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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR1H4

Z-value: 8.54

Motif logo

Transcription factors associated with NR1H4

Gene Symbol Gene ID Gene Info
ENSG00000012504.15 NR1H4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1H4hg38_v1_chr12_+_100473951_100473972,
hg38_v1_chr12_+_100473708_100473874
0.351.7e-07Click!

Activity profile of NR1H4 motif

Sorted Z-values of NR1H4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr14_-_21024092 43.34 ENST00000554398.5
NDRG family member 2
chr14_-_21023954 43.15 ENST00000554094.5
NDRG family member 2
chr9_+_71911468 31.58 ENST00000377031.7
chromosome 9 open reading frame 85
chrX_+_103776493 28.59 ENST00000433491.5
ENST00000612423.4
ENST00000443502.5
proteolipid protein 1
chrX_+_103776831 27.58 ENST00000621218.5
ENST00000619236.1
proteolipid protein 1
chr12_+_57520959 19.16 ENST00000551351.5
methyl-CpG binding domain protein 6
chr12_-_57520480 18.48 ENST00000642841.1
ENST00000547303.5
ENST00000552740.5
ENST00000547526.1
ENST00000346473.8
ENST00000551116.5
novel protein
DNA damage inducible transcript 3
chr5_-_140564550 17.25 ENST00000357560.9
ENST00000358580.9
amyloid beta precursor protein binding family B member 3
chr3_-_57079287 16.01 ENST00000338458.8
ENST00000468727.5
Rho guanine nucleotide exchange factor 3
chr19_+_50203607 15.59 ENST00000642316.2
ENST00000425460.6
ENST00000440075.6
ENST00000376970.6
ENST00000599920.5
myosin heavy chain 14
chr11_+_45847406 15.39 ENST00000443527.6
ENST00000616623.4
ENST00000616080.2
cryptochrome circadian regulator 2
chr19_+_35138778 14.21 ENST00000351325.9
ENST00000586871.5
ENST00000592174.1
FXYD domain containing ion transport regulator 1
novel transcript
chr6_-_109094819 13.93 ENST00000436639.6
sestrin 1
chr17_-_8162932 13.69 ENST00000488857.5
ENST00000316509.11
ENST00000481878.1
ENST00000498285.1
vesicle associated membrane protein 2
novel protein
chr10_-_73874568 13.40 ENST00000322635.7
ENST00000322680.7
ENST00000394762.7
ENST00000680035.1
calcium/calmodulin dependent protein kinase II gamma
chr17_+_75979211 13.01 ENST00000397640.6
ENST00000588202.5
ENST00000590676.1
ENST00000586891.1
TEN1 subunit of CST complex
chr17_-_35063648 12.15 ENST00000394597.7
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr10_-_73874502 12.09 ENST00000372765.5
ENST00000351293.7
ENST00000441192.2
ENST00000423381.6
calcium/calmodulin dependent protein kinase II gamma
chr11_-_64744102 11.88 ENST00000431822.5
ENST00000394432.8
ENST00000377486.7
RAS guanyl releasing protein 2
chr3_+_197749855 11.71 ENST00000241502.9
forty-two-three domain containing 1
chr11_-_71928624 11.59 ENST00000533047.5
ENST00000529844.5
novel protein similar to transient receptor potential cation channel, subfamily C, member 2 TRPC2
chr22_+_31753867 11.57 ENST00000535622.6
ENST00000645693.1
ENST00000642974.1
ENST00000645711.1
ENST00000644331.1
ENST00000645560.1
ENST00000437411.6
ENST00000433147.2
ENST00000646755.1
ENST00000382112.8
ENST00000647438.1
ENST00000400248.7
ENST00000456178.6
ENST00000646969.1
ENST00000642696.1
ENST00000647343.1
ENST00000400242.8
ENST00000651528.2
ENST00000645015.1
ENST00000645564.1
ENST00000646465.1
ENST00000400249.7
DEP domain containing 5, GATOR1 subcomplex subunit
chr1_-_109042093 11.42 ENST00000369962.8
ENST00000357672.7
ENST00000531337.1
ENST00000529074.1
ENST00000369965.8
WD repeat domain 47
chr19_-_49808639 11.26 ENST00000529634.2
fuzzy planar cell polarity protein
chr9_+_71911615 11.17 ENST00000334731.7
ENST00000486911.2
chromosome 9 open reading frame 85
chr6_+_30626842 11.17 ENST00000318999.11
ENST00000376485.8
ENST00000330083.6
ENST00000319027.9
ENST00000376483.8
ENST00000329992.12
alpha tubulin acetyltransferase 1
chr5_+_141208697 10.72 ENST00000624949.1
ENST00000622978.1
ENST00000239450.4
protocadherin beta 12
chr19_-_18274411 10.43 ENST00000595654.6
ENST00000593659.5
ENST00000599528.1
ENST00000392413.5
ENST00000608950.1
ENST00000600328.7
ENST00000600359.7
ENST00000612316.4
IQ motif containing N
chr3_-_49120887 10.34 ENST00000453664.5
ENST00000398888.6
ubiquitin specific peptidase 19
chr19_+_1205761 10.32 ENST00000326873.12
ENST00000586243.5
serine/threonine kinase 11
chr8_-_56446572 10.05 ENST00000518974.5
ENST00000451791.7
ENST00000523051.5
ENST00000518770.1
proenkephalin
chr3_+_124384950 9.76 ENST00000683146.1
kalirin RhoGEF kinase
chr12_+_108880085 9.52 ENST00000228476.8
ENST00000547768.5
D-amino acid oxidase
chr9_-_71911183 9.40 ENST00000333421.7
abhydrolase domain containing 17B, depalmitoylase
chr1_-_109041986 9.39 ENST00000400794.7
ENST00000528747.1
ENST00000361054.7
WD repeat domain 47
chr18_+_56651335 9.35 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WD repeat domain 7
chr5_+_150190035 9.18 ENST00000230671.7
ENST00000524041.1
solute carrier family 6 member 7
chr3_-_49120785 9.18 ENST00000417901.5
ENST00000306026.5
ENST00000434032.6
ubiquitin specific peptidase 19
chr19_+_53869384 9.08 ENST00000391769.2
myeloid associated differentiation marker
chr9_-_89178810 9.04 ENST00000375835.9
SHC adaptor protein 3
chr11_-_71928437 8.96 ENST00000529513.5
novel protein similar to transient receptor potential cation channel, subfamily C, member 2 TRPC2
chr17_-_1179940 8.71 ENST00000302538.10
ABR activator of RhoGEF and GTPase
chr1_+_36224410 8.26 ENST00000469141.6
ENST00000648638.1
ENST00000354618.10
thyroid hormone receptor associated protein 3
chr13_+_30617902 8.21 ENST00000255304.9
ENST00000614860.1
ubiquitin specific peptidase like 1
chr1_+_25272492 8.10 ENST00000454452.6
Rh blood group D antigen
chr3_-_28348805 8.08 ENST00000457172.5
ENST00000479665.6
5-azacytidine induced 2
chr6_+_127266832 7.93 ENST00000356799.6
ENST00000368314.6
ring finger protein 146
chr19_-_633500 7.88 ENST00000588649.7
RNA polymerase mitochondrial
chr17_-_39607876 7.84 ENST00000302584.5
neuronal differentiation 2
chr9_-_134917872 7.69 ENST00000616356.4
ENST00000371806.4
ficolin 1
chr3_-_50345665 7.61 ENST00000442887.1
ENST00000231749.8
ENST00000360165.7
zinc finger MYND-type containing 10
chr17_-_42745025 7.61 ENST00000592492.5
ENST00000585893.5
ENST00000593214.5
ENST00000590078.5
ENST00000428826.7
ENST00000586382.5
ENST00000415827.6
ENST00000592743.5
ENST00000586089.5
enhancer of zeste 1 polycomb repressive complex 2 subunit
chr1_+_205257180 7.43 ENST00000330675.12
transmembrane and coiled-coil domain family 2
chr20_+_32052192 7.41 ENST00000375862.7
ENST00000629881.2
ENST00000375852.5
ENST00000520553.5
ENST00000518730.5
HCK proto-oncogene, Src family tyrosine kinase
chr14_-_24634266 7.39 ENST00000382540.5
granzyme B
chr13_-_32538819 7.38 ENST00000674452.1
ENST00000674422.1
ENST00000674349.1
ENST00000674465.1
ENST00000674327.1
ENST00000505213.5
ENST00000357505.10
ENST00000399396.7
NEDD4 binding protein 2 like 2
chr4_+_122152308 7.38 ENST00000679879.1
ENST00000264501.8
KIAA1109
chr14_-_24634160 7.32 ENST00000616551.1
ENST00000382542.5
ENST00000216341.9
ENST00000526004.1
ENST00000415355.7
granzyme B
chr19_+_1071194 7.29 ENST00000543365.5
Rho GTPase activating protein 45
chr5_-_16508951 7.26 ENST00000682628.1
reticulophagy regulator 1
chr1_-_158426237 7.19 ENST00000641042.1
olfactory receptor family 10 subfamily K member 2
chr5_-_16508858 7.12 ENST00000684456.1
reticulophagy regulator 1
chr3_+_124384757 7.09 ENST00000684374.1
kalirin RhoGEF kinase
chr19_+_10086305 7.05 ENST00000253110.16
ENST00000591813.5
shiftless antiviral inhibitor of ribosomal frameshifting
chr11_-_7020235 7.04 ENST00000536068.5
ENST00000278314.5
zinc finger protein 214
chr5_-_16508812 7.03 ENST00000683414.1
reticulophagy regulator 1
chr7_+_94509793 6.99 ENST00000297273.9
CAS1 domain containing 1
chr19_+_10086787 6.94 ENST00000590378.5
ENST00000397881.7
shiftless antiviral inhibitor of ribosomal frameshifting
chr5_-_16508990 6.71 ENST00000399793.6
reticulophagy regulator 1
chr3_-_120742506 6.68 ENST00000273375.8
ENST00000483733.1
RAB, member of RAS oncogene family like 3
chr22_+_30694851 6.64 ENST00000332585.11
oxysterol binding protein 2
chr1_+_28914597 6.59 ENST00000349460.9
erythrocyte membrane protein band 4.1
chr6_-_49713521 6.55 ENST00000339139.5
cysteine rich secretory protein 2
chr12_-_56333693 6.54 ENST00000425394.7
ENST00000548043.5
poly(A) specific ribonuclease subunit PAN2
chr6_+_127266875 6.33 ENST00000610162.5
ENST00000608991.5
ENST00000610153.1
ring finger protein 146
chr5_-_16508788 6.24 ENST00000682142.1
reticulophagy regulator 1
chr17_-_45490696 6.24 ENST00000430334.8
ENST00000584420.1
ENST00000589780.5
pleckstrin homology and RUN domain containing M1
chr12_-_56333893 6.23 ENST00000547572.1
ENST00000257931.9
ENST00000610546.4
ENST00000440411.7
poly(A) specific ribonuclease subunit PAN2
chr20_+_63738270 6.23 ENST00000467211.1
novel transcript, LIME1-SLC2A4RG readthrough
chr1_+_28914515 6.01 ENST00000644600.1
ENST00000643173.1
ENST00000648181.1
ENST00000650265.1
ENST00000644780.1
ENST00000343067.9
ENST00000643604.1
ENST00000373797.2
erythrocyte membrane protein band 4.1
chr19_-_35812838 6.01 ENST00000653904.2
proline dehydrogenase 2
chr3_+_124384513 5.98 ENST00000682540.1
ENST00000522553.6
ENST00000682695.1
ENST00000682674.1
ENST00000684382.1
kalirin RhoGEF kinase
chr3_-_15333152 5.97 ENST00000426925.5
SH3 domain binding protein 5
chr10_-_93601228 5.92 ENST00000371464.8
retinol binding protein 4
chr17_-_64130125 5.79 ENST00000680433.1
ENST00000433197.4
endoplasmic reticulum to nucleus signaling 1
chr17_+_61452378 5.79 ENST00000589003.5
ENST00000644296.1
T-box transcription factor 4
chr14_+_76761453 5.77 ENST00000167106.9
vasohibin 1
chr14_+_85533167 5.77 ENST00000682132.1
fibronectin leucine rich transmembrane protein 2
chr22_+_30694886 5.74 ENST00000446658.6
oxysterol binding protein 2
chr6_-_32192630 5.71 ENST00000375040.8
G protein signaling modulator 3
chrX_-_50200358 5.65 ENST00000437370.2
ENST00000376064.7
ENST00000448865.5
A-kinase anchoring protein 4
chr17_-_75261586 5.63 ENST00000580799.2
ENST00000538886.5
ENST00000537686.6
golgi associated, gamma adaptin ear containing, ARF binding protein 3
chr3_+_111542178 5.52 ENST00000283285.10
ENST00000352690.9
CD96 molecule
chr3_+_184337591 5.46 ENST00000383847.7
family with sequence similarity 131 member A
chr8_-_100309368 5.36 ENST00000523167.1
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr11_-_707063 5.00 ENST00000683307.1
DEAF1 transcription factor
chr2_+_218568809 4.75 ENST00000273064.11
CCR4-NOT transcription complex subunit 9
chr7_+_49773632 4.70 ENST00000340652.5
von Willebrand factor C domain containing 2
chr17_-_75979117 4.40 ENST00000301608.8
ENST00000293217.10
ENST00000588176.5
acyl-CoA oxidase 1
chr19_-_18542971 4.33 ENST00000596558.6
FKBP prolyl isomerase 8
chr1_+_27879638 4.33 ENST00000456990.1
thymocyte selection associated family member 2
chr15_-_73368951 4.28 ENST00000261917.4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
chr1_+_25272439 4.24 ENST00000648012.1
Rh blood group D antigen
chr18_-_69956924 4.24 ENST00000581982.5
ENST00000280200.8
CD226 molecule
chr19_-_1021114 4.22 ENST00000333175.9
ENST00000356663.8
transmembrane protein 259
chr21_-_45287878 4.19 ENST00000349485.10
ENST00000612472.4
ENST00000331343.11
protein O-fucosyltransferase 2
chr19_+_35748549 4.12 ENST00000301159.14
lin-37 DREAM MuvB core complex component
chr17_-_28552549 4.02 ENST00000581945.1
ENST00000444148.1
ENST00000335765.9
ENST00000301032.8
unc-119 lipid binding chaperone
chr1_-_26913964 3.99 ENST00000254227.4
nuclear receptor subfamily 0 group B member 2
chr2_+_218568558 3.98 ENST00000627282.2
ENST00000542068.5
CCR4-NOT transcription complex subunit 9
chr1_+_202348687 3.96 ENST00000608999.6
ENST00000391959.5
ENST00000480184.5
protein phosphatase 1 regulatory subunit 12B
chr2_-_178072751 3.89 ENST00000286063.11
phosphodiesterase 11A
chr19_-_18543556 3.80 ENST00000544835.7
ENST00000608443.6
ENST00000597960.7
FKBP prolyl isomerase 8
chr19_-_18543483 3.78 ENST00000597547.1
ENST00000222308.8
FKBP prolyl isomerase 8
chr5_-_177996242 3.77 ENST00000308304.2
PROP paired-like homeobox 1
chr19_+_589873 3.71 ENST00000251287.3
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
chr10_-_118046574 3.62 ENST00000369199.5
RAB11 family interacting protein 2
chr17_-_10036741 3.61 ENST00000585266.5
growth arrest specific 7
chr11_-_89491320 3.54 ENST00000534731.5
ENST00000527626.5
ENST00000525196.5
ENST00000263317.9
NADPH oxidase 4
chr17_-_46818680 3.52 ENST00000225512.6
Wnt family member 3
chr3_+_184155451 3.35 ENST00000431765.6
dishevelled segment polarity protein 3
chr11_+_113314569 3.32 ENST00000429951.5
ENST00000442859.5
ENST00000531164.5
ENST00000529850.5
ENST00000529221.6
ENST00000525965.5
tetratricopeptide repeat domain 12
chr17_+_45241067 3.31 ENST00000587489.5
formin like 1
chr14_+_23555983 3.27 ENST00000404535.3
thiamine triphosphatase
chr12_+_51912329 3.26 ENST00000547400.5
ENST00000550683.5
ENST00000419526.6
activin A receptor like type 1
chr12_-_57742120 3.22 ENST00000257897.7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr14_+_23556253 3.20 ENST00000556015.5
ENST00000554970.1
ENST00000288014.7
ENST00000554789.1
thiamine triphosphatase
chr2_+_86942118 3.17 ENST00000641458.2
RANBP2 like and GRIP domain containing 1
chr1_+_25272502 3.17 ENST00000328664.9
Rh blood group D antigen
chr6_-_33803980 2.99 ENST00000507738.1
ENST00000266003.9
ENST00000430124.7
motilin
chr1_+_12063357 2.97 ENST00000417814.3
TNF receptor superfamily member 8
chr11_+_113314811 2.94 ENST00000393020.5
tetratricopeptide repeat domain 12
chr7_-_150341615 2.94 ENST00000223271.8
ENST00000466675.5
ENST00000482669.1
ENST00000467793.5
retinoic acid receptor responder 2
chr11_+_67483119 2.87 ENST00000682659.1
ENST00000525341.2
aryl hydrocarbon receptor interacting protein
chr1_+_25272479 2.86 ENST00000622561.4
Rh blood group D antigen
chr3_+_50569470 2.84 ENST00000455834.5
ENST00000232854.9
HemK methyltransferase family member 1
chr3_+_186842687 2.82 ENST00000444204.2
ENST00000320741.7
adiponectin, C1Q and collagen domain containing
chr12_+_6789508 2.76 ENST00000011653.9
ENST00000541982.5
ENST00000539492.1
CD4 molecule
chrX_+_153724847 2.66 ENST00000218104.6
ATP binding cassette subfamily D member 1
chr2_+_74530018 2.54 ENST00000437202.1
HtrA serine peptidase 2
chr3_+_54123452 2.49 ENST00000620722.4
ENST00000490478.5
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr1_+_25272527 2.47 ENST00000342055.9
ENST00000357542.8
ENST00000417538.6
ENST00000423810.6
ENST00000568195.5
Rh blood group D antigen
chr17_+_43025203 2.38 ENST00000587250.4
Rho family GTPase 2
chr2_-_181680490 2.37 ENST00000684145.1
ENST00000295108.4
ENST00000684079.1
ENST00000683430.1
ceramide kinase like
neuronal differentiation 1
chr22_+_44677077 2.35 ENST00000403581.5
proline rich 5
chr14_-_81533800 2.24 ENST00000555824.5
ENST00000557372.1
ENST00000336735.9
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
chr17_-_76027212 2.19 ENST00000586740.1
envoplakin
chr9_-_135499846 2.16 ENST00000429260.7
chromosome 9 open reading frame 116
chr16_+_29900474 2.15 ENST00000308748.10
aspartate beta-hydroxylase domain containing 1
chr4_+_183506082 2.08 ENST00000412117.1
inhibitor of growth family member 2
chr16_+_30664334 2.04 ENST00000287468.5
fibrosin
chr22_+_44677044 2.04 ENST00000006251.11
proline rich 5
chr9_-_137221323 2.03 ENST00000391553.2
ENST00000392827.2
ring finger protein 208
chr19_+_10452891 1.95 ENST00000344979.7
phosphodiesterase 4A
chr1_+_12063285 1.91 ENST00000263932.7
TNF receptor superfamily member 8
chr2_+_70900546 1.90 ENST00000234392.3
ventral anterior homeobox 2
chr16_+_66961242 1.82 ENST00000394037.5
ENST00000303334.9
carboxylesterase 3
chr10_-_118046922 1.82 ENST00000355624.8
RAB11 family interacting protein 2
chr17_-_64230727 1.81 ENST00000583097.5
ENST00000615733.4
testis expressed 2
chr5_+_134114673 1.74 ENST00000342854.10
ENST00000395029.5
transcription factor 7
chr19_-_44356664 1.64 ENST00000354340.9
ENST00000337401.8
ENST00000587909.1
zinc finger protein 112
chr17_-_28854972 1.57 ENST00000583953.6
family with sequence similarity 222 member B
chr10_-_48493641 1.54 ENST00000417247.6
Rho GTPase activating protein 22
chr11_-_4393650 1.53 ENST00000254436.8
tripartite motif containing 21
chrX_+_7219431 1.45 ENST00000674499.1
ENST00000217961.5
steroid sulfatase
chr3_-_197749688 1.41 ENST00000273582.9
rubicon autophagy regulator
chr2_+_73214233 1.40 ENST00000389501.9
ENST00000629411.2
SMYD family member 5
chr11_+_67483019 1.38 ENST00000279146.8
ENST00000528641.7
ENST00000682324.1
ENST00000684006.1
ENST00000683237.1
ENST00000684657.1
aryl hydrocarbon receptor interacting protein
chr21_+_46001300 1.37 ENST00000612273.2
ENST00000682634.1
collagen type VI alpha 1 chain
chr17_-_2711633 1.35 ENST00000435359.5
clustered mitochondria homolog
chr20_+_8789517 1.32 ENST00000437439.2
phospholipase C beta 1
chr5_-_33891941 1.29 ENST00000352040.7
ENST00000504830.6
ADAM metallopeptidase with thrombospondin type 1 motif 12
chr11_+_62613236 1.25 ENST00000278833.4
retinal outer segment membrane protein 1
chr1_-_23825402 1.20 ENST00000235958.4
ENST00000436439.6
ENST00000374490.8
3-hydroxy-3-methylglutaryl-CoA lyase
chr17_+_66302606 1.18 ENST00000413366.8
protein kinase C alpha
chr3_-_194398354 1.16 ENST00000401815.1
glycoprotein V platelet
chr20_-_3663399 1.13 ENST00000290417.7
ENST00000319242.8
GDNF family receptor alpha 4
chr1_+_26234157 1.09 ENST00000640292.2
ENST00000451429.8
ENST00000252992.8
centrosomal protein 85
chr7_-_78771265 1.08 ENST00000630991.2
ENST00000629359.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_-_84384871 1.07 ENST00000296591.10
EGF like repeats and discoidin domains 3
chr17_-_2711736 0.98 ENST00000651024.2
ENST00000576885.5
ENST00000574426.7
clustered mitochondria homolog
chr17_+_7630094 0.96 ENST00000441599.6
ENST00000380450.9
ENST00000416273.7
ENST00000575903.5
ENST00000571153.5
ENST00000575618.5
ENST00000576152.1
ENST00000576830.5
sex hormone binding globulin
chr17_-_74859863 0.95 ENST00000293190.10
glutamate ionotropic receptor NMDA type subunit 2C
chrX_-_107206426 0.88 ENST00000372466.8
ENST00000421752.1
nucleoporin 62 C-terminal like
chr19_-_42132465 0.83 ENST00000529067.5
ENST00000529952.5
ENST00000342301.8
ENST00000389341.9
POU class 2 homeobox 2
chr11_-_58578096 0.79 ENST00000528954.5
ENST00000528489.1
leupaxin
chr19_-_3062772 0.65 ENST00000586742.5
TLE family member 5, transcriptional modulator
chr5_+_32710630 0.58 ENST00000326958.5
natriuretic peptide receptor 3
chr17_-_63931354 0.57 ENST00000647774.1
novel protein
chr22_+_29307005 0.57 ENST00000406549.7
ENST00000610653.4
ENST00000621062.4
ENST00000611648.2
ENST00000618518.3
growth arrest specific 2 like 1
chr22_+_44676808 0.56 ENST00000624862.3
proline rich 5
chr3_-_49021045 0.52 ENST00000440857.5
DALR anticodon binding domain containing 3
chr1_-_16613481 0.48 ENST00000430580.6
ENST00000432949.5
NBPF member 1
chr10_+_62804710 0.48 ENST00000373783.3
2-aminoethanethiol dioxygenase
chrX_+_47561172 0.35 ENST00000377045.9
ENST00000377039.2
A-Raf proto-oncogene, serine/threonine kinase
chr3_-_48595267 0.29 ENST00000328333.12
ENST00000681320.1
collagen type VII alpha 1 chain
chr3_-_114199407 0.16 ENST00000460779.5
dopamine receptor D3
chr6_+_44158807 0.11 ENST00000532171.5
ENST00000398776.2
calpain 11
chr19_-_3062464 0.06 ENST00000327141.9
TLE family member 5, transcriptional modulator
chr11_-_89491131 0.06 ENST00000343727.9
ENST00000531342.5
ENST00000375979.7
NADPH oxidase 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.4 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
5.1 86.5 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
4.3 34.4 GO:0061709 reticulophagy(GO:0061709)
3.9 15.5 GO:0006562 proline catabolic process(GO:0006562)
3.7 18.5 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
3.3 35.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
3.0 9.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
2.8 11.3 GO:0090301 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
2.7 8.1 GO:0044565 dendritic cell proliferation(GO:0044565)
2.7 56.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
2.6 7.9 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
2.6 7.7 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
2.5 22.8 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
2.5 10.0 GO:0051866 general adaptation syndrome(GO:0051866)
2.4 9.8 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
2.4 12.2 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
2.4 14.2 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
2.2 8.7 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
2.2 8.7 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
2.2 6.5 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
2.0 7.8 GO:2000297 negative regulation of synapse maturation(GO:2000297)
1.9 5.8 GO:0070055 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054) mRNA endonucleolytic cleavage involved in unfolded protein response(GO:0070055)
1.9 5.8 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
1.8 14.7 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.7 13.7 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
1.6 4.9 GO:0045554 TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556)
1.4 8.2 GO:0016926 protein desumoylation(GO:0016926)
1.3 25.5 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
1.2 3.5 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
1.1 9.2 GO:0035524 proline transmembrane transport(GO:0035524)
1.0 4.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
1.0 5.9 GO:0048807 female genitalia morphogenesis(GO:0048807)
1.0 2.9 GO:0061760 antifungal innate immune response(GO:0061760)
0.9 3.8 GO:0048850 hypophysis morphogenesis(GO:0048850) diencephalon morphogenesis(GO:0048852)
0.9 2.8 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.9 11.2 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.8 7.4 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.8 7.4 GO:1902037 positive regulation of hematopoietic stem cell proliferation(GO:1902035) negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.8 8.0 GO:0071321 cellular response to cGMP(GO:0071321)
0.8 2.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.8 19.5 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.7 4.1 GO:0035723 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
0.7 2.7 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.6 5.8 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.6 2.5 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.6 20.8 GO:0015695 organic cation transport(GO:0015695)
0.6 12.6 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.5 7.6 GO:0036158 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.5 1.4 GO:1901097 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of autophagosome maturation(GO:1901097)
0.4 5.7 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.4 15.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.4 13.0 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.4 4.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.4 4.3 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.4 1.5 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.4 4.9 GO:0038203 TORC2 signaling(GO:0038203)
0.4 3.3 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.3 1.7 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.3 12.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.3 8.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 2.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.3 7.6 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.3 5.7 GO:0044458 motile cilium assembly(GO:0044458)
0.3 2.1 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 1.2 GO:2000705 desmosome assembly(GO:0002159) dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.3 11.9 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.3 1.3 GO:1902202 proteoglycan catabolic process(GO:0030167) regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.2 4.4 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.2 16.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 2.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 6.0 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 4.2 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.2 3.3 GO:0051014 actin filament severing(GO:0051014)
0.2 3.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.9 GO:0033058 directional locomotion(GO:0033058)
0.2 5.0 GO:0033599 regulation of mammary gland epithelial cell proliferation(GO:0033599)
0.1 1.1 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.1 1.1 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 4.7 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 11.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 3.6 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 2.0 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 3.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 1.2 GO:0046951 leucine catabolic process(GO:0006552) ketone body biosynthetic process(GO:0046951)
0.1 2.2 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.1 1.9 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.1 0.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 7.4 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 9.0 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.1 0.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 0.5 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 1.3 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.1 1.1 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 7.0 GO:0007286 spermatid development(GO:0007286)
0.1 0.2 GO:0035483 gastric motility(GO:0035482) gastric emptying(GO:0035483)
0.1 5.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 4.0 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 8.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 1.5 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.6 GO:0030157 pancreatic juice secretion(GO:0030157)
0.0 6.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.8 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.0 5.8 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.0 9.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 4.8 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 8.8 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 5.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 4.3 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 3.2 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.0 0.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 4.0 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 2.8 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 2.4 GO:0061337 cardiac conduction(GO:0061337)
0.0 0.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.5 GO:1990622 CHOP-ATF3 complex(GO:1990622)
4.3 12.8 GO:0031251 PAN complex(GO:0031251)
3.4 13.7 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
3.3 13.0 GO:1990879 CST complex(GO:1990879)
3.1 15.6 GO:0097513 myosin II filament(GO:0097513)
2.1 10.3 GO:0036398 TCR signalosome(GO:0036398)
1.9 5.8 GO:1990597 AIP1-IRE1 complex(GO:1990597)
1.8 25.5 GO:0035859 Seh1-associated complex(GO:0035859)
1.4 10.0 GO:0032280 symmetric synapse(GO:0032280)
1.3 7.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.0 19.2 GO:0010369 chromocenter(GO:0010369)
0.9 11.2 GO:0097427 microtubule bundle(GO:0097427)
0.8 14.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.7 8.7 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.7 4.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.6 5.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.5 34.4 GO:0005801 cis-Golgi network(GO:0005801)
0.5 12.4 GO:0097440 apical dendrite(GO:0097440)
0.5 12.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.4 2.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.4 25.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.3 7.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 72.9 GO:0030426 growth cone(GO:0030426)
0.3 8.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 4.9 GO:0031932 TORC2 complex(GO:0031932)
0.2 13.9 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 3.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 3.3 GO:0032059 bleb(GO:0032059)
0.2 3.5 GO:1990909 Wnt signalosome(GO:1990909)
0.2 14.7 GO:0001772 immunological synapse(GO:0001772)
0.2 57.5 GO:0043209 myelin sheath(GO:0043209)
0.2 7.6 GO:0034451 centriolar satellite(GO:0034451)
0.2 7.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 7.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 2.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 4.0 GO:0051233 spindle midzone(GO:0051233)
0.2 4.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 21.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 2.8 GO:0042101 T cell receptor complex(GO:0042101)
0.1 8.2 GO:0015030 Cajal body(GO:0015030)
0.1 8.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 9.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 2.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.1 GO:0000242 pericentriolar material(GO:0000242)
0.1 24.9 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 2.4 GO:0002080 acrosomal membrane(GO:0002080)
0.1 5.8 GO:0005901 caveola(GO:0005901)
0.1 2.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 1.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 8.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 1.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 9.4 GO:0008021 synaptic vesicle(GO:0008021)
0.1 0.9 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 4.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 17.5 GO:0005874 microtubule(GO:0005874)
0.0 3.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 5.0 GO:0001650 fibrillar center(GO:0001650)
0.0 4.0 GO:0030018 Z disc(GO:0030018)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 5.8 GO:0045177 apical part of cell(GO:0045177)
0.0 47.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 56.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
2.3 13.9 GO:0070728 leucine binding(GO:0070728)
2.0 25.5 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
1.9 11.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.8 9.2 GO:0005298 proline:sodium symporter activity(GO:0005298)
1.6 8.0 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
1.4 10.0 GO:0001515 opioid peptide activity(GO:0001515)
1.4 8.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
1.2 18.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
1.2 35.3 GO:0071949 FAD binding(GO:0071949)
1.1 19.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
1.0 10.5 GO:0033691 sialic acid binding(GO:0033691)
0.7 22.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 12.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.6 3.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.6 7.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.6 20.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.6 11.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.5 3.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.5 12.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.5 12.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 8.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.5 13.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.4 11.9 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 1.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 2.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.4 2.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 5.9 GO:0016918 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.4 8.0 GO:0030275 LRR domain binding(GO:0030275)
0.4 1.5 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.4 5.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.3 4.0 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 4.9 GO:0048406 nerve growth factor binding(GO:0048406)
0.3 3.9 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.3 3.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 1.2 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.3 16.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.3 4.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.3 24.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 5.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.3 5.8 GO:0045499 chemorepellent activity(GO:0045499)
0.3 4.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 13.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.2 2.4 GO:0046625 sphingolipid binding(GO:0046625)
0.2 14.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 1.9 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.2 17.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 1.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 8.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 7.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 3.3 GO:0005522 profilin binding(GO:0005522)
0.2 7.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.2 5.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 1.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.2 3.5 GO:0048018 receptor agonist activity(GO:0048018)
0.1 1.0 GO:0005497 androgen binding(GO:0005497)
0.1 1.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 7.6 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 12.2 GO:0002039 p53 binding(GO:0002039)
0.1 7.2 GO:0015485 cholesterol binding(GO:0015485)
0.1 7.8 GO:0070888 E-box binding(GO:0070888)
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 5.7 GO:0051018 protein kinase A binding(GO:0051018)
0.1 2.0 GO:0030552 cAMP binding(GO:0030552)
0.1 5.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 14.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.8 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 17.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 23.4 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 6.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 5.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 2.6 GO:0051213 dioxygenase activity(GO:0051213)
0.0 3.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 2.5 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.4 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 2.4 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 4.0 GO:0008047 enzyme activator activity(GO:0008047)
0.0 1.4 GO:0008168 methyltransferase activity(GO:0008168)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 15.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.7 105.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.6 25.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 13.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.3 8.4 PID ARF 3PATHWAY Arf1 pathway
0.3 22.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.3 13.1 PID RAS PATHWAY Regulation of Ras family activation
0.3 8.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.3 12.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.3 9.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 17.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 12.2 PID TNF PATHWAY TNF receptor signaling pathway
0.2 9.0 PID LKB1 PATHWAY LKB1 signaling events
0.2 11.9 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.2 4.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 4.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 3.2 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 9.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 10.0 PID AP1 PATHWAY AP-1 transcription factor network
0.1 3.3 PID ALK1 PATHWAY ALK1 signaling events
0.1 5.4 PID BCR 5PATHWAY BCR signaling pathway
0.1 3.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 9.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 1.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 4.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.6 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 18.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.7 47.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.6 13.7 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.5 9.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.5 2.8 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.4 10.3 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.4 15.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 7.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 9.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 15.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 11.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 7.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 10.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 2.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 4.1 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 9.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 7.9 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.1 3.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 2.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 6.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 8.0 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 13.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 5.8 REACTOME UNFOLDED PROTEIN RESPONSE Genes involved in Unfolded Protein Response
0.1 2.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 2.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 3.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation