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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for KLF7

Z-value: 1.70

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.15 KLF7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg38_v1_chr2_-_207165923_207165965,
hg38_v1_chr2_-_207167220_207167267		0.391.6e-09Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_103376887 8.79 ENST00000372634.1
BEX3
brain expressed X-linked 3
chrX_+_103376389 8.04 ENST00000372645.3
ENST00000372635.1
BEX3
brain expressed X-linked 3
chrX_+_103376488 7.93 ENST00000361298.9
BEX3
brain expressed X-linked 3
chr1_-_157138474 6.03 ENST00000326786.4
ETV3
ETS variant transcription factor 3
chr8_+_11284789 5.78 ENST00000221086.8
MTMR9
myotubularin related protein 9
chr19_-_38899800 5.75 ENST00000414941.5
ENST00000358931.9
ENST00000392081.6
SIRT2
sirtuin 2
chrX_-_93673558 5.71 ENST00000475430.2
ENST00000373079.4
NAP1L3
nucleosome assembly protein 1 like 3
chr15_+_74130243 5.30 ENST00000561740.5
ENST00000435464.5
ISLR2
immunoglobulin superfamily containing leucine rich repeat 2
chr4_+_155758990 4.88 ENST00000505154.5
ENST00000652626.1
ENST00000502959.5
ENST00000264424.13
ENST00000505764.5
ENST00000507146.5
ENST00000503520.5
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
chr19_-_38899529 4.88 ENST00000249396.12
ENST00000437828.5
SIRT2
sirtuin 2
chr17_+_18315273 4.07 ENST00000406438.5
SMCR8
SMCR8-C9orf72 complex subunit
chr14_-_100568070 3.57 ENST00000557378.6
ENST00000443071.6
ENST00000637646.1
BEGAIN
brain enriched guanylate kinase associated
chr4_+_155759365 3.50 ENST00000513437.1
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
chr1_-_18902520 3.26 ENST00000538839.5
ENST00000290597.9
ENST00000375341.8
ALDH4A1
aldehyde dehydrogenase 4 family member A1
chr17_-_18314956 2.34 ENST00000321105.10
ENST00000542570.5
TOP3A
DNA topoisomerase III alpha
chr6_-_33271835 2.16 ENST00000482399.5
ENST00000445902.3
VPS52
VPS52 subunit of GARP complex
chr17_-_19377876 2.04 ENST00000674596.1
ENST00000642870.2
B9D1
B9 domain containing 1
chr1_-_157138388 1.93 ENST00000368192.9
ETV3
ETS variant transcription factor 3
chr3_-_105869035 1.77 ENST00000447441.6
ENST00000403724.5
ENST00000405772.5
CBLB
Cbl proto-oncogene B
chr19_-_45792755 1.60 ENST00000377735.7
ENST00000270223.7
DMWD
DM1 locus, WD repeat containing
chr12_+_53380141 1.49 ENST00000551969.5
ENST00000327443.9
SP1
Sp1 transcription factor
chr7_+_49773632 1.35 ENST00000340652.5
VWC2
von Willebrand factor C domain containing 2
chr2_-_187565751 1.31 ENST00000421427.5
TFPI
tissue factor pathway inhibitor
chr1_-_161132577 1.20 ENST00000464113.1
DEDD
death effector domain containing
chr1_-_161132659 1.15 ENST00000368006.8
ENST00000490843.6
ENST00000545495.5
DEDD
death effector domain containing
chr17_+_19378476 1.14 ENST00000395604.8
ENST00000482850.1
MAPK7
mitogen-activated protein kinase 7
chr12_-_49189053 1.12 ENST00000550767.6
ENST00000546918.1
ENST00000679733.1
ENST00000552924.2
ENST00000301071.12
TUBA1A
tubulin alpha 1a
chr13_-_32538819 1.02 ENST00000674452.1
ENST00000674422.1
ENST00000674349.1
ENST00000674465.1
ENST00000674327.1
ENST00000505213.5
ENST00000357505.10
ENST00000399396.7
N4BP2L2
NEDD4 binding protein 2 like 2
chr17_+_40219325 0.98 ENST00000585043.5
ENST00000394103.7
WIPF2
WAS/WASL interacting protein family member 2
chr19_+_38899946 0.96 ENST00000572515.5
ENST00000313582.6
ENST00000575359.5
NFKBIB
NFKB inhibitor beta
chr17_+_43398984 0.84 ENST00000320033.5
ARL4D
ADP ribosylation factor like GTPase 4D
chr15_+_92393841 0.72 ENST00000268164.8
ENST00000539113.5
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr6_-_30617232 0.68 ENST00000376511.7
PPP1R10
protein phosphatase 1 regulatory subunit 10
chr2_-_74482914 0.66 ENST00000290418.4
ENST00000393965.8
CCDC142
coiled-coil domain containing 142
chr1_+_201283452 0.64 ENST00000263946.7
ENST00000367324.8
PKP1
plakophilin 1
chr3_-_105868964 0.64 ENST00000394030.8
CBLB
Cbl proto-oncogene B
chr12_+_49961864 0.61 ENST00000293599.7
AQP5
aquaporin 5
chr21_+_31873010 0.58 ENST00000270112.7
HUNK
hormonally up-regulated Neu-associated kinase
chr3_-_126083922 0.54 ENST00000514891.5
ENST00000512470.5
ENST00000504035.5
ENST00000513723.5
ENST00000510651.5
ENST00000514333.5
ENST00000360370.9
ENST00000514677.5
SLC41A3
solute carrier family 41 member 3
chr17_-_42824248 0.54 ENST00000593205.5
ENST00000361523.8
ENST00000590099.6
ENST00000438274.7
BECN1
beclin 1
chr17_-_82098223 0.51 ENST00000306749.4
ENST00000635197.1
FASN
fatty acid synthase
chr5_+_177133005 0.48 ENST00000510954.5
ENST00000354179.8
NSD1
nuclear receptor binding SET domain protein 1
chr5_+_141968886 0.43 ENST00000347642.7
RNF14
ring finger protein 14
chr12_-_49188811 0.05 ENST00000295766.9
TUBA1A
tubulin alpha 1a
chr12_-_46372763 0.04 ENST00000256689.10
SLC38A2
solute carrier family 38 member 2
chr6_+_37257762 0.00 ENST00000373491.3
TBC1D22B
TBC1 domain family member 22B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 GO:2000777 positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
1.1 3.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.7 8.0 GO:0097012 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.6 4.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.5 1.5 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.3 1.1 GO:0030821 negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821)
0.2 27.1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.2 0.5 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.2 2.3 GO:0006265 DNA topological change(GO:0006265)
0.2 2.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2 2.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 0.6 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 1.3 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 1.0 GO:1902037 positive regulation of hematopoietic stem cell proliferation(GO:1902035) negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.1 0.6 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 0.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 5.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 0.5 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 5.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.4 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 2.0 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 4.9 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
1.2 10.6 GO:0072687 meiotic spindle(GO:0072687)
0.7 4.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.3 2.2 GO:1990745 EARP complex(GO:1990745)
0.2 0.5 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.0 GO:0036038 MKS complex(GO:0036038)
0.1 0.7 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 3.5 GO:0016605 PML body(GO:0016605)
0.0 2.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 24.8 GO:0005163 nerve growth factor receptor binding(GO:0005163)
3.5 10.6 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.8 2.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.5 8.0 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.3 5.8 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 2.0 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 3.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 4.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.2 GO:0016295 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.1 0.5 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 0.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 1.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.5 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 2.2 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 10.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.3 PID ATM PATHWAY ATM pathway
0.0 2.4 PID CD40 PATHWAY CD40/CD40L signaling
0.0 5.2 PID P73PATHWAY p73 transcription factor network
0.0 1.1 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.8 ST GAQ PATHWAY G alpha q Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 2.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.3 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 1.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.8 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 3.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives