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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX2-3

Z-value: 3.31

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Transcription factors associated with NKX2-3

Gene Symbol Gene ID Gene Info
NKX2-3
ENSG00000119919.11 NKX2-3

Activity profile of NKX2-3 motif

Sorted Z-values of NKX2-3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_151025343 46.95 ENST00000521632.1
GPX3
glutathione peroxidase 3
chr5_+_151020438 16.04 ENST00000622181.4
ENST00000614343.4
ENST00000388825.9
ENST00000521650.5
ENST00000517973.1
GPX3
glutathione peroxidase 3
chr13_-_44474296 13.36 ENST00000611198.4
TSC22D1
TSC22 domain family member 1
chr19_+_44905785 10.81 ENST00000446996.5
ENST00000252486.9
ENST00000434152.5
APOE
apolipoprotein E
chr3_+_98763331 10.31 ENST00000485391.5
ENST00000492254.5
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr5_+_140834230 9.93 ENST00000356878.5
ENST00000525929.2
PCDHA7
protocadherin alpha 7
chr9_+_127612222 9.78 ENST00000637953.1
ENST00000636962.2
STXBP1
syntaxin binding protein 1
chr4_+_75514455 9.78 ENST00000508105.5
ENST00000311638.7
ENST00000380837.7
ENST00000507556.5
ENST00000504190.5
ENST00000507885.5
ENST00000502620.1
ENST00000514480.1
THAP6
THAP domain containing 6
chr14_-_21048431 9.53 ENST00000555026.5
NDRG2
NDRG family member 2
chr4_+_112818032 9.44 ENST00000672356.1
ENST00000672955.1
ANK2
ankyrin 2
chr4_+_112818088 9.39 ENST00000673044.1
ENST00000672696.1
ENST00000672315.1
ENST00000672088.1
ENST00000671793.1
ENST00000672402.1
ENST00000671825.1
ENST00000672312.1
ENST00000672830.1
ENST00000672731.1
ENST00000671854.1
ENST00000672350.1
ENST00000672684.1
ENST00000672934.1
ENST00000673546.1
ENST00000673573.1
ENST00000503423.6
ENST00000673255.1
ENST00000671893.1
ENST00000672246.1
ENST00000672930.1
ENST00000673334.1
ENST00000673453.1
ENST00000673555.1
ENST00000672880.1
ENST00000672990.1
ENST00000673430.1
ENST00000673298.1
ENST00000672068.1
ENST00000672362.1
ENST00000672793.1
ENST00000672209.1
ENST00000671756.1
ENST00000671809.1
ENST00000671906.1
ENST00000672090.1
ENST00000672177.1
ENST00000672759.1
ENST00000672965.1
ENST00000673109.1
ENST00000503271.5
ENST00000506722.5
ENST00000673536.1
ENST00000672986.1
ANK2
ankyrin 2
chr4_+_25160631 9.26 ENST00000510415.1
ENST00000507794.2
ENST00000512921.4
SEPSECS-AS1
PI4K2B
SEPSECS antisense RNA 1 (head to head)
phosphatidylinositol 4-kinase type 2 beta
chr9_+_128203371 8.37 ENST00000475805.5
ENST00000372923.8
ENST00000341179.11
ENST00000393594.7
DNM1
dynamin 1
chr11_+_10305065 7.56 ENST00000534464.1
ENST00000278175.10
ENST00000530439.1
ENST00000524948.5
ENST00000528655.5
ENST00000526492.4
ENST00000525063.2
ADM
adrenomedullin
chr9_-_113340248 7.43 ENST00000341761.8
ENST00000374195.7
ENST00000374193.9
WDR31
WD repeat domain 31
chr4_+_112860981 7.40 ENST00000671704.1
ANK2
ankyrin 2
chr4_-_46909235 7.05 ENST00000505102.1
ENST00000355591.8
COX7B2
cytochrome c oxidase subunit 7B2
chr4_-_46909206 6.95 ENST00000396533.5
COX7B2
cytochrome c oxidase subunit 7B2
chr4_+_112861053 6.80 ENST00000672221.1
ANK2
ankyrin 2
chr18_-_49460630 6.71 ENST00000675505.1
ENST00000442713.6
ENST00000269445.10
DYM
dymeclin
chr4_-_99352754 6.67 ENST00000639454.1
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr20_-_4815100 6.43 ENST00000379376.2
RASSF2
Ras association domain family member 2
chr2_-_2326210 6.27 ENST00000647755.1
MYT1L
myelin transcription factor 1 like
chr14_-_90331904 6.09 ENST00000628832.1
ENST00000354366.8
NRDE2
NRDE-2, necessary for RNA interference, domain containing
chr10_-_15371225 5.74 ENST00000378116.9
FAM171A1
family with sequence similarity 171 member A1
chr5_+_36608146 5.74 ENST00000381918.4
ENST00000513646.1
SLC1A3
solute carrier family 1 member 3
chr4_-_89836963 5.47 ENST00000420646.6
ENST00000673718.1
SNCA
synuclein alpha
chr22_+_38057371 5.43 ENST00000437453.5
ENST00000356976.8
PICK1
protein interacting with PRKCA 1
chrX_+_115561162 5.40 ENST00000355899.8
ENST00000626746.2
ENST00000289290.7
PLS3
plastin 3
chr3_-_122416035 5.30 ENST00000330689.6
WDR5B
WD repeat domain 5B
chr13_-_49444004 5.19 ENST00000410043.5
ENST00000409308.6
CAB39L
calcium binding protein 39 like
chr6_+_69232406 5.03 ENST00000238918.12
ADGRB3
adhesion G protein-coupled receptor B3
chr17_+_44186953 5.02 ENST00000446571.7
ENST00000538716.7
ENST00000357984.7
TMUB2
transmembrane and ubiquitin like domain containing 2
chr7_-_77199808 4.94 ENST00000248598.6
FGL2
fibrinogen like 2
chr1_-_34859717 4.92 ENST00000423898.1
ENST00000521580.3
ENST00000456842.1
SMIM12
small integral membrane protein 12
chr4_-_89836213 4.74 ENST00000618500.4
ENST00000508895.5
SNCA
synuclein alpha
chr4_-_89837106 4.73 ENST00000394986.5
ENST00000394991.8
ENST00000506244.5
ENST00000394989.6
ENST00000673902.1
ENST00000674129.1
SNCA
synuclein alpha
chr2_-_2326378 4.66 ENST00000647618.1
MYT1L
myelin transcription factor 1 like
chr1_+_156591741 4.44 ENST00000368234.7
ENST00000680087.1
ENST00000681734.1
ENST00000679369.1
ENST00000680269.1
ENST00000680661.1
ENST00000681054.1
ENST00000680004.1
ENST00000679702.1
ENST00000368235.8
ENST00000368233.3
NAXE
NAD(P)HX epimerase
chr17_+_55267584 4.25 ENST00000575345.5
HLF
HLF transcription factor, PAR bZIP family member
chr6_-_11382247 4.24 ENST00000397378.7
ENST00000513989.5
ENST00000508546.5
ENST00000504387.5
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr2_-_38076076 4.21 ENST00000614273.1
ENST00000610745.5
ENST00000490576.1
CYP1B1
cytochrome P450 family 1 subfamily B member 1
chr6_-_33317728 4.03 ENST00000431845.3
ZBTB22
zinc finger and BTB domain containing 22
chr2_-_36598140 3.95 ENST00000405912.8
ENST00000379245.8
FEZ2
fasciculation and elongation protein zeta 2
chr3_+_186842687 3.86 ENST00000444204.2
ENST00000320741.7
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr9_-_111036207 3.84 ENST00000541779.5
LPAR1
lysophosphatidic acid receptor 1
chr12_+_123233420 3.80 ENST00000253233.6
ENST00000366329.7
ENST00000546132.2
ENST00000536130.2
C12orf65
chromosome 12 open reading frame 65
chr18_-_66604076 3.78 ENST00000540086.5
ENST00000580157.2
ENST00000262150.7
CDH19
cadherin 19
chr4_-_99321362 3.76 ENST00000625860.2
ENST00000305046.13
ENST00000506651.5
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr3_+_121567924 3.75 ENST00000334384.5
ARGFX
arginine-fifty homeobox
chr12_+_14419136 3.70 ENST00000545769.1
ENST00000428217.6
ENST00000396279.2
ENST00000542514.5
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr1_+_202348687 3.64 ENST00000608999.6
ENST00000391959.5
ENST00000480184.5
PPP1R12B
protein phosphatase 1 regulatory subunit 12B
chr1_-_79006773 3.64 ENST00000671209.1
ADGRL4
adhesion G protein-coupled receptor L4
chr22_-_43862480 3.63 ENST00000330884.9
SULT4A1
sulfotransferase family 4A member 1
chr7_-_151277407 3.61 ENST00000392811.6
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr4_-_99352730 3.60 ENST00000510055.5
ENST00000515683.6
ENST00000511397.3
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr17_-_78874038 3.57 ENST00000586057.5
TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_79006680 3.53 ENST00000370742.4
ENST00000656841.1
ADGRL4
adhesion G protein-coupled receptor L4
chr6_-_11779606 3.50 ENST00000506810.1
ADTRP
androgen dependent TFPI regulating protein
chr3_-_39051935 3.47 ENST00000668754.1
ENST00000302328.9
SCN11A
sodium voltage-gated channel alpha subunit 11
chr12_-_49897056 3.41 ENST00000552863.5
FAIM2
Fas apoptotic inhibitory molecule 2
chr8_+_133113483 3.39 ENST00000521107.1
TG
thyroglobulin
chr3_-_120742506 3.31 ENST00000273375.8
ENST00000483733.1
RABL3
RAB, member of RAS oncogene family like 3
chr17_-_8152380 3.29 ENST00000317276.9
PER1
period circadian regulator 1
chr12_+_101594849 3.29 ENST00000547405.5
ENST00000452455.6
ENST00000392934.7
ENST00000547509.5
ENST00000361685.6
ENST00000549145.5
ENST00000361466.7
ENST00000553190.5
ENST00000545503.6
ENST00000536007.5
ENST00000541119.5
ENST00000551300.5
ENST00000550270.1
MYBPC1
myosin binding protein C1
chr18_+_58362467 3.25 ENST00000675101.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr11_-_102798148 3.18 ENST00000315274.7
MMP1
matrix metallopeptidase 1
chr22_+_24806265 3.12 ENST00000400359.4
SGSM1
small G protein signaling modulator 1
chr17_-_78874140 3.11 ENST00000585421.5
TIMP2
TIMP metallopeptidase inhibitor 2
chr7_-_120858066 3.10 ENST00000222747.8
TSPAN12
tetraspanin 12
chr16_-_3400963 3.08 ENST00000571906.1
ENST00000573830.1
ENST00000439568.2
ENST00000396852.9
ENST00000422427.6
ENST00000304926.7
ENST00000618425.4
ENST00000396846.8
ZSCAN32
zinc finger and SCAN domain containing 32
chr10_-_68332914 3.04 ENST00000358769.7
ENST00000495025.2
PBLD
phenazine biosynthesis like protein domain containing
chr6_-_33271835 3.01 ENST00000482399.5
ENST00000445902.3
VPS52
VPS52 subunit of GARP complex
chr3_-_42875871 2.99 ENST00000316161.6
ENST00000437102.1
CYP8B1
cytochrome P450 family 8 subfamily B member 1
chr17_+_60149966 2.84 ENST00000300900.9
CA4
carbonic anhydrase 4
chr22_+_38057200 2.82 ENST00000404072.7
ENST00000424694.5
PICK1
protein interacting with PRKCA 1
chr4_+_94455245 2.82 ENST00000508216.5
ENST00000514743.5
PDLIM5
PDZ and LIM domain 5
chr1_+_196819731 2.75 ENST00000320493.10
ENST00000367424.4
CFHR1
complement factor H related 1
chr3_-_51968387 2.74 ENST00000490063.5
ENST00000468324.5
ENST00000497653.5
ENST00000484633.5
PCBP4
poly(rC) binding protein 4
chr12_-_47725483 2.69 ENST00000422538.8
ENDOU
endonuclease, poly(U) specific
chr22_+_24806169 2.65 ENST00000610372.4
ENST00000400358.9
SGSM1
small G protein signaling modulator 1
chr9_-_134917872 2.65 ENST00000616356.4
ENST00000371806.4
FCN1
ficolin 1
chr1_-_182604379 2.62 ENST00000367558.6
RGS16
regulator of G protein signaling 16
chr12_-_112382363 2.60 ENST00000682272.1
ENST00000377560.9
HECTD4
HECT domain E3 ubiquitin protein ligase 4
chr2_-_187554473 2.55 ENST00000453013.5
ENST00000417013.5
TFPI
tissue factor pathway inhibitor
chr1_+_46340780 2.46 ENST00000474844.6
NSUN4
NOP2/Sun RNA methyltransferase 4
chr3_+_155083523 2.42 ENST00000680057.1
MME
membrane metalloendopeptidase
chr19_-_51002527 2.37 ENST00000595238.1
ENST00000600767.5
KLK8
kallikrein related peptidase 8
chr19_-_14776756 2.33 ENST00000596991.6
ENST00000594294.5
ENST00000594076.5
ENST00000595839.5
ENST00000392965.7
ENST00000601345.5
ADGRE2
adhesion G protein-coupled receptor E2
chr6_+_72366730 2.32 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr12_+_8822610 2.32 ENST00000299698.12
A2ML1
alpha-2-macroglobulin like 1
chr4_+_94974984 2.30 ENST00000672698.1
BMPR1B
bone morphogenetic protein receptor type 1B
chr8_-_27478851 2.29 ENST00000240132.7
CHRNA2
cholinergic receptor nicotinic alpha 2 subunit
chr4_+_87832917 2.25 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr12_-_124914108 2.21 ENST00000541645.1
ENST00000540351.1
UBC
ubiquitin C
chr14_-_67412112 2.21 ENST00000216446.9
PLEK2
pleckstrin 2
chrX_-_107118783 2.21 ENST00000372487.5
ENST00000372479.7
RBM41
RNA binding motif protein 41
chr10_+_97572771 2.17 ENST00000370655.6
ENST00000455090.1
ANKRD2
ankyrin repeat domain 2
chr8_-_17697654 2.15 ENST00000297488.10
MTUS1
microtubule associated scaffold protein 1
chr17_-_31314066 2.12 ENST00000577894.1
EVI2B
ecotropic viral integration site 2B
chr12_-_121858849 2.11 ENST00000289004.8
HPD
4-hydroxyphenylpyruvate dioxygenase
chr10_+_17752185 2.11 ENST00000377495.2
TMEM236
transmembrane protein 236
chr17_+_28335718 2.10 ENST00000226225.7
TNFAIP1
TNF alpha induced protein 1
chr10_-_48605032 2.08 ENST00000249601.9
ARHGAP22
Rho GTPase activating protein 22
chr18_+_45615473 2.07 ENST00000255226.11
SLC14A2
solute carrier family 14 member 2
chr4_-_36244438 2.04 ENST00000303965.9
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr19_+_39125769 1.99 ENST00000602004.1
ENST00000599470.5
ENST00000321944.8
ENST00000593480.5
ENST00000358301.7
ENST00000593690.5
ENST00000599386.5
PAK4
p21 (RAC1) activated kinase 4
chr14_-_92748570 1.97 ENST00000553918.1
ENST00000555699.5
ENST00000334869.9
ENST00000553802.5
ENST00000554397.5
ENST00000554919.5
ENST00000554080.5
ENST00000553371.1
ENST00000557434.5
ENST00000393218.6
LGMN
legumain
chrX_+_153764178 1.97 ENST00000538966.5
PLXNB3
plexin B3
chr6_+_31587002 1.93 ENST00000376090.6
LST1
leukocyte specific transcript 1
chr17_+_28335571 1.93 ENST00000544907.6
TNFAIP1
TNF alpha induced protein 1
chrX_-_109733181 1.91 ENST00000673016.1
ACSL4
acyl-CoA synthetase long chain family member 4
chr17_-_4641670 1.90 ENST00000293761.8
ALOX15
arachidonate 15-lipoxygenase
chr20_-_45101112 1.90 ENST00000306117.5
ENST00000537075.3
KCNS1
potassium voltage-gated channel modifier subfamily S member 1
chr12_-_121580954 1.89 ENST00000536437.5
ENST00000611216.4
ENST00000538046.6
ENST00000377071.9
KDM2B
lysine demethylase 2B
chr11_+_72135718 1.89 ENST00000611028.3
ENST00000546166.1
ENST00000442948.3
FOLR3
folate receptor gamma
chr12_-_124914304 1.87 ENST00000535859.1
ENST00000546271.1
ENST00000540700.1
ENST00000546120.2
ENST00000339647.6
UBC
ubiquitin C
chr15_+_58410543 1.86 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chr10_+_97572493 1.86 ENST00000307518.9
ENST00000298808.9
ANKRD2
ankyrin repeat domain 2
chr2_+_200305873 1.84 ENST00000439084.5
ENST00000409718.5
SPATS2L
spermatogenesis associated serine rich 2 like
chr11_-_56292254 1.82 ENST00000641600.1
OR8H1
olfactory receptor family 8 subfamily H member 1
chr11_+_65386611 1.78 ENST00000531296.1
ENST00000533782.5
ENST00000355991.9
ENST00000317568.10
ENST00000416776.6
ENST00000526201.1
FRMD8
FERM domain containing 8
chr14_-_91253925 1.76 ENST00000531499.2
GPR68
G protein-coupled receptor 68
chr12_+_49367490 1.76 ENST00000551540.5
ENST00000548777.5
ENST00000547865.5
ENST00000552171.1
SPATS2
spermatogenesis associated serine rich 2
chr4_-_99290975 1.75 ENST00000209668.3
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr16_-_30123203 1.72 ENST00000395202.5
ENST00000395199.7
ENST00000263025.9
ENST00000322266.9
MAPK3
mitogen-activated protein kinase 3
chr12_-_119877270 1.72 ENST00000261833.11
ENST00000612548.4
CIT
citron rho-interacting serine/threonine kinase
chr4_+_143381939 1.72 ENST00000505913.5
GAB1
GRB2 associated binding protein 1
chr5_+_150190035 1.70 ENST00000230671.7
ENST00000524041.1
SLC6A7
solute carrier family 6 member 7
chr3_-_111595339 1.68 ENST00000317012.5
ZBED2
zinc finger BED-type containing 2
chr6_-_151452096 1.67 ENST00000444024.3
ENST00000682641.1
ENST00000682299.1
ENST00000622845.5
RMND1
required for meiotic nuclear division 1 homolog
chr8_+_74350394 1.67 ENST00000675928.1
ENST00000676443.1
ENST00000676112.1
ENST00000674710.1
ENST00000434412.3
ENST00000675165.1
ENST00000674973.1
ENST00000220822.12
ENST00000675999.1
ENST00000523640.2
ENST00000524195.2
ENST00000675463.1
ENST00000676207.1
ENST00000674865.1
ENST00000676415.1
GDAP1
ganglioside induced differentiation associated protein 1
chr3_+_155083889 1.66 ENST00000680282.1
MME
membrane metalloendopeptidase
chr6_+_31586859 1.65 ENST00000433492.5
LST1
leukocyte specific transcript 1
chr18_+_63777773 1.64 ENST00000447428.5
ENST00000546027.5
SERPINB7
serpin family B member 7
chr12_-_47725558 1.64 ENST00000229003.7
ENDOU
endonuclease, poly(U) specific
chr1_+_196943738 1.62 ENST00000367415.8
ENST00000367421.5
ENST00000649283.1
ENST00000476712.6
ENST00000496448.6
ENST00000473386.1
ENST00000649960.1
CFHR2
complement factor H related 2
chr7_-_87713287 1.62 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ABCB1
ATP binding cassette subfamily B member 1
chr2_-_24047348 1.62 ENST00000406895.3
WDCP
WD repeat and coiled coil containing
chr7_+_134745460 1.61 ENST00000436461.6
CALD1
caldesmon 1
chr6_-_137219028 1.56 ENST00000647124.1
ENST00000642390.1
ENST00000645753.1
ENST00000646036.1
ENST00000646898.1
ENST00000644894.1
IFNGR1
interferon gamma receptor 1
chr19_-_38878247 1.56 ENST00000591812.2
RINL
Ras and Rab interactor like
chr2_+_137964446 1.56 ENST00000280096.5
ENST00000280097.5
HNMT
histamine N-methyltransferase
chrX_+_153764233 1.54 ENST00000361971.10
PLXNB3
plexin B3
chr16_-_66918839 1.53 ENST00000565235.2
ENST00000568632.5
ENST00000565796.5
CDH16
cadherin 16
chr14_+_20955484 1.52 ENST00000304625.3
RNASE2
ribonuclease A family member 2
chr16_-_66918876 1.52 ENST00000570262.5
ENST00000299752.9
ENST00000394055.7
CDH16
cadherin 16
chr6_+_31586680 1.50 ENST00000339530.8
LST1
leukocyte specific transcript 1
chr3_-_69013612 1.44 ENST00000295571.9
EOGT
EGF domain specific O-linked N-acetylglucosamine transferase
chr19_-_15808126 1.42 ENST00000334920.3
OR10H1
olfactory receptor family 10 subfamily H member 1
chr2_-_24047375 1.41 ENST00000295148.9
WDCP
WD repeat and coiled coil containing
chrX_-_21758021 1.40 ENST00000646008.1
SMPX
small muscle protein X-linked
chr19_-_14778552 1.40 ENST00000315576.8
ADGRE2
adhesion G protein-coupled receptor E2
chr15_+_69160620 1.39 ENST00000261858.7
GLCE
glucuronic acid epimerase
chr14_+_39233908 1.33 ENST00000280082.4
MIA2
MIA SH3 domain ER export factor 2
chr4_-_67883987 1.31 ENST00000283916.11
TMPRSS11D
transmembrane serine protease 11D
chrX_-_109733220 1.28 ENST00000672282.1
ENST00000340800.7
ACSL4
acyl-CoA synthetase long chain family member 4
chr12_-_122703346 1.28 ENST00000328880.6
HCAR2
hydroxycarboxylic acid receptor 2
chr16_-_30122944 1.27 ENST00000484663.5
ENST00000478356.5
MAPK3
mitogen-activated protein kinase 3
chr17_+_77405070 1.25 ENST00000585930.5
SEPTIN9
septin 9
chr7_-_80919017 1.22 ENST00000265361.8
SEMA3C
semaphorin 3C
chr8_+_103298433 1.22 ENST00000522566.5
FZD6
frizzled class receptor 6
chr4_-_39032343 1.21 ENST00000381938.4
TMEM156
transmembrane protein 156
chr6_+_28349907 1.21 ENST00000252211.7
ENST00000341464.9
ENST00000377255.3
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr4_-_75514387 1.20 ENST00000324439.10
ENST00000512706.5
RCHY1
ring finger and CHY zinc finger domain containing 1
chr6_+_31586835 1.20 ENST00000211921.11
LST1
leukocyte specific transcript 1
chr5_-_115841548 1.19 ENST00000509910.2
ENST00000500945.2
ATG12
autophagy related 12
chr11_+_28110275 1.19 ENST00000303459.10
ENST00000634762.1
ENST00000634721.1
METTL15
methyltransferase like 15
chr8_-_98942557 1.16 ENST00000523601.5
STK3
serine/threonine kinase 3
chr6_+_167999092 1.16 ENST00000443060.6
KIF25
kinesin family member 25
chr18_+_24460655 1.15 ENST00000426880.2
HRH4
histamine receptor H4
chr9_-_92404559 1.15 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr19_-_10231293 1.14 ENST00000646641.1
S1PR2
sphingosine-1-phosphate receptor 2
chr6_+_82363199 1.14 ENST00000535040.4
TPBG
trophoblast glycoprotein
chr10_+_99659430 1.14 ENST00000370489.5
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr6_+_31586269 1.13 ENST00000438075.7
LST1
leukocyte specific transcript 1
chr12_+_56996151 1.12 ENST00000556850.1
GPR182
G protein-coupled receptor 182
chr15_-_89893963 1.11 ENST00000560940.5
ENST00000336418.9
ENST00000558011.5
AP3S2
adaptor related protein complex 3 subunit sigma 2
chr12_+_19205294 1.09 ENST00000424268.5
PLEKHA5
pleckstrin homology domain containing A5
chr11_+_99021066 1.08 ENST00000527185.5
ENST00000528682.5
CNTN5
contactin 5
chr11_+_61248122 1.08 ENST00000451616.6
PGA5
pepsinogen A5
chr11_+_12674397 1.07 ENST00000527636.7
TEAD1
TEA domain transcription factor 1
chr2_-_178108339 1.07 ENST00000358450.8
PDE11A
phosphodiesterase 11A
chr5_+_108747879 1.07 ENST00000281092.9
FER
FER tyrosine kinase
chr10_-_77637789 1.07 ENST00000481070.1
ENST00000640969.1
ENST00000286628.14
ENST00000638991.1
ENST00000639913.1
ENST00000480683.2
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr3_-_49723903 1.06 ENST00000678010.1
ENST00000480687.5
ENST00000308388.7
ENST00000308375.10
ENST00000677393.1
ENST00000495627.2
GMPPB
GDP-mannose pyrophosphorylase B
chr12_-_122716790 1.04 ENST00000528880.3
HCAR3
hydroxycarboxylic acid receptor 3
chr14_+_22479521 1.03 ENST00000390483.1
TRAJ56
T cell receptor alpha joining 56
chr1_+_34755039 1.02 ENST00000338513.1
GJB5
gap junction protein beta 5
chr17_+_81977539 1.00 ENST00000306729.11
ASPSCR1
ASPSCR1 tether for SLC2A4, UBX domain containing
chr3_-_115071333 1.00 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_144008396 1.00 ENST00000354765.6
ENST00000416623.5
ENST00000649211.1
PLAGL1
PLAG1 like zinc finger 1
chr19_-_18941184 0.99 ENST00000594794.5
ENST00000392351.8
ENST00000596482.5
HOMER3
homer scaffold protein 3
chr14_+_19743571 0.99 ENST00000642117.2
OR4Q3
olfactory receptor family 4 subfamily Q member 3
chr1_+_206897435 0.95 ENST00000391929.7
ENST00000294984.7
ENST00000611909.4
ENST00000367093.3
IL24
interleukin 24
chrX_+_30235894 0.94 ENST00000620842.1
MAGEB3
MAGE family member B3
chr16_-_10559135 0.93 ENST00000536829.1
EMP2
epithelial membrane protein 2
chr13_+_48653921 0.93 ENST00000682523.1
CYSLTR2
cysteinyl leukotriene receptor 2
chr18_-_28036585 0.92 ENST00000399380.7
CDH2
cadherin 2
chr6_-_46080332 0.92 ENST00000185206.12
CLIC5
chloride intracellular channel 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
21.0 63.0 GO:0006982 response to lipid hydroperoxide(GO:0006982)
3.3 33.0 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.8 8.4 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
2.4 9.8 GO:1903296 regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
2.3 14.1 GO:0051945 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
2.2 10.8 GO:1901628 NMDA glutamate receptor clustering(GO:0097114) positive regulation of postsynaptic membrane organization(GO:1901628) positive regulation of dendritic spine maintenance(GO:1902952)
1.5 7.6 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
1.4 4.2 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
1.3 15.8 GO:0006069 ethanol oxidation(GO:0006069)
1.3 3.9 GO:2000584 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
1.3 5.0 GO:0099558 maintenance of synapse structure(GO:0099558)
1.1 6.7 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
1.0 8.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
1.0 3.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.9 2.6 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.8 3.8 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.7 3.6 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.7 4.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.7 3.3 GO:0097167 circadian regulation of translation(GO:0097167)
0.7 11.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.6 1.9 GO:2001303 cellular response to interleukin-13(GO:0035963) regulation of engulfment of apoptotic cell(GO:1901074) lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.6 1.9 GO:0021592 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
0.6 5.7 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.5 2.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.5 3.0 GO:0000189 MAPK import into nucleus(GO:0000189)
0.5 6.4 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.5 4.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.4 4.0 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.4 3.4 GO:0015705 iodide transport(GO:0015705)
0.4 3.8 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.4 1.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.4 2.3 GO:1902731 negative regulation of chondrocyte proliferation(GO:1902731)
0.4 1.1 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.4 3.5 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.3 10.3 GO:0097503 sialylation(GO:0097503)
0.3 3.4 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.3 4.4 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.3 1.2 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.3 11.6 GO:0048665 neuron fate specification(GO:0048665)
0.3 1.8 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.3 2.3 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.3 4.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.3 3.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.3 1.1 GO:0038109 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.3 2.4 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.3 1.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.3 2.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.3 1.6 GO:0001692 histamine metabolic process(GO:0001692) histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.3 1.3 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.3 1.0 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.2 0.7 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.2 3.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 4.9 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.2 1.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.2 3.0 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 3.4 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.2 4.0 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.2 1.7 GO:0035524 proline transmembrane transport(GO:0035524)
0.2 5.9 GO:0016246 RNA interference(GO:0016246)
0.2 0.8 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.2 0.8 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.2 2.5 GO:0031642 negative regulation of myelination(GO:0031642)
0.2 0.9 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.2 0.6 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.2 0.9 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.2 0.6 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 2.3 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 0.3 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.1 1.9 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 1.1 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.1 1.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 1.2 GO:0070475 rRNA base methylation(GO:0070475)
0.1 10.4 GO:0009988 cell-cell recognition(GO:0009988)
0.1 3.6 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 0.2 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 4.0 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 1.9 GO:0015884 folic acid transport(GO:0015884)
0.1 1.2 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.1 1.4 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 9.8 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 0.9 GO:0070836 caveola assembly(GO:0070836)
0.1 3.1 GO:0010842 retina layer formation(GO:0010842)
0.1 0.5 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.9 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.4 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.1 3.2 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.1 3.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.7 GO:0051552 coumarin metabolic process(GO:0009804) flavone metabolic process(GO:0051552)
0.1 1.1 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 0.6 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 14.3 GO:0007030 Golgi organization(GO:0007030)
0.1 1.7 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.1 2.8 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.8 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 3.7 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.1 0.7 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.9 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.1 1.9 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 2.0 GO:0042359 vitamin D metabolic process(GO:0042359)
0.1 0.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.7 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.1 0.7 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 1.1 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.7 GO:0071305 cellular response to vitamin D(GO:0071305)
0.1 1.7 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.1 3.5 GO:0051931 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.1 3.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 5.7 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.1 0.8 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 4.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 2.8 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 1.1 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.2 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.3 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 0.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 1.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.9 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 2.2 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 1.2 GO:0044804 nucleophagy(GO:0044804)
0.0 4.1 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 3.3 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.9 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.8 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.5 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.7 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 1.3 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 2.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)
0.0 3.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 4.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.2 GO:0019255 UDP-glucuronate biosynthetic process(GO:0006065) glucose 1-phosphate metabolic process(GO:0019255) UDP-glucuronate metabolic process(GO:0046398)
0.0 0.6 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 1.4 GO:0035094 response to nicotine(GO:0035094)
0.0 1.1 GO:0035329 hippo signaling(GO:0035329)
0.0 4.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 2.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:1904640 response to methionine(GO:1904640)
0.0 0.1 GO:0019082 viral protein processing(GO:0019082) negative regulation of neurotrophin production(GO:0032900) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 1.4 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 3.7 GO:0060348 bone development(GO:0060348)
0.0 0.1 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.0 0.3 GO:0032098 regulation of appetite(GO:0032098)
0.0 2.7 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 0.5 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 1.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 2.0 GO:0060996 dendritic spine development(GO:0060996)
0.0 2.6 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 1.5 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 3.0 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.6 9.8 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.9 14.0 GO:0045277 respiratory chain complex IV(GO:0045277)
0.6 38.3 GO:0031430 M band(GO:0031430)
0.4 2.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.4 3.0 GO:1990745 EARP complex(GO:1990745)
0.4 4.9 GO:0005577 fibrinogen complex(GO:0005577)
0.4 13.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 1.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.3 5.0 GO:0043083 synaptic cleft(GO:0043083)
0.3 2.0 GO:0036021 endolysosome lumen(GO:0036021)
0.3 0.8 GO:0098536 deuterosome(GO:0098536)
0.3 1.6 GO:0005594 collagen type IX trimer(GO:0005594)
0.2 1.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.2 2.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 8.2 GO:0016235 aggresome(GO:0016235)
0.1 7.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.1 3.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 4.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.7 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 2.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 3.5 GO:0031672 A band(GO:0031672)
0.1 3.3 GO:0031143 pseudopodium(GO:0031143)
0.1 4.5 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 8.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 1.1 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 1.6 GO:0030478 actin cap(GO:0030478)
0.1 3.6 GO:0071564 SWI/SNF complex(GO:0016514) npBAF complex(GO:0071564)
0.1 2.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 4.0 GO:0000791 euchromatin(GO:0000791)
0.1 0.5 GO:0002177 manchette(GO:0002177)
0.1 0.8 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 1.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 4.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.1 3.8 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.9 GO:0016342 fascia adherens(GO:0005916) catenin complex(GO:0016342)
0.1 0.7 GO:0016013 syntrophin complex(GO:0016013)
0.1 5.4 GO:0032432 actin filament bundle(GO:0032432)
0.1 5.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 9.2 GO:0030426 growth cone(GO:0030426)
0.0 6.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 83.2 GO:0005615 extracellular space(GO:0005615)
0.0 4.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0035102 PRC1 complex(GO:0035102)
0.0 4.2 GO:0005903 brush border(GO:0005903)
0.0 3.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 7.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.6 GO:0046930 pore complex(GO:0046930)
0.0 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 1.0 GO:0045178 basal part of cell(GO:0045178)
0.0 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 6.2 GO:0005938 cell cortex(GO:0005938)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 2.1 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 2.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 2.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 4.6 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 63.0 GO:0008430 selenium binding(GO:0008430)
3.4 10.3 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
2.7 10.8 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
2.3 14.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
2.0 15.8 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
1.5 9.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
1.3 4.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.0 8.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.9 3.7 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.9 3.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.8 3.8 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.8 2.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.6 1.9 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.6 6.5 GO:0033691 sialic acid binding(GO:0033691)
0.6 2.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.5 1.6 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.5 33.0 GO:0030507 spectrin binding(GO:0030507)
0.5 2.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.5 3.5 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.5 9.8 GO:0043274 phospholipase binding(GO:0043274)
0.5 3.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 5.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 1.6 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.4 3.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.3 1.7 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.3 9.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 7.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.5 GO:0004522 ribonuclease A activity(GO:0004522)
0.3 4.3 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 1.2 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 3.3 GO:0031432 titin binding(GO:0031432)
0.2 0.7 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.2 4.6 GO:0016854 racemase and epimerase activity(GO:0016854)
0.2 0.7 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.2 3.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 4.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 4.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 2.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.7 GO:0004969 histamine receptor activity(GO:0004969)
0.2 4.2 GO:0070330 aromatase activity(GO:0070330)
0.2 2.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 0.9 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 1.8 GO:0005549 odorant binding(GO:0005549)
0.2 3.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 4.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.6 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2 1.1 GO:0070568 guanylyltransferase activity(GO:0070568)
0.2 2.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 0.8 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 0.6 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.7 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 1.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 3.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 2.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 3.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.5 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 3.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 1.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 3.0 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.9 GO:0005542 folic acid binding(GO:0005542)
0.1 1.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 0.7 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 11.0 GO:0005179 hormone activity(GO:0005179)
0.1 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 13.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.0 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.5 GO:0046625 sphingolipid binding(GO:0046625)
0.1 0.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.2 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.1 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.0 6.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 1.4 GO:0042166 acetylcholine binding(GO:0042166)
0.0 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 14.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.5 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 4.9 GO:0002020 protease binding(GO:0002020)
0.0 1.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.5 GO:0032052 bile acid binding(GO:0032052)
0.0 3.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.7 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.7 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 16.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.0 GO:0016853 isomerase activity(GO:0016853)
0.0 1.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 3.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.8 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 1.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.3 17.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 3.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.1 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 4.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 4.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 7.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 4.6 PID FGF PATHWAY FGF signaling pathway
0.1 5.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.4 PID FAS PATHWAY FAS (CD95) signaling pathway
0.1 12.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 7.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.5 PID P73PATHWAY p73 transcription factor network
0.0 2.0 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.9 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID RHOA PATHWAY RhoA signaling pathway
0.0 7.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.0 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 2.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.3 PID BMP PATHWAY BMP receptor signaling
0.0 1.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.6 PID INSULIN PATHWAY Insulin Pathway
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 15.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.6 12.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.5 12.1 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.5 9.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.4 8.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.4 10.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.4 3.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 7.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.4 8.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 14.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 9.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 5.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.2 2.8 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 3.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.0 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 3.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 4.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 3.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 9.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.0 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.0 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.1 2.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 4.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.1 2.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.9 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 3.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.0 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 3.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 5.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 4.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells