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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
Z-value: 0.67
Motif logo
Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
OTP
|
ENSG00000171540.8 | OTP |
|
PHOX2B
|
ENSG00000109132.7 | PHOX2B |
|
LHX1
|
ENSG00000273706.5 | LHX1 |
|
LMX1A
|
ENSG00000162761.14 | LMX1A |
|
LHX5
|
ENSG00000089116.4 | LHX5 |
|
HOXC4
|
ENSG00000198353.8 | HOXC4 |
|
HOXC4
|
ENSG00000198353.8 | HOXC4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PHOX2B | hg38_v1_chr4_-_41748713_41748731 | -0.27 | 4.8e-05 | Click! |
| LHX5 | hg38_v1_chr12_-_113471851_113471876 | -0.18 | 9.0e-03 | Click! |
| HOXC4 | hg38_v1_chr12_+_54053815_54053875 | -0.15 | 2.3e-02 | Click! |
Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif
Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 14.5 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 2.6 | 10.3 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 2.5 | 47.7 | GO:0003334 | keratinocyte development(GO:0003334) |
| 2.1 | 6.2 | GO:0061011 | hepatic duct development(GO:0061011) |
| 1.1 | 3.3 | GO:0002305 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
| 0.8 | 2.5 | GO:1903015 | regulation of exo-alpha-sialidase activity(GO:1903015) |
| 0.8 | 3.4 | GO:0032072 | plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426) |
| 0.7 | 5.9 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.7 | 14.4 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.6 | 4.5 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.6 | 4.0 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.6 | 4.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.5 | 1.6 | GO:0036510 | trimming of terminal mannose on C branch(GO:0036510) |
| 0.4 | 2.1 | GO:0031291 | Ran protein signal transduction(GO:0031291) |
| 0.4 | 1.2 | GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
| 0.3 | 1.0 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.3 | 4.1 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.3 | 1.6 | GO:0050955 | thermoception(GO:0050955) |
| 0.3 | 1.3 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 0.3 | 1.9 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) regulation of collagen catabolic process(GO:0010710) |
| 0.3 | 1.8 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.3 | 1.5 | GO:0010746 | regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
| 0.3 | 1.8 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.2 | 0.7 | GO:0001868 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.2 | 2.1 | GO:0045040 | protein import into mitochondrial outer membrane(GO:0045040) |
| 0.2 | 12.5 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.2 | 0.7 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.2 | 1.1 | GO:0006574 | valine catabolic process(GO:0006574) |
| 0.2 | 0.6 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 0.2 | 0.6 | GO:0031455 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.2 | 4.8 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.2 | 1.5 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.2 | 0.8 | GO:0043126 | regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128) |
| 0.2 | 1.3 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.1 | 1.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 0.8 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.1 | 0.7 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.1 | 1.0 | GO:1901187 | regulation of ephrin receptor signaling pathway(GO:1901187) |
| 0.1 | 1.5 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.1 | 4.1 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 0.3 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.1 | 0.8 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.1 | 0.4 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.1 | 4.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.1 | 1.4 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 0.2 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.1 | 1.6 | GO:0030728 | ovulation(GO:0030728) |
| 0.1 | 1.0 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.1 | 0.4 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 0.3 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.0 | 1.0 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 0.1 | GO:0036233 | glycine import(GO:0036233) |
| 0.0 | 0.7 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) negative regulation of activated T cell proliferation(GO:0046007) negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.6 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 2.0 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 0.3 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.0 | 0.3 | GO:0016139 | glycoside catabolic process(GO:0016139) |
| 0.0 | 1.3 | GO:0030033 | microvillus assembly(GO:0030033) |
| 0.0 | 0.2 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.0 | 0.3 | GO:1902739 | interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741) |
| 0.0 | 0.3 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.0 | 0.4 | GO:0048625 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.0 | 0.2 | GO:0045617 | negative regulation of keratinocyte differentiation(GO:0045617) |
| 0.0 | 0.2 | GO:0010643 | cell communication by chemical coupling(GO:0010643) |
| 0.0 | 4.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.1 | GO:0009085 | lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) |
| 0.0 | 1.6 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 1.7 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 3.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 1.2 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.2 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.0 | 0.2 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.0 | 1.8 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.4 | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) |
| 0.0 | 0.7 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.0 | 0.1 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.3 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.0 | 1.0 | GO:0050850 | positive regulation of calcium-mediated signaling(GO:0050850) |
| 0.0 | 2.2 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 0.1 | GO:0048840 | otolith development(GO:0048840) |
| 0.0 | 0.9 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.5 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 1.5 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.0 | 0.2 | GO:0042832 | defense response to protozoan(GO:0042832) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 10.3 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 1.1 | 4.5 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.9 | 47.7 | GO:0002102 | podosome(GO:0002102) |
| 0.6 | 4.5 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.6 | 1.9 | GO:0034677 | integrin alpha7-beta1 complex(GO:0034677) |
| 0.4 | 5.6 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.4 | 4.0 | GO:0043203 | axon hillock(GO:0043203) |
| 0.3 | 4.7 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.3 | 1.4 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.3 | 1.6 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.3 | 2.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.2 | 0.9 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 0.2 | 0.6 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.2 | 4.1 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.2 | 1.0 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 14.3 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 1.3 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 2.5 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 0.6 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.1 | 3.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 1.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 0.7 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.1 | 14.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 0.2 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.1 | 1.6 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 0.3 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 7.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 4.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.3 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.0 | 1.1 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.5 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 1.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 4.1 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.7 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 3.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 4.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 3.4 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 3.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.5 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 2.0 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.8 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.3 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 1.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 1.3 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.3 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.4 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 14.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 2.9 | 14.4 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 2.0 | 46.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 1.7 | 10.3 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 1.1 | 4.5 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.5 | 3.4 | GO:0010858 | calcium-dependent protein kinase regulator activity(GO:0010858) |
| 0.4 | 2.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.4 | 1.1 | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity(GO:0003860) |
| 0.3 | 6.2 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.2 | 2.5 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.2 | 1.4 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.2 | 1.1 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.2 | 1.6 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.2 | 1.8 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.2 | 3.6 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.2 | 2.1 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.2 | 1.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.2 | 1.4 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 5.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 0.3 | GO:0052795 | exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796) |
| 0.1 | 4.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 0.3 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.1 | 0.4 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.1 | 0.3 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.1 | 1.5 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.1 | 5.8 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 0.3 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.1 | 0.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 0.6 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.1 | 4.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 5.6 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 0.3 | GO:0016418 | S-acetyltransferase activity(GO:0016418) |
| 0.1 | 1.5 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.1 | 0.3 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 4.8 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.1 | 1.7 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.0 | 1.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 0.3 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.0 | 1.3 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 8.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 4.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.2 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 1.3 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.2 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.0 | 1.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.9 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.7 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.0 | 1.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.8 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.0 | 3.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.2 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.0 | 0.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.6 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 13.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.1 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.0 | 1.0 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.0 | GO:0043682 | copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682) |
| 0.0 | 4.0 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 1.3 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.2 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 0.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 2.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 1.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 4.8 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 1.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.8 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.4 | 5.5 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.3 | 5.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 12.4 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 4.5 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.1 | 2.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 1.6 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 13.6 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 1.5 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 1.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 1.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 1.4 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 2.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 7.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.5 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.0 | 0.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.7 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 1.1 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.8 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 0.3 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.6 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |