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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX1-1

Z-value: 1.03

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.2 NKX1-1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_106360668 4.52 ENST00000633556.3
CRYBG1
crystallin beta-gamma domain containing 1
chr2_+_8682046 4.40 ENST00000331129.3
ENST00000396290.2
ID2
inhibitor of DNA binding 2
chr1_-_197146688 4.19 ENST00000294732.11
ASPM
assembly factor for spindle microtubules
chr1_-_197146620 4.17 ENST00000367409.9
ENST00000680265.1
ASPM
assembly factor for spindle microtubules
chr16_-_10942443 4.12 ENST00000570440.2
ENST00000331808.5
DEXI
Dexi homolog
chr1_+_155308748 3.76 ENST00000611010.4
ENST00000447866.5
ENST00000368356.9
ENST00000467076.5
ENST00000491013.5
ENST00000356657.10
FDPS
farnesyl diphosphate synthase
chr3_+_158801926 3.64 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
MFSD1
major facilitator superfamily domain containing 1
chr1_+_155308930 3.58 ENST00000465559.5
ENST00000612683.1
FDPS
farnesyl diphosphate synthase
chr17_+_47209375 2.98 ENST00000572303.1
MYL4
myosin light chain 4
chr18_+_58221535 2.81 ENST00000431212.6
ENST00000586268.5
ENST00000587190.5
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr12_-_102120065 2.66 ENST00000552283.6
ENST00000551744.2
NUP37
nucleoporin 37
chr12_+_28257195 2.58 ENST00000381259.5
CCDC91
coiled-coil domain containing 91
chr17_+_47209035 2.22 ENST00000572316.5
ENST00000354968.5
ENST00000576874.5
ENST00000536623.6
MYL4
myosin light chain 4
chr17_+_47209338 2.09 ENST00000393450.5
MYL4
myosin light chain 4
chr7_-_87220567 2.09 ENST00000433078.5
TMEM243
transmembrane protein 243
chrX_+_155216452 1.95 ENST00000286428.7
VBP1
VHL binding protein 1
chr19_-_8005590 1.93 ENST00000407627.7
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr2_-_46916020 1.90 ENST00000409800.5
ENST00000409218.5
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr10_-_1048879 1.90 ENST00000429642.2
IDI1
isopentenyl-diphosphate delta isomerase 1
chr10_-_1049110 1.88 ENST00000381344.8
IDI1
isopentenyl-diphosphate delta isomerase 1
chr19_+_10252206 1.81 ENST00000253099.11
ENST00000393733.6
ENST00000588502.5
MRPL4
mitochondrial ribosomal protein L4
chr11_-_111871530 1.80 ENST00000614444.4
ENST00000616540.5
ALG9
ALG9 alpha-1,2-mannosyltransferase
chr9_+_34646589 1.78 ENST00000450095.6
GALT
galactose-1-phosphate uridylyltransferase
chr9_+_34646654 1.76 ENST00000378842.8
GALT
galactose-1-phosphate uridylyltransferase
chr8_+_97644164 1.74 ENST00000336273.8
MTDH
metadherin
chr1_+_174874434 1.62 ENST00000478442.5
ENST00000465412.5
RABGAP1L
RAB GTPase activating protein 1 like
chr2_-_46915745 1.61 ENST00000649435.1
ENST00000409105.5
ENST00000319466.9
ENST00000409973.5
ENST00000409913.5
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chrX_-_23743201 1.57 ENST00000492081.1
ENST00000379303.10
ENST00000336430.11
ACOT9
acyl-CoA thioesterase 9
chrX_+_152831054 1.55 ENST00000370274.8
NSDHL
NAD(P) dependent steroid dehydrogenase-like
chr11_-_111871271 1.54 ENST00000398006.6
ALG9
ALG9 alpha-1,2-mannosyltransferase
chrX_+_19343893 1.52 ENST00000540249.5
ENST00000545074.5
ENST00000379806.9
ENST00000423505.5
ENST00000422285.7
ENST00000417819.5
ENST00000355808.9
ENST00000379805.3
PDHA1
pyruvate dehydrogenase E1 subunit alpha 1
chr3_+_23810436 1.45 ENST00000467766.5
ENST00000424381.5
UBE2E1
ubiquitin conjugating enzyme E2 E1
chr13_-_109786567 1.44 ENST00000375856.5
IRS2
insulin receptor substrate 2
chr6_-_31862809 1.29 ENST00000375631.5
NEU1
neuraminidase 1
chr7_+_26291850 1.21 ENST00000338523.9
ENST00000446848.6
SNX10
sorting nexin 10
chr17_+_82519694 1.17 ENST00000335255.10
FOXK2
forkhead box K2
chr2_-_238203611 1.17 ENST00000612675.4
ENST00000622223.4
ENST00000254654.8
ENST00000457149.1
ILKAP
ILK associated serine/threonine phosphatase
chr1_-_23344314 1.15 ENST00000374612.5
ENST00000675048.1
ENST00000478691.5
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr16_-_2268373 1.14 ENST00000566458.5
RNPS1
RNA binding protein with serine rich domain 1
chr1_-_23344259 1.06 ENST00000476451.2
ENST00000302271.11
ENST00000606561.5
ENST00000374616.7
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr11_+_19712823 1.05 ENST00000396085.6
ENST00000349880.9
NAV2
neuron navigator 2
chrY_-_1392101 1.01 ENST00000381401.11_PAR_Y
SLC25A6
solute carrier family 25 member 6
chr6_-_82247697 1.01 ENST00000306270.12
ENST00000610980.4
IBTK
inhibitor of Bruton tyrosine kinase
chrX_-_1392101 0.98 ENST00000381401.11
SLC25A6
solute carrier family 25 member 6
chr10_+_1049476 0.96 ENST00000358220.5
WDR37
WD repeat domain 37
chrX_+_55000329 0.92 ENST00000374987.4
APEX2
apurinic/apyrimidinic endodeoxyribonuclease 2
chr7_-_100119323 0.91 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chr16_-_2268054 0.83 ENST00000561518.5
ENST00000561718.5
ENST00000567147.5
ENST00000562690.5
ENST00000569598.6
RNPS1
RNA binding protein with serine rich domain 1
chr11_-_47176851 0.82 ENST00000629231.2
ENST00000526342.5
ENST00000528444.5
ENST00000530596.5
ENST00000525398.5
ENST00000524782.6
ENST00000527927.5
ENST00000525314.5
ARFGAP2
ADP ribosylation factor GTPase activating protein 2
chr17_-_4967790 0.80 ENST00000575142.5
ENST00000206020.8
SPAG7
sperm associated antigen 7
chr7_+_6009222 0.78 ENST00000400479.6
ENST00000223029.8
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
chrX_-_152830721 0.76 ENST00000370277.5
CETN2
centrin 2
chr15_+_64094060 0.71 ENST00000560829.5
SNX1
sorting nexin 1
chr1_-_107965009 0.69 ENST00000527011.5
ENST00000370056.9
VAV3
vav guanine nucleotide exchange factor 3
chr17_-_7263959 0.64 ENST00000571932.2
CLDN7
claudin 7
chr19_-_6424802 0.62 ENST00000600480.2
KHSRP
KH-type splicing regulatory protein
chr16_-_2268111 0.62 ENST00000301730.12
ENST00000564822.1
ENST00000320225.10
RNPS1
RNA binding protein with serine rich domain 1
chr2_+_216659600 0.61 ENST00000456764.1
IGFBP2
insulin like growth factor binding protein 2
chr17_-_47189176 0.57 ENST00000531206.5
ENST00000527547.5
ENST00000575483.5
ENST00000066544.8
CDC27
cell division cycle 27
chr17_-_63699730 0.56 ENST00000578061.5
LIMD2
LIM domain containing 2
chr19_+_49487510 0.54 ENST00000679106.1
ENST00000621674.4
ENST00000391857.9
ENST00000678510.1
ENST00000467825.2
RPL13A
ribosomal protein L13a
chr19_-_45782479 0.54 ENST00000447742.6
ENST00000354227.9
ENST00000291270.9
ENST00000683086.1
ENST00000343373.10
DMPK
DM1 protein kinase
chr5_+_157731400 0.53 ENST00000231198.12
THG1L
tRNA-histidine guanylyltransferase 1 like
chr7_-_100119840 0.51 ENST00000437822.6
TAF6
TATA-box binding protein associated factor 6
chr10_-_124418912 0.50 ENST00000368845.6
ENST00000539214.5
OAT
ornithine aminotransferase
chr12_+_102120172 0.46 ENST00000327680.7
ENST00000541394.5
ENST00000543784.5
PARPBP
PARP1 binding protein
chr11_+_134331874 0.46 ENST00000339772.9
ENST00000535456.7
GLB1L2
galactosidase beta 1 like 2
chr17_-_63700100 0.41 ENST00000578993.5
ENST00000259006.8
ENST00000583211.5
LIMD2
LIM domain containing 2
chr7_+_50308672 0.40 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKZF1
IKAROS family zinc finger 1
chr11_-_72112750 0.38 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
ANAPC15
anaphase promoting complex subunit 15
chr4_-_65670339 0.36 ENST00000273854.7
EPHA5
EPH receptor A5
chr1_-_221742074 0.27 ENST00000366899.4
DUSP10
dual specificity phosphatase 10
chr2_+_86720282 0.25 ENST00000283632.5
RMND5A
required for meiotic nuclear division 5 homolog A
chr7_+_120988683 0.25 ENST00000340646.9
ENST00000310396.10
CPED1
cadherin like and PC-esterase domain containing 1
chr19_-_45782388 0.24 ENST00000458663.6
DMPK
DM1 protein kinase
chr19_-_6424772 0.20 ENST00000619396.4
ENST00000398148.7
KHSRP
KH-type splicing regulatory protein
chr19_+_9835292 0.20 ENST00000247970.9
ENST00000587625.5
ENST00000588695.5
PIN1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
chr22_-_38755458 0.17 ENST00000405510.5
ENST00000433561.5
SUN2
Sad1 and UNC84 domain containing 2
chr11_-_2885728 0.17 ENST00000647251.1
ENST00000380725.2
ENST00000430149.3
ENST00000414822.8
ENST00000440480.8
CDKN1C
cyclin dependent kinase inhibitor 1C
chr4_-_65670478 0.16 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPHA5
EPH receptor A5
chrX_+_44844015 0.15 ENST00000339042.6
DUSP21
dual specificity phosphatase 21
chr12_+_2812638 0.13 ENST00000228799.7
ITFG2
integrin alpha FG-GAP repeat containing 2
chr11_-_45918014 0.11 ENST00000525192.5
PEX16
peroxisomal biogenesis factor 16
chr17_-_10469558 0.11 ENST00000255381.2
MYH4
myosin heavy chain 4
chr11_-_72112669 0.10 ENST00000545944.5
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr13_-_35476682 0.07 ENST00000379919.6
MAB21L1
mab-21 like 1
chr9_+_113463697 0.07 ENST00000317613.10
RGS3
regulator of G protein signaling 3
chr11_-_2139382 0.07 ENST00000416167.7
IGF2
insulin like growth factor 2
chr11_-_61161414 0.04 ENST00000301765.10
VPS37C
VPS37C subunit of ESCRT-I
chr1_-_51330527 0.02 ENST00000439482.6
TTC39A
tetratricopeptide repeat domain 39A
chr21_-_36542600 0.00 ENST00000399136.5
CLDN14
claudin 14

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.4 GO:0009786 regulation of asymmetric cell division(GO:0009786)
1.5 7.3 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
1.2 3.5 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.9 4.4 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
0.8 3.8 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.5 2.0 GO:0052031 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.2 1.4 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.2 2.8 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 2.6 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.2 1.1 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) glossopharyngeal nerve development(GO:0021563)
0.2 1.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 3.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.2 7.3 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.2 1.3 GO:0006689 ganglioside catabolic process(GO:0006689)
0.2 0.8 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.2 1.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 1.9 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.1 3.0 GO:0061157 mRNA destabilization(GO:0061157)
0.1 1.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 2.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 0.5 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 3.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 2.7 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 1.5 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.1 0.5 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 0.8 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 1.2 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 1.0 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.6 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 1.7 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.0 1.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.8 GO:0007099 centriole replication(GO:0007099)
0.0 0.6 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.7 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 1.6 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.9 GO:0006284 base-excision repair(GO:0006284)
0.0 0.6 GO:0007091 metaphase/anaphase transition of mitotic cell cycle(GO:0007091)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.4 GO:0036449 microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687)
0.3 1.9 GO:0016272 prefoldin complex(GO:0016272)
0.3 2.6 GO:0061574 ASAP complex(GO:0061574)
0.2 0.8 GO:0071942 XPC complex(GO:0071942)
0.2 1.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 1.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 1.0 GO:0070545 PeBoW complex(GO:0070545)
0.2 2.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 2.0 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 0.7 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 7.3 GO:0031672 A band(GO:0031672)
0.1 1.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.5 GO:0097452 GAIT complex(GO:0097452)
0.0 3.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.8 GO:0005771 multivesicular body(GO:0005771)
0.0 1.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.8 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 3.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.5 GO:0005811 lipid particle(GO:0005811)
0.0 2.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.3 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.2 7.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.8 3.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.5 1.5 GO:0047012 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity(GO:0047012)
0.5 2.0 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.4 1.3 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.4 1.5 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.4 3.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.3 1.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.3 3.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 0.9 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.2 2.8 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 0.8 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 2.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.7 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.5 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 1.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 1.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.6 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 0.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 1.4 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 1.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 3.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 8.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 4.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 2.2 GO:0044325 ion channel binding(GO:0044325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 6.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.2 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 12.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 7.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 4.6 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 1.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 1.4 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.1 2.6 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 3.5 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.9 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 2.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade