Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for JUND

Z-value: 3.70

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Transcription factors associated with JUND

Gene Symbol Gene ID Gene Info
JUND
ENSG00000130522.6 JUND

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
JUNDhg38_v1_chr19_-_18280806_182809290.513.7e-16Click!

Activity profile of JUND motif

Sorted Z-values of JUND motif

Network of associatons between targets according to the STRING database.

First level regulatory network of JUND

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_18424533 22.90 ENST00000417717.6
SATB1
SATB homeobox 1
chr5_-_140633167 20.02 ENST00000302014.11
CD14
CD14 molecule
chr5_-_140633690 18.30 ENST00000512545.1
ENST00000401743.6
CD14
CD14 molecule
chr6_+_33075952 17.97 ENST00000418931.7
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr4_-_83114715 16.91 ENST00000426923.2
ENST00000311507.9
ENST00000509973.5
PLAC8
placenta associated 8
chr3_-_18425295 15.04 ENST00000338745.11
ENST00000450898.1
SATB1
SATB homeobox 1
chr21_+_41370452 14.56 ENST00000680862.1
MX2
MX dynamin like GTPase 2
chr7_-_36985060 11.96 ENST00000396040.6
ELMO1
engulfment and cell motility 1
chr1_-_153375591 11.69 ENST00000368737.5
S100A12
S100 calcium binding protein A12
chr1_+_116754422 10.02 ENST00000369478.4
ENST00000369477.1
CD2
CD2 molecule
chr15_+_88638947 9.81 ENST00000559876.2
ISG20
interferon stimulated exonuclease gene 20
chr19_+_13731744 9.44 ENST00000586600.5
CCDC130
coiled-coil domain containing 130
chr7_+_80369547 9.35 ENST00000435819.5
CD36
CD36 molecule
chr6_-_24935942 9.30 ENST00000645100.1
ENST00000643898.2
ENST00000613507.4
RIPOR2
RHO family interacting cell polarization regulator 2
chr15_+_88639009 9.08 ENST00000306072.10
ISG20
interferon stimulated exonuclease gene 20
chr21_+_41361999 8.57 ENST00000436410.5
ENST00000435611.6
ENST00000330714.8
MX2
MX dynamin like GTPase 2
chr3_+_46370854 8.46 ENST00000292303.4
CCR5
C-C motif chemokine receptor 5
chr6_-_41705813 8.23 ENST00000419574.6
ENST00000445214.2
TFEB
transcription factor EB
chr18_-_76495191 8.14 ENST00000443185.7
ZNF516
zinc finger protein 516
chr11_+_67483019 8.08 ENST00000279146.8
ENST00000528641.7
ENST00000682324.1
ENST00000684006.1
ENST00000683237.1
ENST00000684657.1
AIP
aryl hydrocarbon receptor interacting protein
chr16_+_31355215 7.50 ENST00000562522.2
ITGAX
integrin subunit alpha X
chr22_-_37149900 7.36 ENST00000216223.10
IL2RB
interleukin 2 receptor subunit beta
chr11_+_67483119 7.32 ENST00000682659.1
ENST00000525341.2
AIP
aryl hydrocarbon receptor interacting protein
chr14_-_95714088 6.99 ENST00000556450.5
TCL1A
TCL1 family AKT coactivator A
chr1_-_150765785 6.93 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
CTSS
cathepsin S
chr16_+_31355165 6.93 ENST00000562918.5
ENST00000268296.9
ITGAX
integrin subunit alpha X
chr5_-_141682211 6.64 ENST00000239440.9
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr14_+_58298497 6.62 ENST00000348476.7
ENST00000355431.8
ENST00000395168.7
ARID4A
AT-rich interaction domain 4A
chr12_-_8066331 6.48 ENST00000546241.1
ENST00000307637.5
C3AR1
complement C3a receptor 1
chr5_-_141682192 6.07 ENST00000508305.5
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr12_+_54497712 6.05 ENST00000293373.11
NCKAP1L
NCK associated protein 1 like
chr8_-_81447428 5.86 ENST00000256103.3
ENST00000519260.1
PMP2
peripheral myelin protein 2
chr9_-_70414657 5.66 ENST00000377126.4
KLF9
Kruppel like factor 9
chr3_-_122793772 5.55 ENST00000306103.3
HSPBAP1
HSPB1 associated protein 1
chr20_+_46008900 5.49 ENST00000372330.3
MMP9
matrix metallopeptidase 9
chr5_+_36606355 5.28 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
SLC1A3
solute carrier family 1 member 3
chr20_+_32358303 5.13 ENST00000651418.1
ENST00000375687.10
ENST00000542461.5
ENST00000613218.4
ENST00000646367.1
ENST00000620121.4
ASXL1
ASXL transcriptional regulator 1
chr9_+_4985227 4.92 ENST00000381652.4
JAK2
Janus kinase 2
chr11_-_2140967 4.58 ENST00000381389.5
IGF2
insulin like growth factor 2
chr3_+_138347648 4.38 ENST00000614350.4
ENST00000289104.8
MRAS
muscle RAS oncogene homolog
chr19_+_35329161 4.36 ENST00000341773.10
ENST00000600131.5
ENST00000595780.5
ENST00000597916.5
ENST00000593867.5
ENST00000600424.5
ENST00000599811.5
ENST00000536635.6
ENST00000085219.10
ENST00000544992.6
ENST00000419549.6
CD22
CD22 molecule
chr3_-_49358272 4.33 ENST00000419349.2
GPX1
glutathione peroxidase 1
chr12_+_62260338 4.33 ENST00000353364.7
ENST00000549523.5
USP15
ubiquitin specific peptidase 15
chr14_-_22957100 4.28 ENST00000555367.5
HAUS4
HAUS augmin like complex subunit 4
chr3_-_49358320 4.27 ENST00000643797.1
ENST00000646881.2
ENST00000496791.2
GPX1
glutathione peroxidase 1
chr16_+_28984795 4.24 ENST00000395461.7
LAT
linker for activation of T cells
chr1_+_160739239 4.18 ENST00000368043.8
SLAMF7
SLAM family member 7
chr8_+_84184875 4.13 ENST00000517638.5
ENST00000522647.1
RALYL
RALY RNA binding protein like
chr9_-_92670124 4.09 ENST00000287996.8
IPPK
inositol-pentakisphosphate 2-kinase
chr11_-_2141238 4.06 ENST00000434045.6
IGF2
insulin like growth factor 2
chr14_-_22957061 3.85 ENST00000557591.5
ENST00000541587.6
ENST00000490506.5
ENST00000554406.1
HAUS4
HAUS augmin like complex subunit 4
chr20_+_49812697 3.78 ENST00000417961.5
SLC9A8
solute carrier family 9 member A8
chrX_-_155334580 3.65 ENST00000369449.7
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr3_+_156142962 3.64 ENST00000471742.5
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr4_-_88158605 3.58 ENST00000237612.8
ABCG2
ATP binding cassette subfamily G member 2 (Junior blood group)
chr16_+_28985043 3.43 ENST00000395456.7
ENST00000564277.5
ENST00000630764.2
ENST00000354453.7
LAT
linker for activation of T cells
chr12_+_62260374 3.39 ENST00000312635.10
ENST00000280377.10
ENST00000549237.5
USP15
ubiquitin specific peptidase 15
chr14_-_22957128 3.28 ENST00000342454.12
ENST00000555986.5
ENST00000554516.5
ENST00000347758.6
ENST00000206474.11
ENST00000555040.5
HAUS4
HAUS augmin like complex subunit 4
chr8_-_27614681 3.27 ENST00000519472.5
ENST00000523589.5
ENST00000522413.5
ENST00000523396.1
ENST00000316403.15
CLU
clusterin
chr1_+_160739265 3.21 ENST00000368042.7
SLAMF7
SLAM family member 7
chr12_+_52301833 3.04 ENST00000293525.5
KRT86
keratin 86
chr4_+_70195719 3.03 ENST00000683306.1
ODAM
odontogenic, ameloblast associated
chr2_+_101998955 2.95 ENST00000393414.6
IL1R2
interleukin 1 receptor type 2
chr4_+_159241016 2.91 ENST00000644902.1
RAPGEF2
Rap guanine nucleotide exchange factor 2
chr19_-_54360949 2.89 ENST00000622064.1
LAIR1
leukocyte associated immunoglobulin like receptor 1
chr2_+_169069537 2.88 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
DHRS9
dehydrogenase/reductase 9
chr20_+_49812818 2.85 ENST00000361573.3
SLC9A8
solute carrier family 9 member A8
chr20_-_17558811 2.81 ENST00000536626.7
ENST00000377868.6
BFSP1
beaded filament structural protein 1
chr2_-_144517663 2.63 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
ZEB2
zinc finger E-box binding homeobox 2
chr18_-_21703688 2.59 ENST00000584464.1
ENST00000578270.5
ABHD3
abhydrolase domain containing 3, phospholipase
chr4_-_99435336 2.58 ENST00000437033.7
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr12_-_8612850 2.51 ENST00000229335.11
ENST00000537228.5
AICDA
activation induced cytidine deaminase
chr17_-_35063648 2.50 ENST00000394597.7
RFFL
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr14_+_22508602 2.41 ENST00000390504.1
TRAJ33
T cell receptor alpha joining 33
chr17_+_27471999 2.40 ENST00000583370.5
ENST00000509603.6
ENST00000268763.10
ENST00000398988.7
KSR1
kinase suppressor of ras 1
chr3_-_128052166 2.31 ENST00000648300.1
MGLL
monoglyceride lipase
chr4_-_99435396 2.24 ENST00000209665.8
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr12_+_8989535 2.22 ENST00000356986.8
KLRG1
killer cell lectin like receptor G1
chr3_-_46566276 2.22 ENST00000395905.8
LRRC2
leucine rich repeat containing 2
chr17_+_2033393 2.17 ENST00000570477.6
DPH1
diphthamide biosynthesis 1
chr1_+_223701607 2.16 ENST00000434648.5
CAPN2
calpain 2
chr16_+_15502266 2.16 ENST00000452191.6
BMERB1
bMERB domain containing 1
chr2_-_151973780 2.13 ENST00000637514.1
ENST00000636350.1
ENST00000434468.2
ENST00000637762.1
ENST00000637779.1
ENST00000637547.1
ENST00000636901.1
ENST00000397327.7
ENST00000636721.1
ENST00000636380.1
ENST00000637284.1
ENST00000636617.1
ENST00000636947.1
ENST00000638091.1
ENST00000636108.1
ENST00000638040.1
ENST00000636773.1
ENST00000637418.1
ENST00000637216.1
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr6_-_135498417 2.12 ENST00000681022.1
ENST00000680033.1
AHI1
Abelson helper integration site 1
chr6_-_44313306 2.12 ENST00000244571.5
AARS2
alanyl-tRNA synthetase 2, mitochondrial
chr12_+_8989612 2.07 ENST00000266551.8
KLRG1
killer cell lectin like receptor G1
chr1_-_6602859 2.04 ENST00000377658.8
KLHL21
kelch like family member 21
chr1_-_6602885 2.00 ENST00000377663.3
KLHL21
kelch like family member 21
chr5_-_139198284 1.95 ENST00000507002.5
ENST00000505830.5
ENST00000508639.5
ENST00000265195.9
SIL1
SIL1 nucleotide exchange factor
chr14_-_23119248 1.90 ENST00000206513.6
CEBPE
CCAAT enhancer binding protein epsilon
chr3_+_11137093 1.88 ENST00000438284.2
HRH1
histamine receptor H1
chr5_-_139198358 1.83 ENST00000394817.7
SIL1
SIL1 nucleotide exchange factor
chrX_+_78945332 1.77 ENST00000544091.1
ENST00000171757.3
P2RY10
P2Y receptor family member 10
chr8_-_17895403 1.76 ENST00000381840.5
ENST00000398054.5
FGL1
fibrinogen like 1
chr18_+_44700796 1.73 ENST00000677130.1
SETBP1
SET binding protein 1
chr3_-_52679713 1.70 ENST00000296302.11
ENST00000356770.8
ENST00000337303.8
ENST00000409057.5
ENST00000410007.5
ENST00000409114.7
ENST00000409767.5
ENST00000423351.5
PBRM1
polybromo 1
chr19_-_45782388 1.68 ENST00000458663.6
DMPK
DM1 protein kinase
chr4_-_99435134 1.56 ENST00000476959.5
ENST00000482593.5
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr10_+_18260715 1.53 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr3_-_151278535 1.47 ENST00000309170.8
P2RY14
purinergic receptor P2Y14
chr17_+_42900791 1.44 ENST00000592383.5
ENST00000253801.7
ENST00000585489.1
G6PC1
glucose-6-phosphatase catalytic subunit 1
chr12_-_102197827 1.43 ENST00000329406.5
PMCH
pro-melanin concentrating hormone
chr8_-_17895487 1.43 ENST00000427924.5
ENST00000381841.4
FGL1
fibrinogen like 1
chr11_-_14891643 1.37 ENST00000532378.5
CYP2R1
cytochrome P450 family 2 subfamily R member 1
chr16_+_2033264 1.37 ENST00000565855.5
ENST00000566198.1
SLC9A3R2
SLC9A3 regulator 2
chr12_-_70788914 1.32 ENST00000342084.8
PTPRR
protein tyrosine phosphatase receptor type R
chr11_-_82997477 1.30 ENST00000534301.5
RAB30
RAB30, member RAS oncogene family
chr22_-_39319595 1.20 ENST00000427905.5
ENST00000216146.9
ENST00000402527.5
RPL3
ribosomal protein L3
chr2_-_151973991 1.17 ENST00000534999.6
ENST00000637217.1
ENST00000360283.11
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr1_+_196943738 1.13 ENST00000367415.8
ENST00000367421.5
ENST00000649283.1
ENST00000476712.6
ENST00000496448.6
ENST00000473386.1
ENST00000649960.1
CFHR2
complement factor H related 2
chr13_-_113410938 0.94 ENST00000682618.1
ADPRHL1
ADP-ribosylhydrolase like 1
chr5_-_136365476 0.88 ENST00000378459.7
ENST00000502753.4
ENST00000513104.6
ENST00000352189.8
TRPC7
transient receptor potential cation channel subfamily C member 7
chr5_-_16508990 0.86 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chr11_-_82997394 0.85 ENST00000525117.5
ENST00000532548.5
RAB30
RAB30, member RAS oncogene family
chr5_-_16508858 0.76 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr9_-_114078293 0.73 ENST00000265132.8
AMBP
alpha-1-microglobulin/bikunin precursor
chr19_-_11339573 0.73 ENST00000222120.8
RAB3D
RAB3D, member RAS oncogene family
chr11_+_60088657 0.65 ENST00000617306.1
ENST00000278888.8
MS4A2
membrane spanning 4-domains A2
chr4_-_122621011 0.63 ENST00000611104.2
ENST00000648588.1
IL21
interleukin 21
chr5_-_16508812 0.60 ENST00000683414.1
RETREG1
reticulophagy regulator 1
chr3_-_87276577 0.60 ENST00000344265.8
ENST00000350375.7
POU1F1
POU class 1 homeobox 1
chr5_-_16508951 0.59 ENST00000682628.1
RETREG1
reticulophagy regulator 1
chr5_+_42548043 0.56 ENST00000618088.4
ENST00000612382.4
GHR
growth hormone receptor
chr17_-_47821760 0.56 ENST00000613735.4
ENST00000007414.8
ENST00000392507.7
OSBPL7
oxysterol binding protein like 7
chr18_+_58196736 0.43 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr11_+_7597182 0.41 ENST00000528883.5
PPFIBP2
PPFIA binding protein 2
chr5_-_16508788 0.40 ENST00000682142.1
RETREG1
reticulophagy regulator 1
chr14_+_94026314 0.31 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr14_+_73058591 0.31 ENST00000525161.5
RBM25
RNA binding motif protein 25
chr10_-_14954018 0.31 ENST00000378241.5
ENST00000456122.1
ENST00000418843.5
ENST00000378249.5
ENST00000396817.6
ENST00000378255.5
ENST00000378254.5
ENST00000357717.6
ENST00000378258.5
ENST00000378246.6
ENST00000378278.7
DCLRE1C
DNA cross-link repair 1C
chr17_-_61591192 0.29 ENST00000521764.3
NACA2
nascent polypeptide associated complex subunit alpha 2
chr10_+_84452208 0.27 ENST00000480006.1
CCSER2
coiled-coil serine rich protein 2
chr21_-_42366525 0.25 ENST00000291527.3
TFF1
trefoil factor 1
chr3_+_30606574 0.23 ENST00000295754.10
ENST00000359013.4
TGFBR2
transforming growth factor beta receptor 2
chr1_-_117210918 0.22 ENST00000369458.8
ENST00000430871.3
ENST00000328189.7
VTCN1
V-set domain containing T cell activation inhibitor 1
chr18_+_34710249 0.18 ENST00000680346.1
ENST00000348997.9
ENST00000681274.1
ENST00000680822.1
ENST00000680767.2
ENST00000597599.5
ENST00000444659.6
DTNA
dystrobrevin alpha
chr3_-_11720690 0.11 ENST00000426568.5
VGLL4
vestigial like family member 4
chr16_+_30664334 0.10 ENST00000287468.5
FBRS
fibrosin
chr1_-_205775449 0.05 ENST00000235932.8
ENST00000437324.6
ENST00000414729.1
ENST00000367139.8
RAB29
RAB29, member RAS oncogene family
chr1_+_40738834 0.05 ENST00000525290.5
ENST00000530965.5
ENST00000416859.6
ENST00000308733.9
NFYC
nuclear transcription factor Y subunit gamma

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 38.3 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
6.3 18.9 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
2.9 8.6 GO:1902905 positive regulation of fibril organization(GO:1902905)
2.8 41.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
2.3 6.9 GO:0034769 basement membrane disassembly(GO:0034769)
1.9 9.3 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
1.8 12.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
1.7 6.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
1.6 4.9 GO:0060398 mineralocorticoid receptor signaling pathway(GO:0031959) regulation of growth hormone receptor signaling pathway(GO:0060398) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
1.6 6.4 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.4 10.0 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
1.4 15.4 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
1.3 7.7 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
1.3 5.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
1.2 9.3 GO:0071726 toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
1.2 23.1 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.1 8.6 GO:2000467 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.9 16.9 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.8 8.5 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.8 7.4 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.7 3.0 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.7 5.7 GO:0051414 response to cortisol(GO:0051414)
0.7 2.1 GO:0039022 pronephric nephron morphogenesis(GO:0039007) pronephric nephron tubule morphogenesis(GO:0039008) pronephric duct development(GO:0039022) pronephric duct morphogenesis(GO:0039023) Kupffer's vesicle development(GO:0070121)
0.7 5.5 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.7 3.3 GO:1902847 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.6 2.9 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670)
0.5 5.3 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.5 2.5 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.5 6.5 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.5 6.6 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.5 7.0 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
0.4 3.0 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.4 2.5 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.4 3.2 GO:0061709 reticulophagy(GO:0061709)
0.4 3.6 GO:0015886 heme transport(GO:0015886)
0.4 12.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.3 1.4 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.3 2.6 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.3 2.9 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 2.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.3 2.0 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.3 11.7 GO:0050832 defense response to fungus(GO:0050832)
0.3 2.2 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.3 1.3 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.3 2.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 3.6 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2 4.1 GO:0006020 inositol metabolic process(GO:0006020)
0.2 3.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 1.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 17.7 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.2 8.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 0.9 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.2 0.7 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 3.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 14.4 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.2 2.2 GO:0070307 lens fiber cell development(GO:0070307)
0.2 1.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.2 1.7 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1 8.2 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 0.2 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.1 7.7 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.1 6.9 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 4.0 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 0.6 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 11.4 GO:0051225 spindle assembly(GO:0051225)
0.1 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 3.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 0.9 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.7 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 4.3 GO:0006968 cellular defense response(GO:0006968)
0.0 2.6 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 1.9 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.6 GO:0071397 cellular response to cholesterol(GO:0071397)
0.0 0.3 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 2.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 1.2 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 4.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 9.4 GO:0009615 response to virus(GO:0009615)
0.0 1.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 38.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
2.6 15.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
1.7 5.1 GO:0035517 PR-DUB complex(GO:0035517)
1.3 11.4 GO:0070652 HAUS complex(GO:0070652)
1.0 6.9 GO:0036021 endolysosome lumen(GO:0036021)
0.9 18.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.9 37.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.9 12.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.8 9.3 GO:0060171 stereocilium membrane(GO:0060171)
0.7 8.6 GO:0097413 Lewy body(GO:0097413)
0.5 3.6 GO:1990635 proximal dendrite(GO:1990635)
0.5 4.0 GO:0005827 polar microtubule(GO:0005827)
0.5 6.0 GO:0031209 SCAR complex(GO:0031209)
0.3 9.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 14.4 GO:0008305 integrin complex(GO:0008305)
0.3 3.2 GO:0005577 fibrinogen complex(GO:0005577)
0.3 10.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 18.6 GO:0015030 Cajal body(GO:0015030)
0.2 3.3 GO:0097418 neurofibrillary tangle(GO:0097418)
0.2 7.7 GO:0042629 mast cell granule(GO:0042629)
0.2 0.6 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 16.9 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 2.1 GO:0036038 MKS complex(GO:0036038)
0.1 13.1 GO:0005643 nuclear pore(GO:0005643)
0.1 4.9 GO:0031904 endosome lumen(GO:0031904)
0.1 7.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 6.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 8.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 2.5 GO:0000178 exosome (RNase complex)(GO:0000178)
0.1 5.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 1.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 3.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 11.7 GO:0034774 secretory granule lumen(GO:0034774)
0.1 6.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 12.0 GO:0001726 ruffle(GO:0001726)
0.0 14.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.3 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 3.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.7 GO:0090544 BAF-type complex(GO:0090544)
0.0 2.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.9 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 5.9 GO:0043209 myelin sheath(GO:0043209)
0.0 2.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 38.3 GO:0016019 peptidoglycan receptor activity(GO:0016019)
6.3 18.9 GO:0008859 exoribonuclease II activity(GO:0008859)
1.8 7.4 GO:0019976 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
1.6 6.4 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
1.5 7.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.2 9.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.0 15.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.9 2.6 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.8 4.9 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.7 6.6 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.6 3.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.6 6.5 GO:0004875 complement receptor activity(GO:0004875)
0.6 8.5 GO:0019957 C-C chemokine binding(GO:0019957)
0.6 11.7 GO:0050786 RAGE receptor binding(GO:0050786)
0.5 18.0 GO:0042605 peptide antigen binding(GO:0042605)
0.5 1.4 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.5 12.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 3.6 GO:0015232 heme transporter activity(GO:0015232)
0.4 15.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.4 5.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.4 12.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.4 5.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 2.9 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 9.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 6.9 GO:0001968 fibronectin binding(GO:0001968)
0.2 1.5 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.2 2.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 0.9 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.2 1.9 GO:0004969 histamine receptor activity(GO:0004969)
0.2 2.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 2.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 5.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.2 0.6 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.2 2.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 4.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 0.7 GO:0019862 IgA binding(GO:0019862)
0.1 3.6 GO:0070402 NADPH binding(GO:0070402)
0.1 3.3 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.8 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 40.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 6.6 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 1.2 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.1 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 5.3 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.7 GO:0019863 IgE binding(GO:0019863)
0.1 0.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 6.0 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 2.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 25.3 GO:0003924 GTPase activity(GO:0003924)
0.0 1.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 3.1 GO:0005518 collagen binding(GO:0005518)
0.0 3.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 2.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 7.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 7.9 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 1.7 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 13.0 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 3.5 GO:0003682 chromatin binding(GO:0003682)
0.0 15.9 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 38.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 4.9 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.3 7.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.3 14.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.2 12.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 27.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 12.7 PID PI3KCI PATHWAY Class I PI3K signaling events
0.2 6.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 5.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 8.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.0 PID IL1 PATHWAY IL1-mediated signaling events
0.1 4.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 6.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 4.4 PID BCR 5PATHWAY BCR signaling pathway
0.1 2.5 PID TNF PATHWAY TNF receptor signaling pathway
0.1 3.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.4 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 2.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 4.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 7.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.4 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 6.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 5.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 38.3 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
1.4 8.5 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.9 18.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.6 6.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.6 6.9 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.6 8.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.5 4.9 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.5 11.7 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.4 42.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 8.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 3.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.3 7.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.3 12.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 27.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.3 6.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 24.4 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.2 3.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 2.1 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 4.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 9.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 0.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 11.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 2.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 12.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 7.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling