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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MEF2B

Z-value: 3.24

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Transcription factors associated with MEF2B

Gene Symbol Gene ID Gene Info
MEF2B
ENSG00000213999.17 MEF2B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Bhg38_v1_chr19_-_19192122_191921650.212.0e-03Click!

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_-_21025000 19.02 ENST00000554489.5
ENST00000555657.5
ENST00000557274.5
ENST00000555158.5
ENST00000554833.5
ENST00000555384.5
ENST00000556420.5
ENST00000554893.5
ENST00000553503.5
ENST00000555733.5
ENST00000397856.7
ENST00000553867.5
ENST00000556147.6
ENST00000556008.5
ENST00000557182.5
ENST00000554483.5
ENST00000556688.5
ENST00000397853.7
ENST00000556329.6
ENST00000397851.6
ENST00000554143.5
ENST00000555142.5
ENST00000557676.5
ENST00000556924.5
NDRG2
NDRG family member 2
chr20_+_10218808 17.43 ENST00000254976.7
ENST00000304886.6
SNAP25
synaptosome associated protein 25
chr8_-_27258414 16.76 ENST00000523048.5
STMN4
stathmin 4
chr14_-_21025490 16.22 ENST00000553442.5
ENST00000555869.5
ENST00000556457.5
ENST00000397844.6
ENST00000554415.5
ENST00000556974.5
ENST00000554419.5
ENST00000298687.9
ENST00000397858.5
ENST00000360463.7
ENST00000350792.7
ENST00000397847.6
NDRG2
NDRG family member 2
chr2_+_232633551 16.14 ENST00000264059.8
EFHD1
EF-hand domain family member D1
chr8_-_27258386 14.89 ENST00000350889.8
ENST00000519997.5
ENST00000519614.5
ENST00000522908.1
ENST00000265770.11
STMN4
stathmin 4
chr2_+_238138661 14.37 ENST00000409223.2
KLHL30
kelch like family member 30
chr12_+_78863962 13.53 ENST00000393240.7
SYT1
synaptotagmin 1
chr12_-_44875647 12.71 ENST00000395487.6
NELL2
neural EGFL like 2
chr20_+_45407207 11.67 ENST00000372712.6
DBNDD2
dysbindin domain containing 2
chr12_+_119178920 10.88 ENST00000281938.7
HSPB8
heat shock protein family B (small) member 8
chr17_+_20155989 10.64 ENST00000395530.6
ENST00000581399.6
ENST00000679819.1
SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr12_+_119178953 10.29 ENST00000674542.1
HSPB8
heat shock protein family B (small) member 8
chr5_-_88883701 9.69 ENST00000636998.1
MEF2C
myocyte enhancer factor 2C
chr19_+_36605292 9.17 ENST00000460670.5
ENST00000292928.7
ENST00000439428.5
ZNF382
zinc finger protein 382
chr14_-_20436161 8.99 ENST00000636854.3
KLHL33
kelch like family member 33
chr12_-_48999363 8.96 ENST00000421952.3
DDN
dendrin
chr5_-_42811884 8.46 ENST00000514985.6
ENST00000511224.5
ENST00000507920.5
ENST00000510965.1
SELENOP
selenoprotein P
chr12_+_52051402 7.86 ENST00000243050.5
ENST00000550763.1
ENST00000394825.6
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4 group A member 1
chr16_+_84294823 7.66 ENST00000568638.1
WFDC1
WAP four-disulfide core domain 1
chr7_-_37448845 7.32 ENST00000310758.9
ELMO1
engulfment and cell motility 1
chr15_+_42359577 7.08 ENST00000357568.8
CAPN3
calpain 3
chr16_+_84294853 7.04 ENST00000219454.10
WFDC1
WAP four-disulfide core domain 1
chr15_+_42359454 6.99 ENST00000349748.8
ENST00000318023.11
ENST00000397163.8
CAPN3
calpain 3
chr2_-_156342348 6.34 ENST00000409572.5
NR4A2
nuclear receptor subfamily 4 group A member 2
chrX_-_47574738 6.11 ENST00000640721.1
SYN1
synapsin I
chr14_-_21537206 6.09 ENST00000614342.1
SALL2
spalt like transcription factor 2
chr13_-_44437214 5.93 ENST00000622051.1
TSC22D1
TSC22 domain family member 1
chr18_+_44680093 5.84 ENST00000426838.8
ENST00000677068.1
SETBP1
SET binding protein 1
chr3_+_138348592 5.84 ENST00000621127.4
ENST00000494949.5
MRAS
muscle RAS oncogene homolog
chr12_-_130716264 5.58 ENST00000643940.1
RIMBP2
RIMS binding protein 2
chr3_+_138348570 5.45 ENST00000423968.7
MRAS
muscle RAS oncogene homolog
chr1_+_76867469 5.26 ENST00000477717.6
ST6GALNAC5
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr9_+_121286115 5.26 ENST00000477104.2
ENST00000394353.7
GSN
gelsolin
chr3_+_138348823 5.16 ENST00000475711.5
ENST00000464896.5
MRAS
muscle RAS oncogene homolog
chr17_+_7281711 4.89 ENST00000317370.13
ENST00000571308.5
SLC2A4
solute carrier family 2 member 4
chr7_+_87152531 4.89 ENST00000432366.6
ENST00000423590.6
ENST00000394703.9
DMTF1
cyclin D binding myb like transcription factor 1
chr11_+_92224801 4.87 ENST00000525166.6
FAT3
FAT atypical cadherin 3
chr1_-_18902520 4.57 ENST00000538839.5
ENST00000290597.9
ENST00000375341.8
ALDH4A1
aldehyde dehydrogenase 4 family member A1
chr8_+_141417902 4.22 ENST00000681443.1
PTP4A3
protein tyrosine phosphatase 4A3
chr11_+_1839602 4.22 ENST00000617947.4
ENST00000252898.11
TNNI2
troponin I2, fast skeletal type
chr5_-_16508788 4.21 ENST00000682142.1
RETREG1
reticulophagy regulator 1
chr5_-_16508990 4.12 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chr2_+_33436304 3.95 ENST00000402538.7
RASGRP3
RAS guanyl releasing protein 3
chr11_+_1839452 3.87 ENST00000381906.5
TNNI2
troponin I2, fast skeletal type
chr22_+_31944527 3.83 ENST00000248975.6
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
chr5_-_16508812 3.82 ENST00000683414.1
RETREG1
reticulophagy regulator 1
chr16_-_31428325 3.73 ENST00000287490.5
COX6A2
cytochrome c oxidase subunit 6A2
chr6_-_69699124 3.67 ENST00000651675.1
LMBRD1
LMBR1 domain containing 1
chr6_-_169253835 3.67 ENST00000649844.1
ENST00000617924.6
THBS2
thrombospondin 2
chr5_-_16508858 3.64 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr5_-_16508951 3.57 ENST00000682628.1
RETREG1
reticulophagy regulator 1
chr7_+_152759744 3.46 ENST00000377776.7
ENST00000256001.13
ENST00000397282.2
ACTR3B
actin related protein 3B
chr9_+_97501622 3.30 ENST00000259365.9
TMOD1
tropomodulin 1
chr22_+_31944500 3.20 ENST00000397492.1
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
chr7_+_30911845 3.16 ENST00000652696.1
ENST00000311813.11
AQP1
aquaporin 1 (Colton blood group)
chr1_+_84164962 2.93 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr6_+_26020442 2.90 ENST00000613854.2
H3C1
H3 clustered histone 1
chr8_+_2045037 2.85 ENST00000262113.9
MYOM2
myomesin 2
chr11_+_1838970 2.71 ENST00000381911.6
TNNI2
troponin I2, fast skeletal type
chrX_-_21758021 2.69 ENST00000646008.1
SMPX
small muscle protein X-linked
chr4_+_71062642 2.63 ENST00000649996.1
SLC4A4
solute carrier family 4 member 4
chr2_+_169509693 2.59 ENST00000284669.2
KLHL41
kelch like family member 41
chr1_-_156490599 2.48 ENST00000360595.7
MEF2D
myocyte enhancer factor 2D
chr12_-_262828 2.47 ENST00000343164.9
ENST00000436453.1
ENST00000445055.6
ENST00000546319.5
SLC6A13
solute carrier family 6 member 13
chr3_+_187021848 2.27 ENST00000440338.5
ENST00000448044.5
ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr12_-_110920568 2.13 ENST00000548438.1
ENST00000228841.15
MYL2
myosin light chain 2
chr8_+_106270161 2.12 ENST00000517566.7
ENST00000531443.6
OXR1
oxidation resistance 1
chr2_+_219253243 2.09 ENST00000490341.3
TUBA4B
tubulin alpha 4b
chr12_-_110920710 2.06 ENST00000546404.1
MYL2
myosin light chain 2
chr3_-_192727500 2.02 ENST00000430714.5
ENST00000418610.1
ENST00000445105.7
ENST00000684728.1
ENST00000448795.5
ENST00000683935.1
ENST00000684282.1
ENST00000683451.1
FGF12
fibroblast growth factor 12
chr4_+_119135825 1.94 ENST00000307128.6
MYOZ2
myozenin 2
chr5_+_54455661 1.88 ENST00000302005.3
HSPB3
heat shock protein family B (small) member 3
chr1_-_114780624 1.86 ENST00000060969.6
ENST00000369528.9
SIKE1
suppressor of IKBKE 1
chr7_-_151519891 1.81 ENST00000262187.10
RHEB
Ras homolog, mTORC1 binding
chr1_+_22451843 1.80 ENST00000375647.5
ENST00000404138.5
ENST00000374651.8
ENST00000400239.6
ZBTB40
zinc finger and BTB domain containing 40
chrX_-_21758097 1.79 ENST00000379494.4
SMPX
small muscle protein X-linked
chr16_+_31214111 1.72 ENST00000322122.8
TRIM72
tripartite motif containing 72
chr15_+_99565950 1.70 ENST00000557785.5
ENST00000558049.5
ENST00000449277.6
MEF2A
myocyte enhancer factor 2A
chr3_+_8501846 1.64 ENST00000454244.4
LMCD1
LIM and cysteine rich domains 1
chr18_+_12407896 1.60 ENST00000590956.5
ENST00000336990.8
ENST00000440960.6
ENST00000588729.5
PRELID3A
PRELI domain containing 3A
chr12_+_25052512 1.57 ENST00000557489.5
ENST00000354454.7
ENST00000536173.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr5_-_132011811 1.49 ENST00000379255.5
ENST00000430403.5
ENST00000357096.5
ACSL6
acyl-CoA synthetase long chain family member 6
chr22_-_50578417 1.49 ENST00000312108.12
ENST00000395650.6
CPT1B
carnitine palmitoyltransferase 1B
chr15_+_99566066 1.48 ENST00000557942.5
MEF2A
myocyte enhancer factor 2A
chr5_-_161547735 1.45 ENST00000675773.1
ENST00000274547.7
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr17_-_44123628 1.38 ENST00000587135.1
ENST00000225983.10
ENST00000682912.1
ENST00000588703.5
HDAC5
histone deacetylase 5
chr1_-_115768702 1.36 ENST00000261448.6
CASQ2
calsequestrin 2
chr19_-_39834127 1.31 ENST00000601972.1
ENST00000430012.6
ENST00000323039.10
ENST00000348817.7
DYRK1B
dual specificity tyrosine phosphorylation regulated kinase 1B
chr4_+_41360759 1.29 ENST00000508501.5
ENST00000512946.5
ENST00000313860.11
ENST00000512632.5
ENST00000512820.5
LIMCH1
LIM and calponin homology domains 1
chr11_-_47352693 1.26 ENST00000256993.8
ENST00000399249.6
ENST00000545968.6
MYBPC3
myosin binding protein C3
chr8_+_2045058 1.26 ENST00000523438.1
MYOM2
myomesin 2
chr11_-_19202004 1.24 ENST00000648719.1
CSRP3
cysteine and glycine rich protein 3
chr17_-_44123590 1.24 ENST00000336057.9
HDAC5
histone deacetylase 5
chr2_-_207165923 1.24 ENST00000309446.11
KLF7
Kruppel like factor 7
chr21_-_40847149 1.22 ENST00000400454.6
DSCAM
DS cell adhesion molecule
chr1_-_26913964 1.19 ENST00000254227.4
NR0B2
nuclear receptor subfamily 0 group B member 2
chr7_+_143316105 1.17 ENST00000343257.7
ENST00000650516.1
CLCN1
chloride voltage-gated channel 1
chr5_-_132011794 1.17 ENST00000650697.1
ACSL6
acyl-CoA synthetase long chain family member 6
chr3_+_159852933 1.14 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr7_-_113919000 1.14 ENST00000284601.4
PPP1R3A
protein phosphatase 1 regulatory subunit 3A
chr15_+_99565921 1.12 ENST00000558812.5
ENST00000338042.10
MEF2A
myocyte enhancer factor 2A
chr11_-_84923403 1.07 ENST00000532653.5
DLG2
discs large MAGUK scaffold protein 2
chr11_-_84923162 1.06 ENST00000524982.5
DLG2
discs large MAGUK scaffold protein 2
chr2_-_210303608 0.98 ENST00000341685.8
MYL1
myosin light chain 1
chr15_+_40239042 0.96 ENST00000558055.5
ENST00000455577.6
PAK6
p21 (RAC1) activated kinase 6
chr10_-_73655984 0.95 ENST00000394810.3
SYNPO2L
synaptopodin 2 like
chr3_+_54123452 0.91 ENST00000620722.4
ENST00000490478.5
CACNA2D3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr19_-_39833615 0.89 ENST00000593685.5
ENST00000600611.5
DYRK1B
dual specificity tyrosine phosphorylation regulated kinase 1B
chr11_-_19201976 0.84 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
CSRP3
cysteine and glycine rich protein 3
chr6_+_27957241 0.78 ENST00000244623.1
OR2B6
olfactory receptor family 2 subfamily B member 6
chr7_-_78489900 0.74 ENST00000636039.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_89063631 0.69 ENST00000455756.6
GRM5
glutamate metabotropic receptor 5
chr8_-_69833338 0.67 ENST00000524945.5
SLCO5A1
solute carrier organic anion transporter family member 5A1
chr12_+_15546344 0.65 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chr5_+_132673983 0.62 ENST00000622422.1
ENST00000231449.7
ENST00000350025.2
IL4
interleukin 4
chr4_+_44678412 0.61 ENST00000281543.6
GUF1
GTP binding elongation factor GUF1
chr12_+_25052634 0.54 ENST00000548766.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr12_+_25052732 0.54 ENST00000547044.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr17_-_36196748 0.52 ENST00000619989.1
CCL3L1
C-C motif chemokine ligand 3 like 1
chr15_+_68054308 0.51 ENST00000249636.11
PIAS1
protein inhibitor of activated STAT 1
chr3_+_36380477 0.49 ENST00000457375.6
ENST00000273183.8
ENST00000434649.1
STAC
SH3 and cysteine rich domain
chr10_+_116590956 0.48 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr5_-_132011580 0.47 ENST00000651250.1
ENST00000434099.6
ENST00000296869.9
ENST00000651356.1
ENST00000651883.2
ACSL6
acyl-CoA synthetase long chain family member 6
chr5_-_67196791 0.47 ENST00000256447.5
CD180
CD180 molecule
chr8_+_75539893 0.46 ENST00000674002.1
HNF4G
hepatocyte nuclear factor 4 gamma
chr10_-_95441015 0.43 ENST00000371241.5
ENST00000354106.7
ENST00000371239.5
ENST00000361941.7
ENST00000277982.9
ENST00000371245.7
SORBS1
sorbin and SH3 domain containing 1
chr15_+_40239420 0.33 ENST00000560346.5
PAK6
p21 (RAC1) activated kinase 6
chr9_-_95509241 0.28 ENST00000331920.11
PTCH1
patched 1
chr17_-_1486124 0.25 ENST00000575158.5
MYO1C
myosin IC
chr16_+_11965234 0.20 ENST00000562385.1
TNFRSF17
TNF receptor superfamily member 17
chr6_-_33192454 0.13 ENST00000395194.1
ENST00000341947.7
ENST00000374708.8
COL11A2
collagen type XI alpha 2 chain
chr10_+_116591010 0.11 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr8_+_11494367 0.09 ENST00000259089.9
ENST00000529894.1
BLK
BLK proto-oncogene, Src family tyrosine kinase
chr10_+_133527355 0.04 ENST00000252945.8
ENST00000421586.5
ENST00000418356.1
CYP2E1
cytochrome P450 family 2 subfamily E member 1
chr11_-_47378527 0.03 ENST00000378538.8
SPI1
Spi-1 proto-oncogene

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
3.5 17.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
2.4 19.4 GO:0061709 reticulophagy(GO:0061709)
2.1 6.3 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
2.1 35.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.6 14.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
1.5 4.6 GO:0010133 proline catabolic process to glutamate(GO:0010133)
1.3 3.8 GO:0071288 cellular response to mercury ion(GO:0071288)
1.2 9.7 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
1.1 7.9 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.1 8.5 GO:0001887 selenium compound metabolic process(GO:0001887)
1.1 5.3 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.9 12.7 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.7 4.3 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.7 31.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.6 3.7 GO:0038016 insulin receptor internalization(GO:0038016)
0.5 3.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.5 2.9 GO:0097338 response to clozapine(GO:0097338)
0.4 2.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.4 4.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.4 6.9 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.4 7.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.3 4.2 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.3 7.5 GO:0097503 sialylation(GO:0097503)
0.2 2.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 2.5 GO:0007512 adult heart development(GO:0007512)
0.2 2.0 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.2 2.6 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.2 2.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.2 3.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 7.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.2 0.7 GO:1902938 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.2 1.4 GO:0071313 cellular response to caffeine(GO:0071313)
0.2 4.9 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 0.6 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 1.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 8.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 21.2 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 12.8 GO:0061045 negative regulation of wound healing(GO:0061045)
0.1 2.5 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 2.6 GO:2000615 histone H3 deacetylation(GO:0070932) regulation of histone H3-K9 acetylation(GO:2000615)
0.1 16.4 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 0.8 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.1 1.2 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.1 0.5 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 1.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 3.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 3.1 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 7.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.5 GO:0006853 carnitine shuttle(GO:0006853)
0.1 0.3 GO:0010157 response to chlorate(GO:0010157)
0.1 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 1.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 2.6 GO:0015701 bicarbonate transport(GO:0015701)
0.0 2.2 GO:0007520 myoblast fusion(GO:0007520)
0.0 3.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.9 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 1.0 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 4.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 6.1 GO:0021915 neural tube development(GO:0021915)
0.0 0.9 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 1.6 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.3 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 17.7 GO:0031175 neuron projection development(GO:0031175)
0.0 12.4 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.0 GO:0010193 response to ozone(GO:0010193)
0.0 0.5 GO:0034605 cellular response to heat(GO:0034605)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 17.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
2.7 13.5 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.8 11.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.8 3.2 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.7 4.5 GO:0005927 muscle tendon junction(GO:0005927)
0.5 5.4 GO:0097512 cardiac myofibril(GO:0097512)
0.4 4.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.4 9.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.4 8.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.4 26.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 8.6 GO:0005861 troponin complex(GO:0005861)
0.4 5.3 GO:0030478 actin cap(GO:0030478)
0.3 19.4 GO:0005801 cis-Golgi network(GO:0005801)
0.3 69.0 GO:0030426 growth cone(GO:0030426)
0.3 3.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 1.4 GO:0030314 junctional membrane complex(GO:0030314)
0.2 3.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 6.1 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 3.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 2.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 6.1 GO:0000795 synaptonemal complex(GO:0000795)
0.1 11.7 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 14.6 GO:0030315 T-tubule(GO:0030315)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.1 5.8 GO:0014704 intercalated disc(GO:0014704)
0.1 1.5 GO:0032982 myosin filament(GO:0032982)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.0 GO:0005859 muscle myosin complex(GO:0005859)
0.0 2.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0005592 collagen type XI trimer(GO:0005592)
0.0 1.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 3.1 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 3.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 1.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.5 GO:0042383 sarcolemma(GO:0042383)
0.0 4.2 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 13.5 GO:0030348 syntaxin-3 binding(GO:0030348)
1.8 5.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.9 15.3 GO:0031432 titin binding(GO:0031432)
0.7 8.5 GO:0008430 selenium binding(GO:0008430)
0.6 8.6 GO:0031014 troponin T binding(GO:0031014)
0.6 17.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 9.7 GO:0003680 AT DNA binding(GO:0003680)
0.5 1.6 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.5 3.2 GO:0015168 intracellular cGMP activated cation channel activity(GO:0005223) glycerol transmembrane transporter activity(GO:0015168)
0.5 2.6 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.5 13.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.5 1.9 GO:0051373 FATZ binding(GO:0051373)
0.5 4.2 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.5 3.7 GO:0015235 cobalamin transporter activity(GO:0015235)
0.5 2.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.4 16.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.4 5.3 GO:0045159 myosin II binding(GO:0045159)
0.3 4.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.3 2.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.3 4.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 1.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.3 2.1 GO:0031433 telethonin binding(GO:0031433)
0.2 3.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 0.6 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.2 2.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 4.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 3.3 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 14.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 3.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.1 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 1.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 0.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.5 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.7 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 4.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 7.5 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 0.3 GO:0097108 hedgehog family protein binding(GO:0097108)
0.1 4.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 26.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 21.2 GO:0015631 tubulin binding(GO:0015631)
0.0 2.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 2.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 5.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.2 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.6 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 3.7 GO:0008201 heparin binding(GO:0008201)
0.0 1.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 9.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 8.6 GO:0004672 protein kinase activity(GO:0004672)
0.0 16.5 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 4.5 GO:0003779 actin binding(GO:0003779)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 13.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 4.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 32.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 13.5 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.2 11.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 7.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 4.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 10.3 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 16.5 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 0.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.9 PID RAS PATHWAY Regulation of Ras family activation
0.1 5.3 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 6.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 12.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID INSULIN PATHWAY Insulin Pathway
0.0 0.6 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 37.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.3 14.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.3 17.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 3.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 4.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 7.9 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 5.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 7.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 2.9 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 3.1 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 5.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 2.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.9 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 1.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 3.7 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.5 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 4.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction