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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX2-5

Z-value: 4.40

Motif logo

Transcription factors associated with NKX2-5

Gene Symbol Gene ID Gene Info
ENSG00000183072.10 NKX2-5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-5hg38_v1_chr5_-_173235194_1732352130.055.0e-01Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chrX_-_13817027 16.23 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr8_-_119638780 13.92 ENST00000522826.5
ENST00000520066.5
ENST00000259486.10
ENST00000075322.11
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr19_+_16888991 13.90 ENST00000248076.4
F2R like thrombin or trypsin receptor 3
chr15_+_42404700 12.18 ENST00000674093.1
calpain 3
chr3_+_125969152 11.80 ENST00000251776.8
ENST00000504401.1
rhophilin associated tail protein 1B
chr15_-_80989792 11.14 ENST00000261758.6
ENST00000561312.5
mesoderm development LRP chaperone
chr3_+_125969172 11.04 ENST00000514116.6
ENST00000513830.5
rhophilin associated tail protein 1B
chr12_+_123233420 10.92 ENST00000253233.6
ENST00000366329.7
ENST00000546132.2
ENST00000536130.2
chromosome 12 open reading frame 65
chr17_-_58544315 10.87 ENST00000671766.1
ENST00000672673.2
ENST00000321691.3
septin 4
chr15_+_42404820 10.75 ENST00000673839.1
ENST00000673978.1
calpain 3
chr21_+_42893280 10.40 ENST00000354250.7
NADH:ubiquinone oxidoreductase subunit V3
chr15_+_42404793 10.23 ENST00000561817.5
ENST00000674018.1
ENST00000397204.9
ENST00000673886.1
ENST00000674139.1
ENST00000673851.1
calpain 3
chr3_-_123992046 10.16 ENST00000467907.5
ENST00000459660.5
ENST00000495093.1
ENST00000460743.5
ENST00000405845.7
ENST00000484329.1
ENST00000479867.1
ENST00000496145.5
rhophilin associated tail protein 1
chr7_+_100177897 9.94 ENST00000317296.9
ENST00000615138.5
ENST00000620100.5
ENST00000422690.5
ENST00000439782.1
stromal antigen 3
chr7_+_100177743 9.78 ENST00000394018.6
ENST00000416412.5
stromal antigen 3
chr15_+_42404719 9.68 ENST00000569136.6
ENST00000673936.1
ENST00000673890.1
ENST00000674149.1
ENST00000673771.1
ENST00000337571.9
ENST00000673743.1
ENST00000674146.1
ENST00000674119.1
ENST00000356316.7
ENST00000673692.1
ENST00000674052.1
calpain 3
chr3_+_125969214 9.48 ENST00000508088.1
rhophilin associated tail protein 1B
chr14_-_21048431 9.39 ENST00000555026.5
NDRG family member 2
chr5_-_74767105 8.96 ENST00000509430.5
ENST00000296805.8
ENST00000345239.6
ENST00000427854.6
ENST00000506778.1
GTP dependent ribosome recycling factor mitochondrial 2
chr22_-_38181772 8.85 ENST00000430886.5
ENST00000667521.1
ENST00000663895.1
ENST00000402064.5
ENST00000332509.8
ENST00000664587.1
phospholipase A2 group VI
chr21_+_42893265 8.83 ENST00000340344.4
NADH:ubiquinone oxidoreductase subunit V3
chr15_+_90265634 8.65 ENST00000379095.5
neugrin, neurite outgrowth associated
chr5_-_150412743 8.40 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74 molecule
chr22_-_38181707 8.30 ENST00000668949.1
ENST00000335539.7
phospholipase A2 group VI
chr5_+_34929524 8.20 ENST00000648817.1
DnaJ heat shock protein family (Hsp40) member C21
chr17_-_69150062 8.19 ENST00000522787.5
ENST00000521538.5
ATP binding cassette subfamily A member 10
chr17_-_8376658 8.11 ENST00000643221.1
ENST00000647210.1
ENST00000649935.1
ENST00000396267.3
KRAB-A domain containing 2
chr3_+_121567924 7.79 ENST00000334384.5
arginine-fifty homeobox
chr3_-_187670385 7.74 ENST00000287641.4
somatostatin
chr8_+_132866948 7.62 ENST00000220616.9
thyroglobulin
chr12_+_93378625 7.31 ENST00000546925.1
nudix hydrolase 4
chr19_+_5681000 7.11 ENST00000581893.5
ENST00000411793.6
ENST00000301382.8
ENST00000581773.5
ENST00000339423.7
ENST00000423665.6
ENST00000583928.5
ENST00000342970.6
ENST00000422535.6
ENST00000581521.5
hydroxysteroid 11-beta dehydrogenase 1 like
chr15_-_42548763 6.50 ENST00000563454.5
ENST00000397130.8
ENST00000570160.1
ENST00000323443.6
leucine rich repeat containing 57
chr17_+_28728781 6.37 ENST00000268766.11
NIMA related kinase 8
chr5_-_160685379 6.30 ENST00000642502.1
ATPase phospholipid transporting 10B (putative)
chr2_-_151261839 6.29 ENST00000331426.6
RNA binding motif protein 43
chr5_+_141350081 6.01 ENST00000523390.2
ENST00000611598.1
protocadherin gamma subfamily B, 1
chr17_-_15341577 5.97 ENST00000543896.1
ENST00000395930.6
ENST00000539245.5
ENST00000539316.1
tektin 3
chr17_-_31314066 5.75 ENST00000577894.1
ecotropic viral integration site 2B
chr20_-_43189733 5.52 ENST00000373187.5
ENST00000356100.6
ENST00000373184.5
ENST00000373190.5
protein tyrosine phosphatase receptor type T
chr4_+_113049479 5.49 ENST00000671727.1
ENST00000671762.1
ENST00000672366.1
ENST00000672502.1
ENST00000672045.1
ENST00000672251.1
ENST00000672854.1
ankyrin 2
chr2_-_201071579 5.37 ENST00000453765.5
ENST00000452799.5
ENST00000446678.5
ENST00000418596.7
ENST00000681958.1
family with sequence similarity 126 member B
chr10_-_100081854 5.24 ENST00000370418.8
carboxypeptidase N subunit 1
chr3_-_194351290 5.21 ENST00000429275.1
ENST00000323830.4
carboxypeptidase N subunit 2
chr3_-_155745016 5.18 ENST00000460012.7
phospholipase C eta 1
chr4_+_113049616 5.17 ENST00000504454.5
ENST00000357077.9
ENST00000394537.7
ENST00000672779.1
ENST00000264366.10
ankyrin 2
chr17_+_55264952 5.14 ENST00000226067.10
HLF transcription factor, PAR bZIP family member
chr12_-_112382363 5.13 ENST00000682272.1
ENST00000377560.9
HECT domain E3 ubiquitin protein ligase 4
chrX_-_30308333 5.12 ENST00000378963.1
nuclear receptor subfamily 0 group B member 1
chr10_+_74826550 5.07 ENST00000649657.1
ENST00000372714.6
ENST00000649442.1
ENST00000648539.1
ENST00000647666.1
ENST00000648048.1
ENST00000287239.10
ENST00000649375.1
lysine acetyltransferase 6B
chr1_-_203182805 5.01 ENST00000404436.2
chitinase 3 like 1
chr17_-_48590231 4.96 ENST00000476342.1
ENST00000460160.5
ENST00000498678.6
ENST00000472863.5
homeobox B3
chrX_-_50200988 4.89 ENST00000358526.7
A-kinase anchoring protein 4
chr10_+_18340821 4.80 ENST00000612743.1
ENST00000612134.4
calcium voltage-gated channel auxiliary subunit beta 2
chr15_+_42548810 4.77 ENST00000568876.5
ENST00000568846.6
ENST00000562398.5
ENST00000260372.8
HAUS augmin like complex subunit 2
chr17_+_60677822 4.76 ENST00000407086.8
ENST00000589222.5
ENST00000626960.2
ENST00000390652.9
BCAS3 microtubule associated cell migration factor
chr11_+_108223112 4.70 ENST00000452508.6
ENST00000683914.1
ENST00000683150.1
ENST00000639953.1
ENST00000640388.1
ENST00000639240.1
ATM serine/threonine kinase
chr22_+_38057200 4.70 ENST00000404072.7
ENST00000424694.5
protein interacting with PRKCA 1
chr22_-_50085331 4.45 ENST00000395876.6
modulator of VRAC current 1
chr19_-_5680488 4.45 ENST00000587589.1
ENST00000309324.9
mitochondrial contact site and cristae organizing system subunit 13
chr1_+_65309517 4.41 ENST00000371069.5
DnaJ heat shock protein family (Hsp40) member C6
chr11_+_108223027 4.40 ENST00000675843.1
ENST00000683468.1
ENST00000532931.5
ENST00000530958.5
ATM serine/threonine kinase
chr17_-_59964714 4.35 ENST00000589113.1
ENST00000305783.13
ring finger protein, transmembrane 1
chr1_+_100351698 4.22 ENST00000644676.1
cell division cycle 14A
chr17_-_7929793 4.08 ENST00000303790.3
potassium voltage-gated channel subfamily A regulatory beta subunit 3
chr22_-_50085414 4.07 ENST00000311597.10
modulator of VRAC current 1
chr5_+_79111802 4.03 ENST00000524080.1
ENST00000274353.10
betaine--homocysteine S-methyltransferase
chrX_-_14029877 3.92 ENST00000680255.1
ENST00000380523.8
ENST00000398355.7
gem nuclear organelle associated protein 8
chr6_+_29587455 3.86 ENST00000383640.4
olfactory receptor family 2 subfamily H member 2
chr10_-_48605032 3.81 ENST00000249601.9
Rho GTPase activating protein 22
chr10_+_18340699 3.78 ENST00000377329.10
calcium voltage-gated channel auxiliary subunit beta 2
chr1_+_50105666 3.72 ENST00000651347.1
ELAV like RNA binding protein 4
chr6_+_33410961 3.62 ENST00000374512.7
ENST00000374516.8
PHD finger protein 1
chr20_+_21126074 3.49 ENST00000619189.5
kizuna centrosomal protein
chr1_+_14924100 3.42 ENST00000361144.9
kazrin, periplakin interacting protein
chr10_-_79560386 3.42 ENST00000372327.9
ENST00000417041.1
ENST00000640627.1
ENST00000372325.7
surfactant protein A2
chr1_-_11847772 3.35 ENST00000376480.7
ENST00000610706.1
natriuretic peptide A
chr16_-_30123203 3.34 ENST00000395202.5
ENST00000395199.7
ENST00000263025.9
ENST00000322266.9
mitogen-activated protein kinase 3
chr20_+_54475584 3.29 ENST00000262593.10
docking protein 5
chr6_-_111793871 3.27 ENST00000368667.6
FYN proto-oncogene, Src family tyrosine kinase
chr3_-_139539679 3.20 ENST00000483943.6
ENST00000672186.1
ENST00000232219.6
ENST00000617459.4
ENST00000492918.1
retinol binding protein 1
chr3_+_186996444 3.18 ENST00000676633.1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr10_+_74826406 3.16 ENST00000648892.1
ENST00000647890.1
ENST00000372724.6
lysine acetyltransferase 6B
chr17_-_10549694 3.15 ENST00000622564.4
myosin heavy chain 2
chr3_+_46242453 3.14 ENST00000452454.1
ENST00000395940.3
ENST00000457243.1
C-C motif chemokine receptor 3
chr17_-_27893339 3.13 ENST00000460380.6
ENST00000379102.8
ENST00000508862.5
ENST00000582441.1
LYR motif containing 9
novel protein
chr11_+_60971777 3.02 ENST00000542157.5
ENST00000433107.6
ENST00000352009.9
ENST00000452451.6
CD6 molecule
chr14_+_80955043 3.00 ENST00000541158.6
thyroid stimulating hormone receptor
chr16_-_30122944 2.99 ENST00000484663.5
ENST00000478356.5
mitogen-activated protein kinase 3
chr8_-_71547626 2.98 ENST00000647540.1
ENST00000644229.1
EYA transcriptional coactivator and phosphatase 1
chr2_-_166149120 2.98 ENST00000641575.1
ENST00000641603.1
sodium voltage-gated channel alpha subunit 1
chr6_+_32153441 2.96 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
palmitoyl-protein thioesterase 2
chr12_+_109573757 2.94 ENST00000228510.8
ENST00000539696.5
ENST00000392727.7
mevalonate kinase
chr14_+_20999255 2.91 ENST00000554422.5
ENST00000298681.5
solute carrier family 39 member 2
chrX_+_11759678 2.90 ENST00000649797.1
ENST00000648614.1
MSL complex subunit 3
chr7_-_14902743 2.90 ENST00000402815.6
diacylglycerol kinase beta
chr3_+_46242371 2.89 ENST00000545097.1
C-C motif chemokine receptor 3
chr10_+_114179249 2.81 ENST00000369282.5
ENST00000251864.6
tudor domain containing 1
chr7_+_129368123 2.80 ENST00000460109.5
ENST00000474594.5
adenosylhomocysteinase like 2
chr17_+_50547089 2.77 ENST00000619622.4
ENST00000356488.8
ENST00000006658.11
spermatogenesis associated 20
chr1_+_32205657 2.77 ENST00000291358.11
ENST00000537469.2
IQ motif containing C
chr12_+_110614027 2.76 ENST00000550703.6
ENST00000551590.5
tectonic family member 1
chr17_+_4932248 2.69 ENST00000329125.6
glycoprotein Ib platelet subunit alpha
chr10_-_118046574 2.67 ENST00000369199.5
RAB11 family interacting protein 2
chr11_+_118883884 2.62 ENST00000292174.5
C-X-C motif chemokine receptor 5
chr16_+_715092 2.60 ENST00000568223.7
meteorin, glial cell differentiation regulator
chr2_-_175168159 2.55 ENST00000392544.5
ENST00000409499.5
ENST00000409833.5
ENST00000264110.7
ENST00000409635.5
ENST00000345739.9
ENST00000426833.7
activating transcription factor 2
chr14_+_94174284 2.55 ENST00000304338.8
protein phosphatase 4 regulatory subunit 4
chr2_-_166149204 2.50 ENST00000635750.1
sodium voltage-gated channel alpha subunit 1
chr3_-_15333152 2.50 ENST00000426925.5
SH3 domain binding protein 5
chr7_-_87713287 2.46 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ATP binding cassette subfamily B member 1
chr11_+_124954108 2.43 ENST00000529051.5
coiled-coil domain containing 15
chr14_-_106875069 2.31 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr12_-_262828 2.30 ENST00000343164.9
ENST00000436453.1
ENST00000445055.6
ENST00000546319.5
solute carrier family 6 member 13
chr12_-_48865863 2.26 ENST00000309739.6
Rho family GTPase 1
chr13_-_40666600 2.21 ENST00000379561.6
forkhead box O1
chr1_+_113905290 2.19 ENST00000650450.2
DNA cross-link repair 1B
chr1_-_160070150 2.13 ENST00000644903.1
potassium inwardly rectifying channel subfamily J member 10
chr14_+_80955577 2.11 ENST00000642209.1
ENST00000298171.7
thyroid stimulating hormone receptor
chr2_+_218782138 2.11 ENST00000258415.9
cytochrome P450 family 27 subfamily A member 1
chr9_-_127847117 2.10 ENST00000480266.5
endoglin
chr2_+_48314637 2.06 ENST00000413569.5
ENST00000340553.8
forkhead box N2
chr20_-_57710539 2.02 ENST00000395816.7
ENST00000347215.8
prostate transmembrane protein, androgen induced 1
chr9_-_135501734 2.02 ENST00000371791.5
chromosome 9 open reading frame 116
chr16_+_77199408 2.02 ENST00000378644.5
synaptonemal complex central element protein 1 like
chr17_-_7590072 1.96 ENST00000538513.6
ENST00000570788.1
ENST00000250055.3
SRY-box transcription factor 15
chr20_-_44210697 1.95 ENST00000255174.3
oxidative stress responsive serine rich 1
chr1_-_160070102 1.87 ENST00000638728.1
ENST00000637644.1
potassium inwardly rectifying channel subfamily J member 10
chr18_+_63907948 1.86 ENST00000238508.8
serpin family B member 10
chr8_-_104467042 1.82 ENST00000521573.2
ENST00000351513.7
dihydropyrimidinase
chr6_+_32154010 1.80 ENST00000375137.6
palmitoyl-protein thioesterase 2
chr14_+_80955366 1.78 ENST00000342443.10
thyroid stimulating hormone receptor
chr1_-_202889099 1.75 ENST00000367262.4
RAB interacting factor
chr20_+_54475647 1.74 ENST00000395939.5
docking protein 5
chr17_-_10549612 1.69 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
myosin heavy chain 2
chr8_-_142786530 1.60 ENST00000301263.5
lymphocyte antigen 6 family member D
chr1_-_155188351 1.58 ENST00000462317.5
mucin 1, cell surface associated
chr1_+_19882374 1.57 ENST00000375120.4
OTU deubiquitinase 3
chr3_+_108602776 1.55 ENST00000497905.5
ENST00000463306.1
DAZ interacting zinc finger protein 3
chr16_+_8720706 1.49 ENST00000425191.6
ENST00000569156.5
4-aminobutyrate aminotransferase
chr5_+_141430565 1.47 ENST00000613314.1
protocadherin gamma subfamily A, 12
chr11_+_61203512 1.44 ENST00000325558.11
pepsinogen A3
chr7_+_130380339 1.43 ENST00000481342.5
ENST00000604896.5
ENST00000011292.8
carboxypeptidase A1
chr7_-_128775793 1.41 ENST00000249389.3
opsin 1, short wave sensitive
chr1_+_159826860 1.37 ENST00000289707.10
SLAM family member 8
chr17_-_3597098 1.35 ENST00000571088.5
transient receptor potential cation channel subfamily V member 1
chr3_-_184378201 1.31 ENST00000647395.1
thrombopoietin
chr8_-_94208548 1.29 ENST00000027335.8
ENST00000441892.6
ENST00000521491.1
cadherin 17
chr1_+_154327737 1.27 ENST00000672630.1
ATPase phospholipid transporting 8B2
chrX_-_155071064 1.24 ENST00000369484.8
ENST00000369476.8
C-X9-C motif containing 4
mature T cell proliferation 1
chr13_-_52848632 1.24 ENST00000377942.7
ENST00000338862.5
protocadherin 8
chr15_-_74433942 1.22 ENST00000543145.6
ENST00000261918.9
semaphorin 7A (John Milton Hagen blood group)
chr1_+_186828941 1.20 ENST00000367466.4
phospholipase A2 group IVA
chr1_-_150010675 1.20 ENST00000417191.2
ENST00000581312.6
OTU deubiquitinase 7B
chr17_-_10549652 1.17 ENST00000245503.10
myosin heavy chain 2
chr14_+_80955650 1.16 ENST00000554263.5
ENST00000554435.1
thyroid stimulating hormone receptor
chr14_-_106507476 1.14 ENST00000390621.3
immunoglobulin heavy variable 1-45
chr12_+_110614097 1.07 ENST00000471804.7
ENST00000377654.5
ENST00000614115.5
ENST00000397655.7
ENST00000549123.6
ENST00000679401.1
ENST00000397659.9
ENST00000680445.1
tectonic family member 1
chr13_+_108596152 1.04 ENST00000356711.7
ENST00000251041.10
myosin XVI
chrX_+_87517784 1.02 ENST00000373119.9
ENST00000373114.4
kelch like family member 4
chr11_+_26332117 1.00 ENST00000531646.1
ENST00000256737.8
anoctamin 3
chr15_-_72271244 0.99 ENST00000287196.13
poly(ADP-ribose) polymerase family member 6
chr9_-_114930508 0.97 ENST00000223795.3
ENST00000618336.4
TNF superfamily member 8
chr6_-_93419545 0.96 ENST00000369297.1
ENST00000369303.9
ENST00000680224.1
ENST00000681532.1
ENST00000679565.1
EPH receptor A7
chr9_-_14313642 0.90 ENST00000637742.1
nuclear factor I B
chr11_+_99021066 0.78 ENST00000527185.5
ENST00000528682.5
contactin 5
chr1_+_202462730 0.73 ENST00000290419.9
ENST00000491336.5
protein phosphatase 1 regulatory subunit 12B
chr17_-_81656532 0.70 ENST00000331056.10
phosphodiesterase 6G
chr7_+_130266847 0.70 ENST00000222481.9
carboxypeptidase A2
chr1_-_21783189 0.66 ENST00000400301.5
ENST00000532737.1
ubiquitin specific peptidase 48
chr2_+_151357583 0.59 ENST00000243347.5
TNF alpha induced protein 6
chr3_-_56683218 0.56 ENST00000355628.9
ENST00000683822.1
transcription activation suppressor
chr3_+_42160160 0.54 ENST00000341421.7
ENST00000396175.5
trafficking kinesin protein 1
chrX_+_14529516 0.54 ENST00000218075.9
glycine receptor alpha 2
chr18_-_13915531 0.45 ENST00000327606.4
melanocortin 2 receptor
chr4_+_152779934 0.44 ENST00000451320.6
ENST00000429148.6
ENST00000353617.7
ENST00000405727.6
ENST00000356064.3
ADP ribosylation factor interacting protein 1
chr6_-_41747390 0.41 ENST00000356667.8
ENST00000373025.7
ENST00000425343.6
progastricsin
chr7_-_81770122 0.38 ENST00000423064.7
hepatocyte growth factor
chr19_+_35106510 0.35 ENST00000648240.1
novel protein
chr7_-_44189428 0.34 ENST00000673284.1
ENST00000403799.8
ENST00000671824.1
glucokinase
chr18_+_44697118 0.32 ENST00000677077.1
SET binding protein 1
chr19_-_10836273 0.28 ENST00000591695.5
transmembrane p24 trafficking protein 1
chr2_-_174634566 0.27 ENST00000392547.6
WAS/WASL interacting protein family member 1
chr8_+_75539893 0.25 ENST00000674002.1
hepatocyte nuclear factor 4 gamma
chrX_-_84188148 0.23 ENST00000262752.5
ribosomal protein S6 kinase A6
chr19_-_10836195 0.21 ENST00000589638.1
ENST00000214869.7
transmembrane p24 trafficking protein 1
chr17_-_31314040 0.18 ENST00000330927.5
ecotropic viral integration site 2B
chr16_-_57775103 0.18 ENST00000540079.6
ENST00000569222.5
kinesin family member C3
chrX_+_11759604 0.16 ENST00000649602.1
ENST00000650215.1
ENST00000649685.1
ENST00000649649.1
ENST00000380693.8
ENST00000380692.7
ENST00000650628.1
ENST00000649851.1
ENST00000421368.3
MSL complex subunit 3
chr11_+_65111845 0.12 ENST00000526809.5
ENST00000524986.5
ENST00000534371.5
ENST00000279263.14
ENST00000525385.5
ENST00000345348.9
ENST00000531321.5
ENST00000529414.5
ENST00000526085.5
ENST00000530750.5
transmembrane 7 superfamily member 2
chr4_-_167234426 0.08 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr3_+_45943455 0.04 ENST00000304552.5
C-X-C motif chemokine receptor 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 42.8 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
4.3 17.1 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
3.0 9.1 GO:1904882 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
2.8 8.4 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
2.0 8.1 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
2.0 2.0 GO:0014717 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
1.7 13.9 GO:0060155 platelet dense granule organization(GO:0060155)
1.5 7.7 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
1.5 32.3 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
1.5 6.0 GO:0080154 regulation of fertilization(GO:0080154)
1.4 16.2 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.3 21.7 GO:0007130 synaptonemal complex assembly(GO:0007130)
1.3 3.8 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
1.2 5.0 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
1.2 8.6 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
1.2 10.9 GO:0072344 rescue of stalled ribosome(GO:0072344)
1.1 10.7 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.1 6.3 GO:0000189 MAPK import into nucleus(GO:0000189)
1.0 5.2 GO:0030070 insulin processing(GO:0030070)
1.0 9.0 GO:0032790 ribosome disassembly(GO:0032790)
1.0 2.9 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
1.0 7.6 GO:0015705 iodide transport(GO:0015705)
0.9 13.9 GO:0034638 phosphatidylcholine catabolic process(GO:0034638) positive regulation of lamellipodium morphogenesis(GO:2000394)
0.9 3.6 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.8 3.4 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.8 4.1 GO:0071543 diadenosine polyphosphate metabolic process(GO:0015959) diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.8 4.0 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.8 4.7 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.7 11.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.7 2.1 GO:0001300 chronological cell aging(GO:0001300)
0.6 1.8 GO:0019482 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) beta-alanine metabolic process(GO:0019482) thymine metabolic process(GO:0019859)
0.6 9.4 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.6 8.1 GO:0015074 DNA integration(GO:0015074)
0.6 4.0 GO:0050666 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.6 2.2 GO:1902617 response to fluoride(GO:1902617)
0.5 2.2 GO:0031627 telomeric loop formation(GO:0031627)
0.5 8.7 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.5 5.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.5 5.0 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.5 6.4 GO:0035330 regulation of hippo signaling(GO:0035330)
0.4 4.8 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.4 1.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.4 2.8 GO:0034587 piRNA metabolic process(GO:0034587)
0.4 6.0 GO:0001778 plasma membrane repair(GO:0001778)
0.4 2.8 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 1.6 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.4 1.5 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.4 4.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.4 2.5 GO:0009414 response to water deprivation(GO:0009414)
0.3 1.3 GO:0050968 detection of temperature stimulus involved in thermoception(GO:0050960) detection of chemical stimulus involved in sensory perception of pain(GO:0050968) response to capsazepine(GO:1901594)
0.3 1.0 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.3 3.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 5.0 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.3 1.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.3 1.2 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3 7.6 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.3 1.3 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.2 3.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.2 4.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 3.0 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.2 3.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 1.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 2.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 2.3 GO:0016322 neuron remodeling(GO:0016322)
0.1 2.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.5 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.1 1.6 GO:0035634 response to stilbenoid(GO:0035634)
0.1 8.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 2.6 GO:0048535 lymph node development(GO:0048535)
0.1 2.9 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 4.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 1.6 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.1 2.7 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 8.2 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 2.5 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 7.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 1.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.0 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.1 3.8 GO:0007618 mating(GO:0007618)
0.1 0.9 GO:2000795 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 14.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.5 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 2.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 1.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.4 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 6.0 GO:0006968 positive regulation of endothelial cell proliferation(GO:0001938) cellular defense response(GO:0006968)
0.1 5.2 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 0.5 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 0.3 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 3.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 2.1 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.7 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 3.4 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.4 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 2.7 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773)
0.0 3.4 GO:0070268 cornification(GO:0070268)
0.0 0.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.7 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 2.6 GO:0030449 regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257)
0.0 0.9 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 5.1 GO:0006006 glucose metabolic process(GO:0006006)
0.0 2.5 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.6 GO:0030728 ovulation(GO:0030728)
0.0 1.6 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.8 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 1.2 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 3.1 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 1.0 GO:0021549 cerebellum development(GO:0021549)
0.0 0.7 GO:0006501 C-terminal protein lipidation(GO:0006501)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 19.7 GO:0030893 meiotic cohesin complex(GO:0030893)
1.2 6.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.8 8.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.7 8.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.7 2.8 GO:0071546 pi-body(GO:0071546)
0.7 2.1 GO:0072563 endothelial microparticle(GO:0072563)
0.6 4.2 GO:0060091 kinocilium(GO:0060091)
0.6 63.1 GO:0030315 T-tubule(GO:0030315)
0.5 4.8 GO:0070652 HAUS complex(GO:0070652)
0.5 3.9 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.5 4.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 5.1 GO:0042788 polysomal ribosome(GO:0042788)
0.4 1.5 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.3 1.6 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.3 38.3 GO:0031514 motile cilium(GO:0031514)
0.2 6.3 GO:0031143 pseudopodium(GO:0031143)
0.2 1.4 GO:0097486 multivesicular body lumen(GO:0097486)
0.2 3.8 GO:0036038 MKS complex(GO:0036038)
0.2 4.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 5.8 GO:0035861 site of double-strand break(GO:0035861)
0.2 3.4 GO:0042599 lamellar body(GO:0042599)
0.1 9.1 GO:1990391 DNA repair complex(GO:1990391)
0.1 8.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 3.4 GO:0030057 desmosome(GO:0030057)
0.1 4.7 GO:0016235 aggresome(GO:0016235)
0.1 3.0 GO:0042101 T cell receptor complex(GO:0042101)
0.1 3.4 GO:0042629 mast cell granule(GO:0042629)
0.1 8.5 GO:0005901 caveola(GO:0005901)
0.1 2.1 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 0.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.0 GO:0000795 synaptonemal complex(GO:0000795)
0.1 3.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 5.0 GO:0035580 specific granule lumen(GO:0035580)
0.1 4.8 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.9 GO:0097546 ciliary base(GO:0097546)
0.0 15.4 GO:0045121 membrane raft(GO:0045121)
0.0 13.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 61.4 GO:0005615 extracellular space(GO:0005615)
0.0 6.3 GO:0030426 growth cone(GO:0030426)
0.0 3.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 2.5 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 1.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 4.4 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.7 GO:0031672 A band(GO:0031672)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 2.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 6.6 GO:0009986 cell surface(GO:0009986)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 17.8 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 13.9 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
2.8 16.6 GO:0015057 thrombin receptor activity(GO:0015057)
2.5 42.8 GO:0031432 titin binding(GO:0031432)
2.2 10.9 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
1.9 17.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
1.8 9.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
1.6 4.8 GO:0010698 acetyltransferase activator activity(GO:0010698)
1.2 8.4 GO:0042289 MHC class II protein binding(GO:0042289)
1.1 5.5 GO:0070097 delta-catenin binding(GO:0070097)
1.0 8.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.8 2.5 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.8 4.1 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.7 32.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.7 8.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.7 3.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.6 3.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.6 1.8 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.6 4.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.6 4.0 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 2.8 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.5 5.0 GO:0008061 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.4 4.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 4.8 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.4 3.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.4 12.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 6.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.4 1.5 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.3 9.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 7.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 2.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.3 1.3 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.3 2.7 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.3 2.1 GO:0005534 galactose binding(GO:0005534)
0.3 1.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.2 2.2 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.2 6.3 GO:0004707 MAP kinase activity(GO:0004707)
0.2 1.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 3.2 GO:0016918 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.2 11.4 GO:0030507 spectrin binding(GO:0030507)
0.2 5.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 6.0 GO:0000146 microfilament motor activity(GO:0000146)
0.2 5.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 2.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 2.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 8.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 20.0 GO:0005179 hormone activity(GO:0005179)
0.1 1.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 5.1 GO:0000217 DNA secondary structure binding(GO:0000217)
0.1 1.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.5 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 8.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 3.7 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 8.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 2.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 8.5 GO:0008565 protein transporter activity(GO:0008565)
0.1 3.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 3.8 GO:0035064 methylated histone binding(GO:0035064)
0.1 8.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 2.0 GO:0050699 WW domain binding(GO:0050699)
0.0 5.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.3 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 1.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 4.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 3.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 2.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 5.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.6 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 5.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 2.4 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 1.2 GO:0003774 motor activity(GO:0003774)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 13.9 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.3 6.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 23.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 9.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 5.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 9.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 7.8 PID ARF6 PATHWAY Arf6 signaling events
0.1 3.2 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 2.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.1 PID ALK1 PATHWAY ALK1 signaling events
0.1 6.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.5 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 3.4 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 2.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 ST JNK MAPK PATHWAY JNK MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 18.4 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.8 6.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.8 9.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.6 8.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.4 19.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.4 8.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4 13.9 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.4 8.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.4 6.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 4.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 2.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 4.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 2.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 2.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 4.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 3.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 4.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.4 REACTOME OPSINS Genes involved in Opsins
0.1 1.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 6.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 4.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 8.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 3.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 4.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 12.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 4.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.2 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 4.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.3 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 0.9 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 3.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells