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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MEIS2
Z-value: 10.83
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Transcription factors associated with MEIS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEIS2 | hg38_v1_chr15_-_37101205_37101326, hg38_v1_chr15_-_37100523_37100556 | -0.23 | 8.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 325.0 | GO:0031295 | T cell costimulation(GO:0031295) |
| 1.8 | 253.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.6 | 138.8 | GO:0002250 | adaptive immune response(GO:0002250) |
| 6.9 | 117.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.1 | 108.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 10.5 | 84.2 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 8.9 | 80.2 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.2 | 75.8 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 16.2 | 64.7 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 3.0 | 62.3 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.8 | 243.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 1.6 | 163.7 | GO:0030315 | T-tubule(GO:0030315) |
| 9.5 | 152.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 149.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 137.0 | GO:0045202 | synapse(GO:0045202) |
| 0.8 | 130.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 122.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 114.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 104.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.5 | 100.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 363.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.5 | 183.2 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 1.7 | 153.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 4.9 | 146.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 4.7 | 130.9 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 126.0 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.1 | 100.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 5.4 | 92.5 | GO:0031432 | titin binding(GO:0031432) |
| 6.5 | 91.4 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 21.1 | 84.2 | GO:0008832 | dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793) guanyl deoxyribonucleotide binding(GO:0032560) dGTP binding(GO:0032567) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 129.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.3 | 129.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 1.9 | 102.8 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.9 | 87.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 1.7 | 67.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 1.0 | 63.4 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 1.8 | 63.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 1.2 | 55.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 55.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 2.3 | 52.6 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 193.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 190.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.9 | 165.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.9 | 81.9 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 1.2 | 76.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 76.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.6 | 74.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.7 | 62.3 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.5 | 61.6 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 3.4 | 58.2 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |