Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for KLF8
Z-value: 12.82
Motif logo
Transcription factors associated with KLF8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF8 | hg38_v1_chrX_+_56232343_56232363 | 0.66 | 1.5e-28 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_105771405 Show fit | 42.74 |
ENST00000641136.1
ENST00000390551.6 |
immunoglobulin heavy constant gamma 3 (G3m marker) |
|
| chr6_+_33080445 Show fit | 31.01 |
ENST00000428835.5
|
major histocompatibility complex, class II, DP beta 1 |
|
| chr16_+_176659 Show fit | 28.15 |
ENST00000320868.9
ENST00000397797.1 |
hemoglobin subunit alpha 1 |
|
| chr15_+_68930488 Show fit | 26.35 |
ENST00000310673.4
ENST00000448182.7 ENST00000260364.9 |
sperm equatorial segment protein 1 NADPH oxidase 5 |
|
| chr6_-_33080710 Show fit | 25.42 |
ENST00000419277.5
|
major histocompatibility complex, class II, DP alpha 1 |
|
| chr22_-_39152622 Show fit | 23.39 |
ENST00000216133.10
|
chromobox 7 |
|
| chr8_-_27611325 Show fit | 23.38 |
ENST00000523500.5
|
clusterin |
|
| chr16_+_172869 Show fit | 22.52 |
ENST00000251595.11
ENST00000397806.1 ENST00000484216.1 |
hemoglobin subunit alpha 2 |
|
| chr6_+_31897775 Show fit | 21.68 |
ENST00000469372.5
ENST00000497706.5 |
complement C2 |
|
| chr15_+_68930570 Show fit | 21.58 |
ENST00000455873.7
|
NADPH oxidase 5 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 242.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.5 | 128.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 13.5 | 67.3 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.9 | 64.2 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 1.3 | 54.8 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.8 | 51.3 | GO:0006968 | cellular defense response(GO:0006968) |
| 16.0 | 47.9 | GO:0043012 | regulation of fusion of sperm to egg plasma membrane(GO:0043012) |
| 2.2 | 42.0 | GO:0015671 | oxygen transport(GO:0015671) |
| 5.6 | 39.0 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.7 | 38.9 | GO:0015701 | bicarbonate transport(GO:0015701) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 550.5 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 4.2 | 208.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 5.5 | 105.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 5.5 | 81.8 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.1 | 75.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 62.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 61.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 61.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 60.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 1.2 | 47.7 | GO:0005859 | muscle myosin complex(GO:0005859) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 226.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 146.4 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.0 | 138.4 | GO:0003823 | antigen binding(GO:0003823) |
| 2.6 | 102.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.5 | 100.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.9 | 67.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.6 | 59.7 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 53.6 | GO:0099600 | transmembrane receptor activity(GO:0099600) |
| 0.8 | 52.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 7.0 | 49.3 | GO:0015252 | hydrogen ion channel activity(GO:0015252) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 98.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.8 | 79.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 71.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 61.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.7 | 54.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 1.1 | 53.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.0 | 49.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 42.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 37.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 37.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 272.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 133.1 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 1.1 | 105.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 4.8 | 99.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.1 | 54.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 2.8 | 52.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 1.5 | 41.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.6 | 40.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 39.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.0 | 39.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |