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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX2-2

Z-value: 7.81

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
NKX2-2
ENSG00000125820.6 NKX2-2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-2hg38_v1_chr20_-_21514046_21514070-0.136.5e-02Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_64019334 40.16 ENST00000480205.5
PSMD6
proteasome 26S subunit, non-ATPase 6
chr11_-_11353241 35.48 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr3_+_159273235 33.64 ENST00000638749.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr8_-_100950549 28.52 ENST00000395951.7
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chrX_+_71254781 28.50 ENST00000677446.1
NONO
non-POU domain containing octamer binding
chr5_+_160421847 28.20 ENST00000352433.10
ENST00000517480.1
ENST00000520452.5
ENST00000393964.1
PTTG1
PTTG1 regulator of sister chromatid separation, securin
chr1_-_53940100 27.97 ENST00000371376.1
HSPB11
heat shock protein family B (small) member 11
chr2_-_150487658 27.82 ENST00000375734.6
ENST00000263895.9
ENST00000454202.5
RND3
Rho family GTPase 3
chr2_+_169798841 25.47 ENST00000260956.9
ENST00000417292.5
SSB
small RNA binding exonuclease protection factor La
chr9_+_128685062 24.79 ENST00000409104.7
SET
SET nuclear proto-oncogene
chr9_+_89311187 23.92 ENST00000314355.7
CKS2
CDC28 protein kinase regulatory subunit 2
chr19_+_47130782 22.27 ENST00000597808.5
ENST00000413379.7
ENST00000600706.5
ENST00000270225.12
ENST00000598840.5
ENST00000600753.1
ENST00000392776.3
SAE1
SUMO1 activating enzyme subunit 1
chr8_-_120445092 21.89 ENST00000518918.1
MRPL13
mitochondrial ribosomal protein L13
chr14_+_35278618 19.99 ENST00000540871.5
PSMA6
proteasome 20S subunit alpha 6
chr15_-_60398733 19.87 ENST00000559818.6
ANXA2
annexin A2
chr18_+_32091849 19.83 ENST00000261593.8
ENST00000578914.1
RNF138
ring finger protein 138
chr2_+_218245426 19.56 ENST00000456575.1
ARPC2
actin related protein 2/3 complex subunit 2
chr1_+_171512032 19.26 ENST00000426496.6
PRRC2C
proline rich coiled-coil 2C
chr10_-_103153609 18.30 ENST00000675985.1
NT5C2
5'-nucleotidase, cytosolic II
chr22_-_41690462 18.11 ENST00000648350.1
ENST00000402458.1
SNU13
small nuclear ribonucleoprotein 13
chr5_+_136059151 18.07 ENST00000503087.1
TGFBI
transforming growth factor beta induced
chr17_+_50746534 18.05 ENST00000511974.5
LUC7L3
LUC7 like 3 pre-mRNA splicing factor
chr3_+_23805941 17.81 ENST00000306627.8
ENST00000346855.7
UBE2E1
ubiquitin conjugating enzyme E2 E1
chr17_+_50746614 17.76 ENST00000513969.5
ENST00000503728.1
LUC7L3
LUC7 like 3 pre-mRNA splicing factor
chr8_-_120445140 17.68 ENST00000306185.8
MRPL13
mitochondrial ribosomal protein L13
chr10_-_119536533 16.88 ENST00000392865.5
RGS10
regulator of G protein signaling 10
chr19_+_38647679 16.61 ENST00000390009.7
ENST00000589528.1
ACTN4
actinin alpha 4
chr15_+_65550819 16.14 ENST00000569894.5
HACD3
3-hydroxyacyl-CoA dehydratase 3
chr8_+_26293112 15.86 ENST00000523925.5
ENST00000315985.7
PPP2R2A
protein phosphatase 2 regulatory subunit Balpha
chrX_-_71255060 15.82 ENST00000373988.5
ENST00000373998.5
ZMYM3
zinc finger MYM-type containing 3
chr14_-_100375333 15.79 ENST00000557297.5
ENST00000555813.5
ENST00000392882.7
ENST00000557135.5
ENST00000556698.5
ENST00000554509.5
ENST00000555410.5
WARS1
tryptophanyl-tRNA synthetase 1
chr1_-_244862381 15.75 ENST00000640001.1
ENST00000639628.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr7_+_2354810 15.71 ENST00000360876.9
ENST00000413917.5
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3 subunit B
chr15_+_63529142 15.61 ENST00000268049.11
USP3
ubiquitin specific peptidase 3
chr1_-_74733253 15.22 ENST00000417775.5
CRYZ
crystallin zeta
chr8_+_11809135 15.19 ENST00000528643.5
ENST00000525777.5
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr1_-_45521854 14.99 ENST00000372079.1
ENST00000319248.13
PRDX1
peroxiredoxin 1
chr8_-_140800535 14.14 ENST00000521986.5
ENST00000523539.5
PTK2
protein tyrosine kinase 2
chr5_+_83471764 13.97 ENST00000512590.6
ENST00000513960.5
ENST00000513984.5
VCAN
versican
chr5_-_43557689 13.87 ENST00000338972.8
ENST00000511321.5
ENST00000515338.1
PAIP1
poly(A) binding protein interacting protein 1
chr8_+_11808417 13.80 ENST00000525954.5
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr1_+_53014926 13.53 ENST00000430330.6
ENST00000408941.7
ENST00000478274.6
ENST00000484100.5
ENST00000435345.6
ENST00000488965.1
SCP2
sterol carrier protein 2
chr3_+_152299392 13.37 ENST00000498502.5
ENST00000545754.5
ENST00000357472.7
ENST00000324196.9
MBNL1
muscleblind like splicing regulator 1
chr1_-_45521931 13.26 ENST00000447184.6
ENST00000262746.5
PRDX1
peroxiredoxin 1
chrX_+_123961696 13.24 ENST00000371145.8
ENST00000371157.7
ENST00000371144.7
STAG2
stromal antigen 2
chr15_+_78873030 13.23 ENST00000558502.5
MORF4L1
mortality factor 4 like 1
chr5_+_83471668 13.21 ENST00000342785.8
ENST00000343200.9
VCAN
versican
chr14_-_100375602 13.08 ENST00000553395.5
ENST00000553545.5
ENST00000344102.9
ENST00000556338.5
ENST00000553934.1
WARS1
tryptophanyl-tRNA synthetase 1
chr5_+_136058849 12.94 ENST00000508076.5
TGFBI
transforming growth factor beta induced
chr5_+_83471925 12.80 ENST00000502527.2
VCAN
versican
chr22_-_35824373 12.69 ENST00000473487.6
RBFOX2
RNA binding fox-1 homolog 2
chr6_-_149746497 12.65 ENST00000367404.8
ENST00000340413.7
ENST00000543637.1
NUP43
nucleoporin 43
chr3_+_184174846 12.62 ENST00000427072.5
ENST00000411763.6
ENST00000292807.9
ENST00000448139.5
ENST00000455925.1
AP2M1
adaptor related protein complex 2 subunit mu 1
chr12_+_56152579 12.54 ENST00000551834.5
ENST00000552568.5
MYL6B
myosin light chain 6B
chr12_-_119877270 12.28 ENST00000261833.11
ENST00000612548.4
CIT
citron rho-interacting serine/threonine kinase
chr8_-_100706763 12.24 ENST00000517990.5
PABPC1
poly(A) binding protein cytoplasmic 1
chrX_-_23743201 12.09 ENST00000492081.1
ENST00000379303.10
ENST00000336430.11
ACOT9
acyl-CoA thioesterase 9
chr20_+_11890785 12.03 ENST00000399006.6
ENST00000405977.5
BTBD3
BTB domain containing 3
chr8_-_100706931 11.97 ENST00000520868.5
PABPC1
poly(A) binding protein cytoplasmic 1
chr5_+_83471736 11.95 ENST00000265077.8
VCAN
versican
chr12_-_89656093 11.85 ENST00000359142.7
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr7_+_116222804 11.80 ENST00000393481.6
TES
testin LIM domain protein
chr18_+_9103959 11.72 ENST00000400033.1
NDUFV2
NADH:ubiquinone oxidoreductase core subunit V2
chr7_+_32979445 11.41 ENST00000418354.5
ENST00000490776.3
FKBP9
FKBP prolyl isomerase 9
chr9_+_69205141 11.36 ENST00000649134.1
ENST00000539225.2
ENST00000650084.1
ENST00000648402.1
TJP2
tight junction protein 2
chr1_-_36149450 11.22 ENST00000373163.5
TRAPPC3
trafficking protein particle complex 3
chr17_+_68525795 11.15 ENST00000592800.5
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr8_-_86514332 11.09 ENST00000523911.5
RMDN1
regulator of microtubule dynamics 1
chr2_+_10368645 11.07 ENST00000613496.4
HPCAL1
hippocalcin like 1
chr5_+_119476530 10.80 ENST00000645099.1
ENST00000513628.5
HSD17B4
hydroxysteroid 17-beta dehydrogenase 4
chr6_+_158312459 10.69 ENST00000367097.8
TULP4
TUB like protein 4
chr2_+_10368764 10.54 ENST00000620771.4
HPCAL1
hippocalcin like 1
chr8_-_48921419 10.45 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chr6_+_32969345 10.45 ENST00000678250.1
BRD2
bromodomain containing 2
chr5_+_163503075 10.42 ENST00000280969.9
MAT2B
methionine adenosyltransferase 2B
chr3_-_197226351 10.35 ENST00000656428.1
DLG1
discs large MAGUK scaffold protein 1
chr1_-_246507237 10.32 ENST00000490107.6
SMYD3
SET and MYND domain containing 3
chr12_+_10505602 9.90 ENST00000322446.3
EIF2S3B
eukaryotic translation initiation factor 2 subunit gamma B
chr12_-_76559793 9.85 ENST00000549646.5
ENST00000550628.5
ENST00000553139.5
ENST00000611266.4
ENST00000393250.8
OSBPL8
oxysterol binding protein like 8
chr1_+_84164370 9.83 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr20_+_58651785 9.79 ENST00000358029.8
STX16
syntaxin 16
chr8_+_11803012 9.77 ENST00000528812.5
ENST00000622850.2
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr2_-_55049184 9.72 ENST00000357376.7
RTN4
reticulon 4
chr6_+_32969165 9.70 ENST00000496118.2
ENST00000449085.4
BRD2
bromodomain containing 2
chr18_+_58221535 9.57 ENST00000431212.6
ENST00000586268.5
ENST00000587190.5
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr16_+_53207981 9.29 ENST00000565803.2
CHD9
chromodomain helicase DNA binding protein 9
chr12_-_119877300 9.24 ENST00000392521.7
CIT
citron rho-interacting serine/threonine kinase
chr2_+_201129483 9.09 ENST00000440180.5
CFLAR
CASP8 and FADD like apoptosis regulator
chr1_-_155910881 9.04 ENST00000609492.1
ENST00000368322.7
RIT1
Ras like without CAAX 1
chr15_-_55917129 8.96 ENST00000338963.6
ENST00000508342.5
NEDD4
NEDD4 E3 ubiquitin protein ligase
chr8_-_140764386 8.90 ENST00000520151.5
ENST00000519024.5
ENST00000519465.5
PTK2
protein tyrosine kinase 2
chr17_+_54900746 8.89 ENST00000445275.6
TOM1L1
target of myb1 like 1 membrane trafficking protein
chr3_+_100709290 8.62 ENST00000675047.1
ENST00000490574.6
ENST00000675543.1
ENST00000676308.1
ENST00000675499.1
TFG
trafficking from ER to golgi regulator
chr19_+_38647614 8.58 ENST00000252699.7
ENST00000424234.7
ENST00000440400.2
ACTN4
actinin alpha 4
chr1_-_36149464 8.55 ENST00000373166.8
ENST00000373159.1
ENST00000373162.5
ENST00000616074.4
ENST00000616395.4
TRAPPC3
trafficking protein particle complex 3
chr3_+_100709344 8.45 ENST00000418917.7
ENST00000675553.1
TFG
trafficking from ER to golgi regulator
chr15_+_78872954 8.42 ENST00000558746.5
ENST00000558830.5
ENST00000559345.5
MORF4L1
mortality factor 4 like 1
chr3_+_100709382 8.21 ENST00000620299.5
TFG
trafficking from ER to golgi regulator
chr10_-_110918934 8.17 ENST00000605742.5
BBIP1
BBSome interacting protein 1
chr1_-_23559490 8.05 ENST00000374561.6
ID3
inhibitor of DNA binding 3, HLH protein
chr14_-_20333306 8.01 ENST00000353689.8
ENST00000437553.6
CCNB1IP1
cyclin B1 interacting protein 1
chr1_+_171557845 7.57 ENST00000644916.1
PRRC2C
proline rich coiled-coil 2C
chr3_+_38165484 7.56 ENST00000446845.5
ENST00000311806.8
OXSR1
oxidative stress responsive kinase 1
chr5_-_44389407 7.37 ENST00000264664.5
FGF10
fibroblast growth factor 10
chr8_+_11802667 7.36 ENST00000443614.6
ENST00000220584.9
ENST00000525900.5
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr8_+_11802611 7.27 ENST00000623368.3
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr10_+_13586933 7.22 ENST00000417658.5
ENST00000378572.8
ENST00000320054.4
PRPF18
pre-mRNA processing factor 18
chr12_+_56152439 7.11 ENST00000550443.5
MYL6B
myosin light chain 6B
chr2_+_188292814 7.09 ENST00000409580.5
ENST00000409637.7
GULP1
GULP PTB domain containing engulfment adaptor 1
chr1_-_31065671 7.03 ENST00000440538.6
ENST00000424085.6
ENST00000257075.9
ENST00000373747.7
ENST00000426105.7
ENST00000525843.5
ENST00000373742.6
PUM1
pumilio RNA binding family member 1
chr14_-_20333268 7.03 ENST00000358932.9
ENST00000557665.5
CCNB1IP1
cyclin B1 interacting protein 1
chr3_-_197184131 7.02 ENST00000452595.5
DLG1
discs large MAGUK scaffold protein 1
chr2_+_188292771 6.91 ENST00000359135.7
GULP1
GULP PTB domain containing engulfment adaptor 1
chr6_+_151239951 6.79 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chrX_+_11760035 6.71 ENST00000482871.6
ENST00000648013.1
MSL3
MSL complex subunit 3
chr17_-_56961014 6.66 ENST00000240316.5
COIL
coilin
chr16_+_30201057 6.65 ENST00000569485.5
SULT1A3
sulfotransferase family 1A member 3
chr15_-_55917080 6.62 ENST00000506154.1
NEDD4
NEDD4 E3 ubiquitin protein ligase
chr6_+_32968557 6.43 ENST00000374825.9
BRD2
bromodomain containing 2
chr19_-_2427538 6.34 ENST00000591871.1
ENST00000215570.8
TIMM13
translocase of inner mitochondrial membrane 13
chr20_+_58651228 6.29 ENST00000361830.7
ENST00000458280.5
ENST00000355957.9
ENST00000312283.12
ENST00000412911.5
ENST00000359617.8
ENST00000371141.8
STX16
syntaxin 16
chr4_+_41935114 6.19 ENST00000508448.5
ENST00000513702.5
ENST00000325094.9
TMEM33
transmembrane protein 33
chr17_+_77319465 6.18 ENST00000329047.13
SEPTIN9
septin 9
chrX_+_11760087 6.15 ENST00000649271.1
MSL3
MSL complex subunit 3
chr15_+_78872809 6.14 ENST00000331268.9
MORF4L1
mortality factor 4 like 1
chr3_-_15798184 6.13 ENST00000624145.3
ANKRD28
ankyrin repeat domain 28
chr15_+_67067780 6.11 ENST00000679624.1
SMAD3
SMAD family member 3
chr2_+_161231078 5.99 ENST00000439442.1
TANK
TRAF family member associated NFKB activator
chr11_+_65182413 5.93 ENST00000531068.5
ENST00000527699.5
ENST00000533909.5
ENST00000527323.5
CAPN1
calpain 1
chr7_+_80135694 5.75 ENST00000457358.7
GNAI1
G protein subunit alpha i1
chr6_+_151240368 5.75 ENST00000253332.5
AKAP12
A-kinase anchoring protein 12
chr12_+_20810698 5.64 ENST00000540853.5
ENST00000381545.8
SLCO1B3
solute carrier organic anion transporter family member 1B3
chrX_+_48476021 5.63 ENST00000396894.8
ENST00000019019.6
ENST00000348411.3
FTSJ1
FtsJ RNA 2'-O-methyltransferase 1
chr16_+_30200729 5.40 ENST00000563322.5
SULT1A3
sulfotransferase family 1A member 3
chr8_+_109540075 5.29 ENST00000614147.1
ENST00000337573.10
EBAG9
estrogen receptor binding site associated antigen 9
chr5_+_141223332 5.15 ENST00000239449.7
ENST00000624896.1
ENST00000624396.1
PCDHB14
ENSG00000279983.1
protocadherin beta 14
novel protein
chr5_-_179620933 5.15 ENST00000521173.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr5_+_168291599 5.08 ENST00000265293.9
WWC1
WW and C2 domain containing 1
chr19_-_39391029 5.05 ENST00000221265.8
PAF1
PAF1 homolog, Paf1/RNA polymerase II complex component
chr10_+_103245887 4.99 ENST00000441178.2
RPEL1
ribulose-5-phosphate-3-epimerase like 1
chr15_+_78872881 4.98 ENST00000559930.5
ENST00000426013.7
MORF4L1
mortality factor 4 like 1
chr18_-_46104217 4.93 ENST00000590406.5
ENST00000282050.6
ENST00000590324.5
ATP5F1A
ATP synthase F1 subunit alpha
chr10_-_102502702 4.93 ENST00000369905.9
ACTR1A
actin related protein 1A
chr9_+_2159672 4.89 ENST00000634343.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_-_36370171 4.83 ENST00000355182.8
SPART
spartin
chr11_+_31650024 4.74 ENST00000638317.1
ELP4
elongator acetyltransferase complex subunit 4
chr8_+_96584920 4.55 ENST00000521590.5
SDC2
syndecan 2
chr5_+_126423176 4.52 ENST00000542322.5
ENST00000544396.5
GRAMD2B
GRAM domain containing 2B
chr20_+_58888779 4.45 ENST00000488546.6
ENST00000667293.2
ENST00000481039.6
ENST00000467321.6
GNAS
GNAS complex locus
chr8_+_109540602 4.38 ENST00000530629.5
ENST00000620557.4
EBAG9
estrogen receptor binding site associated antigen 9
chrX_-_71254106 4.36 ENST00000373984.7
ENST00000314425.9
ENST00000373982.5
ZMYM3
zinc finger MYM-type containing 3
chr10_-_102502669 4.33 ENST00000487599.1
ACTR1A
actin related protein 1A
chr2_+_69893940 4.29 ENST00000244227.8
ENST00000409116.5
SNRNP27
small nuclear ribonucleoprotein U4/U6.U5 subunit 27
chr5_+_126423363 4.24 ENST00000285689.8
GRAMD2B
GRAM domain containing 2B
chr5_+_126423122 4.14 ENST00000515200.5
GRAMD2B
GRAM domain containing 2B
chrX_+_153687918 4.06 ENST00000253122.10
SLC6A8
solute carrier family 6 member 8
chr16_+_22490337 3.90 ENST00000415833.6
NPIPB5
nuclear pore complex interacting protein family member B5
chr7_+_150368189 3.72 ENST00000519397.1
ENST00000479668.5
REPIN1
replication initiator 1
chr16_-_1771495 3.63 ENST00000564628.1
ENST00000219302.8
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr2_-_219571241 3.60 ENST00000373876.5
ENST00000603926.5
ENST00000373873.8
ENST00000289656.3
OBSL1
obscurin like cytoskeletal adaptor 1
chr14_-_49688201 3.58 ENST00000553805.2
ENST00000554396.5
ENST00000216367.10
POLE2
DNA polymerase epsilon 2, accessory subunit
chr8_-_121641424 3.55 ENST00000303924.5
HAS2
hyaluronan synthase 2
chr17_+_76376581 3.43 ENST00000591651.5
ENST00000545180.5
SPHK1
sphingosine kinase 1
chr19_-_43670153 3.41 ENST00000601723.5
ENST00000339082.7
ENST00000340093.8
PLAUR
plasminogen activator, urokinase receptor
chr22_-_29555178 3.27 ENST00000418021.1
THOC5
THO complex 5
chr6_-_30672984 3.25 ENST00000415603.1
ENST00000376442.8
DHX16
DEAH-box helicase 16
chr1_+_211259932 3.25 ENST00000367005.8
RCOR3
REST corepressor 3
chr4_+_55853639 3.24 ENST00000381295.7
ENST00000346134.11
ENST00000349598.6
EXOC1
exocyst complex component 1
chr5_+_148394712 3.22 ENST00000513826.1
FBXO38
F-box protein 38
chr6_+_143677935 3.22 ENST00000440869.6
ENST00000367582.7
ENST00000451827.6
PHACTR2
phosphatase and actin regulator 2
chr12_-_10826358 3.21 ENST00000240619.2
TAS2R10
taste 2 receptor member 10
chr20_-_13784880 3.20 ENST00000202816.5
ENST00000617257.2
ESF1
ESF1 nucleolar pre-rRNA processing protein homolog
chr12_-_10802627 2.91 ENST00000240687.2
TAS2R7
taste 2 receptor member 7
chr17_+_7688427 2.85 ENST00000396463.7
ENST00000534050.5
WRAP53
WD repeat containing antisense to TP53
chr12_-_57846686 2.82 ENST00000548823.1
ENST00000398073.7
CTDSP2
CTD small phosphatase 2
chr10_+_13161543 2.81 ENST00000378714.8
ENST00000479669.5
ENST00000484800.6
MCM10
minichromosome maintenance 10 replication initiation factor
chr14_+_22493910 2.75 ENST00000390492.1
TRAJ45
T cell receptor alpha joining 45
chr12_-_10723307 2.74 ENST00000279550.11
ENST00000228251.9
YBX3
Y-box binding protein 3
chr17_-_44066595 2.70 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr7_-_139109702 2.68 ENST00000471652.1
ENST00000242351.10
ZC3HAV1
zinc finger CCCH-type containing, antiviral 1
chr12_-_68302872 2.58 ENST00000539972.5
MDM1
Mdm1 nuclear protein
chr12_-_124914056 2.47 ENST00000541272.1
ENST00000535131.1
UBC
ubiquitin C
chrX_+_108439866 2.43 ENST00000361603.7
COL4A5
collagen type IV alpha 5 chain
chr12_-_111488538 2.41 ENST00000389154.7
ATXN2
ataxin 2
chr10_-_59753444 2.35 ENST00000594536.5
ENST00000414264.6
MRLN
myoregulin
chr14_-_94081183 2.35 ENST00000330836.9
ENST00000621632.5
ENST00000544005.5
ENST00000555054.1
ENST00000640432.1
DDX24
DEAD-box helicase 24
chr3_-_179243284 2.34 ENST00000486944.2
KCNMB3
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr1_+_224114084 2.32 ENST00000424254.6
ENST00000366862.10
FBXO28
F-box protein 28
chr15_-_56465130 2.27 ENST00000260453.4
MNS1
meiosis specific nuclear structural 1
chr11_-_72721908 2.25 ENST00000426523.5
ENST00000429686.5
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr12_-_27971970 2.14 ENST00000395872.5
ENST00000201015.8
PTHLH
parathyroid hormone like hormone
chr14_+_39233884 2.00 ENST00000553728.1
MIA2
MIA SH3 domain ER export factor 2
chr3_-_114179052 1.91 ENST00000383673.5
ENST00000295881.9
DRD3
dopamine receptor D3
chr11_+_108008880 1.89 ENST00000393094.7
CUL5
cullin 5
chr12_-_8650529 1.86 ENST00000543467.5
MFAP5
microfibril associated protein 5
chr7_+_92057602 1.84 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9
chr13_-_75366973 1.81 ENST00000648194.1
TBC1D4
TBC1 domain family member 4
chr4_-_110641920 1.81 ENST00000354925.6
ENST00000511990.1
ENST00000613094.4
ENST00000614423.4
ENST00000616641.4
ENST00000511837.5
PITX2
paired like homeodomain 2
chr12_-_71157872 1.74 ENST00000546561.2
TSPAN8
tetraspanin 8
chr10_+_5094405 1.72 ENST00000380554.5
AKR1C3
aldo-keto reductase family 1 member C3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 53.4 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
7.1 35.5 GO:0044111 development involved in symbiotic interaction(GO:0044111)
4.2 25.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
4.2 25.2 GO:0048549 positive regulation of pinocytosis(GO:0048549)
3.6 10.8 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
3.5 10.5 GO:1901420 negative regulation of response to alcohol(GO:1901420)
2.9 28.5 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
2.8 19.8 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
2.6 10.4 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
2.5 7.6 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
2.5 7.4 GO:0060661 male genitalia morphogenesis(GO:0048808) bronchiole development(GO:0060435) submandibular salivary gland formation(GO:0060661) white fat cell proliferation(GO:0070343) positive regulation of fat cell proliferation(GO:0070346) regulation of white fat cell proliferation(GO:0070350) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) male anatomical structure morphogenesis(GO:0090598)
2.4 7.2 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
2.3 16.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
2.3 13.5 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
2.2 17.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
2.2 28.5 GO:0090168 Golgi reassembly(GO:0090168)
2.2 51.9 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
2.1 32.0 GO:0070986 left/right axis specification(GO:0070986)
2.0 12.0 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
2.0 11.8 GO:1990034 calcium ion export from cell(GO:1990034)
1.9 24.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.8 12.7 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
1.8 18.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
1.7 15.7 GO:0075525 viral translational termination-reinitiation(GO:0075525)
1.7 15.0 GO:0051026 chiasma assembly(GO:0051026)
1.6 23.0 GO:0051964 netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964)
1.6 9.8 GO:0097338 response to clozapine(GO:0097338)
1.6 43.7 GO:0043968 histone H2A acetylation(GO:0043968)
1.5 6.2 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.4 11.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
1.4 9.9 GO:0090204 protein localization to nuclear pore(GO:0090204)
1.2 17.4 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
1.1 3.4 GO:0046521 sphingoid catabolic process(GO:0046521)
1.1 18.3 GO:0046085 adenosine metabolic process(GO:0046085)
1.1 3.4 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
1.1 15.8 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.1 13.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.0 12.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.0 6.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
1.0 6.0 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.0 5.0 GO:0019323 pentose catabolic process(GO:0019323)
1.0 9.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.0 15.2 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.9 16.1 GO:0090161 Golgi ribbon formation(GO:0090161)
0.9 8.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.9 3.5 GO:0070295 renal water absorption(GO:0070295)
0.9 19.6 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.8 36.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.8 16.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.8 9.6 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.8 11.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.8 3.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.8 7.0 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.8 8.4 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.8 28.2 GO:0045143 homologous chromosome segregation(GO:0045143)
0.8 4.5 GO:0008218 bioluminescence(GO:0008218)
0.7 5.1 GO:0016584 nucleosome positioning(GO:0016584)
0.7 15.9 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.7 23.0 GO:0006337 nucleosome disassembly(GO:0006337)
0.7 6.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.7 2.8 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.6 62.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.6 2.4 GO:1902080 regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.6 51.2 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.6 1.7 GO:0016107 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.6 23.9 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.5 12.6 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.5 5.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.5 8.9 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.5 23.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.5 37.0 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.5 15.2 GO:0016578 histone deubiquitination(GO:0016578)
0.5 16.6 GO:0048255 mRNA stabilization(GO:0048255)
0.4 8.0 GO:0030903 notochord development(GO:0030903)
0.4 5.7 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.4 2.9 GO:0090666 telomere assembly(GO:0032202) scaRNA localization to Cajal body(GO:0090666)
0.4 2.7 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.4 5.9 GO:0060056 mammary gland involution(GO:0060056)
0.4 5.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.4 22.4 GO:0042348 regulation of NF-kappaB import into nucleus(GO:0042345) NF-kappaB import into nucleus(GO:0042348)
0.3 3.9 GO:0060215 primitive hemopoiesis(GO:0060215)
0.3 3.2 GO:0051601 exocyst localization(GO:0051601)
0.3 31.1 GO:0006334 nucleosome assembly(GO:0006334)
0.3 1.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.3 0.9 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.3 4.4 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.3 10.7 GO:0061512 protein localization to cilium(GO:0061512)
0.3 4.1 GO:0006600 creatine metabolic process(GO:0006600)
0.3 1.8 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.2 10.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 2.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.2 15.7 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2 11.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 1.8 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.2 21.7 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 3.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 3.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.2 0.7 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.2 1.5 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.2 2.4 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 13.9 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 0.1 GO:1905069 neural fold elevation formation(GO:0021502) allantois development(GO:1905069)
0.1 1.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 31.5 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.1 1.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 18.5 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 5.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 21.7 GO:0007601 visual perception(GO:0007601)
0.1 2.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 4.7 GO:0043967 histone H4 acetylation(GO:0043967)
0.1 2.8 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.9 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 2.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.4 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 9.1 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 2.8 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 2.4 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 4.4 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.3 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 1.3 GO:0042752 regulation of circadian rhythm(GO:0042752)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.6 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
5.6 22.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
3.6 18.1 GO:0001651 dense fibrillar component(GO:0001651)
3.5 10.4 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
3.2 28.5 GO:0042382 paraspeckles(GO:0042382)
2.8 19.9 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
2.3 11.7 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
1.7 35.8 GO:0071004 U2-type prespliceosome(GO:0071004)
1.7 20.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.6 19.8 GO:0030008 TRAPP complex(GO:0030008)
1.6 32.8 GO:0016580 Sin3 complex(GO:0016580)
1.6 15.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
1.5 9.3 GO:0002177 manchette(GO:0002177)
1.4 10.9 GO:0072487 MSL complex(GO:0072487)
1.3 40.2 GO:0005838 proteasome regulatory particle(GO:0005838)
1.3 5.1 GO:1990393 3M complex(GO:1990393)
1.2 28.0 GO:0030992 intraciliary transport particle B(GO:0030992)
1.1 15.6 GO:0070938 contractile ring(GO:0070938)
1.0 19.7 GO:0016461 unconventional myosin complex(GO:0016461)
1.0 8.2 GO:0034464 BBSome(GO:0034464)
1.0 21.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.0 15.8 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.9 37.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.9 17.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.8 25.2 GO:0031143 pseudopodium(GO:0031143)
0.8 3.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.8 21.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.7 12.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.7 3.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.7 6.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.7 6.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.7 16.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.7 36.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.6 21.0 GO:0035861 site of double-strand break(GO:0035861)
0.6 12.6 GO:0036020 endolysosome membrane(GO:0036020)
0.5 15.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.5 10.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.5 1.8 GO:0044307 dendritic branch(GO:0044307)
0.5 5.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.4 4.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.4 9.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.4 8.4 GO:0097342 ripoptosome(GO:0097342)
0.4 15.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 3.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.4 15.0 GO:0000795 synaptonemal complex(GO:0000795)
0.4 45.8 GO:0005796 Golgi lumen(GO:0005796)
0.3 7.2 GO:0005682 U5 snRNP(GO:0005682)
0.3 3.7 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 63.0 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 22.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 18.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 1.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 2.8 GO:0031298 replication fork protection complex(GO:0031298)
0.3 37.1 GO:0031985 Golgi cisterna(GO:0031985)
0.3 2.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.3 31.0 GO:0005604 basement membrane(GO:0005604)
0.3 3.4 GO:0071438 invadopodium membrane(GO:0071438)
0.3 24.8 GO:0005811 lipid particle(GO:0005811)
0.3 8.9 GO:0005795 Golgi stack(GO:0005795)
0.3 23.8 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 25.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.2 9.6 GO:0005771 multivesicular body(GO:0005771)
0.2 12.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 4.9 GO:0071564 npBAF complex(GO:0071564)
0.1 5.7 GO:0099738 cell cortex region(GO:0099738)
0.1 4.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 6.7 GO:0015030 Cajal body(GO:0015030)
0.1 16.9 GO:0043679 axon terminus(GO:0043679)
0.1 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 15.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 2.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 10.5 GO:0000922 spindle pole(GO:0000922)
0.1 10.1 GO:0005923 bicellular tight junction(GO:0005923)
0.1 43.8 GO:0005925 focal adhesion(GO:0005925)
0.1 0.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 8.9 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 3.6 GO:0005882 intermediate filament(GO:0005882)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 12.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 53.4 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
6.1 18.3 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
6.0 18.1 GO:0034512 box C/D snoRNA binding(GO:0034512)
4.5 13.5 GO:0070538 oleic acid binding(GO:0070538)
4.5 13.4 GO:0001069 regulatory region RNA binding(GO:0001069)
4.0 23.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
4.0 19.9 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
3.8 15.2 GO:0070404 NADH binding(GO:0070404)
3.7 22.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
3.6 10.8 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
3.6 17.8 GO:0042296 ISG15 transferase activity(GO:0042296)
3.5 28.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
3.0 12.0 GO:0047685 amine sulfotransferase activity(GO:0047685)
2.3 16.1 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
2.2 15.6 GO:0050815 phosphoserine binding(GO:0050815)
2.0 25.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.8 7.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
1.7 38.1 GO:0008494 translation activator activity(GO:0008494)
1.7 5.0 GO:0004750 ribulose-phosphate 3-epimerase activity(GO:0004750)
1.4 51.6 GO:0005540 hyaluronic acid binding(GO:0005540)
1.2 23.0 GO:0008432 JUN kinase binding(GO:0008432)
1.2 3.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.1 5.6 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
1.0 10.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
1.0 6.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
1.0 6.0 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.0 17.4 GO:0097016 L27 domain binding(GO:0097016)
0.9 4.7 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.8 3.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.7 20.0 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.7 12.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.7 12.1 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.6 26.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.6 9.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.6 9.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.6 18.6 GO:0070034 telomerase RNA binding(GO:0070034)
0.6 15.9 GO:0048156 tau protein binding(GO:0048156)
0.6 11.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.6 19.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.6 1.7 GO:0045550 geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.6 28.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.6 16.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 11.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.6 6.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.5 12.6 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.5 25.2 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.5 3.4 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.5 2.8 GO:0008420 CTD phosphatase activity(GO:0008420)
0.4 9.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.4 11.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 11.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.4 19.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.4 5.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.4 15.7 GO:0031369 translation initiation factor binding(GO:0031369)
0.4 28.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 16.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.3 5.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 5.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 9.7 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.3 83.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3 8.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.3 1.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.3 0.9 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.3 1.9 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.3 28.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 4.4 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 5.1 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.2 5.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 26.1 GO:0030165 PDZ domain binding(GO:0030165)
0.2 4.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.2 1.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 5.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 15.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 1.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 15.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 2.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 4.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 25.3 GO:0047485 protein N-terminus binding(GO:0047485)
0.2 10.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 8.9 GO:0030276 clathrin binding(GO:0030276)
0.1 3.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 6.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 3.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 46.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 3.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 2.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 8.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 14.9 GO:0004386 helicase activity(GO:0004386)
0.1 2.7 GO:0070403 NAD+ binding(GO:0070403)
0.1 15.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 7.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 1.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 29.3 GO:0003924 GTPase activity(GO:0003924)
0.1 1.1 GO:0031701 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.1 1.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 21.3 GO:0016887 ATPase activity(GO:0016887)
0.1 4.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.7 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 8.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 2.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 4.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.4 GO:0002020 protease binding(GO:0002020)
0.0 2.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.0 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 28.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
1.3 44.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.9 72.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.6 30.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 12.6 PID ARF 3PATHWAY Arf1 pathway
0.3 21.5 PID RHOA PATHWAY RhoA signaling pathway
0.3 25.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.3 29.4 PID CDC42 PATHWAY CDC42 signaling events
0.3 15.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.2 8.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 5.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 8.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.2 10.8 PID ARF6 PATHWAY Arf6 signaling events
0.2 18.8 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.2 12.7 PID PLK1 PATHWAY PLK1 signaling events
0.2 18.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 5.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 19.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 16.7 PID CMYB PATHWAY C-MYB transcription factor network
0.2 5.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 9.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 4.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 17.1 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 11.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.2 PID INSULIN PATHWAY Insulin Pathway
0.1 3.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.1 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 1.8 ST ADRENERGIC Adrenergic Pathway
0.1 9.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 46.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.4 24.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
1.3 53.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
1.2 18.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
1.1 28.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
1.1 38.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
1.1 106.1 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.8 23.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.7 25.5 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.7 21.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.6 17.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.6 1.9 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.6 16.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.6 12.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.6 22.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.5 12.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.5 17.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.5 5.7 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.4 20.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 14.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 9.0 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.4 12.6 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.3 16.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 10.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 52.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 15.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 8.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 13.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.2 15.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 4.5 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 3.6 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 6.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 3.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.2 6.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.9 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.1 11.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 20.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 6.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.8 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 3.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 7.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 7.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 9.7 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 1.6 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.7 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 0.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 2.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 2.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor