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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MSX2

Z-value: 3.54

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Transcription factors associated with MSX2

Gene Symbol Gene ID Gene Info
MSX2
ENSG00000120149.9 MSX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX2hg38_v1_chr5_+_174724549_1747246070.045.8e-01Click!

Activity profile of MSX2 motif

Sorted Z-values of MSX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_197146688 11.68 ENST00000294732.11
ASPM
assembly factor for spindle microtubules
chr20_-_56392131 10.71 ENST00000422322.5
ENST00000371356.6
ENST00000451915.1
ENST00000347343.6
ENST00000395911.5
ENST00000395915.8
ENST00000395907.5
ENST00000441357.5
ENST00000456249.5
ENST00000420474.5
ENST00000395914.5
ENST00000312783.10
ENST00000395913.7
AURKA
aurora kinase A
chr1_-_197146620 9.83 ENST00000367409.9
ENST00000680265.1
ASPM
assembly factor for spindle microtubules
chr10_+_123154768 8.98 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr12_+_28257195 8.75 ENST00000381259.5
CCDC91
coiled-coil domain containing 91
chr9_+_78297143 8.54 ENST00000347159.6
PSAT1
phosphoserine aminotransferase 1
chr5_+_96662366 8.43 ENST00000675179.1
ENST00000421689.6
ENST00000674984.1
ENST00000512620.5
CAST
calpastatin
chr9_+_78297117 8.27 ENST00000376588.4
PSAT1
phosphoserine aminotransferase 1
chr5_+_96662214 8.23 ENST00000395812.6
CAST
calpastatin
chrX_+_115593570 8.00 ENST00000539310.5
PLS3
plastin 3
chr5_+_163437569 7.87 ENST00000512163.5
ENST00000393929.5
ENST00000510097.5
ENST00000340828.7
ENST00000511490.4
ENST00000510664.5
CCNG1
cyclin G1
chr5_+_96662314 7.64 ENST00000674702.1
CAST
calpastatin
chr17_-_40417873 7.07 ENST00000423485.6
TOP2A
DNA topoisomerase II alpha
chr16_-_46621345 6.84 ENST00000303383.8
SHCBP1
SHC binding and spindle associated 1
chr1_-_151992571 6.47 ENST00000368809.1
S100A10
S100 calcium binding protein A10
chr5_+_96662046 6.40 ENST00000338252.7
ENST00000508830.5
CAST
calpastatin
chr10_+_123154414 5.19 ENST00000368858.9
BUB3
BUB3 mitotic checkpoint protein
chr5_-_31532039 5.05 ENST00000511367.6
ENST00000344624.8
ENST00000513349.5
DROSHA
drosha ribonuclease III
chrX_+_77899440 4.71 ENST00000373335.4
ENST00000475465.1
ENST00000650309.2
ENST00000647835.1
COX7B
cytochrome c oxidase subunit 7B
chr13_+_48037692 4.42 ENST00000258662.3
NUDT15
nudix hydrolase 15
chr6_-_111606260 4.41 ENST00000340026.10
TRAF3IP2
TRAF3 interacting protein 2
chr12_+_53268289 4.33 ENST00000257934.9
ESPL1
extra spindle pole bodies like 1, separase
chr5_+_31532277 4.28 ENST00000507818.6
ENST00000325366.14
C5orf22
chromosome 5 open reading frame 22
chr11_+_17276708 4.25 ENST00000531172.5
ENST00000529010.6
ENST00000533738.6
ENST00000323688.10
NUCB2
nucleobindin 2
chr6_+_30720335 4.04 ENST00000327892.13
TUBB
tubulin beta class I
chr10_+_123154364 3.96 ENST00000368859.6
ENST00000368865.9
BUB3
BUB3 mitotic checkpoint protein
chr12_-_119877270 3.85 ENST00000261833.11
ENST00000612548.4
CIT
citron rho-interacting serine/threonine kinase
chr11_+_108665045 3.82 ENST00000322536.8
DDX10
DEAD-box helicase 10
chr6_+_106360668 3.69 ENST00000633556.3
CRYBG1
crystallin beta-gamma domain containing 1
chr15_-_37101205 3.64 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
MEIS2
Meis homeobox 2
chr14_-_23035223 3.56 ENST00000425762.2
PSMB5
proteasome 20S subunit beta 5
chr19_+_17267376 3.37 ENST00000447614.6
ENST00000359435.8
ENST00000599474.5
ENST00000599057.5
ENST00000598188.6
ENST00000601043.5
BABAM1
BRISC and BRCA1 A complex member 1
chr11_-_72112750 3.32 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
ANAPC15
anaphase promoting complex subunit 15
chr3_-_142029108 3.29 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr16_+_69424634 3.24 ENST00000515314.6
ENST00000561792.6
ENST00000568237.1
CYB5B
cytochrome b5 type B
chr19_+_17267469 3.23 ENST00000596335.5
ENST00000601436.5
ENST00000595632.5
BABAM1
BRISC and BRCA1 A complex member 1
chr11_-_72112068 3.20 ENST00000537644.5
ENST00000538919.5
ENST00000539395.1
ENST00000542531.5
ANAPC15
anaphase promoting complex subunit 15
chr12_-_119877300 3.11 ENST00000392521.7
CIT
citron rho-interacting serine/threonine kinase
chr7_+_131110087 2.98 ENST00000421797.6
MKLN1
muskelin 1
chr17_-_50707855 2.98 ENST00000285243.7
ANKRD40
ankyrin repeat domain 40
chr11_-_72112669 2.93 ENST00000545944.5
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr1_-_93585071 2.72 ENST00000539242.5
BCAR3
BCAR3 adaptor protein, NSP family member
chr7_+_134646845 2.50 ENST00000344924.8
BPGM
bisphosphoglycerate mutase
chr3_-_11643871 2.49 ENST00000430365.7
VGLL4
vestigial like family member 4
chr12_-_8949628 2.41 ENST00000000412.8
ENST00000543845.1
ENST00000544245.1
ENST00000536844.5
M6PR
mannose-6-phosphate receptor, cation dependent
chr6_-_31862809 2.35 ENST00000375631.5
NEU1
neuraminidase 1
chr7_+_134646798 2.29 ENST00000418040.5
ENST00000393132.2
BPGM
bisphosphoglycerate mutase
chr22_-_30564889 2.27 ENST00000401975.5
ENST00000428682.5
ENST00000423299.5
GAL3ST1
galactose-3-O-sulfotransferase 1
chr17_-_31901658 2.26 ENST00000261708.9
UTP6
UTP6 small subunit processome component
chr6_+_159761991 2.13 ENST00000367048.5
ACAT2
acetyl-CoA acetyltransferase 2
chr7_-_100119323 1.99 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chr6_-_111605859 1.57 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr12_-_10802627 1.54 ENST00000240687.2
TAS2R7
taste 2 receptor member 7
chr11_-_69819410 1.54 ENST00000334134.4
FGF3
fibroblast growth factor 3
chr1_-_68232514 1.51 ENST00000262348.9
ENST00000370973.2
ENST00000370971.1
WLS
Wnt ligand secretion mediator
chr12_+_54325120 1.48 ENST00000549043.5
ENST00000552218.5
ENST00000262061.7
ENST00000553231.5
ENST00000552362.5
ENST00000455864.6
ENST00000549116.5
ENST00000551779.5
COPZ1
COPI coat complex subunit zeta 1
chr7_-_100119840 1.45 ENST00000437822.6
TAF6
TATA-box binding protein associated factor 6
chr3_-_120682215 1.40 ENST00000283871.10
HGD
homogentisate 1,2-dioxygenase
chr7_+_91940851 1.35 ENST00000679821.1
ENST00000681722.1
ENST00000680181.1
ENST00000356239.8
ENST00000679521.1
ENST00000680952.1
ENST00000681412.1
ENST00000680766.1
AKAP9
A-kinase anchoring protein 9
chr16_+_69311339 1.29 ENST00000254950.13
VPS4A
vacuolar protein sorting 4 homolog A
chr7_+_91940836 1.29 ENST00000680534.1
ENST00000680513.1
ENST00000680072.1
AKAP9
A-kinase anchoring protein 9
chr1_-_68232539 1.22 ENST00000370976.7
ENST00000354777.6
WLS
Wnt ligand secretion mediator
chr12_-_56645955 1.15 ENST00000552959.5
ENST00000551020.5
ENST00000553007.2
ENST00000262030.8
ATP5F1B
ATP synthase F1 subunit beta
chr19_-_19138442 0.96 ENST00000587583.6
ENST00000450333.6
ENST00000587096.5
ENST00000162044.14
ENST00000592369.1
ENST00000587915.1
TMEM161A
transmembrane protein 161A
chr2_-_55419565 0.94 ENST00000647341.1
ENST00000647401.1
ENST00000336838.10
ENST00000621814.4
ENST00000644033.1
ENST00000645477.1
ENST00000647517.1
CCDC88A
coiled-coil domain containing 88A
chr19_-_45584769 0.87 ENST00000263275.5
OPA3
outer mitochondrial membrane lipid metabolism regulator OPA3
chr2_-_55419821 0.82 ENST00000644630.1
ENST00000471947.2
ENST00000436346.7
ENST00000642200.1
ENST00000413716.7
ENST00000263630.13
ENST00000645072.1
CCDC88A
coiled-coil domain containing 88A
chr3_-_165078480 0.74 ENST00000264382.8
SI
sucrase-isomaltase
chr19_+_15082211 0.73 ENST00000641398.1
OR1I1
olfactory receptor family 1 subfamily I member 1
chr6_+_25652272 0.71 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr5_-_149379286 0.67 ENST00000261796.4
IL17B
interleukin 17B
chr1_-_21050952 0.66 ENST00000264211.12
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chr11_-_13495984 0.61 ENST00000282091.6
PTH
parathyroid hormone
chr9_-_134068012 0.61 ENST00000303407.12
BRD3
bromodomain containing 3
chr7_-_25228485 0.60 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr1_-_47314089 0.57 ENST00000360380.7
ENST00000371877.8
ENST00000447475.7
STIL
STIL centriolar assembly protein
chr14_-_50561119 0.48 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr5_+_141177790 0.44 ENST00000239444.4
ENST00000623995.1
PCDHB8
ENSG00000279472.1
protocadherin beta 8
novel transcript
chr19_-_45782479 0.44 ENST00000447742.6
ENST00000354227.9
ENST00000291270.9
ENST00000683086.1
ENST00000343373.10
DMPK
DM1 protein kinase
chr9_+_34646654 0.42 ENST00000378842.8
GALT
galactose-1-phosphate uridylyltransferase
chr8_+_2045058 0.42 ENST00000523438.1
MYOM2
myomesin 2
chr3_-_48635426 0.37 ENST00000455886.6
ENST00000431739.5
ENST00000426599.1
ENST00000383733.7
ENST00000395550.7
ENST00000420764.6
ENST00000337000.12
SLC26A6
solute carrier family 26 member 6
chr14_-_52069228 0.32 ENST00000617139.4
NID2
nidogen 2
chr1_-_151459169 0.19 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
POGZ
pogo transposable element derived with ZNF domain
chr9_+_34646589 0.15 ENST00000450095.6
GALT
galactose-1-phosphate uridylyltransferase
chr17_-_10469558 0.08 ENST00000255381.2
MYH4
myosin heavy chain 4
chr14_-_52069039 0.06 ENST00000216286.10
NID2
nidogen 2
chr1_+_175067831 0.02 ENST00000239462.9
TNN
tenascin N

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.2 21.5 GO:0009786 regulation of asymmetric cell division(GO:0009786)
5.6 16.8 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
3.6 10.7 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
1.3 30.7 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.9 2.7 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.8 4.8 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.8 7.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.7 8.8 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.7 4.3 GO:0045842 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.7 27.6 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.6 4.4 GO:0006203 dGTP catabolic process(GO:0006203)
0.4 1.3 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.4 5.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.3 8.0 GO:0051639 actin filament network formation(GO:0051639)
0.3 6.5 GO:0001765 membrane raft assembly(GO:0001765)
0.3 6.0 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.3 2.3 GO:0006689 ganglioside catabolic process(GO:0006689)
0.3 2.6 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.3 1.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.3 2.3 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 4.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 2.4 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.2 0.6 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.2 1.4 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 6.6 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 7.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.4 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.6 GO:0033504 floor plate development(GO:0033504)
0.1 0.7 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 3.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 2.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 7.9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 6.8 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.1 1.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 4.0 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 2.3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.6 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 3.6 GO:0008542 visual learning(GO:0008542)
0.0 1.5 GO:0055026 negative regulation of cardiac muscle tissue development(GO:0055026)
0.0 0.7 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 3.4 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 3.6 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
0.0 1.5 GO:1901998 toxin transport(GO:1901998)
0.0 2.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 1.0 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 1.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.4 GO:0071711 basement membrane organization(GO:0071711)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 18.1 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
3.6 32.2 GO:0072687 meiotic spindle(GO:0072687)
0.7 6.6 GO:0070552 BRISC complex(GO:0070552)
0.7 2.6 GO:0044307 dendritic branch(GO:0044307)
0.5 2.3 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.3 9.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 4.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 3.6 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 4.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 3.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 5.1 GO:1902555 endoribonuclease complex(GO:1902555)
0.1 1.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.4 GO:0030904 retromer complex(GO:0030904)
0.1 9.3 GO:0005814 centriole(GO:0005814)
0.1 2.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 7.0 GO:0031985 Golgi cisterna(GO:0031985)
0.0 8.0 GO:0005884 actin filament(GO:0005884)
0.0 6.8 GO:0030496 midbody(GO:0030496)
0.0 0.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 7.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 4.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.9 GO:0072686 mitotic spindle(GO:0072686)
0.0 6.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 2.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 3.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.3 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 30.7 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
2.4 7.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.5 4.4 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
1.2 10.7 GO:0035174 histone serine kinase activity(GO:0035174)
1.0 4.8 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.8 5.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.8 2.3 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.5 2.1 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.4 10.5 GO:0008483 transaminase activity(GO:0008483)
0.3 2.3 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.2 4.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 4.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.7 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.1 1.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 2.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 3.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 18.1 GO:0043130 ubiquitin binding(GO:0043130)
0.1 6.8 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.4 GO:0005537 mannose binding(GO:0005537)
0.1 0.4 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.1 1.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.7 GO:0043422 protein kinase B binding(GO:0043422)
0.1 2.3 GO:0030515 snoRNA binding(GO:0030515)
0.1 5.7 GO:0097110 scaffold protein binding(GO:0097110)
0.1 0.6 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 15.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 7.9 GO:0051015 actin filament binding(GO:0051015)
0.0 4.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 6.1 GO:0044325 ion channel binding(GO:0044325)
0.0 0.7 GO:0000339 RNA cap binding(GO:0000339)
0.0 2.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 2.1 GO:0020037 heme binding(GO:0020037)
0.0 6.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.7 PID AURORA A PATHWAY Aurora A signaling
0.1 7.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 18.1 PID P73PATHWAY p73 transcription factor network
0.1 7.9 PID P53 REGULATION PATHWAY p53 pathway
0.1 7.0 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 3.3 PID E2F PATHWAY E2F transcription factor network
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 8.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 18.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.6 16.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 14.3 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 5.1 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 1.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 3.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 4.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.6 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.5 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.7 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 2.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 4.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 4.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes