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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR4A1

Z-value: 5.78

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Transcription factors associated with NR4A1

Gene Symbol Gene ID Gene Info
NR4A1
ENSG00000123358.20 NR4A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR4A1hg38_v1_chr12_+_52051402_520514590.386.4e-09Click!

Activity profile of NR4A1 motif

Sorted Z-values of NR4A1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_16605939 47.87 ENST00000541295.5
ENST00000535535.5
LMO3
LIM domain only 3
chr12_-_16606102 47.77 ENST00000537304.6
LMO3
LIM domain only 3
chr8_-_119673368 26.19 ENST00000427067.6
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr12_-_16606795 25.95 ENST00000447609.5
LMO3
LIM domain only 3
chr11_-_111923722 25.55 ENST00000527950.5
CRYAB
crystallin alpha B
chr3_-_139044892 22.06 ENST00000413199.1
PRR23C
proline rich 23C
chr7_-_37448845 16.39 ENST00000310758.9
ELMO1
engulfment and cell motility 1
chr6_-_152637351 15.15 ENST00000367255.10
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr19_+_54415427 14.05 ENST00000301194.8
ENST00000376530.8
ENST00000445095.5
ENST00000376531.3
TTYH1
tweety family member 1
chr13_-_32538683 12.50 ENST00000674456.1
ENST00000504114.5
N4BP2L2
NEDD4 binding protein 2 like 2
chr7_-_38631356 12.35 ENST00000356264.7
ENST00000325590.9
AMPH
amphiphysin
chr17_-_31297231 11.44 ENST00000247271.5
OMG
oligodendrocyte myelin glycoprotein
chr6_+_69232406 10.55 ENST00000238918.12
ADGRB3
adhesion G protein-coupled receptor B3
chr10_-_73874461 9.81 ENST00000305762.11
CAMK2G
calcium/calmodulin dependent protein kinase II gamma
chr3_-_115147277 9.80 ENST00000675478.1
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_115147237 9.37 ENST00000357258.8
ZBTB20
zinc finger and BTB domain containing 20
chr15_+_43692886 9.03 ENST00000434505.5
ENST00000411750.5
CKMT1A
creatine kinase, mitochondrial 1A
chr13_-_32538819 8.41 ENST00000674452.1
ENST00000674422.1
ENST00000674349.1
ENST00000674465.1
ENST00000674327.1
ENST00000505213.5
ENST00000357505.10
ENST00000399396.7
N4BP2L2
NEDD4 binding protein 2 like 2
chr1_+_156619406 8.33 ENST00000255039.6
ENST00000456112.1
HAPLN2
hyaluronan and proteoglycan link protein 2
chr6_-_152168291 8.17 ENST00000354674.5
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr6_-_152168349 8.10 ENST00000539504.5
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr6_+_30626842 7.85 ENST00000318999.11
ENST00000376485.8
ENST00000330083.6
ENST00000319027.9
ENST00000376483.8
ENST00000329992.12
ATAT1
alpha tubulin acetyltransferase 1
chr4_+_176065827 7.15 ENST00000508596.6
WDR17
WD repeat domain 17
chr3_+_184337591 7.07 ENST00000383847.7
FAM131A
family with sequence similarity 131 member A
chr12_+_109139397 6.74 ENST00000377854.9
ENST00000377848.7
ACACB
acetyl-CoA carboxylase beta
chr1_+_236686454 6.32 ENST00000542672.6
ENST00000366578.6
ENST00000682015.1
ENST00000651275.1
ACTN2
actinin alpha 2
chr1_+_160205374 6.14 ENST00000368077.5
ENST00000360472.9
PEA15
proliferation and apoptosis adaptor protein 15
chr10_-_73591330 6.04 ENST00000451492.5
ENST00000681793.1
ENST00000680396.1
ENST00000413442.5
USP54
ubiquitin specific peptidase 54
chr2_+_233307806 5.94 ENST00000447536.5
ENST00000409110.6
SAG
S-antigen visual arrestin
chr1_+_50103903 5.78 ENST00000371827.5
ELAVL4
ELAV like RNA binding protein 4
chr13_-_32538732 5.67 ENST00000674437.1
N4BP2L2
NEDD4 binding protein 2 like 2
chr1_+_160205411 5.67 ENST00000368076.1
PEA15
proliferation and apoptosis adaptor protein 15
chr13_-_32538762 5.46 ENST00000267068.5
ENST00000674428.1
ENST00000674297.1
ENST00000674180.1
ENST00000674421.1
ENST00000674484.1
ENST00000674377.1
N4BP2L2
NEDD4 binding protein 2 like 2
chr12_-_95073490 5.24 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2 group C member 1
chr4_-_88823165 5.21 ENST00000508369.5
FAM13A
family with sequence similarity 13 member A
chr1_+_69567906 5.15 ENST00000651989.2
LRRC7
leucine rich repeat containing 7
chr17_-_7219813 5.06 ENST00000399510.8
ENST00000648172.8
DLG4
discs large MAGUK scaffold protein 4
chr1_+_13749408 5.05 ENST00000343137.8
ENST00000503842.5
ENST00000407521.7
ENST00000505823.5
PRDM2
PR/SET domain 2
chr12_+_6535278 4.93 ENST00000396858.5
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr19_-_40750302 4.66 ENST00000598485.6
ENST00000378313.7
ENST00000470681.5
C19orf54
chromosome 19 open reading frame 54
chr7_-_102616692 4.63 ENST00000521076.5
ENST00000462172.5
ENST00000522801.5
ENST00000262940.12
ENST00000449970.6
RASA4
RAS p21 protein activator 4
chr4_-_86358487 4.57 ENST00000641066.1
ENST00000512689.6
ENST00000641803.1
ENST00000640970.1
ENST00000641983.1
MAPK10
mitogen-activated protein kinase 10
chr19_-_5622768 4.53 ENST00000252542.9
SAFB2
scaffold attachment factor B2
chr12_+_21526287 4.44 ENST00000256969.7
SPX
spexin hormone
chr22_+_24495242 4.42 ENST00000382760.2
ENST00000326010.10
UPB1
beta-ureidopropionase 1
chr19_+_49210734 4.31 ENST00000597316.1
TRPM4
transient receptor potential cation channel subfamily M member 4
chr18_-_55302613 4.19 ENST00000561831.7
TCF4
transcription factor 4
chr16_+_55655960 4.15 ENST00000568943.6
SLC6A2
solute carrier family 6 member 2
chr1_+_192809031 4.10 ENST00000235382.7
RGS2
regulator of G protein signaling 2
chr4_-_88823214 4.08 ENST00000513837.5
ENST00000503556.5
FAM13A
family with sequence similarity 13 member A
chr10_-_102056116 4.08 ENST00000370033.9
ENST00000311122.5
ARMH3
armadillo like helical domain containing 3
chr1_+_174799895 4.01 ENST00000489615.5
RABGAP1L
RAB GTPase activating protein 1 like
chr10_+_12068945 3.88 ENST00000263035.9
DHTKD1
dehydrogenase E1 and transketolase domain containing 1
chr10_+_80413817 3.83 ENST00000372187.9
PRXL2A
peroxiredoxin like 2A
chr3_+_14947680 3.72 ENST00000435454.5
ENST00000323373.10
NR2C2
nuclear receptor subfamily 2 group C member 2
chr7_-_126533850 3.65 ENST00000444921.3
GRM8
glutamate metabotropic receptor 8
chr20_+_3071618 3.58 ENST00000217386.2
OXT
oxytocin/neurophysin I prepropeptide
chr1_+_176463164 3.56 ENST00000367661.7
ENST00000367662.5
PAPPA2
pappalysin 2
chr14_+_69484722 3.53 ENST00000322564.9
PLEKHD1
pleckstrin homology and coiled-coil domain containing D1
chr12_+_18242955 3.30 ENST00000676171.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr16_+_81238682 3.28 ENST00000258168.7
ENST00000564552.1
BCO1
beta-carotene oxygenase 1
chr3_-_44477639 3.27 ENST00000396077.8
ZNF445
zinc finger protein 445
chr2_-_47176453 3.25 ENST00000484408.5
ENST00000489742.1
ENST00000272298.12
ENST00000656538.1
ENST00000409563.5
ENST00000456319.6
ENST00000628793.2
CALM2
calmodulin 2
chr10_-_17129786 3.18 ENST00000377833.10
CUBN
cubilin
chr2_-_25252072 2.89 ENST00000683760.1
DNMT3A
DNA methyltransferase 3 alpha
chr17_+_4951758 2.80 ENST00000518175.1
ENO3
enolase 3
chr15_-_40828699 2.74 ENST00000299174.10
ENST00000427255.2
PPP1R14D
protein phosphatase 1 regulatory inhibitor subunit 14D
chr3_+_101724602 2.73 ENST00000341893.8
CEP97
centrosomal protein 97
chr17_+_4951080 2.64 ENST00000521811.5
ENST00000323997.10
ENST00000522249.5
ENST00000519584.5
ENST00000519602.6
ENO3
enolase 3
chr14_-_95157270 2.64 ENST00000674628.1
ENST00000529720.1
ENST00000393063.6
ENST00000532939.3
DICER1
dicer 1, ribonuclease III
chr6_-_33803980 2.57 ENST00000507738.1
ENST00000266003.9
ENST00000430124.7
MLN
motilin
chr7_-_6009019 2.53 ENST00000382321.5
ENST00000265849.12
PMS2
PMS1 homolog 2, mismatch repair system component
chr3_-_48898813 2.43 ENST00000319017.5
ENST00000430379.5
SLC25A20
solute carrier family 25 member 20
chr15_-_42491105 2.39 ENST00000565380.5
ENST00000564754.7
ZNF106
zinc finger protein 106
chr20_-_45857196 2.39 ENST00000457981.5
ENST00000426915.1
ENST00000217455.9
ACOT8
acyl-CoA thioesterase 8
chr3_-_50503597 2.23 ENST00000266039.7
ENST00000424201.7
CACNA2D2
calcium voltage-gated channel auxiliary subunit alpha2delta 2
chr5_-_74866779 2.11 ENST00000510496.5
FAM169A
family with sequence similarity 169 member A
chr4_+_70242583 2.08 ENST00000304954.3
CSN3
casein kappa
chr2_+_161160299 2.04 ENST00000440506.5
ENST00000429217.5
ENST00000406287.5
ENST00000402568.5
TANK
TRAF family member associated NFKB activator
chr6_+_63636481 1.82 ENST00000509330.5
PHF3
PHD finger protein 3
chr16_+_31355165 1.72 ENST00000562918.5
ENST00000268296.9
ITGAX
integrin subunit alpha X
chr20_+_58891981 1.72 ENST00000488652.6
ENST00000476935.6
ENST00000492907.6
ENST00000603546.2
GNAS
GNAS complex locus
chr16_+_31355215 1.70 ENST00000562522.2
ITGAX
integrin subunit alpha X
chr2_+_161160420 1.68 ENST00000392749.7
ENST00000405852.5
TANK
TRAF family member associated NFKB activator
chr9_-_72953047 1.66 ENST00000297785.8
ENST00000376939.5
ALDH1A1
aldehyde dehydrogenase 1 family member A1
chr6_+_118548289 1.65 ENST00000357525.6
PLN
phospholamban
chr7_-_6009072 1.53 ENST00000642456.1
ENST00000642292.1
ENST00000441476.6
PMS2
PMS1 homolog 2, mismatch repair system component
chr3_+_51707059 1.51 ENST00000395052.8
GRM2
glutamate metabotropic receptor 2
chr1_-_161132659 1.51 ENST00000368006.8
ENST00000490843.6
ENST00000545495.5
DEDD
death effector domain containing
chr7_+_12570712 1.34 ENST00000417018.1
ENST00000297029.10
SCIN
scinderin
chr3_+_29280945 1.21 ENST00000434693.6
RBMS3
RNA binding motif single stranded interacting protein 3
chr3_+_14947568 1.19 ENST00000413118.5
ENST00000425241.5
NR2C2
nuclear receptor subfamily 2 group C member 2
chr1_-_111200633 1.18 ENST00000357640.9
DENND2D
DENN domain containing 2D
chrX_+_2828808 1.17 ENST00000381163.7
GYG2
glycogenin 2
chr20_+_38962299 1.17 ENST00000373325.6
ENST00000373323.8
ENST00000252011.8
ENST00000615559.1
DHX35
ENSG00000277581.1
DEAH-box helicase 35
novel transcript, sense intronic to DHX35
chr18_+_46174014 1.16 ENST00000619301.4
ENST00000615052.5
C18orf25
chromosome 18 open reading frame 25
chr4_-_88823306 1.11 ENST00000395002.6
FAM13A
family with sequence similarity 13 member A
chr7_+_121328991 1.10 ENST00000222462.3
WNT16
Wnt family member 16
chr14_+_35122537 1.05 ENST00000604948.5
ENST00000321130.14
ENST00000534898.9
ENST00000605201.1
ENST00000250377.11
PRORP
protein only RNase P catalytic subunit
chr22_-_50578417 1.03 ENST00000312108.12
ENST00000395650.6
CPT1B
carnitine palmitoyltransferase 1B
chrX_+_2828921 1.00 ENST00000398806.8
GYG2
glycogenin 2
chr8_+_98944403 0.94 ENST00000457907.3
ENST00000523368.5
ENST00000297565.8
ENST00000435298.6
OSR2
odd-skipped related transciption factor 2
chr19_-_4066892 0.91 ENST00000322357.9
ZBTB7A
zinc finger and BTB domain containing 7A
chr15_-_56245074 0.90 ENST00000674082.1
RFX7
regulatory factor X7
chr3_+_113747022 0.84 ENST00000273398.8
ENST00000496747.5
ENST00000475322.1
ATP6V1A
ATPase H+ transporting V1 subunit A
chr11_+_3855629 0.84 ENST00000526596.2
ENST00000300737.8
ENST00000616714.4
STIM1
stromal interaction molecule 1
chr1_+_117001744 0.74 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101
CD101 molecule
chr14_-_95157890 0.71 ENST00000526495.6
DICER1
dicer 1, ribonuclease III
chr18_-_63319729 0.68 ENST00000333681.5
BCL2
BCL2 apoptosis regulator
chr17_-_68291116 0.56 ENST00000327268.8
ENST00000580666.6
SLC16A6
solute carrier family 16 member 6
chr10_+_99782628 0.51 ENST00000648689.1
ENST00000647814.1
ABCC2
ATP binding cassette subfamily C member 2
chr17_-_2266131 0.46 ENST00000570606.5
ENST00000354901.8
SMG6
SMG6 nonsense mediated mRNA decay factor
chr6_+_31927486 0.44 ENST00000442278.6
C2
complement C2
chr19_-_11529116 0.44 ENST00000592312.5
ENST00000590480.1
ENST00000585318.5
ENST00000270517.12
ENST00000252440.11
ENST00000417981.6
ECSIT
ECSIT signaling integrator
chr14_-_95157482 0.36 ENST00000343455.8
DICER1
dicer 1, ribonuclease III
chr1_-_161132577 0.33 ENST00000464113.1
DEDD
death effector domain containing
chr12_+_93569814 0.21 ENST00000340600.6
SOCS2
suppressor of cytokine signaling 2
chr4_+_99574812 0.11 ENST00000422897.6
ENST00000265517.10
MTTP
microsomal triglyceride transfer protein
chr2_+_176157293 0.08 ENST00000683222.1
HOXD3
homeobox D3
chr18_+_58196736 0.03 ENST00000675221.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr6_+_31927703 0.03 ENST00000418949.6
ENST00000299367.10
ENST00000383177.7
ENST00000477310.1
C2
ENSG00000244255.5
complement C2
novel complement component 2 (C2) and complement factor B (CFB) protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.4 121.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
3.6 32.0 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
3.1 31.4 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
2.8 8.3 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
2.6 10.6 GO:0099558 maintenance of synapse structure(GO:0099558)
1.7 26.2 GO:2000394 phosphatidylcholine catabolic process(GO:0034638) positive regulation of lamellipodium morphogenesis(GO:2000394)
1.6 6.3 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
1.5 25.6 GO:0007021 tubulin complex assembly(GO:0007021)
1.5 4.4 GO:0019482 beta-alanine metabolic process(GO:0019482)
1.4 4.3 GO:1903781 positive regulation of cardiac conduction(GO:1903781)
1.3 6.7 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
1.2 3.7 GO:0036404 conversion of ds siRNA to ss siRNA involved in RNA interference(GO:0033168) conversion of ds siRNA to ss siRNA(GO:0036404)
1.2 4.9 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.2 3.6 GO:0002125 maternal aggressive behavior(GO:0002125)
0.7 4.4 GO:1904306 regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.7 7.8 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.6 11.8 GO:0046325 negative regulation of glucose import(GO:0046325)
0.6 3.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.6 11.5 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.6 9.0 GO:0006600 creatine metabolic process(GO:0006600)
0.6 4.1 GO:0071877 regulation of adrenergic receptor signaling pathway(GO:0071877)
0.6 2.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.5 5.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.5 14.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.5 2.9 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.4 5.1 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.4 16.4 GO:0016601 Rac protein signal transduction(GO:0016601)
0.4 19.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 3.2 GO:0015889 cobalamin transport(GO:0015889)
0.3 4.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 5.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.3 1.7 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.3 1.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.3 4.1 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 2.7 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.2 3.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.2 5.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 0.8 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)
0.2 3.5 GO:0006853 carnitine shuttle(GO:0006853)
0.2 1.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.2 4.2 GO:0090493 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.2 2.4 GO:0016559 peroxisome fission(GO:0016559)
0.2 0.5 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.2 5.9 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.2 0.7 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 0.9 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.1 4.5 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.1 11.4 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.1 5.4 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.7 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 3.9 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 3.3 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 0.5 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.1 4.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 2.2 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 4.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.5 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 2.3 GO:0007595 lactation(GO:0007595)
0.0 0.8 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 9.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 3.6 GO:0060349 bone morphogenesis(GO:0060349)
0.0 3.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 6.0 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 2.4 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 5.8 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 12.4 GO:0007268 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.0 0.7 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 31.4 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.8 14.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.6 25.6 GO:0097512 cardiac myofibril(GO:0097512)
1.2 3.7 GO:0033167 ARC complex(GO:0033167)
1.2 16.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.7 10.6 GO:0043083 synaptic cleft(GO:0043083)
0.7 5.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 7.8 GO:0097427 microtubule bundle(GO:0097427)
0.6 3.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.5 4.9 GO:0097452 GAIT complex(GO:0097452)
0.5 3.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.4 5.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.4 4.1 GO:0032389 MutLalpha complex(GO:0032389)
0.3 4.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 32.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 4.4 GO:0031045 dense core granule(GO:0031045)
0.2 6.3 GO:0031143 pseudopodium(GO:0031143)
0.2 2.9 GO:0001741 XY body(GO:0001741)
0.2 10.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 0.5 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 12.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 4.3 GO:0034706 sodium channel complex(GO:0034706)
0.1 3.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 5.9 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 11.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 11.8 GO:0005875 microtubule associated complex(GO:0005875)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 3.6 GO:0043195 terminal bouton(GO:0043195)
0.0 5.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.4 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 5.2 GO:0016605 PML body(GO:0016605)
0.0 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 8.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.3 GO:0002102 podosome(GO:0002102)
0.0 8.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.2 GO:0000922 spindle pole(GO:0000922)
0.0 5.1 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 2.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 25.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 8.7 GO:0043005 neuron projection(GO:0043005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 26.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
3.5 14.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.6 4.9 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
1.5 5.9 GO:0002046 opsin binding(GO:0002046)
1.3 6.7 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.3 7.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.3 6.3 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
1.1 9.0 GO:0004111 creatine kinase activity(GO:0004111)
1.0 31.4 GO:0005521 lamin binding(GO:0005521)
1.0 4.2 GO:0005334 norepinephrine:sodium symporter activity(GO:0005334)
0.9 25.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.8 2.4 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.8 2.4 GO:0052815 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
0.8 3.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.8 32.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.8 9.8 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.7 3.7 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.7 2.2 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.7 5.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 5.1 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.6 3.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.5 1.5 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.5 2.9 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.4 1.6 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.4 4.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.4 4.6 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 3.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.3 1.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2 3.2 GO:0031419 cobalamin binding(GO:0031419)
0.2 8.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.0 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.2 8.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 4.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 5.8 GO:0017091 AU-rich element binding(GO:0017091)
0.1 4.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 3.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 18.3 GO:0017124 SH3 domain binding(GO:0017124)
0.1 4.3 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 3.6 GO:0008066 glutamate receptor activity(GO:0008066)
0.1 16.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 29.6 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.7 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 2.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.7 GO:0051434 BH3 domain binding(GO:0051434)
0.1 6.0 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 1.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 4.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 4.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 2.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.5 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.8 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.0 3.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 8.5 GO:0005543 phospholipid binding(GO:0005543)
0.0 1.2 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 2.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 68.3 GO:0046872 metal ion binding(GO:0046872)
0.0 1.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 9.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 5.9 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.2 9.5 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.2 8.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 12.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.2 5.1 ST GA12 PATHWAY G alpha 12 Pathway
0.1 4.6 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 11.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.1 13.7 PID P73PATHWAY p73 transcription factor network
0.1 3.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 3.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 3.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 4.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 3.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 31.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 16.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 10.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.3 4.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 9.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 5.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 10.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 4.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 1.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 3.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 2.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 3.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 3.7 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 2.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 11.4 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 3.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.8 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 10.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 4.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 10.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.7 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 9.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.5 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.5 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport