Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX2-4
Z-value: 1.02
Motif logo
Transcription factors associated with NKX2-4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NKX2-4
|
ENSG00000125816.5 | NKX2-4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-4 | hg38_v1_chr20_-_21397513_21397531 | -0.17 | 1.1e-02 | Click! |
Activity profile of NKX2-4 motif
Sorted Z-values of NKX2-4 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.4 | GO:2000439 | positive regulation of monocyte extravasation(GO:2000439) |
| 1.0 | 2.9 | GO:0018160 | peptidyl-pyrromethane cofactor linkage(GO:0018160) |
| 0.9 | 8.2 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 0.8 | 2.5 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.8 | 2.5 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.8 | 5.6 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.8 | 4.7 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.8 | 3.1 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.8 | 4.6 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
| 0.7 | 3.6 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.6 | 4.4 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.5 | 3.7 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.5 | 2.1 | GO:0055014 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 0.5 | 2.3 | GO:1901662 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 0.5 | 1.4 | GO:1903015 | regulation of exo-alpha-sialidase activity(GO:1903015) |
| 0.4 | 1.8 | GO:1904640 | response to methionine(GO:1904640) |
| 0.4 | 1.3 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
| 0.4 | 1.5 | GO:0090579 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.4 | 1.8 | GO:0019323 | pentose catabolic process(GO:0019323) |
| 0.4 | 1.8 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.4 | 1.4 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.4 | 1.4 | GO:0032848 | negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.3 | 3.0 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.3 | 3.9 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.3 | 1.0 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
| 0.3 | 1.0 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.3 | 1.9 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.3 | 1.6 | GO:0006574 | valine catabolic process(GO:0006574) |
| 0.3 | 4.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.3 | 1.5 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.3 | 1.5 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.3 | 2.2 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.3 | 0.8 | GO:0048213 | Golgi vesicle prefusion complex stabilization(GO:0048213) |
| 0.3 | 0.8 | GO:0045645 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.3 | 1.6 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.3 | 0.8 | GO:0003095 | pressure natriuresis(GO:0003095) |
| 0.3 | 1.3 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.3 | 3.2 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.2 | 0.7 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.2 | 3.9 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.2 | 2.0 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.2 | 0.9 | GO:0030961 | peptidyl-arginine hydroxylation(GO:0030961) |
| 0.2 | 1.2 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.2 | 1.7 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.2 | 1.7 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.2 | 1.8 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.2 | 0.5 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.2 | 2.2 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.2 | 1.5 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.2 | 1.6 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 0.2 | 0.8 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.2 | 1.4 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.2 | 0.9 | GO:0097052 | L-kynurenine metabolic process(GO:0097052) |
| 0.2 | 2.3 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.1 | 0.6 | GO:0099543 | positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) synaptic vesicle targeting(GO:0016080) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) |
| 0.1 | 0.9 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.1 | 2.5 | GO:0043619 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619) |
| 0.1 | 1.7 | GO:0061366 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.1 | 0.6 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.1 | 0.4 | GO:1902161 | positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161) |
| 0.1 | 0.7 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 0.1 | 0.5 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.1 | 0.4 | GO:0002625 | regulation of T cell antigen processing and presentation(GO:0002625) |
| 0.1 | 0.5 | GO:0060523 | prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) |
| 0.1 | 0.5 | GO:1900133 | regulation of renin secretion into blood stream(GO:1900133) |
| 0.1 | 1.1 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 0.6 | GO:0060717 | chorion development(GO:0060717) |
| 0.1 | 1.6 | GO:0051775 | response to redox state(GO:0051775) |
| 0.1 | 1.5 | GO:0070129 | regulation of mitochondrial translation(GO:0070129) |
| 0.1 | 1.9 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.1 | 1.9 | GO:0075713 | establishment of integrated proviral latency(GO:0075713) |
| 0.1 | 0.3 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) |
| 0.1 | 1.3 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.1 | 0.6 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.1 | 1.2 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.1 | 0.7 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.1 | 0.8 | GO:0021830 | interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.1 | 9.8 | GO:0007127 | meiosis I(GO:0007127) |
| 0.1 | 1.4 | GO:0032808 | lacrimal gland development(GO:0032808) |
| 0.1 | 0.4 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529) |
| 0.1 | 0.4 | GO:2000213 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
| 0.1 | 0.8 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.1 | 0.8 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.1 | 0.8 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 1.0 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.1 | 0.5 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 1.1 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.1 | 1.6 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.1 | 1.6 | GO:0048757 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
| 0.1 | 0.5 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 0.1 | 0.6 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731) |
| 0.1 | 1.7 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 0.1 | 1.0 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.1 | 1.1 | GO:0035745 | T-helper 2 cell cytokine production(GO:0035745) |
| 0.1 | 0.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.1 | 0.3 | GO:1905225 | cellular response to glycoprotein(GO:1904588) response to thyrotropin-releasing hormone(GO:1905225) cellular response to thyrotropin-releasing hormone(GO:1905229) |
| 0.1 | 0.2 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.1 | 3.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 2.2 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.1 | 1.4 | GO:0006144 | purine nucleobase metabolic process(GO:0006144) |
| 0.1 | 0.4 | GO:0048840 | otolith development(GO:0048840) |
| 0.1 | 0.6 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.1 | 0.2 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 0.1 | 3.7 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.1 | 0.7 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.1 | 0.6 | GO:0048003 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.1 | 2.8 | GO:0002820 | negative regulation of adaptive immune response(GO:0002820) |
| 0.1 | 1.0 | GO:0071498 | cellular response to fluid shear stress(GO:0071498) |
| 0.1 | 2.5 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.1 | 0.5 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.1 | 1.1 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.1 | 1.0 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.1 | 0.3 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 0.2 | GO:0006683 | galactosylceramide catabolic process(GO:0006683) |
| 0.1 | 0.6 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.1 | 1.1 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.1 | 0.9 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
| 0.0 | 0.7 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 0.0 | 1.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 1.2 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.7 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 0.5 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.0 | 4.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.6 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.5 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.0 | 0.6 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 1.7 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.8 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.4 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 1.5 | GO:0051569 | regulation of histone H3-K4 methylation(GO:0051569) |
| 0.0 | 0.7 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.0 | 1.0 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.0 | 0.7 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 1.2 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.3 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.0 | 0.1 | GO:0010836 | base-excision repair, DNA ligation(GO:0006288) negative regulation of protein ADP-ribosylation(GO:0010836) |
| 0.0 | 0.3 | GO:1905146 | lysosomal lumen acidification(GO:0007042) lysosomal protein catabolic process(GO:1905146) |
| 0.0 | 1.3 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
| 0.0 | 0.7 | GO:0071888 | macrophage apoptotic process(GO:0071888) |
| 0.0 | 1.0 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.0 | 0.6 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.0 | 0.4 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.0 | 0.7 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) |
| 0.0 | 0.8 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.0 | 0.3 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 3.4 | GO:0051351 | positive regulation of ligase activity(GO:0051351) |
| 0.0 | 0.8 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.5 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 0.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.4 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) |
| 0.0 | 0.6 | GO:0060080 | inhibitory postsynaptic potential(GO:0060080) |
| 0.0 | 3.7 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.0 | 0.1 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.0 | 0.1 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.0 | 0.1 | GO:0051454 | pH elevation(GO:0045852) intracellular pH elevation(GO:0051454) |
| 0.0 | 1.6 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.4 | GO:0008334 | histone mRNA metabolic process(GO:0008334) |
| 0.0 | 0.0 | GO:0072719 | cellular response to cisplatin(GO:0072719) |
| 0.0 | 1.6 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.0 | 0.6 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.8 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.0 | 0.4 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.2 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.0 | 0.0 | GO:1901355 | response to rapamycin(GO:1901355) |
| 0.0 | 0.1 | GO:0016264 | purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868) gap junction assembly(GO:0016264) |
| 0.0 | 0.4 | GO:0042104 | positive regulation of activated T cell proliferation(GO:0042104) |
| 0.0 | 3.2 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.0 | 2.0 | GO:0030307 | positive regulation of cell growth(GO:0030307) |
| 0.0 | 1.3 | GO:0018022 | peptidyl-lysine methylation(GO:0018022) |
| 0.0 | 0.6 | GO:0035116 | embryonic hindlimb morphogenesis(GO:0035116) |
| 0.0 | 1.9 | GO:0016573 | histone acetylation(GO:0016573) |
| 0.0 | 1.1 | GO:0042472 | inner ear morphogenesis(GO:0042472) |
| 0.0 | 0.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 5.6 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 1.0 | 9.7 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.7 | 2.2 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.6 | 7.9 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.4 | 2.1 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.4 | 2.0 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.4 | 1.4 | GO:0071920 | cleavage body(GO:0071920) |
| 0.3 | 1.9 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.3 | 1.2 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.3 | 2.5 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.3 | 1.8 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.3 | 0.8 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.2 | 4.7 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 1.2 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.2 | 1.5 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.2 | 2.5 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 1.5 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.1 | 1.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 1.9 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.1 | 0.1 | GO:0070522 | ERCC4-ERCC1 complex(GO:0070522) |
| 0.1 | 1.6 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 2.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 1.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 0.5 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.1 | 2.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 1.6 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 0.5 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 0.4 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.1 | 1.4 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 1.8 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 0.5 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.1 | 1.2 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 2.8 | GO:0000791 | euchromatin(GO:0000791) |
| 0.1 | 6.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 5.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 10.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 0.8 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.1 | 3.2 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.1 | 0.2 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 0.1 | 1.0 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.1 | 0.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 0.4 | GO:0034715 | U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715) |
| 0.1 | 10.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.0 | GO:0044453 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.0 | 0.5 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 2.1 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.6 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 1.1 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.8 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 0.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.6 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 3.1 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.1 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.0 | 12.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 2.8 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 2.2 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.4 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 4.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 1.0 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.3 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.0 | 2.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.8 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 1.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.3 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 2.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.3 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.1 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.1 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 0.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.3 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.0 | 0.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.3 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.3 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.6 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 1.0 | 3.0 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 1.0 | 2.9 | GO:0004418 | hydroxymethylbilane synthase activity(GO:0004418) |
| 0.8 | 2.5 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.8 | 2.5 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.8 | 2.3 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.6 | 4.4 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.6 | 1.8 | GO:0004750 | ribulose-phosphate 3-epimerase activity(GO:0004750) |
| 0.5 | 1.6 | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity(GO:0003860) |
| 0.5 | 8.2 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.4 | 2.1 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.4 | 5.6 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.4 | 4.4 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.3 | 1.4 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.3 | 1.3 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.3 | 0.9 | GO:0047315 | kynurenine-glyoxylate transaminase activity(GO:0047315) |
| 0.3 | 1.5 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.3 | 0.8 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 0.3 | 3.9 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.2 | 4.9 | GO:0005522 | profilin binding(GO:0005522) |
| 0.2 | 1.1 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.2 | 1.8 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.2 | 0.8 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.2 | 3.7 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.2 | 2.9 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 2.0 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.2 | 3.4 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.2 | 1.6 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.2 | 0.8 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.2 | 1.2 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.2 | 2.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 1.3 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.1 | 1.3 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.1 | 0.7 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.1 | 0.4 | GO:0005260 | channel-conductance-controlling ATPase activity(GO:0005260) |
| 0.1 | 1.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.1 | 0.8 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) leukotriene-B4 20-monooxygenase activity(GO:0050051) |
| 0.1 | 1.1 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 0.8 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 1.4 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.1 | 1.1 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 1.7 | GO:0031432 | titin binding(GO:0031432) |
| 0.1 | 1.4 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 2.3 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 2.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 1.3 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 1.7 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.1 | 1.0 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 0.4 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
| 0.1 | 9.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 0.5 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.1 | 1.0 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.1 | 0.5 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 3.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 0.6 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 1.2 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 2.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.8 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 1.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 0.7 | GO:0003909 | DNA ligase activity(GO:0003909) |
| 0.1 | 0.9 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.1 | 2.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 1.9 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 1.0 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.1 | 1.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 1.0 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 0.6 | GO:0030883 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.1 | 0.7 | GO:0005549 | odorant binding(GO:0005549) |
| 0.1 | 3.1 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 1.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 0.3 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.1 | 3.7 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 0.5 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.1 | 1.5 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 0.2 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.1 | 0.7 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.1 | 0.2 | GO:0004336 | galactosylceramidase activity(GO:0004336) |
| 0.1 | 1.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 1.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 2.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.2 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 6.0 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 4.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 1.5 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.6 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.0 | 0.6 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.5 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 0.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.5 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 0.2 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.0 | 0.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.3 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
| 0.0 | 0.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.7 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 1.0 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 0.6 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 0.3 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.0 | 1.6 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 2.1 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.6 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.2 | GO:0031705 | bombesin receptor binding(GO:0031705) |
| 0.0 | 0.1 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.0 | 3.7 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 1.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 1.5 | GO:0016248 | channel inhibitor activity(GO:0016248) |
| 0.0 | 3.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 2.5 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.4 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.0 | 1.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 1.0 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.4 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 4.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.7 | GO:0015301 | anion:anion antiporter activity(GO:0015301) |
| 0.0 | 2.1 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.4 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 0.5 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.0 | 0.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.5 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.6 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 1.3 | GO:0016278 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.0 | 1.0 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.0 | 0.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 1.4 | GO:0043566 | structure-specific DNA binding(GO:0043566) |
| 0.0 | 1.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.7 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 1.1 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.0 | 0.4 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 1.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.3 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.1 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.0 | 0.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.1 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.0 | 0.1 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.0 | 1.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 0.7 | GO:0050661 | NADP binding(GO:0050661) |
| 0.0 | 0.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 0.1 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 4.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 1.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 4.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 4.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 2.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 5.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 1.4 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 1.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 2.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 4.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 9.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.4 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.1 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 3.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 7.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.9 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.7 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 0.7 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 2.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.1 | 1.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 4.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 1.4 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 2.4 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 3.7 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 2.9 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 6.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 1.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 1.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 4.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.4 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 0.5 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 0.8 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 1.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 0.6 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 1.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 1.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.8 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.5 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 2.9 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.0 | 0.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.5 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 1.1 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.5 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 1.9 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 1.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.8 | REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.0 | 2.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.8 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.4 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 1.1 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.7 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.6 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.7 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.6 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.3 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 3.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.2 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.3 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 2.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.4 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.6 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.8 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 0.2 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 1.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.3 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |