Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NANOG

Z-value: 0.57

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Transcription factors associated with NANOG

Gene Symbol Gene ID Gene Info
NANOG
ENSG00000111704.11 NANOG

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NANOGhg38_v1_chr12_+_7789393_7789417-0.027.5e-01Click!

Activity profile of NANOG motif

Sorted Z-values of NANOG motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NANOG

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_-_38852321 4.79 ENST00000600873.5
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr5_+_157266079 4.11 ENST00000616178.4
ENST00000522463.5
ENST00000435847.6
ENST00000620254.5
ENST00000521420.5
ENST00000617629.4
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr11_-_67437670 3.33 ENST00000326294.4
PTPRCAP
protein tyrosine phosphatase receptor type C associated protein
chrX_-_119693150 3.12 ENST00000394610.7
SEPTIN6
septin 6
chr10_+_10798570 3.09 ENST00000638035.1
ENST00000636488.1
CELF2
CUGBP Elav-like family member 2
chr17_-_36090133 2.59 ENST00000613922.2
CCL3
C-C motif chemokine ligand 3
chrX_-_119693370 2.58 ENST00000360156.11
ENST00000354228.8
ENST00000489216.5
ENST00000354416.7
ENST00000343984.5
SEPTIN6
septin 6
chr12_-_121793668 2.43 ENST00000267205.7
RHOF
ras homolog family member F, filopodia associated
chr12_-_122703346 2.42 ENST00000328880.6
HCAR2
hydroxycarboxylic acid receptor 2
chr19_-_42302576 2.31 ENST00000262890.8
PAFAH1B3
platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr19_-_42302766 2.27 ENST00000595530.5
ENST00000538771.5
ENST00000601865.5
PAFAH1B3
platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr10_+_128047559 2.16 ENST00000306042.9
PTPRE
protein tyrosine phosphatase receptor type E
chr19_-_42302292 2.14 ENST00000594989.5
PAFAH1B3
platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr19_-_42302690 2.13 ENST00000596265.5
PAFAH1B3
platelet activating factor acetylhydrolase 1b catalytic subunit 3
chr11_+_126304041 2.10 ENST00000263579.5
DCPS
decapping enzyme, scavenger
chr4_+_165327659 2.05 ENST00000507013.5
ENST00000261507.11
ENST00000393766.6
ENST00000504317.1
MSMO1
methylsterol monooxygenase 1
chr11_-_72793592 1.99 ENST00000536377.5
ENST00000359373.9
STARD10
ARAP1
StAR related lipid transfer domain containing 10
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr12_-_122716790 1.86 ENST00000528880.3
HCAR3
hydroxycarboxylic acid receptor 3
chr19_+_926001 1.80 ENST00000263620.8
ARID3A
AT-rich interaction domain 3A
chr19_-_13102848 1.78 ENST00000264824.5
LYL1
LYL1 basic helix-loop-helix family member
chr1_+_44405247 1.71 ENST00000361799.7
ENST00000372247.6
RNF220
ring finger protein 220
chr14_+_23322019 1.60 ENST00000557702.5
PABPN1
poly(A) binding protein nuclear 1
chr15_+_78540729 1.55 ENST00000559365.5
ENST00000558341.5
ENST00000559437.5
PSMA4
proteasome 20S subunit alpha 4
chr8_-_90082871 1.54 ENST00000265431.7
CALB1
calbindin 1
chr1_+_44405164 1.53 ENST00000355387.6
RNF220
ring finger protein 220
chr15_+_78540405 1.50 ENST00000560217.5
ENST00000559082.5
ENST00000559948.5
ENST00000413382.6
ENST00000559146.5
ENST00000044462.12
ENST00000558281.5
PSMA4
proteasome 20S subunit alpha 4
chr14_+_23321543 1.50 ENST00000556821.5
PABPN1
poly(A) binding protein nuclear 1
chr6_+_34236865 1.40 ENST00000674029.1
ENST00000447654.5
ENST00000347617.10
ENST00000401473.7
ENST00000311487.9
HMGA1
high mobility group AT-hook 1
chr1_+_159302321 1.36 ENST00000368114.1
FCER1A
Fc fragment of IgE receptor Ia
chr6_-_32192630 1.32 ENST00000375040.8
GPSM3
G protein signaling modulator 3
chr1_-_28193873 1.30 ENST00000305392.3
ENST00000539896.1
PTAFR
platelet activating factor receptor
chr9_+_69205141 1.26 ENST00000649134.1
ENST00000539225.2
ENST00000650084.1
ENST00000648402.1
TJP2
tight junction protein 2
chr14_-_60165363 1.24 ENST00000557185.6
DHRS7
dehydrogenase/reductase 7
chr1_+_161581339 1.19 ENST00000543859.5
ENST00000611236.1
FCGR2C
Fc fragment of IgG receptor IIc (gene/pseudogene)
chr16_-_11256192 1.19 ENST00000644787.1
ENST00000332029.4
SOCS1
suppressor of cytokine signaling 1
chr1_+_161663147 1.18 ENST00000236937.13
ENST00000367961.8
ENST00000358671.9
FCGR2B
Fc fragment of IgG receptor IIb
chr19_-_39435910 1.11 ENST00000599539.5
RPS16
ribosomal protein S16
chr6_-_161274010 1.11 ENST00000366911.9
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr6_+_31665234 1.11 ENST00000677536.1
ENST00000375885.8
CSNK2B
casein kinase 2 beta
chr6_+_31572279 1.09 ENST00000418386.3
LTA
lymphotoxin alpha
chr1_-_202159977 1.05 ENST00000367279.8
PTPN7
protein tyrosine phosphatase non-receptor type 7
chr6_-_161274042 1.04 ENST00000320285.9
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr19_-_39435627 1.00 ENST00000599705.1
RPS16
ribosomal protein S16
chr6_+_30717433 0.98 ENST00000681435.1
TUBB
tubulin beta class I
chr22_-_41688859 0.97 ENST00000401959.6
ENST00000648674.1
SNU13
small nuclear ribonucleoprotein 13
chr19_-_39435936 0.97 ENST00000339471.8
ENST00000601655.5
ENST00000251453.8
RPS16
ribosomal protein S16
chr7_-_78771265 0.95 ENST00000630991.2
ENST00000629359.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_+_31571957 0.93 ENST00000454783.5
LTA
lymphotoxin alpha
chr10_-_27154226 0.92 ENST00000427324.5
ENST00000375972.7
ENST00000326799.7
YME1L1
YME1 like 1 ATPase
chr2_+_169733811 0.92 ENST00000392647.7
KLHL23
kelch like family member 23
chr4_+_39698109 0.89 ENST00000510934.5
ENST00000261427.10
UBE2K
ubiquitin conjugating enzyme E2 K
chr22_+_37051731 0.86 ENST00000610767.4
ENST00000402077.7
ENST00000403888.7
KCTD17
potassium channel tetramerization domain containing 17
chr22_+_37051787 0.86 ENST00000456470.1
KCTD17
potassium channel tetramerization domain containing 17
chr6_+_30557287 0.85 ENST00000376560.8
PRR3
proline rich 3
chr5_+_42548043 0.81 ENST00000618088.4
ENST00000612382.4
GHR
growth hormone receptor
chr10_+_96130027 0.81 ENST00000478086.5
ENST00000624776.3
ZNF518A
zinc finger protein 518A
chr2_-_213151590 0.80 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKZF2
IKAROS family zinc finger 2
chr6_+_30557274 0.78 ENST00000376557.3
PRR3
proline rich 3
chr19_-_49867542 0.77 ENST00000600910.5
ENST00000322344.8
ENST00000600573.5
ENST00000596726.3
ENST00000638016.1
PNKP
polynucleotide kinase 3'-phosphatase
chr10_+_96129707 0.75 ENST00000316045.9
ZNF518A
zinc finger protein 518A
chr11_+_26332117 0.74 ENST00000531646.1
ENST00000256737.8
ANO3
anoctamin 3
chr15_+_77420880 0.74 ENST00000336216.9
ENST00000558176.1
HMG20A
high mobility group 20A
chr3_+_122055355 0.73 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86
CD86 molecule
chr2_-_174248570 0.73 ENST00000344357.9
OLA1
Obg like ATPase 1
chr17_+_77376083 0.72 ENST00000427674.6
SEPTIN9
septin 9
chr17_-_45051517 0.72 ENST00000614054.4
DCAKD
dephospho-CoA kinase domain containing
chr17_-_45051575 0.72 ENST00000588499.5
ENST00000593094.1
ENST00000651974.1
DCAKD
dephospho-CoA kinase domain containing
chr15_+_41256907 0.71 ENST00000560965.1
CHP1
calcineurin like EF-hand protein 1
chr19_+_49581304 0.71 ENST00000246794.10
PRRG2
proline rich and Gla domain 2
chr1_+_62436297 0.70 ENST00000452143.5
ENST00000442679.5
ENST00000371146.5
USP1
ubiquitin specific peptidase 1
chr22_-_41688799 0.69 ENST00000469028.2
ENST00000463675.6
ENST00000649479.1
ENST00000469522.1
SNU13
small nuclear ribonucleoprotein 13
chr16_+_30748241 0.68 ENST00000565924.5
ENST00000424889.7
PHKG2
phosphorylase kinase catalytic subunit gamma 2
chr10_+_67884646 0.68 ENST00000212015.11
SIRT1
sirtuin 1
chr5_-_116536458 0.64 ENST00000510263.5
SEMA6A
semaphorin 6A
chr18_+_13218769 0.64 ENST00000677055.1
ENST00000399848.7
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr7_-_78771108 0.62 ENST00000626691.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr16_+_30748378 0.61 ENST00000563588.6
ENST00000328273.11
PHKG2
phosphorylase kinase catalytic subunit gamma 2
chr4_+_39698156 0.61 ENST00000503368.5
ENST00000445950.2
UBE2K
ubiquitin conjugating enzyme E2 K
chr22_-_30266839 0.60 ENST00000403463.1
ENST00000215781.3
OSM
oncostatin M
chr20_+_44714835 0.60 ENST00000372868.6
CCN5
cellular communication network factor 5
chr19_-_49867251 0.59 ENST00000631020.2
ENST00000596014.5
ENST00000636994.1
PNKP
polynucleotide kinase 3'-phosphatase
chr22_+_26169474 0.59 ENST00000404234.7
ENST00000529632.6
ENST00000360929.7
ENST00000629590.2
ENST00000343706.8
SEZ6L
seizure related 6 homolog like
chr20_+_44714853 0.59 ENST00000372865.4
CCN5
cellular communication network factor 5
chr12_-_89708816 0.56 ENST00000428670.8
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr7_-_77199808 0.56 ENST00000248598.6
FGL2
fibrinogen like 2
chrX_-_107775951 0.55 ENST00000315660.8
ENST00000372384.6
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family member 3
chr6_+_106629560 0.54 ENST00000369046.8
QRSL1
glutaminyl-tRNA amidotransferase subunit QRSL1
chr20_+_44715360 0.52 ENST00000190983.5
CCN5
cellular communication network factor 5
chrX_-_48971829 0.51 ENST00000218176.4
KCND1
potassium voltage-gated channel subfamily D member 1
chr11_-_57237183 0.51 ENST00000606794.1
APLNR
apelin receptor
chr1_-_155990062 0.51 ENST00000462460.6
ARHGEF2
Rho/Rac guanine nucleotide exchange factor 2
chr2_-_174248360 0.51 ENST00000409546.5
ENST00000428402.6
ENST00000284719.8
OLA1
Obg like ATPase 1
chr4_+_113116676 0.50 ENST00000671971.1
ENST00000672240.1
ENST00000673240.1
ENST00000673363.1
ANK2
ankyrin 2
chr3_-_49813880 0.49 ENST00000333486.4
UBA7
ubiquitin like modifier activating enzyme 7
chr3_+_132660305 0.44 ENST00000683741.1
ENST00000468022.5
ENST00000356232.10
ENST00000473651.5
ENST00000494238.6
UBA5
ubiquitin like modifier activating enzyme 5
chr22_+_26169454 0.44 ENST00000248933.11
SEZ6L
seizure related 6 homolog like
chr12_-_31591129 0.44 ENST00000389082.10
DENND5B
DENN domain containing 5B
chr10_+_122163672 0.41 ENST00000369004.7
ENST00000260733.7
TACC2
transforming acidic coiled-coil containing protein 2
chr9_+_134326435 0.39 ENST00000481739.2
RXRA
retinoid X receptor alpha
chr2_+_45651650 0.37 ENST00000306156.8
PRKCE
protein kinase C epsilon
chr1_-_150268941 0.37 ENST00000369109.8
ENST00000236017.5
APH1A
aph-1 homolog A, gamma-secretase subunit
chr17_+_8002610 0.37 ENST00000254854.5
GUCY2D
guanylate cyclase 2D, retinal
chr1_+_24643264 0.34 ENST00000374389.8
ENST00000323848.14
ENST00000447431.6
SRRM1
serine and arginine repetitive matrix 1
chr11_+_4704782 0.33 ENST00000380390.6
MMP26
matrix metallopeptidase 26
chr1_+_35883189 0.30 ENST00000674304.1
ENST00000373204.6
ENST00000674426.1
AGO1
argonaute RISC component 1
chr11_-_35360050 0.29 ENST00000644868.1
ENST00000643454.1
ENST00000646080.1
SLC1A2
solute carrier family 1 member 2
chr18_-_26090584 0.28 ENST00000415083.7
SS18
SS18 subunit of BAF chromatin remodeling complex
chrX_+_44844015 0.26 ENST00000339042.6
DUSP21
dual specificity phosphatase 21
chr14_+_20688756 0.24 ENST00000397990.5
ENST00000555597.1
ANG
RNASE4
angiogenin
ribonuclease A family member 4
chr6_-_136289824 0.23 ENST00000527536.5
ENST00000529826.5
ENST00000531224.6
ENST00000353331.8
ENST00000628517.2
BCLAF1
BCL2 associated transcription factor 1
chr10_+_122163426 0.22 ENST00000360561.7
TACC2
transforming acidic coiled-coil containing protein 2
chr10_+_69124152 0.22 ENST00000395098.5
ENST00000263559.11
VPS26A
VPS26, retromer complex component A
chr8_+_28701487 0.22 ENST00000220562.9
EXTL3
exostosin like glycosyltransferase 3
chr3_-_24494791 0.21 ENST00000431815.5
ENST00000356447.9
ENST00000418247.1
ENST00000416420.5
ENST00000396671.7
THRB
thyroid hormone receptor beta
chr6_+_87322581 0.20 ENST00000608353.5
ENST00000392863.6
ENST00000229570.9
ENST00000608525.5
ENST00000608868.2
SMIM8
small integral membrane protein 8
chr5_+_141182369 0.20 ENST00000609684.3
ENST00000625044.1
ENST00000623407.1
ENST00000623884.1
PCDHB16
ENSG00000279068.1
protocadherin beta 16
novel transcript
chr1_+_203128279 0.19 ENST00000367235.1
ENST00000618295.1
ADORA1
adenosine A1 receptor
chr1_-_115841116 0.19 ENST00000320238.3
NHLH2
nescient helix-loop-helix 2
chr1_-_147773341 0.17 ENST00000430508.1
ENST00000621517.1
GJA5
gap junction protein alpha 5
chr1_+_201955496 0.17 ENST00000367287.5
TIMM17A
translocase of inner mitochondrial membrane 17A
chr11_+_68312542 0.17 ENST00000294304.12
LRP5
LDL receptor related protein 5
chr3_+_44874606 0.16 ENST00000296125.9
TGM4
transglutaminase 4
chr16_+_6019071 0.16 ENST00000547605.5
ENST00000553186.5
RBFOX1
RNA binding fox-1 homolog 1
chr14_+_22052503 0.15 ENST00000390449.3
TRAV21
T cell receptor alpha variable 21
chr21_-_33588624 0.14 ENST00000437395.5
ENST00000453626.5
ENST00000303113.10
ENST00000303071.10
ENST00000432378.5
DONSON
DNA replication fork stabilization factor DONSON
chr10_-_48604952 0.14 ENST00000417912.6
ARHGAP22
Rho GTPase activating protein 22
chr16_+_6019016 0.13 ENST00000550418.6
RBFOX1
RNA binding fox-1 homolog 1
chr10_-_67696115 0.12 ENST00000433211.7
CTNNA3
catenin alpha 3
chr12_-_51083582 0.12 ENST00000548206.1
ENST00000546935.5
ENST00000228515.6
ENST00000548981.5
CSRNP2
cysteine and serine rich nuclear protein 2
chr10_+_101131284 0.12 ENST00000370196.11
ENST00000467928.2
TLX1
T cell leukemia homeobox 1
chr11_+_34051722 0.11 ENST00000341394.9
ENST00000389645.7
CAPRIN1
cell cycle associated protein 1
chr10_-_48605032 0.10 ENST00000249601.9
ARHGAP22
Rho GTPase activating protein 22
chr17_+_50095331 0.10 ENST00000503176.6
PDK2
pyruvate dehydrogenase kinase 2
chr1_-_145859043 0.09 ENST00000369298.5
PIAS3
protein inhibitor of activated STAT 3
chr10_+_62374361 0.09 ENST00000395254.8
ZNF365
zinc finger protein 365
chr10_+_122163590 0.09 ENST00000368999.5
TACC2
transforming acidic coiled-coil containing protein 2
chr1_-_145859061 0.09 ENST00000393045.7
PIAS3
protein inhibitor of activated STAT 3
chr5_-_95284535 0.09 ENST00000515393.5
MCTP1
multiple C2 and transmembrane domain containing 1
chr3_-_24494875 0.09 ENST00000644321.1
THRB
thyroid hormone receptor beta
chr3_-_24494842 0.09 ENST00000646209.2
THRB
thyroid hormone receptor beta
chr20_-_21514046 0.08 ENST00000377142.5
NKX2-2
NK2 homeobox 2
chr7_+_6374491 0.08 ENST00000348035.9
ENST00000356142.4
RAC1
Rac family small GTPase 1
chrX_+_47223009 0.08 ENST00000518022.5
ENST00000276052.10
CDK16
cyclin dependent kinase 16
chr17_+_50095285 0.07 ENST00000503614.5
PDK2
pyruvate dehydrogenase kinase 2
chr2_+_170816562 0.07 ENST00000625689.2
ENST00000375272.5
GAD1
glutamate decarboxylase 1
chr1_+_46798998 0.06 ENST00000640628.1
ENST00000271153.8
ENST00000371923.9
ENST00000371919.8
ENST00000614163.4
CYP4B1
cytochrome P450 family 4 subfamily B member 1
chr1_-_150269051 0.04 ENST00000414276.6
ENST00000360244.8
APH1A
aph-1 homolog A, gamma-secretase subunit
chr5_-_170389349 0.04 ENST00000274629.9
KCNMB1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
chr6_-_24719146 0.03 ENST00000378119.9
C6orf62
chromosome 6 open reading frame 62
chr10_+_988425 0.03 ENST00000360803.9
GTPBP4
GTP binding protein 4
chr9_+_137788781 0.01 ENST00000482340.5
EHMT1
euchromatic histone lysine methyltransferase 1
chr20_-_62926469 0.00 ENST00000354665.8
ENST00000370368.5
ENST00000395340.5
ENST00000395343.6
DIDO1
death inducer-obliterator 1
chr1_-_155188351 0.00 ENST00000462317.5
MUC1
mucin 1, cell surface associated

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.7 2.1 GO:0036245 cellular response to menadione(GO:0036245)
0.7 2.0 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.6 2.5 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.6 4.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.5 2.0 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.5 2.4 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.5 1.4 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.4 2.6 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.3 1.4 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.3 1.3 GO:1903238 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943) positive regulation of leukocyte tethering or rolling(GO:1903238)
0.2 0.7 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.2 0.7 GO:0032761 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.2 0.7 GO:0051097 negative regulation of prostaglandin biosynthetic process(GO:0031393) negative regulation of helicase activity(GO:0051097) negative regulation of response to alcohol(GO:1901420)
0.2 1.3 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.2 0.4 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.2 1.5 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 0.5 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.2 1.5 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.2 1.3 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.2 1.6 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.2 2.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 1.8 GO:0001955 blood vessel maturation(GO:0001955)
0.1 1.1 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 1.2 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.1 0.5 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 1.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.8 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.9 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.1 0.7 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.1 0.6 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 1.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.1 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.1 3.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 3.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.6 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 5.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.2 GO:0070256 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.1 0.4 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 1.7 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.2 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.1 0.4 GO:0008050 negative regulation of female receptivity(GO:0007621) female courtship behavior(GO:0008050)
0.1 1.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 3.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.7 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.2 GO:0061304 bone marrow development(GO:0048539) retinal blood vessel morphogenesis(GO:0061304)
0.0 0.6 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 2.2 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651) activation of phospholipase A2 activity(GO:0032431)
0.0 0.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.4 GO:0070255 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.0 0.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.0 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 3.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.0 1.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 7.3 GO:0016042 lipid catabolic process(GO:0016042)
0.0 2.1 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.3 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.1 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 1.0 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0001651 dense fibrillar component(GO:0001651)
0.3 0.8 GO:0070195 growth hormone receptor complex(GO:0070195)
0.3 3.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 1.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 2.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.5 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.2 1.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.2 3.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 1.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.7 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 1.5 GO:0032433 filopodium tip(GO:0032433)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 3.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 8.6 GO:0035770 ribonucleoprotein granule(GO:0035770)
0.0 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 1.7 GO:0043195 terminal bouton(GO:0043195)
0.0 1.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.5 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.8 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.6 2.6 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.6 1.7 GO:0034512 box C/D snoRNA binding(GO:0034512)
0.4 4.8 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 1.4 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.3 1.3 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.3 2.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.3 1.4 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.2 1.5 GO:0005499 vitamin D binding(GO:0005499)
0.2 2.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 0.4 GO:0070644 vitamin D response element binding(GO:0070644)
0.2 1.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.5 GO:0050567 amidase activity(GO:0004040) glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.1 0.4 GO:0071566 UFM1 activating enzyme activity(GO:0071566)
0.1 0.7 GO:1990254 keratin filament binding(GO:1990254)
0.1 1.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.9 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 3.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.2 GO:0019864 IgG binding(GO:0019864)
0.1 2.0 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.1 1.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 1.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.4 GO:0035276 ethanol binding(GO:0035276)
0.1 2.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.5 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 3.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 2.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.6 GO:0043426 MRF binding(GO:0043426)
0.1 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 0.2 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.1 1.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 3.4 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.7 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.0 2.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 2.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 1.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0051021 thioesterase binding(GO:0031996) GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 3.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.7 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.2 GO:0019789 SUMO transferase activity(GO:0019789)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 4.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 2.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 2.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.5 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2 3.1 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 0.7 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 3.1 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 1.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 3.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 2.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 4.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.0 0.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.8 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 5.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 4.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.1 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 1.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes