Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MSX1

Z-value: 3.49

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Transcription factors associated with MSX1

Gene Symbol Gene ID Gene Info
MSX1
ENSG00000163132.8 MSX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX1hg38_v1_chr4_+_4859658_48596720.009.6e-01Click!

Activity profile of MSX1 motif

Sorted Z-values of MSX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_37598750 19.12 ENST00000379743.8
ENST00000379742.4
ENST00000379749.8
ENST00000379747.9
ENST00000541179.5
ENST00000541481.5
POSTN
periostin
chr1_+_244835616 12.30 ENST00000366528.3
ENST00000411948.7
COX20
cytochrome c oxidase assembly factor COX20
chr5_+_151025343 12.19 ENST00000521632.1
GPX3
glutathione peroxidase 3
chr11_+_6863057 11.17 ENST00000641461.1
OR10A2
olfactory receptor family 10 subfamily A member 2
chr6_-_32128191 9.80 ENST00000453203.2
ENST00000375203.8
ENST00000375201.8
ATF6B
activating transcription factor 6 beta
chr3_-_123620571 7.91 ENST00000583087.5
MYLK
myosin light chain kinase
chr3_-_123620496 7.81 ENST00000578202.1
MYLK
myosin light chain kinase
chr22_+_50738198 6.68 ENST00000216139.10
ENST00000529621.1
ACR
acrosin
chr2_-_135530561 6.62 ENST00000536680.5
ENST00000401392.5
ZRANB3
zinc finger RANBP2-type containing 3
chr19_-_9107475 6.46 ENST00000641081.1
OR7G2
olfactory receptor family 7 subfamily G member 2
chr18_-_5396265 6.13 ENST00000579951.2
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr6_-_52840843 5.44 ENST00000370989.6
GSTA5
glutathione S-transferase alpha 5
chr15_-_77420135 5.34 ENST00000560626.6
PEAK1
pseudopodium enriched atypical kinase 1
chr19_-_53254688 5.09 ENST00000594517.5
ENST00000601413.5
ENST00000594681.5
ZNF677
zinc finger protein 677
chr3_-_21751189 4.96 ENST00000281523.8
ZNF385D
zinc finger protein 385D
chr19_-_53254841 4.91 ENST00000601828.5
ENST00000599012.5
ENST00000598513.6
ENST00000598806.5
ZNF677
zinc finger protein 677
chr15_-_77420087 4.89 ENST00000564328.5
ENST00000682557.1
ENST00000558305.5
PEAK1
pseudopodium enriched atypical kinase 1
chr2_-_208163588 4.84 ENST00000304502.5
CRYGA
crystallin gamma A
chr13_-_52159559 4.57 ENST00000620675.4
ENST00000610828.5
NEK3
NIMA related kinase 3
chr14_+_22495890 4.54 ENST00000390494.1
TRAJ43
T cell receptor alpha joining 43
chr1_+_159015665 4.50 ENST00000567661.5
ENST00000474473.1
IFI16
interferon gamma inducible protein 16
chr19_-_53159004 4.28 ENST00000599096.1
ENST00000597183.5
ENST00000601804.5
ENST00000334197.12
ENST00000601469.2
ENST00000452676.6
ZNF347
zinc finger protein 347
chrX_+_1591590 4.28 ENST00000313871.9
ENST00000381261.8
AKAP17A
A-kinase anchoring protein 17A
chr6_+_118548289 4.23 ENST00000357525.6
PLN
phospholamban
chr4_+_118888829 4.19 ENST00000448416.6
ENST00000307142.9
ENST00000429713.7
SYNPO2
synaptopodin 2
chr12_+_9827472 4.06 ENST00000617793.4
ENST00000617889.5
ENST00000354855.7
ENST00000279545.7
KLRF1
killer cell lectin like receptor F1
chr12_-_42144823 4.04 ENST00000398675.8
GXYLT1
glucoside xylosyltransferase 1
chr9_+_130664594 4.03 ENST00000253008.3
ENST00000676323.1
PRDM12
PR/SET domain 12
chr14_-_74923234 3.92 ENST00000556776.1
ENST00000557413.6
ENST00000555647.5
RPS6KL1
ribosomal protein S6 kinase like 1
chr5_-_76623391 3.85 ENST00000296641.5
ENST00000504899.1
F2RL2
coagulation factor II thrombin receptor like 2
chr6_+_131573219 3.85 ENST00000356962.2
ENST00000368087.8
ENST00000673427.1
ENST00000640973.1
ARG1
arginase 1
chr1_+_111229692 3.79 ENST00000466741.5
ENST00000477185.6
CHI3L2
chitinase 3 like 2
chr10_+_17228215 3.69 ENST00000544301.7
VIM
vimentin
chr10_-_99620401 3.66 ENST00000370495.6
SLC25A28
solute carrier family 25 member 28
chr2_-_88627365 3.60 ENST00000303236.9
EIF2AK3
eukaryotic translation initiation factor 2 alpha kinase 3
chr5_+_83471764 3.54 ENST00000512590.6
ENST00000513960.5
ENST00000513984.5
VCAN
versican
chr1_-_150765785 3.44 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
CTSS
cathepsin S
chr13_-_52159844 3.36 ENST00000611833.4
NEK3
NIMA related kinase 3
chr2_+_32277883 3.32 ENST00000238831.9
YIPF4
Yip1 domain family member 4
chr1_-_160523204 3.31 ENST00000368055.1
ENST00000368057.8
ENST00000368059.7
SLAMF6
SLAM family member 6
chr11_+_101914997 3.31 ENST00000263468.13
CEP126
centrosomal protein 126
chr3_+_171843337 3.21 ENST00000334567.9
ENST00000619900.4
ENST00000450693.1
TMEM212
transmembrane protein 212
chr2_+_209579399 3.18 ENST00000360351.8
MAP2
microtubule associated protein 2
chr1_+_110873135 3.15 ENST00000271324.6
CD53
CD53 molecule
chrX_+_11293411 3.12 ENST00000348912.4
ENST00000380714.7
ENST00000380712.7
AMELX
amelogenin X-linked
chr8_+_30387064 3.11 ENST00000523115.5
ENST00000519647.5
RBPMS
RNA binding protein, mRNA processing factor
chr5_+_83471668 3.06 ENST00000342785.8
ENST00000343200.9
VCAN
versican
chr10_-_29634964 3.04 ENST00000375398.6
ENST00000355867.8
SVIL
supervillin
chr5_+_83471736 2.97 ENST00000265077.8
VCAN
versican
chr1_-_12831410 2.96 ENST00000619922.1
PRAMEF11
PRAME family member 11
chr11_-_129024157 2.95 ENST00000392657.7
ARHGAP32
Rho GTPase activating protein 32
chr16_-_66550112 2.91 ENST00000544898.6
ENST00000620035.5
ENST00000545043.6
TK2
thymidine kinase 2
chr16_-_66550142 2.77 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
TK2
thymidine kinase 2
chr7_+_99828010 2.75 ENST00000631161.2
ENST00000354829.7
ENST00000342499.8
ENST00000417625.5
ENST00000415413.5
ENST00000444905.5
ENST00000222382.5
ENST00000312017.9
CYP3A43
cytochrome P450 family 3 subfamily A member 43
chr16_-_66550005 2.73 ENST00000527284.6
TK2
thymidine kinase 2
chr3_-_94062906 2.73 ENST00000314636.3
ENST00000394221.3
DHFR2
dihydrofolate reductase 2
chr19_-_7747559 2.70 ENST00000394173.8
CD209
CD209 molecule
chr1_+_206635521 2.66 ENST00000367109.8
DYRK3
dual specificity tyrosine phosphorylation regulated kinase 3
chr1_+_158845798 2.61 ENST00000438394.1
MNDA
myeloid cell nuclear differentiation antigen
chr19_-_7747511 2.53 ENST00000593660.5
ENST00000204801.12
ENST00000315591.12
ENST00000354397.10
ENST00000394161.9
ENST00000593821.5
ENST00000602261.5
ENST00000601256.1
ENST00000601951.5
ENST00000315599.12
CD209
CD209 molecule
chr11_+_62270150 2.45 ENST00000525380.1
ENST00000227918.3
SCGB2A2
secretoglobin family 2A member 2
chr16_-_66550091 2.37 ENST00000564917.5
ENST00000677420.1
TK2
thymidine kinase 2
chr10_+_52128343 2.30 ENST00000672084.1
PRKG1
protein kinase cGMP-dependent 1
chr12_+_104986292 2.28 ENST00000552951.7
ENST00000637147.1
ENST00000622317.5
ENST00000280749.5
C12orf45
chromosome 12 open reading frame 45
chr18_+_63970029 2.23 ENST00000353706.6
ENST00000542677.5
ENST00000397985.7
ENST00000636430.1
ENST00000397988.7
ENST00000448851.5
SERPINB8
serpin family B member 8
chr6_+_96563117 2.22 ENST00000450218.6
FHL5
four and a half LIM domains 5
chr2_+_209579598 2.22 ENST00000445941.5
ENST00000673860.1
MAP2
microtubule associated protein 2
chr7_+_2596897 2.18 ENST00000423196.1
IQCE
IQ motif containing E
chr15_-_42208153 2.12 ENST00000348544.4
ENST00000318006.10
VPS39
VPS39 subunit of HOPS complex
chr7_-_32299287 2.11 ENST00000396193.5
PDE1C
phosphodiesterase 1C
chr2_+_209579429 2.10 ENST00000361559.8
MAP2
microtubule associated protein 2
chr21_+_42199686 2.06 ENST00000398457.6
ABCG1
ATP binding cassette subfamily G member 1
chr3_-_167407837 1.99 ENST00000455345.7
ZBBX
zinc finger B-box domain containing
chr16_-_66549839 1.98 ENST00000527800.6
ENST00000677555.1
ENST00000563369.6
TK2
thymidine kinase 2
chr1_-_152115443 1.97 ENST00000614923.1
TCHH
trichohyalin
chr6_+_6588082 1.95 ENST00000379953.6
LY86
lymphocyte antigen 86
chr8_-_71361860 1.92 ENST00000303824.11
ENST00000645451.1
EYA1
EYA transcriptional coactivator and phosphatase 1
chr8_+_28891304 1.91 ENST00000355231.9
HMBOX1
homeobox containing 1
chr2_-_218166951 1.88 ENST00000295683.3
CXCR1
C-X-C motif chemokine receptor 1
chr12_+_106357729 1.87 ENST00000228347.9
POLR3B
RNA polymerase III subunit B
chr11_-_102530738 1.85 ENST00000260227.5
MMP7
matrix metallopeptidase 7
chr1_-_167518521 1.83 ENST00000362089.10
CD247
CD247 molecule
chr8_+_2045037 1.65 ENST00000262113.9
MYOM2
myomesin 2
chr14_+_55129242 1.55 ENST00000254301.14
ENST00000554715.1
LGALS3
galectin 3
chr12_+_55931148 1.52 ENST00000549629.5
ENST00000555218.5
ENST00000331886.10
DGKA
diacylglycerol kinase alpha
chr3_+_108589667 1.44 ENST00000361582.8
ENST00000486815.5
DZIP3
DAZ interacting zinc finger protein 3
chr18_-_3874270 1.43 ENST00000400149.7
ENST00000400155.5
ENST00000400150.7
DLGAP1
DLG associated protein 1
chrY_-_6872608 1.33 ENST00000383036.1
AMELY
amelogenin Y-linked
chr7_+_2559422 1.32 ENST00000325979.11
ENST00000423395.5
IQCE
IQ motif containing E
chr1_-_167518583 1.31 ENST00000392122.3
CD247
CD247 molecule
chr13_+_48976597 1.28 ENST00000541916.5
FNDC3A
fibronectin type III domain containing 3A
chr11_-_102625332 1.25 ENST00000260228.3
MMP20
matrix metallopeptidase 20
chr9_-_92482350 1.22 ENST00000375543.2
ASPN
asporin
chr19_-_20039205 1.20 ENST00000358523.9
ENST00000397162.5
ENST00000601100.5
ZNF682
zinc finger protein 682
chr4_-_99219230 1.14 ENST00000394897.5
ENST00000508558.1
ENST00000394899.6
ADH6
alcohol dehydrogenase 6 (class V)
chr4_+_70242583 1.10 ENST00000304954.3
CSN3
casein kappa
chr2_-_77522347 1.09 ENST00000409093.1
ENST00000409884.6
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr6_+_28124596 1.02 ENST00000340487.5
ZSCAN16
zinc finger and SCAN domain containing 16
chr11_-_55936400 0.83 ENST00000301532.3
OR5I1
olfactory receptor family 5 subfamily I member 1
chr22_+_41301514 0.83 ENST00000352645.5
ZC3H7B
zinc finger CCCH-type containing 7B
chr2_+_147845020 0.82 ENST00000241416.12
ACVR2A
activin A receptor type 2A
chr4_-_185775271 0.82 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr1_-_158426237 0.81 ENST00000641042.1
OR10K2
olfactory receptor family 10 subfamily K member 2
chr9_+_76459152 0.78 ENST00000444201.6
ENST00000376730.5
GCNT1
glucosaminyl (N-acetyl) transferase 1
chr12_+_9827517 0.78 ENST00000537723.5
KLRF1
killer cell lectin like receptor F1
chr6_+_135851681 0.75 ENST00000308191.11
PDE7B
phosphodiesterase 7B
chr6_+_29170907 0.66 ENST00000641417.1
OR2J2
olfactory receptor family 2 subfamily J member 2
chr8_+_2045058 0.63 ENST00000523438.1
MYOM2
myomesin 2
chr8_-_98045507 0.58 ENST00000521291.5
RPL30
ribosomal protein L30
chr8_-_98045532 0.57 ENST00000396070.6
ENST00000287038.8
ENST00000523172.5
RPL30
ribosomal protein L30
chr11_+_45804038 0.55 ENST00000442528.2
ENST00000526817.1
SLC35C1
solute carrier family 35 member C1
chr9_+_87497222 0.54 ENST00000358077.9
DAPK1
death associated protein kinase 1
chr6_-_32816910 0.47 ENST00000447394.1
ENST00000438763.7
HLA-DOB
major histocompatibility complex, class II, DO beta
chr8_+_24384275 0.46 ENST00000256412.8
ADAMDEC1
ADAM like decysin 1
chr6_-_109483208 0.46 ENST00000230122.4
ZBTB24
zinc finger and BTB domain containing 24
chr3_-_94062881 0.40 ENST00000619045.1
DHFR2
dihydrofolate reductase 2
chrX_-_11265975 0.37 ENST00000303025.10
ENST00000657361.1
ARHGAP6
Rho GTPase activating protein 6
chr5_-_147782518 0.36 ENST00000507386.5
JAKMIP2
janus kinase and microtubule interacting protein 2
chr1_-_149936324 0.31 ENST00000369140.7
MTMR11
myotubularin related protein 11
chr7_-_20217342 0.24 ENST00000400331.10
ENST00000332878.8
MACC1
MET transcriptional regulator MACC1
chr2_-_166149204 0.19 ENST00000635750.1
SCN1A
sodium voltage-gated channel alpha subunit 1
chr6_+_29100609 0.18 ENST00000377171.3
OR2J1
olfactory receptor family 2 subfamily J member 1
chr8_+_24384455 0.16 ENST00000522298.1
ADAMDEC1
ADAM like decysin 1
chr6_+_29173303 0.14 ENST00000377167.3
OR2J2
olfactory receptor family 2 subfamily J member 2
chr1_+_210328244 0.06 ENST00000541565.5
ENST00000413764.6
HHAT
hedgehog acyltransferase
chr19_-_49036885 0.01 ENST00000604577.1
ENST00000591656.1
ENST00000301407.8
ENST00000601167.1
ENSG00000267335.2
CGB1
novel protein
chorionic gonadotropin subunit beta 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
3.8 19.1 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
2.6 15.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
2.2 6.6 GO:0036292 DNA rewinding(GO:0036292)
2.1 12.8 GO:0046092 deoxycytidine metabolic process(GO:0046092)
1.4 4.2 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) negative regulation of calcium-transporting ATPase activity(GO:1901895)
1.3 5.2 GO:0046968 peptide antigen transport(GO:0046968)
1.2 3.7 GO:0048250 mitochondrial iron ion transport(GO:0048250)
1.1 3.4 GO:0034769 basement membrane disassembly(GO:0034769)
1.1 6.7 GO:0007341 penetration of zona pellucida(GO:0007341)
1.0 4.0 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
1.0 3.8 GO:1902023 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.9 12.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.9 3.6 GO:1990737 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.8 3.1 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.8 9.8 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.7 2.1 GO:0009720 detection of hormone stimulus(GO:0009720)
0.7 6.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.6 1.9 GO:0098758 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.6 7.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.5 3.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.5 1.5 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
0.4 2.7 GO:0035617 stress granule disassembly(GO:0035617)
0.4 2.1 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.4 9.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.3 3.8 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.3 2.5 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.3 3.7 GO:0070307 lens fiber cell development(GO:0070307)
0.3 1.2 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
0.3 2.3 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.3 2.3 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 2.0 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 1.9 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 3.3 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.2 20.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 3.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.2 0.6 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.2 3.9 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.2 0.5 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 2.2 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 0.8 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 1.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 3.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 2.6 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.1 1.1 GO:0006069 ethanol oxidation(GO:0006069)
0.1 1.3 GO:0034505 tooth mineralization(GO:0034505)
0.1 4.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 3.1 GO:0070207 protein homotrimerization(GO:0070207)
0.1 0.8 GO:0060352 cell adhesion molecule production(GO:0060352)
0.1 10.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 4.0 GO:0016266 O-glycan processing(GO:0016266)
0.1 1.5 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 1.6 GO:0044849 estrous cycle(GO:0044849)
0.1 5.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 4.2 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 4.8 GO:0002088 lens development in camera-type eye(GO:0002088)
0.1 7.5 GO:0021954 central nervous system neuron development(GO:0021954)
0.1 3.3 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.1 1.3 GO:0060009 Sertoli cell development(GO:0060009)
0.0 1.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.5 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.4 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 1.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.2 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 3.0 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0043159 acrosomal matrix(GO:0043159)
0.9 7.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.5 3.4 GO:0036021 endolysosome lumen(GO:0036021)
0.3 3.0 GO:0036449 microtubule minus-end(GO:0036449)
0.3 6.1 GO:0033270 paranode region of axon(GO:0033270)
0.3 1.4 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.3 3.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 15.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 19.1 GO:0031594 neuromuscular junction(GO:0031594)
0.2 4.2 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.2 2.1 GO:0030897 HOPS complex(GO:0030897)
0.1 0.8 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 6.6 GO:0043596 nuclear replication fork(GO:0043596)
0.1 3.1 GO:0005685 U1 snRNP(GO:0005685)
0.1 4.7 GO:0001772 immunological synapse(GO:0001772)
0.1 2.3 GO:0032982 myosin filament(GO:0032982)
0.1 3.3 GO:0097546 ciliary base(GO:0097546)
0.1 1.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 9.6 GO:0005796 Golgi lumen(GO:0005796)
0.1 11.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 1.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 6.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 5.2 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.0 4.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.0 GO:0001533 cornified envelope(GO:0001533)
0.0 2.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 5.1 GO:0005840 ribosome(GO:0005840)
0.0 8.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.7 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.0 GO:0001650 fibrillar center(GO:0001650)
0.0 20.7 GO:0044429 mitochondrial part(GO:0044429)
0.0 2.0 GO:0055037 recycling endosome(GO:0055037)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 7.9 GO:0030424 axon(GO:0030424)
0.0 19.8 GO:0005615 extracellular space(GO:0005615)
0.0 4.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.5 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 15.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.2 6.7 GO:0004040 amidase activity(GO:0004040) fucose binding(GO:0042806)
1.8 12.8 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
1.1 4.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
1.0 3.1 GO:0046848 hydroxyapatite binding(GO:0046848)
1.0 12.2 GO:0008430 selenium binding(GO:0008430)
0.8 3.1 GO:0004146 dihydrofolate reductase activity(GO:0004146)
0.7 3.7 GO:1990254 keratin filament binding(GO:1990254)
0.7 3.6 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.7 4.0 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.6 3.9 GO:0015057 thrombin receptor activity(GO:0015057)
0.6 1.9 GO:0019959 interleukin-8 binding(GO:0019959)
0.6 3.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.6 6.6 GO:0036310 annealing helicase activity(GO:0036310)
0.5 2.1 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.5 9.8 GO:0035497 cAMP response element binding(GO:0035497)
0.5 2.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.4 4.0 GO:1990226 histone methyltransferase binding(GO:1990226)
0.4 5.2 GO:0046790 virion binding(GO:0046790)
0.3 3.8 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.3 4.8 GO:0032393 MHC class I receptor activity(GO:0032393)
0.3 7.5 GO:0002162 dystroglycan binding(GO:0002162)
0.3 3.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.3 6.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 0.8 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.3 3.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 9.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.2 1.3 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.2 20.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 1.5 GO:0019863 IgE binding(GO:0019863)
0.2 0.6 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.2 1.9 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.2 4.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 1.2 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 1.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 1.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 2.8 GO:0070330 aromatase activity(GO:0070330)
0.1 3.4 GO:0001968 fibronectin binding(GO:0001968)
0.1 5.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 10.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.8 GO:0098821 BMP receptor activity(GO:0098821)
0.1 17.9 GO:0008201 heparin binding(GO:0008201)
0.1 1.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 5.0 GO:0002039 p53 binding(GO:0002039)
0.0 0.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 3.1 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 4.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 2.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.7 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.0 GO:0051015 actin filament binding(GO:0051015)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.0 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.3 9.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 15.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 23.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.5 PID LKB1 PATHWAY LKB1 signaling events
0.1 4.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 1.9 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 3.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 9.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 3.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 4.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 12.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 9.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 3.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 15.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 19.3 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 4.0 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 5.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 3.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 3.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.9 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 2.1 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.9 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.5 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.5 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.1 2.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 1.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.0 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades