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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MAFA

Z-value: 2.81

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Transcription factors associated with MAFA

Gene Symbol Gene ID Gene Info
MAFA
ENSG00000182759.4 MAFA

Activity profile of MAFA motif

Sorted Z-values of MAFA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFA

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_42313374 11.65 ENST00000598766.1
ENST00000673187.1
TMEM145
transmembrane protein 145
chr3_+_141402322 8.49 ENST00000510338.5
ENST00000504673.5
ZBTB38
zinc finger and BTB domain containing 38
chr16_-_46831134 7.78 ENST00000394806.6
ENST00000285697.9
C16orf87
chromosome 16 open reading frame 87
chr21_+_39867387 6.79 ENST00000328619.10
PCP4
Purkinje cell protein 4
chr15_+_80404320 6.03 ENST00000303329.9
ENST00000622346.4
ARNT2
aryl hydrocarbon receptor nuclear translocator 2
chr3_+_196712298 5.88 ENST00000392391.9
ENST00000296333.10
PIGX
phosphatidylinositol glycan anchor biosynthesis class X
chr2_-_25982471 5.78 ENST00000264712.8
KIF3C
kinesin family member 3C
chr11_-_777467 5.51 ENST00000397472.6
ENST00000524550.5
ENST00000319863.13
ENST00000526325.5
GATD1
glutamine amidotransferase like class 1 domain containing 1
chr1_+_163069353 5.42 ENST00000531057.5
ENST00000527809.5
ENST00000367908.8
ENST00000367909.11
RGS4
regulator of G protein signaling 4
chr3_-_196712194 4.98 ENST00000399942.4
ENST00000409690.5
CEP19
centrosomal protein 19
chrX_-_93673558 4.88 ENST00000475430.2
ENST00000373079.4
NAP1L3
nucleosome assembly protein 1 like 3
chr15_-_82647336 4.86 ENST00000617522.4
ENST00000684509.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr2_+_53971072 4.49 ENST00000422521.2
ENST00000607452.6
ACYP2
acylphosphatase 2
chr22_+_22327298 4.27 ENST00000390291.2
IGLV1-50
immunoglobulin lambda variable 1-50 (non-functional)
chr3_+_35639589 3.75 ENST00000428373.5
ARPP21
cAMP regulated phosphoprotein 21
chr6_+_32024278 3.72 ENST00000647698.1
C4B
complement C4B (Chido blood group)
chr16_+_56191476 3.63 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr2_+_118088432 3.55 ENST00000245787.9
INSIG2
insulin induced gene 2
chr2_+_190880809 3.53 ENST00000320717.8
GLS
glutaminase
chr15_-_66565959 3.25 ENST00000537670.5
LCTL
lactase like
chr4_-_18021727 3.14 ENST00000675605.1
ENST00000675927.1
ENST00000674942.1
ENST00000675143.1
ENST00000382226.5
ENST00000326877.8
ENST00000635767.1
LCORL
ligand dependent nuclear receptor corepressor like
chr9_-_127950716 3.11 ENST00000373084.8
FAM102A
family with sequence similarity 102 member A
chr8_-_131040890 2.99 ENST00000286355.10
ADCY8
adenylate cyclase 8
chr10_-_77637444 2.98 ENST00000639205.1
ENST00000639498.1
ENST00000372408.7
ENST00000372403.9
ENST00000640626.1
ENST00000404857.6
ENST00000638252.1
ENST00000640029.1
ENST00000640934.1
ENST00000639823.1
ENST00000372437.6
ENST00000639344.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr1_+_153775357 2.90 ENST00000624995.4
SLC27A3
solute carrier family 27 member 3
chr8_+_84183534 2.81 ENST00000518566.5
RALYL
RALY RNA binding protein like
chr1_-_45491150 2.80 ENST00000372086.4
TESK2
testis associated actin remodelling kinase 2
chr5_+_177426701 2.80 ENST00000507633.5
ENST00000393576.7
ENST00000355958.9
ENST00000528793.5
ENST00000512684.1
GRK6
G protein-coupled receptor kinase 6
chrX_-_47650488 2.73 ENST00000247161.7
ENST00000376983.8
ENST00000343894.8
ELK1
ETS transcription factor ELK1
chr11_+_107591222 2.68 ENST00000443271.2
ELMOD1
ELMO domain containing 1
chr1_-_216805367 2.49 ENST00000360012.7
ESRRG
estrogen related receptor gamma
chr22_-_30546682 2.49 ENST00000402034.6
SEC14L6
SEC14 like lipid binding 6
chr1_+_156154371 2.49 ENST00000368282.1
SEMA4A
semaphorin 4A
chr12_-_5945252 2.39 ENST00000546188.5
ENST00000682330.1
ANO2
anoctamin 2
chr7_-_135728177 2.36 ENST00000682651.1
ENST00000354042.8
SLC13A4
solute carrier family 13 member 4
chr12_-_5945216 2.35 ENST00000650848.1
ANO2
anoctamin 2
chr11_+_107591077 2.27 ENST00000531234.5
ENST00000265840.12
ELMOD1
ELMO domain containing 1
chr5_-_179858797 2.27 ENST00000520698.5
ENST00000518235.5
ENST00000376931.6
ENST00000518219.5
ENST00000292586.11
ENST00000521333.5
ENST00000523084.5
MRNIP
MRN complex interacting protein
chr1_+_224616302 2.22 ENST00000272133.4
CNIH3
cornichon family AMPA receptor auxiliary protein 3
chr11_+_24496988 2.21 ENST00000336930.11
LUZP2
leucine zipper protein 2
chr12_+_53423849 2.15 ENST00000257863.9
ENST00000550311.5
ENST00000379791.7
AMHR2
anti-Mullerian hormone receptor type 2
chr1_+_65992389 2.14 ENST00000423207.6
PDE4B
phosphodiesterase 4B
chr12_-_22334683 2.12 ENST00000404299.3
ENST00000396037.9
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr19_+_35269065 2.11 ENST00000595068.5
ENST00000379134.7
ENST00000594064.5
ENST00000598058.1
USF2
upstream transcription factor 2, c-fos interacting
chr16_+_28985043 2.11 ENST00000395456.7
ENST00000564277.5
ENST00000630764.2
ENST00000354453.7
LAT
linker for activation of T cells
chr15_-_89912882 2.09 ENST00000398333.7
ENST00000357484.10
ARPIN-AP3S2
ARPIN
ARPIN-AP3S2 readthrough
actin related protein 2/3 complex inhibitor
chr9_+_122371036 2.04 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr10_-_77637902 1.99 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chrX_-_66639022 1.98 ENST00000374719.8
EDA2R
ectodysplasin A2 receptor
chr19_+_12838437 1.96 ENST00000251472.9
MAST1
microtubule associated serine/threonine kinase 1
chr17_+_63477052 1.93 ENST00000290866.10
ENST00000428043.5
ACE
angiotensin I converting enzyme
chr17_+_43211835 1.88 ENST00000588693.5
ENST00000588659.5
ENST00000541594.5
ENST00000536052.5
ENST00000612339.4
TMEM106A
transmembrane protein 106A
chr12_-_132144302 1.83 ENST00000397333.4
DDX51
DEAD-box helicase 51
chr1_+_158355894 1.80 ENST00000368162.2
CD1E
CD1e molecule
chr10_-_77637789 1.77 ENST00000481070.1
ENST00000640969.1
ENST00000286628.14
ENST00000638991.1
ENST00000639913.1
ENST00000480683.2
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chrX_-_66639255 1.74 ENST00000451436.6
EDA2R
ectodysplasin A2 receptor
chr2_-_48755718 1.71 ENST00000294954.12
ENST00000403273.5
ENST00000401907.5
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr7_+_152025632 1.67 ENST00000430044.7
ENST00000431668.1
ENST00000446096.5
ENST00000423337.5
GALNT11
polypeptide N-acetylgalactosaminyltransferase 11
chr10_-_77637558 1.65 ENST00000372421.10
ENST00000639370.1
ENST00000640773.1
ENST00000638895.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr11_+_24497155 1.65 ENST00000529015.5
ENST00000533227.5
LUZP2
leucine zipper protein 2
chr10_+_119207560 1.64 ENST00000392870.3
GRK5
G protein-coupled receptor kinase 5
chr19_+_35268921 1.62 ENST00000222305.8
ENST00000343550.9
USF2
upstream transcription factor 2, c-fos interacting
chr4_+_6782674 1.60 ENST00000307659.6
ENST00000425103.5
KIAA0232
KIAA0232
chr22_-_26618026 1.60 ENST00000647684.1
CRYBB1
crystallin beta B1
chr9_+_137139139 1.58 ENST00000371561.8
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr16_+_28985251 1.55 ENST00000360872.9
ENST00000566177.5
LAT
linker for activation of T cells
chr11_-_63015804 1.53 ENST00000535878.5
ENST00000545207.5
SLC22A8
solute carrier family 22 member 8
chr14_+_80955043 1.50 ENST00000541158.6
TSHR
thyroid stimulating hormone receptor
chrX_-_43882411 1.49 ENST00000378069.5
MAOB
monoamine oxidase B
chr11_-_63015831 1.47 ENST00000430500.6
ENST00000336232.7
SLC22A8
solute carrier family 22 member 8
chr22_+_22244776 1.40 ENST00000302273.2
ENST00000403807.4
VPREB1
V-set pre-B cell surrogate light chain 1
chr19_+_35031263 1.39 ENST00000640135.1
ENST00000596348.2
SCN1B
sodium voltage-gated channel beta subunit 1
chr16_+_28638065 1.30 ENST00000683297.1
NPIPB8
nuclear pore complex interacting protein family member B8
chr7_-_135211313 1.27 ENST00000682802.1
ENST00000683848.1
ENST00000354475.5
WDR91
WD repeat domain 91
chr5_-_22853320 1.25 ENST00000504376.6
ENST00000382254.6
CDH12
cadherin 12
chr10_-_79949098 1.25 ENST00000372292.8
SFTPD
surfactant protein D
chr14_+_80955366 1.23 ENST00000342443.10
TSHR
thyroid stimulating hormone receptor
chr14_+_80955577 1.16 ENST00000642209.1
ENST00000298171.7
TSHR
thyroid stimulating hormone receptor
chr22_+_22720615 1.12 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr5_-_39270623 1.06 ENST00000512138.1
ENST00000646045.2
FYB1
FYN binding protein 1
chr17_+_27609836 1.05 ENST00000582410.5
KSR1
kinase suppressor of ras 1
chr6_+_33277117 1.04 ENST00000451237.3
B3GALT4
beta-1,3-galactosyltransferase 4
chr19_+_53538415 1.04 ENST00000648122.1
ZNF331
zinc finger protein 331
chr8_-_7056729 1.00 ENST00000330590.4
DEFA5
defensin alpha 5
chr10_-_77637633 1.00 ENST00000638223.1
ENST00000639544.1
ENST00000640807.1
ENST00000434208.6
ENST00000626620.3
ENST00000638575.1
ENST00000638759.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr20_-_59007807 0.99 ENST00000680386.1
CTSZ
cathepsin Z
chr19_+_35612729 0.97 ENST00000203166.10
HAUS5
HAUS augmin like complex subunit 5
chr14_+_80955650 0.91 ENST00000554263.5
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chr9_+_128787331 0.91 ENST00000223865.8
TBC1D13
TBC1 domain family member 13
chr10_-_77637721 0.89 ENST00000638848.1
ENST00000639406.1
ENST00000618048.2
ENST00000639120.1
ENST00000640834.1
ENST00000639601.1
ENST00000638514.1
ENST00000457953.6
ENST00000639090.1
ENST00000639489.1
ENST00000372440.6
ENST00000404771.8
ENST00000638203.1
ENST00000638306.1
ENST00000638351.1
ENST00000638606.1
ENST00000639591.1
ENST00000640182.1
ENST00000640605.1
ENST00000640141.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr19_-_48044037 0.89 ENST00000293255.3
CABP5
calcium binding protein 5
chr7_+_142598016 0.88 ENST00000620773.1
TRBV16
T cell receptor beta variable 16
chr7_-_149126306 0.87 ENST00000483014.1
ENST00000378061.7
ZNF425
zinc finger protein 425
chr22_+_22409755 0.79 ENST00000390299.2
IGLV1-40
immunoglobulin lambda variable 1-40
chr21_+_18244828 0.74 ENST00000299295.7
CHODL
chondrolectin
chr10_-_48493641 0.68 ENST00000417247.6
ARHGAP22
Rho GTPase activating protein 22
chr1_+_174799895 0.62 ENST00000489615.5
RABGAP1L
RAB GTPase activating protein 1 like
chr17_-_10421944 0.59 ENST00000403437.2
MYH8
myosin heavy chain 8
chr19_-_47231191 0.58 ENST00000439096.3
BBC3
BCL2 binding component 3
chr17_-_3433841 0.58 ENST00000248384.1
OR1E2
olfactory receptor family 1 subfamily E member 2
chr16_-_21857418 0.50 ENST00000415645.6
NPIPB4
nuclear pore complex interacting protein family member B4
chr8_-_88327475 0.44 ENST00000286614.11
MMP16
matrix metallopeptidase 16
chr17_-_78132407 0.43 ENST00000322914.7
TMC6
transmembrane channel like 6
chr11_+_118956289 0.43 ENST00000264031.3
UPK2
uroplakin 2
chr13_-_113864062 0.37 ENST00000327773.7
GAS6
growth arrest specific 6
chr7_-_22194709 0.36 ENST00000458533.5
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr9_+_122371014 0.36 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chrX_+_30241994 0.31 ENST00000378982.4
MAGEB4
MAGE family member B4
chr11_-_70662197 0.30 ENST00000409161.5
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_-_42766978 0.29 ENST00000372526.2
ENST00000236040.8
ENST00000296388.10
ENST00000397054.7
P3H1
prolyl 3-hydroxylase 1
chr21_+_43169008 0.28 ENST00000291554.6
CRYAA
crystallin alpha A
chr19_+_35666515 0.25 ENST00000617999.4
ENST00000616789.4
UPK1A
uroplakin 1A
chr15_-_40755223 0.24 ENST00000560460.5
ENST00000338376.8
ENST00000560905.1
RMDN3
regulator of microtubule dynamics 3
chr12_+_54549586 0.15 ENST00000243052.8
PDE1B
phosphodiesterase 1B
chr1_-_190477854 0.11 ENST00000367462.5
BRINP3
BMP/retinoic acid inducible neural specific 3
chr1_+_42767241 0.09 ENST00000372525.7
C1orf50
chromosome 1 open reading frame 50
chr4_-_47837949 0.08 ENST00000505909.5
ENST00000273857.9
ENST00000502252.5
CORIN
corin, serine peptidase
chr14_+_90397019 0.06 ENST00000447653.8
ENST00000356978.9
ENST00000626705.2
CALM1
calmodulin 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.9 3.7 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086)
0.8 10.3 GO:0034465 response to carbon monoxide(GO:0034465) negative regulation of cell volume(GO:0045794)
0.6 1.7 GO:0001545 primary ovarian follicle growth(GO:0001545) cellular response to luteinizing hormone stimulus(GO:0071373)
0.5 1.6 GO:0043449 olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
0.5 2.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 4.9 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.5 1.9 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.4 2.2 GO:1902612 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.3 3.7 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.3 1.7 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.3 1.2 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.3 5.9 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.3 3.7 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 2.7 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.2 3.5 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.2 2.4 GO:0008272 sulfate transport(GO:0008272)
0.2 1.4 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.2 1.5 GO:0014063 response to aluminum ion(GO:0010044) negative regulation of serotonin secretion(GO:0014063)
0.2 1.6 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 2.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 2.3 GO:2001032 positive regulation of double-strand break repair(GO:2000781) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.2 1.8 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 1.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.4 GO:2000669 oligodendrocyte apoptotic process(GO:0097252) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.1 5.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 5.8 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 3.0 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.1 3.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.1 0.3 GO:1901874 negative regulation of post-translational protein modification(GO:1901874)
0.1 2.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 3.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 3.6 GO:0043278 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.1 2.5 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 8.4 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.1 3.7 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 4.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 5.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 2.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 4.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 7.6 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 1.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 4.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.0 GO:0050832 defense response to fungus(GO:0050832)
0.0 2.8 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 0.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 1.3 GO:0034332 adherens junction organization(GO:0034332)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.9 GO:0030449 regulation of complement activation(GO:0030449)
0.0 1.1 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 1.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 9.5 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 0.3 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.6 GO:0003009 skeletal muscle contraction(GO:0003009)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 2.3 GO:0030870 Mre11 complex(GO:0030870)
0.2 3.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 4.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 5.8 GO:0097542 ciliary tip(GO:0097542)
0.1 1.6 GO:0098839 NMDA selective glutamate receptor complex(GO:0017146) postsynaptic density membrane(GO:0098839)
0.1 1.0 GO:0070652 HAUS complex(GO:0070652)
0.1 2.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 3.7 GO:0042629 mast cell granule(GO:0042629)
0.1 2.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 8.5 GO:0005901 caveola(GO:0005901)
0.1 1.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 5.0 GO:0036064 ciliary basal body(GO:0036064)
0.1 4.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.2 GO:0042599 lamellar body(GO:0042599)
0.1 12.2 GO:0072562 blood microparticle(GO:0072562)
0.1 3.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.2 GO:0005903 brush border(GO:0005903)
0.0 7.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.0 GO:0099738 cell cortex region(GO:0099738)
0.0 1.8 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 10.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
1.0 3.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.7 4.5 GO:0003998 acylphosphatase activity(GO:0003998)
0.7 4.4 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.7 2.2 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.6 3.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.6 4.8 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.6 1.7 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.5 2.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 8.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.4 6.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.4 1.9 GO:0008241 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573)
0.3 4.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.3 2.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.3 2.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.3 1.4 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.3 2.5 GO:0050682 AF-2 domain binding(GO:0050682)
0.3 4.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 3.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 1.8 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.2 5.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 1.6 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 2.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 2.5 GO:0038191 neuropilin binding(GO:0038191)
0.1 3.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.6 GO:0017018 myosin phosphatase activity(GO:0017018)
0.1 3.0 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.1 3.5 GO:0001848 complement binding(GO:0001848)
0.1 1.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.3 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1 5.8 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.0 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 1.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 3.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 2.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 10.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 1.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 7.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 2.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.4 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 6.4 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 3.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 6.5 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.2 PID ALK2 PATHWAY ALK2 signaling events
0.1 4.9 PID AURORA A PATHWAY Aurora A signaling
0.1 3.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 3.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.8 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 3.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.3 5.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 3.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 5.8 REACTOME KINESINS Genes involved in Kinesins
0.2 3.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 5.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 2.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.7 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.0 REACTOME DEFENSINS Genes involved in Defensins
0.0 1.6 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 3.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.3 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix