Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for NR1D1

Z-value: 3.10

Motif logo

logo of

Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
NR1D1
ENSG00000126368.6 NR1D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg38_v1_chr17_-_40100569_401005970.491.9e-14Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_125496122 20.27 ENST00000527534.1
ENST00000278919.8
ENST00000366139.3
FEZ1
fasciculation and elongation protein zeta 1
chr8_-_109648825 14.21 ENST00000533895.5
ENST00000446070.6
ENST00000528331.5
ENST00000526302.5
ENST00000408908.6
ENST00000433638.1
ENST00000524720.5
SYBU
syntabulin
chr1_-_11805949 13.74 ENST00000376590.9
MTHFR
methylenetetrahydrofolate reductase
chr1_-_11805977 13.48 ENST00000376486.3
MTHFR
methylenetetrahydrofolate reductase
chr1_-_11805924 12.65 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase
chr1_-_25906931 11.43 ENST00000357865.6
STMN1
stathmin 1
chr8_+_104223320 10.60 ENST00000339750.3
RIMS2
regulating synaptic membrane exocytosis 2
chr13_+_112969179 10.55 ENST00000535094.7
MCF2L
MCF.2 cell line derived transforming sequence like
chr19_+_21020675 9.47 ENST00000595401.1
ZNF430
zinc finger protein 430
chr6_-_169250825 9.44 ENST00000676869.1
ENST00000676760.1
THBS2
thrombospondin 2
chr14_-_23301474 8.47 ENST00000561437.1
ENST00000559942.5
ENST00000560913.1
ENST00000559314.5
ENST00000558058.5
PPP1R3E
protein phosphatase 1 regulatory subunit 3E
chr8_+_104223344 7.91 ENST00000523362.5
RIMS2
regulating synaptic membrane exocytosis 2
chr13_+_112968496 7.89 ENST00000397030.5
MCF2L
MCF.2 cell line derived transforming sequence like
chr15_-_80989792 7.34 ENST00000261758.6
ENST00000561312.5
MESD
mesoderm development LRP chaperone
chr5_-_111976925 6.79 ENST00000395634.7
NREP
neuronal regeneration related protein
chr3_-_51968387 6.72 ENST00000490063.5
ENST00000468324.5
ENST00000497653.5
ENST00000484633.5
PCBP4
poly(rC) binding protein 4
chr19_-_23395418 6.63 ENST00000595533.1
ENST00000397082.2
ENST00000599743.5
ENST00000300619.12
ZNF91
zinc finger protein 91
chr7_+_94509793 6.32 ENST00000297273.9
CASD1
CAS1 domain containing 1
chr2_+_112584586 6.24 ENST00000409719.1
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chrX_+_54920796 6.12 ENST00000442098.5
ENST00000430420.5
ENST00000453081.5
ENST00000319167.12
ENST00000622017.4
ENST00000375022.8
ENST00000399736.5
ENST00000440072.5
ENST00000173898.12
ENST00000431115.5
ENST00000440759.5
ENST00000375041.6
TRO
trophinin
chr8_-_144475808 6.06 ENST00000377317.5
FOXH1
forkhead box H1
chr14_+_24070837 5.71 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
CPNE6
copine 6
chr9_+_101028721 5.49 ENST00000374874.8
PLPPR1
phospholipid phosphatase related 1
chr1_-_11805294 5.28 ENST00000413656.5
ENST00000376592.6
ENST00000376585.6
MTHFR
methylenetetrahydrofolate reductase
chr3_+_58237773 5.28 ENST00000478253.6
ABHD6
abhydrolase domain containing 6, acylglycerol lipase
chr19_+_21082140 5.02 ENST00000616183.1
ENST00000596053.5
ZNF714
zinc finger protein 714
chr1_+_109712272 4.90 ENST00000369812.6
GSTM5
glutathione S-transferase mu 5
chr9_+_35490103 4.86 ENST00000361226.8
RUSC2
RUN and SH3 domain containing 2
chr18_-_46757012 4.53 ENST00000315087.12
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr16_+_71358713 4.42 ENST00000349553.9
ENST00000302628.9
ENST00000562305.5
CALB2
calbindin 2
chr17_-_39918589 4.25 ENST00000309481.11
GSDMB
gasdermin B
chr17_-_39918606 3.82 ENST00000418519.6
ENST00000520542.5
GSDMB
gasdermin B
chr5_-_43313473 3.79 ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr1_+_109712227 3.78 ENST00000256593.8
GSTM5
glutathione S-transferase mu 5
chr1_-_25905989 3.78 ENST00000399728.5
STMN1
stathmin 1
chr2_-_102736819 3.60 ENST00000258436.10
MFSD9
major facilitator superfamily domain containing 9
chr19_-_57559833 3.56 ENST00000457177.5
ZNF550
zinc finger protein 550
chr16_-_18375069 3.54 ENST00000545114.5
NPIPA9
nuclear pore complex interacting protein family, member A9
chr2_+_63588953 3.51 ENST00000409908.5
ENST00000442225.5
ENST00000233114.13
ENST00000539945.7
ENST00000409476.5
ENST00000436321.5
MDH1
malate dehydrogenase 1
chr17_-_40100569 3.49 ENST00000246672.4
NR1D1
nuclear receptor subfamily 1 group D member 1
chr17_+_50560703 3.43 ENST00000359106.10
CACNA1G
calcium voltage-gated channel subunit alpha1 G
chr19_+_21082190 3.42 ENST00000618422.1
ENST00000618008.4
ENST00000425625.5
ENST00000456283.7
ZNF714
zinc finger protein 714
chr19_-_38315919 3.36 ENST00000591755.5
ENST00000337679.12
ENST00000339413.11
YIF1B
Yip1 interacting factor homolog B, membrane trafficking protein
chr8_+_11704151 3.36 ENST00000526716.5
ENST00000532059.6
ENST00000335135.8
ENST00000622443.3
GATA4
GATA binding protein 4
chr7_-_129055158 3.34 ENST00000627585.2
TNPO3
transportin 3
chr15_+_65611336 3.33 ENST00000537259.5
SLC24A1
solute carrier family 24 member 1
chr19_-_42423100 3.27 ENST00000597001.1
LIPE
lipase E, hormone sensitive type
chr5_-_43313403 3.18 ENST00000325110.11
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr6_+_75749272 3.00 ENST00000653423.1
MYO6
myosin VI
chr6_+_13574227 2.95 ENST00000680432.1
ENST00000681012.1
ENST00000397350.7
SIRT5
sirtuin 5
chr7_-_129055093 2.95 ENST00000482320.5
ENST00000265388.10
ENST00000471234.5
TNPO3
transportin 3
chr18_+_33578213 2.81 ENST00000681521.1
ENST00000269197.12
ASXL3
ASXL transcriptional regulator 3
chr17_+_6996042 2.76 ENST00000251535.11
ALOX12
arachidonate 12-lipoxygenase, 12S type
chr19_-_4455292 2.61 ENST00000394765.7
ENST00000592515.1
UBXN6
UBX domain protein 6
chr11_+_60924452 2.42 ENST00000453848.7
ENST00000544065.5
ENST00000005286.8
TMEM132A
transmembrane protein 132A
chr19_+_21142024 2.41 ENST00000600692.5
ENST00000599296.5
ENST00000594425.5
ENST00000311048.11
ZNF431
zinc finger protein 431
chr15_-_65611110 2.41 ENST00000567744.5
ENST00000568573.1
ENST00000562830.1
ENST00000569491.5
ENST00000561769.1
INTS14
integrator complex subunit 14
chr1_-_25906411 2.41 ENST00000455785.7
STMN1
stathmin 1
chr3_-_45915698 2.37 ENST00000539217.5
LZTFL1
leucine zipper transcription factor like 1
chr11_+_46719193 2.25 ENST00000311907.10
ENST00000530231.5
ENST00000442468.1
F2
coagulation factor II, thrombin
chrX_-_49233309 2.24 ENST00000376251.5
ENST00000323022.10
ENST00000376265.2
CACNA1F
calcium voltage-gated channel subunit alpha1 F
chr2_+_63589135 2.22 ENST00000432309.6
MDH1
malate dehydrogenase 1
chr9_-_33167296 2.19 ENST00000379731.5
ENST00000535206.5
B4GALT1
beta-1,4-galactosyltransferase 1
chr7_-_100896123 2.00 ENST00000428317.7
ACHE
acetylcholinesterase (Cartwright blood group)
chr6_+_75749231 1.98 ENST00000664209.1
ENST00000369975.6
ENST00000627432.3
ENST00000369985.9
ENST00000369977.8
ENST00000664640.1
ENST00000662603.1
MYO6
myosin VI
chr22_-_37484505 1.92 ENST00000442496.1
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr22_+_45502832 1.92 ENST00000455233.5
ENST00000402984.7
ENST00000262722.11
ENST00000327858.11
ENST00000442170.6
ENST00000340923.9
FBLN1
fibulin 1
chr17_+_42854078 1.89 ENST00000591562.1
ENST00000588033.1
AOC3
amine oxidase copper containing 3
chr1_+_43933277 1.71 ENST00000414809.7
ARTN
artemin
chr6_+_167111789 1.50 ENST00000400926.5
CCR6
C-C motif chemokine receptor 6
chr15_-_65611236 1.49 ENST00000420799.7
ENST00000313182.6
ENST00000431261.6
ENST00000652388.1
ENST00000442903.3
INTS14
integrator complex subunit 14
chr11_-_18046262 1.47 ENST00000682019.1
TPH1
tryptophan hydroxylase 1
chr10_+_11005301 1.43 ENST00000416382.6
ENST00000631460.1
ENST00000631816.1
CELF2
CUGBP Elav-like family member 2
chr1_-_168543990 1.41 ENST00000367819.3
XCL2
X-C motif chemokine ligand 2
chr19_-_43204223 1.35 ENST00000599746.5
PSG4
pregnancy specific beta-1-glycoprotein 4
chr3_-_48685835 1.31 ENST00000439518.5
ENST00000416649.6
ENST00000294129.7
NCKIPSD
NCK interacting protein with SH3 domain
chr6_+_75749192 1.25 ENST00000369981.7
MYO6
myosin VI
chr7_-_100895878 1.20 ENST00000419336.6
ENST00000241069.11
ENST00000411582.4
ENST00000302913.8
ACHE
acetylcholinesterase (Cartwright blood group)
chr13_+_100089015 1.12 ENST00000376286.8
ENST00000376279.7
ENST00000376285.6
PCCA
propionyl-CoA carboxylase subunit alpha
chr16_+_77191173 1.04 ENST00000248248.8
ENST00000439557.6
ENST00000545553.1
MON1B
MON1 homolog B, secretory trafficking associated
chr11_+_66857056 0.96 ENST00000309602.5
ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr11_-_119381629 0.95 ENST00000260187.7
ENST00000455332.6
USP2
ubiquitin specific peptidase 2
chr1_+_2467437 0.89 ENST00000449969.5
PLCH2
phospholipase C eta 2
chr7_+_98106852 0.88 ENST00000297293.6
LMTK2
lemur tyrosine kinase 2
chr1_+_197413827 0.87 ENST00000367397.1
ENST00000681519.1
CRB1
crumbs cell polarity complex component 1
chr5_+_141150012 0.72 ENST00000231136.4
ENST00000622991.1
PCDHB6
protocadherin beta 6
chr19_+_21082224 0.67 ENST00000620627.1
ZNF714
zinc finger protein 714
chrX_+_16946862 0.51 ENST00000303843.7
REPS2
RALBP1 associated Eps domain containing 2
chr1_+_159826860 0.38 ENST00000289707.10
SLAMF8
SLAM family member 8
chr1_+_171090892 0.37 ENST00000367755.9
ENST00000479749.1
FMO3
flavin containing dimethylaniline monoxygenase 3
chr11_+_7513966 0.34 ENST00000299492.9
PPFIBP2
PPFIA binding protein 2
chr19_-_22422335 0.25 ENST00000357774.9
ENST00000601553.1
ENST00000593657.5
ZNF98
zinc finger protein 98
chr12_-_7018465 0.23 ENST00000261407.9
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr22_+_26621952 0.14 ENST00000354760.4
CRYBA4
crystallin beta A4
chr17_+_6070361 0.12 ENST00000317744.10
WSCD1
WSC domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 45.1 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
2.4 9.4 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
2.3 20.3 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
2.1 6.3 GO:0035048 splicing factor protein import into nucleus(GO:0035048)
2.1 18.5 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
1.4 16.9 GO:1905098 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
1.2 3.5 GO:0060086 circadian temperature homeostasis(GO:0060086)
1.1 3.2 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
1.0 2.9 GO:0061699 protein demalonylation(GO:0036046) peptidyl-lysine demalonylation(GO:0036047) protein desuccinylation(GO:0036048) peptidyl-lysine desuccinylation(GO:0036049) protein deglutarylation(GO:0061698) peptidyl-lysine deglutarylation(GO:0061699)
0.9 2.8 GO:2001303 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.8 2.4 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.7 2.2 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.7 10.3 GO:0009642 response to light intensity(GO:0009642)
0.6 1.9 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.6 5.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.5 3.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.5 5.7 GO:0006108 malate metabolic process(GO:0006108)
0.5 6.6 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.5 1.5 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.5 1.5 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.5 6.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.5 2.3 GO:1900738 cytolysis in other organism involved in symbiotic interaction(GO:0051801) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.3 1.7 GO:0097021 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.3 8.7 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.3 1.0 GO:0019086 late viral transcription(GO:0019086)
0.3 2.6 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.2 3.4 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.2 5.7 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 1.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.2 4.5 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688) sialylation(GO:0097503)
0.2 9.5 GO:0021762 substantia nigra development(GO:0021762)
0.1 12.2 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 2.2 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 8.0 GO:0007566 embryo implantation(GO:0007566)
0.1 1.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 5.5 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 9.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 18.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 6.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 8.5 GO:0005977 glycogen metabolic process(GO:0005977)
0.1 6.2 GO:0030330 DNA damage response, signal transduction by p53 class mediator(GO:0030330)
0.1 0.9 GO:0045475 locomotor rhythm(GO:0045475)
0.0 1.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.4 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.9 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.9 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 2.4 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 3.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.2 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 4.4 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.2 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.9 14.2 GO:0097433 dense body(GO:0097433)
0.3 6.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.3 18.5 GO:0048786 presynaptic active zone(GO:0048786)
0.3 11.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 2.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 3.2 GO:0043083 synaptic cleft(GO:0043083)
0.2 1.9 GO:0071953 elastic fiber(GO:0071953)
0.2 5.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 5.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 9.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 2.4 GO:0005921 gap junction(GO:0005921)
0.1 9.4 GO:0005604 basement membrane(GO:0005604)
0.1 33.9 GO:0005874 microtubule(GO:0005874)
0.1 5.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 3.3 GO:0005811 lipid particle(GO:0005811)
0.0 2.8 GO:0005902 microvillus(GO:0005902)
0.0 37.2 GO:0045202 synapse(GO:0045202)
0.0 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 5.7 GO:0043209 myelin sheath(GO:0043209)
0.0 2.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.8 GO:0042383 sarcolemma(GO:0042383)
0.0 2.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.3 GO:0019867 outer membrane(GO:0019867)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 45.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
2.3 7.0 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
2.1 6.2 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
1.1 5.7 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.1 3.4 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
1.1 3.3 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
1.0 2.9 GO:0061697 protein-malonyllysine demalonylase activity(GO:0036054) protein-succinyllysine desuccinylase activity(GO:0036055) protein-glutaryllysine deglutarylase activity(GO:0061697)
0.9 2.8 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.8 3.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.6 4.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.6 3.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.5 20.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.5 2.2 GO:0004461 lactose synthase activity(GO:0004461)
0.5 6.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.5 1.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.5 1.9 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.4 14.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 1.9 GO:0070051 fibrinogen binding(GO:0070051)
0.4 5.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577)
0.4 5.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 9.4 GO:0070410 co-SMAD binding(GO:0070410)
0.2 1.5 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 3.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 2.3 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.2 8.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 18.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 6.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 23.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 5.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.5 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 1.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.2 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 2.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 6.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 9.4 GO:0008201 heparin binding(GO:0008201)
0.0 15.7 GO:0015631 tubulin binding(GO:0015631)
0.0 1.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 2.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 16.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 18.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 3.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 9.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 6.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 7.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 6.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 6.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.8 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 45.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 8.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.3 6.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 4.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 7.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 6.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 2.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 1.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 3.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 3.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 5.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 3.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 5.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 9.4 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 11.6 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 3.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS