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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for OTX1

Z-value: 4.46

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Transcription factors associated with OTX1

Gene Symbol Gene ID Gene Info
OTX1
ENSG00000115507.10 OTX1

Activity profile of OTX1 motif

Sorted Z-values of OTX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_92075441 19.51 ENST00000596516.2
SETSIP
SET like protein
chr19_-_47113756 13.28 ENST00000253048.10
ZC3H4
zinc finger CCCH-type containing 4
chr16_-_58129358 13.04 ENST00000565880.1
ENST00000262498.8
CFAP20
cilia and flagella associated protein 20
chr12_-_53677397 12.77 ENST00000338662.6
ENST00000552242.5
ATP5MC2
ATP synthase membrane subunit c locus 2
chr1_+_224356852 12.04 ENST00000366858.7
ENST00000366857.9
ENST00000465271.6
ENST00000366856.3
CNIH4
cornichon family AMPA receptor auxiliary protein 4
chr2_-_85410336 11.35 ENST00000263867.9
ENST00000409921.5
CAPG
capping actin protein, gelsolin like
chr19_-_10420121 11.20 ENST00000593124.1
CDC37
cell division cycle 37, HSP90 cochaperone
chr16_+_33802683 11.12 ENST00000570121.2
IGHV3OR16-12
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr13_+_97960192 10.24 ENST00000496368.6
ENST00000421861.7
ENST00000357602.7
IPO5
importin 5
chr3_+_142596385 9.98 ENST00000457734.7
ENST00000483373.5
ENST00000475296.5
ENST00000495744.5
ENST00000476044.5
ENST00000461644.5
ENST00000464320.5
PLS1
plastin 1
chr2_+_201071984 9.66 ENST00000237889.9
ENST00000433898.5
ENST00000684175.1
ENST00000682325.1
ENST00000454214.1
ENST00000684420.1
NDUFB3
NADH:ubiquinone oxidoreductase subunit B3
chr11_-_67508152 8.62 ENST00000301488.8
CDK2AP2
cyclin dependent kinase 2 associated protein 2
chr2_-_175181663 8.60 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP5MC3
ATP synthase membrane subunit c locus 3
chr2_-_105438503 8.32 ENST00000393352.7
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr3_+_138621225 7.98 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr2_+_109898685 7.97 ENST00000480744.2
LIMS3
LIM zinc finger domain containing 3
chr1_+_146949314 7.85 ENST00000617844.4
ENST00000611443.4
NBPF12
NBPF member 12
chr3_-_142029108 7.24 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr3_+_138621207 7.20 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr20_-_34951852 7.01 ENST00000451957.2
GSS
glutathione synthetase
chr16_-_69339493 6.96 ENST00000562595.5
ENST00000615447.1
ENST00000306875.10
ENST00000562081.2
COG8
component of oligomeric golgi complex 8
chrX_+_101390824 6.75 ENST00000427805.6
ENST00000614077.4
RPL36A
ribosomal protein L36a
chr1_-_205750167 6.61 ENST00000367142.5
NUCKS1
nuclear casein kinase and cyclin dependent kinase substrate 1
chr3_-_130746760 6.57 ENST00000356763.8
PIK3R4
phosphoinositide-3-kinase regulatory subunit 4
chr6_-_144095556 6.42 ENST00000367569.4
SF3B5
splicing factor 3b subunit 5
chr22_+_29767351 6.38 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chrX_-_135022473 6.34 ENST00000391440.3
RTL8B
retrotransposon Gag like 8B
chr2_+_121755545 6.31 ENST00000536142.5
ENST00000389682.8
TSN
translin
chr4_-_121823843 6.24 ENST00000274026.10
CCNA2
cyclin A2
chr3_-_69080350 6.08 ENST00000630585.1
ENST00000361055.9
ENST00000415609.6
ENST00000349511.8
UBA3
ubiquitin like modifier activating enzyme 3
chr4_+_74308463 6.04 ENST00000413830.6
EPGN
epithelial mitogen
chr5_+_136160986 5.90 ENST00000507637.1
SMAD5
SMAD family member 5
chr2_-_74392025 5.80 ENST00000440727.1
ENST00000409240.5
DCTN1
dynactin subunit 1
chr19_+_34428353 5.76 ENST00000590048.6
ENST00000246548.9
UBA2
ubiquitin like modifier activating enzyme 2
chr17_+_58692563 5.72 ENST00000461271.5
ENST00000583539.5
ENST00000337432.9
ENST00000421782.3
RAD51C
RAD51 paralog C
chr12_+_20810698 5.68 ENST00000540853.5
ENST00000381545.8
SLCO1B3
solute carrier organic anion transporter family member 1B3
chr11_-_67508091 5.67 ENST00000531506.1
CDK2AP2
cyclin dependent kinase 2 associated protein 2
chr8_-_144426982 5.59 ENST00000526054.5
ENST00000529182.5
VPS28
VPS28 subunit of ESCRT-I
chr3_-_149377637 5.46 ENST00000305366.8
TM4SF1
transmembrane 4 L six family member 1
chr17_+_43006740 5.44 ENST00000438323.2
ENST00000415816.7
IFI35
interferon induced protein 35
chr12_-_14803462 5.33 ENST00000261167.7
ENST00000535328.1
WBP11
WW domain binding protein 11
chr21_-_32603237 4.99 ENST00000431599.1
CFAP298
cilia and flagella associated protein 298
chr20_-_34112205 4.97 ENST00000374980.3
EIF2S2
eukaryotic translation initiation factor 2 subunit beta
chr10_+_58385395 4.95 ENST00000487519.6
ENST00000373895.7
TFAM
transcription factor A, mitochondrial
chr6_-_34426020 4.87 ENST00000621356.3
ENST00000494077.6
ENST00000639877.1
RPS10
RPS10-NUDT3
ribosomal protein S10
RPS10-NUDT3 readthrough
chr1_-_88992924 4.78 ENST00000370486.1
ENST00000399794.6
KYAT3
RBMXL1
kynurenine aminotransferase 3
RBMX like 1
chr14_+_20989968 4.71 ENST00000382985.8
ENST00000339374.11
ENST00000556670.6
ENST00000553564.5
ENST00000554751.5
ENST00000554283.1
ENST00000555670.1
METTL17
methyltransferase like 17
chr18_+_8717371 4.67 ENST00000359865.7
MTCL1
microtubule crosslinking factor 1
chr14_-_106005574 4.65 ENST00000390595.3
IGHV1-3
immunoglobulin heavy variable 1-3
chr10_-_46023445 4.61 ENST00000585132.5
NCOA4
nuclear receptor coactivator 4
chr16_-_29863117 4.54 ENST00000566113.5
ENST00000569956.5
ENST00000570016.5
ENST00000219789.11
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr3_+_136930469 4.50 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr8_+_108443601 4.44 ENST00000524143.5
ENST00000220853.8
EMC2
ER membrane protein complex subunit 2
chr1_+_174875505 4.43 ENST00000486220.5
RABGAP1L
RAB GTPase activating protein 1 like
chr1_-_54887161 4.38 ENST00000535035.6
ENST00000371269.9
ENST00000436604.2
DHCR24
24-dehydrocholesterol reductase
chr14_-_106675544 4.29 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr5_-_111756245 4.29 ENST00000447165.6
NREP
neuronal regeneration related protein
chr4_+_83035159 4.28 ENST00000509317.5
ENST00000264389.7
ENST00000503682.5
ENST00000511653.1
COPS4
COP9 signalosome subunit 4
chr12_+_6494087 4.19 ENST00000382457.8
ENST00000315579.10
NCAPD2
non-SMC condensin I complex subunit D2
chr6_-_34426052 4.08 ENST00000344700.8
ENST00000644700.1
ENST00000648437.1
ENST00000644393.1
ENST00000639725.1
RPS10
RPS10-NUDT3
ribosomal protein S10
RPS10-NUDT3 readthrough
chr17_-_38825303 4.06 ENST00000614790.5
CWC25
CWC25 spliceosome associated protein homolog
chr1_-_9751540 3.97 ENST00000435891.5
CLSTN1
calsyntenin 1
chr8_+_131904071 3.92 ENST00000254624.10
ENST00000522709.5
EFR3A
EFR3 homolog A
chr3_-_11643871 3.88 ENST00000430365.7
VGLL4
vestigial like family member 4
chr2_+_222860942 3.83 ENST00000392066.7
ENST00000680251.1
ENST00000679541.1
ENST00000679545.1
ENST00000680395.1
ACSL3
acyl-CoA synthetase long chain family member 3
chr11_-_65859282 3.79 ENST00000526975.1
ENST00000531413.5
ENST00000525451.6
CFL1
cofilin 1
chr1_+_74235377 3.79 ENST00000326637.8
TNNI3K
TNNI3 interacting kinase
chr20_+_54208072 3.74 ENST00000371419.7
PFDN4
prefoldin subunit 4
chr2_-_24084822 3.53 ENST00000238721.9
TP53I3
tumor protein p53 inducible protein 3
chr1_+_109213887 3.49 ENST00000234677.7
ENST00000369923.4
SARS1
seryl-tRNA synthetase 1
chr1_-_165698863 3.45 ENST00000354775.4
ALDH9A1
aldehyde dehydrogenase 9 family member A1
chr1_+_81306096 3.35 ENST00000370721.5
ENST00000370727.5
ENST00000370725.5
ENST00000370723.5
ENST00000370728.5
ENST00000370730.5
ADGRL2
adhesion G protein-coupled receptor L2
chr1_-_16156059 3.31 ENST00000358432.8
EPHA2
EPH receptor A2
chr1_+_150321523 3.21 ENST00000324862.7
PRPF3
pre-mRNA processing factor 3
chr11_-_112086727 3.17 ENST00000504148.3
ENST00000541231.1
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B
chr1_+_172533104 3.07 ENST00000616058.4
ENST00000263688.4
ENST00000610051.5
SUCO
SUN domain containing ossification factor
chr2_+_222861005 2.95 ENST00000680147.1
ENST00000681009.1
ENST00000679514.1
ENST00000357430.8
ACSL3
acyl-CoA synthetase long chain family member 3
chr9_+_122370523 2.89 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr1_+_28438104 2.84 ENST00000633167.1
ENST00000373836.4
PHACTR4
phosphatase and actin regulator 4
chr12_+_100200779 2.80 ENST00000188312.7
ENST00000546902.5
ENST00000552376.5
ENST00000551617.1
ACTR6
actin related protein 6
chr16_-_29862890 2.79 ENST00000563415.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr19_+_13151975 2.75 ENST00000588173.1
IER2
immediate early response 2
chr12_-_32755876 2.73 ENST00000324868.13
YARS2
tyrosyl-tRNA synthetase 2
chr5_-_82278396 2.66 ENST00000510019.5
RPS23
ribosomal protein S23
chr16_+_68085552 2.65 ENST00000329524.8
NFATC3
nuclear factor of activated T cells 3
chr15_+_42495253 2.62 ENST00000349777.5
SNAP23
synaptosome associated protein 23
chr16_-_21857657 2.31 ENST00000341400.11
ENST00000518761.8
ENST00000682606.1
NPIPB4
nuclear pore complex interacting protein family member B4
chr16_-_29404029 2.28 ENST00000524087.5
NPIPB11
nuclear pore complex interacting protein family member B11
chr2_-_47176453 2.28 ENST00000484408.5
ENST00000489742.1
ENST00000272298.12
ENST00000656538.1
ENST00000409563.5
ENST00000456319.6
ENST00000628793.2
CALM2
calmodulin 2
chr7_-_101252133 2.20 ENST00000435848.1
ENST00000474120.5
FIS1
fission, mitochondrial 1
chr11_-_6799689 2.15 ENST00000641196.1
OR6A2
olfactory receptor family 6 subfamily A member 2
chr1_-_216423396 2.12 ENST00000366942.3
ENST00000674083.1
ENST00000307340.8
USH2A
usherin
chr12_-_89656051 2.07 ENST00000261173.6
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr18_+_23689439 2.01 ENST00000313654.14
LAMA3
laminin subunit alpha 3
chr14_-_24442241 2.01 ENST00000555355.5
ENST00000553343.5
ENST00000556523.1
ENST00000556249.1
ENST00000538105.6
ENST00000555225.5
SDR39U1
short chain dehydrogenase/reductase family 39U member 1
chr16_-_21425278 2.00 ENST00000504841.6
ENST00000419180.6
NPIPB3
nuclear pore complex interacting protein family member B3
chr16_+_14708944 1.99 ENST00000526520.5
ENST00000531598.6
NPIPA3
nuclear pore complex interacting protein family member A3
chr15_-_19988117 1.90 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr11_-_67443459 1.85 ENST00000341356.10
ENST00000627576.2
CORO1B
coronin 1B
chr13_-_31162341 1.82 ENST00000445273.6
ENST00000630972.2
HSPH1
heat shock protein family H (Hsp110) member 1
chr6_+_4889992 1.79 ENST00000343762.5
CDYL
chromodomain Y like
chr4_-_82848843 1.76 ENST00000511338.1
SEC31A
SEC31 homolog A, COPII coat complex component
chr5_-_82278341 1.76 ENST00000510210.5
ENST00000512493.5
ENST00000296674.13
ENST00000507980.1
ENST00000511844.1
ENST00000651545.1
RPS23
ribosomal protein S23
chr10_-_34815257 1.70 ENST00000374789.8
ENST00000374788.8
ENST00000346874.9
ENST00000374794.8
ENST00000350537.9
ENST00000374790.8
ENST00000374776.6
ENST00000374773.6
ENST00000545260.5
ENST00000545693.5
ENST00000340077.9
PARD3
par-3 family cell polarity regulator
chr14_-_106803221 1.59 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chr7_+_120988683 1.54 ENST00000340646.9
ENST00000310396.10
CPED1
cadherin like and PC-esterase domain containing 1
chr7_+_128739395 1.44 ENST00000479257.5
CALU
calumenin
chr6_-_69699124 1.36 ENST00000651675.1
LMBRD1
LMBR1 domain containing 1
chr6_+_26251607 1.31 ENST00000619466.2
H2BC9
H2B clustered histone 9
chr17_-_28549333 1.28 ENST00000470125.5
UNC119
unc-119 lipid binding chaperone
chr2_+_71331728 1.28 ENST00000437658.2
ENST00000464375.5
ENST00000475743.1
ENST00000409544.5
ENST00000455226.5
ENST00000454278.5
ENST00000417778.5
ENST00000454122.1
ENST00000264447.9
ZNF638
zinc finger protein 638
chr11_+_8683201 1.23 ENST00000526562.5
ENST00000525981.1
RPL27A
ribosomal protein L27a
chr17_+_59940908 1.15 ENST00000591035.1
ENSG00000267318.1
novel protein
chr17_-_19745602 1.08 ENST00000444455.5
ENST00000439102.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr8_-_33513077 1.00 ENST00000360742.9
ENST00000523305.1
ENST00000431156.7
ENST00000613904.1
TTI2
TELO2 interacting protein 2
chr6_+_95577465 0.95 ENST00000369293.6
ENST00000683151.1
ENST00000358812.9
MANEA
mannosidase endo-alpha
chr6_-_32763466 0.93 ENST00000427449.1
ENST00000411527.5
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr22_+_38656627 0.91 ENST00000411557.5
ENST00000396811.6
ENST00000216029.7
ENST00000416285.5
CBY1
chibby family member 1, beta catenin antagonist
chr15_-_61229297 0.82 ENST00000335670.11
RORA
RAR related orphan receptor A
chr15_+_84980440 0.73 ENST00000310298.8
ENST00000557957.5
PDE8A
phosphodiesterase 8A
chr16_-_31064952 0.73 ENST00000426488.6
ZNF668
zinc finger protein 668
chr19_-_42412347 0.73 ENST00000601189.1
ENST00000599211.1
LIPE
lipase E, hormone sensitive type
chr19_+_35449584 0.71 ENST00000246549.2
FFAR2
free fatty acid receptor 2
chr1_-_186461089 0.58 ENST00000391997.3
PDC
phosducin
chr19_-_3761657 0.54 ENST00000316757.4
APBA3
amyloid beta precursor protein binding family A member 3
chr2_-_111884117 0.48 ENST00000341068.8
ANAPC1
anaphase promoting complex subunit 1
chr3_-_69013639 0.40 ENST00000456376.2
ENST00000383701.8
EOGT
EGF domain specific O-linked N-acetylglucosamine transferase
chr9_-_92482499 0.39 ENST00000375544.7
ASPN
asporin
chr7_-_100641507 0.32 ENST00000431692.5
ENST00000223051.8
TFR2
transferrin receptor 2
chr9_+_21802628 0.32 ENST00000644715.2
ENST00000460874.6
ENST00000580900.5
MTAP
methylthioadenosine phosphorylase
chr8_-_78805515 0.30 ENST00000379113.6
ENST00000541183.2
IL7
interleukin 7
chr1_-_151327684 0.27 ENST00000368874.8
PI4KB
phosphatidylinositol 4-kinase beta
chr13_+_38349822 0.25 ENST00000379649.5
ENST00000239878.9
UFM1
ubiquitin fold modifier 1
chr16_-_31065011 0.23 ENST00000539836.3
ENST00000535577.5
ENST00000442862.2
ZNF668
zinc finger protein 668
chr14_-_106511856 0.22 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr9_-_92482350 0.21 ENST00000375543.2
ASPN
asporin
chr10_+_112374110 0.11 ENST00000354655.9
ACSL5
acyl-CoA synthetase long chain family member 5
chr15_-_68229658 0.10 ENST00000565471.6
ENST00000637494.1
ENST00000636314.1
ENST00000637667.1
ENST00000564752.1
ENST00000566347.5
ENST00000249806.11
ENST00000562767.2
CLN6
ENSG00000260007.3
CLN6 transmembrane ER protein
novel protein
chr19_-_53159004 0.01 ENST00000599096.1
ENST00000597183.5
ENST00000601804.5
ENST00000334197.12
ENST00000601469.2
ENST00000452676.6
ZNF347
zinc finger protein 347

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.3 GO:2000035 regulation of stem cell division(GO:2000035)
2.6 13.0 GO:1902019 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
2.2 6.6 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
2.1 8.3 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
2.1 6.2 GO:0071314 cellular response to cocaine(GO:0071314) cellular response to luteinizing hormone stimulus(GO:0071373)
2.0 10.0 GO:1902896 terminal web assembly(GO:1902896)
1.9 5.6 GO:0070086 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
1.7 6.8 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
1.7 5.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
1.5 6.1 GO:0007113 endomitotic cell cycle(GO:0007113)
1.5 4.5 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
1.3 6.6 GO:0030242 pexophagy(GO:0030242)
1.1 3.3 GO:1901491 axial mesoderm morphogenesis(GO:0048319) negative regulation of lymphangiogenesis(GO:1901491)
1.0 5.9 GO:0001880 Mullerian duct regression(GO:0001880)
1.0 5.7 GO:0051177 meiotic DNA recombinase assembly(GO:0000707) meiotic sister chromatid cohesion(GO:0051177)
0.9 2.8 GO:0061386 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.8 5.0 GO:0002176 male germ cell proliferation(GO:0002176) germ cell proliferation(GO:0036093)
0.8 4.8 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.8 3.8 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.7 4.4 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.7 5.8 GO:0090063 microtubule anchoring at centrosome(GO:0034454) positive regulation of microtubule nucleation(GO:0090063)
0.7 6.4 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.7 4.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.7 10.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.6 11.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.5 2.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.5 4.7 GO:2000576 positive regulation of microtubule motor activity(GO:2000576)
0.5 11.2 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
0.5 1.8 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.5 7.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.4 2.2 GO:1904579 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.4 6.3 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.4 2.7 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.4 9.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 0.7 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.3 2.1 GO:1990034 calcium ion export from cell(GO:1990034)
0.3 3.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 6.0 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.3 7.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 1.3 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.3 23.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 1.8 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.3 4.3 GO:0000338 protein deneddylation(GO:0000338)
0.3 5.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 3.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.2 4.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 1.4 GO:0038016 insulin receptor internalization(GO:0038016)
0.2 2.6 GO:0002441 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.2 3.8 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.2 19.5 GO:0006334 nucleosome assembly(GO:0006334)
0.2 7.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 5.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 3.2 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.1 4.4 GO:0018126 protein hydroxylation(GO:0018126)
0.1 9.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.6 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 2.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 3.6 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 7.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.7 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 2.6 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 1.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.6 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.3 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.1 1.7 GO:0008356 asymmetric cell division(GO:0008356)
0.1 2.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 3.5 GO:0006739 NADP metabolic process(GO:0006739)
0.1 12.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.8 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 1.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.3 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 4.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 5.8 GO:0016925 protein sumoylation(GO:0016925)
0.0 5.4 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 4.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.2 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.7 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 1.1 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 2.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.7 GO:0006457 protein folding(GO:0006457)
0.0 0.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
1.7 10.0 GO:1990357 terminal web(GO:1990357)
1.4 5.8 GO:0031510 SUMO activating enzyme complex(GO:0031510)
1.4 4.2 GO:0000799 nuclear condensin complex(GO:0000799)
1.2 5.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.0 6.2 GO:0001940 male pronucleus(GO:0001940)
1.0 5.7 GO:0033061 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.9 11.4 GO:0008290 F-actin capping protein complex(GO:0008290)
0.6 5.6 GO:0000813 ESCRT I complex(GO:0000813)
0.5 7.0 GO:0017119 Golgi transport complex(GO:0017119)
0.5 3.7 GO:0016272 prefoldin complex(GO:0016272)
0.5 2.1 GO:1990075 stereocilia coupling link(GO:0002139) periciliary membrane compartment(GO:1990075)
0.5 4.6 GO:0044754 autolysosome(GO:0044754)
0.5 4.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.5 6.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.4 23.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.4 5.8 GO:0005869 dynactin complex(GO:0005869)
0.4 4.7 GO:0097427 microtubule bundle(GO:0097427)
0.4 3.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 6.4 GO:0005686 U2 snRNP(GO:0005686)
0.3 2.0 GO:0005610 laminin-5 complex(GO:0005610)
0.3 1.7 GO:0033269 internode region of axon(GO:0033269)
0.3 5.9 GO:0071141 SMAD protein complex(GO:0071141)
0.3 4.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 27.0 GO:0005811 lipid particle(GO:0005811)
0.1 9.6 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 7.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.4 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 8.3 GO:0031430 M band(GO:0031430)
0.1 3.2 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 9.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 12.5 GO:0005814 centriole(GO:0005814)
0.1 2.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 10.2 GO:0005643 nuclear pore(GO:0005643)
0.1 4.3 GO:0008180 COP9 signalosome(GO:0008180)
0.1 2.6 GO:0042629 mast cell granule(GO:0042629)
0.1 12.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 2.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 8.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.3 GO:0051233 spindle midzone(GO:0051233)
0.0 4.7 GO:0005840 ribosome(GO:0005840)
0.0 2.3 GO:0000922 spindle pole(GO:0000922)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 11.0 GO:0005874 microtubule(GO:0005874)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 4.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 6.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 3.2 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 4.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 4.4 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0047315 kynurenine-glyoxylate transaminase activity(GO:0047315)
1.3 12.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.2 5.0 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.9 11.8 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.8 3.4 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.8 5.7 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.8 7.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.8 6.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.8 4.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.6 3.5 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.6 2.9 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.5 4.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.4 7.0 GO:0043295 glutathione binding(GO:0043295)
0.4 5.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.4 10.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.4 23.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.4 3.8 GO:0031013 troponin I binding(GO:0031013)
0.3 5.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 4.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 6.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.3 1.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.3 2.8 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 0.7 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 11.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 9.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 12.9 GO:0050681 androgen receptor binding(GO:0050681)
0.2 1.4 GO:0015235 cobalamin transporter activity(GO:0015235)
0.1 5.8 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.8 GO:0008142 oxysterol binding(GO:0008142)
0.1 4.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 3.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 2.7 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 5.3 GO:0050699 WW domain binding(GO:0050699)
0.1 0.3 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 6.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.6 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 6.2 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.1 23.0 GO:0051015 actin filament binding(GO:0051015)
0.1 12.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 17.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.0 GO:0019894 kinesin binding(GO:0019894)
0.1 5.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.9 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 2.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 5.6 GO:0043130 ubiquitin binding(GO:0043130)
0.0 3.7 GO:0051087 chaperone binding(GO:0051087)
0.0 2.3 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 19.7 GO:0003682 chromatin binding(GO:0003682)
0.0 0.3 GO:0004645 phosphorylase activity(GO:0004645)
0.0 1.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 2.1 GO:0017022 myosin binding(GO:0017022)
0.0 2.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 3.0 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.0 GO:0008168 methyltransferase activity(GO:0008168)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.9 PID ALK2 PATHWAY ALK2 signaling events
0.2 6.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 8.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 10.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 11.2 PID LKB1 PATHWAY LKB1 signaling events
0.1 7.8 PID ARF6 PATHWAY Arf6 signaling events
0.1 15.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 5.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 4.2 PID AURORA B PATHWAY Aurora B signaling
0.1 5.6 PID E2F PATHWAY E2F transcription factor network
0.1 3.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.7 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 3.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.6 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.4 6.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.4 11.2 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.4 5.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 8.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 6.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 6.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 6.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 7.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 6.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 14.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 2.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.2 5.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 18.2 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 3.8 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 5.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 9.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 4.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.7 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 5.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 7.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 5.0 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.1 1.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 8.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 3.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 5.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.6 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 7.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane