Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NRF1
Z-value: 14.24
Motif logo
Transcription factors associated with NRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NRF1
|
ENSG00000106459.15 | NRF1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg38_v1_chr7_+_129611680_129611760 | -0.37 | 1.5e-08 | Click! |
Activity profile of NRF1 motif
Sorted Z-values of NRF1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 59.8 | 239.2 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 44.9 | 134.8 | GO:0032954 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 41.0 | 123.0 | GO:0060623 | regulation of chromosome condensation(GO:0060623) |
| 40.1 | 120.2 | GO:1904430 | negative regulation of t-circle formation(GO:1904430) |
| 38.8 | 310.5 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 35.3 | 141.2 | GO:0043335 | protein unfolding(GO:0043335) |
| 34.0 | 203.7 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 32.4 | 97.3 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 30.9 | 185.6 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 30.7 | 92.2 | GO:1903722 | regulation of centriole elongation(GO:1903722) |
| 29.0 | 116.1 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 28.3 | 141.6 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 27.6 | 82.7 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 25.6 | 76.8 | GO:2000234 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 24.8 | 99.1 | GO:0046833 | positive regulation of RNA export from nucleus(GO:0046833) |
| 23.2 | 69.6 | GO:0007057 | spindle assembly involved in female meiosis I(GO:0007057) |
| 22.9 | 91.8 | GO:0051311 | meiotic metaphase I plate congression(GO:0043060) negative regulation of mitotic recombination(GO:0045950) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311) |
| 22.3 | 89.1 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 21.6 | 64.7 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
| 21.4 | 85.7 | GO:0010286 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 21.1 | 190.1 | GO:0060699 | regulation of endoribonuclease activity(GO:0060699) |
| 20.8 | 62.3 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 20.7 | 82.7 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 20.5 | 123.3 | GO:0015853 | adenine transport(GO:0015853) |
| 20.2 | 121.4 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 19.9 | 119.6 | GO:1903333 | negative regulation of protein folding(GO:1903333) |
| 19.6 | 176.3 | GO:0007070 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 18.4 | 18.4 | GO:1903895 | negative regulation of IRE1-mediated unfolded protein response(GO:1903895) |
| 18.0 | 71.9 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 17.7 | 53.2 | GO:0006272 | leading strand elongation(GO:0006272) |
| 17.0 | 238.5 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 17.0 | 51.0 | GO:0034476 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) |
| 16.9 | 67.6 | GO:0045917 | positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) |
| 16.9 | 50.6 | GO:0006781 | succinyl-CoA pathway(GO:0006781) |
| 16.8 | 16.8 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
| 16.8 | 67.0 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 16.3 | 49.0 | GO:0044034 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) |
| 16.3 | 97.7 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 16.2 | 64.9 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 16.1 | 48.3 | GO:1904732 | regulation of electron carrier activity(GO:1904732) |
| 16.0 | 64.0 | GO:0044210 | 'de novo' CTP biosynthetic process(GO:0044210) |
| 15.9 | 142.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 15.8 | 47.3 | GO:0002368 | B cell cytokine production(GO:0002368) |
| 15.7 | 47.2 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149) |
| 15.7 | 31.4 | GO:0071046 | polyadenylation-dependent ncRNA catabolic process(GO:0043634) nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046) |
| 15.3 | 15.3 | GO:1903033 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) positive regulation of microtubule binding(GO:1904528) |
| 15.2 | 91.2 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 14.9 | 89.6 | GO:0006050 | mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051) |
| 14.8 | 59.1 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 14.8 | 147.6 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 14.5 | 72.7 | GO:0006529 | asparagine biosynthetic process(GO:0006529) |
| 14.2 | 57.0 | GO:0000912 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 14.1 | 84.3 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 14.0 | 28.0 | GO:0090069 | regulation of ribosome biogenesis(GO:0090069) |
| 14.0 | 153.5 | GO:0090261 | positive regulation of inclusion body assembly(GO:0090261) |
| 13.7 | 123.7 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 13.7 | 68.5 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 13.7 | 137.0 | GO:1901673 | regulation of mitotic spindle assembly(GO:1901673) |
| 13.6 | 40.9 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
| 13.6 | 68.1 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 13.5 | 80.9 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 13.4 | 40.2 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 13.3 | 53.1 | GO:2000435 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 12.8 | 38.4 | GO:0006311 | meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520) |
| 12.8 | 102.0 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 12.7 | 38.2 | GO:1901254 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 12.7 | 38.1 | GO:1902661 | positive regulation of glucose mediated signaling pathway(GO:1902661) |
| 12.7 | 164.5 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 12.2 | 36.7 | GO:1903973 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) regulation of positive thymic T cell selection(GO:1902232) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
| 12.2 | 73.1 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 12.1 | 36.4 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 11.9 | 11.9 | GO:1903181 | regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) |
| 11.9 | 83.2 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 11.9 | 71.2 | GO:0007008 | outer mitochondrial membrane organization(GO:0007008) |
| 11.9 | 711.6 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 11.8 | 35.4 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 11.8 | 105.8 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 11.7 | 152.0 | GO:0021769 | orbitofrontal cortex development(GO:0021769) |
| 11.7 | 46.7 | GO:1905244 | regulation of modification of synaptic structure(GO:1905244) |
| 11.6 | 161.9 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 11.5 | 46.1 | GO:0002188 | translation reinitiation(GO:0002188) |
| 11.5 | 149.1 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 11.4 | 79.8 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 11.4 | 56.8 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 11.3 | 158.5 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 11.3 | 33.9 | GO:0043461 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
| 11.3 | 45.2 | GO:1903758 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 11.2 | 33.6 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 11.1 | 55.7 | GO:0040031 | snRNA modification(GO:0040031) |
| 10.9 | 65.5 | GO:0036093 | male germ cell proliferation(GO:0002176) germ cell proliferation(GO:0036093) |
| 10.8 | 32.5 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 10.8 | 119.1 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 10.6 | 42.4 | GO:0009256 | 10-formyltetrahydrofolate metabolic process(GO:0009256) |
| 10.5 | 31.5 | GO:0036510 | trimming of terminal mannose on C branch(GO:0036510) |
| 10.4 | 31.3 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 10.4 | 62.4 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 10.4 | 31.1 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 10.2 | 51.1 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 10.2 | 40.9 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 10.2 | 204.1 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 10.0 | 30.1 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 10.0 | 30.1 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) |
| 9.6 | 57.9 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 9.6 | 28.7 | GO:1903719 | regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) |
| 9.5 | 66.4 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 9.4 | 46.9 | GO:1902896 | terminal web assembly(GO:1902896) |
| 9.3 | 27.9 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 9.3 | 55.7 | GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973) |
| 9.3 | 55.6 | GO:0071475 | cellular hyperosmotic salinity response(GO:0071475) |
| 9.2 | 18.4 | GO:0060382 | regulation of DNA strand elongation(GO:0060382) |
| 9.0 | 45.2 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 9.0 | 107.8 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 9.0 | 26.9 | GO:0043311 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 8.9 | 26.8 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
| 8.9 | 169.3 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 8.9 | 142.1 | GO:0000212 | meiotic spindle organization(GO:0000212) |
| 8.8 | 61.8 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 8.8 | 26.4 | GO:2000298 | regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 8.8 | 44.0 | GO:0044209 | AMP salvage(GO:0044209) |
| 8.7 | 8.7 | GO:1901628 | positive regulation of postsynaptic membrane organization(GO:1901628) |
| 8.6 | 103.3 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 8.6 | 51.5 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 8.6 | 17.1 | GO:0061739 | protein lipidation involved in autophagosome assembly(GO:0061739) |
| 8.5 | 17.0 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
| 8.4 | 8.4 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 8.4 | 41.9 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 8.3 | 75.1 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 8.3 | 16.6 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 8.1 | 40.5 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 8.1 | 24.3 | GO:0098532 | hepatocyte homeostasis(GO:0036333) histone H3-K27 trimethylation(GO:0098532) response to tetrachloromethane(GO:1904772) |
| 8.1 | 24.2 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
| 8.1 | 56.4 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 8.1 | 297.9 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 8.0 | 56.2 | GO:1905068 | arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 8.0 | 87.8 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
| 7.9 | 31.7 | GO:1904924 | negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924) |
| 7.7 | 30.9 | GO:0080154 | regulation of fertilization(GO:0080154) |
| 7.7 | 15.4 | GO:1902512 | positive regulation of apoptotic DNA fragmentation(GO:1902512) |
| 7.6 | 137.2 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 7.4 | 111.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 7.4 | 96.1 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 7.3 | 36.7 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 7.2 | 21.7 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 7.1 | 21.2 | GO:0071373 | cellular response to cocaine(GO:0071314) cellular response to luteinizing hormone stimulus(GO:0071373) |
| 6.9 | 130.7 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 6.8 | 129.2 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 6.8 | 33.9 | GO:2000771 | regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814) |
| 6.8 | 13.5 | GO:0018312 | peptidyl-serine ADP-ribosylation(GO:0018312) |
| 6.8 | 13.5 | GO:0090034 | regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035) |
| 6.6 | 152.6 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 6.6 | 19.7 | GO:0098507 | polynucleotide 5' dephosphorylation(GO:0098507) |
| 6.5 | 19.4 | GO:2000397 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397) |
| 6.5 | 38.7 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 6.4 | 25.8 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 6.4 | 6.4 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 6.4 | 44.8 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 6.3 | 50.6 | GO:0070071 | proton-transporting two-sector ATPase complex assembly(GO:0070071) |
| 6.3 | 25.2 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
| 6.3 | 25.2 | GO:0042247 | morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247) |
| 6.2 | 99.8 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 6.2 | 49.5 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 6.2 | 36.9 | GO:0030581 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 6.1 | 18.4 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
| 6.1 | 12.2 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 6.1 | 61.0 | GO:0046689 | response to mercury ion(GO:0046689) |
| 6.1 | 237.1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 6.1 | 42.5 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
| 6.0 | 54.0 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 6.0 | 18.0 | GO:0015798 | myo-inositol transport(GO:0015798) |
| 6.0 | 54.0 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 6.0 | 41.9 | GO:0015846 | polyamine transport(GO:0015846) |
| 5.9 | 47.6 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 5.9 | 23.7 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 5.8 | 23.4 | GO:1902775 | mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 5.8 | 23.3 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 5.8 | 29.1 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 5.8 | 370.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 5.7 | 40.2 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 5.7 | 74.6 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 5.7 | 56.9 | GO:0045116 | protein neddylation(GO:0045116) |
| 5.7 | 28.3 | GO:0000466 | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466) |
| 5.7 | 28.3 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 5.6 | 84.4 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 5.6 | 89.7 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 5.6 | 22.4 | GO:0048200 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 5.6 | 33.5 | GO:0060356 | leucine import(GO:0060356) |
| 5.6 | 22.2 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 5.5 | 11.0 | GO:0071072 | negative regulation of phospholipid biosynthetic process(GO:0071072) |
| 5.5 | 142.0 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 5.4 | 130.6 | GO:0042921 | glucocorticoid receptor signaling pathway(GO:0042921) |
| 5.4 | 48.9 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 5.3 | 26.7 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 5.3 | 26.7 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 5.3 | 37.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 5.3 | 15.8 | GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity(GO:0090176) |
| 5.3 | 73.8 | GO:0043457 | regulation of cellular respiration(GO:0043457) |
| 5.2 | 26.1 | GO:0070842 | aggresome assembly(GO:0070842) |
| 5.2 | 62.4 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 5.1 | 41.2 | GO:1903297 | regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) intrinsic apoptotic signaling pathway in response to hypoxia(GO:1990144) |
| 5.1 | 547.8 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 5.1 | 45.9 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 5.1 | 25.4 | GO:0006850 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 5.0 | 15.1 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 5.0 | 404.6 | GO:0048208 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 4.9 | 68.8 | GO:1902254 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254) |
| 4.8 | 19.1 | GO:0022614 | membrane to membrane docking(GO:0022614) negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347) |
| 4.8 | 43.0 | GO:0045176 | activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176) |
| 4.7 | 23.6 | GO:0032532 | regulation of microvillus length(GO:0032532) |
| 4.7 | 23.6 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 4.7 | 28.2 | GO:0090336 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of brown fat cell differentiation(GO:0090336) positive regulation of interleukin-12 secretion(GO:2001184) |
| 4.7 | 4.7 | GO:0090385 | phagosome-lysosome fusion(GO:0090385) |
| 4.7 | 28.2 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 4.7 | 23.4 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 4.6 | 46.3 | GO:0070525 | tRNA threonylcarbamoyladenosine metabolic process(GO:0070525) mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 4.6 | 54.9 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 4.5 | 27.2 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 4.5 | 4.5 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 4.5 | 13.5 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 4.5 | 13.4 | GO:0045896 | regulation of transcription during mitosis(GO:0045896) |
| 4.5 | 17.8 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 4.4 | 79.8 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 4.4 | 13.2 | GO:2000687 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 4.4 | 4.4 | GO:0048378 | lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) |
| 4.3 | 34.7 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 4.3 | 43.1 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 4.3 | 102.7 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 4.2 | 50.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 4.2 | 42.1 | GO:0045008 | depyrimidination(GO:0045008) |
| 4.2 | 37.7 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 4.2 | 74.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 4.1 | 140.0 | GO:0090383 | phagosome acidification(GO:0090383) |
| 4.1 | 32.8 | GO:2000773 | negative regulation of cellular senescence(GO:2000773) |
| 4.1 | 106.4 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 4.0 | 8.0 | GO:1904526 | regulation of microtubule binding(GO:1904526) |
| 4.0 | 19.9 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 4.0 | 31.7 | GO:0035518 | histone H2A monoubiquitination(GO:0035518) |
| 3.9 | 69.9 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) |
| 3.8 | 37.8 | GO:0042407 | cristae formation(GO:0042407) |
| 3.8 | 26.5 | GO:0030647 | polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598) |
| 3.8 | 7.5 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
| 3.7 | 116.2 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 3.7 | 280.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 3.7 | 40.4 | GO:0009414 | response to water deprivation(GO:0009414) |
| 3.7 | 44.1 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 3.6 | 14.5 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 3.6 | 71.9 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 3.6 | 10.7 | GO:0097032 | respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032) |
| 3.5 | 14.1 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 3.5 | 17.6 | GO:0009149 | pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213) |
| 3.5 | 13.9 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 3.5 | 27.7 | GO:0001878 | response to yeast(GO:0001878) |
| 3.4 | 20.5 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 3.4 | 44.2 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 3.4 | 23.7 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
| 3.4 | 10.1 | GO:1904387 | response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387) |
| 3.4 | 50.4 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 3.4 | 36.9 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 3.4 | 13.4 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 3.2 | 12.9 | GO:0002906 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 3.2 | 74.3 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 3.2 | 16.0 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 3.2 | 12.8 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 3.2 | 31.9 | GO:0007028 | cytoplasm organization(GO:0007028) |
| 3.2 | 107.4 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 3.2 | 25.2 | GO:0032057 | negative regulation of translational initiation in response to stress(GO:0032057) |
| 3.2 | 25.2 | GO:0046146 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 3.1 | 9.4 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 3.1 | 12.4 | GO:0090114 | COPII-coated vesicle budding(GO:0090114) |
| 3.1 | 27.9 | GO:2000582 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 3.1 | 36.9 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 3.1 | 119.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 3.1 | 21.5 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 3.1 | 12.3 | GO:0009181 | purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181) ribonucleoside diphosphate catabolic process(GO:0009191) |
| 3.0 | 39.6 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 3.0 | 30.1 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 3.0 | 9.0 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 3.0 | 62.6 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 3.0 | 11.9 | GO:1901377 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
| 3.0 | 17.8 | GO:1903003 | positive regulation of protein deubiquitination(GO:1903003) |
| 3.0 | 29.5 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 2.9 | 5.9 | GO:1903422 | negative regulation of synaptic vesicle recycling(GO:1903422) |
| 2.9 | 26.3 | GO:0051561 | positive regulation of mitochondrial calcium ion concentration(GO:0051561) |
| 2.9 | 8.7 | GO:0046719 | regulation by virus of viral protein levels in host cell(GO:0046719) |
| 2.8 | 14.2 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 2.8 | 5.7 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 2.8 | 110.1 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 2.8 | 59.2 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 2.8 | 14.1 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 2.8 | 53.3 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 2.8 | 14.0 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 2.8 | 33.5 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 2.8 | 8.4 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 2.8 | 19.5 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 2.8 | 11.1 | GO:0030047 | actin modification(GO:0030047) |
| 2.8 | 85.7 | GO:0097421 | liver regeneration(GO:0097421) |
| 2.7 | 13.7 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 2.7 | 18.9 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 2.7 | 16.1 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 2.6 | 76.4 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 2.6 | 49.8 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 2.6 | 10.4 | GO:0060463 | lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463) |
| 2.6 | 49.2 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 2.6 | 20.6 | GO:0019720 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
| 2.6 | 12.8 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 2.5 | 7.5 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 2.5 | 32.6 | GO:0009226 | nucleotide-sugar biosynthetic process(GO:0009226) |
| 2.5 | 12.5 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) |
| 2.5 | 15.0 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
| 2.5 | 15.0 | GO:0015680 | intracellular copper ion transport(GO:0015680) |
| 2.4 | 38.3 | GO:0006378 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 2.4 | 33.5 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 2.4 | 9.5 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 2.4 | 11.9 | GO:0003056 | regulation of vascular smooth muscle contraction(GO:0003056) |
| 2.4 | 19.0 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 2.4 | 18.9 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 2.3 | 47.0 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 2.3 | 11.7 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 2.3 | 11.7 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
| 2.3 | 39.6 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 2.3 | 6.9 | GO:0032707 | negative regulation of interleukin-23 production(GO:0032707) |
| 2.3 | 45.8 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 2.3 | 31.9 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 2.2 | 15.5 | GO:0048313 | Golgi inheritance(GO:0048313) |
| 2.2 | 35.4 | GO:1903539 | neurotransmitter receptor transport to plasma membrane(GO:0098877) neurotransmitter receptor transport to postsynaptic membrane(GO:0098969) protein localization to postsynaptic membrane(GO:1903539) establishment of protein localization to postsynaptic membrane(GO:1903540) |
| 2.2 | 8.8 | GO:0046946 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 2.2 | 22.0 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 2.2 | 143.0 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 2.1 | 18.9 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 2.1 | 14.6 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
| 2.1 | 14.6 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 2.1 | 20.7 | GO:0006537 | glutamate biosynthetic process(GO:0006537) |
| 2.1 | 55.5 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 2.0 | 36.7 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 2.0 | 16.2 | GO:0002759 | regulation of antimicrobial humoral response(GO:0002759) |
| 2.0 | 12.1 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 2.0 | 12.1 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 2.0 | 2.0 | GO:0098917 | retrograde trans-synaptic signaling(GO:0098917) |
| 2.0 | 27.9 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 2.0 | 6.0 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) |
| 2.0 | 95.3 | GO:0018196 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 2.0 | 15.8 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 2.0 | 5.9 | GO:0051877 | pigment granule aggregation in cell center(GO:0051877) |
| 1.9 | 36.3 | GO:0031440 | regulation of mRNA 3'-end processing(GO:0031440) |
| 1.9 | 36.1 | GO:0031063 | regulation of histone deacetylation(GO:0031063) |
| 1.9 | 15.2 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 1.9 | 39.9 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 1.9 | 20.8 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 1.9 | 26.1 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 1.9 | 31.7 | GO:0033260 | nuclear DNA replication(GO:0033260) |
| 1.9 | 11.2 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 1.9 | 7.4 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
| 1.8 | 24.0 | GO:0042274 | ribosomal small subunit biogenesis(GO:0042274) |
| 1.8 | 7.3 | GO:0042091 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 1.8 | 14.6 | GO:0001302 | replicative cell aging(GO:0001302) |
| 1.8 | 121.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 1.8 | 16.3 | GO:0030261 | chromosome condensation(GO:0030261) |
| 1.8 | 1.8 | GO:0032785 | negative regulation of DNA-templated transcription, elongation(GO:0032785) |
| 1.8 | 50.3 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 1.8 | 19.7 | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145) |
| 1.8 | 7.0 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 1.8 | 12.3 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 1.7 | 41.1 | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) |
| 1.7 | 13.6 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 1.7 | 5.1 | GO:0035425 | autocrine signaling(GO:0035425) |
| 1.7 | 20.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 1.6 | 448.5 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.6 | 57.4 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 1.6 | 84.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.6 | 48.7 | GO:0006414 | translational elongation(GO:0006414) |
| 1.6 | 61.4 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 1.6 | 17.7 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 1.6 | 16.0 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 1.6 | 122.8 | GO:0015914 | phospholipid transport(GO:0015914) |
| 1.6 | 27.0 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 1.6 | 42.4 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 1.6 | 14.1 | GO:1903543 | positive regulation of exosomal secretion(GO:1903543) |
| 1.6 | 10.9 | GO:0044800 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 1.5 | 20.1 | GO:0070828 | heterochromatin organization(GO:0070828) |
| 1.5 | 9.2 | GO:0017062 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 1.5 | 30.4 | GO:0008228 | opsonization(GO:0008228) |
| 1.5 | 19.6 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 1.5 | 4.5 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 1.5 | 11.8 | GO:0001711 | endodermal cell fate commitment(GO:0001711) |
| 1.5 | 54.6 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 1.5 | 14.7 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 1.4 | 10.1 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 1.4 | 11.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 1.4 | 176.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 1.4 | 7.0 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 1.4 | 16.6 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 1.4 | 34.3 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 1.3 | 5.4 | GO:0006415 | translational termination(GO:0006415) |
| 1.3 | 26.4 | GO:0043097 | pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097) |
| 1.3 | 47.0 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 1.3 | 15.5 | GO:1903599 | positive regulation of mitophagy(GO:1903599) |
| 1.3 | 5.2 | GO:0051683 | establishment of Golgi localization(GO:0051683) |
| 1.3 | 10.3 | GO:0006903 | vesicle targeting(GO:0006903) |
| 1.3 | 3.9 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 1.3 | 27.0 | GO:0006825 | copper ion transport(GO:0006825) |
| 1.3 | 3.8 | GO:0035522 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 1.3 | 6.3 | GO:0006655 | phosphatidylglycerol biosynthetic process(GO:0006655) |
| 1.2 | 15.9 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 1.2 | 4.9 | GO:0060666 | branchiomotor neuron axon guidance(GO:0021785) dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 1.2 | 33.8 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 1.2 | 19.3 | GO:2000828 | post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828) |
| 1.2 | 12.9 | GO:0051642 | centrosome localization(GO:0051642) |
| 1.2 | 77.1 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 1.2 | 24.3 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 1.1 | 29.6 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
| 1.1 | 2.2 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 1.1 | 28.6 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 1.1 | 16.5 | GO:0018126 | protein hydroxylation(GO:0018126) |
| 1.1 | 5.4 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 1.1 | 3.2 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 1.1 | 21.5 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 1.0 | 56.3 | GO:0006364 | rRNA processing(GO:0006364) |
| 1.0 | 7.2 | GO:0030091 | protein repair(GO:0030091) |
| 1.0 | 20.3 | GO:0048261 | negative regulation of receptor-mediated endocytosis(GO:0048261) |
| 1.0 | 7.1 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 1.0 | 16.1 | GO:0046036 | CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036) |
| 1.0 | 5.0 | GO:0019081 | viral translation(GO:0019081) |
| 1.0 | 6.0 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 1.0 | 2.0 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) |
| 1.0 | 24.0 | GO:0051893 | regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109) regulation of adherens junction organization(GO:1903391) |
| 1.0 | 18.3 | GO:0034383 | low-density lipoprotein particle clearance(GO:0034383) |
| 1.0 | 11.5 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 1.0 | 26.8 | GO:0032402 | establishment of melanosome localization(GO:0032401) melanosome transport(GO:0032402) |
| 1.0 | 12.4 | GO:0000715 | protein deneddylation(GO:0000338) nucleotide-excision repair, DNA damage recognition(GO:0000715) |
| 0.9 | 11.3 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.9 | 4.7 | GO:0051415 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.9 | 9.1 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.9 | 51.7 | GO:1901222 | regulation of NIK/NF-kappaB signaling(GO:1901222) |
| 0.9 | 35.3 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.9 | 10.8 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.9 | 34.0 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.9 | 3.5 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.9 | 13.9 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.9 | 102.4 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.8 | 1.7 | GO:0043201 | response to leucine(GO:0043201) |
| 0.8 | 4.1 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.8 | 3.1 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway(GO:0034145) |
| 0.8 | 7.6 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.8 | 8.3 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.7 | 7.4 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.7 | 39.9 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.7 | 47.2 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.7 | 3.6 | GO:1904752 | vascular associated smooth muscle cell migration(GO:1904738) regulation of vascular associated smooth muscle cell migration(GO:1904752) negative regulation of vascular associated smooth muscle cell migration(GO:1904753) |
| 0.7 | 12.0 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.7 | 54.1 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.7 | 20.7 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.7 | 2.7 | GO:0003409 | optic cup structural organization(GO:0003409) |
| 0.7 | 10.9 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.7 | 2.7 | GO:0003340 | negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340) |
| 0.7 | 12.1 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.7 | 4.6 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.7 | 5.2 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.6 | 6.5 | GO:0090382 | phagosome maturation(GO:0090382) |
| 0.6 | 7.7 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 0.6 | 15.2 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.6 | 27.6 | GO:0021795 | cerebral cortex cell migration(GO:0021795) |
| 0.6 | 3.8 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.6 | 19.8 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.6 | 6.7 | GO:0060510 | Type II pneumocyte differentiation(GO:0060510) |
| 0.6 | 11.6 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 0.6 | 61.7 | GO:0070268 | cornification(GO:0070268) |
| 0.6 | 2.9 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.5 | 10.9 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.5 | 6.4 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.5 | 6.3 | GO:0051351 | positive regulation of ligase activity(GO:0051351) |
| 0.5 | 24.7 | GO:0046949 | fatty-acyl-CoA biosynthetic process(GO:0046949) |
| 0.5 | 3.1 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.5 | 9.3 | GO:2000009 | negative regulation of protein localization to cell surface(GO:2000009) |
| 0.5 | 13.9 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.5 | 7.7 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.5 | 19.7 | GO:0007031 | peroxisome organization(GO:0007031) |
| 0.5 | 1.5 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.5 | 1.9 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.5 | 9.1 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.5 | 6.1 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.5 | 2.3 | GO:0044557 | relaxation of smooth muscle(GO:0044557) |
| 0.4 | 26.6 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.4 | 2.0 | GO:0097084 | vascular smooth muscle cell development(GO:0097084) |
| 0.4 | 4.0 | GO:0048007 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.4 | 1.9 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 0.4 | 6.6 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.4 | 5.0 | GO:0044065 | regulation of respiratory system process(GO:0044065) |
| 0.4 | 5.2 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.3 | 14.5 | GO:0031100 | organ regeneration(GO:0031100) |
| 0.3 | 1.6 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.3 | 1.5 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 0.3 | 5.1 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.3 | 49.5 | GO:0006457 | protein folding(GO:0006457) |
| 0.3 | 3.5 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.3 | 1.4 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.2 | 3.2 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
| 0.2 | 7.2 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.2 | 0.9 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.2 | 9.7 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.2 | 4.6 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.2 | 1.2 | GO:0072319 | synaptic vesicle uncoating(GO:0016191) vesicle uncoating(GO:0072319) |
| 0.2 | 2.8 | GO:0060122 | inner ear receptor stereocilium organization(GO:0060122) |
| 0.2 | 2.1 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.2 | 1.3 | GO:0099515 | vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515) |
| 0.2 | 4.3 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
| 0.2 | 5.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.2 | 0.3 | GO:0018317 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.1 | 4.0 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 0.4 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 0.1 | 2.5 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.1 | 4.0 | GO:0060416 | response to growth hormone(GO:0060416) |
| 0.1 | 2.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 3.3 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
| 0.1 | 3.9 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 1.9 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.1 | 3.5 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.1 | 0.9 | GO:0060285 | cilium-dependent cell motility(GO:0060285) |
| 0.1 | 6.0 | GO:0030166 | proteoglycan biosynthetic process(GO:0030166) |
| 0.0 | 4.7 | GO:0042278 | purine nucleoside metabolic process(GO:0042278) |
| 0.0 | 0.0 | GO:0061536 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 38.8 | 155.3 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 35.2 | 175.8 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 34.4 | 103.1 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 30.5 | 91.5 | GO:1990298 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 28.2 | 112.8 | GO:0071942 | XPC complex(GO:0071942) |
| 28.2 | 450.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 28.1 | 112.5 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 26.7 | 80.0 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 24.3 | 145.7 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 24.2 | 242.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 23.6 | 283.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 22.9 | 91.8 | GO:0005715 | late recombination nodule(GO:0005715) |
| 22.8 | 159.4 | GO:0032021 | NELF complex(GO:0032021) |
| 22.4 | 157.1 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 22.2 | 598.2 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 21.8 | 87.4 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 19.1 | 95.7 | GO:0045281 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 18.3 | 238.5 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 18.1 | 108.7 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 17.4 | 156.2 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 17.2 | 155.2 | GO:0042382 | paraspeckles(GO:0042382) |
| 16.5 | 98.8 | GO:0001940 | male pronucleus(GO:0001940) |
| 16.4 | 98.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 16.3 | 48.9 | GO:1903349 | omegasome membrane(GO:1903349) |
| 16.2 | 129.3 | GO:0005827 | polar microtubule(GO:0005827) |
| 15.8 | 47.3 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 14.7 | 29.3 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 14.6 | 102.3 | GO:0031415 | NatA complex(GO:0031415) |
| 14.5 | 72.7 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 14.1 | 84.6 | GO:0097422 | tubular endosome(GO:0097422) |
| 14.1 | 56.2 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 13.4 | 93.7 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 13.2 | 171.8 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 12.9 | 64.7 | GO:0001651 | dense fibrillar component(GO:0001651) granular component(GO:0001652) |
| 12.7 | 38.2 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 12.2 | 97.5 | GO:0000796 | condensin complex(GO:0000796) |
| 12.0 | 204.6 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 11.9 | 83.2 | GO:0072589 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 11.5 | 92.1 | GO:0031931 | TORC1 complex(GO:0031931) |
| 11.5 | 229.9 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 11.3 | 259.3 | GO:0046930 | pore complex(GO:0046930) |
| 10.9 | 32.8 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 10.8 | 216.6 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 10.7 | 86.0 | GO:0005688 | U6 snRNP(GO:0005688) |
| 10.6 | 42.6 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 10.4 | 31.3 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 10.3 | 297.9 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 10.1 | 91.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 10.1 | 50.6 | GO:0043291 | RAVE complex(GO:0043291) |
| 10.0 | 30.1 | GO:0072379 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 9.9 | 129.2 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 9.8 | 49.0 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 9.7 | 38.7 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 9.5 | 47.3 | GO:0035061 | interchromatin granule(GO:0035061) |
| 9.4 | 56.7 | GO:0000243 | commitment complex(GO:0000243) |
| 9.3 | 111.5 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 9.1 | 27.2 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 8.8 | 44.1 | GO:0089701 | U2AF(GO:0089701) |
| 8.5 | 51.2 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 8.5 | 76.3 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 8.1 | 40.7 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 8.1 | 24.3 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 8.0 | 71.9 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 7.9 | 62.8 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 7.8 | 46.9 | GO:1990357 | terminal web(GO:1990357) |
| 7.7 | 38.4 | GO:0032302 | MutSalpha complex(GO:0032301) MutSbeta complex(GO:0032302) |
| 7.6 | 53.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 7.6 | 68.3 | GO:0032797 | SMN complex(GO:0032797) |
| 7.4 | 74.5 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 7.3 | 80.1 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 7.1 | 199.9 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 7.1 | 71.0 | GO:0097255 | R2TP complex(GO:0097255) |
| 7.1 | 28.3 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 7.0 | 126.6 | GO:0032433 | filopodium tip(GO:0032433) |
| 6.9 | 55.5 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 6.8 | 156.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 6.8 | 27.0 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 6.7 | 26.8 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 6.6 | 132.1 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 6.6 | 19.8 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 6.6 | 72.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 6.5 | 640.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 6.5 | 78.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 6.5 | 32.3 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 6.5 | 226.0 | GO:0071565 | nBAF complex(GO:0071565) |
| 6.5 | 83.9 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 6.4 | 70.1 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 6.3 | 6.3 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 6.3 | 346.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 6.3 | 37.6 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 6.2 | 56.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 6.1 | 18.2 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 6.0 | 30.2 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
| 5.8 | 174.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 5.8 | 46.3 | GO:0005686 | U2 snRNP(GO:0005686) |
| 5.7 | 17.0 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) |
| 5.6 | 157.8 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 5.4 | 87.1 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 5.4 | 10.9 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 5.4 | 27.0 | GO:1990425 | ryanodine receptor complex(GO:1990425) |
| 5.4 | 32.3 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 5.4 | 64.3 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
| 5.3 | 36.8 | GO:0005818 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 5.1 | 41.2 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 5.0 | 35.3 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 5.0 | 25.2 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 5.0 | 50.0 | GO:0090543 | Flemming body(GO:0090543) |
| 5.0 | 19.9 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 4.9 | 59.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 4.9 | 43.8 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 4.8 | 28.9 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 4.8 | 14.5 | GO:0005745 | m-AAA complex(GO:0005745) |
| 4.8 | 33.6 | GO:0000812 | Swr1 complex(GO:0000812) |
| 4.8 | 124.6 | GO:0005844 | polysome(GO:0005844) |
| 4.7 | 47.4 | GO:0031465 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 4.7 | 51.4 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 4.6 | 13.9 | GO:0055087 | Ski complex(GO:0055087) |
| 4.6 | 50.9 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 4.6 | 18.4 | GO:0071986 | Ragulator complex(GO:0071986) |
| 4.6 | 41.3 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 4.6 | 13.7 | GO:0005816 | spindle pole body(GO:0005816) |
| 4.6 | 256.1 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 4.3 | 112.8 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 4.3 | 8.6 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 4.3 | 17.1 | GO:0071817 | MMXD complex(GO:0071817) |
| 4.2 | 63.7 | GO:0000346 | transcription export complex(GO:0000346) |
| 4.2 | 25.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 4.2 | 75.6 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 4.1 | 33.2 | GO:0070187 | telosome(GO:0070187) |
| 4.0 | 24.1 | GO:0061617 | MICOS complex(GO:0061617) |
| 3.9 | 94.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 3.9 | 58.5 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 3.8 | 53.8 | GO:0005869 | dynactin complex(GO:0005869) |
| 3.7 | 147.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 3.7 | 58.6 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 3.6 | 14.5 | GO:0044307 | dendritic branch(GO:0044307) |
| 3.6 | 25.2 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 3.5 | 93.7 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 3.5 | 27.7 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 3.4 | 217.0 | GO:0072686 | mitotic spindle(GO:0072686) |
| 3.4 | 37.9 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 3.4 | 17.2 | GO:0033176 | proton-transporting V-type ATPase complex(GO:0033176) |
| 3.4 | 37.2 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 3.4 | 10.1 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 3.3 | 10.0 | GO:0033565 | ESCRT-0 complex(GO:0033565) |
| 3.3 | 36.4 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 3.3 | 138.7 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 3.2 | 38.8 | GO:0030008 | TRAPP complex(GO:0030008) |
| 3.1 | 12.4 | GO:0070876 | SOSS complex(GO:0070876) |
| 3.0 | 6.1 | GO:0031414 | N-terminal protein acetyltransferase complex(GO:0031414) |
| 3.0 | 78.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 3.0 | 15.0 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 3.0 | 27.0 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 3.0 | 35.7 | GO:0097346 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) INO80-type complex(GO:0097346) |
| 3.0 | 74.3 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 3.0 | 23.7 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 2.9 | 43.8 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 2.9 | 14.5 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 2.9 | 26.0 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 2.8 | 22.5 | GO:0000153 | cytoplasmic ubiquitin ligase complex(GO:0000153) |
| 2.8 | 11.1 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 2.7 | 13.5 | GO:0016589 | NURF complex(GO:0016589) |
| 2.7 | 21.6 | GO:0031371 | ubiquitin conjugating enzyme complex(GO:0031371) |
| 2.7 | 29.6 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 2.6 | 15.7 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 2.6 | 18.4 | GO:1990635 | proximal dendrite(GO:1990635) |
| 2.6 | 15.6 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 2.6 | 7.8 | GO:0072487 | MSL complex(GO:0072487) |
| 2.5 | 256.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.5 | 20.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 2.4 | 26.5 | GO:0042555 | MCM complex(GO:0042555) |
| 2.4 | 12.1 | GO:0032044 | DSIF complex(GO:0032044) |
| 2.4 | 298.1 | GO:0005840 | ribosome(GO:0005840) |
| 2.4 | 57.2 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 2.4 | 66.5 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 2.3 | 18.5 | GO:0071203 | WASH complex(GO:0071203) |
| 2.3 | 105.2 | GO:0000502 | proteasome complex(GO:0000502) |
| 2.3 | 13.7 | GO:0016272 | prefoldin complex(GO:0016272) |
| 2.1 | 44.0 | GO:0097342 | ripoptosome(GO:0097342) |
| 2.1 | 8.4 | GO:1990075 | periciliary membrane compartment(GO:1990075) |
| 2.1 | 12.5 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 2.1 | 6.2 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 2.0 | 20.5 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 2.0 | 11.9 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 2.0 | 5.9 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 2.0 | 5.9 | GO:0060091 | kinocilium(GO:0060091) kinociliary basal body(GO:1902636) |
| 2.0 | 15.8 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 1.9 | 7.6 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 1.8 | 29.3 | GO:0031332 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 1.8 | 27.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 1.8 | 10.6 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 1.7 | 37.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 1.7 | 34.3 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 1.7 | 275.3 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 1.7 | 8.4 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 1.7 | 65.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 1.7 | 132.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 1.6 | 11.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 1.6 | 38.9 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 1.5 | 6.2 | GO:0043541 | UDP-N-acetylglucosamine transferase complex(GO:0043541) |
| 1.5 | 21.4 | GO:0097526 | U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526) |
| 1.4 | 43.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.4 | 5.7 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 1.4 | 12.8 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 1.4 | 79.2 | GO:0045171 | intercellular bridge(GO:0045171) |
| 1.4 | 62.1 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 1.4 | 22.5 | GO:0097470 | ribbon synapse(GO:0097470) |
| 1.4 | 18.2 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 1.4 | 5.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 1.4 | 67.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.4 | 5.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 1.3 | 5.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 1.3 | 5.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 1.3 | 3.8 | GO:0035517 | PR-DUB complex(GO:0035517) |
| 1.3 | 85.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 1.3 | 6.3 | GO:0000306 | extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313) |
| 1.2 | 33.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 1.2 | 7.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 1.2 | 11.8 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 1.2 | 36.4 | GO:0005921 | gap junction(GO:0005921) |
| 1.2 | 18.5 | GO:0030904 | retromer complex(GO:0030904) |
| 1.1 | 14.7 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 1.1 | 560.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 1.1 | 20.1 | GO:0044815 | DNA packaging complex(GO:0044815) |
| 1.1 | 21.0 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 1.0 | 7.2 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 1.0 | 169.4 | GO:0031968 | organelle outer membrane(GO:0031968) |
| 1.0 | 6.7 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.9 | 7.5 | GO:0070522 | ERCC4-ERCC1 complex(GO:0070522) |
| 0.9 | 9.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.9 | 21.2 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.9 | 3.6 | GO:0005846 | nuclear cap binding complex(GO:0005846) |
| 0.9 | 5.3 | GO:0030681 | multimeric ribonuclease P complex(GO:0030681) |
| 0.9 | 33.4 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.8 | 61.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.8 | 43.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.8 | 55.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.8 | 4.1 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.8 | 15.3 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.7 | 7.4 | GO:0038201 | TORC2 complex(GO:0031932) TOR complex(GO:0038201) |
| 0.7 | 83.3 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.7 | 4.9 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.7 | 20.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.7 | 2.1 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 0.7 | 8.8 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.7 | 4.1 | GO:0000145 | exocyst(GO:0000145) |
| 0.7 | 67.5 | GO:0016605 | PML body(GO:0016605) |
| 0.6 | 7.0 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.6 | 68.6 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.6 | 64.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.6 | 12.5 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.6 | 7.7 | GO:0032059 | bleb(GO:0032059) |
| 0.6 | 14.7 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.6 | 9.3 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.6 | 17.9 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.6 | 16.5 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.6 | 46.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.6 | 10.1 | GO:0044453 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.6 | 1.7 | GO:0034271 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.5 | 158.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.5 | 21.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.5 | 110.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.5 | 371.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.4 | 30.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.4 | 4.4 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.4 | 27.2 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.4 | 5.2 | GO:0000974 | Prp19 complex(GO:0000974) |
| 0.4 | 58.6 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.4 | 6.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.4 | 26.0 | GO:0030496 | midbody(GO:0030496) |
| 0.3 | 5.9 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 12.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.3 | 23.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.3 | 2.0 | GO:0043196 | varicosity(GO:0043196) |
| 0.3 | 4.0 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.3 | 1.1 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
| 0.3 | 1.4 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.3 | 2.0 | GO:0016012 | dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012) |
| 0.2 | 9.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.2 | 455.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 4.2 | GO:0036379 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.1 | 0.5 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 0.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.1 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 52.2 | 313.1 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 44.0 | 132.1 | GO:0004638 | phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639) |
| 34.9 | 104.7 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 34.5 | 275.9 | GO:0015288 | porin activity(GO:0015288) |
| 33.1 | 99.2 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
| 31.2 | 561.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 28.0 | 28.0 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 27.6 | 82.7 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 26.9 | 242.3 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 26.8 | 535.0 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 23.9 | 95.7 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 22.4 | 134.7 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 22.4 | 89.6 | GO:0045127 | N-acetylglucosamine kinase activity(GO:0045127) |
| 22.3 | 67.0 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 22.3 | 89.1 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 20.6 | 103.1 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 20.3 | 60.8 | GO:0003896 | DNA primase activity(GO:0003896) |
| 20.2 | 100.9 | GO:0010340 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 19.9 | 239.2 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 19.7 | 19.7 | GO:0004651 | polynucleotide 5'-phosphatase activity(GO:0004651) |
| 19.5 | 175.8 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 19.4 | 116.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 18.7 | 56.1 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 18.4 | 92.2 | GO:0003870 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 17.7 | 53.2 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
| 17.7 | 70.9 | GO:0043262 | adenosine-diphosphatase activity(GO:0043262) |
| 17.5 | 227.0 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 17.3 | 190.2 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 16.8 | 83.9 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 16.6 | 132.6 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 16.0 | 64.0 | GO:0003883 | CTP synthase activity(GO:0003883) |
| 15.4 | 108.1 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 15.3 | 45.8 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 15.2 | 91.2 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 14.9 | 89.7 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 14.9 | 74.5 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 14.8 | 44.3 | GO:0043035 | chromatin insulator sequence binding(GO:0043035) |
| 14.5 | 72.7 | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066) |
| 13.8 | 41.3 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 13.6 | 40.9 | GO:0070361 | mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364) |
| 13.6 | 217.2 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 13.5 | 40.6 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 13.5 | 134.8 | GO:0051425 | PTB domain binding(GO:0051425) |
| 13.3 | 66.6 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
| 13.0 | 64.8 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 12.9 | 232.7 | GO:0030957 | Tat protein binding(GO:0030957) |
| 12.8 | 141.1 | GO:0003720 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 12.7 | 63.4 | GO:1990446 | U1 snRNA binding(GO:0030619) U1 snRNP binding(GO:1990446) |
| 12.7 | 50.6 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 12.4 | 61.8 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 12.2 | 61.2 | GO:0004082 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 12.1 | 72.4 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 12.0 | 372.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 12.0 | 71.9 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 12.0 | 71.8 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 12.0 | 12.0 | GO:0032551 | pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551) |
| 11.8 | 35.4 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 11.6 | 80.9 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 11.2 | 111.5 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 11.0 | 44.0 | GO:0002060 | purine nucleobase binding(GO:0002060) |
| 10.9 | 130.2 | GO:0032137 | guanine/thymine mispair binding(GO:0032137) |
| 10.8 | 184.3 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 10.8 | 32.5 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 10.6 | 63.9 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 10.6 | 42.4 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
| 10.5 | 126.3 | GO:0030911 | TPR domain binding(GO:0030911) |
| 10.4 | 41.7 | GO:1990189 | peptide-serine-N-acetyltransferase activity(GO:1990189) |
| 10.1 | 40.3 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
| 9.9 | 88.8 | GO:0018812 | 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) |
| 9.7 | 272.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 9.7 | 48.5 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 9.7 | 38.7 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 9.6 | 125.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 9.5 | 95.5 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 9.5 | 38.0 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 9.4 | 65.8 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 9.3 | 102.0 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 9.2 | 36.9 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 9.2 | 27.5 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 8.9 | 80.3 | GO:0055104 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 8.6 | 25.8 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 8.5 | 110.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 8.4 | 25.2 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
| 8.3 | 74.5 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 7.9 | 55.4 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 7.9 | 47.3 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 7.9 | 55.0 | GO:0004457 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 7.9 | 94.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 7.7 | 254.3 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 7.5 | 30.0 | GO:0043515 | kinetochore binding(GO:0043515) |
| 7.5 | 52.2 | GO:0051022 | GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 7.0 | 20.9 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 6.9 | 20.6 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 6.8 | 40.5 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 6.7 | 127.9 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 6.7 | 26.9 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 6.7 | 360.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 6.6 | 13.1 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 6.5 | 32.3 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 6.4 | 25.5 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 6.3 | 56.5 | GO:0089720 | caspase binding(GO:0089720) |
| 6.2 | 74.3 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 6.1 | 18.4 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 6.1 | 18.4 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 6.0 | 42.1 | GO:0097506 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 6.0 | 125.5 | GO:0035173 | histone kinase activity(GO:0035173) |
| 5.9 | 279.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 5.8 | 29.2 | GO:0017018 | myosin phosphatase activity(GO:0017018) |
| 5.8 | 17.4 | GO:0016896 | exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896) |
| 5.8 | 40.5 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 5.8 | 75.2 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 5.7 | 28.6 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 5.6 | 33.7 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 5.6 | 39.0 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 5.5 | 27.5 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 5.4 | 27.2 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 5.4 | 16.1 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 5.2 | 25.9 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 5.2 | 20.7 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 5.1 | 41.2 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 5.1 | 40.8 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 5.1 | 30.6 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 5.0 | 25.1 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 5.0 | 15.0 | GO:0008169 | C-methyltransferase activity(GO:0008169) |
| 5.0 | 44.9 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 4.9 | 93.4 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 4.8 | 14.5 | GO:0031626 | beta-endorphin binding(GO:0031626) |
| 4.8 | 4.8 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 4.7 | 14.2 | GO:0055100 | adiponectin binding(GO:0055100) |
| 4.7 | 14.2 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 4.7 | 51.2 | GO:0015266 | protein channel activity(GO:0015266) |
| 4.6 | 46.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 4.6 | 18.3 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 4.5 | 112.7 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 4.5 | 13.4 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 4.5 | 31.4 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 4.4 | 31.0 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 4.4 | 26.5 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 4.4 | 21.9 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 4.4 | 21.9 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 4.4 | 47.9 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 4.3 | 82.4 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 4.3 | 42.9 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 4.3 | 63.9 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 4.2 | 270.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 4.2 | 54.3 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 4.1 | 20.7 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 4.1 | 185.9 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 4.1 | 32.5 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 4.0 | 32.0 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 4.0 | 75.8 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 4.0 | 11.9 | GO:0034416 | bisphosphoglycerate phosphatase activity(GO:0034416) |
| 3.9 | 129.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 3.9 | 11.6 | GO:0070704 | C-5 sterol desaturase activity(GO:0000248) sterol desaturase activity(GO:0070704) |
| 3.9 | 92.7 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 3.8 | 88.1 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 3.8 | 116.3 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 3.7 | 15.0 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 3.7 | 11.1 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 3.7 | 18.3 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 3.6 | 32.6 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 3.6 | 101.0 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 3.6 | 14.3 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 3.6 | 60.4 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 3.5 | 17.6 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 3.5 | 48.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 3.4 | 20.6 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 3.4 | 10.1 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 3.3 | 168.2 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 3.3 | 9.8 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 3.2 | 101.8 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 3.1 | 62.5 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 3.1 | 21.6 | GO:0000182 | rDNA binding(GO:0000182) |
| 3.1 | 52.1 | GO:0008143 | poly(A) binding(GO:0008143) |
| 3.0 | 12.1 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 3.0 | 11.8 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 2.9 | 58.8 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 2.9 | 104.9 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 2.9 | 31.9 | GO:0016892 | endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 2.9 | 8.7 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 2.9 | 120.8 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 2.9 | 14.3 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 2.8 | 36.9 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 2.8 | 16.8 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
| 2.8 | 30.5 | GO:0048156 | tau protein binding(GO:0048156) |
| 2.8 | 35.8 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 2.7 | 543.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.7 | 74.9 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 2.6 | 12.9 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 2.6 | 17.9 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 2.5 | 48.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 2.5 | 30.4 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 2.5 | 2.5 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 2.5 | 7.6 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 2.5 | 15.1 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 2.5 | 17.4 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 2.5 | 19.7 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 2.4 | 34.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 2.4 | 24.3 | GO:0070878 | primary miRNA binding(GO:0070878) |
| 2.4 | 41.0 | GO:0051400 | BH domain binding(GO:0051400) |
| 2.4 | 52.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 2.4 | 11.9 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 2.4 | 11.8 | GO:0030332 | cyclin binding(GO:0030332) |
| 2.3 | 65.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 2.3 | 9.3 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 2.3 | 85.3 | GO:0031491 | nucleosome binding(GO:0031491) |
| 2.2 | 22.4 | GO:0003988 | acetyl-CoA C-acyltransferase activity(GO:0003988) |
| 2.2 | 49.2 | GO:0044769 | hydrogen-exporting ATPase activity(GO:0036442) ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 2.2 | 11.2 | GO:0016936 | galactoside binding(GO:0016936) |
| 2.2 | 70.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 2.2 | 33.1 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 2.2 | 8.8 | GO:0033823 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211) |
| 2.1 | 34.2 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 2.0 | 14.3 | GO:0050733 | RS domain binding(GO:0050733) |
| 2.0 | 64.7 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 2.0 | 29.8 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 2.0 | 67.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 2.0 | 74.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 2.0 | 17.7 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 2.0 | 17.6 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
| 1.9 | 111.7 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 1.9 | 7.5 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 1.9 | 15.1 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 1.9 | 37.1 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 1.8 | 22.1 | GO:0000339 | RNA cap binding(GO:0000339) |
| 1.8 | 23.7 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 1.8 | 58.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 1.8 | 45.7 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 1.8 | 7.0 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 1.7 | 5.2 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 1.7 | 189.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 1.7 | 116.4 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 1.7 | 25.8 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 1.7 | 20.6 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 1.7 | 8.5 | GO:0004161 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 1.7 | 33.9 | GO:0000049 | tRNA binding(GO:0000049) |
| 1.7 | 66.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 1.7 | 18.2 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 1.6 | 44.9 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 1.6 | 20.3 | GO:0031996 | thioesterase binding(GO:0031996) |
| 1.5 | 4.6 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 1.5 | 15.1 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 1.5 | 35.8 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 1.5 | 7.4 | GO:0047066 | phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066) |
| 1.5 | 28.2 | GO:0017166 | vinculin binding(GO:0017166) |
| 1.5 | 71.8 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 1.4 | 31.8 | GO:0005537 | mannose binding(GO:0005537) |
| 1.4 | 7.2 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 1.4 | 7.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 1.4 | 8.6 | GO:0034511 | U3 snoRNA binding(GO:0034511) |
| 1.4 | 18.5 | GO:0043295 | glutathione binding(GO:0043295) |
| 1.4 | 10.8 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 1.4 | 12.2 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 1.3 | 18.9 | GO:0070403 | NAD+ binding(GO:0070403) |
| 1.3 | 13.4 | GO:0046790 | virion binding(GO:0046790) |
| 1.3 | 310.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.3 | 20.3 | GO:0005351 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) |
| 1.3 | 20.2 | GO:0043022 | ribosome binding(GO:0043022) |
| 1.2 | 1.2 | GO:0016420 | [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420) |
| 1.2 | 19.6 | GO:0000150 | recombinase activity(GO:0000150) |
| 1.2 | 37.9 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 1.2 | 27.7 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 1.2 | 15.6 | GO:0019104 | DNA N-glycosylase activity(GO:0019104) |
| 1.2 | 25.1 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 1.2 | 14.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 1.2 | 68.0 | GO:0019213 | deacetylase activity(GO:0019213) |
| 1.2 | 11.5 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 1.1 | 21.3 | GO:0019843 | rRNA binding(GO:0019843) |
| 1.1 | 2.2 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 1.1 | 316.3 | GO:0044389 | ubiquitin-like protein ligase binding(GO:0044389) |
| 1.1 | 16.1 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 1.1 | 6.4 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 1.0 | 54.5 | GO:0035064 | methylated histone binding(GO:0035064) |
| 1.0 | 11.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.9 | 10.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.9 | 9.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.9 | 73.9 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.9 | 51.9 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.9 | 4.5 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.9 | 3.6 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.9 | 6.0 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.9 | 20.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.9 | 17.1 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.8 | 10.9 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.8 | 10.7 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.8 | 7.4 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.8 | 6.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.8 | 4.8 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.8 | 9.2 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.8 | 8.3 | GO:0070567 | cytidylyltransferase activity(GO:0070567) |
| 0.7 | 2.2 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.7 | 15.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.7 | 7.9 | GO:0005112 | Notch binding(GO:0005112) |
| 0.7 | 2.9 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.7 | 16.1 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.7 | 6.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.7 | 47.7 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.7 | 4.7 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.7 | 26.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.7 | 9.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.6 | 3.2 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
| 0.6 | 21.4 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.6 | 22.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.6 | 15.1 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.6 | 16.6 | GO:0043531 | ADP binding(GO:0043531) |
| 0.5 | 8.2 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.5 | 9.5 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.5 | 22.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.5 | 18.1 | GO:0004386 | helicase activity(GO:0004386) |
| 0.4 | 7.6 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
| 0.4 | 14.4 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.4 | 9.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.4 | 5.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.4 | 6.3 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.4 | 18.7 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.4 | 17.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.3 | 30.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 10.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.3 | 49.4 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.3 | 16.6 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.3 | 7.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.3 | 13.9 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.3 | 2.0 | GO:1901567 | icosanoid binding(GO:0050542) icosatetraenoic acid binding(GO:0050543) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.3 | 8.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 4.1 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.3 | 1.8 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.3 | 8.4 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.3 | 3.3 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
| 0.2 | 4.0 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.2 | 5.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.2 | 6.2 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.2 | 26.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 3.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.2 | 5.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 8.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 12.5 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.2 | 51.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 3.9 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.2 | 2.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 1.2 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
| 0.2 | 6.2 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.2 | 6.9 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.2 | 2.1 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.2 | 4.0 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.2 | 6.3 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.2 | 2.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 10.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.2 | 36.3 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.1 | 3.5 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 1.5 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 3.3 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 141.1 | GO:0003723 | RNA binding(GO:0003723) |
| 0.1 | 13.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 2.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 1.7 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 0.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 6.0 | GO:0008237 | metallopeptidase activity(GO:0008237) |
| 0.0 | 1.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.9 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.0 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.4 | 531.4 | PID BARD1 PATHWAY | BARD1 signaling events |
| 8.1 | 592.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 8.0 | 222.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 6.6 | 170.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 6.3 | 221.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 5.5 | 16.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 5.3 | 189.6 | PID ATM PATHWAY | ATM pathway |
| 4.5 | 248.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 4.3 | 168.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 3.5 | 169.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 3.3 | 263.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 3.2 | 261.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 3.1 | 87.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 3.0 | 164.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 2.7 | 345.0 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 2.5 | 133.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 2.4 | 31.3 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 2.4 | 33.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 2.2 | 98.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 2.1 | 145.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 2.1 | 166.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 2.1 | 8.3 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 2.0 | 213.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.0 | 50.4 | PID ATR PATHWAY | ATR signaling pathway |
| 2.0 | 74.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 1.9 | 66.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 1.8 | 56.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 1.7 | 83.3 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 1.5 | 18.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 1.3 | 27.6 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 1.2 | 74.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.2 | 41.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 1.2 | 24.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 1.2 | 18.0 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 1.2 | 70.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 1.2 | 20.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 1.2 | 28.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 1.1 | 34.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 1.0 | 33.0 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 1.0 | 6.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.0 | 38.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 1.0 | 13.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.9 | 41.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.9 | 18.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.9 | 18.9 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.8 | 60.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.8 | 47.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.8 | 7.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.7 | 36.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.7 | 4.4 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.7 | 11.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.6 | 33.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.6 | 12.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.6 | 27.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.6 | 29.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 26.9 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.5 | 6.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.5 | 23.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.5 | 11.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.5 | 18.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.5 | 20.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.5 | 17.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.5 | 11.5 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.4 | 27.9 | PID P73PATHWAY | p73 transcription factor network |
| 0.4 | 10.6 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.4 | 4.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.3 | 87.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 4.8 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.3 | 4.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 6.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 1.5 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 19.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 1.2 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 5.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.3 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.5 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.9 | 457.2 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 18.9 | 18.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 18.7 | 243.4 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 14.1 | 28.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 12.0 | 191.9 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 11.9 | 274.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 10.0 | 360.7 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 9.8 | 147.6 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 9.8 | 185.7 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 9.8 | 244.2 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 9.7 | 328.2 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 9.1 | 164.0 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 8.9 | 204.1 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 8.7 | 105.0 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 8.5 | 42.5 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 8.3 | 49.7 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 8.2 | 230.7 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 8.2 | 262.4 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 7.7 | 15.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 7.7 | 99.8 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 7.6 | 22.9 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 7.6 | 639.3 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 7.6 | 83.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 7.5 | 82.8 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 7.1 | 128.6 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 7.1 | 604.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 6.8 | 122.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 6.8 | 27.2 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 6.7 | 80.9 | REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX | Genes involved in CDT1 association with the CDC6:ORC:origin complex |
| 6.7 | 20.1 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 6.4 | 158.8 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 6.1 | 178.3 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 6.0 | 78.1 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 5.8 | 168.9 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 5.7 | 130.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 5.3 | 80.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 5.3 | 309.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 5.3 | 148.1 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 5.1 | 92.7 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 5.1 | 194.9 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 5.1 | 75.9 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 4.8 | 352.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 4.8 | 120.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 4.8 | 82.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 4.8 | 129.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 4.8 | 95.6 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 4.5 | 27.2 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 4.5 | 125.7 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 4.5 | 107.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 4.3 | 43.4 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 4.3 | 38.8 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 4.1 | 33.2 | REACTOME TELOMERE MAINTENANCE | Genes involved in Telomere Maintenance |
| 4.1 | 8.3 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 3.7 | 160.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 3.7 | 171.6 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 3.4 | 41.3 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 3.4 | 47.9 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 3.4 | 270.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.4 | 13.6 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 3.4 | 44.0 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 3.3 | 520.4 | REACTOME TRANSLATION | Genes involved in Translation |
| 3.2 | 87.1 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 3.1 | 49.9 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 3.1 | 68.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 3.1 | 189.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 3.0 | 72.9 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 3.0 | 27.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 3.0 | 262.3 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 3.0 | 53.3 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 2.8 | 38.7 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 2.7 | 210.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.4 | 33.7 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 2.4 | 75.7 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 2.2 | 63.2 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 2.1 | 64.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 2.0 | 49.1 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 2.0 | 12.1 | REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | Genes involved in Formation of the HIV-1 Early Elongation Complex |
| 1.9 | 33.1 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 1.9 | 15.5 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 1.8 | 38.8 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 1.8 | 35.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 1.7 | 33.2 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 1.7 | 28.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 1.6 | 16.0 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 1.6 | 37.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 1.6 | 53.0 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |
| 1.5 | 11.6 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 1.4 | 14.2 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 1.3 | 55.9 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 1.3 | 40.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 1.3 | 186.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.3 | 45.9 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 1.3 | 41.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.2 | 20.8 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 1.2 | 34.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 1.1 | 13.8 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 1.1 | 18.6 | REACTOME DEADENYLATION DEPENDENT MRNA DECAY | Genes involved in Deadenylation-dependent mRNA decay |
| 1.1 | 63.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 1.0 | 3.1 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 1.0 | 34.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.9 | 63.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.9 | 26.8 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.9 | 27.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.9 | 13.7 | REACTOME HOST INTERACTIONS OF HIV FACTORS | Genes involved in Host Interactions of HIV factors |
| 0.8 | 12.6 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.8 | 21.6 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.8 | 7.5 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.7 | 13.5 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.7 | 24.6 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.6 | 18.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.6 | 10.8 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.5 | 61.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.5 | 19.1 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.5 | 8.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.4 | 7.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.4 | 3.4 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.4 | 2.5 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.3 | 7.7 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.3 | 6.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 4.4 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.3 | 12.4 | REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION | Genes involved in Post-translational protein modification |
| 0.3 | 15.5 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.2 | 3.3 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 2.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 6.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 8.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 6.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 7.1 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 4.0 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.2 | 6.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 3.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 8.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 8.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 2.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 12.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.9 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |