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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ISL2

Z-value: 3.85

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.10 ISL2

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_+_34993240 20.35 ENST00000677647.1
SRP54
signal recognition particle 54
chr2_-_10447771 16.87 ENST00000405333.5
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr10_-_93482326 16.00 ENST00000359263.9
MYOF
myoferlin
chr8_-_63026179 15.88 ENST00000677919.1
GGH
gamma-glutamyl hydrolase
chr10_-_93482194 15.62 ENST00000358334.9
ENST00000371488.3
MYOF
myoferlin
chr4_+_112647059 12.41 ENST00000511529.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr7_+_16661182 11.29 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
BZW2
basic leucine zipper and W2 domains 2
chr11_-_107858777 11.23 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr3_-_142029108 10.35 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr13_+_30422487 10.14 ENST00000638137.1
ENST00000635918.2
UBE2L5
ubiquitin conjugating enzyme E2 L5
chr9_+_69145463 9.44 ENST00000636438.1
TJP2
tight junction protein 2
chr17_-_8210203 9.16 ENST00000578549.5
ENST00000582368.5
AURKB
aurora kinase B
chr1_-_225428813 8.91 ENST00000338179.6
ENST00000425080.1
LBR
lamin B receptor
chr1_+_98661666 8.13 ENST00000529992.5
SNX7
sorting nexin 7
chr12_-_56741535 7.76 ENST00000647707.1
ENSG00000285625.1
novel protein
chr11_+_102112445 7.16 ENST00000524575.5
YAP1
Yes1 associated transcriptional regulator
chr3_+_136930469 6.36 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr12_+_64404338 6.08 ENST00000332707.10
XPOT
exportin for tRNA
chr4_+_168497066 5.98 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr11_-_28108109 5.91 ENST00000263181.7
KIF18A
kinesin family member 18A
chr4_+_168497044 5.81 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr7_-_16804987 5.79 ENST00000401412.5
ENST00000419304.7
AGR2
anterior gradient 2, protein disulphide isomerase family member
chr2_+_231056845 5.51 ENST00000677230.1
ENST00000677259.1
ENST00000677180.1
ENST00000409643.6
ENST00000619128.5
ENST00000678679.1
ENST00000676740.1
ENST00000308696.11
ENST00000440838.5
ENST00000373635.9
PSMD1
proteasome 26S subunit, non-ATPase 1
chr18_-_36798482 5.25 ENST00000590258.2
TPGS2
tubulin polyglutamylase complex subunit 2
chr2_-_135876382 5.19 ENST00000264156.3
MCM6
minichromosome maintenance complex component 6
chr11_-_95923763 5.00 ENST00000497683.6
ENST00000470293.6
ENST00000674968.1
ENST00000484818.6
ENST00000675454.1
ENST00000675981.1
ENST00000674924.1
ENST00000676166.1
ENST00000676440.1
ENST00000675807.1
ENST00000495134.6
ENST00000675196.1
MTMR2
myotubularin related protein 2
chr10_-_29634964 4.43 ENST00000375398.6
ENST00000355867.8
SVIL
supervillin
chr11_+_35186820 4.37 ENST00000531110.6
ENST00000525685.6
CD44
CD44 molecule (Indian blood group)
chr17_-_50707855 4.23 ENST00000285243.7
ANKRD40
ankyrin repeat domain 40
chr17_+_7252502 3.97 ENST00000570322.5
ENST00000576496.5
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5
chr12_+_75391078 3.62 ENST00000550916.6
ENST00000378692.7
ENST00000320460.8
ENST00000547164.1
GLIPR1L2
GLIPR1 like 2
chr9_-_14300231 3.38 ENST00000636735.1
NFIB
nuclear factor I B
chr15_+_64387828 3.31 ENST00000261884.8
TRIP4
thyroid hormone receptor interactor 4
chr22_-_28711931 3.09 ENST00000434810.5
ENST00000456369.5
CHEK2
checkpoint kinase 2
chr10_-_5003850 2.94 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
AKR1C2
aldo-keto reductase family 1 member C2
chr14_-_67412112 2.84 ENST00000216446.9
PLEK2
pleckstrin 2
chr19_+_3185911 2.80 ENST00000246117.9
ENST00000588428.5
NCLN
nicalin
chr2_+_233760265 2.78 ENST00000305208.10
ENST00000360418.4
UGT1A1
UDP glucuronosyltransferase family 1 member A1
chr11_-_95924067 2.77 ENST00000676027.1
ENST00000675489.1
ENST00000409459.5
ENST00000676261.1
ENST00000352297.11
ENST00000346299.10
ENST00000676272.1
ENST00000393223.8
ENST00000675022.1
ENST00000675362.1
ENST00000675174.1
ENST00000674989.1
ENST00000675848.1
ENST00000675652.1
ENST00000481642.6
MTMR2
myotubularin related protein 2
chr5_-_131165272 2.74 ENST00000675491.1
ENST00000506908.2
HINT1
histidine triad nucleotide binding protein 1
chr5_-_140346596 2.73 ENST00000230990.7
HBEGF
heparin binding EGF like growth factor
chr15_+_48191648 2.62 ENST00000646012.1
ENST00000561127.5
ENST00000647546.1
ENST00000559641.5
ENST00000417307.3
SLC12A1
CTXN2
solute carrier family 12 member 1
cortexin 2
chr1_-_94925759 2.52 ENST00000415017.1
ENST00000545882.5
CNN3
calponin 3
chr15_+_78873723 2.40 ENST00000559690.5
ENST00000559158.5
MORF4L1
mortality factor 4 like 1
chr4_+_26343156 2.37 ENST00000680928.1
ENST00000681260.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chrX_-_101617921 2.36 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
ARMCX6
armadillo repeat containing X-linked 6
chr4_+_127781815 2.30 ENST00000508776.5
HSPA4L
heat shock protein family A (Hsp70) member 4 like
chr6_-_111483700 2.25 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr20_-_35147285 2.23 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chrX_-_85379659 2.19 ENST00000262753.9
POF1B
POF1B actin binding protein
chr5_-_131165231 2.16 ENST00000675100.1
ENST00000304043.10
ENST00000513012.2
HINT1
histidine triad nucleotide binding protein 1
chr7_-_24757926 2.15 ENST00000342947.9
ENST00000419307.6
GSDME
gasdermin E
chr7_-_45111673 2.14 ENST00000461363.1
ENST00000258770.8
ENST00000495078.1
ENST00000494076.5
ENST00000478532.5
ENST00000361278.7
TBRG4
transforming growth factor beta regulator 4
chr12_+_26011713 2.08 ENST00000542004.5
RASSF8
Ras association domain family member 8
chr8_+_69492793 2.08 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
SULF1
sulfatase 1
chr14_-_50561119 2.05 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr11_-_63608542 2.04 ENST00000540943.1
PLAAT3
phospholipase A and acyltransferase 3
chr9_+_12693327 1.93 ENST00000388918.10
TYRP1
tyrosinase related protein 1
chrX_+_109535775 1.89 ENST00000218004.5
NXT2
nuclear transport factor 2 like export factor 2
chr14_+_101809795 1.77 ENST00000350249.7
ENST00000557621.5
ENST00000556946.1
PPP2R5C
protein phosphatase 2 regulatory subunit B'gamma
chr2_-_162152404 1.67 ENST00000375497.3
GCG
glucagon
chr1_-_21050952 1.59 ENST00000264211.12
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chr6_+_151239951 1.55 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chr17_-_66229380 1.39 ENST00000205948.11
APOH
apolipoprotein H
chrX_+_103585478 1.34 ENST00000468024.5
ENST00000415568.2
ENST00000472484.6
ENST00000613326.4
ENST00000490644.5
ENST00000459722.1
ENST00000472745.1
ENST00000494801.5
ENST00000434216.2
TCEAL4
transcription elongation factor A like 4
chrX_-_77634229 1.26 ENST00000675732.1
ATRX
ATRX chromatin remodeler
chr7_-_116030750 1.23 ENST00000265440.12
ENST00000320239.11
TFEC
transcription factor EC
chr9_-_92404559 1.22 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr3_-_165078480 1.15 ENST00000264382.8
SI
sucrase-isomaltase
chr9_+_108862255 1.10 ENST00000333999.5
ACTL7A
actin like 7A
chr7_-_116030735 1.00 ENST00000393485.5
TFEC
transcription factor EC
chr1_-_175023408 1.00 ENST00000476371.1
MRPS14
mitochondrial ribosomal protein S14
chrX_-_31266925 0.96 ENST00000680557.1
ENST00000378680.6
ENST00000378723.7
ENST00000680768.2
ENST00000681870.1
ENST00000680355.1
ENST00000682322.1
ENST00000682600.1
ENST00000680162.2
ENST00000681153.1
ENST00000681334.1
DMD
dystrophin
chr2_+_233671879 0.92 ENST00000354728.5
UGT1A9
UDP glucuronosyltransferase family 1 member A9
chr17_-_10469558 0.79 ENST00000255381.2
MYH4
myosin heavy chain 4
chr17_-_3592877 0.72 ENST00000399756.8
TRPV1
transient receptor potential cation channel subfamily V member 1
chr20_-_52105644 0.64 ENST00000371523.8
ZFP64
ZFP64 zinc finger protein
chr6_-_155455830 0.62 ENST00000159060.3
NOX3
NADPH oxidase 3
chr5_+_154755272 0.54 ENST00000518297.6
LARP1
La ribonucleoprotein 1, translational regulator
chr19_-_45730861 0.36 ENST00000317683.4
FBXO46
F-box protein 46
chr17_-_7315312 0.34 ENST00000577040.2
ENST00000389167.9
ENST00000380728.7
GPS2
G protein pathway suppressor 2
chr12_-_51028234 0.34 ENST00000547688.7
ENST00000394904.9
SLC11A2
solute carrier family 11 member 2
chrX_-_31266857 0.33 ENST00000378702.8
ENST00000361471.8
DMD
dystrophin
chr1_-_113871665 0.27 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr2_-_162152239 0.24 ENST00000418842.7
GCG
glucagon
chr11_+_86374736 0.23 ENST00000354755.5
ENST00000531271.5
ENST00000445632.7
CCDC81
coiled-coil domain containing 81
chr1_+_117001744 0.19 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101
CD101 molecule
chr11_-_13495984 0.14 ENST00000282091.6
PTH
parathyroid hormone
chr1_-_13056575 0.11 ENST00000436041.6
PRAMEF27
PRAME family member 27
chr6_+_63635792 0.07 ENST00000262043.8
ENST00000506783.5
ENST00000481385.6
ENST00000515594.5
ENST00000494284.6
PHF3
PHD finger protein 3
chr4_-_121164314 0.07 ENST00000057513.8
TNIP3
TNFAIP3 interacting protein 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 20.4 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
4.0 15.9 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
3.4 16.9 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
3.1 9.2 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
2.1 6.4 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
2.1 31.6 GO:0001778 plasma membrane repair(GO:0001778)
1.2 9.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
1.2 5.8 GO:0060480 lung goblet cell differentiation(GO:0060480)
1.0 3.1 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.8 7.2 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.7 2.2 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.7 7.8 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.7 2.8 GO:0018879 biphenyl metabolic process(GO:0018879)
0.6 11.8 GO:0003334 keratinocyte development(GO:0003334)
0.5 2.9 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.5 1.9 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.4 1.3 GO:1904908 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.4 2.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.4 5.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 2.7 GO:0051541 elastin metabolic process(GO:0051541)
0.3 2.4 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.3 4.4 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 3.4 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 5.9 GO:0072520 seminiferous tubule development(GO:0072520)
0.2 10.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 1.9 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.2 2.1 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 0.5 GO:1901355 response to rapamycin(GO:1901355)
0.2 0.7 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.2 1.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 0.9 GO:0051552 flavone metabolic process(GO:0051552)
0.1 1.4 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 1.6 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 6.1 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 2.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 0.6 GO:0048840 otolith development(GO:0048840)
0.1 4.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 2.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 2.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 2.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 8.9 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 1.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 4.9 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.1 0.3 GO:0015692 lead ion transport(GO:0015692)
0.1 3.3 GO:1901998 toxin transport(GO:1901998)
0.1 5.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.3 GO:1902523 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 2.2 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 2.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 8.1 GO:0016050 vesicle organization(GO:0016050)
0.0 2.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 1.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.8 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 2.3 GO:0006986 response to unfolded protein(GO:0006986)
0.0 1.9 GO:0051028 mRNA transport(GO:0051028)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
2.3 20.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
1.8 5.5 GO:0034515 proteasome storage granule(GO:0034515)
1.0 9.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.5 5.9 GO:0005828 kinetochore microtubule(GO:0005828)
0.5 4.4 GO:0036449 microtubule minus-end(GO:0036449)
0.4 8.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.4 1.3 GO:0031933 telomeric heterochromatin(GO:0031933)
0.4 5.2 GO:0042555 MCM complex(GO:0042555)
0.4 4.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.4 6.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 4.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.3 2.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 31.6 GO:0005901 caveola(GO:0005901)
0.2 11.0 GO:0002102 podosome(GO:0002102)
0.2 2.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 15.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.2 3.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 2.4 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.9 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.1 GO:0016013 syntrophin complex(GO:0016013)
0.1 1.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.1 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 2.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 2.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.3 GO:0070826 paraferritin complex(GO:0070826)
0.1 11.6 GO:0005923 bicellular tight junction(GO:0005923)
0.1 4.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 10.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 10.3 GO:0043197 dendritic spine(GO:0043197)
0.0 6.1 GO:0005643 nuclear pore(GO:0005643)
0.0 1.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 3.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 2.7 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 1.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 3.0 GO:0016605 PML body(GO:0016605)
0.0 8.1 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 1.9 GO:0005795 Golgi stack(GO:0005795)
0.0 5.2 GO:0005874 microtubule(GO:0005874)
0.0 7.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.2 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 20.4 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
3.0 8.9 GO:0050613 delta14-sterol reductase activity(GO:0050613)
1.1 6.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
1.0 9.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.9 2.6 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.7 15.9 GO:0008242 omega peptidase activity(GO:0008242)
0.6 2.9 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.5 2.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 11.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.4 1.3 GO:0015616 DNA translocase activity(GO:0015616)
0.4 7.8 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 1.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.3 16.9 GO:0016831 carboxy-lyase activity(GO:0016831)
0.3 5.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 2.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3 6.9 GO:0002162 dystroglycan binding(GO:0002162)
0.2 1.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 7.2 GO:0070064 proline-rich region binding(GO:0070064)
0.2 9.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 2.4 GO:0000150 recombinase activity(GO:0000150)
0.1 0.7 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.1 4.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 6.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 2.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 5.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 3.7 GO:0001972 retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020)
0.1 3.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 2.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.1 GO:0000339 RNA cap binding(GO:0000339)
0.1 1.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 4.9 GO:0005080 protein kinase C binding(GO:0005080)
0.1 2.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.3 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 29.5 GO:0005543 phospholipid binding(GO:0005543)
0.1 2.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.8 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 1.3 GO:0050699 WW domain binding(GO:0050699)
0.0 11.3 GO:0045296 cadherin binding(GO:0045296)
0.0 5.9 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 12.6 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.0 1.4 GO:0047485 protein N-terminus binding(GO:0047485)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 38.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.2 9.2 PID AURORA A PATHWAY Aurora A signaling
0.1 9.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 16.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.1 PID ATM PATHWAY ATM pathway
0.1 10.3 PID E2F PATHWAY E2F transcription factor network
0.1 9.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.4 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.0 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 16.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.6 16.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.5 7.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 5.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 6.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 8.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 5.9 REACTOME KINESINS Genes involved in Kinesins
0.2 1.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 4.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 3.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 14.7 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 2.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 3.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 20.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 3.4 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.7 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.8 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 2.2 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 1.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes