Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for LHX3

Z-value: 0.82

Motif logo

logo of

Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
LHX3
ENSG00000107187.17 LHX3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg38_v1_chr9_-_136203183_136203194,
hg38_v1_chr9_-_136205122_136205133		-0.366.3e-08Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_26103922 6.73 ENST00000377803.4
H4C3
H4 clustered histone 3
chr14_+_34993240 6.10 ENST00000677647.1
SRP54
signal recognition particle 54
chr1_-_150235972 5.58 ENST00000534220.1
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr6_+_106360668 5.29 ENST00000633556.3
CRYBG1
crystallin beta-gamma domain containing 1
chr1_-_23799533 5.03 ENST00000429356.5
GALE
UDP-galactose-4-epimerase
chr3_-_64019334 4.35 ENST00000480205.5
PSMD6
proteasome 26S subunit, non-ATPase 6
chr13_+_30422487 4.33 ENST00000638137.1
ENST00000635918.2
UBE2L5
ubiquitin conjugating enzyme E2 L5
chr1_-_150236064 4.12 ENST00000532744.2
ENST00000369114.9
ENST00000369115.3
ENST00000583931.6
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr1_-_150235995 4.07 ENST00000436748.6
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr1_-_150235943 3.54 ENST00000533654.5
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr3_-_142029108 3.43 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr4_+_112647059 3.20 ENST00000511529.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr7_-_36724457 3.17 ENST00000617537.5
ENST00000435386.1
AOAH
acyloxyacyl hydrolase
chr12_-_118190510 3.11 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr16_-_28623560 3.07 ENST00000350842.8
SULT1A1
sulfotransferase family 1A member 1
chrX_+_108045050 3.07 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chrX_+_108044967 3.03 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr16_+_67570741 2.99 ENST00000644753.1
ENST00000642819.1
ENST00000645306.1
CTCF
CCCTC-binding factor
chr7_-_36724543 2.98 ENST00000612871.4
AOAH
acyloxyacyl hydrolase
chr9_+_69145463 2.89 ENST00000636438.1
TJP2
tight junction protein 2
chr15_+_64387828 2.48 ENST00000261884.8
TRIP4
thyroid hormone receptor interactor 4
chr14_+_61697622 2.43 ENST00000539097.2
HIF1A
hypoxia inducible factor 1 subunit alpha
chr12_-_10130241 2.39 ENST00000353231.9
ENST00000525605.1
CLEC7A
C-type lectin domain containing 7A
chr15_+_65550819 2.38 ENST00000569894.5
HACD3
3-hydroxyacyl-CoA dehydratase 3
chr12_-_7503841 2.35 ENST00000359156.8
CD163
CD163 molecule
chr9_-_125484490 2.31 ENST00000444226.1
MAPKAP1
MAPK associated protein 1
chr17_-_40937641 2.24 ENST00000209718.8
KRT23
keratin 23
chr12_-_10130143 2.21 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
CLEC7A
C-type lectin domain containing 7A
chr18_+_58341038 2.18 ENST00000679791.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr1_-_45522870 2.13 ENST00000424390.2
PRDX1
peroxiredoxin 1
chrX_-_13817027 2.11 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
GPM6B
glycoprotein M6B
chr17_-_40937445 1.99 ENST00000436344.7
ENST00000485751.1
KRT23
keratin 23
chr11_-_63608542 1.95 ENST00000540943.1
PLAAT3
phospholipase A and acyltransferase 3
chr10_+_92591733 1.95 ENST00000676647.1
KIF11
kinesin family member 11
chr12_-_7503744 1.94 ENST00000396620.7
ENST00000432237.3
CD163
CD163 molecule
chr16_+_15395745 1.86 ENST00000287594.7
ENST00000396385.4
ENST00000568766.1
MPV17L
ENSG00000261130.5
MPV17 mitochondrial inner membrane protein like
novel protein
chr4_+_41935114 1.83 ENST00000508448.5
ENST00000513702.5
ENST00000325094.9
TMEM33
transmembrane protein 33
chr19_+_49513353 1.68 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr1_+_207325629 1.61 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr19_+_49513154 1.58 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
FCGRT
Fc fragment of IgG receptor and transporter
chr17_+_37491464 1.53 ENST00000613659.1
DUSP14
dual specificity phosphatase 14
chr3_+_138621225 1.48 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr3_-_47475811 1.46 ENST00000265565.10
ENST00000428413.5
SCAP
SREBF chaperone
chr9_+_122370523 1.44 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr5_+_68290637 1.39 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr14_+_39114289 1.32 ENST00000396249.7
ENST00000250379.13
ENST00000534684.7
ENST00000308317.12
ENST00000527381.2
GEMIN2
gem nuclear organelle associated protein 2
chr2_-_98663464 1.29 ENST00000414521.6
MGAT4A
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
chr7_+_92057602 1.24 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9
chr3_+_158110052 1.15 ENST00000295930.7
ENST00000471994.5
ENST00000482822.3
ENST00000476899.6
ENST00000683899.1
ENST00000684604.1
ENST00000682164.1
ENST00000464171.5
ENST00000611884.5
ENST00000312179.10
ENST00000475278.6
RSRC1
arginine and serine rich coiled-coil 1
chr3_+_141387801 1.14 ENST00000514251.5
ZBTB38
zinc finger and BTB domain containing 38
chr9_+_122371036 1.13 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr3_+_138621207 1.12 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr3_+_69763726 1.06 ENST00000448226.9
MITF
melanocyte inducing transcription factor
chr9_-_72953047 1.05 ENST00000297785.8
ENST00000376939.5
ALDH1A1
aldehyde dehydrogenase 1 family member A1
chrX_-_107000185 1.02 ENST00000355610.9
MORC4
MORC family CW-type zinc finger 4
chr1_-_158426237 0.94 ENST00000641042.1
OR10K2
olfactory receptor family 10 subfamily K member 2
chr3_+_63967738 0.94 ENST00000484332.1
ATXN7
ataxin 7
chr5_-_88823763 0.85 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
MEF2C
myocyte enhancer factor 2C
chr8_-_18083278 0.84 ENST00000636691.1
ASAH1
N-acylsphingosine amidohydrolase 1
chr6_+_82363199 0.83 ENST00000535040.4
TPBG
trophoblast glycoprotein
chr4_+_41613476 0.81 ENST00000508466.1
LIMCH1
LIM and calponin homology domains 1
chr9_+_122371014 0.78 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr3_+_41194741 0.69 ENST00000643541.1
ENST00000426215.5
ENST00000645210.1
ENST00000646381.1
ENST00000405570.6
ENST00000642248.1
ENST00000433400.6
CTNNB1
catenin beta 1
chr17_-_44066595 0.67 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr7_+_107583919 0.63 ENST00000491150.5
BCAP29
B cell receptor associated protein 29
chr11_+_60056587 0.62 ENST00000395032.6
ENST00000358152.6
MS4A3
membrane spanning 4-domains A3
chr18_-_24311495 0.61 ENST00000357041.8
OSBPL1A
oxysterol binding protein like 1A
chr18_-_24272179 0.59 ENST00000399443.7
OSBPL1A
oxysterol binding protein like 1A
chr3_-_12545499 0.54 ENST00000564146.4
MKRN2OS
MKRN2 opposite strand
chr15_-_19988117 0.53 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr12_-_42237727 0.52 ENST00000548917.1
YAF2
YY1 associated factor 2
chr8_-_79767462 0.52 ENST00000674295.1
ENST00000518733.1
ENST00000674418.1
ENST00000674358.1
ENST00000354724.8
HEY1
hes related family bHLH transcription factor with YRPW motif 1
chr1_+_244051275 0.51 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr5_-_79514127 0.50 ENST00000334082.11
HOMER1
homer scaffold protein 1
chr19_+_14583076 0.50 ENST00000547437.5
ENST00000417570.6
CLEC17A
C-type lectin domain containing 17A
chr5_-_39274515 0.50 ENST00000510188.1
FYB1
FYN binding protein 1
chr10_-_114144599 0.49 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr19_+_9185594 0.48 ENST00000344248.4
OR7D2
olfactory receptor family 7 subfamily D member 2
chr4_-_119322128 0.46 ENST00000274024.4
FABP2
fatty acid binding protein 2
chr7_+_138460238 0.46 ENST00000343526.9
TRIM24
tripartite motif containing 24
chr11_+_60056653 0.45 ENST00000278865.8
MS4A3
membrane spanning 4-domains A3
chr7_-_123199960 0.44 ENST00000194130.7
SLC13A1
solute carrier family 13 member 1
chr20_+_45416551 0.41 ENST00000639292.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chr18_+_74534493 0.38 ENST00000358821.8
CNDP1
carnosine dipeptidase 1
chr6_+_113857333 0.38 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr4_+_53377630 0.36 ENST00000337488.11
ENST00000358575.9
ENST00000507922.5
ENST00000306932.10
FIP1L1
factor interacting with PAPOLA and CPSF1
chr2_-_2324642 0.33 ENST00000650485.1
ENST00000649207.1
MYT1L
myelin transcription factor 1 like
chr3_-_165078480 0.32 ENST00000264382.8
SI
sucrase-isomaltase
chr16_-_28623330 0.31 ENST00000677940.1
ENSG00000288656.1
novel protein
chr19_-_48646155 0.31 ENST00000084798.9
CA11
carbonic anhydrase 11
chr14_+_22494810 0.30 ENST00000390493.1
TRAJ44
T cell receptor alpha joining 44
chrX_+_109535775 0.26 ENST00000218004.5
NXT2
nuclear transport factor 2 like export factor 2
chr13_-_60013178 0.25 ENST00000498416.2
ENST00000465066.5
DIAPH3
diaphanous related formin 3
chr18_+_74534594 0.22 ENST00000582365.1
CNDP1
carnosine dipeptidase 1
chr18_-_3845292 0.20 ENST00000400145.6
DLGAP1
DLG associated protein 1
chr19_+_48695952 0.20 ENST00000522966.2
ENST00000425340.3
ENST00000391876.5
FUT2
fucosyltransferase 2
chr1_+_115029823 0.19 ENST00000256592.3
TSHB
thyroid stimulating hormone subunit beta
chr1_+_197268204 0.19 ENST00000535699.5
ENST00000538660.5
CRB1
crumbs cell polarity complex component 1
chr4_+_157220691 0.17 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr5_-_16916400 0.14 ENST00000513882.5
MYO10
myosin X
chr13_-_49401497 0.08 ENST00000457041.5
ENST00000355854.8
CAB39L
calcium binding protein 39 like
chrX_+_85003863 0.08 ENST00000373173.7
APOOL
apolipoprotein O like
chr4_-_23890035 0.07 ENST00000507380.1
ENST00000264867.7
PPARGC1A
PPARG coactivator 1 alpha
chr19_+_48445961 0.05 ENST00000253237.10
GRWD1
glutamate rich WD repeat containing 1
chr12_-_86256299 0.04 ENST00000552808.6
ENST00000547225.5
MGAT4C
MGAT4 family member C
chr7_+_120273129 0.02 ENST00000331113.9
KCND2
potassium voltage-gated channel subfamily D member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
1.1 3.3 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.6 1.9 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.6 3.0 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.5 2.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.5 1.8 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.4 2.4 GO:0070101 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.4 5.0 GO:0019388 galactose catabolic process(GO:0019388)
0.4 2.9 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.3 2.4 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.3 17.3 GO:0043486 histone exchange(GO:0043486)
0.3 6.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.3 1.6 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.2 1.5 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.2 4.6 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.2 2.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 1.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.2 2.1 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 0.5 GO:0036304 umbilical cord morphogenesis(GO:0036304) umbilical cord development(GO:0061027)
0.2 3.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.7 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
0.1 3.1 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.5 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 3.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.8 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 1.9 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 1.2 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 0.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.4 GO:1900103 NFAT protein import into nucleus(GO:0051531) positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.1 2.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 4.3 GO:0006953 acute-phase response(GO:0006953)
0.1 0.4 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.1 2.9 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.4 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 2.5 GO:1901998 toxin transport(GO:1901998)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 4.4 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 1.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.0 0.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 1.3 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.2 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 1.1 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 3.0 GO:0070268 cornification(GO:0070268)
0.0 0.2 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.2 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.5 GO:0019433 triglyceride catabolic process(GO:0019433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 17.3 GO:0000812 Swr1 complex(GO:0000812)
0.7 6.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.3 1.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.3 1.2 GO:0044307 dendritic branch(GO:0044307)
0.2 1.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 4.4 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 0.7 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 2.3 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 2.4 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 3.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 3.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.4 GO:0043073 germ cell nucleus(GO:0043073)
0.0 2.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 4.3 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 1.2 GO:0005771 multivesicular body(GO:0005771)
0.0 1.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 2.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.0 2.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.0 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 1.1 GO:0035579 specific granule membrane(GO:0035579)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
1.7 5.0 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
1.0 6.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
1.0 3.0 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.8 3.3 GO:0019770 IgG receptor activity(GO:0019770)
0.7 3.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.5 3.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.3 2.4 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.3 17.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.3 2.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.2 1.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2 0.5 GO:0042806 fucose binding(GO:0042806)
0.2 4.6 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 1.4 GO:0046935 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.5 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.7 GO:0017040 ceramidase activity(GO:0017040)
0.1 2.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.4 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 1.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 4.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 3.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 3.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 2.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 1.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.3 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.1 1.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.8 GO:0003680 AT DNA binding(GO:0003680)
0.0 2.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.7 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.2 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 3.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.5 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 0.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 3.7 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 4.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.1 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 1.6 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 5.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.9 PID E2F PATHWAY E2F transcription factor network
0.0 0.7 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 3.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 3.7 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 1.9 REACTOME KINESINS Genes involved in Kinesins
0.1 2.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 4.4 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 1.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 3.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 6.1 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.9 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 1.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation