11.3 | GO:0036292 | DNA rewinding(GO:0036292) |
| 3.7 | 41.1 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 3.6 | 10.9 | GO:0006059 | hexitol metabolic process(GO:0006059) |
| 3.6 | 21.5 | GO:0033490 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 2.9 | 8.7 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 2.9 | 8.7 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 2.8 | 11.2 | GO:0006238 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 2.7 | 11.0 | GO:0002188 | translation reinitiation(GO:0002188) |
| 2.6 | 7.7 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697) |
| 2.5 | 10.1 | GO:0090579 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 2.5 | 20.3 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 2.4 | 17.0 | GO:0052564 | response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572) |
| 2.4 | 16.9 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 2.4 | 11.8 | GO:0001971 | negative regulation of activation of membrane attack complex(GO:0001971) |
| 2.4 | 9.4 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 2.4 | 16.5 | GO:0030421 | defecation(GO:0030421) |
| 2.2 | 15.4 | GO:1905123 | regulation of glucosylceramidase activity(GO:1905123) |
| 2.2 | 15.3 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 2.2 | 4.3 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 2.1 | 30.1 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 2.1 | 8.3 | GO:1900186 | negative regulation of clathrin-mediated endocytosis(GO:1900186) |
| 2.0 | 10.1 | GO:0015866 | ADP transport(GO:0015866) |
| 1.9 | 5.8 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 1.9 | 11.5 | GO:0048669 | collateral sprouting in absence of injury(GO:0048669) |
| 1.8 | 14.0 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 1.7 | 12.2 | GO:0008215 | spermine metabolic process(GO:0008215) |
| 1.7 | 37.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 1.6 | 6.5 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 1.6 | 4.7 | GO:0072428 | signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926) |
| 1.6 | 12.4 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 1.5 | 4.6 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 1.5 | 23.8 | GO:1901673 | regulation of mitotic spindle assembly(GO:1901673) |
| 1.5 | 22.0 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 1.4 | 8.2 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
| 1.3 | 6.6 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 1.3 | 15.6 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 1.2 | 13.6 | GO:0007144 | female meiosis I(GO:0007144) |
| 1.2 | 29.5 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 1.2 | 12.8 | GO:2000795 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 1.1 | 16.9 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 1.1 | 11.1 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 1.1 | 6.6 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 1.1 | 15.3 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 1.1 | 9.8 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 1.1 | 14.2 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.1 | 5.3 | GO:0060353 | regulation of cell adhesion molecule production(GO:0060353) positive regulation of cell adhesion molecule production(GO:0060355) |
| 1.1 | 12.8 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 1.1 | 6.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.1 | 9.6 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 1.1 | 7.5 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 1.1 | 11.7 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 1.0 | 26.6 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 1.0 | 24.4 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 1.0 | 4.0 | GO:0036060 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
| 1.0 | 6.0 | GO:0043248 | proteasome assembly(GO:0043248) |
| 1.0 | 2.9 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of meiosis I(GO:0060903) |
| 1.0 | 4.8 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.0 | 3.8 | GO:0033313 | meiotic cell cycle checkpoint(GO:0033313) |
| 1.0 | 8.6 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.9 | 7.4 | GO:1901187 | regulation of ephrin receptor signaling pathway(GO:1901187) |
| 0.9 | 6.5 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.9 | 2.7 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) |
| 0.9 | 7.3 | GO:0072733 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.9 | 7.9 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.8 | 9.2 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.8 | 4.2 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.8 | 83.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.8 | 2.4 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.8 | 13.5 | GO:0060546 | negative regulation of necroptotic process(GO:0060546) |
| 0.8 | 4.8 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.8 | 11.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.8 | 3.2 | GO:1904753 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) negative regulation of vascular associated smooth muscle cell migration(GO:1904753) |
| 0.8 | 8.5 | GO:1903943 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.7 | 7.5 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 0.7 | 2.2 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.7 | 17.7 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.7 | 15.3 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.7 | 5.0 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.7 | 2.8 | GO:0018197 | peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.7 | 41.4 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.7 | 2.1 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 0.7 | 3.3 | GO:1903587 | regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.6 | 3.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.6 | 3.2 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.6 | 3.2 | GO:0070836 | plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836) |
| 0.6 | 11.2 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.6 | 1.8 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.6 | 4.7 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.6 | 4.7 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.6 | 2.9 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.6 | 6.3 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.6 | 1.1 | GO:1990169 | detoxification of copper ion(GO:0010273) elastin metabolic process(GO:0051541) stress response to copper ion(GO:1990169) |
| 0.6 | 6.8 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.6 | 6.8 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.6 | 11.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.6 | 1.7 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.6 | 3.3 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.6 | 3.3 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.5 | 3.8 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
| 0.5 | 1.6 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.5 | 2.1 | GO:0030821 | negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821) |
| 0.5 | 4.2 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.5 | 6.6 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.5 | 3.5 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.5 | 1.5 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 0.5 | 3.4 | GO:0010710 | regulation of collagen catabolic process(GO:0010710) |
| 0.5 | 2.9 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.5 | 3.3 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 0.5 | 25.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.5 | 7.6 | GO:0035898 | parathyroid hormone secretion(GO:0035898) post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828) |
| 0.5 | 4.3 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.5 | 4.7 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.5 | 2.3 | GO:1902474 | positive regulation of protein localization to synapse(GO:1902474) |
| 0.5 | 2.8 | GO:0006235 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
| 0.5 | 2.3 | GO:0045875 | negative regulation of sister chromatid cohesion(GO:0045875) |
| 0.5 | 4.6 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.5 | 3.7 | GO:0097324 | melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.5 | 6.8 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.4 | 3.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.4 | 7.1 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.4 | 4.4 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.4 | 1.3 | GO:1901252 | regulation of intracellular transport of viral material(GO:1901252) |
| 0.4 | 7.6 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.4 | 2.1 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.4 | 2.5 | GO:1903936 | response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936) |
| 0.4 | 10.4 | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770) |
| 0.4 | 22.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.4 | 10.0 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.4 | 2.7 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.4 | 3.0 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.4 | 5.9 | GO:0070444 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.4 | 13.5 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.4 | 6.7 | GO:0010944 | negative regulation of transcription by competitive promoter binding(GO:0010944) |
| 0.3 | 2.4 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.3 | 3.1 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.3 | 2.4 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.3 | 1.5 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.3 | 4.9 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.3 | 1.5 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.3 | 6.0 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.3 | 2.3 | GO:0030091 | protein repair(GO:0030091) |
| 0.3 | 0.9 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 0.3 | 4.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.3 | 8.0 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.3 | 1.4 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.3 | 1.1 | GO:0048880 | sensory system development(GO:0048880) |
| 0.3 | 2.1 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.3 | 1.3 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.3 | 9.7 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.3 | 16.0 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.3 | 1.5 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.3 | 1.3 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.3 | 6.1 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.3 | 2.6 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.3 | 8.4 | GO:0061641 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.3 | 9.9 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.3 | 6.8 | GO:0071498 | cellular response to fluid shear stress(GO:0071498) |
| 0.2 | 11.6 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.2 | 2.1 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.2 | 20.3 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.2 | 1.4 | GO:0051549 | regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549) |
| 0.2 | 0.9 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.2 | 0.9 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.2 | 0.6 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.2 | 4.8 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.2 | 0.6 | GO:0071314 | cellular response to cocaine(GO:0071314) |
| 0.2 | 14.2 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.2 | 4.3 | GO:0008228 | opsonization(GO:0008228) |
| 0.2 | 1.4 | GO:0010909 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.2 | 5.8 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.2 | 7.3 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.2 | 2.2 | GO:0006787 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.2 | 6.6 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.2 | 1.5 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.2 | 4.9 | GO:0033683 | nucleotide-excision repair, DNA incision(GO:0033683) |
| 0.2 | 3.6 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.2 | 6.6 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.2 | 9.0 | GO:0061718 | NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.2 | 1.6 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
| 0.2 | 1.4 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.2 | 12.8 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.2 | 2.1 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.1 | 0.7 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.1 | 0.6 | GO:0030070 | insulin processing(GO:0030070) |
| 0.1 | 8.3 | GO:0008542 | visual learning(GO:0008542) |
| 0.1 | 7.0 | GO:0061512 | protein localization to cilium(GO:0061512) |
| 0.1 | 1.4 | GO:0032096 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
| 0.1 | 0.3 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.1 | 0.4 | GO:0042231 | interleukin-13 biosynthetic process(GO:0042231) |
| 0.1 | 1.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.1 | 5.4 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.1 | 0.7 | GO:2000015 | regulation of determination of dorsal identity(GO:2000015) |
| 0.1 | 0.5 | GO:1902725 | negative regulation of satellite cell differentiation(GO:1902725) |
| 0.1 | 1.3 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.1 | 1.6 | GO:0075713 | establishment of integrated proviral latency(GO:0075713) |
| 0.1 | 0.2 | GO:0090158 | endoplasmic reticulum membrane organization(GO:0090158) |
| 0.1 | 1.1 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 7.0 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.1 | 3.6 | GO:0043276 | anoikis(GO:0043276) |
| 0.1 | 2.3 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 13.4 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.1 | 1.5 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 3.1 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.1 | 3.2 | GO:0006625 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 0.6 | GO:2000809 | positive regulation of presynaptic membrane organization(GO:1901631) positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.1 | 4.3 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 0.1 | 1.2 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.1 | 1.9 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.1 | 3.5 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.1 | 2.4 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.1 | 7.0 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.1 | 0.7 | GO:2000252 | negative regulation of feeding behavior(GO:2000252) |
| 0.1 | 3.2 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.1 | 11.2 | GO:0090002 | establishment of protein localization to plasma membrane(GO:0090002) |
| 0.1 | 4.7 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
| 0.1 | 0.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 1.1 | GO:0090656 | t-circle formation(GO:0090656) |
| 0.1 | 5.3 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.1 | 1.3 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.1 | 43.9 | GO:0030036 | actin cytoskeleton organization(GO:0030036) |
| 0.1 | 1.2 | GO:2000637 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 0.1 | 0.9 | GO:0055091 | regulation of lipoprotein metabolic process(GO:0050746) phospholipid homeostasis(GO:0055091) |
| 0.1 | 1.5 | GO:0002360 | T cell lineage commitment(GO:0002360) |
| 0.1 | 2.7 | GO:0045840 | positive regulation of mitotic nuclear division(GO:0045840) |
| 0.1 | 1.0 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.1 | 3.1 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 0.6 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.1 | 1.4 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.1 | 0.2 | GO:0090293 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) regulation of urea metabolic process(GO:0034255) bile acid signaling pathway(GO:0038183) intracellular bile acid receptor signaling pathway(GO:0038185) negative regulation of bile acid biosynthetic process(GO:0070858) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) negative regulation of bile acid metabolic process(GO:1904252) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
| 0.1 | 4.4 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.1 | 0.1 | GO:0098905 | regulation of bundle of His cell action potential(GO:0098905) regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825) |
| 0.1 | 1.2 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 1.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 1.3 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 1.6 | GO:2000816 | negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 0.0 | 0.7 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 0.8 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.0 | 0.1 | GO:0019075 | virus maturation(GO:0019075) |
| 0.0 | 0.5 | GO:1903203 | regulation of oxidative stress-induced neuron death(GO:1903203) negative regulation of oxidative stress-induced neuron death(GO:1903204) |
| 0.0 | 1.7 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 0.0 | 2.6 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 4.9 | GO:0032355 | response to estradiol(GO:0032355) |
| 0.0 | 1.5 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.1 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.0 | 0.3 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.0 | 1.9 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.0 | 1.0 | GO:0051205 | protein insertion into membrane(GO:0051205) |
| 0.0 | 3.3 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 3.5 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.0 | 0.1 | GO:0002857 | positive regulation of response to tumor cell(GO:0002836) positive regulation of immune response to tumor cell(GO:0002839) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 25.6 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 5.6 | 22.5 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 3.7 | 44.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 3.3 | 9.9 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 3.2 | 9.6 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 2.3 | 13.5 | GO:0071797 | LUBAC complex(GO:0071797) |
| 2.2 | 10.9 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 2.2 | 15.3 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 2.1 | 12.4 | GO:0097422 | tubular endosome(GO:0097422) |
| 1.9 | 49.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 1.9 | 11.3 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) extrinsic component of endosome membrane(GO:0031313) |
| 1.9 | 7.5 | GO:0000811 | GINS complex(GO:0000811) |
| 1.8 | 45.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 1.8 | 12.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 1.6 | 11.3 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 1.6 | 20.5 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 1.4 | 5.6 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 1.4 | 6.8 | GO:0031673 | H zone(GO:0031673) |
| 1.4 | 13.5 | GO:0070552 | BRISC complex(GO:0070552) |
| 1.3 | 14.2 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.3 | 1.3 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 1.2 | 5.9 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.1 | 8.0 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 1.0 | 10.1 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.8 | 18.7 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
| 0.8 | 7.6 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.8 | 5.9 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.8 | 3.2 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.8 | 17.7 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.8 | 2.3 | GO:0008623 | CHRAC(GO:0008623) |
| 0.7 | 29.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.7 | 10.9 | GO:0032059 | bleb(GO:0032059) |
| 0.7 | 6.5 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.7 | 11.3 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.7 | 7.9 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.6 | 3.2 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.6 | 12.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.6 | 4.8 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.6 | 41.4 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.6 | 12.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.6 | 2.9 | GO:0033503 | HULC complex(GO:0033503) |
| 0.6 | 4.6 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.6 | 5.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.6 | 1.7 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.5 | 8.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.5 | 1.6 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.5 | 5.3 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.5 | 4.7 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.5 | 6.8 | GO:0010369 | chromocenter(GO:0010369) |
| 0.5 | 1.6 | GO:0097179 | IPAF inflammasome complex(GO:0072557) protease inhibitor complex(GO:0097179) |
| 0.5 | 11.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.4 | 5.4 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.4 | 2.0 | GO:0042825 | TAP complex(GO:0042825) |
| 0.4 | 7.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.4 | 5.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.4 | 3.1 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 0.4 | 22.8 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.4 | 5.8 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.4 | 3.9 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.4 | 10.2 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.4 | 6.0 | GO:0008091 | spectrin(GO:0008091) |
| 0.3 | 7.3 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.3 | 2.0 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.3 | 3.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.3 | 1.6 | GO:0032807 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
| 0.3 | 12.7 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 0.3 | 2.8 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.3 | 6.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 1.4 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.3 | 4.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.3 | 3.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.3 | 15.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.3 | 0.8 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.3 | 3.9 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.3 | 5.4 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.3 | 1.5 | GO:0098576 | lumenal side of membrane(GO:0098576) |
| 0.3 | 48.4 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.2 | 4.9 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.2 | 25.3 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 7.8 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.2 | 0.6 | GO:0061202 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
| 0.2 | 4.7 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 1.9 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.2 | 3.0 | GO:0097433 | dense body(GO:0097433) |
| 0.2 | 4.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.2 | 5.8 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.2 | 3.5 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.2 | 1.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664) |
| 0.2 | 12.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 2.1 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.2 | 3.1 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.2 | 4.0 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.2 | 19.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 6.8 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.2 | 2.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.2 | 13.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.2 | 9.3 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 12.8 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 8.9 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 26.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.1 | 4.4 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.1 | 12.8 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 13.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 11.3 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.1 | 1.1 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 7.1 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 16.9 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 4.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 1.2 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 1.0 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 8.8 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 4.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 5.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 42.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 0.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 13.3 | GO:0005840 | ribosome(GO:0005840) |
| 0.1 | 2.2 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 6.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 4.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 1.0 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 1.2 | GO:1902562 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 0.2 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 0.6 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 3.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 2.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.5 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 2.8 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 13.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.3 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 3.7 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.4 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 1.1 | GO:0016514 | SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564) |
| 0.0 | 1.1 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 3.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 5.9 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 1.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 2.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.2 | GO:0005719 | nuclear euchromatin(GO:0005719) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.3 | 22.0 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 5.2 | 15.5 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 4.3 | 25.6 | GO:0034046 | poly(G) binding(GO:0034046) |
| 4.1 | 12.4 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 3.8 | 15.3 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 3.4 | 17.0 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 3.2 | 22.5 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 2.3 | 11.3 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 2.2 | 61.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.2 | 6.5 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
| 2.1 | 14.8 | GO:0102345 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 2.1 | 10.4 | GO:0047280 | nicotinamide phosphoribosyltransferase activity(GO:0047280) |
| 2.0 | 10.1 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 2.0 | 24.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.9 | 42.4 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 1.9 | 23.0 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 1.8 | 5.4 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 1.8 | 5.3 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 1.7 | 24.4 | GO:0031386 | protein tag(GO:0031386) |
| 1.7 | 46.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 1.6 | 4.9 | GO:0070336 | flap-structured DNA binding(GO:0070336) |
| 1.6 | 11.2 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 1.5 | 4.6 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 1.5 | 4.4 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 1.4 | 10.1 | GO:0000295 | adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217) |
| 1.3 | 6.7 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 1.2 | 10.9 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 1.2 | 9.4 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 1.1 | 11.3 | GO:0051425 | PTB domain binding(GO:0051425) |
| 1.1 | 3.3 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
| 1.1 | 6.5 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 1.1 | 15.8 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 1.0 | 4.2 | GO:0033265 | acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265) |
| 1.0 | 9.1 | GO:0043426 | MRF binding(GO:0043426) |
| 1.0 | 16.0 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 1.0 | 4.9 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.9 | 25.6 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.9 | 16.9 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.9 | 2.8 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.9 | 6.5 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.9 | 39.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.9 | 3.6 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.9 | 6.9 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.9 | 4.3 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.8 | 2.5 | GO:0061752 | telomeric repeat-containing RNA binding(GO:0061752) |
| 0.8 | 3.3 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.8 | 38.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.8 | 2.3 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.7 | 11.2 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.7 | 6.6 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.7 | 12.4 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.7 | 3.6 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.7 | 9.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.7 | 11.4 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.7 | 2.7 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.7 | 25.2 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.7 | 5.9 | GO:0089720 | caspase binding(GO:0089720) |
| 0.6 | 16.7 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.6 | 10.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.6 | 2.4 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.6 | 6.0 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.6 | 16.3 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.6 | 3.3 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.6 | 2.2 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.5 | 2.1 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.5 | 2.1 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.5 | 1.1 | GO:0008309 | double-stranded DNA exodeoxyribonuclease activity(GO:0008309) |
| 0.5 | 1.5 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.5 | 9.2 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.5 | 9.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.5 | 20.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.5 | 11.7 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.5 | 5.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.5 | 14.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.5 | 4.3 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.5 | 2.3 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.4 | 8.4 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.4 | 1.3 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 0.4 | 2.6 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.4 | 9.0 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.4 | 22.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 16.3 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.4 | 9.1 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.4 | 6.2 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.4 | 11.3 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.4 | 8.3 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.4 | 1.5 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.4 | 14.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.4 | 3.3 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.4 | 5.8 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.4 | 13.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.3 | 2.4 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.3 | 4.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.3 | 10.5 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.3 | 5.2 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.3 | 5.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.3 | 7.6 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.3 | 5.0 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.3 | 8.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.3 | 0.9 | GO:0001601 | peptide YY receptor activity(GO:0001601) |
| 0.3 | 3.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.3 | 15.7 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.3 | 2.6 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.3 | 1.4 | GO:0015639 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.3 | 4.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.3 | 3.5 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.3 | 25.1 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.3 | 2.1 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.3 | 3.0 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.2 | 1.7 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.2 | 7.7 | GO:0001848 | complement binding(GO:0001848) |
| 0.2 | 1.5 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.2 | 1.7 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.2 | 0.7 | GO:0004980 | melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.2 | 15.7 | GO:0008235 | metalloexopeptidase activity(GO:0008235) |
| 0.2 | 14.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 1.7 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.2 | 2.3 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.2 | 2.5 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.2 | 7.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 2.8 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.2 | 9.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 2.4 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.2 | 87.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 15.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 0.9 | GO:0008948 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948) |
| 0.2 | 6.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 2.1 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.2 | 14.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 10.7 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.1 | 7.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 5.3 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 0.9 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.1 | 3.2 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.1 | 11.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 2.3 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.1 | 3.1 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 14.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 0.9 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.1 | 2.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.4 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.1 | 2.4 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 15.1 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.1 | 1.1 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.1 | 0.1 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.1 | 1.6 | GO:0036122 | BMP binding(GO:0036122) |
| 0.1 | 0.6 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
| 0.1 | 2.9 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 1.3 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 8.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.1 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 2.6 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 1.7 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 7.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 1.3 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 4.0 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 0.6 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.1 | 25.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 1.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 1.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 5.1 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.1 | 2.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 1.6 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 0.7 | GO:0051378 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.1 | 1.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 2.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 1.2 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.1 | 6.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 1.2 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.1 | 2.0 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.1 | 2.1 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.7 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.3 | GO:0038064 | protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064) |
| 0.0 | 0.8 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 2.9 | GO:0008238 | exopeptidase activity(GO:0008238) |
| 0.0 | 3.1 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.0 | 1.4 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 10.7 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 1.4 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 6.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.6 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.0 | 11.1 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.0 | 0.1 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.0 | 3.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.9 | GO:0008186 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.0 | 1.5 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.0 | 0.9 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.5 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 3.8 | GO:0003779 | actin binding(GO:0003779) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 87.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 1.0 | 13.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.8 | 15.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.6 | 68.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.6 | 24.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.6 | 34.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 5.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.5 | 7.7 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.4 | 16.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.4 | 22.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.4 | 7.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.4 | 6.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.3 | 18.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.3 | 16.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.3 | 26.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.3 | 27.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 8.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.3 | 9.6 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.3 | 11.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.3 | 21.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 10.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 16.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.3 | 4.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.3 | 7.5 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.3 | 12.0 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.3 | 4.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 10.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 6.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 4.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 7.4 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.2 | 8.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.2 | 1.8 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.2 | 10.0 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.2 | 5.3 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.2 | 7.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 7.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 9.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 12.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 7.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 8.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.6 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 2.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 1.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 4.5 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 1.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 2.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 1.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 3.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 2.1 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 3.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.4 | PID CDC42 PATHWAY | CDC42 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 41.1 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 1.5 | 50.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 1.2 | 83.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 1.0 | 4.0 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.9 | 17.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.9 | 15.5 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.7 | 5.4 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.7 | 16.3 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.7 | 67.8 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.6 | 12.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.6 | 4.7 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.6 | 8.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.6 | 13.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.5 | 15.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.5 | 18.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.5 | 32.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.5 | 21.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.5 | 25.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.5 | 1.1 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.5 | 33.8 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.5 | 13.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.5 | 3.3 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.5 | 6.4 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.5 | 3.6 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.4 | 12.1 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.4 | 17.6 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.4 | 9.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.4 | 34.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 18.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 41.0 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.3 | 5.4 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.3 | 5.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.3 | 10.1 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.3 | 5.8 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.3 | 8.8 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.3 | 7.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 3.5 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.2 | 7.3 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.2 | 11.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 10.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.2 | 9.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 4.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.2 | 5.6 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.2 | 3.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 11.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 12.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.2 | 5.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 4.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 4.2 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 2.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 4.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.2 | 16.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 2.4 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 3.8 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 4.8 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 2.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 8.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.1 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 2.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 7.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 16.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 1.6 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 3.4 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 9.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 6.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 2.1 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 2.3 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 2.2 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 0.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 0.5 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 0.7 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 1.4 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 1.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.8 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 1.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.9 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 4.4 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.0 | 0.4 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 1.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.3 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.5 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |