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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX1-2_RAX

Z-value: 3.39

Motif logo

Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
ENSG00000229544.9 NKX1-2
ENSG00000134438.10 RAX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAXhg38_v1_chr18_-_59273447_59273459,
hg38_v1_chr18_-_59273379_59273429
-0.557.8e-19Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_-_25863537 18.87 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L family member 3
chr3_-_64019334 18.47 ENST00000480205.5
proteasome 26S subunit, non-ATPase 6
chr7_-_88226965 15.29 ENST00000490437.5
ENST00000431660.5
sorcin
chr3_+_158801926 15.18 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
major facilitator superfamily domain containing 1
chr7_-_88226987 15.11 ENST00000394641.7
sorcin
chr2_+_186506713 13.70 ENST00000445547.1
zinc finger CCCH-type containing 15
chr10_+_123154768 13.67 ENST00000407911.2
BUB3 mitotic checkpoint protein
chr6_+_106360668 11.89 ENST00000633556.3
crystallin beta-gamma domain containing 1
chr4_-_102828022 10.93 ENST00000502690.5
ubiquitin conjugating enzyme E2 D3
chr4_-_102828048 9.97 ENST00000508249.1
ubiquitin conjugating enzyme E2 D3
chr10_+_123154414 9.03 ENST00000368858.9
BUB3 mitotic checkpoint protein
chr11_-_111871530 8.61 ENST00000614444.4
ENST00000616540.5
ALG9 alpha-1,2-mannosyltransferase
chr11_-_111871271 7.69 ENST00000398006.6
ALG9 alpha-1,2-mannosyltransferase
chrX_+_115593570 7.58 ENST00000539310.5
plastin 3
chr12_+_32679269 6.93 ENST00000358214.9
ENST00000553257.6
ENST00000549701.6
ENST00000266481.10
ENST00000551476.5
ENST00000550154.5
ENST00000547312.5
ENST00000381000.8
ENST00000548750.5
dynamin 1 like
chr12_+_32679200 6.31 ENST00000452533.6
ENST00000414834.6
dynamin 1 like
chr3_+_23810436 6.26 ENST00000467766.5
ENST00000424381.5
ubiquitin conjugating enzyme E2 E1
chr10_+_123154364 6.13 ENST00000368859.6
ENST00000368865.9
BUB3 mitotic checkpoint protein
chr1_+_155308748 6.00 ENST00000611010.4
ENST00000447866.5
ENST00000368356.9
ENST00000467076.5
ENST00000491013.5
ENST00000356657.10
farnesyl diphosphate synthase
chr2_-_219399981 5.93 ENST00000519905.1
ENST00000523282.5
ENST00000434339.5
ENST00000457935.5
aspartyl aminopeptidase
chr1_+_155308930 5.78 ENST00000465559.5
ENST00000612683.1
farnesyl diphosphate synthase
chr6_+_30720335 5.75 ENST00000327892.13
tubulin beta class I
chr2_-_86194972 5.66 ENST00000254636.9
inner membrane mitochondrial protein
chr5_+_154941063 5.62 ENST00000523037.6
ENST00000265229.12
ENST00000439747.7
ENST00000522038.5
mitochondrial ribosomal protein L22
chrX_+_77899440 5.08 ENST00000373335.4
ENST00000475465.1
ENST00000650309.2
ENST00000647835.1
cytochrome c oxidase subunit 7B
chr22_-_41946688 5.07 ENST00000404067.5
ENST00000402338.5
centromere protein M
chr4_-_102827723 4.97 ENST00000349311.12
ubiquitin conjugating enzyme E2 D3
chr7_+_101127095 4.73 ENST00000223095.5
serpin family E member 1
chr1_+_42682388 4.54 ENST00000321358.12
ENST00000332220.10
Y-box binding protein 1
chr1_-_16978276 4.51 ENST00000375534.7
microfibril associated protein 2
chr4_-_102828159 4.43 ENST00000394803.9
ubiquitin conjugating enzyme E2 D3
chr4_-_102827948 4.31 ENST00000394804.6
ENST00000394801.8
ubiquitin conjugating enzyme E2 D3
chr2_+_26786020 4.03 ENST00000335756.9
ENST00000233505.12
centromere protein A
chr1_+_226063466 3.93 ENST00000666609.1
ENST00000661429.1
H3.3 histone A
chr22_-_41947087 3.88 ENST00000407253.7
ENST00000215980.10
centromere protein M
chr3_+_184135343 3.57 ENST00000648915.2
ENST00000432569.2
ENST00000647909.1
eukaryotic translation initiation factor 2B subunit epsilon
chr19_-_6424802 3.57 ENST00000600480.2
KH-type splicing regulatory protein
chr20_+_45416551 3.52 ENST00000639292.1
phosphatidylinositol glycan anchor biosynthesis class T
chr7_-_87220567 3.52 ENST00000433078.5
transmembrane protein 243
chr1_+_153774210 3.26 ENST00000271857.6
solute carrier family 27 member 3
chr5_-_83673544 3.24 ENST00000503117.1
ENST00000510978.5
hyaluronan and proteoglycan link protein 1
chrX_-_152830721 3.05 ENST00000370277.5
centrin 2
chr15_+_64387828 2.93 ENST00000261884.8
thyroid hormone receptor interactor 4
chr2_+_216659600 2.85 ENST00000456764.1
insulin like growth factor binding protein 2
chr4_+_109815503 2.80 ENST00000394631.7
GAR1 ribonucleoprotein
chr9_+_122370523 2.78 ENST00000643810.1
ENST00000540753.6
prostaglandin-endoperoxide synthase 1
chr6_-_31862809 2.75 ENST00000375631.5
neuraminidase 1
chr7_+_55365317 2.72 ENST00000254770.3
LanC like 2
chr6_-_111606260 2.51 ENST00000340026.10
TRAF3 interacting protein 2
chr6_+_26365215 2.47 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr20_+_58907981 2.45 ENST00000656419.1
GNAS complex locus
chrX_+_152831054 2.43 ENST00000370274.8
NAD(P) dependent steroid dehydrogenase-like
chr6_+_26365176 2.36 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr11_-_3837858 2.34 ENST00000396979.1
ras homolog family member G
chr9_-_134068012 2.18 ENST00000303407.12
bromodomain containing 3
chr2_-_89143133 2.17 ENST00000492167.1
immunoglobulin kappa variable 3-20
chr9_+_122371014 2.17 ENST00000362012.7
prostaglandin-endoperoxide synthase 1
chr3_-_11643871 2.11 ENST00000430365.7
vestigial like family member 4
chr5_-_126595237 2.10 ENST00000637206.1
ENST00000553117.5
aldehyde dehydrogenase 7 family member A1
chr4_-_65670339 2.09 ENST00000273854.7
EPH receptor A5
chr1_+_186296267 2.02 ENST00000533951.5
ENST00000367482.8
ENST00000635041.1
ENST00000367483.8
ENST00000367485.4
ENST00000445192.7
proteoglycan 4
chr7_-_100119323 2.02 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TATA-box binding protein associated factor 6
chrX_+_77910656 1.97 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr4_-_65670478 1.95 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPH receptor A5
chr7_+_138460238 1.87 ENST00000343526.9
tripartite motif containing 24
chr13_+_48037692 1.76 ENST00000258662.3
nudix hydrolase 15
chr9_+_122371036 1.70 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
prostaglandin-endoperoxide synthase 1
chrX_-_41665766 1.64 ENST00000643043.2
ENST00000486402.1
ENST00000646087.2
calcium/calmodulin dependent serine protein kinase
chr8_-_96261579 1.64 ENST00000517720.1
ENST00000523821.5
ENST00000287025.4
mitochondrial transcription termination factor 3
chr19_+_49487510 1.62 ENST00000679106.1
ENST00000621674.4
ENST00000391857.9
ENST00000678510.1
ENST00000467825.2
ribosomal protein L13a
chr3_-_151316795 1.61 ENST00000260843.5
G protein-coupled receptor 87
chr20_-_1466904 1.59 ENST00000476071.5
NSFL1 cofactor
chr2_-_89297785 1.59 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr10_-_104085847 1.56 ENST00000648076.2
collagen type XVII alpha 1 chain
chr6_-_82247697 1.44 ENST00000306270.12
ENST00000610980.4
inhibitor of Bruton tyrosine kinase
chr20_-_1466822 1.37 ENST00000353088.6
ENST00000216879.9
NSFL1 cofactor
chr1_+_192636121 1.32 ENST00000543215.5
ENST00000391995.7
regulator of G protein signaling 13
chr2_+_90038848 1.27 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr17_-_7263959 1.27 ENST00000571932.2
claudin 7
chr10_-_112446891 1.24 ENST00000369404.3
ENST00000369405.7
ENST00000626395.2
zinc finger DHHC-type palmitoyltransferase 6
chr2_+_89884740 1.23 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr15_+_49170200 1.23 ENST00000396509.6
galactokinase 2
chr9_+_116687295 1.22 ENST00000450136.2
ENST00000373983.2
ENST00000411410.1
tripartite motif containing 32
chr12_-_21910853 1.19 ENST00000544039.5
ATP binding cassette subfamily C member 9
chr22_-_32255344 1.14 ENST00000266086.6
solute carrier family 5 member 4
chrX_+_44844015 1.09 ENST00000339042.6
dual specificity phosphatase 21
chr9_+_34646654 1.07 ENST00000378842.8
galactose-1-phosphate uridylyltransferase
chr5_-_95554944 1.07 ENST00000513823.5
ENST00000649566.1
ENST00000358746.7
ENST00000514952.5
tetratricopeptide repeat domain 37
chr10_-_112446734 0.99 ENST00000684507.1
zinc finger DHHC-type palmitoyltransferase 6
chr7_-_100119840 0.94 ENST00000437822.6
TATA-box binding protein associated factor 6
chr9_+_34646589 0.90 ENST00000450095.6
galactose-1-phosphate uridylyltransferase
chr3_-_165078480 0.88 ENST00000264382.8
sucrase-isomaltase
chr13_-_35476682 0.85 ENST00000379919.6
mab-21 like 1
chr6_+_26440472 0.83 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
butyrophilin subfamily 3 member A3
chr12_-_118359639 0.79 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr15_+_49170237 0.77 ENST00000560031.6
ENST00000558145.5
ENST00000544523.5
ENST00000560138.5
galactokinase 2
chr1_-_211134061 0.70 ENST00000639602.1
ENST00000638498.1
ENST00000367007.5
novel protein
potassium voltage-gated channel subfamily H member 1
chr22_+_22720615 0.64 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr12_-_9869345 0.63 ENST00000228438.3
C-type lectin domain family 2 member B
chr13_+_108629605 0.58 ENST00000457511.7
myosin XVI
chr9_+_34329545 0.56 ENST00000379158.7
nudix hydrolase 2
chrX_-_18672101 0.53 ENST00000379984.4
retinoschisin 1
chrX_+_136536099 0.51 ENST00000440515.5
ENST00000456412.1
vestigial like family member 1
chr12_-_12684490 0.51 ENST00000540510.1
G protein-coupled receptor 19
chr1_+_54715837 0.46 ENST00000371281.4
tetratricopeptide repeat domain 4
chr9_+_133061981 0.45 ENST00000372080.8
carboxyl ester lipase
chr7_+_120988683 0.45 ENST00000340646.9
ENST00000310396.10
cadherin like and PC-esterase domain containing 1
chr17_-_4967790 0.44 ENST00000575142.5
ENST00000206020.8
sperm associated antigen 7
chrX_+_19343893 0.41 ENST00000540249.5
ENST00000545074.5
ENST00000379806.9
ENST00000423505.5
ENST00000422285.7
ENST00000417819.5
ENST00000355808.9
ENST00000379805.3
pyruvate dehydrogenase E1 subunit alpha 1
chr12_-_10807286 0.40 ENST00000240615.3
taste 2 receptor member 8
chr16_-_28597042 0.40 ENST00000533150.5
ENST00000335715.9
sulfotransferase family 1A member 2
chr19_-_3985451 0.38 ENST00000309311.7
eukaryotic translation elongation factor 2
chr11_-_18236795 0.38 ENST00000278222.7
serum amyloid A4, constitutive
chr9_-_21240002 0.34 ENST00000380222.4
interferon alpha 14
chr6_-_111605859 0.28 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3 interacting protein 2
chr2_+_74455077 0.23 ENST00000431187.5
ENST00000233331.12
ENST00000409917.5
ENST00000409493.3
INO80 complex subunit B
chr6_+_154039102 0.20 ENST00000360422.8
ENST00000330432.12
opioid receptor mu 1
chr18_+_58341038 0.14 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chr19_-_6424772 0.11 ENST00000619396.4
ENST00000398148.7
KH-type splicing regulatory protein
chr19_-_45782479 0.08 ENST00000447742.6
ENST00000354227.9
ENST00000291270.9
ENST00000683086.1
ENST00000343373.10
DM1 protein kinase
chr1_-_151831768 0.07 ENST00000318247.7
RAR related orphan receptor C
chr14_-_99480831 0.06 ENST00000331768.10
ENST00000630307.2
SET domain containing 3, actin histidine methyltransferase
chr11_-_65858166 0.06 ENST00000308162.10
cofilin 1
chr7_+_50308672 0.04 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKAROS family zinc finger 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.2 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
4.3 30.4 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
2.4 11.8 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
1.6 4.7 GO:0001300 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.9 2.8 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.9 2.7 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.8 16.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.8 6.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.7 28.8 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.7 2.1 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.7 32.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.7 2.0 GO:0071284 copper ion export(GO:0060003) cellular response to lead ion(GO:0071284) regulation of electron carrier activity(GO:1904732)
0.7 2.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.6 4.5 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.4 3.5 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.4 5.7 GO:0042407 cristae formation(GO:0042407)
0.4 3.6 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.4 1.9 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.4 13.0 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3 2.7 GO:0006689 ganglioside catabolic process(GO:0006689)
0.3 7.6 GO:0051639 actin filament network formation(GO:0051639)
0.3 4.5 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.3 6.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 1.2 GO:0030047 actin modification(GO:0030047)
0.3 3.7 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.3 5.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 1.8 GO:0006203 dGTP catabolic process(GO:0006203)
0.2 18.5 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
0.2 4.0 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.2 1.6 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.2 2.4 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 2.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 0.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 2.0 GO:0006012 galactose metabolic process(GO:0006012)
0.1 1.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 0.5 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.1 3.0 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.1 2.2 GO:0018345 protein palmitoylation(GO:0018345)
0.1 2.8 GO:0010226 response to lithium ion(GO:0010226)
0.1 3.0 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 2.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 2.4 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.1 5.8 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 2.2 GO:0003094 glomerular filtration(GO:0003094)
0.1 5.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 2.3 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.1 0.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 1.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 2.9 GO:1901998 toxin transport(GO:1901998)
0.0 0.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 1.3 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 1.1 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.5 GO:0009642 response to light intensity(GO:0009642)
0.0 1.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 3.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.0 1.6 GO:0042255 ribosome assembly(GO:0042255)
0.0 1.3 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 1.9 GO:0030449 regulation of complement activation(GO:0030449)
0.0 3.0 GO:1901796 regulation of signal transduction by p53 class mediator(GO:1901796)
0.0 0.8 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 28.8 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
4.3 30.4 GO:0044326 dendritic spine neck(GO:0044326)
1.3 4.0 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.9 5.7 GO:0061617 MICOS complex(GO:0061617)
0.9 3.5 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.8 3.0 GO:0071942 XPC complex(GO:0071942)
0.7 3.0 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.7 2.2 GO:0071756 IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
0.6 18.5 GO:0005838 proteasome regulatory particle(GO:0005838)
0.4 3.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.4 4.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.4 1.6 GO:0097452 GAIT complex(GO:0097452)
0.4 2.8 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.4 1.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.4 1.1 GO:0055087 Ski complex(GO:0055087)
0.3 5.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.3 1.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.3 5.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 4.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 1.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 3.0 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 13.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 5.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 9.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 1.6 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.6 GO:0030056 hemidesmosome(GO:0030056)
0.1 7.6 GO:0032432 actin filament bundle(GO:0032432)
0.1 2.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 3.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 4.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 25.3 GO:0010008 endosome membrane(GO:0010008)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 3.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 2.7 GO:0035580 specific granule lumen(GO:0035580)
0.0 2.4 GO:0005811 lipid particle(GO:0005811)
0.0 3.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 5.8 GO:0072562 blood microparticle(GO:0072562)
0.0 2.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 4.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 16.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
2.4 11.8 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
1.3 6.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.3 6.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.9 2.7 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.9 3.5 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.8 2.4 GO:0000252 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity(GO:0047012)
0.8 34.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.8 30.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.7 13.2 GO:0051400 BH domain binding(GO:0051400)
0.7 2.0 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.7 2.0 GO:0004008 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.6 3.0 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.6 1.8 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.4 2.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.3 4.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 1.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.3 1.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.3 3.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 2.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 5.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 33.0 GO:0043130 ubiquitin binding(GO:0043130)
0.2 5.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 1.9 GO:0034056 estrogen response element binding(GO:0034056)
0.2 2.0 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 3.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 3.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 3.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.9 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 5.1 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 1.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 2.4 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 2.2 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.4 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 2.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 1.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 3.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 4.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 2.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 3.6 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.4 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 2.0 GO:0019843 rRNA binding(GO:0019843)
0.1 0.6 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 4.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 7.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 4.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 5.0 GO:0051015 actin filament binding(GO:0051015)
0.0 13.0 GO:0016887 ATPase activity(GO:0016887)
0.0 13.7 GO:0045296 cadherin binding(GO:0045296)
0.0 4.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0042056 chemoattractant activity(GO:0042056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 34.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 33.7 PID P73PATHWAY p73 transcription factor network
0.1 4.0 PID AURORA A PATHWAY Aurora A signaling
0.1 3.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 1.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 4.5 PID NOTCH PATHWAY Notch signaling pathway
0.1 4.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 2.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.4 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 33.0 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1.0 34.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.4 14.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.3 18.5 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.2 6.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 4.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.5 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 13.2 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 2.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 0.9 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.4 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 5.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 5.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 5.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.0 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 2.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 2.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 4.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 2.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 5.6 REACTOME TRANSLATION Genes involved in Translation
0.0 0.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 2.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives