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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for IRX2

Z-value: 2.50

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Transcription factors associated with IRX2

Gene Symbol Gene ID Gene Info
IRX2
ENSG00000170561.13 IRX2

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_58353069 14.07 ENST00000580947.1
SUPT4H1
SPT4 homolog, DSIF elongation factor subunit
chr5_+_168486462 9.54 ENST00000231572.8
ENST00000626454.1
RARS1
arginyl-tRNA synthetase 1
chr2_+_27628996 9.02 ENST00000616939.4
ENST00000264718.7
ENST00000610189.2
GPN1
GPN-loop GTPase 1
chr6_+_24774925 8.58 ENST00000356509.7
ENST00000230056.8
GMNN
geminin DNA replication inhibitor
chr12_-_102120065 8.26 ENST00000552283.6
ENST00000551744.2
NUP37
nucleoporin 37
chr7_+_16661182 7.97 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
BZW2
basic leucine zipper and W2 domains 2
chr3_-_185923893 7.84 ENST00000259043.11
TRA2B
transformer 2 beta homolog
chr18_-_36122110 7.22 ENST00000586829.1
SLC39A6
solute carrier family 39 member 6
chr17_+_36486629 6.67 ENST00000619730.4
ZNHIT3
zinc finger HIT-type containing 3
chr4_-_70839343 6.26 ENST00000514161.5
ENST00000499044.6
GRSF1
G-rich RNA sequence binding factor 1
chrX_+_19355582 5.90 ENST00000379804.1
PDHA1
pyruvate dehydrogenase E1 subunit alpha 1
chr17_+_36486668 5.83 ENST00000617429.5
ENST00000620324.4
ENST00000616269.1
ZNHIT3
zinc finger HIT-type containing 3
chr13_-_23433676 5.75 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
SACS
sacsin molecular chaperone
chr4_+_87975667 5.66 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
SPP1
secreted phosphoprotein 1
chr1_-_8879170 4.78 ENST00000489867.2
ENO1
enolase 1
chr19_-_39846329 4.36 ENST00000599134.1
ENST00000597634.5
ENST00000598417.5
ENST00000601274.5
ENST00000594309.5
ENST00000221801.8
FBL
fibrillarin
chr7_-_5959083 4.10 ENST00000539903.5
RSPH10B
radial spoke head 10 homolog B
chr16_+_67570741 3.95 ENST00000644753.1
ENST00000642819.1
ENST00000645306.1
CTCF
CCCTC-binding factor
chr12_+_109098118 3.67 ENST00000336865.6
UNG
uracil DNA glycosylase
chr5_-_143434677 3.50 ENST00000504572.5
NR3C1
nuclear receptor subfamily 3 group C member 1
chr7_+_150368189 3.47 ENST00000519397.1
ENST00000479668.5
REPIN1
replication initiator 1
chr1_+_158930778 3.44 ENST00000458222.5
PYHIN1
pyrin and HIN domain family member 1
chr16_-_69339493 3.34 ENST00000562595.5
ENST00000615447.1
ENST00000306875.10
ENST00000562081.2
COG8
component of oligomeric golgi complex 8
chr17_-_5419647 3.33 ENST00000573584.6
NUP88
nucleoporin 88
chr3_-_58433810 2.99 ENST00000474765.1
ENST00000485460.5
ENST00000302746.11
ENST00000383714.8
PDHB
pyruvate dehydrogenase E1 subunit beta
chr18_+_22933819 2.91 ENST00000399722.6
ENST00000399725.6
ENST00000399721.6
RBBP8
RB binding protein 8, endonuclease
chr6_+_4706133 2.87 ENST00000328908.9
CDYL
chromodomain Y like
chr17_+_35844077 2.83 ENST00000604694.1
TAF15
TATA-box binding protein associated factor 15
chr7_+_95485898 2.57 ENST00000428113.5
ASB4
ankyrin repeat and SOCS box containing 4
chr16_-_2264221 2.33 ENST00000566397.5
RNPS1
RNA binding protein with serine rich domain 1
chr19_+_18559000 2.31 ENST00000602094.5
KXD1
KxDL motif containing 1
chr5_-_88731827 2.27 ENST00000627170.2
MEF2C
myocyte enhancer factor 2C
chr7_+_100088957 2.25 ENST00000303904.8
ENST00000419210.1
ENST00000418625.5
COPS6
COP9 signalosome subunit 6
chr13_-_40982880 2.25 ENST00000635415.1
ELF1
E74 like ETS transcription factor 1
chr2_-_46617020 2.16 ENST00000474980.1
ENST00000281382.11
ENST00000306465.8
PIGF
phosphatidylinositol glycan anchor biosynthesis class F
chr14_-_100375333 2.13 ENST00000557297.5
ENST00000555813.5
ENST00000392882.7
ENST00000557135.5
ENST00000556698.5
ENST00000554509.5
ENST00000555410.5
WARS1
tryptophanyl-tRNA synthetase 1
chr2_+_108588286 2.12 ENST00000332345.10
LIMS1
LIM zinc finger domain containing 1
chr1_-_206023889 2.11 ENST00000358184.7
ENST00000360218.3
ENST00000678712.1
ENST00000678498.1
CTSE
cathepsin E
chr2_+_63842325 2.08 ENST00000445915.6
ENST00000475462.5
UGP2
UDP-glucose pyrophosphorylase 2
chr14_-_75069478 2.02 ENST00000555463.1
ACYP1
acylphosphatase 1
chr2_+_233729042 2.02 ENST00000482026.6
UGT1A3
UDP glucuronosyltransferase family 1 member A3
chr4_-_152411734 1.97 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7
chr11_+_62880885 1.96 ENST00000541372.1
ENST00000539458.1
ENST00000338663.12
ENST00000681232.1
ENST00000681657.1
SLC3A2
solute carrier family 3 member 2
chr11_+_62880863 1.89 ENST00000680297.1
SLC3A2
solute carrier family 3 member 2
chr2_-_70293438 1.89 ENST00000482975.6
ENST00000438261.5
SNRPG
small nuclear ribonucleoprotein polypeptide G
chr9_-_35079923 1.87 ENST00000378643.8
ENST00000448890.1
FANCG
FA complementation group G
chr12_-_123272234 1.65 ENST00000544658.5
CDK2AP1
cyclin dependent kinase 2 associated protein 1
chr17_-_3691887 1.58 ENST00000552050.5
P2RX5
purinergic receptor P2X 5
chr21_-_14658812 1.57 ENST00000647101.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr4_-_167234552 1.52 ENST00000512648.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr3_-_123980727 1.51 ENST00000620893.4
ROPN1
rhophilin associated tail protein 1
chr1_-_156728388 1.46 ENST00000313146.10
ISG20L2
interferon stimulated exonuclease gene 20 like 2
chr6_+_13272709 1.37 ENST00000379335.8
PHACTR1
phosphatase and actin regulator 1
chr1_+_74235377 1.34 ENST00000326637.8
TNNI3K
TNNI3 interacting kinase
chr7_+_107044689 1.34 ENST00000265717.5
PRKAR2B
protein kinase cAMP-dependent type II regulatory subunit beta
chr5_-_150758497 1.28 ENST00000521533.1
ENST00000424236.5
DCTN4
dynactin subunit 4
chr2_+_190927649 1.24 ENST00000409428.5
ENST00000409215.5
GLS
glutaminase
chr7_-_151080833 1.22 ENST00000353841.6
ENST00000482571.2
FASTK
Fas activated serine/threonine kinase
chr13_+_102656933 1.22 ENST00000650757.1
TPP2
tripeptidyl peptidase 2
chrX_-_119605870 1.09 ENST00000542113.3
NKRF
NFKB repressing factor
chr1_-_206921987 1.02 ENST00000530505.1
ENST00000442471.4
FCMR
Fc fragment of IgM receptor
chr15_-_79971164 0.95 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2A1
BCL2 related protein A1
chr4_+_68815991 0.93 ENST00000265403.12
ENST00000458688.2
UGT2B10
UDP glucuronosyltransferase family 2 member B10
chr7_-_151080787 0.92 ENST00000540185.5
ENST00000297532.11
FASTK
Fas activated serine/threonine kinase
chr6_-_136526472 0.88 ENST00000454590.5
ENST00000432797.6
MAP7
microtubule associated protein 7
chr14_+_23321446 0.82 ENST00000216727.9
ENST00000397276.6
PABPN1
poly(A) binding protein nuclear 1
chr15_-_19988117 0.81 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr15_+_57706725 0.81 ENST00000380557.4
ENST00000649091.1
POLR2M
RNA polymerase II subunit M
chr4_-_167234579 0.79 ENST00000502330.5
ENST00000357154.7
ENST00000421836.6
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr16_+_56865202 0.78 ENST00000566786.5
ENST00000438926.6
ENST00000563236.6
ENST00000262502.5
SLC12A3
solute carrier family 12 member 3
chr6_-_111605859 0.78 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr2_+_27148997 0.75 ENST00000296096.6
TCF23
transcription factor 23
chr4_-_167234426 0.75 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr6_-_27873525 0.74 ENST00000618305.2
H4C13
H4 clustered histone 13
chr6_-_136526177 0.73 ENST00000617204.4
MAP7
microtubule associated protein 7
chr16_-_4351283 0.73 ENST00000318059.8
PAM16
presequence translocase associated motor 16
chr10_-_59362460 0.71 ENST00000422313.6
ENST00000435852.6
ENST00000614220.4
ENST00000618804.5
ENST00000621119.4
FAM13C
family with sequence similarity 13 member C
chr12_+_75481204 0.70 ENST00000550491.1
GLIPR1
GLI pathogenesis related 1
chr2_-_165203870 0.68 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr9_-_13175824 0.65 ENST00000545857.5
MPDZ
multiple PDZ domain crumbs cell polarity complex component
chr6_-_136526654 0.65 ENST00000611373.1
MAP7
microtubule associated protein 7
chr21_-_44801813 0.64 ENST00000345496.7
UBE2G2
ubiquitin conjugating enzyme E2 G2
chr16_+_82035245 0.64 ENST00000199936.9
HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
chr1_-_206921867 0.63 ENST00000628511.2
ENST00000367091.8
FCMR
Fc fragment of IgM receptor
chr6_-_22302826 0.61 ENST00000651245.1
PRL
prolactin
chr4_-_69214743 0.59 ENST00000446444.2
UGT2B11
UDP glucuronosyltransferase family 2 member B11
chr9_-_21217311 0.59 ENST00000380216.1
IFNA16
interferon alpha 16
chr14_-_24508251 0.59 ENST00000250378.7
ENST00000206446.4
CMA1
chymase 1
chr3_-_11604452 0.58 ENST00000413604.5
VGLL4
vestigial like family member 4
chr1_+_15756659 0.55 ENST00000375771.5
FBLIM1
filamin binding LIM protein 1
chr2_+_137964279 0.55 ENST00000329366.8
HNMT
histamine N-methyltransferase
chr1_+_152719522 0.54 ENST00000368775.3
C1orf68
chromosome 1 open reading frame 68
chr2_-_165204042 0.54 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr1_-_149812359 0.52 ENST00000369167.2
ENST00000545683.1
H2BC18
H2B clustered histone 18
chr9_+_137086857 0.52 ENST00000682881.1
ENST00000683324.1
ENST00000542372.2
ENST00000683355.1
ENST00000682117.1
ENST00000682212.1
ENST00000684144.1
ENST00000683987.1
ENST00000371589.9
ENST00000535144.6
ENST00000475449.7
ENST00000684759.1
MAN1B1
mannosidase alpha class 1B member 1
chrX_+_136536099 0.50 ENST00000440515.5
ENST00000456412.1
VGLL1
vestigial like family member 1
chr4_-_167234266 0.48 ENST00000511269.5
ENST00000506697.5
ENST00000512042.1
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr5_+_157269317 0.46 ENST00000618329.4
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr9_+_76459152 0.46 ENST00000444201.6
ENST00000376730.5
GCNT1
glucosaminyl (N-acetyl) transferase 1
chr5_-_83720813 0.44 ENST00000515590.1
ENST00000274341.9
HAPLN1
hyaluronan and proteoglycan link protein 1
chr10_+_99782628 0.43 ENST00000648689.1
ENST00000647814.1
ABCC2
ATP binding cassette subfamily C member 2
chr6_-_136525961 0.42 ENST00000438100.6
MAP7
microtubule associated protein 7
chr3_-_197260369 0.42 ENST00000658155.1
ENST00000453607.5
DLG1
discs large MAGUK scaffold protein 1
chr14_-_64823148 0.41 ENST00000389722.7
SPTB
spectrin beta, erythrocytic
chr5_-_95081482 0.41 ENST00000312216.12
ENST00000512425.5
ENST00000505208.5
ENST00000429576.6
ENST00000508509.5
ENST00000510732.5
MCTP1
multiple C2 and transmembrane domain containing 1
chr22_-_28306645 0.40 ENST00000612946.4
TTC28
tetratricopeptide repeat domain 28
chr7_+_72925075 0.38 ENST00000434423.5
POM121
POM121 transmembrane nucleoporin
chr16_+_68644988 0.35 ENST00000429102.6
CDH3
cadherin 3
chr4_+_118685373 0.34 ENST00000388822.10
ENST00000508801.1
METTL14
methyltransferase like 14
chr6_-_53148822 0.33 ENST00000259803.8
GCM1
glial cells missing transcription factor 1
chr14_-_64942783 0.30 ENST00000612794.1
GPX2
glutathione peroxidase 2
chr10_-_95069489 0.30 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
CYP2C8
cytochrome P450 family 2 subfamily C member 8
chr21_+_42403874 0.29 ENST00000319294.11
ENST00000398367.1
UBASH3A
ubiquitin associated and SH3 domain containing A
chr4_+_186266183 0.29 ENST00000403665.7
ENST00000492972.6
ENST00000264692.8
F11
coagulation factor XI
chr8_+_24294107 0.28 ENST00000437154.6
ADAM28
ADAM metallopeptidase domain 28
chr8_+_80485641 0.25 ENST00000430430.5
ZBTB10
zinc finger and BTB domain containing 10
chr17_-_27800524 0.16 ENST00000313735.11
NOS2
nitric oxide synthase 2
chr20_+_18507520 0.12 ENST00000336714.8
ENST00000646240.1
ENST00000450074.6
ENST00000262544.6
SEC23B
SEC23 homolog B, COPII coat complex component
chr11_+_60056653 0.11 ENST00000278865.8
MS4A3
membrane spanning 4-domains A3
chr20_+_45221362 0.10 ENST00000372769.4
SEMG2
semenogelin 2
chr2_+_46617180 0.08 ENST00000238892.4
CRIPT
CXXC repeat containing interactor of PDZ3 domain
chr18_+_52752032 0.08 ENST00000412726.5
ENST00000578080.1
ENST00000582875.1
DCC
DCC netrin 1 receptor
chrX_-_100874209 0.08 ENST00000372964.5
ENST00000217885.5
NOX1
NADPH oxidase 1
chr4_-_69639642 0.06 ENST00000604629.6
ENST00000604021.1
UGT2A2
UDP glucuronosyltransferase family 2 member A2
chr7_-_14841267 0.04 ENST00000406247.7
ENST00000399322.7
DGKB
diacylglycerol kinase beta
chr1_-_157841800 0.03 ENST00000368174.5
CD5L
CD5 molecule like
chr16_+_7332744 0.03 ENST00000436368.6
ENST00000311745.9
ENST00000340209.8
ENST00000620507.4
RBFOX1
RNA binding fox-1 homolog 1
chr1_-_158554405 0.03 ENST00000641282.1
ENST00000641622.1
OR6Y1
olfactory receptor family 6 subfamily Y member 1
chr2_+_170178136 0.02 ENST00000409044.7
ENST00000408978.9
MYO3B
myosin IIIB
chr16_+_58392462 0.01 ENST00000318129.6
GINS3
GINS complex subunit 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.0 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
1.9 5.7 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
1.7 8.6 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
1.5 4.4 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.9 8.9 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.9 14.1 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.8 7.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.8 4.0 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.6 3.9 GO:0060356 leucine import(GO:0060356)
0.6 7.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.5 2.0 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.4 4.8 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.4 2.9 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.4 3.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.3 2.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065) glucose 1-phosphate metabolic process(GO:0019255)
0.3 5.8 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.3 3.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 2.3 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.3 3.7 GO:0045008 depyrimidination(GO:0045008)
0.3 0.8 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.2 1.3 GO:0097338 response to clozapine(GO:0097338)
0.2 1.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 0.6 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.2 8.6 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 0.5 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.2 2.0 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 0.8 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.2 2.3 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.4 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.1 2.1 GO:0016540 protein autoprocessing(GO:0016540)
0.1 2.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 0.3 GO:0048817 negative regulation of transforming growth factor beta2 production(GO:0032912) negative regulation of hair follicle maturation(GO:0048817) regulation of melanosome transport(GO:1902908)
0.1 0.3 GO:0060018 astrocyte fate commitment(GO:0060018)
0.1 2.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.3 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.1 6.3 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1 1.9 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 2.3 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 1.3 GO:0007097 nuclear migration(GO:0007097)
0.1 2.3 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 1.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.1 0.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.5 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 3.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.6 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 2.1 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.3 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.6 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.6 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.3 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 1.5 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.5 GO:0060352 cell adhesion molecule production(GO:0060352)
0.0 1.6 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 1.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.4 GO:0051660 establishment of centrosome localization(GO:0051660) regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.0 0.6 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 1.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 2.3 GO:0032418 lysosome localization(GO:0032418)
0.0 1.2 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 1.6 GO:0006968 cellular defense response(GO:0006968)
0.0 2.2 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.2 GO:0032310 positive regulation of guanylate cyclase activity(GO:0031284) prostaglandin secretion(GO:0032310) positive regulation of killing of cells of other organism(GO:0051712)
0.0 4.9 GO:0006260 DNA replication(GO:0006260)
0.0 1.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 14.1 GO:0032044 DSIF complex(GO:0032044)
0.9 4.4 GO:0001651 dense fibrillar component(GO:0001651) granular component(GO:0001652)
0.7 8.9 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.6 4.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.6 5.8 GO:0070852 cell body fiber(GO:0070852)
0.5 8.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 3.5 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 2.0 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.3 1.9 GO:0005683 U7 snRNP(GO:0005683)
0.3 2.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 3.3 GO:0017119 Golgi transport complex(GO:0017119)
0.2 2.3 GO:0061574 ASAP complex(GO:0061574)
0.2 0.7 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 1.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 7.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 2.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 6.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 9.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.3 GO:0005869 dynactin complex(GO:0005869)
0.1 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.3 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 1.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.4 GO:0008091 spectrin(GO:0008091)
0.0 2.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 3.3 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.0 0.7 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.4 GO:0043219 lateral loop(GO:0043219)
0.0 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.7 GO:0005875 microtubule associated complex(GO:0005875)
0.0 4.0 GO:0000793 condensed chromosome(GO:0000793)
0.0 8.6 GO:0016607 nuclear speck(GO:0016607)
0.0 5.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 6.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.7 GO:0035577 azurophil granule membrane(GO:0035577)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.9 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
1.3 4.0 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.7 2.2 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.7 3.5 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.6 4.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 2.1 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.4 14.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.4 3.7 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.3 7.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 2.0 GO:0003998 acylphosphatase activity(GO:0003998)
0.3 2.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.3 3.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.3 4.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 12.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.2 2.0 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 1.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 0.6 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.2 1.2 GO:0004359 glutaminase activity(GO:0004359)
0.2 3.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.5 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.2 4.1 GO:0070628 proteasome binding(GO:0070628)
0.2 7.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.3 GO:0031013 troponin I binding(GO:0031013)
0.1 2.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 3.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 8.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 2.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 1.0 GO:0051400 BH domain binding(GO:0051400)
0.0 1.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.8 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 2.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 1.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.4 GO:0030506 ankyrin binding(GO:0030506)
0.0 9.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 6.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 8.0 GO:0045296 cadherin binding(GO:0045296)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 3.9 GO:0005125 cytokine activity(GO:0005125)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0070008 serine-type exopeptidase activity(GO:0070008)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 9.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 5.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 3.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 2.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 2.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.6 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.0 PID BCR 5PATHWAY BCR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.5 8.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.4 14.1 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.4 7.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 12.0 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2 5.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 1.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 2.9 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 4.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 2.3 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 2.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 0.8 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.1 2.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 5.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 6.3 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 3.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 3.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins