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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX2-6

Z-value: 4.48

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.8 NKX2-6

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_121660892 22.82 ENST00000428394.6
ENST00000314583.8
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr14_-_59870752 19.26 ENST00000611068.1
ENST00000267484.10
RTN1
reticulon 1
chr6_+_32439866 18.29 ENST00000374982.5
ENST00000395388.7
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr17_-_28576882 17.88 ENST00000395319.7
ENST00000581807.5
ENST00000226253.9
ENST00000584086.5
ENST00000395321.6
ALDOC
aldolase, fructose-bisphosphate C
chr12_-_14950606 17.83 ENST00000536592.5
ARHGDIB
Rho GDP dissociation inhibitor beta
chr7_+_142800957 14.78 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr2_+_17541157 12.75 ENST00000406397.1
VSNL1
visinin like 1
chr12_-_49900250 12.46 ENST00000552669.5
FAIM2
Fas apoptotic inhibitory molecule 2
chr7_+_142791635 12.10 ENST00000633705.1
TRBC1
T cell receptor beta constant 1
chr4_+_165378998 10.68 ENST00000402744.9
CPE
carboxypeptidase E
chr22_+_22887780 10.53 ENST00000532223.2
ENST00000526893.6
ENST00000531372.1
IGLL5
immunoglobulin lambda like polypeptide 5
chr17_-_58529303 9.98 ENST00000580844.5
SEPTIN4
septin 4
chr17_-_58529277 9.87 ENST00000579371.5
SEPTIN4
septin 4
chr4_-_155953851 9.73 ENST00000679136.1
ENST00000433477.4
ENST00000679996.1
ENST00000680741.1
ENST00000680553.1
ENST00000679942.1
CTSO
cathepsin O
chr11_-_111379268 9.72 ENST00000393067.8
POU2AF1
POU class 2 homeobox associating factor 1
chr17_-_58529344 9.55 ENST00000317268.7
SEPTIN4
septin 4
chr14_-_105940235 9.36 ENST00000390593.2
IGHV6-1
immunoglobulin heavy variable 6-1
chr8_-_119638780 8.58 ENST00000522826.5
ENST00000520066.5
ENST00000259486.10
ENST00000075322.11
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr19_-_42242526 8.41 ENST00000222330.8
ENST00000676537.1
GSK3A
glycogen synthase kinase 3 alpha
chr15_-_45378519 8.17 ENST00000558163.1
ENST00000396659.8
ENST00000675323.1
ENST00000558336.5
GATM
glycine amidinotransferase
chr2_-_174597728 8.07 ENST00000409891.5
ENST00000410117.5
WIPF1
WAS/WASL interacting protein family member 1
chr7_+_121873152 8.06 ENST00000650826.1
ENST00000650728.1
ENST00000393386.7
ENST00000651390.1
ENST00000651842.1
ENST00000650681.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr22_+_30764252 7.88 ENST00000445781.5
ENST00000401475.5
OSBP2
oxysterol binding protein 2
chr12_+_32106762 7.74 ENST00000551848.1
ENST00000652176.1
BICD1
BICD cargo adaptor 1
chr10_-_5977492 7.73 ENST00000530685.5
ENST00000397255.7
ENST00000379971.5
ENST00000528354.5
ENST00000397250.6
ENST00000429135.2
IL15RA
interleukin 15 receptor subunit alpha
chr22_-_37486357 7.73 ENST00000356998.8
ENST00000416983.7
ENST00000424765.2
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_121873089 7.66 ENST00000651065.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr11_+_1870252 7.57 ENST00000612798.4
LSP1
lymphocyte specific protein 1
chr2_-_174597795 7.27 ENST00000679041.1
WIPF1
WAS/WASL interacting protein family member 1
chr6_+_28267355 7.17 ENST00000614088.1
ENST00000619937.4
ZSCAN26
zinc finger and SCAN domain containing 26
chr1_+_158254414 7.14 ENST00000289429.6
CD1A
CD1a molecule
chr1_+_232950580 7.13 ENST00000366628.10
ENST00000366627.4
NTPCR
nucleoside-triphosphatase, cancer-related
chr3_-_41961989 7.06 ENST00000420927.5
ENST00000301831.9
ENST00000414606.1
ULK4
unc-51 like kinase 4
chr4_+_112818088 7.04 ENST00000673044.1
ENST00000672696.1
ENST00000672315.1
ENST00000672088.1
ENST00000671793.1
ENST00000672402.1
ENST00000671825.1
ENST00000672312.1
ENST00000672830.1
ENST00000672731.1
ENST00000671854.1
ENST00000672350.1
ENST00000672684.1
ENST00000672934.1
ENST00000673546.1
ENST00000673573.1
ENST00000503423.6
ENST00000673255.1
ENST00000671893.1
ENST00000672246.1
ENST00000672930.1
ENST00000673334.1
ENST00000673453.1
ENST00000673555.1
ENST00000672880.1
ENST00000672990.1
ENST00000673430.1
ENST00000673298.1
ENST00000672068.1
ENST00000672362.1
ENST00000672793.1
ENST00000672209.1
ENST00000671756.1
ENST00000671809.1
ENST00000671906.1
ENST00000672090.1
ENST00000672177.1
ENST00000672759.1
ENST00000672965.1
ENST00000673109.1
ENST00000503271.5
ENST00000506722.5
ENST00000673536.1
ENST00000672986.1
ANK2
ankyrin 2
chr4_+_112818032 7.00 ENST00000672356.1
ENST00000672955.1
ANK2
ankyrin 2
chr7_+_150801695 6.99 ENST00000475536.5
ENST00000468689.2
TMEM176A
transmembrane protein 176A
chr2_-_174598206 6.89 ENST00000392546.6
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family member 1
chr6_+_28267044 6.72 ENST00000316606.10
ZSCAN26
zinc finger and SCAN domain containing 26
chr19_+_3178756 6.55 ENST00000246115.5
S1PR4
sphingosine-1-phosphate receptor 4
chr12_-_70788914 6.50 ENST00000342084.8
PTPRR
protein tyrosine phosphatase receptor type R
chr22_-_50085331 6.43 ENST00000395876.6
MLC1
modulator of VRAC current 1
chr13_-_43879696 6.42 ENST00000444614.8
CCDC122
coiled-coil domain containing 122
chr1_-_173824322 6.40 ENST00000356198.6
CENPL
centromere protein L
chr16_+_8712943 6.28 ENST00000561870.5
ENST00000396600.6
ABAT
4-aminobutyrate aminotransferase
chr5_+_140848360 6.24 ENST00000532602.2
PCDHA9
protocadherin alpha 9
chr6_+_28267107 6.19 ENST00000621053.1
ENST00000617168.4
ENST00000421553.7
ENST00000611552.2
ENST00000623276.3
ENSG00000276302.1
ZSCAN26
novel protein
zinc finger and SCAN domain containing 26
chr3_-_15065240 6.05 ENST00000449354.6
ENST00000253686.7
ENST00000444840.6
MRPS25
mitochondrial ribosomal protein S25
chr8_+_84184875 5.83 ENST00000517638.5
ENST00000522647.1
RALYL
RALY RNA binding protein like
chr8_-_70071226 5.58 ENST00000276594.3
PRDM14
PR/SET domain 14
chr1_-_173824107 5.54 ENST00000345664.10
ENST00000367710.7
CENPL
centromere protein L
chr15_+_75347030 5.45 ENST00000566313.5
ENST00000355059.9
ENST00000568059.1
ENST00000568881.1
NEIL1
nei like DNA glycosylase 1
chr10_-_5977535 5.37 ENST00000379977.8
IL15RA
interleukin 15 receptor subunit alpha
chr1_-_173824856 5.35 ENST00000682279.1
CENPL
centromere protein L
chr2_+_69915041 5.29 ENST00000540449.5
MXD1
MAX dimerization protein 1
chr12_-_49897056 5.23 ENST00000552863.5
FAIM2
Fas apoptotic inhibitory molecule 2
chr1_-_200669708 5.15 ENST00000436897.1
ENST00000447706.6
ENST00000331314.11
DDX59
DEAD-box helicase 59
chr14_-_106762576 5.10 ENST00000624687.1
IGHV1-69D
immunoglobulin heavy variable 1-69D
chr1_+_158289916 5.07 ENST00000368170.8
CD1C
CD1c molecule
chr3_+_186996444 4.95 ENST00000676633.1
ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr1_+_109619827 4.89 ENST00000667949.2
ENST00000342115.8
ENST00000528667.7
AMPD2
adenosine monophosphate deaminase 2
chr12_-_262828 4.86 ENST00000343164.9
ENST00000436453.1
ENST00000445055.6
ENST00000546319.5
SLC6A13
solute carrier family 6 member 13
chr1_+_205256189 4.75 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr1_-_160031946 4.68 ENST00000368090.5
PIGM
phosphatidylinositol glycan anchor biosynthesis class M
chr22_-_50085414 4.64 ENST00000311597.10
MLC1
modulator of VRAC current 1
chr10_-_5977589 4.63 ENST00000620345.4
ENST00000397251.7
ENST00000397248.6
ENST00000622442.4
ENST00000620865.4
IL15RA
interleukin 15 receptor subunit alpha
chr5_+_141208697 4.60 ENST00000624949.1
ENST00000622978.1
ENST00000239450.4
PCDHB12
protocadherin beta 12
chr12_+_54280663 4.52 ENST00000677375.1
ENST00000677210.1
ENST00000677385.1
ENST00000677249.1
ENST00000550482.2
ENST00000679101.1
ENST00000340913.11
ENST00000547708.5
ENST00000551702.5
ENST00000676794.1
ENST00000330752.12
ENST00000678690.1
ENST00000678919.1
ENST00000547276.5
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr1_+_171248471 4.50 ENST00000402921.6
ENST00000617670.6
ENST00000367750.7
FMO1
flavin containing dimethylaniline monoxygenase 1
chr2_+_69915100 4.35 ENST00000264444.7
MXD1
MAX dimerization protein 1
chr3_-_115071333 4.24 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_89315291 4.21 ENST00000402938.4
GABRR2
gamma-aminobutyric acid type A receptor subunit rho2
chr22_-_23754376 4.15 ENST00000398465.3
ENST00000248948.4
VPREB3
V-set pre-B cell surrogate light chain 3
chr11_-_790062 4.05 ENST00000330106.5
CEND1
cell cycle exit and neuronal differentiation 1
chr1_+_156369202 3.97 ENST00000537040.6
RHBG
Rh family B glycoprotein
chr12_+_119593758 3.93 ENST00000426426.3
TMEM233
transmembrane protein 233
chr14_-_106875069 3.85 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr11_-_62754141 3.82 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
ZBTB3
zinc finger and BTB domain containing 3
chr12_-_89526253 3.68 ENST00000547474.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr2_+_202912214 3.68 ENST00000402905.7
ENST00000320443.12
ENST00000414490.5
ENST00000431787.5
ENST00000444724.5
ENST00000414857.5
ENST00000438828.4
ENST00000430899.5
ENST00000445120.5
ENST00000441569.5
ENST00000432024.5
ENST00000443740.5
ENST00000414439.5
ENST00000428585.5
ENST00000447539.5
ENST00000434998.5
CARF
calcium responsive transcription factor
chr19_-_49024333 3.53 ENST00000357383.4
CGB3
chorionic gonadotropin subunit beta 3
chr16_-_23713197 3.48 ENST00000256797.9
ENST00000457008.6
ERN2
endoplasmic reticulum to nucleus signaling 2
chr12_-_89526164 3.47 ENST00000548729.5
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr8_-_100559702 3.40 ENST00000520311.5
ENST00000520552.5
ENST00000521345.1
ENST00000523000.5
ENST00000335659.7
ENST00000358990.3
ENST00000519597.5
ANKRD46
ankyrin repeat domain 46
chr11_-_61920267 3.40 ENST00000531922.2
ENST00000301773.9
RAB3IL1
RAB3A interacting protein like 1
chr10_+_18340821 3.39 ENST00000612743.1
ENST00000612134.4
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr14_-_106211453 3.31 ENST00000390606.3
IGHV3-20
immunoglobulin heavy variable 3-20
chr21_-_29939532 3.21 ENST00000327783.8
ENST00000389124.6
ENST00000389125.7
ENST00000399913.5
GRIK1
glutamate ionotropic receptor kainate type subunit 1
chr17_-_36534883 3.20 ENST00000620640.4
MYO19
myosin XIX
chr5_+_75611182 3.18 ENST00000672850.1
ENST00000672844.1
ANKDD1B
ankyrin repeat and death domain containing 1B
chr15_-_65286837 3.13 ENST00000444347.2
ENST00000261888.10
ENST00000649807.2
PARP16
poly(ADP-ribose) polymerase family member 16
chr11_+_63369779 3.11 ENST00000279178.4
SLC22A9
solute carrier family 22 member 9
chrX_+_10156960 3.08 ENST00000380833.9
CLCN4
chloride voltage-gated channel 4
chr1_-_77979054 3.04 ENST00000370768.7
ENST00000370767.5
ENST00000421641.1
FUBP1
far upstream element binding protein 1
chr11_+_57597563 3.01 ENST00000619430.2
ENST00000457869.1
ENST00000340687.10
ENST00000278407.9
ENST00000378323.8
ENST00000378324.6
ENST00000403558.1
SERPING1
serpin family G member 1
chr12_-_7936177 3.00 ENST00000544291.1
ENST00000075120.12
SLC2A3
solute carrier family 2 member 3
chr7_-_91880672 3.00 ENST00000456229.1
ENST00000442961.1
ENST00000406735.6
ENST00000419292.1
ENST00000351870.8
MTERF1
mitochondrial transcription termination factor 1
chr8_-_42541898 2.99 ENST00000342228.7
SLC20A2
solute carrier family 20 member 2
chr15_-_40828699 2.96 ENST00000299174.10
ENST00000427255.2
PPP1R14D
protein phosphatase 1 regulatory inhibitor subunit 14D
chr6_-_33009568 2.96 ENST00000374813.1
ENST00000229829.7
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr17_-_36534927 2.90 ENST00000610930.4
MYO19
myosin XIX
chr5_-_131994225 2.89 ENST00000543479.5
ENST00000431707.5
ACSL6
acyl-CoA synthetase long chain family member 6
chr10_+_18340699 2.84 ENST00000377329.10
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr10_-_72626111 2.80 ENST00000604238.2
ENST00000642044.1
ENST00000635239.1
ENST00000398761.8
MICU1
mitochondrial calcium uptake 1
chr15_+_81182579 2.77 ENST00000302987.9
IL16
interleukin 16
chr12_-_55842927 2.77 ENST00000322569.9
ENST00000409200.7
MMP19
matrix metallopeptidase 19
chr12_-_43758748 2.73 ENST00000416848.6
ENST00000550784.5
ENST00000547156.1
ENST00000549868.1
ENST00000551923.5
ENST00000344862.10
ENST00000431332.7
PUS7L
pseudouridine synthase 7 like
chrY_-_23694579 2.68 ENST00000343584.10
PRYP3
PTPN13 like Y-linked pseudogene 3
chr17_-_36534841 2.63 ENST00000614623.5
ENST00000621344.4
MYO19
myosin XIX
chr3_-_48089203 2.61 ENST00000468075.2
ENST00000360240.10
MAP4
microtubule associated protein 4
chr10_-_5978022 2.56 ENST00000525219.6
IL15RA
interleukin 15 receptor subunit alpha
chr3_+_186717348 2.44 ENST00000447445.1
ENST00000287611.8
ENST00000644859.2
KNG1
kininogen 1
chr7_+_111091119 2.42 ENST00000308478.10
LRRN3
leucine rich repeat neuronal 3
chr12_+_4720395 2.41 ENST00000252318.7
GALNT8
polypeptide N-acetylgalactosaminyltransferase 8
chr11_-_66593031 2.36 ENST00000333861.5
CCDC87
coiled-coil domain containing 87
chr6_+_125781108 2.34 ENST00000368357.7
NCOA7
nuclear receptor coactivator 7
chr1_+_169367934 2.34 ENST00000367807.7
ENST00000329281.6
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr11_+_118883884 2.26 ENST00000292174.5
CXCR5
C-X-C motif chemokine receptor 5
chr19_+_55385928 2.25 ENST00000431533.6
ENST00000428193.6
ENST00000558815.5
ENST00000344063.7
ENST00000560583.5
ENST00000560055.5
ENST00000559463.5
RPL28
ribosomal protein L28
chr7_+_128476748 2.23 ENST00000262432.13
ENST00000480046.5
METTL2B
methyltransferase like 2B
chr2_+_102311546 2.15 ENST00000233954.6
ENST00000447231.5
IL1RL1
interleukin 1 receptor like 1
chr22_+_29205877 2.14 ENST00000334018.11
ENST00000429226.5
ENST00000404755.7
ENST00000404820.7
ENST00000430127.1
EMID1
EMI domain containing 1
chr7_+_111091006 2.13 ENST00000451085.5
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chr6_-_34696733 2.11 ENST00000374023.8
ILRUN
inflammation and lipid regulator with UBA-like and NBR1-like domains
chr6_-_34696839 2.10 ENST00000374026.7
ILRUN
inflammation and lipid regulator with UBA-like and NBR1-like domains
chr19_-_10565990 2.09 ENST00000539027.5
ENST00000312962.12
ENST00000543682.3
ENST00000652042.1
ENST00000432197.5
KRI1
KRI1 homolog
chr1_+_196943738 2.07 ENST00000367415.8
ENST00000367421.5
ENST00000649283.1
ENST00000476712.6
ENST00000496448.6
ENST00000473386.1
ENST00000649960.1
CFHR2
complement factor H related 2
chr5_-_111756245 2.06 ENST00000447165.6
NREP
neuronal regeneration related protein
chr7_-_30682473 2.00 ENST00000506074.6
CRHR2
corticotropin releasing hormone receptor 2
chr16_-_1230089 1.99 ENST00000612142.1
ENST00000606293.5
TPSB2
tryptase beta 2
chr2_+_48568981 1.99 ENST00000394754.5
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr19_+_51571249 1.98 ENST00000262259.7
ENST00000545217.5
ENST00000596504.1
ZNF175
zinc finger protein 175
chr5_-_177783398 1.95 ENST00000510276.5
FAM153A
family with sequence similarity 153 member A
chr9_+_113501359 1.86 ENST00000343817.9
ENST00000394646.7
RGS3
regulator of G protein signaling 3
chr17_-_46818680 1.79 ENST00000225512.6
WNT3
Wnt family member 3
chr4_+_119027335 1.78 ENST00000627783.2
SYNPO2
synaptopodin 2
chr4_-_185395882 1.77 ENST00000505916.6
LRP2BP
LRP2 binding protein
chr17_+_60677822 1.62 ENST00000407086.8
ENST00000589222.5
ENST00000626960.2
ENST00000390652.9
BCAS3
BCAS3 microtubule associated cell migration factor
chr14_+_31025634 1.61 ENST00000673317.1
ENST00000556232.6
ENST00000542754.7
ENST00000554345.6
ENST00000334725.8
ENST00000554609.6
ENST00000313566.11
AP4S1
adaptor related protein complex 4 subunit sigma 1
chr6_+_31571957 1.59 ENST00000454783.5
LTA
lymphotoxin alpha
chr21_-_29019314 1.58 ENST00000493196.2
RWDD2B
RWD domain containing 2B
chr11_-_65857007 1.53 ENST00000527344.5
CFL1
cofilin 1
chr3_-_46208304 1.48 ENST00000296140.4
CCR1
C-C motif chemokine receptor 1
chr9_-_33402449 1.44 ENST00000377425.8
AQP7
aquaporin 7
chr9_+_122371036 1.44 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr3_+_171843337 1.43 ENST00000334567.9
ENST00000619900.4
ENST00000450693.1
TMEM212
transmembrane protein 212
chr11_-_111512339 1.41 ENST00000525791.5
ENST00000456861.2
ENST00000356018.6
BTG4
BTG anti-proliferation factor 4
chr22_-_38084093 1.41 ENST00000681075.1
SLC16A8
solute carrier family 16 member 8
chr3_-_123620571 1.38 ENST00000583087.5
MYLK
myosin light chain kinase
chr12_+_43758936 1.38 ENST00000440781.6
ENST00000431837.5
ENST00000550616.5
ENST00000613694.5
ENST00000551736.5
IRAK4
interleukin 1 receptor associated kinase 4
chr5_+_148063971 1.37 ENST00000398454.5
ENST00000359874.7
ENST00000508733.5
ENST00000256084.8
SPINK5
serine peptidase inhibitor Kazal type 5
chr3_-_123620496 1.32 ENST00000578202.1
MYLK
myosin light chain kinase
chr10_-_100081854 1.31 ENST00000370418.8
CPN1
carboxypeptidase N subunit 1
chr9_+_122370523 1.30 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr4_-_48080172 1.26 ENST00000507351.1
TXK
TXK tyrosine kinase
chr17_+_62423891 1.24 ENST00000616852.1
ENST00000311506.10
METTL2A
methyltransferase like 2A
chr11_-_76669985 1.22 ENST00000407242.6
ENST00000421973.1
LRRC32
leucine rich repeat containing 32
chr1_-_20786610 1.19 ENST00000375000.5
ENST00000312239.10
ENST00000419490.5
ENST00000414993.1
ENST00000443615.1
HP1BP3
heterochromatin protein 1 binding protein 3
chr11_+_99021066 1.19 ENST00000527185.5
ENST00000528682.5
CNTN5
contactin 5
chr1_+_21468442 1.17 ENST00000619554.1
NBPF3
NBPF member 3
chr11_-_65856944 1.15 ENST00000524553.5
CFL1
cofilin 1
chr2_-_69643152 1.14 ENST00000606389.7
AAK1
AP2 associated kinase 1
chr12_+_54280842 1.14 ENST00000678077.1
ENST00000548688.5
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr1_+_28369705 1.12 ENST00000373839.8
PHACTR4
phosphatase and actin regulator 4
chr1_+_203128279 1.05 ENST00000367235.1
ENST00000618295.1
ADORA1
adenosine A1 receptor
chr13_+_48653921 1.05 ENST00000682523.1
CYSLTR2
cysteinyl leukotriene receptor 2
chr11_-_64759967 1.04 ENST00000377432.7
ENST00000164139.4
PYGM
glycogen phosphorylase, muscle associated
chr1_+_16440700 0.94 ENST00000504551.6
ENST00000457722.6
ENST00000337132.10
ENST00000443980.6
NECAP2
NECAP endocytosis associated 2
chr5_+_108747879 0.92 ENST00000281092.9
FER
FER tyrosine kinase
chr3_+_122055355 0.89 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86
CD86 molecule
chr17_+_4932248 0.88 ENST00000329125.6
GP1BA
glycoprotein Ib platelet subunit alpha
chr1_-_68050615 0.87 ENST00000646789.1
DIRAS3
DIRAS family GTPase 3
chr4_+_69280472 0.85 ENST00000335568.10
ENST00000511240.1
UGT2B28
UDP glucuronosyltransferase family 2 member B28
chrX_+_30243715 0.85 ENST00000378981.8
ENST00000397550.6
MAGEB1
MAGE family member B1
chr2_+_102311502 0.81 ENST00000404917.6
ENST00000410040.5
IL1RL1
IL18R1
interleukin 1 receptor like 1
interleukin 18 receptor 1
chr14_+_20768393 0.78 ENST00000326783.4
EDDM3B
epididymal protein 3B
chr15_+_43133546 0.77 ENST00000260403.7
TMEM62
transmembrane protein 62
chr17_-_64497025 0.71 ENST00000539111.7
POLG2
DNA polymerase gamma 2, accessory subunit
chr14_+_64715677 0.67 ENST00000634379.2
PLEKHG3
pleckstrin homology and RhoGEF domain containing G3
chr1_+_203127678 0.67 ENST00000640524.1
ENST00000337894.9
ADORA1
adenosine A1 receptor
chr3_+_122077776 0.62 ENST00000264468.9
CD86
CD86 molecule
chr19_-_49036885 0.59 ENST00000604577.1
ENST00000591656.1
ENST00000301407.8
ENST00000601167.1
ENSG00000267335.2
CGB1
novel protein
chorionic gonadotropin subunit beta 1
chr1_-_109613070 0.58 ENST00000351050.8
GNAT2
G protein subunit alpha transducin 2
chr1_+_173824626 0.57 ENST00000648960.1
ENST00000648807.1
ENST00000649067.1
ENST00000649689.2
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr15_-_28099293 0.53 ENST00000431101.1
ENST00000445578.5
ENST00000353809.9
ENST00000354638.8
OCA2
OCA2 melanosomal transmembrane protein
chr6_+_29396555 0.50 ENST00000623183.1
OR12D2
olfactory receptor family 12 subfamily D member 2
chr1_-_19251509 0.50 ENST00000375199.7
ENST00000375208.7
ENST00000477853.6
EMC1
ER membrane protein complex subunit 1
chr11_+_99020940 0.48 ENST00000524871.6
CNTN5
contactin 5
chr3_+_122077850 0.46 ENST00000482356.5
ENST00000393627.6
CD86
CD86 molecule
chr20_+_56392607 0.40 ENST00000217109.9
ENST00000452950.1
CSTF1
cleavage stimulation factor subunit 1
chr11_+_27040725 0.39 ENST00000529202.5
ENST00000263182.8
BBOX1
gamma-butyrobetaine hydroxylase 1
chr1_+_173824694 0.29 ENST00000647645.1
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chrX_-_47482529 0.27 ENST00000313116.11
ZNF41
zinc finger protein 41
chr2_+_70978380 0.26 ENST00000272421.10
ENST00000441349.5
ENST00000457410.5
ANKRD53
ankyrin repeat domain 53
chr8_-_94208548 0.24 ENST00000027335.8
ENST00000441892.6
ENST00000521491.1
CDH17
cadherin 17
chr7_+_31687208 0.20 ENST00000409146.3
ENST00000342032.8
PPP1R17
protein phosphatase 1 regulatory subunit 17
chr17_-_49646581 0.19 ENST00000510476.5
ENST00000503676.5
SPOP
speckle type BTB/POZ protein
chr9_-_33402551 0.08 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
AQP7
aquaporin 7
chr17_-_3063607 0.08 ENST00000575751.1
OR1D5
olfactory receptor family 1 subfamily D member 5
chr17_+_4932285 0.08 ENST00000611961.1
GP1BA
glycoprotein Ib platelet subunit alpha
chr1_-_28058087 0.05 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.3 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
5.9 17.8 GO:0071461 cellular response to redox state(GO:0071461)
2.6 7.7 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
2.4 12.0 GO:0030070 insulin processing(GO:0030070)
2.1 8.4 GO:0006258 UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879) negative regulation of type B pancreatic cell development(GO:2000077)
1.6 6.3 GO:0061528 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
1.4 21.7 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
1.4 14.0 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.3 22.8 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
1.3 4.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
1.3 6.5 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
1.1 12.2 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
1.0 3.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
1.0 3.0 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.0 3.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
1.0 17.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.0 3.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
1.0 15.7 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.9 5.7 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.9 4.7 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.9 6.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.8 59.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.7 11.1 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.7 8.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.7 8.6 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.7 2.0 GO:0043017 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.6 1.8 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.6 1.7 GO:0070256 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.6 4.5 GO:0070995 NADPH oxidation(GO:0070995)
0.5 8.2 GO:0006600 creatine metabolic process(GO:0006600)
0.5 7.0 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.5 2.7 GO:2000771 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.5 1.6 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.5 5.5 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.5 17.3 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.5 1.4 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.4 2.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 4.4 GO:0032264 IMP salvage(GO:0032264)
0.4 2.6 GO:0051012 microtubule sliding(GO:0051012)
0.4 3.0 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.4 3.7 GO:0035865 cellular response to potassium ion(GO:0035865)
0.4 3.1 GO:0015747 urate transport(GO:0015747)
0.4 3.5 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.4 1.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.4 6.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.3 2.8 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.3 2.8 GO:0001554 luteolysis(GO:0001554)
0.3 1.3 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.3 7.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.3 3.0 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 12.8 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.3 2.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.3 4.9 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.3 0.9 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.3 4.9 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.3 3.0 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.3 1.5 GO:0015793 glycerol transport(GO:0015793)
0.2 4.7 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.2 0.9 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.2 2.0 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 8.7 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.2 0.5 GO:0043474 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.2 1.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.2 2.7 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 3.5 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.7 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 3.4 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 2.8 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 2.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 22.2 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.1 2.3 GO:0048535 lymph node development(GO:0048535)
0.1 2.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.5 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.1 1.1 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.1 4.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 5.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 7.6 GO:0006968 cellular defense response(GO:0006968)
0.1 4.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.0 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1 2.9 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 3.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 3.1 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 0.6 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.1 3.5 GO:0016486 peptide hormone processing(GO:0016486)
0.1 7.9 GO:0007286 spermatid development(GO:0007286)
0.1 9.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.2 GO:0070828 heterochromatin organization(GO:0070828)
0.1 4.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 2.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 2.4 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.1 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 1.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 2.2 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 9.7 GO:0006959 humoral immune response(GO:0006959)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.3 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.9 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 1.0 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 1.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 1.8 GO:0000045 autophagosome assembly(GO:0000045)
0.0 1.2 GO:0050710 negative regulation of cytokine secretion(GO:0050710)
0.0 0.6 GO:0030728 ovulation(GO:0030728)
0.0 5.0 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.0 16.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 15.7 GO:0072534 perineuronal net(GO:0072534)
1.6 6.3 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
1.3 7.7 GO:0045298 tubulin complex(GO:0045298)
1.1 21.2 GO:0042613 MHC class II protein complex(GO:0042613)
1.1 59.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.7 2.8 GO:1990246 uniplex complex(GO:1990246)
0.7 3.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.4 8.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 7.9 GO:0097440 apical dendrite(GO:0097440)
0.3 6.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 1.8 GO:1990909 Wnt signalosome(GO:1990909)
0.2 14.0 GO:0043034 costamere(GO:0043034)
0.2 7.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 17.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.2 1.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 4.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 4.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 4.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.2 GO:0000786 nucleosome(GO:0000786)
0.1 3.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 8.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 10.5 GO:0005884 actin filament(GO:0005884)
0.1 17.3 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 32.2 GO:0097060 synaptic membrane(GO:0097060)
0.1 4.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 7.1 GO:0016459 myosin complex(GO:0016459)
0.1 7.5 GO:0005901 caveola(GO:0005901)
0.1 1.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 2.1 GO:0005581 collagen trimer(GO:0005581)
0.1 5.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 4.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.6 GO:0031904 endosome lumen(GO:0031904)
0.1 2.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 5.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 19.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 10.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.6 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 4.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 48.9 GO:0005615 extracellular space(GO:0005615)
0.0 43.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.1 GO:0043195 terminal bouton(GO:0043195)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.2 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
2.2 17.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.1 8.6 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.9 7.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.6 17.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.6 6.3 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
1.5 7.7 GO:0031871 proteinase activated receptor binding(GO:0031871)
1.5 21.2 GO:0032395 MHC class II receptor activity(GO:0032395)
1.4 5.7 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
1.4 12.2 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
1.1 8.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
1.0 3.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
1.0 19.8 GO:0005522 profilin binding(GO:0005522)
1.0 4.9 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.0 3.0 GO:0002113 interleukin-33 binding(GO:0002113)
1.0 59.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.7 3.5 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.7 21.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.7 2.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.6 4.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.6 10.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.6 4.9 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.6 3.0 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.5 1.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.5 2.0 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.5 4.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.5 6.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.5 2.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 6.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.4 1.5 GO:0015254 glycerol channel activity(GO:0015254)
0.4 3.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 3.1 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 1.7 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.3 5.5 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.3 8.2 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 8.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.3 1.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.2 14.0 GO:0030507 spectrin binding(GO:0030507)
0.2 2.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 1.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 2.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 2.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 1.0 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 3.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 21.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 22.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 9.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 4.0 GO:0030506 ankyrin binding(GO:0030506)
0.1 7.9 GO:0015485 cholesterol binding(GO:0015485)
0.1 2.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 4.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 1.8 GO:0031005 filamin binding(GO:0031005)
0.1 3.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.8 GO:0048018 receptor agonist activity(GO:0048018)
0.1 9.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 13.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.2 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 1.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 3.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 10.6 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 4.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.0 GO:0015026 coreceptor activity(GO:0015026)
0.0 1.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 4.1 GO:0005179 hormone activity(GO:0005179)
0.0 2.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.9 GO:0000049 tRNA binding(GO:0000049)
0.0 2.7 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 5.3 GO:0008168 methyltransferase activity(GO:0008168)
0.0 4.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 16.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 27.1 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 6.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 21.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.4 46.0 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.3 2.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3 6.6 PID S1P S1P4 PATHWAY S1P4 pathway
0.3 8.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.3 17.7 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 17.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 4.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 7.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 2.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 2.7 SIG CHEMOTAXIS Genes related to chemotaxis
0.1 4.1 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 1.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 15.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 2.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.4 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 17.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.3 7.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.3 6.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 4.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 4.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 4.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 6.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 6.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 1.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 11.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.0 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 4.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 2.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.7 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 17.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.7 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 5.6 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.1 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 0.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 1.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 3.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 6.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 4.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 3.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT