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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MAX_TFEB

Z-value: 9.50

Motif logo

Transcription factors associated with MAX_TFEB

Gene Symbol Gene ID Gene Info
ENSG00000125952.20 MAX
ENSG00000112561.19 TFEB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MAXhg38_v1_chr14_-_65102468_651026950.409.4e-10Click!
TFEBhg38_v1_chr6_-_41733690_41733868-0.144.6e-02Click!

Activity profile of MAX_TFEB motif

Sorted Z-values of MAX_TFEB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MAX_TFEB

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr12_-_57752265 211.60 ENST00000547281.5
ENST00000257904.11
ENST00000546489.5
ENST00000552388.1
cyclin dependent kinase 4
chr12_-_57752345 204.97 ENST00000551800.5
ENST00000549606.5
ENST00000312990.10
cyclin dependent kinase 4
chr6_-_109382397 69.03 ENST00000512821.5
CD164 molecule
chr2_-_10447771 68.16 ENST00000405333.5
ENST00000443218.1
ornithine decarboxylase 1
chr2_-_10448318 67.56 ENST00000234111.9
ornithine decarboxylase 1
chr2_+_215312028 66.40 ENST00000236959.14
ENST00000435675.5
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr4_-_99950262 64.22 ENST00000296417.6
ENST00000651623.1
H2A.Z variant histone 1
chr19_+_5681140 57.86 ENST00000579559.1
ENST00000577222.5
hydroxysteroid 11-beta dehydrogenase 1 like
ribosomal protein L36
chr20_+_45891309 54.00 ENST00000354880.9
ENST00000646241.3
ENST00000191018.9
cathepsin A
chr20_+_45891370 52.67 ENST00000607482.6
ENST00000372459.7
cathepsin A
chr19_+_10654327 50.78 ENST00000407004.7
ENST00000589998.5
ENST00000589600.5
interleukin enhancer binding factor 3
chr14_+_20455185 50.06 ENST00000555414.5
ENST00000553681.5
apurinic/apyrimidinic endodeoxyribonuclease 1
chr8_+_97644164 48.92 ENST00000336273.8
metadherin
chr3_+_158801926 45.22 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
major facilitator superfamily domain containing 1
chrX_-_101407893 44.59 ENST00000676156.1
ENST00000675592.1
ENST00000674634.2
ENST00000649178.1
ENST00000218516.4
galactosidase alpha
chr1_+_154220179 43.47 ENST00000343815.10
ubiquitin associated protein 2 like
chr1_+_43974902 43.16 ENST00000532642.5
ENST00000236067.8
ENST00000471859.6
ENST00000472174.7
ATPase H+ transporting V0 subunit b
chr1_-_183635659 42.28 ENST00000367534.5
ENST00000294742.6
actin related protein 2/3 complex subunit 5
chr6_+_159969070 42.28 ENST00000356956.6
insulin like growth factor 2 receptor
chr8_-_108443409 41.73 ENST00000678023.1
ENST00000679198.1
ENST00000678881.1
ENST00000677084.1
ENST00000676663.1
ENST00000677614.1
ENST00000677040.1
ENST00000676487.1
ENST00000677409.1
ENST00000678797.1
ENST00000678334.1
eukaryotic translation initiation factor 3 subunit E
chr3_+_127598400 41.39 ENST00000265056.12
minichromosome maintenance complex component 2
chr1_-_183635776 40.95 ENST00000359856.11
actin related protein 2/3 complex subunit 5
chr4_-_47463649 40.56 ENST00000381571.6
COMM domain containing 8
chr1_+_32651142 40.09 ENST00000414241.7
RB binding protein 4, chromatin remodeling factor
chr11_-_64246907 39.51 ENST00000309318.8
protein phosphatase 1 regulatory inhibitor subunit 14B
chr6_-_109382460 38.41 ENST00000310786.10
CD164 molecule
chr6_-_33418077 38.30 ENST00000488478.5
cutA divalent cation tolerance homolog
chr6_-_109382431 37.91 ENST00000324953.9
ENST00000275080.11
ENST00000413644.6
CD164 molecule
chr21_-_44817968 36.84 ENST00000397893.3
small ubiquitin like modifier 3
chr11_+_63938971 36.32 ENST00000539656.5
ENST00000377793.9
N-alpha-acetyltransferase 40, NatD catalytic subunit
chr14_+_20455210 35.92 ENST00000557344.5
ENST00000216714.8
ENST00000398030.8
ENST00000557181.5
ENST00000555839.5
ENST00000553368.1
ENST00000556054.5
ENST00000557054.1
ENST00000557592.5
ENST00000557150.5
apurinic/apyrimidinic endodeoxyribonuclease 1
chr19_+_8444967 35.47 ENST00000600092.5
ENST00000325495.9
ENST00000620401.4
ENST00000594907.5
ENST00000596984.5
ENST00000601645.5
heterogeneous nuclear ribonucleoprotein M
chr5_+_66144288 35.25 ENST00000334121.11
splicing regulatory glutamic acid and lysine rich protein 1
chr9_-_34048868 35.14 ENST00000379239.9
ENST00000684158.1
ENST00000379238.7
ENST00000360802.6
ubiquitin associated protein 2
chr11_+_61792878 34.14 ENST00000305885.3
ENST00000535723.1
flap structure-specific endonuclease 1
chr1_+_32651164 34.12 ENST00000373493.10
ENST00000373485.5
ENST00000458695.6
RB binding protein 4, chromatin remodeling factor
chr17_-_48610971 34.03 ENST00000239165.9
homeobox B7
chr2_-_197499857 33.70 ENST00000428204.6
ENST00000678170.1
ENST00000676933.1
ENST00000678621.1
heat shock protein family D (Hsp60) member 1
chr11_-_47642519 33.44 ENST00000302503.8
ENST00000530428.1
mitochondrial carrier 2
chr18_+_3247415 33.36 ENST00000579226.5
myosin light chain 12A
chrX_+_23667461 31.92 ENST00000379341.9
ENST00000379331.3
peroxiredoxin 4
chr5_+_110738983 31.70 ENST00000355943.8
ENST00000447245.6
solute carrier family 25 member 46
chrX_+_132023294 31.67 ENST00000481105.5
ENST00000354719.10
ENST00000394334.7
ENST00000394335.6
serine/threonine kinase 26
chr6_-_33417878 31.45 ENST00000440279.7
ENST00000607266.5
cutA divalent cation tolerance homolog
chr17_+_51260520 30.58 ENST00000225298.12
UTP18 small subunit processome component
chr1_-_50960230 30.39 ENST00000396153.7
Fas associated factor 1
chr18_+_3247778 30.33 ENST00000217652.8
ENST00000578611.5
ENST00000583449.1
myosin light chain 12A
chr17_+_51166431 29.55 ENST00000393190.4
NME/NM23 nucleoside diphosphate kinase 2
chr21_-_37073170 29.50 ENST00000399098.5
phosphatidylinositol glycan anchor biosynthesis class P
chr22_+_20117734 29.44 ENST00000416427.5
ENST00000421656.5
ENST00000423859.5
ENST00000418705.2
RAN binding protein 1
chr6_+_30721573 29.36 ENST00000330914.7
tubulin beta class I
chr21_-_44818119 28.97 ENST00000411651.6
small ubiquitin like modifier 3
chr6_-_43229451 28.54 ENST00000509253.5
ENST00000393987.2
ENST00000230431.11
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr21_-_37072688 28.46 ENST00000464265.5
ENST00000399102.5
phosphatidylinositol glycan anchor biosynthesis class P
chr21_-_37073019 28.29 ENST00000360525.9
phosphatidylinositol glycan anchor biosynthesis class P
chr14_+_35122722 27.83 ENST00000605870.5
ENST00000557404.3
protein only RNase P catalytic subunit
chr21_-_44818043 27.50 ENST00000397898.7
ENST00000332859.11
small ubiquitin like modifier 3
chr1_-_77683356 27.36 ENST00000414381.5
ENST00000370798.5
zinc finger ZZ-type containing 3
chr1_-_222712428 27.29 ENST00000355727.3
ENST00000340020.11
axin interactor, dorsalization associated
chr11_-_86068743 27.17 ENST00000356360.9
phosphatidylinositol binding clathrin assembly protein
chr12_-_56316002 26.92 ENST00000547423.5
ENST00000548360.1
ENST00000551475.5
novel protein
canopy FGF signaling regulator 2
chr1_+_42682954 26.88 ENST00000436427.1
Y-box binding protein 1
chr6_+_36594354 26.85 ENST00000373715.11
serine and arginine rich splicing factor 3
chr12_-_56315890 26.66 ENST00000551286.1
ENST00000549318.5
canopy FGF signaling regulator 2
novel protein
chr15_-_64989435 26.42 ENST00000433215.6
ENST00000558415.5
ENST00000557795.5
SPG21 abhydrolase domain containing, maspardin
chr3_-_113746218 26.28 ENST00000497255.1
ENST00000240922.8
ENST00000478020.1
ENST00000493900.5
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr2_+_112645930 26.26 ENST00000272542.8
solute carrier family 20 member 1
chr7_-_100101915 26.10 ENST00000621318.4
ENST00000343023.10
minichromosome maintenance complex component 7
chr19_-_4670331 26.00 ENST00000262947.8
ENST00000599630.1
myeloid derived growth factor
chr5_+_172983763 25.78 ENST00000519374.6
ENST00000519911.5
ATPase H+ transporting V0 subunit e1
chr10_+_69124152 25.72 ENST00000395098.5
ENST00000263559.11
VPS26, retromer complex component A
chr1_-_25906457 25.70 ENST00000426559.6
stathmin 1
chr2_-_197499826 25.55 ENST00000439605.2
ENST00000388968.8
ENST00000418022.2
heat shock protein family D (Hsp60) member 1
chr12_-_2877113 25.38 ENST00000627656.2
ENST00000359843.8
forkhead box M1
chr12_+_55716463 25.34 ENST00000551926.1
biogenesis of lysosomal organelles complex 1 subunit 1
chr2_-_197435002 25.26 ENST00000335508.11
ENST00000414963.2
ENST00000487698.5
splicing factor 3b subunit 1
chr19_+_47130782 25.14 ENST00000597808.5
ENST00000413379.7
ENST00000600706.5
ENST00000270225.12
ENST00000598840.5
ENST00000600753.1
ENST00000392776.3
SUMO1 activating enzyme subunit 1
chr12_-_2876986 25.10 ENST00000342628.6
ENST00000361953.7
forkhead box M1
chr10_+_50067888 24.82 ENST00000611324.4
ENST00000351071.11
ENST00000314664.12
ENST00000282633.10
WASH complex subunit 2A
chr1_+_32013848 24.67 ENST00000327300.12
ENST00000492989.1
KH RNA binding domain containing, signal transduction associated 1
chr17_+_7572818 24.65 ENST00000293831.13
ENST00000582169.5
ENST00000578754.5
ENST00000578495.5
ENST00000585024.5
ENST00000583802.5
ENST00000577269.5
ENST00000584784.5
ENST00000582746.5
ENST00000581621.1
eukaryotic translation initiation factor 4A1
novel transcript
chr13_+_113297217 24.63 ENST00000332556.5
lysosomal associated membrane protein 1
chr12_-_64759395 24.60 ENST00000258145.8
ENST00000543646.5
ENST00000542058.5
glucosamine (N-acetyl)-6-sulfatase
chr5_+_160421847 24.55 ENST00000352433.10
ENST00000517480.1
ENST00000520452.5
ENST00000393964.1
PTTG1 regulator of sister chromatid separation, securin
chr3_+_133574007 24.46 ENST00000503932.5
CDV3 homolog
chr2_-_43995999 24.34 ENST00000683213.1
ENST00000409946.6
leucine rich pentatricopeptide repeat containing
chr2_-_43995950 24.15 ENST00000683590.1
ENST00000683623.1
ENST00000682779.1
ENST00000682546.1
ENST00000683220.1
ENST00000683125.1
ENST00000683833.1
ENST00000683989.1
ENST00000682480.1
ENST00000260665.12
ENST00000682308.1
ENST00000682885.1
ENST00000409659.6
ENST00000447246.2
leucine rich pentatricopeptide repeat containing
chr10_+_74176537 24.08 ENST00000672394.1
adenosine kinase
chr10_-_119080794 24.07 ENST00000369144.8
ENST00000541549.2
eukaryotic translation initiation factor 3 subunit A
chr6_-_7313146 23.93 ENST00000489567.5
ENST00000479365.5
ENST00000462112.1
ENST00000397511.6
ENST00000244763.9
ENST00000474597.5
ENST00000650389.1
signal sequence receptor subunit 1
chr3_-_120093666 23.68 ENST00000316626.6
ENST00000650344.2
ENST00000678439.1
glycogen synthase kinase 3 beta
chr1_-_155262348 23.54 ENST00000302631.8
ENST00000355379.3
secretory carrier membrane protein 3
chr14_+_64503943 23.53 ENST00000556965.1
ENST00000554015.5
zinc finger and BTB domain containing 1
chr3_-_195442977 23.50 ENST00000326793.11
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr1_-_154627906 23.44 ENST00000679899.1
adenosine deaminase RNA specific
chr21_-_37072997 23.32 ENST00000430792.1
ENST00000399103.5
phosphatidylinositol glycan anchor biosynthesis class P
chr3_+_33798557 23.18 ENST00000457054.6
ENST00000413073.1
ENST00000307296.8
programmed cell death 6 interacting protein
chr5_+_172983789 23.17 ENST00000265093.4
ENST00000517669.1
ATPase H+ transporting V0 subunit e1
chr19_+_48954850 23.17 ENST00000345358.12
ENST00000539787.2
ENST00000415969.6
ENST00000354470.7
ENST00000506183.5
ENST00000391871.4
ENST00000293288.12
BCL2 associated X, apoptosis regulator
chr20_+_32819942 22.92 ENST00000375571.6
microtubule associated protein RP/EB family member 1
chrX_+_48574938 22.85 ENST00000376755.1
RNA binding motif protein 3
chr7_+_74453790 22.76 ENST00000265755.7
ENST00000424337.7
ENST00000455841.6
GTF2I repeat domain containing 1
chr3_-_113746185 22.62 ENST00000616174.1
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr12_-_56315952 22.62 ENST00000273308.9
canopy FGF signaling regulator 2
chr11_-_61792581 22.28 ENST00000537328.6
transmembrane protein 258
chr21_-_39349048 22.07 ENST00000380748.5
ENST00000380749.10
high mobility group nucleosome binding domain 1
chr15_+_45023137 21.98 ENST00000674211.1
ENST00000267814.14
sorbitol dehydrogenase
chr6_+_30721624 21.87 ENST00000396389.5
ENST00000396384.1
tubulin beta class I
chr7_+_100867379 21.85 ENST00000200457.9
ENST00000619988.4
thyroid hormone receptor interactor 6
chr15_+_43792305 21.84 ENST00000249786.9
ENST00000409960.6
ENST00000409646.5
ENST00000339624.9
ENST00000409291.5
ENST00000402131.5
ENST00000403425.5
ENST00000430901.1
small EDRK-rich factor 2
chr6_-_33418046 21.54 ENST00000494751.5
ENST00000374496.3
cutA divalent cation tolerance homolog
chr5_-_1112051 21.44 ENST00000264930.10
solute carrier family 12 member 7
chr12_+_57230336 21.38 ENST00000555773.5
ENST00000554975.5
ENST00000449049.7
serine hydroxymethyltransferase 2
chr10_-_110304894 21.36 ENST00000369603.10
survival motor neuron domain containing 1
chr6_-_33418093 21.33 ENST00000488034.6
cutA divalent cation tolerance homolog
chr1_-_77682639 21.31 ENST00000370801.8
ENST00000433749.5
zinc finger ZZ-type containing 3
chr11_+_114439424 21.24 ENST00000544196.5
ENST00000265881.10
ENST00000539754.5
ENST00000539275.5
RNA exonuclease 2
chr3_+_133573915 21.22 ENST00000431519.6
CDV3 homolog
chr19_+_12737485 21.20 ENST00000357332.8
guided entry of tail-anchored proteins factor 3, ATPase
chr1_-_38859669 21.18 ENST00000373001.4
Ras related GTP binding C
chr12_+_57230301 20.88 ENST00000553474.5
serine hydroxymethyltransferase 2
chr7_-_100101333 20.81 ENST00000303887.10
minichromosome maintenance complex component 7
chr10_-_3785197 20.76 ENST00000497571.6
Kruppel like factor 6
chr2_-_25878445 20.76 ENST00000336112.9
ENST00000435504.9
ASXL transcriptional regulator 2
chr10_+_110567666 20.73 ENST00000361804.5
structural maintenance of chromosomes 3
chr1_+_42456090 20.70 ENST00000372562.1
phosphopantothenoylcysteine synthetase
chr17_+_39200507 20.42 ENST00000678573.1
ribosomal protein L19
chr17_+_51153551 20.31 ENST00000393196.8
ENST00000336097.7
ENST00000480143.5
ENST00000511355.5
ENST00000393193.6
ENST00000376392.10
NME/NM23 nucleoside diphosphate kinase 1
NME1-NME2 readthrough
chr11_+_114439515 20.17 ENST00000539119.5
RNA exonuclease 2
chr17_+_39200334 20.16 ENST00000579260.5
ENST00000582193.5
ribosomal protein L19
chr16_+_2520339 20.11 ENST00000568263.5
ENST00000302956.8
ENST00000293971.11
ENST00000413459.7
ENST00000648227.1
ENST00000566706.5
ENST00000569879.5
amidohydrolase domain containing 2
chr17_+_32350132 20.10 ENST00000321233.10
ENST00000394673.6
ENST00000394670.9
ENST00000579634.5
ENST00000580759.5
ENST00000342555.10
ENST00000577908.5
ENST00000394679.9
ENST00000582165.1
zinc finger protein 207
chr19_+_12938598 20.05 ENST00000586760.2
ENST00000316448.10
ENST00000588454.6
calreticulin
chr4_-_2933947 19.97 ENST00000514800.5
major facilitator superfamily domain containing 10
chrX_-_101617921 19.93 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
armadillo repeat containing X-linked 6
chr2_-_97995916 19.87 ENST00000186436.10
transmembrane protein 131
chr17_+_39200275 19.76 ENST00000225430.9
ribosomal protein L19
chr17_-_78128778 19.69 ENST00000589553.5
transmembrane channel like 6
chr19_+_797392 19.67 ENST00000627714.2
ENST00000349038.8
ENST00000586481.5
polypyrimidine tract binding protein 1
chr14_-_35121950 19.61 ENST00000554361.5
ENST00000261475.10
protein phosphatase 2 regulatory subunit B''gamma
chr4_-_82373946 19.52 ENST00000352301.8
ENST00000509107.1
ENST00000353341.8
ENST00000313899.12
heterogeneous nuclear ribonucleoprotein D
chr7_+_151062547 19.37 ENST00000392826.6
ENST00000461735.1
solute carrier family 4 member 2
chr2_+_197500398 19.35 ENST00000604458.1
HSPE1-MOB4 readthrough
chr19_+_1067272 19.11 ENST00000590214.5
Rho GTPase activating protein 45
chr3_+_140941901 19.08 ENST00000453248.6
solute carrier family 25 member 36
chr6_+_137867241 19.02 ENST00000612899.5
ENST00000420009.5
TNF alpha induced protein 3
chr15_-_64989894 19.01 ENST00000416889.6
ENST00000204566.7
SPG21 abhydrolase domain containing, maspardin
chr11_-_61792783 18.89 ENST00000543510.1
transmembrane protein 258
chr19_+_41262480 18.88 ENST00000352456.7
ENST00000595018.5
ENST00000597725.5
heterogeneous nuclear ribonucleoprotein U like 1
chr17_+_39200302 18.80 ENST00000579374.5
ribosomal protein L19
chr7_+_12686849 18.80 ENST00000396662.5
ENST00000356797.7
ENST00000396664.2
ADP ribosylation factor like GTPase 4A
chr11_-_86068929 18.74 ENST00000630913.2
phosphatidylinositol binding clathrin assembly protein
chr14_-_21383989 18.73 ENST00000216297.7
SPT16 homolog, facilitates chromatin remodeling subunit
chr4_+_56436131 18.41 ENST00000399688.7
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr1_-_110407942 18.08 ENST00000256644.8
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
chr17_-_7315084 18.08 ENST00000570780.5
G protein pathway suppressor 2
chr19_-_8321354 18.06 ENST00000301457.3
NADH:ubiquinone oxidoreductase subunit A7
chr3_+_50617119 17.97 ENST00000430409.5
ENST00000621469.5
ENST00000357955.6
MAPK activated protein kinase 3
chr17_+_57085714 17.96 ENST00000571629.5
ENST00000570423.5
ENST00000575186.5
ENST00000621116.4
ENST00000573085.1
ENST00000572814.1
A-kinase anchoring protein 1
chr10_+_123154414 17.96 ENST00000368858.9
BUB3 mitotic checkpoint protein
chr19_+_14433284 17.79 ENST00000242783.11
protein kinase N1
chr12_+_53252085 17.71 ENST00000329548.5
major facilitator superfamily domain containing 5
chr10_+_74176741 17.69 ENST00000673027.1
ENST00000372734.5
ENST00000541550.6
adenosine kinase
chr8_-_70669142 17.65 ENST00000522447.5
ENST00000276590.5
lactamase beta 2
chr19_+_1067144 17.59 ENST00000313093.7
Rho GTPase activating protein 45
chr1_+_26472405 17.59 ENST00000361427.6
high mobility group nucleosomal binding domain 2
chr2_-_120223371 17.54 ENST00000426077.3
transmembrane protein 185B
chr8_-_8893548 17.46 ENST00000276282.7
malignant fibrous histiocytoma amplified sequence 1
chrX_-_47659128 17.29 ENST00000333119.7
ENST00000335890.3
ubiquitously expressed prefoldin like chaperone
chr6_+_151452447 17.19 ENST00000367294.4
acidic residue methyltransferase 1
chr1_-_3900215 17.01 ENST00000680169.1
ENST00000680535.1
ENST00000361605.4
chromosome 1 open reading frame 174
chr12_+_103965863 16.94 ENST00000392872.8
ENST00000537100.5
thymine DNA glycosylase
chrX_+_41333905 16.80 ENST00000457138.7
ENST00000643821.1
DEAD-box helicase 3 X-linked
chr17_+_51153628 16.73 ENST00000555572.1
ENST00000013034.3
NME1-NME2 readthrough
NME/NM23 nucleoside diphosphate kinase 1
chr10_-_43407769 16.59 ENST00000357065.8
heterogeneous nuclear ribonucleoprotein F
chr10_+_22321056 16.52 ENST00000376663.8
BMI1 proto-oncogene, polycomb ring finger
chr18_+_80109236 16.49 ENST00000262198.9
ENST00000560752.5
ADNP homeobox 2
chr12_-_76083926 16.48 ENST00000551992.5
nucleosome assembly protein 1 like 1
chr17_+_51166398 16.42 ENST00000512737.6
ENST00000503064.5
ENST00000393183.7
NME/NM23 nucleoside diphosphate kinase 2
chr19_+_1067493 16.39 ENST00000586866.5
Rho GTPase activating protein 45
chr6_-_32843994 16.38 ENST00000395339.7
ENST00000374882.8
proteasome 20S subunit beta 8
chr17_-_49414802 16.28 ENST00000511832.6
ENST00000419140.7
ENST00000617874.5
prohibitin
chr6_-_96897853 16.17 ENST00000316149.8
NADH:ubiquinone oxidoreductase complex assembly factor 4
chr19_+_49677228 16.16 ENST00000454376.7
ENST00000524771.5
protein arginine methyltransferase 1
chr12_+_57230086 16.13 ENST00000414700.7
ENST00000557703.5
serine hydroxymethyltransferase 2
chr11_-_123061173 16.12 ENST00000526110.5
ENST00000227378.7
heat shock protein family A (Hsp70) member 8
chr14_-_75176593 16.08 ENST00000303575.9
transmembrane p24 trafficking protein 10
chr13_+_27424583 15.92 ENST00000381140.10
general transcription factor IIIA
chr11_-_64246190 15.70 ENST00000392210.6
protein phosphatase 1 regulatory inhibitor subunit 14B
chr1_-_43172504 15.69 ENST00000431635.6
EBNA1 binding protein 2
chr8_+_22367259 15.67 ENST00000520644.1
ENST00000359741.10
ENST00000381237.6
ENST00000240095.10
solute carrier family 39 member 14
chr1_+_26472459 15.65 ENST00000619352.4
high mobility group nucleosomal binding domain 2
chr10_+_68956158 15.58 ENST00000354185.9
DExD-box helicase 21
chr17_-_49414871 15.57 ENST00000504124.6
ENST00000300408.8
ENST00000614445.5
prohibitin
chr16_-_28491996 15.56 ENST00000568497.6
ENST00000357857.14
ENST00000395653.9
ENST00000635973.1
ENST00000568443.2
ENST00000568558.6
ENST00000565688.5
ENST00000637100.1
ENST00000359984.12
ENST00000636147.2
ENST00000567963.6
CLN3 lysosomal/endosomal transmembrane protein, battenin
chr7_+_100673823 15.47 ENST00000419828.5
ENST00000427895.5
G protein subunit beta 2
chr7_+_100673732 15.46 ENST00000303210.9
ENST00000436220.5
ENST00000424361.5
G protein subunit beta 2
chr11_+_844067 15.42 ENST00000397406.5
ENST00000409543.6
ENST00000525201.5
tetraspanin 4
chr14_-_65102468 15.40 ENST00000555932.5
ENST00000284165.10
ENST00000358402.8
ENST00000246163.2
ENST00000358664.9
ENST00000556979.5
ENST00000555667.5
ENST00000557746.5
ENST00000556443.5
ENST00000618858.4
ENST00000557277.5
ENST00000556892.5
MYC associated factor X
chr19_-_5719849 15.27 ENST00000590729.5
lon peptidase 1, mitochondrial

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
83.3 416.6 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
28.7 86.0 GO:0097698 telomere maintenance via base-excision repair(GO:0097698)
27.1 135.7 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
22.1 66.4 GO:0046452 dihydrofolate metabolic process(GO:0046452)
19.7 59.2 GO:0002368 B cell cytokine production(GO:0002368)
17.0 68.0 GO:0009216 adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216)
13.6 81.5 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
13.4 40.1 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
12.1 48.5 GO:0000961 negative regulation of mitochondrial RNA catabolic process(GO:0000961)
12.1 36.3 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
11.5 46.0 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
11.0 110.3 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
10.8 97.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
10.7 32.1 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
10.6 31.7 GO:0090149 mitochondrial membrane fission(GO:0090149)
10.0 40.2 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
9.5 28.5 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
9.4 28.2 GO:1902905 positive regulation of fibril organization(GO:1902905)
8.7 8.7 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
8.2 24.7 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
8.2 73.9 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
8.2 24.6 GO:0043323 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
8.0 24.1 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
8.0 31.9 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
8.0 31.8 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
7.9 23.7 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
7.8 23.5 GO:2000176 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
7.8 54.6 GO:1902416 positive regulation of mRNA binding(GO:1902416)
7.7 23.2 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
7.6 22.9 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
7.6 61.0 GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
7.6 76.2 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
7.3 22.0 GO:0006059 hexitol metabolic process(GO:0006059)
7.3 21.9 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
7.0 20.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
6.8 34.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
6.8 88.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
6.5 19.5 GO:1901355 response to rapamycin(GO:1901355)
6.4 83.2 GO:0021769 orbitofrontal cortex development(GO:0021769)
6.2 18.6 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
6.2 24.7 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
6.1 49.1 GO:0016139 glycoside catabolic process(GO:0016139)
5.9 17.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
5.8 51.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
5.5 109.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
5.5 27.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
5.5 21.9 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
5.1 30.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
5.0 20.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
4.9 24.6 GO:0006344 maintenance of chromatin silencing(GO:0006344)
4.6 18.6 GO:0043335 protein unfolding(GO:0043335)
4.6 22.8 GO:0014886 transition between slow and fast fiber(GO:0014886)
4.4 17.8 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
4.4 30.8 GO:0046985 histone H4-R3 methylation(GO:0043985) negative regulation of megakaryocyte differentiation(GO:0045653) positive regulation of hemoglobin biosynthetic process(GO:0046985)
4.4 39.6 GO:0042256 mature ribosome assembly(GO:0042256)
4.3 85.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
4.0 16.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
3.9 11.8 GO:0007174 epidermal growth factor catabolic process(GO:0007174)
3.9 11.8 GO:0036245 cellular response to menadione(GO:0036245)
3.9 11.8 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
3.9 11.7 GO:0031938 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
3.9 15.5 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
3.8 7.7 GO:0090402 oncogene-induced cell senescence(GO:0090402)
3.8 11.5 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
3.8 7.6 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
3.8 30.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
3.8 15.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
3.8 11.3 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
3.7 7.4 GO:0006166 purine ribonucleoside salvage(GO:0006166)
3.6 28.6 GO:0060155 platelet dense granule organization(GO:0060155)
3.5 20.8 GO:0016321 female meiosis chromosome segregation(GO:0016321)
3.4 30.8 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
3.4 44.4 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
3.4 10.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
3.4 10.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
3.4 6.7 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
3.4 6.7 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
3.2 9.7 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
3.2 16.1 GO:0061738 late endosomal microautophagy(GO:0061738) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
3.1 31.4 GO:0045008 depyrimidination(GO:0045008)
3.1 9.3 GO:1903093 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
3.1 43.0 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
3.0 15.0 GO:0006740 NADPH regeneration(GO:0006740)
3.0 26.9 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
3.0 6.0 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
3.0 26.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
2.9 23.0 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
2.9 14.3 GO:0031291 Ran protein signal transduction(GO:0031291)
2.8 42.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
2.8 8.4 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
2.8 169.3 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
2.8 8.3 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
2.8 35.8 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
2.7 18.8 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
2.7 10.7 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
2.7 10.6 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
2.6 28.4 GO:0006552 leucine catabolic process(GO:0006552)
2.6 18.0 GO:0044351 macropinocytosis(GO:0044351)
2.5 22.4 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
2.5 74.5 GO:0090383 phagosome acidification(GO:0090383)
2.5 9.9 GO:0019348 dolichol metabolic process(GO:0019348)
2.5 7.4 GO:0006167 AMP biosynthetic process(GO:0006167)
2.5 12.3 GO:0009213 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
2.5 19.6 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
2.4 12.2 GO:0072423 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
2.4 26.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
2.3 16.4 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
2.3 37.0 GO:0006228 UTP biosynthetic process(GO:0006228)
2.3 6.8 GO:1902594 viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594)
2.3 145.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
2.2 20.2 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
2.2 6.6 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
2.2 11.0 GO:0016240 autophagosome docking(GO:0016240)
2.1 15.0 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
2.1 19.2 GO:1902570 protein localization to nucleolus(GO:1902570)
2.1 6.3 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
2.1 10.5 GO:0030043 actin filament fragmentation(GO:0030043)
2.1 6.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
2.1 14.4 GO:0000255 allantoin metabolic process(GO:0000255)
2.0 12.3 GO:0048254 snoRNA localization(GO:0048254)
2.0 8.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
2.0 26.0 GO:1901072 glucosamine-containing compound catabolic process(GO:1901072)
2.0 10.0 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
1.9 17.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
1.9 11.4 GO:0015680 intracellular copper ion transport(GO:0015680)
1.9 9.5 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
1.9 22.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
1.9 5.6 GO:0045556 TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556)
1.9 18.5 GO:0048368 lateral mesoderm development(GO:0048368)
1.9 9.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.8 271.5 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
1.8 28.5 GO:0009125 nucleoside monophosphate catabolic process(GO:0009125)
1.8 8.8 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
1.7 8.7 GO:1901159 xylulose metabolic process(GO:0005997) glucuronate catabolic process(GO:0006064) glucuronate catabolic process to xylulose 5-phosphate(GO:0019640) xylulose 5-phosphate metabolic process(GO:0051167) xylulose 5-phosphate biosynthetic process(GO:1901159)
1.7 20.8 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
1.7 20.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
1.7 12.1 GO:0072553 terminal button organization(GO:0072553)
1.7 5.1 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
1.6 1.6 GO:0072387 flavin adenine dinucleotide metabolic process(GO:0072387)
1.6 6.6 GO:0051182 coenzyme transport(GO:0051182)
1.6 6.5 GO:0072719 smooth muscle hyperplasia(GO:0014806) cellular response to cisplatin(GO:0072719)
1.6 4.8 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
1.6 28.2 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
1.6 4.7 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
1.6 4.7 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.5 34.0 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
1.5 68.9 GO:2000816 negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of mitotic sister chromatid separation(GO:2000816)
1.5 25.7 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
1.5 15.0 GO:0040016 embryonic cleavage(GO:0040016)
1.5 9.0 GO:2000253 positive regulation of feeding behavior(GO:2000253)
1.5 4.4 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.4 21.5 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
1.4 11.3 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
1.4 5.6 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
1.4 20.8 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
1.4 6.9 GO:0007042 lysosomal lumen acidification(GO:0007042)
1.4 15.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
1.4 13.8 GO:0051451 myoblast migration(GO:0051451)
1.3 18.7 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
1.3 10.6 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
1.3 6.6 GO:2000110 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
1.3 1.3 GO:0014734 skeletal muscle hypertrophy(GO:0014734)
1.3 1.3 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
1.3 3.8 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
1.3 5.0 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
1.2 12.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
1.2 23.3 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
1.2 8.5 GO:0008295 spermidine biosynthetic process(GO:0008295)
1.2 3.6 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
1.2 3.6 GO:0035910 endocardial cushion fusion(GO:0003274) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) uterine wall breakdown(GO:0042704)
1.2 30.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
1.2 4.7 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
1.2 26.8 GO:0030488 tRNA methylation(GO:0030488)
1.2 12.7 GO:2001169 regulation of ATP biosynthetic process(GO:2001169) positive regulation of ATP biosynthetic process(GO:2001171)
1.1 25.0 GO:0008334 histone mRNA metabolic process(GO:0008334)
1.1 29.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
1.1 24.8 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
1.1 11.3 GO:0008298 intracellular mRNA localization(GO:0008298)
1.1 24.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
1.1 8.9 GO:0044206 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
1.1 10.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
1.1 41.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
1.1 4.4 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
1.1 63.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
1.1 4.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
1.1 4.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
1.1 1.1 GO:0060003 copper ion export(GO:0060003)
1.1 5.4 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
1.1 3.2 GO:0036233 glycine import(GO:0036233)
1.0 3.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
1.0 19.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
1.0 13.3 GO:0032025 response to cobalt ion(GO:0032025)
1.0 10.1 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
1.0 13.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.0 16.0 GO:0042340 keratan sulfate catabolic process(GO:0042340)
1.0 3.9 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
1.0 6.7 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.9 39.2 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.9 116.5 GO:0006364 rRNA processing(GO:0006364)
0.9 3.7 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.9 15.1 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
0.9 5.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.9 7.0 GO:2000210 positive regulation of anoikis(GO:2000210)
0.9 7.9 GO:0070459 prolactin secretion(GO:0070459)
0.9 8.7 GO:0006983 ER overload response(GO:0006983)
0.9 8.5 GO:0006294 nucleotide-excision repair, preincision complex assembly(GO:0006294)
0.9 11.1 GO:0002115 store-operated calcium entry(GO:0002115)
0.8 2.5 GO:1901389 regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
0.8 24.0 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.8 44.6 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.8 2.5 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.8 2.5 GO:0001188 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.8 51.2 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.8 45.1 GO:0006334 nucleosome assembly(GO:0006334)
0.8 6.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.8 61.7 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.8 5.5 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) histone H2A K63-linked ubiquitination(GO:0070535) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.8 57.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.7 6.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.7 5.9 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902235)
0.7 5.1 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.7 5.8 GO:0007549 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.7 6.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.7 14.8 GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893)
0.7 12.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.7 26.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.7 2.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.7 2.8 GO:0030961 peptidyl-arginine hydroxylation(GO:0030961)
0.7 2.1 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.7 8.9 GO:0090161 Golgi ribbon formation(GO:0090161)
0.7 46.3 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.7 14.0 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.7 11.3 GO:0003334 keratinocyte development(GO:0003334)
0.7 5.3 GO:0033484 regulation of protein ADP-ribosylation(GO:0010835) nitric oxide homeostasis(GO:0033484)
0.7 7.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.7 5.3 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.6 29.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.6 1.9 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.6 17.3 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.6 19.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.6 1.2 GO:0061113 pancreas morphogenesis(GO:0061113)
0.6 4.9 GO:0006450 regulation of translational fidelity(GO:0006450)
0.6 15.3 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.6 62.2 GO:0070527 platelet aggregation(GO:0070527)
0.6 2.4 GO:0032907 B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
0.6 10.2 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.6 50.4 GO:0043297 apical junction assembly(GO:0043297)
0.6 5.3 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.6 8.5 GO:0006105 succinate metabolic process(GO:0006105)
0.6 26.0 GO:1901998 toxin transport(GO:1901998)
0.6 2.3 GO:0015677 copper ion import(GO:0015677)
0.6 3.4 GO:0006689 ganglioside catabolic process(GO:0006689)
0.6 40.1 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349)
0.6 3.3 GO:0050893 sensory processing(GO:0050893)
0.5 6.6 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.5 39.3 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.5 4.9 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237)
0.5 26.7 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.5 32.5 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.5 17.3 GO:0001881 receptor recycling(GO:0001881)
0.5 2.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.5 1.0 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605) negative regulation of keratinocyte differentiation(GO:0045617)
0.5 5.5 GO:0016180 snRNA processing(GO:0016180)
0.5 3.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.5 8.9 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.5 15.8 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.5 8.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.5 5.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.5 12.7 GO:0006754 ATP biosynthetic process(GO:0006754)
0.5 4.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.4 5.7 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.4 4.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.4 18.3 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.4 4.5 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.4 5.7 GO:0032836 glomerular basement membrane development(GO:0032836)
0.4 9.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.4 17.7 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.4 18.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.4 22.9 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.4 28.1 GO:0048678 response to axon injury(GO:0048678)
0.4 16.5 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.4 1.1 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.4 1.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.4 8.2 GO:0006491 N-glycan processing(GO:0006491)
0.4 5.2 GO:0036010 protein localization to endosome(GO:0036010)
0.4 1.8 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) peptidyl-arginine omega-N-methylation(GO:0035247)
0.4 11.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 2.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.3 1.4 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.3 38.1 GO:0006414 translational elongation(GO:0006414)
0.3 21.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 7.2 GO:0031639 plasminogen activation(GO:0031639)
0.3 3.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 2.8 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 5.5 GO:0032402 melanosome transport(GO:0032402)
0.3 3.0 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.3 10.1 GO:0070207 protein homotrimerization(GO:0070207)
0.3 1.9 GO:0042255 ribosome assembly(GO:0042255)
0.3 20.8 GO:0032272 negative regulation of protein polymerization(GO:0032272)
0.3 26.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.3 4.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.3 26.4 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.3 5.7 GO:0002021 response to dietary excess(GO:0002021)
0.3 4.3 GO:0070723 response to cholesterol(GO:0070723)
0.3 18.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.3 6.3 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.3 3.6 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.3 11.6 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.3 5.3 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.3 3.9 GO:0048535 lymph node development(GO:0048535)
0.3 2.6 GO:0000338 protein deneddylation(GO:0000338)
0.3 3.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.3 3.8 GO:0015889 cobalamin transport(GO:0015889)
0.3 5.5 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.2 1.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.2 2.9 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.2 3.4 GO:0006020 inositol metabolic process(GO:0006020)
0.2 1.9 GO:0044030 regulation of DNA methylation(GO:0044030)
0.2 8.5 GO:0061462 protein localization to lysosome(GO:0061462)
0.2 2.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 0.9 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.2 0.7 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.2 1.6 GO:0043928 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.2 2.3 GO:0006853 carnitine shuttle(GO:0006853)
0.2 13.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 0.8 GO:0033306 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
0.2 2.8 GO:0001778 plasma membrane repair(GO:0001778)
0.2 34.2 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.2 2.5 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.2 6.5 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 4.6 GO:1903831 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 53.7 GO:0010038 response to metal ion(GO:0010038)
0.2 7.5 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 1.9 GO:0051601 exocyst localization(GO:0051601)
0.2 2.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.2 6.4 GO:1902400 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)
0.2 2.8 GO:0097264 self proteolysis(GO:0097264)
0.2 86.4 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.2 2.7 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.2 3.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 9.2 GO:0006401 RNA catabolic process(GO:0006401)
0.2 3.9 GO:0006400 tRNA modification(GO:0006400)
0.2 2.6 GO:0034453 microtubule anchoring(GO:0034453)
0.2 8.1 GO:0015701 bicarbonate transport(GO:0015701)
0.1 3.7 GO:0031648 protein destabilization(GO:0031648)
0.1 4.7 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.1 1.0 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 1.1 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.1 5.3 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.1 2.3 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.9 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 2.5 GO:0006308 DNA catabolic process(GO:0006308)
0.1 1.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 8.7 GO:0002576 platelet degranulation(GO:0002576)
0.1 5.1 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 1.6 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 1.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.5 GO:0071895 odontoblast differentiation(GO:0071895)
0.1 2.6 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 0.6 GO:0042976 activation of Janus kinase activity(GO:0042976)
0.1 0.5 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 8.0 GO:2001020 regulation of response to DNA damage stimulus(GO:2001020)
0.1 4.3 GO:0006968 cellular defense response(GO:0006968)
0.1 9.7 GO:0050920 regulation of chemotaxis(GO:0050920)
0.1 5.9 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway(GO:2001237)
0.1 12.4 GO:0050851 antigen receptor-mediated signaling pathway(GO:0050851)
0.1 3.6 GO:0019915 lipid storage(GO:0019915)
0.1 1.5 GO:0033198 response to ATP(GO:0033198)
0.1 1.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.5 GO:0060009 Sertoli cell development(GO:0060009)
0.0 1.4 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.6 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 2.0 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.4 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 2.9 GO:0031424 keratinization(GO:0031424)
0.0 0.0 GO:2000679 positive regulation of transcription regulatory region DNA binding(GO:2000679)
0.0 0.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.0 GO:0009750 response to fructose(GO:0009750)
0.0 0.9 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
69.4 416.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
18.5 73.9 GO:0033186 CAF-1 complex(GO:0033186)
15.3 122.8 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
12.2 61.0 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
11.0 109.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
9.9 29.7 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
8.6 25.7 GO:0030906 retromer, cargo-selective complex(GO:0030906)
7.7 46.3 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
7.5 67.8 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
7.4 29.6 GO:0071986 Ragulator complex(GO:0071986)
7.3 21.9 GO:0045323 interleukin-1 receptor complex(GO:0045323)
7.0 48.9 GO:0031415 NatA complex(GO:0031415)
6.9 20.7 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
6.8 88.3 GO:0042555 MCM complex(GO:0042555)
6.6 66.2 GO:0070552 BRISC complex(GO:0070552)
6.4 32.0 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
6.4 44.7 GO:0044530 supraspliceosomal complex(GO:0044530)
6.3 25.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
6.3 56.4 GO:0042382 paraspeckles(GO:0042382)
5.4 21.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
5.4 86.1 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179)
5.3 101.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
5.2 15.5 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
4.9 14.7 GO:0071148 TEAD-1-YAP complex(GO:0071148)
4.8 48.1 GO:0046581 intercellular canaliculus(GO:0046581)
4.7 47.4 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
4.7 14.0 GO:0071817 MMXD complex(GO:0071817)
4.6 22.9 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
4.5 13.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
4.4 17.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
4.3 12.9 GO:1902737 dendritic filopodium(GO:1902737)
4.2 16.8 GO:0034457 Mpp10 complex(GO:0034457)
4.2 83.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
4.1 36.5 GO:0097208 alveolar lamellar body(GO:0097208)
4.0 27.8 GO:1990111 spermatoproteasome complex(GO:1990111)
4.0 75.2 GO:0005641 nuclear envelope lumen(GO:0005641)
3.9 70.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
3.9 11.7 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
3.7 18.6 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
3.7 29.7 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
3.6 43.0 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
3.5 38.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
3.5 55.8 GO:0034709 methylosome(GO:0034709)
3.5 52.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
3.4 41.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
3.3 20.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
3.3 19.7 GO:0032279 asymmetric synapse(GO:0032279)
3.2 38.4 GO:0071203 WASH complex(GO:0071203)
3.0 14.9 GO:0016589 NURF complex(GO:0016589)
2.7 13.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
2.7 18.8 GO:0032021 NELF complex(GO:0032021)
2.6 23.1 GO:0000439 core TFIIH complex(GO:0000439)
2.6 38.4 GO:0031083 BLOC-1 complex(GO:0031083)
2.5 7.4 GO:0030689 Noc complex(GO:0030689)
2.4 114.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.4 26.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
2.3 39.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
2.3 41.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
2.3 11.3 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
2.1 29.3 GO:0090543 Flemming body(GO:0090543)
2.0 73.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
2.0 10.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
2.0 215.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.0 9.9 GO:0043564 Ku70:Ku80 complex(GO:0043564)
2.0 7.8 GO:0005899 insulin receptor complex(GO:0005899)
2.0 9.8 GO:0033503 HULC complex(GO:0033503)
1.9 23.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
1.9 14.9 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
1.9 7.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
1.6 11.5 GO:0030905 retromer, tubulation complex(GO:0030905)
1.6 19.6 GO:0097413 Lewy body(GO:0097413)
1.6 4.8 GO:0044611 nuclear pore inner ring(GO:0044611)
1.6 4.7 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.6 12.4 GO:0070761 pre-snoRNP complex(GO:0070761)
1.6 57.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
1.5 9.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.5 4.5 GO:0071001 U4/U6 snRNP(GO:0071001)
1.5 32.0 GO:0071141 SMAD protein complex(GO:0071141)
1.4 5.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.4 9.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.3 5.4 GO:0005960 glycine cleavage complex(GO:0005960)
1.3 4.0 GO:1903349 omegasome membrane(GO:1903349)
1.3 10.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.3 10.1 GO:0061700 GATOR2 complex(GO:0061700)
1.3 40.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
1.3 20.0 GO:0035102 PRC1 complex(GO:0035102)
1.2 7.0 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
1.2 137.6 GO:0035578 azurophil granule lumen(GO:0035578)
1.2 4.6 GO:0008537 proteasome activator complex(GO:0008537)
1.1 5.7 GO:0000243 commitment complex(GO:0000243)
1.1 17.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.1 161.3 GO:0016605 PML body(GO:0016605)
1.1 21.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
1.1 207.9 GO:0005840 ribosome(GO:0005840)
1.0 6.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.0 7.3 GO:0031298 replication fork protection complex(GO:0031298)
1.0 17.0 GO:1990909 Wnt signalosome(GO:1990909)
0.9 9.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.9 5.5 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.9 8.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.9 14.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.8 6.7 GO:0030686 90S preribosome(GO:0030686)
0.8 2.5 GO:1990913 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
0.8 4.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.8 17.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.8 21.8 GO:0000178 exosome (RNase complex)(GO:0000178)
0.8 8.6 GO:0005638 lamin filament(GO:0005638)
0.8 7.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.7 5.8 GO:0030532 small nuclear ribonucleoprotein complex(GO:0030532)
0.7 8.7 GO:0000815 ESCRT III complex(GO:0000815)
0.7 50.6 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.7 92.2 GO:0005882 intermediate filament(GO:0005882)
0.7 3.5 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.7 22.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.7 2.7 GO:0035841 growing cell tip(GO:0035838) new growing cell tip(GO:0035841)
0.7 6.0 GO:0000813 ESCRT I complex(GO:0000813)
0.6 1.9 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.6 6.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.6 3.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.6 8.9 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.5 4.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.5 5.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.5 10.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.5 1.6 GO:0055087 Ski complex(GO:0055087)
0.5 44.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.5 3.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.5 7.8 GO:0032040 small-subunit processome(GO:0032040)
0.5 58.1 GO:0070821 tertiary granule membrane(GO:0070821)
0.5 5.5 GO:0032039 integrator complex(GO:0032039)
0.5 22.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.5 5.1 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.5 30.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.4 39.8 GO:0005643 nuclear pore(GO:0005643)
0.4 79.8 GO:0005681 spliceosomal complex(GO:0005681)
0.4 2.0 GO:0032044 DSIF complex(GO:0032044)
0.4 8.8 GO:0098800 inner mitochondrial membrane protein complex(GO:0098800)
0.3 2.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.3 1.4 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.3 28.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 25.2 GO:0031594 neuromuscular junction(GO:0031594)
0.3 46.5 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.3 11.3 GO:0002102 podosome(GO:0002102)
0.3 2.7 GO:0001520 outer dense fiber(GO:0001520)
0.3 1.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.3 27.4 GO:0016459 myosin complex(GO:0016459)
0.3 14.0 GO:0000502 proteasome complex(GO:0000502)
0.3 8.7 GO:0005902 microvillus(GO:0005902)
0.3 0.8 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 1.2 GO:0005827 polar microtubule(GO:0005827)
0.2 21.2 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.2 27.8 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 21.0 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.2 3.5 GO:0097433 dense body(GO:0097433)
0.2 7.8 GO:0016592 mediator complex(GO:0016592)
0.2 5.1 GO:0032420 stereocilium(GO:0032420)
0.2 13.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 10.4 GO:0031526 brush border membrane(GO:0031526)
0.2 5.6 GO:0005903 brush border(GO:0005903)
0.2 9.0 GO:0035580 specific granule lumen(GO:0035580)
0.2 11.0 GO:0031966 mitochondrial membrane(GO:0031966)
0.1 3.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 3.0 GO:0000776 kinetochore(GO:0000776)
0.1 6.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 42.3 GO:0016324 apical plasma membrane(GO:0016324)
0.1 4.4 GO:0043034 costamere(GO:0043034)
0.1 3.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.0 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 3.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 15.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 13.5 GO:0008021 synaptic vesicle(GO:0008021)
0.1 20.9 GO:0019866 organelle inner membrane(GO:0019866)
0.1 2.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 2.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 67.8 GO:0005730 nucleolus(GO:0005730)
0.1 2.7 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.3 GO:0005771 multivesicular body(GO:0005771)
0.1 5.0 GO:0005581 collagen trimer(GO:0005581)
0.0 6.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.8 GO:0030496 midbody(GO:0030496)
0.0 9.6 GO:0010008 endosome membrane(GO:0010008)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.3 GO:0072686 mitotic spindle(GO:0072686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
21.5 86.0 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
17.1 34.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
17.0 68.0 GO:0004001 adenosine kinase activity(GO:0004001)
16.8 83.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
14.9 44.6 GO:0016936 galactoside binding(GO:0016936)
14.1 42.3 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
13.8 110.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
13.6 81.5 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
13.4 40.2 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
13.4 40.1 GO:0070362 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
12.2 109.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
11.0 55.0 GO:0031871 proteinase activated receptor binding(GO:0031871)
10.8 420.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
10.7 64.0 GO:0019238 cyclohydrolase activity(GO:0019238)
9.9 59.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
9.4 28.3 GO:0004638 phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
9.1 36.3 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
8.2 24.7 GO:0004730 pseudouridylate synthase activity(GO:0004730)
7.3 21.9 GO:0008859 exoribonuclease II activity(GO:0008859)
6.9 27.6 GO:0042134 rRNA primary transcript binding(GO:0042134)
6.7 20.1 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
6.7 93.4 GO:0031386 protein tag(GO:0031386)
6.2 24.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
5.6 44.7 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
5.4 26.8 GO:0097322 7SK snRNA binding(GO:0097322)
5.3 26.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
5.2 20.6 GO:0043273 CTPase activity(GO:0043273)
5.1 30.8 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
5.1 20.5 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
5.0 15.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
4.9 19.7 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
4.9 24.5 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
4.9 48.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
4.7 23.7 GO:0019776 Atg8 ligase activity(GO:0019776)
4.4 17.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
4.4 84.4 GO:0019215 intermediate filament binding(GO:0019215)
4.4 61.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
4.2 25.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
4.0 31.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
3.8 22.9 GO:0035500 MH2 domain binding(GO:0035500)
3.7 18.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
3.7 29.7 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
3.6 10.9 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702) oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
3.5 20.7 GO:0036033 mediator complex binding(GO:0036033)
3.4 20.7 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
3.4 17.2 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
3.4 10.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
3.4 23.8 GO:0001849 complement component C1q binding(GO:0001849)
3.4 10.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
3.3 43.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
3.3 152.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
3.3 13.0 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
2.9 17.4 GO:0019826 oxygen sensor activity(GO:0019826)
2.9 23.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
2.8 8.5 GO:0004766 spermidine synthase activity(GO:0004766)
2.8 8.3 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
2.8 74.5 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
2.8 8.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
2.6 84.5 GO:0051059 NF-kappaB binding(GO:0051059)
2.6 13.1 GO:1990460 leptin receptor binding(GO:1990460)
2.6 15.7 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
2.6 20.7 GO:0015288 porin activity(GO:0015288)
2.6 61.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
2.6 128.8 GO:0016831 carboxy-lyase activity(GO:0016831)
2.5 15.0 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
2.5 9.9 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
2.5 19.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
2.4 7.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
2.4 16.5 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
2.3 45.4 GO:0042609 CD4 receptor binding(GO:0042609)
2.3 33.8 GO:0003688 DNA replication origin binding(GO:0003688)
2.2 22.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
2.2 8.9 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
2.2 4.4 GO:0004167 dopachrome isomerase activity(GO:0004167)
2.2 13.2 GO:1990446 U1 snRNP binding(GO:1990446)
2.2 56.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
2.1 22.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
2.0 12.2 GO:0048256 flap endonuclease activity(GO:0048256)
2.0 28.2 GO:0000339 RNA cap binding(GO:0000339)
2.0 28.0 GO:0008097 5S rRNA binding(GO:0008097)
1.9 13.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.9 9.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.9 11.6 GO:0004301 epoxide hydrolase activity(GO:0004301)
1.9 23.2 GO:0051434 BH3 domain binding(GO:0051434)
1.9 5.6 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.9 5.6 GO:0004566 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
1.8 5.4 GO:0004047 aminomethyltransferase activity(GO:0004047)
1.7 137.7 GO:0005507 copper ion binding(GO:0005507)
1.7 10.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
1.7 31.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
1.7 107.2 GO:0003743 translation initiation factor activity(GO:0003743)
1.7 8.5 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.7 5.1 GO:0052839 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
1.7 6.7 GO:0043024 ribosomal small subunit binding(GO:0043024)
1.7 41.9 GO:0003746 translation elongation factor activity(GO:0003746)
1.6 44.5 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
1.6 29.6 GO:0016018 cyclosporin A binding(GO:0016018)
1.6 11.3 GO:0000182 rDNA binding(GO:0000182)
1.6 11.3 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
1.6 51.2 GO:0042288 MHC class I protein binding(GO:0042288)
1.6 7.8 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
1.5 9.3 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
1.5 14.8 GO:0032552 deoxyribonucleotide binding(GO:0032552)
1.5 13.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
1.5 31.0 GO:0048156 tau protein binding(GO:0048156)
1.5 29.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
1.5 16.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
1.5 4.4 GO:0004056 argininosuccinate lyase activity(GO:0004056)
1.5 4.4 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
1.5 21.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
1.4 20.0 GO:0019534 toxin transporter activity(GO:0019534)
1.4 11.4 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
1.4 9.9 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
1.4 42.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
1.4 19.5 GO:0003680 AT DNA binding(GO:0003680)
1.4 8.1 GO:0005047 signal recognition particle binding(GO:0005047)
1.3 44.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
1.3 13.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
1.3 9.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.3 10.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.3 28.5 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
1.3 29.8 GO:0031491 nucleosome binding(GO:0031491)
1.3 6.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
1.3 43.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.3 58.5 GO:0048487 beta-tubulin binding(GO:0048487)
1.3 2.5 GO:0004530 deoxyribonuclease I activity(GO:0004530)
1.3 25.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
1.3 35.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
1.2 7.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
1.2 11.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
1.2 6.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
1.2 21.5 GO:0097016 L27 domain binding(GO:0097016)
1.1 51.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
1.1 4.5 GO:0004348 glucosylceramidase activity(GO:0004348)
1.1 17.7 GO:0001054 RNA polymerase I activity(GO:0001054)
1.1 12.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.1 14.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
1.1 6.4 GO:0003998 acylphosphatase activity(GO:0003998)
1.1 25.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
1.1 2.1 GO:0000403 Y-form DNA binding(GO:0000403)
1.0 8.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
1.0 7.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
1.0 20.6 GO:0003924 GTPase activity(GO:0003924)
1.0 4.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
1.0 18.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
1.0 19.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.0 3.9 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
1.0 198.2 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 44.8 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.9 33.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.9 3.7 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.9 18.1 GO:0004697 protein kinase C activity(GO:0004697)
0.9 17.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.9 8.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.9 28.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.9 20.5 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.8 7.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.8 7.6 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.8 19.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.8 4.9 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.8 8.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.8 11.1 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.7 14.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.7 13.1 GO:0043274 phospholipase binding(GO:0043274)
0.7 3.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.7 11.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.7 3.4 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.7 5.4 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.7 4.7 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.7 4.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 5.9 GO:0089720 caspase binding(GO:0089720)
0.7 62.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.6 16.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.6 3.9 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.6 16.5 GO:0070064 proline-rich region binding(GO:0070064)
0.6 2.5 GO:0019770 IgG receptor activity(GO:0019770)
0.6 6.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.6 77.0 GO:0008565 protein transporter activity(GO:0008565)
0.6 6.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.6 4.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.6 12.7 GO:0070061 fructose binding(GO:0070061)
0.6 2.3 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.6 37.2 GO:0003684 damaged DNA binding(GO:0003684)
0.5 51.8 GO:0032947 protein complex scaffold(GO:0032947)
0.5 6.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.5 14.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.5 6.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.5 3.0 GO:0004046 aminoacylase activity(GO:0004046)
0.5 11.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.5 2.4 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.5 3.8 GO:0070878 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) primary miRNA binding(GO:0070878)
0.5 11.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.5 4.7 GO:0070569 uridylyltransferase activity(GO:0070569)
0.5 7.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.5 35.4 GO:0019003 GDP binding(GO:0019003)
0.5 3.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.5 6.5 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.5 7.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.5 2.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.4 9.0 GO:0030515 snoRNA binding(GO:0030515)
0.4 17.7 GO:0004521 endoribonuclease activity(GO:0004521)
0.4 4.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 1.2 GO:0031208 POZ domain binding(GO:0031208)
0.4 2.8 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.4 3.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 5.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.4 5.7 GO:0008517 folic acid transporter activity(GO:0008517)
0.4 5.6 GO:0048406 nerve growth factor binding(GO:0048406)
0.3 9.3 GO:0042605 peptide antigen binding(GO:0042605)
0.3 9.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 7.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 3.3 GO:0015643 toxic substance binding(GO:0015643)
0.3 14.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 23.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 4.8 GO:0004985 opioid receptor activity(GO:0004985)
0.3 18.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.3 2.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.3 17.8 GO:0019213 deacetylase activity(GO:0019213)
0.3 0.9 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.3 11.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 4.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 25.9 GO:0043130 ubiquitin binding(GO:0043130)
0.3 1.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 2.9 GO:0003993 acid phosphatase activity(GO:0003993)
0.3 2.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.3 2.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 12.5 GO:0030145 manganese ion binding(GO:0030145)
0.3 58.1 GO:0051015 actin filament binding(GO:0051015)
0.3 0.8 GO:0046577 long-chain-alcohol oxidase activity(GO:0046577)
0.3 5.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 5.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 27.0 GO:0001618 virus receptor activity(GO:0001618)
0.3 2.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.3 2.8 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.2 16.5 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.2 35.2 GO:0005178 integrin binding(GO:0005178)
0.2 7.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.2 15.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 6.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 3.7 GO:0001968 fibronectin binding(GO:0001968)
0.2 2.6 GO:0043022 ribosome binding(GO:0043022)
0.2 5.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 11.9 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.2 5.1 GO:0003785 actin monomer binding(GO:0003785)
0.2 7.5 GO:0008009 chemokine activity(GO:0008009)
0.2 1.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 1.6 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 1.5 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 3.7 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 0.6 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 0.5 GO:0016295 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420) phosphopantetheine binding(GO:0031177)
0.2 1.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 0.9 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.4 GO:0004461 lactose synthase activity(GO:0004461)
0.1 1.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 32.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 4.8 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 4.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.9 GO:0098821 BMP receptor activity(GO:0098821)
0.1 1.5 GO:0031419 cobalamin binding(GO:0031419)
0.1 16.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 10.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.1 GO:0001972 retinoic acid binding(GO:0001972)
0.1 4.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 77.8 GO:0003723 RNA binding(GO:0003723)
0.1 6.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 10.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 2.2 GO:0005179 hormone activity(GO:0005179)
0.0 6.9 GO:0005525 GTP binding(GO:0005525)
0.0 0.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
20.9 417.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
3.0 425.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
2.9 147.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
2.1 40.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.9 98.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
1.6 83.8 PID ATR PATHWAY ATR signaling pathway
1.4 114.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
1.3 9.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.2 55.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
1.2 99.8 PID RAC1 PATHWAY RAC1 signaling pathway
1.1 86.7 PID ILK PATHWAY Integrin-linked kinase signaling
1.1 7.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.7 33.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.7 51.2 PID E2F PATHWAY E2F transcription factor network
0.6 19.7 PID ATM PATHWAY ATM pathway
0.6 43.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.6 9.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.5 24.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.5 18.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.5 35.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.4 7.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.4 35.3 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.4 8.4 PID IL2 1PATHWAY IL2-mediated signaling events
0.4 17.2 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.4 8.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.4 9.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 1.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.3 91.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 47.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.3 29.4 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.3 24.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.3 8.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.3 12.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 17.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.3 20.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.3 6.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 15.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.2 12.0 PID AP1 PATHWAY AP-1 transcription factor network
0.2 12.7 PID P73PATHWAY p73 transcription factor network
0.2 4.7 PID ALK1 PATHWAY ALK1 signaling events
0.2 6.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 3.5 PID ARF 3PATHWAY Arf1 pathway
0.2 14.1 PID CMYB PATHWAY C-MYB transcription factor network
0.2 7.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 4.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 2.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.9 PID INSULIN PATHWAY Insulin Pathway
0.1 1.3 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 2.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 1.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 1.3 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.3 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.5 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 415.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
6.9 137.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
6.9 137.0 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
6.7 100.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
6.5 97.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
4.8 109.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
3.8 34.1 REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
3.2 74.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
3.0 71.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
2.7 74.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
2.5 83.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
2.5 37.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
2.5 24.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
2.2 129.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
2.2 416.9 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
2.1 110.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
2.1 12.5 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
2.1 33.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
2.0 163.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
2.0 28.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
1.8 21.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
1.5 9.3 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
1.4 21.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.3 46.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
1.3 22.6 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
1.3 204.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
1.3 22.4 REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX Genes involved in Formation of the HIV-1 Early Elongation Complex
1.3 30.9 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
1.2 3.7 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
1.2 22.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
1.2 121.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
1.1 12.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
1.1 12.7 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
1.1 66.6 REACTOME TRANSLATION Genes involved in Translation
1.0 39.8 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
1.0 37.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
1.0 52.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.9 28.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.9 6.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.9 24.2 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.9 29.8 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.9 28.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.9 6.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.8 14.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.8 4.9 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.7 5.0 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.7 24.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.7 5.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.7 5.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.7 60.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.7 6.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.7 30.2 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.7 16.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.6 2.5 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.6 5.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.6 21.5 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.6 4.8 REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX Genes involved in Formation of RNA Pol II elongation complex
0.6 14.0 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.6 9.9 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.6 5.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.6 8.9 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.5 8.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.5 4.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.5 15.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.5 7.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.5 22.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.4 5.8 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.4 9.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 6.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.4 8.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.4 4.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.4 39.1 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.4 6.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4 7.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 8.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.4 52.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 7.5 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.3 8.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 9.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 12.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3 37.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 4.1 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.3 22.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 5.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 38.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 5.1 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.2 19.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 3.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 4.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 14.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 1.3 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.2 3.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 14.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 4.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 17.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.3 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1 3.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 4.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 5.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 8.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.3 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 0.9 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 4.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 2.4 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.5 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling